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https://www.readbyqxmd.com/read/29764780/what-is-the-required-frequency-of-mri-scanning-in-the-wait-and-scan-management
#1
Thomas Somers, Romain Kania, Jerome Waterval, Tony Van Havenbergh
The wait and scan policy is being increasingly used as the first measure after the diagnosis of a vestibular schwannoma (VS) using magnetic resonance imaging (MRI). As part of the European Academy of Otology and Neuro-Otology (EAONO) position statement on VS, the frequency of imaging has been studied in the literature. Among 163 studies, 29 fulfilled the inclusion criteria and were scored using the Grading of Recommendations, Assessment, Development, and Evaluation system. Because tumor growth rate during the first 5 years of follow-up is predictive of further growth during the upcoming years, a protocol for wait and scan is useful for centers dealing with this condition...
April 2018: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29756589/effect-of-combination-therapy-with-neuroprotective-and-vasoprotective-agents-on-cerebral-ischemia
#2
Jiping Yang, Bei Yang, Baoxin Xiu, Jinchong Qi, Huaijun Liu
Because most tested drugs are active against only one of the damaging processes associated with stroke, other mechanisms may cause cellular death. Thus, a combination of protective agents targeting different pathophysiological mechanisms may obtain better effects than a single agent. The major objective of this study was to investigate the effect of combination therapy with vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) after controlled ischemic brain injury in rabbits. METHODS: Animals were randomly assigned to one of the following groups: sham group, saline-treated control group or NGF+VEGF-treated group...
May 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29741791/the-trophic-effect-of-nerve-growth-factor-in-primary-cultures-of-rat-hippocampal-neurons-is-associated-to-an-anti-inflammatory-and-immunosuppressive-transcriptional-program
#3
Barbara Maino, Antonio G Spampinato, Cinzia Severini, Carla Petrella, Maria Teresa Ciotti, Velia D'Agata, Pietro Calissano, Sebastiano Cavallaro
Nerve growth factor, the prototype of a family of neurotrophins, elicits differentiation and survival of peripheral and central neuronal cells. Although its neural mechanisms have been studied extensively, relatively little is known about the transcriptional regulation governing its effects. We have previously observed that in primary cultures of rat hippocampal neurons treatment with nerve growth factor for 72 hr increases neurite outgrowth and cell survival. To obtain a comprehensive view of the underlying transcriptional program, we performed whole-genome expression analysis by microarray technology...
May 9, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29734623/prognoses-of-diameter-and-height-of-trees-of-eucalyptus-using-artificial-intelligence
#4
Giovanni Correia Vieira, Adriano Ribeiro de Mendonça, Gilson Fernandes da Silva, Sidney Sára Zanetti, Mayra Marques da Silva, Alexandre Rosa Dos Santos
Models of individual trees are composed of sub-models that generally estimate competition, mortality, and growth in height and diameter of each tree. They are usually adopted when we want more detailed information to estimate forest multiproduct. In these models, estimates of growth in diameter at 1.30m above the ground (DBH) and total height (H) are obtained by regression analysis. Recently, artificial intelligence techniques (AIT) have been used with satisfactory performance in forest measurement. Therefore, the objective of this study was to evaluate the performance of two AIT, artificial neural networks and adaptive neuro-fuzzy inference system, to estimate the growth in DBH and H of eucalyptus trees...
April 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29709615/common-proteomic-profiles-of-induced-pluripotent-stem-cell-derived-three-dimensional-neurons-and-brain-tissue-from-alzheimer-patients
#5
Mei Chen, Han-Kyu Lee, Lauren Moo, Eugene Hanlon, Thor Stein, Weiming Xia
We established a unique platform for proteomic analysis of cultured three-dimensional (3D) neurons and brain tissue from Alzheimer's disease (AD) patients. We collected peripheral blood mononuclear cells (PBMC), converted PBMC to induced pluripotent stem cell (iPSC) lines, and differentiated the iPSC into human 3D neuro-spheroids. The postmortem brain tissue from the superior frontal cortex, inferior frontal cortex and cerebellum area of the AD patients was compared to the same regions from the control subjects...
April 27, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29708785/interval-change-in-diffusion-and-perfusion-mri-parameters-for-the-assessment-of-pseudoprogression-in-cerebral-metastases-treated-with-stereotactic-radiation
#6
James R Knitter, William K Erly, Baldassarre D Stea, Gerald M Lemole, Isabelle M Germano, Amish H Doshi, Kambiz Nael
OBJECTIVE: Apparent increases in the size of cerebral metastases after stereotactic radiosurgery (SRS) can be caused by pseudoprogression or true disease progression, which poses a diagnostic challenge at conventional MRI. The purpose of this study was to assess whether interval change in DWI and perfusion MRI parameters can differentiate pseudoprogression from progressive disease after treatment with SRS. MATERIALS AND METHODS: Patients with apparent growth of cerebral metastases after SRS treatment who underwent pre- and post-SRS DWI, dynamic susceptibility contrast (DSC)-MRI, and perfusion dynamic contrast-enhanced (DCE)-MRI were retrospectively evaluated...
April 30, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29698439/tnf-differentially-regulates-ganglioside-biosynthesis-and-expression-in-breast-cancer-cell-lines
#7
Justine H Dewald, Sumeyye Cavdarli, Agata Steenackers, Clément P Delannoy, Marlène Mortuaire, Corentin Spriet, Maxence Noël, Sophie Groux-Degroote, Philippe Delannoy
Gangliosides are glycosphingolipids concentrated in glycolipid-enriched membrane microdomains. Mainly restricted to the nervous system in healthy adult, complex gangliosides such as GD3 and GD2 have been shown to be involved in aggressiveness and metastasis of neuro-ectoderm derived tumors such as melanoma and neuroblastoma. GD3 synthase (GD3S), the key enzyme that controls the biosynthesis of complex gangliosides, was shown to be over-expressed in Estrogen Receptor (ER)-negative breast cancer tumors, and associated with a decreased overall survival of patients...
2018: PloS One
https://www.readbyqxmd.com/read/29692920/brain-tumor-biobanking-in-the-precision-medicine-era-building-a-high-quality-resource-for-translational-research-in-neuro-oncology
#8
REVIEW
Quinn T Ostrom, Karen Devine, Jordonna Fulop, Yingli Wolinsky, Peter Liao, Lindsay Stetson, Marta Couce, Andrew E Sloan, Jill S Barnholtz-Sloan
The growth of precision medicine has made access to biobanks with high-quality, well-annotated neuro-oncology biospecimens critical. Developing and maintaining neuro-oncology biobanks is best accomplished through multidisciplinary collaboration between clinicians and researchers. Balancing the needs and leveraging the skills of all stakeholders in this multidisciplinary effort is of utmost importance. Collaboration with a multidisciplinary team of clinicians, health care team members, and institutions, as well as patients and their families, is essential for access to participants in order to obtain informed consent, collect samples under strict standard operating procedures, and accurate and relevant clinical annotation...
December 2017: Neuro-oncology Practice
https://www.readbyqxmd.com/read/29684179/comparing-plant-and-animal-glutamate-receptors-common-traits-but-different-fates
#9
Michael M Wudick, Erwan Michard, Custódio Oliveira Nunes, José A Feijó
Animal ionotropic glutamate receptors (iGluRs) are ligand-gated channels whose evolution is intimately linked to the one of the nervous system, where the agonist glutamate and co-agonists glycine/D-serine act as neuro-transmitters or -modulators. While iGluRs are specialized in neuronal communication, plant glutamate receptor-like (GLR) homologues have evolved many plant-specific physiological functions, such as sperm signaling in moss, pollen tube growth, root meristem proliferation, innate immune and wound responses...
April 19, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29680669/exposing-mesenchymal-stem-cells-to-chondroitin-sulphated-proteoglycans-reduces-their-angiogenic-and-neuro-adhesive-paracrine-activity
#10
Chelsea R Wood, Ibtesam R T Al Delfi, John F Innes, Peter Myint, William E B Johnson
The multifactorial complexity of spinal cord injuries includes the formation of a glial scar, of which chondroitin sulphated proteoglycans (CSPG) are an integral component. Previous studies have shown CSPG to have inhibitory effects on endothelial and neuronal cell growth, highlighting the difficulty of spinal cord regeneration. Mesenchymal stem/stromal cells (MSC) are widely used a cell therapy, and there is mounting evidence for their angiogenic and neurotrophic paracrine properties. However, in vivo studies have observed poor engraftment and survival of MSC when injected into SCI...
April 19, 2018: Biochimie
https://www.readbyqxmd.com/read/29666296/phase-ii-study-to-evaluate-the-efficacy-and-safety-of-rilotumumab-and-bevacizumab-in-subjects-with-recurrent-malignant-glioma
#11
Mary Lou Affronti, Jennifer Gamboa Jackman, Frances McSherry, James E Herndon, Elwood C Massey, Eric Lipp, Annick Desjardins, Henry S Friedman, Gordana Vlahovic, James Vredenburgh, Katherine B Peters
LESSONS LEARNED: Due to evolving imaging criteria in brain tumors and variation in magnetic resonance imaging evaluation, it is not ideal to use response rate as a primary objective. Future studies involving antiangiogenic agents should use overall survival.Disease-expected toxicities should be considered when defining the clinical significance of an adverse event. For example, vascular thromboembolic events are common in brain tumor patients and should not be attributed to the study drug in the safety analysis...
April 17, 2018: Oncologist
https://www.readbyqxmd.com/read/29664942/dietary-cyanogen-exposure-and-early-child-neurodevelopment-an-observational-study-from-the-democratic-republic-of-congo
#12
Espérance Kashala-Abotnes, Marie-Thérèse Sombo, Daniel L Okitundu, Marcel Kunyu, Guy Bumoko Makila-Mabe, Thorkild Tylleskär, Alla Sikorskii, Jean-Pierre Banea, Dieudonné Mumba Ngoyi, Désiré Tshala-Katumbay, Michael J Boivin
BACKGROUND: Dietary cyanogen exposure from ingesting bitter (toxic) cassava as a main source of food in sub-Saharan Africa is related to neurological impairments in sub-Saharan Africa. We explored possible association with early child neurodevelopmental outcomes. METHODS: We undertook a cross-sectional neurodevelopmental assessment of 12-48 month-old children using the Mullen Scale of Early Learning (MSEL) and the Gensini Gavito Scale (GGS). We used the Hopkins Symptoms Checklist-10 (HSCL-10) and Goldberg Depression Anxiety Scale (GDAS) to screen for symptoms of maternal depression-anxiety...
2018: PloS One
https://www.readbyqxmd.com/read/29661156/synergic-trial-synchronizing-exercises-remedies-in-gait-and-cognition-a-multi-centre-randomized-controlled-double-blind-trial-to-improve-gait-and-cognition-in-mild-cognitive-impairment
#13
Manuel Montero-Odasso, Quincy J Almeida, Amer M Burhan, Richard Camicioli, Julien Doyon, Sarah Fraser, Karen Li, Teresa Liu-Ambrose, Laura Middleton, Susan Muir-Hunter, William McIlroy, José A Morais, Frederico Pieruccini-Faria, Kevin Shoemaker, Mark Speechley, Akshya Vasudev, G Y Zou, Nicolas Berryman, Maxime Lussier, Leanne Vanderhaeghe, Louis Bherer
BACKGROUND: Physical exercise, cognitive training, and vitamin D are low cost interventions that have the potential to enhance cognitive function and mobility in older adults, especially in pre-dementia states such as Mild Cognitive Impairment (MCI). Aerobic and progressive resistance exercises have benefits to cognitive performance, though evidence is somewhat inconsistent. We postulate that combined aerobic exercise (AE) and progressive resistance training (RT) (combined exercise) will have a better effect on cognition than a balance and toning control (BAT) intervention in older adults with MCI...
April 16, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29651966/specific-cytostatic-and-cytotoxic-effect-of-dihydrochelerythrine-in-glioblastoma-cells-role-of-nf-kb-b-catenin-and-stat3-il-6-pathways
#14
Tereza Cristina Costa Silva, Noelio de Jesus Menezes-Filho, Giselle Pinto de Faria Lopes, Diego Madureira de Oliveira, Ezequiel Pereira, Bruno Penas Seara Pitanga, Eudes S Velozo, Songeli Menezes Freire, Jorge Clarencio de Souza Andrade, Helena Lobo Borges, Stevens Kastrup Rehen, Vivaldo Moura-Neto, Silvia Lima Costa
A glioblastoma is a primary CNS tumor that is more aggressive and lethal than other brain tumors. Its location, rapid proliferation, invasive growth, angiogenesis and immunosuppression are the main factors that limit its treatment, making it a major challenge to neuro-oncology. OBJECTIVE: This study investigated the in vitro effects of the alkaloid dihydrochelerythrine (DHC), which is extracted from Zanthoxylum stelligerum, on the viability, proliferation, cell death and b-catenin, NFkB, STAT3/pSTAT3 and interleukins roles...
April 12, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29616301/reconstructing-the-molecular-life-history-of-gliomas
#15
REVIEW
Floris P Barthel, Pieter Wesseling, Roel G W Verhaak
At the time of their clinical manifestation, the heterogeneous group of adult and pediatric gliomas carries a wide range of diverse somatic genomic alterations, ranging from somatic single-nucleotide variants to structural chromosomal rearrangements. Somatic abnormalities may have functional consequences, such as a decrease, increase or change in mRNA transcripts, and cells pay a penalty for maintaining them. These abnormalities, therefore, must provide cells with a competitive advantage to become engrained into the glioma genome...
April 3, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29580168/photocrosslinkable-gelatin-tropoelastin-hydrogel-adhesives-for-peripheral-nerve-repair
#16
Jonathan R Soucy, Ehsan Shirzaei Sani, Roberto Portillo Lara, David Diaz, Felipe Dias, Anthony S Weiss, Abigail N Koppes, Ryan Koppes, Nasim Annabi
Suturing peripheral nerve transections is the predominant therapeutic strategy for nerve repair. However, the use of sutures lead to scar tissue formation, hinder nerve regeneration, and prevent functional recovery. Fibrin-based adhesives have been widely used for nerve reconstruction, but their limited adhesive and mechanical strength, and inability to promote nerve regeneration hampers their utility as a stand-alone intervention. To overcome these challenges, we engineered composite hydrogels that are neuro-supportive and possess strong tissue adhesion...
March 27, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29568068/identification-of-p38-mapk-as-a-novel-therapeutic-target-for-friedreich-s-ataxia
#17
M Grazia Cotticelli, Shujuan Xia, Avinash Kaur, Daniel Lin, Yongping Wang, Eric Ruff, John W Tobias, Robert B Wilson
Friedreich ataxia (FRDA) is an autosomal recessive neuro- and cardio-degenerative disorder caused by decreased expression of frataxin, a protein that localizes to mitochondria and is critical for iron-sulfur-cluster (ISC) assembly. There are no proven effective treatments for FRDA. We previously screened a random shRNA library and identified a synthetic shRNA (gFA11) that reverses the growth defect of FRDA cells in culture. We now report that gFA11 decreases cytokine secretion in primary FRDA fibroblasts and reverts other changes associated with cell senescence...
March 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29565290/role-of-inflammation-in-diabetic-retinopathy
#18
REVIEW
Anne Rübsam, Sonia Parikh, Patrice E Fort
Diabetic retinopathy is a common complication of diabetes and remains the leading cause of blindness among the working-age population. For decades, diabetic retinopathy was considered only a microvascular complication, but the retinal microvasculature is intimately associated with and governed by neurons and glia, which are affected even prior to clinically detectable vascular lesions. While progress has been made to improve the vascular alterations, there is still no treatment to counteract the early neuro-glial perturbations in diabetic retinopathy...
March 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29562624/gaba-and-gaba-alanine-from-the-red-microalgae-rhodosorus-marinus-exhibit-a-significant-neuro-soothing-activity-through-inhibition-of-neuro-inflammation-mediators-and-positive-regulation-of-trpv1-related-skin-sensitization
#19
Amandine Scandolera, Jane Hubert, Anne Humeau, Carole Lambert, Audrey De Bizemont, Chris Winkel, Abdelmajid Kaouas, Jean-Hugues Renault, Jean-Marc Nuzillard, Romain Reynaud
The aim of the present study was to investigate the neuro-soothing activity of a water-soluble hydrolysate obtained from the red microalgae Rhodosorus marinus Geitler (Stylonemataceae). Transcriptomic analysis performed on ≈100 genes related to skin biological functions firstly revealed that the crude Rhodosorus marinus extract was able to significantly negatively modulate specific genes involved in pro-inflammation (interleukin 1α encoding gene, IL1A) and pain detection related to tissue inflammation (nerve growth factor NGF and its receptor NGFR)...
March 17, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29559832/a-new-look-at-etiological-factors-of-idiopathic-scoliosis-neural-crest-cells
#20
Alla M Zaydman, Elena L Strokova, Elena V Kiseleva, Lubov A Suldina, Anton A Strunov, Alexander I Shevchenko, Pavel P Laktionov, Vladimir M Subbotin
Idiopathic scoliosis is one of the most common disabling pathologies of children and adolescents. Etiology and pathogenesis of idiopathic scoliosis remain unknown. To study the etiology of this disease we identified the cells' phenotypes in the vertebral body growth plates in patients with idiopathic scoliosis. Materials and methods: The cells were isolated from vertebral body growth plates of the convex and concave sides of the deformity harvested intraoperatively in 50 patients with scoliosis. Cells were cultured and identified by methods of common morphology, neuromorphology, electron microscopy, immunohistochemistry and PCR analysis...
2018: International Journal of Medical Sciences
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