Jun Lei, Zihao Zhou, Jialing Fang, Zaiqiao Sun, Mengting He, Boxiao He, Qian Chen, Chonil Paek, Peng Chen, Jin Zhou, Hongjian Wang, Mingliang Tang, Lei Yin, Yongshun Chen
The use of aspirin is associated with reduced incidence of colorectal cancer (CRC). However, the detailed mechanism remains unclear. In this study, we reported that colon cancer cells treated with aspirin showed the hallmarks of immunogenic cell death (ICD), including surface expression of calreticulin (CRT) and heat shock protein 70 (HSP70). Mechanistically, aspirin induced endoplasmic reticulum (ER) stress in colon cancer cells. In addition, aspirin decreased the expression of the glucose transporters, GLUT3, and reduced the key enzyme of glycolysis, including HK2, PFKM, PKM2 and LDHA...
August 2023: International Immunopharmacology