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alginate hydrogel

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https://www.readbyqxmd.com/read/28315439/interaction-of-chitin-chitosan-with-salivary-and-other-epithelial-cells-an-overview
#1
REVIEW
Sharvari Vijaykumar Patil, Lalitha S Y Nanduri
Chitin and its deacetylated form, chitosan, have been widely used for tissue engineering of both epithelial and mesenchymal tissues. Epithelial cells characterised by their sheet-like tight cellular arrangement and polarised nature, constitute a major component in various organs and play a variety of roles including protection, secretion and maintenance of tissue homeostasis. Regeneration of damaged epithelial tissues has been studied using biomaterials such as chitin, chitosan, hyaluronan, gelatin and alginate...
March 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28315320/controlled-ice-nucleation-using-freeze-dried-pseudomonas-syringae-encapsulated-in-alginate-beads
#2
Lindong Weng, Shannon N Tessier, Anisa Swei, Shannon L Stott, Mehmet Toner
The control of ice nucleation is of fundamental significance in many process technologies related to food and pharmaceutical science and cryobiology. Mechanical perturbation, electromagnetic fields and ice-nucleating agents (INAs) have been known to induce ice nucleation in a controlled manner. But these ice-nucleating methods may suffer from cumbersome manual operations, safety concerns of external fields, and biocompatibility and recovery issues of INA particles, especially when used in living systems. Given the automatic ice-seeding nature of INAs, a promising solution to overcome some of the above limitations is to engineer a biocomposite that accommodates the INA particles but minimizes their interactions with biologics, as well as enabling the recovery of used particles...
March 14, 2017: Cryobiology
https://www.readbyqxmd.com/read/28306190/natural-polymeric-hydrogel-evaluation-for-skeletal-muscle-tissue-engineering
#3
Beth E Pollot, Christopher R Rathbone, Joseph C Wenke, Teja Guda
Although skeletal muscle has a remarkable ability to repair/regenerate after most types of injuries, there is limited regeneration after volumetric muscle loss (VML). A number of scaffold materials have been used in the development of grafts to treat VML, however, there is still a need to better understand the most appropriate material with regards to its ability to maintain mechanical integrity while also supporting myogenesis. Five commonly used natural polymeric materials (Collagen I, Agarose, Alginate, Fibrin, and Collagen Chitosan) used in skeletal muscle tissue engineering grafts were evaluated for their mechanical properties and myogenic capacity...
March 17, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28301717/glucose-triggered-insulin-release-from-fe3-cross-linked-alginate-hydrogel-experimental-study-and-theoretical-modeling
#4
Evgeny Katz, Sabrina Scheja, Sergii Domanskyi, Maria Gamella, Kelly L Wormwood, Costel C Darie, Arshak Poghossian, Michael J Schöning, Artem Melman, Vladimir Privman
We study the mechanisms involved in the release, triggered by the application of glucose, of insulin entrapped in Fe3+-cross-linked alginate hydrogel particles further stabilized with a polyelectrolyte. Platelet-shaped alginate particles are synthesized containing enzyme glucose oxidase conjugated with silica nanoparticles, which are also entrapped in the hydrogel. Glucose diffuses in from solution, and production of hydrogen peroxide is catalyzed by the enzyme within the hydrogel. We argue that, specifically for the Fe3+-cross-linked systems, the produced hydrogen peroxide is further converted to free radicals via a Fenton-type reaction catalyzed by the iron cations...
March 16, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28301613/simple-microfluidic-formation-of-highly-heterogeneous-microfibers-using-a-combination-of-sheath-units
#5
D H Yoon, K Kobayashi, D Tanaka, T Sekiguchi, S Shoji
This paper presents the formation of complex cross-sectional microfibers using three-dimensional microfluidic devices. The compartments and shapes of core and shell layers in the microfibers were independently controlled via three-dimensional fluidic channels fabricated by the combination of sheath units. The number of layers is easily expanded by the stacking of these units. Therefore, the highly heterogeneous microfibers of alginate hydrogel are obtained in polydimethylsiloxane structures. This widely expandable method has great potential for the development of functional and complex fiber-shaped materials...
March 16, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28295772/dual-physical-cross-linked-tough-and-photoluminescent-hydrogels-with-good-biocompatibility-and-antibacterial-activity
#6
Chen Hu, Mei Xiang Wang, Lei Sun, Jian Hai Yang, Miklós Zrínyi, Yong Mei Chen
Development of novel photoluminescent hydrogels with toughness, biocompatibility, and antibiosis is important for the applications in biomedical field. Herein, novel tough photoluminescent lanthanide (Ln)-alginate/poly(vinyl alcohol) (PVA) hydrogels with the properties of biocompatibility and antibiosis have been facilely synthesized by introducing hydrogen bonds and coordination bonds into the interpenetrating networks of Na-alginate and PVA, via approaches of frozen-thawing and ion-exchanging. The resultant hydrogels exhibit high mechanical strength (0...
March 15, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28288372/preparation-and-enhanced-mechanical-properties-of-hybrid-hydrogels-comprising-ultralong-hydroxyapatite-nanowires-and-sodium-alginate
#7
Ying-Ying Jiang, Ying-Jie Zhu, Heng Li, Yong-Gang Zhang, Yue-Qin Shen, Tuan-Wei Sun, Feng Chen
Hydrogels with 3-dimentional cross-linked structures are widely used in various biomedical fields such as bone repair scaffolds, drug carriers and biosensors. However, the applications of hydrogels are usually restricted because of their poor mechanical properties. Currently, nanocomposites, double network systems, hydrophobic association, macromolecules, and nanoparticles are commonly adopted as cross-linking agents to enhance mechanical properties of hydrogels. In this work, ultralong hydroxyapatite nanowires (HANWs) with lengths of several hundred microns are prepared and used to enhance the mechanical properties of sodium alginate (SA)-based hydrogels...
March 6, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28287033/marine-macromolecules-cross-linked-hydrogel-scaffolds-as-physiochemically-and-biologically-favorable-entities-for-tissue-engineering-applications
#8
Muraleedhara Kurup G, Sumayya A S
Marine biopolymer composite materials provide a technological platform for launching biomedical applications. Biomaterials demand good biocompatibility without the possibility of inflammation or foreign body reactions. In this study, we prepared two biocomposite hydrogels namely; HAC (hydroxyapatite, alginate & chitosan) and HACF (hydroxyapatite, alginate, chitosan & fucoidan) followed by calcium chloride cross linking. The prepared scaffolds were characterized by Fourier Transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM)...
March 11, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28286747/rapid-fabrication-of-cell-laden-alginate-hydrogel-3d-structures-by-micro-dip-coating
#9
Atabak Ghanizadeh Tabriz, Christopher G Mills, John J Mullins, Jamie A Davies, Wenmiao Shu
Development of a simple, straightforward 3D fabrication method to culture cells in 3D, without relying on any complex fabrication methods, remains a challenge. In this paper, we describe a new technique that allows fabrication of scalable 3D cell-laden hydrogel structures easily, without complex machinery: the technique can be done using only apparatus already available in a typical cell biology laboratory. The fabrication method involves micro dip-coating of cell-laden hydrogels covering the surface of a metal bar, into the cross-linking reagents calcium chloride or barium chloride to form hollow tubular structures...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28282150/ph-responsive-peptide-supramolecular-hydrogels-with-antibacterial-activity
#10
Yaoming Wan, Libing Liu, Shuaishuai Yuan, Jing Sun, Zhibo Li
Smart hydrogels have received increasing attention for many applications. Here, we synthesized a class of cationic peptide amphiphiles that can self-assemble into hydrogels by ring-opening polymerization (ROP) and post-modification strategy. The incorporation of cationic lysine residues suppress the formation of fibril-like structure and further the gelation ability of the samples. Sodium alginate (SA) is used to enhance the rheology performance of the hydrogels. The hydrogels exhibit pH-dependent self-assembling and the gelation behaviour that enables them ideal smart hydrogel system for biomedical applications...
March 10, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28280669/in-vivo-chondrogenesis-in-3d-bioprinted-human-cell-laden-hydrogel-constructs
#11
Thomas Möller, Matteo Amoroso, Daniel Hägg, Camilla Brantsing, Nicole Rotter, Peter Apelgren, Anders Lindahl, Lars Kölby, Paul Gatenholm
BACKGROUND: The three-dimensional (3D) bioprinting technology allows creation of 3D constructs in a layer-by-layer fashion utilizing biologically relevant materials such as biopolymers and cells. The aim of this study is to investigate the use of 3D bioprinting in a clinically relevant setting to evaluate the potential of this technique for in vivo chondrogenesis. METHODS: Thirty-six nude mice (Balb-C, female) received a 5- × 5- × 1-mm piece of bioprinted cell-laden nanofibrillated cellulose/alginate construct in a subcutaneous pocket...
February 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28278043/injectable-conductive-collagen-alginate-polypyrrole-hydrogels-as-a-biocompatible-system-for-biomedical-applications
#12
Farinaz Ketabat, Akbar Karkhaneh, Rouhollah Mehdinavaz Aghdam, Seyed Hossein Ahmadi Tafti
Recently, Injectable Conducting Hydrogel (ICH) systems have gained much attention for tissue engineering and regenerative medicine. These systems can promote the regeneration of tissues responding to electrical responses. In this study, a novel ICH system was introduced. To achieve this system, firstly, a soluble non-toxic polypyrrole (PPy) synthesized by grafting pyrrole on alginate (Alg) backbone (Alg-graft-PPy), and then, ICH systems were prepared by the given ratios of Alg-graft-PPy, Alg, and collagen (Col)...
March 2, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28268748/electrosynthesis-of-magnetoresponsive-microrobot-for-targeted-drug-delivery-using-calcium-alginate
#13
Chengzhi Hu, Katharina Riederer, Michael Klemmer, Salvador Pane, Bradley J Nelson
Targeted drug delivery systems deliver drugs precisely to a specific targeted site inside the body, and can also release the drugs with controlled kinetics to prolong the efficacy of single dose administration. The advantageous properties of hydrogels make them attractive for use in the area of drug delivery. Calcium alginate is a pH sensitive hydrogel stable in acidic media and soluble in basic media. This enables the hydrogel to absorb and release aqueous solutions at certain ranges of pH values. By absorbing an aqueous solution containing a drug, an active drug release can be triggered at a specified range of pH value...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268297/hydrogel-reinforced-polypyrrole-electroactuator
#14
Yongchen Wang, Bingxi Yan, Yu Wu, Liang Guo
Robust electroactuators that are lightweight, power-efficient and capable of generating high forces at a low actuation voltage are of great demand in the design of micro-electromechanical systems (MEMS) for biomedical applications. In this work, electroactive composite films of alginate hydrogel and polypyrrole/polyethylene glycol (PPy/PEG) are synthesized and characterized as actuators for driving an implantable insulin micropump. A porous and flexible alginate hydrogel back layer is used to mechanically reinforce the PPy/PEG film by enhancing the actuator's resistance to its generated tension but without increase of its overall rigidness...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267507/lanthanide-ions-induced-formation-of-hierarchical-and-transparent-polysaccharide-hybrid-films
#15
Shunli Liu, Kewen Li, Fang Yao, Liqun Xu, Guodong Fu
Nacre-like hybrid films based on N-succinyl chitosan (NSC), sodium alginate (SA) and lanthanide ions were fabricated via coordination interactions. In this work, the binary building blocks (NSC and SA) were self-assembled into aligned hydrogel films by coordination with lanthanide ions, and hierarchical NSC-SA hybrid films were obtained upon drying. Two species of lanthanide ions (Gd(3+) and Yb(3+)) were used to fabricate the hierarchical NSC-SA hybrid films. The as-prepared NSC-SA hybrid films exhibit high tensile strength and stability...
May 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28266351/biofabrication-of-a-co-culture-system-in-an-osteoid-like-hydrogel-matrix
#16
Tobias Zehnder, Aldo Boccaccini, Rainer Detsch
Biofabrication aims to develop functional, biological constructs using automated processes (additive manufacturing, AM) involving different cell types and biomaterials [1]. As bone tissue is based on the crosstalk between osteoblasts and osteoclasts at least, evaluating cell-cell and cell-material interactions is of interest to understand bone remodeling. There is increasing interest in the role of osteoclasts not only considering bone resorption, but also their influence on the proliferation, migration and differentiation of osteoblasts...
March 7, 2017: Biofabrication
https://www.readbyqxmd.com/read/28261723/boronic-acid-modified-alginate-enables-direct-formation-of-injectable-self-healing-and-multistimuli-responsive-hydrogels
#17
Asja Pettignano, Santiago Grijalvo, Marleen Häring, Ramon Eritja, Nathalie Tanchoux, Françoise Quignard, David Díaz Díaz
One-step functionalization of alginate with boronic acid groups allowed spontaneous formation of biocompatible hydrogels under basic conditions without additional complementary molecules or crosslinking agents. The dynamic nature of boronate ester bonds formed with vicinal diols present on alginate pyranose rings provided remarkable self-healing, injectable and multi-stimuli responsive properties to the material.
March 6, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28247039/alginate-a-versatile-biomaterial-to-encapsulate-isolated-ovarian-follicles
#18
Julie Vanacker, Christiani A Amorim
In vitro culture of ovarian follicles isolated or enclosed in ovarian tissue fragments and grafting of isolated ovarian follicles represent a potential alternative to restore fertility in cancer patients who cannot undergo cryopreservation of embryos or oocytes or transplantation of frozen-thawed ovarian tissue. In this regard, respecting the three-dimensional (3D) architecture of isolated follicles is crucial to maintaining their proper follicular physiology. To this end, alginate hydrogel has been widely investigated using follicles from numerous animal species, yielding promising results...
February 28, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28226936/electrosynthesis-of-magnetoresponsive-microrobot-for-targeted-drug-delivery-using-calcium-alginate
#19
Chengzhi Hu, Katharina Riederer, Michael Klemmer, Salvador Pane, Bradley J Nelson, Chengzhi Hu, Katharina Riederer, Michael Klemmer, Salvador Pane, Bradley J Nelson, Salvador Pane, Katharina Riederer, Bradley J Nelson, Michael Klemmer, Chengzhi Hu
Targeted drug delivery systems deliver drugs precisely to a specific targeted site inside the body, and can also release the drugs with controlled kinetics to prolong the efficacy of single dose administration. The advantageous properties of hydrogels make them attractive for use in the area of drug delivery. Calcium alginate is a pH sensitive hydrogel stable in acidic media and soluble in basic media. This enables the hydrogel to absorb and release aqueous solutions at certain ranges of pH values. By absorbing an aqueous solution containing a drug, an active drug release can be triggered at a specified range of pH value...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226456/hydrogel-reinforced-polypyrrole-electroactuator
#20
Yongchen Wang, Bingxi Yan, Yu Wu, Liang Guo, Yongchen Wang, Bingxi Yan, Yu Wu, Liang Guo, Yongchen Wang, Liang Guo, Bingxi Yan, Yu Wu
Robust electroactuators that are lightweight, power-efficient and capable of generating high forces at a low actuation voltage are of great demand in the design of micro-electromechanical systems (MEMS) for biomedical applications. In this work, electroactive composite films of alginate hydrogel and polypyrrole/polyethylene glycol (PPy/PEG) are synthesized and characterized as actuators for driving an implantable insulin micropump. A porous and flexible alginate hydrogel back layer is used to mechanically reinforce the PPy/PEG film by enhancing the actuator's resistance to its generated tension but without increase of its overall rigidness...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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