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alginate hydrogel

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https://www.readbyqxmd.com/read/28922717/magnetic-nanoparticle-loaded-alginate-beads-for-local-micro-actuation-of-in-vitro-tissue-constructs
#1
Awatef M Alshehri, Otto C Wilson, Bishnu Dahal, John Philip, Xiaolong Luo, Christopher B Raub
Magnetic nanoparticles (MNPs) self-align and transduce magnetic force, two properties which lead to promising applications in cell and tissue engineering. However, the toxicity of MNPs to cells which uptake them is a major impediment to applications in engineered tissue constructs. To address this problem, MNPs were embedded in millimeter-scale alginate beads, coated with glutaraldehyde cross-linked chitosan, and loaded in acellular and MDA-MB-231 cancer cell-seeded collagen hydrogels, providing local micro-actuation under an external magnetic field...
September 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28919526/chemical-crosslinking-of-biopolymeric-scaffolds-current-knowledge-and-future-directions-of-crosslinked-engineered-bone-scaffolds
#2
REVIEW
Ahmad Oryan, Amir Kamali, Ali Moshiri, Hossien Baharvand, Hamed Daemi
Bone tissue scaffolds made from either natural or synthetic polymers are employed to promote bone healing. However, lack of sufficient or poor mechanical properties such as low integrity and stability reduces their medical applications. Crosslinking, defined as induction of chemical or physical links among polymer chains, is a simple method generally used to modify mechanical, biological and degradation properties of hydrogels. Although crosslinking through chemical reactions improves the mechanical properties of bone substitutes, most of the reagents used for this aim demonstrate undesirable effects and may exert toxic reactions...
September 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28917928/cell-interactive-alginate-chitosan-biopolymer-systems-with-tunable-mechanics-and-antibody-release-rates
#3
Nathan A Fletcher, Evelyn L Von Nieda, Melissa D Krebs
This work investigates techniques to produce biocompatible hydrogels with tunable stiffness without the addition of crosslinking agents or altering cell binding sites. Alginate and water-soluble chitosan salts were used to form polyelectrolyte complexes (PECs), where the storage and loss moduli could be increased by raising gelation temperatures. The largest change, a 6.5-fold increase in storage modulus, occurred when the crosslinking temperature was increased from 37 to 50°C while using chitosan with chlorine counterions...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917911/injectable-glycosaminoglycan-protein-nano-complex-in-semi-interpenetrating-networks-a-biphasic-hydrogel-for-hyaline-cartilage-regeneration
#4
Janani Radhakrishnan, Anuradha Subramanian, Swaminathan Sethuraman
Articular hyaline cartilage regeneration remains challenging due to its less intrinsic reparability. The study develops injectable biphasic semi-interpenetrating polymer networks (SIPN) hydrogel impregnated with chondroitin sulfate (ChS) nanoparticles for functional cartilage restoration. ChS loaded zein nanoparticles (∼150nm) prepared by polyelectrolyte-protein complexation were interspersed into injectable SIPNs developed by blending alginate with poly(vinyl alcohol) and calcium crosslinking. The hydrogel exhibited interconnected porous microstructure (39...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28916741/enhancement-of-water-diffusion-and-compression-performance-of-crosslinked-alginate-films-with-a-minuscule-amount-of-graphene-oxide
#5
Ángel Serrano-Aroca, Juan-Francisco Ruiz-Pividal, Mar Llorens-Gámez
A series of calcium alginate composite hydrogels with several calcium chloride contents ranging from 3 to 18 wt.% with and without 0.1 wt.% of graphene oxide (GO) was prepared in order to study the effect of crosslinking and nanofilling on water diffusion and compression performance. Thus, for high crosslinker contents, these composite hydrogels exhibited ultrafast diffusion of liquid water and excellent compression properties as compared with control (0 wt.% GO and the same crosslinking). These remarkable results are produced due to calcium cations are able to crosslink alginate and also graphene oxide nanosheets to form large crosslinked GO networks inside the calcium alginate hydrogels...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28914533/m%C3%A3-ssbauer-spectroscopic-characterization-of-iron-iii-polysaccharide-coordination-complexes-photochemistry-biological-and-photoresponsive-materials-implications
#6
Hendrik Auerbach, Giuseppe E Giammanco, Volker Schünemann, Alexis D Ostrowski, Carl J Carrano
While polycarboxylates and hydroxyl-acid complexes have long been known to be photoactive, simple carboxylate complexes which lack a significant LMCT band are not typically strongly photoactive. Hence, it was somewhat surprising that a series of reports demonstrated that materials synthesized from iron(III) and polysaccharides such as alginate (poly[guluronan-co-mannuronan]) or pectate (poly[galacturonan]) formed photoresponsive materials that convert from hydrogels to sols under the influence of visible light...
September 15, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28914392/alginate-hyaluronic-acid-hydrogel-delivery-system-characteristics-regulate-the-differentiation-of-periodontal-ligament-stem-cells-toward-chondrogenic-lineage
#7
Sahar Ansari, Ivana M Diniz, Chider Chen, Tara Aghaloo, Benjamin M Wu, Songtao Shi, Alireza Moshaverinia
Cartilage tissue regeneration often presents a challenging clinical situation. Recently, it has been shown that Periodontal Ligament Stem Cells (PDLSCs) possess high chondrogenic differentiation capacity. In this study, we developed a stem cell delivery system based on alginate/hyaluronic acid (HA) loaded with TGF-β1 ligand, encapsulating PDLSCs; and investigated the chondrogenic differentiation of encapsulated cells in alginate/HA hydrogel microspheres in vitro and in vivo. The results showed that PDLSCs, as well as human bone marrow mesenchymal stem cells (hBMMSCs), as the positive control, were stained positive for both toluidine blue and alcian blue staining, while exhibiting high levels of gene expression related to chondrogenesis (Col II, Aggrecan and Sox-9), as assessed via qPCR...
September 15, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28911258/effect-of-cryopreservation-on-cell-laden-hydrogels-comparison-of-different-cryoprotectants
#8
Nicola Cagol, Walter Bonani, Devid Maniglio, Claudio Migliaresi, Antonella Motta
Cell encapsulation in hydrogels is a technique that offers a variety of applications, ranging from drug delivery to biofabrication of three-dimensional scaffolds. The assembly of cell-laden hydrogel building blocks aims to generate complex biological constructs by manipulating microscale units. An important issue for the clinical implementation of this technique is the long-term storage of a large stock of cell/hydrogel building blocks. In this work, the impact of cryopreservation on the viability and functionality of cells encapsulated in alginate matrices is presented comparing different cryoprotective agents (CPAs)...
September 14, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28906525/stereolithographic-printing-of-ionically-crosslinked-alginate-hydrogels-for-degradable-biomaterials-and-microfluidics
#9
Thomas M Valentin, Susan E Leggett, Po-Yen Chen, Jaskiranjeet K Sodhi, Lauren H Stephens, Hayley D McClintock, Jea Yun Sim, Ian Y Wong
3D printed biomaterials with spatial and temporal functionality could enable interfacial manipulation of fluid flows and motile cells. However, such dynamic biomaterials are challenging to implement since they must be responsive to multiple, biocompatible stimuli. Here, we show stereolithographic printing of hydrogels using noncovalent (ionic) crosslinking, which enables reversible patterning with controlled degradation. We demonstrate this approach using sodium alginate, photoacid generators and various combinations of divalent cation salts, which can be used to tune the hydrogel degradation kinetics, pattern fidelity, and mechanical properties...
September 14, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28901673/catanionic-coacervate-micro-droplets-as-a-surfactant-based-membrane-free-protocell-model
#10
Jean-Paul Douliez, Nicolas Martin, Stephen Mann, Cédric Gaillard, Thomas Beneyton, Jean-Christophe Baret, Laure Beven
We report on the formation of surfactant complex catanionic coacervate micro-droplets in mixtures of decanoic acid and cetyl pyridinium chloride or cetyl trimethyl ammonium bromide. We show that coacervation occurs over a broad range of composition, pH and ionic strength. The catanionic coacervates consist of elongated micelles, sequester a wide range of solutes including water-soluble organic dyes, polysaccharides, proteins, enzymes and DNA, and can be structurally stabilized by sodium alginate or gelatin-based hydrogelation...
September 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28895290/design-of-a-novel-two-component-hybrid-dermal-scaffold-for-the-treatment-of-pressure-sores
#11
Vaibhav Sharma, Nupur Kohli, Dale Moulding, Halimat Afolabi, Lilian Hook, Chris Mason, Elena García-Gareta
The aim of this study is to design a novel two-component hybrid scaffold using the fibrin/alginate porous hydrogel Smart Matrix combined to a backing layer of plasma polymerized polydimethylsiloxane (Sil) membrane to make the fibrin-based dermal scaffold more robust for the treatment of the clinically challenging pressure sores. A design criteria are established, according to which the Sil membranes are punched to avoid collection of fluid underneath. Manual peel test shows that native silicone does not attach to the fibrin/alginate component while the plasma polymerized silicone membranes are firmly bound to fibrin/alginate...
September 12, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28888462/control-of-protein-digestion-under-simulated-gastrointestinal-conditions-using-biopolymer-microgels
#12
Zipei Zhang, Ruojie Zhang, David Julian McClements
Controlling the rate and extent of protein digestion within different regions of the human gastrointestinal tract (GIT) is important for regulating hormonal responses (such as hunger, satiety, and satiation) and immune responses (such as allergenicity). In this study, hydrogel beads (biopolymer microgels) were fabricated by injecting a solution of anionic alginate molecules into a solution of cationic calcium ions using a vibrating extrusion device. A model food protein (whey protein isolate, WPI) was mixed with the alginate solution prior to bead formation...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28888067/injectable-thermosensitive-alginate-%C3%AE-tricalcium-phosphate-aspirin-hydrogels-for-bone-augmentation
#13
Xiaoqian Fang, Lei Lei, Ting Jiang, Ying Chen, Yunqing Kang
In this study, an injectable and thermo-sensitive alginate/β-tricalcium phosphate hydrogel (TSAH/β-TCP) was prepared for aspirin release to a bone defect. Aspirin was dissolved into a mixture of poly(N-isopropylacrylamide) (PNIPAAm), an aminated alginate-g-PNIPAAm co-polymer, and β-TCP powders. Scanning electron microscopy showed that TSAH/β-TCP had an interconnected porous microstructure with a porosity of 86.78%. The cross-linked hydrogel released approximately 40% of the aspirin in the first 3 days and then slowly released the remainder...
September 9, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28875559/alginate-hydrogels-of-varied-molecular-weight-distribution-enable-sustained-release-of-sphingosine-1-phosphate-and-promote-angiogenesis
#14
Priscilla A Williams, Kevin T Campbell, Eduardo A Silva
Alginate hydrogels have been widely validated for controlled release of growth factors and cytokines, but studies exploring sustained release of small hydrophobic lipids are lacking. Sphingosine-1-phosphate (S1P), a bioactive lipid, is an appealing small molecule for inducing blood vessel formation in the context of ischemic conditions. However, there are numerous biological and engineering challenges associated with designing biomaterial systems for controlled release of this lipid. Thus, the objective of this study was to design an injectable, alginate hydrogel formulation that provides controlled release of S1P to establish locally sustained concentration gradients that promote neovascularization...
September 5, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28873701/encapsulation-of-omega-3-fatty-acids-in-nanoemulsions-and-microgels-impact-of-delivery-system-type-and-protein-addition-on-gastrointestinal-fate
#15
Fang Chen, Guang-Qin Fan, Zipei Zhang, Ruojie Zhang, Ze-Yuan Deng, David Julian McClements
Carefully designed delivery systems are required to encapsulate and protect omega-3 fatty acids in commercial food and beverage products, but then release them at the required site-of-action within the human gastrointestinal tract (GIT). Previously, we showed that the oxidative stability of flaxseed oil (a plant-based source of omega-3 fatty acids) encapsulated in nanoemulsion droplets or calcium alginate microgels (hydrogel beads) was improved using caseinate as a natural antioxidant. In this study, the impact of caseinate on the digestion of flaxseed oil encapsulated in these delivery systems was investigated using a simulated GIT...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28866170/printability-study-of-hydrogel-solution-extrusion-in-nanoclay-yield-stress-bath-during-printing-then-gelation-biofabrication
#16
Yifei Jin, Wenxuan Chai, Yong Huang
Yield-stress support bath-enabled extrusion printing is emerging as a promising filament-based direct-write strategy for different applications in tissue engineering and regenerative medicine. Central to the printing quality of complex three-dimensional structures fabricated by the support bath-enabled fabrication approach is the formation of a continuous filament with well-defined geometry. The objective of this research is to study the printability of hydrogel precursor solutions in a Laponite nanoclay yield-stress bath during extrusion printing where the printed hydrogel precursor solutions remain liquid...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28864249/hydrogel-substrate-stress-relaxation-regulates-the-spreading-and-proliferation-of-mouse-myoblasts
#17
Aline Bauer, Luo Gu, Brian Kwee, Aileen Li, Maxence Dellacherie, Adam D Celiz, David J Mooney
Mechanical properties of the extracellular microenvironment are known to alter cellular behavior, such as spreading, proliferation or differentiation. Previous studies have primarily focused on studying the effect of matrix stiffness on cells using hydrogel substrates that exhibit purely elastic behavior. However, these studies have neglected a key property exhibited by the extracellular matrix (ECM) and various tissues; viscoelasticity and subsequent stress-relaxation. As muscle exhibits viscoelasticity, stress-relaxation could regulate myoblast behavior such as spreading and proliferation, but this has not been previously studied...
August 29, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28862424/injectable-macroporous-ferrogel-microbeads-with-a-high-structural-stability-for-magnetically-actuated-drug-delivery
#18
Bom Yi Shin, Bong Geun Cha, Ji Hoon Jeong, Jaeyun Kim
Macroporous hydrogels are an attractive material platform that can provide shortened interfacial diffusion pathways and high biomacromolecule loading. Recently, macroporous ferrogels have shown high potential for use in the on-demand delivery of bioactive molecules, resulting from their reversible and large volumetric deformation upon magnetic stimulation. However, these macroporous ferrogels require surgical placement in the body due to their large size; an injectable form of macroporous ferrogels has not yet been reported...
September 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28861646/nanocomposite-particles-with-improved-microstructure-for-3d-culture-systems-and-bone-regeneration
#19
Sergiu Cecoltan, Izabela-Cristina Stancu, Diana Maria Drăguşin, Andrada Serafim, Adriana Lungu, Cătălin Ţucureanu, Iuliana Caraş, Vlad Constantin Tofan, Aurora Sălăgeanu, Eugeniu Vasile, Romain Mallet, Daniel Chappard, Cristin Coman, Mircea Istodorescu, Horia Iovu
Nano-apatite and gelatin-alginate hydrogel microparticles have been prepared by a one-step synthesis combined with electrostatic bead generation, for the reconstruction of bone defects. Based on the analysis of bone composition, architecture and embryonic intramembranous ossification, a bio-inspired fabrication has been developed. Accordingly, the mineral phase has been in situ synthesized, calcifying the hydrogel matrix while the latter was crosslinked, finally generating microparticles that can assemble into a bone defect to ensure interconnected pores...
August 31, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28859901/use-of-hydrogel-scaffolds-to-develop-an-in-vitro-3d-culture-model-of-human-intestinal-epithelium
#20
R H Dosh, A Essa, N Jordan-Mahy, C Sammon, C L Le Maitre
The human intestinal cell lines: Caco-2 and HT29-MTX cells have been used extensively in 2D and 3D cell cultures as simple models of the small intestinal epithelium in vitro. This study aimed to investigate the potential of three hydrogel scaffolds to support the 3D culture of Caco-2 and HT29-MTX cells and critically assess their use as scaffolds to stimulate villi formation to model a small intestinal epithelium in vitro. Here, alginate, L-pNIPAM, and L-pNIPAM-co-DMAc hydrogels were investigated. The cells were suspended within or layered on these hydrogels and maintained under static or dynamic culture conditions for up to 21 days...
August 28, 2017: Acta Biomaterialia
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