Yin Liu, Li Li, Xuan Li, Hosni Cherif, Shuaibing Jiang, Farshid Ghezelbash, Michael H Weber, David Juncker, Nicole Y K Li-Jessen, Lisbet Haglund, Jianyu Li
Low back pain is a leading cause of disability worldwide, often attributed to intervertebral disc (IVD) degeneration with loss of the functional nucleus pulposus (NP). Regenerative strategies utilizing biomaterials and stem cells are promising for NP repair. Human NP tissue is highly viscoelastic, relaxing stress rapidly under deformation. However, the impact of tissue-specific viscoelasticity on the activities of adipose-derived stem cells (ASC) remains largely unexplored. Here, we investigated the role of matrix viscoelasticity in regulating ASC differentiation for IVD regeneration...
April 12, 2024: Acta Biomaterialia