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alginate hydrogel

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https://www.readbyqxmd.com/read/28226936/electrosynthesis-of-magnetoresponsive-microrobot-for-targeted-drug-delivery-using-calcium-alginate
#1
Chengzhi Hu, Katharina Riederer, Michael Klemmer, Salvador Pane, Bradley J Nelson, Chengzhi Hu, Katharina Riederer, Michael Klemmer, Salvador Pane, Bradley J Nelson, Salvador Pane, Katharina Riederer, Bradley J Nelson, Michael Klemmer, Chengzhi Hu
Targeted drug delivery systems deliver drugs precisely to a specific targeted site inside the body, and can also release the drugs with controlled kinetics to prolong the efficacy of single dose administration. The advantageous properties of hydrogels make them attractive for use in the area of drug delivery. Calcium alginate is a pH sensitive hydrogel stable in acidic media and soluble in basic media. This enables the hydrogel to absorb and release aqueous solutions at certain ranges of pH values. By absorbing an aqueous solution containing a drug, an active drug release can be triggered at a specified range of pH value...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226456/hydrogel-reinforced-polypyrrole-electroactuator
#2
Yongchen Wang, Bingxi Yan, Yu Wu, Liang Guo, Yongchen Wang, Bingxi Yan, Yu Wu, Liang Guo, Yongchen Wang, Liang Guo, Bingxi Yan, Yu Wu
Robust electroactuators that are lightweight, power-efficient and capable of generating high forces at a low actuation voltage are of great demand in the design of micro-electromechanical systems (MEMS) for biomedical applications. In this work, electroactive composite films of alginate hydrogel and polypyrrole/polyethylene glycol (PPy/PEG) are synthesized and characterized as actuators for driving an implantable insulin micropump. A porous and flexible alginate hydrogel back layer is used to mechanically reinforce the PPy/PEG film by enhancing the actuator's resistance to its generated tension but without increase of its overall rigidness...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224886/alginate-hydrogels-modified-with-low-molecular-weight-hyaluronate-for-cartilage-regeneration
#3
Honghyun Park, Hyun Ji Lee, Hyoseok An, Kuen Yong Lee
Alginate is a typical biomaterial that forms hydrogels in the presence of calcium ions and has often been utilized in tissue engineering approaches. However, it lacks biofunctionality in the form of interactions with cells and proteins. Hyaluronate, a main component of glycosaminoglycans, provides CD44-specific interactions with chondrocytes but typically requires chemical cross-linking agents to fabricate hydrogels, which may cause unexpected side effects in the body. In this study, we propose the design and fabrication of a hybrid structure of alginate and hyaluronate useful for cartilage regeneration...
April 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28219689/in-vitro-drug-release-profiles-of-ph-sensitive-hydroxyethylacryl-chitosan-sodium-alginate-hydrogels-using-paracetamol-as-a-soluble-model-drug
#4
Pitchaya Treenate, Pathavuth Monvisade
The aim of this study is to investigate in vitro drug release profiles of pH-sensitive hydrogels composed of hydroxyethylacryl chitosan (HC) and sodium alginate (SA). The hydrogels were crosslinked by dipping method using different ionic crosslinkers (e.g., Ca(2+), Zn(2+) and Cu(2+)). The crosslinking reaction was confirmed by FT-IR. Swelling behavior and stability of the hydrogels in simulated digestive media were investigated. The result indicated that the combination between HC and SA could delay the degradation time of the hydrogels...
February 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28218329/dopamine-assisted-fixation-of-drug-loaded-polymeric-multilayers-to-osteoarticular-implants-for-tuberculosis-therapy
#5
Dan Li, Litao Li, Yunlong Ma, Yaping Zhuang, Dawei Li, Hong Shen, Xing Wang, Fei Yang, Yuanzheng Ma, Decheng Wu
Currently, the major issues in the treatment of osteoarticular tuberculosis (TB) after implant placement are low drug concentration at the infected focus and drug resistance resulting from the long-term chemotherapy. The application of drug-loaded polymeric multilayers on implantable devices offers a promising solution to the problems. Herein, a poly(ethylene glycol)-based hydrogel film embedded with isoniazid (INH)-loaded alginate microparticles was fixed to Ti implants via adhesive polydopamine, subsequently capped by poly(lactic-co-glycolic acid) membranes for the sustained and localized delivery of the anti-TB drug...
February 20, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28199952/biopolymer-gold-nanoparticles-composite-plasmonic-thermal-history-indicator-to-monitor-quality-and-safety-of-perishable-bioproducts
#6
Yi-Cheng Wang, Lin Lu, Sundaram Gunasekaran
Quality and safety of perishable products such as foods, pharmaceutics, and biologicals is a constant concern. We have developed a plasmonic thermal history indicator (THI) taking advantage of the localized surface plasmon resonance of gold nanoparticles (AuNPs) synthesized in situ in alginate, a natural polysaccharide. The color of the THIs becomes more intense with increased storage temperature and/or duration, with the color changing from grey to red with time of exposure at high temperature (40°C). The results suggest that decreasing viscosity with increasing number of AuNPs being synthesized in the system, along with aggregation of newly synthesized AuNPs onto larger ones and their settling are potentially responsible for the distinct color change observed...
January 26, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28197209/effect-of-bmp-2-delivery-mode-on-osteogenic-differentiation-of-stem-cells
#7
Taekhee Jung, John Hwan Lee, Soonjung Park, Yong-Jin Kim, Joseph Seo, Hye-Eun Shim, Ki-Suk Kim, Hyon-Seok Jang, Hyung-Min Chung, Seong-Geun Oh, Sung-Hwan Moon, Sun-Woong Kang
Differentiation of stem cells is an important strategy for regeneration of defective tissue in stem cell therapy. Bone morphogenetic protein-2 (BMP-2) is a well-known osteogenic differentiation factor that stimulates stem cell signaling pathways by activating transmembrane type I and type II receptors. However, BMPs have a very short half-life and may rapidly lose their bioactivity. Thus, a BMP delivery system is required to take advantage of an osteoinductive effect for osteogenic differentiation. Previously, BMP delivery has been designed and evaluated for osteogenic differentiation, focusing on carriers and sustained release system for delivery of BMPs...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28196382/bromelain-loading-and-release-from-a-hydrogel-formulated-using-alginate-and-arabic-gum
#8
Janaína Artem Ataide, Letícia Caramori Cefali, Marcia de Araujo Rebelo, Lívia Genovez Spir, Elias Basile Tambourgi, Angela Faustino Jozala, Marco Vinícius Chaud, Edgar Silveira, Xiaochen Gu, Priscila Gava Mazzola
An ideal wound dressing ensures a moist environment around the wound area and absorbs exudates from the wound surface. Topical application of bromelain to incised wounds has been shown to reprogram the wound microenvironment to promote effective tissue repair. Combining the characteristics of hydrogels and bromelain is therefore of great interest. Herein, we describe the development of a hydrogel, formulated using alginate and Arabic gum, for bromelain loading and release. The hydrogel formulation was evaluated using response surface methodology, considering the pH value and the concentration of alginate and Arabic gum...
February 14, 2017: Planta Medica
https://www.readbyqxmd.com/read/28192295/assessment-of-alginate-hydrogel-degradation-in-biological-tissue-using-viscosity-sensitive-fluorescent-dyes
#9
Tatiana V Shkand, Mykola O Chizh, Iryna V Sleta, Borys P Sandomirsky, Anatoliy L Tatarets, Leonid D Patsenker
The main goal of this study is to investigate a combination of viscosity-sensitive and viscosity-insensitive fluorescent dyes to distinguish different rheological states of hydrogel based biostructural materials and carriers in biological tissues and to assess their corresponding location areas. The research is done in the example of alginate hydrogel stained with viscosity-sensitive dyes Seta-470 and Seta-560 as well as the viscosity-insensitive dye Seta-650. These dyes absorb/emit at 469/518, 565/591 and 651/670 nm, respectively...
September 28, 2016: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28189069/multitarget-sensing-of-glucose-and-cholesterol-based-on-janus-hydrogel-microparticles
#10
Xiao-Ting Sun, Ying Zhang, Dong-Hua Zheng, Shuai Yue, Chun-Guang Yang, Zhang-Run Xu
A visualized sensing method for glucose and cholesterol was developed based on the hemispheres of the same Janus hydrogel microparticles. Single-phase and Janus hydrogel microparticles were both generated using a centrifugal microfluidic chip. For glucose sensing, concanavalin A and fluorescein labeled dextran used for competitive binding assay were encapsulated in alginate microparticles, and the fluorescence of the microparticles was positively correlated with glucose concentration. For cholesterol sensing, the microparticles embedded with γ-Fe2O3 nanoparticles were used as catalyst for the oxidation of 3,3',5,5'-Tetramethylbenzidine by H2O2, an enzymatic hydrolysis product of cholesterol...
February 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28187519/development-of-a-novel-alginate-polyvinyl-alcohol-hydroxyapatite-hydrogel-for-3d-bioprinting-bone-tissue-engineered-scaffolds
#11
Stephanie T Bendtsen, Sean P Quinnell, Mei Wei
3D printed biomaterials used as personalized tissue substitutes have the ability to promote and enhance regeneration in areas of defected tissue. The challenge with 3D printing for bone tissue engineering remains the selection of a material with optimal rheological properties for printing in addition to biocompatibility and capacity for uniform cell incorporation. Hydrogel biomaterials may provide sufficient printability to allow cell encapsulation and bioprinting of scaffolds with uniform cell distribution...
February 10, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28183657/production-and-in-vitro-evaluation-of-macroporous-cell-encapsulating-alginate-fibres-for-nerve-repair
#12
Sharon Chien-Yu Lin, Yiwei Wang, David F Wertheim, Allan G A Coombes
The prospects for successful peripheral nerve repair using fibre guides are considered to be enhanced by the use of a scaffold material, which promotes attachment and proliferation of glial cells and axonal regeneration. Macroporous alginate fibres were produced by extraction of gelatin particle porogens from wet spun fibres produced using a suspension of gelatin particles in 1.5% w/v alginate solution. Gelatin loading of the starting suspension of 40.0, 57.0, and 62.5% w/w resulted in gelatin loading of the dried alginate fibres of 16, 21, and 24% w/w respectively...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28176951/in-vitro-and-in-vivo-evaluation-of-biologically-synthesized-silver-nanoparticles-for-topical-applications-effect-of-surface-coating-and-loading-into-hydrogels
#13
Aml I Mekkawy, Mohamed A El-Mokhtar, Nivien A Nafady, Naeima Yousef, Mostafa A Hamad, Sohair M El-Shanawany, Ehsan H Ibrahim, Mahmoud Elsabahy
In the present study, silver nanoparticles (AgNPs) were synthesized via biological reduction of silver nitrate using extract of the fungus Fusarium verticillioides (green chemistry principle). The synthesized nanoparticles were spherical and homogenous in size. AgNPs were coated with polyethylene glycol (PEG) 6000, sodium dodecyl sulfate (SDS), and β-cyclodextrin (β-CD). The averaged diameters of AgNPs were 19.2±3.6, 13±4, 14±4.4, and 15.7±4.8 nm, for PEG-, SDS-, and β-CD-coated and uncoated AgNPs, respectively...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28171847/fabrication-of-cell-benign-inverse-opal-hydrogels-for-three-dimensional-cell-culture
#14
Pilseon Im, Dong Hwan Ji, Min Kyung Kim, Jaeyun Kim
Inverse opal hydrogels (IOHs) for cell culture were fabricated and optimized using calcium-crosslinked alginate microbeads as sacrificial template and gelatin as a matrix. In contrast to traditional three-dimensional (3D) scaffolds, the gelatin IOHs allowed the utilization of both the macropore surface and inner matrix for cell co-culture. In order to remove templates efficiently for the construction of 3D interconnected macropores and to maintain high cell viability during the template removal process using EDTA solution, various factors in fabrication, including alginate viscosity, alginate concentration, alginate microbeads size, crosslinking calcium concentration, and gelatin network density were investigated...
May 15, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28170076/biomimetic-sulphated-alginate-hydrogels-suppress-il-1%C3%AE-induced-inflammatory-responses-in-human-chondrocytes
#15
Ø Arlov, M Steinwachs, G Skjåk-Bræk, M Zenobi-Wong
Loss of articular cartilage from ageing, injury or degenerative disease is commonly associated with inflammation, causing pain and accelerating degradation of the cartilage matrix. Sulphated glycosaminoglycans (GAGs) are involved in the regulation of immune responses in vivo, and analogous polysaccharides are currently being evaluated for tissue engineering matrices to form a biomimetic environment promoting tissue growth while suppressing inflammatory and catabolic activities. Here, we characterise physical properties of sulphated alginate (S-Alg) gels for use in cartilage engineering scaffolds, and study their anti-inflammatory effects on encapsulated chondrocytes stimulated with IL-1β...
February 7, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28161663/is-there-a-cause-and-effect-relationship-between-physicochemical-properties-and-cell-behavior-of-alginate-based-hydrogel-obtained-after-sterilization
#16
Hao Yu, Ghislaine Cauchois, Jean-François Schmitt, Nicolas Louvet, Jean-Luc Six, Yun Chen, Rachid Rahouadj, Céline Huselstein
Alginate-based hydrogel scaffolds are widely used in the field of cartilage regeneration and repair. If the effect of autoclaving on the alginate powder is well known, it is not the same for the possible effects of the sterilization UV treatment on the properties of the hydrogel after polymerization. To select an effective sterilization treatment of alginate-based materials, one must find what are inter-relationship between the characteristics (chemical, physical and mechanical) of alginate-based hydrogel during sterilization, and what consequences have affected on cell behavior...
January 25, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28157608/formation-of-novel-hydrogel-bio-anode-by-immobilization-of-biocatalyst-in-alginate-polyaniline-titanium-dioxide-graphite-composites-and-its-electrical-performance
#17
Attila Szöllősi, Ágoston Hoschke, Judit M Rezessy-Szabó, Erika Bujna, Szilárd Kun, Quang D Nguyen
A new bio-anode containing gel-entrapped bacteria in alginate/polyaniline/TiO2/graphite composites was constructed and electrically investigated. Alginate as dopant and template as well as entrapped gel was used for immobilization of microorganism cells. Increase of polyaniline concentration resulted an increase in the conductivity in gels. Addition of 0.01 and 0.02 g/mL polyaniline caused 6-fold and 10-fold higher conductivity, respectively. Furthermore, addition of 0.05 g/mL graphite powder caused 10-fold higher conductivity and 4-fold higher power density, respectively...
May 2017: Chemosphere
https://www.readbyqxmd.com/read/28157291/continuous-fabrication-and-assembling-of-spatial-cell-laden-fibers-for-tissue-like-construct-via-photolithographic-based-microfluidic-chip
#18
Dan Wei, Jing Sun, Jason Bolderson, Meiling Zhong, Matthew John Dalby, Maggie Cusack, Huabing Yin, Hongsong Fan, Xingdong Zhang
Engineering three-dimensional scaffolds with in vivo-like architecture and function has shown great potential for tissue regeneration. Here we developed a facile microfluidic-based strategy for continuous fabrication of cell-laden microfibers with hierarchically organised architecture. We show that photolithographically fabricated microfluidic devices offer a simple and reliable way to create anatomically inspired complex structures. Furthermore, the use of photocrosslinkable methacrylated alginate allows modulation of both mechanical properties and biological activity of the hydrogels for targeted applications...
February 3, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28143741/orally-targeted-delivery-of-tripeptide-kpv-via-hyaluronic-acid-functionalized-nanoparticles-efficiently-alleviates-ulcerative-colitis
#19
Bo Xiao, Zhigang Xu, Emilie Viennois, Yuchen Zhang, Zhan Zhang, Mingzhen Zhang, Moon Kwon Han, Yuejun Kang, Didier Merlin
Overcoming adverse effects and selectively delivering drug to target cells are two major challenges in the treatment of ulcerative colitis (UC). Lysine-proline-valine (KPV), a naturally occurring tripeptide, has been shown to attenuate the inflammatory responses of colonic cells. Here, we loaded KPV into hyaluronic acid (HA)-functionalized polymeric nanoparticles (NPs). The resultant HA-KPV-NPs had a desirable particle size (∼272.3 nm) and a slightly negative zeta potential (∼-5.3 mV). These NPs successfully mediated the targeted delivery of KPV to key UC therapy-related cells (colonic epithelial cells and macrophages)...
January 28, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28142500/hyaluronic-acid-collagen-hydrogel-as-an-alternative-to-alginate-for-long-term-immunoprotected-islet-transplantation
#20
Stephen Harrington, S Janette Williams, Sonia Rawal, Karthik Ramachandran, Lisa Stehno-Bittel
Alginate has long been the material of choice for immunoprotection of islets for its low cost and ability to easily form microspheres. Unfortunately, this seaweed-derived material is notoriously prone to fibrotic overgrowth in vivo, resulting in premature graft failure. The purpose of this study was to test an alternative, hyaluronic acid (HA-COL), for in vitro function, viability and allogeneic islet transplant outcomes in diabetic rats. In vitro studies indicated that the HA-COL gel had diffusion characteristics that would allow small molecules like glucose and insulin to enter and exit the gel, while larger molecules (70 and 500kD dextrans) were impeded from diffusing past the gel edge in 24 hours...
January 31, 2017: Tissue Engineering. Part A
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