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alginate hydrogel

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https://www.readbyqxmd.com/read/29765422/the-effect-of-pulsatile-flow-on-bmsc-derived-endothelial-like-cells-in-a-small-sized-artificial-vessel-made-by-3-dimensional-bioprinting
#1
Kang Woog Lee, Dae-Hyun Kim, Jun Hee Lee, Young-Nam Youn
Replacement of small-sized vessels is still challenging. This study is aimed at investigating the possibility of small-sized artificial vessels made by 3-dimensional bioprinting and the effect of pulsatile flow on bMSC-derived endothelial-like cells. Cells were harvested from rabbit bone marrow and primary cultured with or without growth factors. Endothelial differentiation was confirmed by the Matrigel tube formation assay, Western blot, and qRT-PCR. In addition, embedment of endothelial-like cells in an artificial vessel was made by 3-dimensional bioprinting, and the pulsatile flow was performed...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29765421/retention-and-functional-effect-of-adipose-derived-stromal-cells-administered-in-alginate-hydrogel-in-a-rat-model-of-acute-myocardial-infarction
#2
Bjarke Follin, Adam Ali Ghotbi, Andreas Ettrup Clemmensen, Simon Bentsen, Morten Juhl, Rebekka Harary Søndergaard, Lisbeth Drozd Lund, Mandana Haack-Sørensen, Philip Hasbak, Smadar Cohen, Rasmus Sejersten Ripa, Jens Kastrup, Annette Ekblond, Andreas Kjær
Background: Cell therapy for heart disease has been proven safe and efficacious, despite poor cell retention in the injected area. Improving cell retention is hypothesized to increase the treatment effect. In the present study, human adipose-derived stromal cells (ASCs) were delivered in an in situ forming alginate hydrogel following acute myocardial infarction (AMI) in rats. Methods: ASCs were transduced with luciferase and tested for ASC phenotype. AMI was inducted in nude rats, with subsequent injection of saline (controls), 1 × 106 ASCs in saline or 1 × 106 ASCs in 1% ( w / v ) alginate hydrogel...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29764304/prednisolone-loaded-coatable-polyvinyl-alcohol-alginate-hydrogel-for-the-treatment-of-atopic-dermatitis
#3
Hye Ri Lee, Tae Ho Kim, Se Heang Oh, Jin Ho Lee
Atopic dermatitis (AD) is a chronic inflammatory skin disease resulting pruritic, erythema, edema, excoriation, and thickening of the skin, and thus leads to significant impairment in the patient's life. The objective of this study is to develop a steroid drug [prednisolone (PS)]-loaded coatable hydrogel for the treatment of AD. PS-loaded hydrogel was composed of PVA entrapped in mildly crosslinked alginate (PS-loaded PVA/ALG hydrogel). The PS concentration to be loaded in the hydrogel that takes AD efficacy without cell necrosis was determined from the cytotoxicity test using human dermal fibroblasts...
May 15, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29763774/precisely-controlled-delivery-of-magnesium-ions-thru-sponge-like-monodisperse-plga-nano-mgo-alginate-core-shell-microsphere-device-to-enable-in-situ-bone-regeneration
#4
Zhengjie Lin, Jun Wu, Wei Qiao, Ying Zhao, Karen H M Wong, Paul K Chu, Liming Bian, Shuilin Wu, Yufeng Zheng, Kenneth M C Cheung, Frankie Leung, Kelvin W K Yeung
A range of magnesium ions (Mg2+ ) used has demonstrated osteogenic tendency in vitro. Hence, we propose to actualize this concept by designing a new system to precisely control the Mg2+ delivery at a particular concentration in vivo in order to effectively stimulate in-situ bone regeneration. To achieve this objective, a monodisperse core-shell microsphere delivery system comprising of poly (lactic-co-glycolic acid) (PLGA) biopolymer, alginate hydrogel, and magnesium oxide nano-particles has been designed by using customized microfluidic capillary device...
May 8, 2018: Biomaterials
https://www.readbyqxmd.com/read/29760452/quantifying-compressive-forces-between-living-cell-layers-and-within-tissues-using-elastic-round-microgels
#5
Erfan Mohagheghian, Junyu Luo, Junjian Chen, Gaurav Chaudhary, Junwei Chen, Jian Sun, Randy H Ewoldt, Ning Wang
Increasing evidence shows that mechanical stresses are critical in regulating cell functions, fate, and diseases. However, no methods exist that can quantify isotropic compressive stresses. Here we describe fluorescent nanoparticle-labeled, monodisperse elastic microspheres made of Arg-Gly-Asp-conjugated alginate hydrogels (elastic round microgels, ERMGs). We generate 3D displacements and calculate strains and tractions exerted on an ERMG. Average compressive tractions on an ERMG are 570 Pa within cell layers and 360 Pa in tumor-repopulating cell (TRC) colonies grown in 400-Pa matrices...
May 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29756517/local-controlled-release-in-vivo-of-vascular-endothelial-growth-factor-within-a-subcutaneous-scaffolded-islet-implant-reduces-early-islet-necrosis-and-improves-performance-of-the-graft
#6
John A Gebe, Anton Preisinger, Michel D Gooden, Leonard A D'Amico, Robert B Vernon
Islet transplantation remains the only alternative to daily insulin therapy for control of type 1 diabetes (T1D) in humans. To avoid the drawbacks of intrahepatic islet transplantation, we are developing a scaffolded islet implant to transplant islets into nonhepatic sites. The implant test bed, sized for mice, consists of a limited (2-mm) thickness, large-pore polymeric sponge scaffold perforated with peripheral cavities that contain islets suspended in a collagen hydrogel. A central cavity in the scaffold holds a 2-mm diameter alginate sphere for controlled release of the angiogenic cytokine vascular endothelial growth factor ( VEGF)...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29753183/rheological-behavior-of-ph-responsive-composite-hydrogels-of-chitosan-and-alginate-characterization-and-its-use-in-encapsulation-of-citral
#7
Saima Afzal, Masrat Maswal, Aijaz Ahmad Dar
The pure and composite hydrogels of chitosan with sodium alginate were synthesized at various pH values and characterized by rheology and IR-spectroscopy. Chitosan shows gelation at neutral and basic pH while sodium alginate remains in solution form at all pH values. By careful adjustment of mixing weight fraction ratio and pH, an array of hydrogels with modulated structural dynamics and viscoelasticity, mechanical strength and encapsulation capacity were obtained. At acidic pH, a higher weight fraction of alginate increased the elasticity of the hydrogels while at basic pH more percentage of chitosan stabilized the hydrogel...
May 2, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29752862/nanoceria-loaded-injectable-hydrogels-for-potential-age-related-macular-degeneration-treatment
#8
Kai Wang, Rajendra Narayan Mitra, Min Zheng, Zongchao Han
The major purpose of this article is to evaluate oligochitosan coated cerium oxide nanoparticles (OCCNPs) alginate laden injectable hydrogels and their potential treatment for age-related macular degeneration (AMD). The water soluble OCCNPs were loaded within injectable hydrogels as antioxidative agents. The release of OCCNPs from hydrogel, radical scavenging properties, and biocompatibility were evaluated and calculated in vitro. The effects of OCCNP laden hydrogel downregulating expression of angiogenic proteins and pro-inflammatory cytokines were quantified in human retinal pigment epithlium-19 (ARPE-19) and umbilical endothelium cell lines...
May 12, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29752097/self-crosslinking-effect-of-chitosan-and-gelatin-on-alginate-based-hydrogels-injectable-in-situ-forming-scaffolds
#9
Ziba Naghizadeh, Akbar Karkhaneh, Arash Khojasteh
Injectable in situ forming hydrogels has great potential in tissue engineering. Simple and easy preparation of these hydrogels with low toxicity and stability is a great advantage. In the present study, two types of self-crosslinking in situ forming alginate based hydrogels with different formulation were synthesized, characterized and compared in order to introduce an optimal injectable scaffold in minimally invasive applications in tissue engineering. To this end, the hydrogels consist of oxidized alginate (AD), polyethylene glycol (PEG) and carboxymethyl chitosan (CMC) or gelatin (GEL) was synthesized...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29751036/guar-gum-blended-alginate-agarose-hydrogel-as-a-promising-support-for-the-entrapment-of-peroxidase-stability-and-reusability-studies-for-the-treatment-of-textile-effluent
#10
Misha Ali, Qayyum Husain
Ginger peroxidase (GP) was entrapped into the hydrogels of guar gum (GG)-alginate/agarose and these immobilized GP preparations were employed for the treatment of textile effluent. GG is a natural hydrophilic polysaccharide which may form complex with enzyme increasing its molecular dimension that can be easily retained inside the entrapping support. Therefore, the activity retention by alginate-guar gum (ANGG) and agarose-guar gum (AGG) was higher than that of alginate and agarose alone. Scanning electron microscopy (SEM) analysis also revealed that GG-GP complex was successfully entrapped inside the alginate/agarose gels...
May 8, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29749707/automated-expansion-of-primary-human-t-cells-in-scalable-and-cell-friendly-hydrogel-microtubes-for-adoptive-immunotherapy
#11
Haishuang Lin, Qiang Li, Ou Wang, Jack Rauch, Braden Harm, Hendrik J Viljoen, Chi Zhang, Erika Van Wyk, Chi Zhang, Yuguo Lei
Adoptive immunotherapy is a highly effective strategy for treating many human cancers, such as melanoma, cervical cancer, lymphoma, and leukemia. Here, a novel cell culture technology is reported for expanding primary human T cells for adoptive immunotherapy. T cells are suspended and cultured in microscale alginate hydrogel tubes (AlgTubes) that are suspended in the cell culture medium in a culture vessel. The hydrogel tubes protect cells from hydrodynamic stresses and confine the cell mass less than 400 µm (in radial diameter) to ensure efficient mass transport, creating a cell-friendly microenvironment for growing T cells...
May 11, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29749078/softening-and-shape-morphing-of-stiff-tough-hydrogels-by-localized-unlocking-of-the-trivalent-ionically-cross-linked-centers
#12
Jiahui Wang, Tianzhen Li, Fan Chen, Dan Zhou, Baijia Li, Xiaohu Zhou, Tiansheng Gan, Stephan Handschuh-Wang, Xuechang Zhou
The mechanical properties (e.g., stiffness, stretchability) of prefabricated hydrogels are of pivotal importance for diverse applications in tissue engineering, soft robotics, and medicine. This study reports a feasible method to fabricate ultrasoft and highly stretchable structures from stiff and tough hydrogels of low stretchability and the application of these switchable hydrogels in programmable shape-morphing systems. Stiff and tough hydrogel structures are first fabricated by the mechanical strengthening of Ca2+ -alginate/polyacrylamide tough hydrogels by addition of Fe3+ ions, which introduces Fe3+ ionically cross-linked centers into the Ca2+ divalent cross-linked hydrogel, forming an additional and much less flexible trivalent ionically cross-linked network...
May 11, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29744457/alginate-nanobeads-interspersed-fibrin-network-as-in-situ-forming-hydrogel-for-soft-tissue-engineering
#13
S Deepthi, R Jayakumar
Hydrogels are a class of materials that has the property of injectability and in situ gel formation. This property of hydrogels is manipulated in this study to develop a biomimetic bioresorbable injectable system of alginate nanobeads interspersed in fibrin network. Alginate nanobeads developed by calcium cross-linking yielded a size of 200-500 nm. The alginate nanobeads fibrin hydrogel was formed using dual syringe apparatus. Characterization of the in situ injectable hydrogel was done by SEM, FTIR and Rheometer...
June 2018: Bioactive Materials
https://www.readbyqxmd.com/read/29736573/semi-ipn-and-ipn-based-hydrogels
#14
Nicole Zoratto, Pietro Matricardi
Semi-interpenetrating polymer networks (semi-IPNs) and interpenetrating polymeric networks (IPNs) have emerged as innovative materials for biomedical and pharmaceutical applications. The interest in these structures is due to the possibility of combining the favorable properties of each polymeric component of the IPNs or semi-IPNs leading to a new system with properties that often differ from those of the two single components. In this respect, polysaccharides represent an opportunity in this field, combining a general biocompatibility and a good availability...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29733514/injectable-hydrogels-for-cardiac-tissue-engineering
#15
REVIEW
Brisa Peña, Melissa Laughter, Susan Jett, Teisha J Rowland, Matthew R G Taylor, Luisa Mestroni, Daewon Park
In light of the limited efficacy of current treatments for cardiac regeneration, tissue engineering approaches have been explored for their potential to provide mechanical support to injured cardiac tissues, deliver cardio-protective molecules, and improve cell-based therapeutic techniques. Injectable hydrogels are a particularly appealing system as they hold promise as a minimally invasive therapeutic approach. Moreover, injectable acellular alginate-based hydrogels have been tested clinically in patients with myocardial infarction (MI) and show preservation of the left ventricular (LV) indices and left ventricular ejection fraction (LVEF)...
May 7, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29729598/graphene-oxide-encapsulated-polyvinyl-alcohol-sodium-alginate-hydrogel-microspheres-for-cu-ii-and-u-vi-removal
#16
Xiaofeng Yi, Fuliang Sun, Zhenhua Han, Fuhao Han, Jiarui He, Minrui Ou, Junjie Gu, Xiaoping Xu
In this work, a novel sodium alginate (SA)/polyvinyl alcohol (PVA)/graphene oxide (GO) hydrogel microspheres were prepared by a simple method. Sodium alginate was physically crosslinked by Ca2+ ; GO was encapsulated into the composite to strengthen the hydrogels; PVA played a significant role in well dispersing of GO in SA. The SA/PVA/GO (SPG) hydrogels were employed as an efficient adsorbent for removal of Cu (II) and U (VI) from aqueous solution. Batch experiments with the subject of the pH, initial metal ion concentration, competing ions and contact time were investigated...
May 2, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29719134/an-intelligent-neural-stem-cell-delivery-system-for-neurodegenerative-diseases-treatment
#17
Shupei Qiao, Yi Liu, Fengtong Han, Mian Guo, Xiaolu Hou, Kangruo Ye, Shuai Deng, Yijun Shen, Yufang Zhao, Haiying Wei, Bing Song, Lifen Yao, Weiming Tian
Transplanted stem cells constitute a new therapeutic strategy for the treatment of neurological disorders. Emerging evidence indicates that a negative microenvironment, particularly one characterized by the acute inflammation/immune response caused by physical injuries or transplanted stem cells, severely impacts the survival of transplanted stem cells. In this study, to avoid the influence of the increased inflammation following physical injuries, an intelligent, double-layer, alginate hydrogel system is designed...
May 2, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29715595/design-of-a-vascularized-synthetic-poly-ethylene-glycol-macroencapsulation-device-for-islet-transplantation
#18
Jessica D Weaver, Devon M Headen, Michael D Hunckler, Maria M Coronel, Cherie L Stabler, Andrés J García
The use of immunoisolating macrodevices in islet transplantation confers the benefit of safety and translatability by containing transplanted cells within a single retrievable device. To date, there has been limited development and characterization of synthetic poly(ethylene glycol) (PEG)-based hydrogel macrodevices for islet encapsulation and transplantation. Herein, we describe a two-component synthetic PEG hydrogel macrodevice system, designed for islet delivery to an extrahepatic islet transplant site, consisting of a hydrogel core cross-linked with a non-degradable PEG dithiol and a vasculogenic outer layer cross-linked with a proteolytically sensitive peptide to promote degradation and enhance localized vascularization...
April 25, 2018: Biomaterials
https://www.readbyqxmd.com/read/29708307/inkjet-spray-hybrid-printing-for-3d-freeform-fabrication-of-multilayered-hydrogel-structures
#19
Sejeong Yoon, Ju An Park, Hwa-Rim Lee, Woong Hee Yoon, Dong Soo Hwang, Sungjune Jung
Here, a new bioprinting process by combining drop-on-demand inkjet printing with a spray-coating technique, which enables the high-resolution, high-speed, and freeform fabrication of large-scale cell-laden hydrogel structures is reported. Hydrogel structures with various shapes and composed of different materials, including alginate, cellulose nanofiber, and fibrinogen, are fabricated using the inkjet-spray printing. To manufacture cell-friendly hydrogel structures with controllable stiffness, gelatine methacryloyl is saponified to stabilize jet formation and is subsequently mixed with sodium alginate to prepare blend inks...
April 30, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29704742/magnetic-hydrogels-for-levodopa-release-and-cell-stimulation-triggered-by-external-magnetic-field
#20
Stalin Kondaveeti, Ana Teresa Silva Semeano, Daniel R Cornejo, Henning Ulrich, Denise Freitas Siqueira Petri
Magnetic responsive hydrogels composed of alginate (Alg) and xanthan gum (XG), crosslinked with Ca2+ ions, were modified by in situ magnetic nanoparticles (MNP) formation. In comparison to magnetic Alg hydrogels, magnetic Alg-XG hydrogels presented superior mechanical and swelling properties, due to the high charge density and molecular weight of XG. The loading efficiency of levodopa (LD), an important antiparkinson drug, in the Alg-XG/MNP hydrogels was the highest (64%), followed by Alg/MNP (56%), Alg-XG (53%) and Alg (28%)...
April 22, 2018: Colloids and Surfaces. B, Biointerfaces
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