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alginate hydrogel

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https://www.readbyqxmd.com/read/28448789/development-of-pre-implantation-porcine-blastocysts-cultured-within-alginate-hydrogel-systems-either-supplemented-with-secreted-phosphoprotein-1-or-conjugated-with-arg-gly-asp-peptide
#1
Taylor D Laughlin, Jeremy R Miles, Elane C Wright-Johnson, Lea A Rempel, Clay A Lents, Angela K Pannier
Although deficiencies in porcine blastocyst elongation play a significant role in early embryonic mortality and establishment of within-litter developmental variation, the exact mechanisms of elongation are poorly understood. Secreted phosphoprotein 1 (SPP1) is increased within the uterine milieu during early porcine pregnancy and contains an Arg-Gly-Asp (RGD) peptide sequence that binds to cell surface integrins on the uterine endometrium and trophectoderm, promoting cell adhesion and migration. The aim of the present study was to evaluate the development of preimplantation porcine blastocysts encapsulated and cultured within alginate hydrogels either supplemented with SPP1 or conjugated with RGD...
April 28, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28440042/biodegradable-hydrogel-based-biomaterials-with-high-absorbent-properties-for-non-adherent-wound-dressing
#2
Alok Kumar, Xiang Wang, Krishna Chaitanya Nune, Rdk Misra
Dressing materials involve conventional gauzes and modern materials such as hydrogels and foam-based biomaterials. Although the choice of dressing material depends on the type of wound, a dressing material is expected to be non-cytotoxic. Additionally, moist dressing is considered appropriate to accelerate epithelialisation, while dry dressing may cause tissue damage during removal. An ideal dressing material is expected to provide a moist environment and degrade and release the drug for faster wound healing...
April 25, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28436920/hybrid-3d-printing-and-electrodeposition-approach-for-controllable-3d-alginate-hydrogel-formation
#3
Wanfeng Shang, Yanting Liu, Wenfeng Wan, Chengzhi Hu, Zeyang Liu, Chin To Wong, Toshio Fukuda, Yajing Shen
Calcium alginate hydrogel is one of the most widely used biocompatible materials in biomedical and tissue engineering. This paper reports a hybrid 3D printing and electrodeposition approach to form the 3D calcium alginate hydrogel in a controllable manner. Firstly, a specific 3D printing system is developed by combining a 3D printer and a customized ejection syringe. Then, the mixed solution (1% w/v sodium alginate and 0.25% w/v CaCO3 nano particles) is filled in the syringe and ejected out from the nozzle to the substrate continuously...
April 24, 2017: Biofabrication
https://www.readbyqxmd.com/read/28436503/stimuli-responsive-hydrogel-microfibers-with-controlled-anisotropic-shrinkage-and-cross-sectional-geometries
#4
Shunsuke Nakajima, Ryuji Kawano, Hiroaki Onoe
Stimuli-responsive microfibers are fabricated by extruding mixed solutions of poly(N-isopropylacrylamide-co-acrylic acid) (pNIPAM-AAc) and sodium alginate (Na-alginate) using a microfluidic spinning system. The fabricated microfibers shrink and swell with temperature and/or pH. By controlling the extruded laminar flow, microfibers capable of anisotropic shrinkage are fabricated. Cross-sectional microscale geometries of microfibers, including double layering and hollowness, are successfully controlled by patterning the laminar flow during microfiber formation, resulting in hydrogels capable of folding/unfolding motions and fluid pumping...
April 24, 2017: Soft Matter
https://www.readbyqxmd.com/read/28436224/multi-functional-hydrogels-prepared-by-dual-ion-crosslinking-for-chronic-wound-healing
#5
Yonghui Li, Yan Han, Xiaoya Wang, Jinliang Peng, Yuhong Xu, Jiang Chang
The creation of moist environment and promotion of blood vessel formation are critical for wound healing. Sodium alginate (SA) hydrogel, which has good biocompatibility and is able to provide moist environment, has been widely used as wound dressing. However, it lacks antibacterial and bio-activities, which would facilitate chronic wound healing. On the basis of gelation characteristics of SA and the bioactive hardystonite (HS) bioceramic, we designed a unique bioactive injectable composite hydrogel through double ion-crosslinking, in which divalent ions such as Ca2+ and Zn2+ function as crosslinkers, Zn2+ also functions as antibacterial component and nutrition for wound healing, and Si ions play the key role in determining the bioactivity of the hydrogel...
April 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28432956/introduction-of-n-cadherin-binding-motif-to-alginate-hydrogels-for-controlled-stem-cell-differentiation
#6
Jae Won Lee, Hyoseok An, Kuen Yong Lee
Control of stem cell fate and phenotype using biomimetic synthetic extracellular matrices (ECMs) is an important tissue engineering approach. Many studies have focused on improving cell-matrix interactions. However, proper control of cell-cell interactions using synthetic ECMs could be critical for tissue engineering, especially with undifferentiated stem cells. In this study, alginate hydrogels were modified with a peptide derived from the low-density lipoprotein receptor-related protein 5 (LRP5), which is known to bind to N-cadherin, as a cell-cell interaction motif...
April 9, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28429415/rod-shaped-neural-units-for-aligned-3d-neural-network-connection
#7
Midori Kato-Negishi, Hiroaki Onoe, Akane Ito, Shoji Takeuchi
This paper proposes neural tissue units with aligned nerve fibers (called rod-shaped neural units) that connect neural networks with aligned neurons. To make the proposed units, 3D fiber-shaped neural tissues covered with a calcium alginate hydrogel layer are prepared with a microfluidic system and are cut in an accurate and reproducible manner. These units have aligned nerve fibers inside the hydrogel layer and connectable points on both ends. By connecting the units with a poly(dimethylsiloxane) guide, 3D neural tissues can be constructed and maintained for more than two weeks of culture...
April 21, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28421735/a-self-healable-and-cold-resistant-supercapacitor-based-on-a-multifunctional-hydrogel-electrolyte
#8
Feng Tao, Liming Qin, Zhikui Wang, Qinmin Pan
Excellent self-healability and cold-resistance are attractive properties for a portable/wearable energy-storage device. However, achieving the features is fundamentally dependent on an intrinsically self-healable electrolyte with high ionic conduction at low temperature. Here we report such a hydrogel electrolyte comprising sodium alginate cross-linked by dynamic catechol-borate ester bonding. Since its dynamically cross-linked alginate network can tolerate high content inorganic salts, the electrolyte possesses excellent healing efficiency/cyclability but also high ionic conduction at both room temperature and low temperature...
April 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28417597/ultrahigh-water-content-superelastic-and-shape-memory-nanofiber-assembled-hydrogels-exhibiting-pressure-responsive-conductivity
#9
Yang Si, Lihuan Wang, Xueqin Wang, Ning Tang, Jianyong Yu, Bin Ding
High-water-content hydrogels that are both mechanically robust and conductive could have wide applications in fields ranging from bioengineering and electronic devices to medicine; however, creating such materials has proven to be extremely challenging. This study presents a scalable methodology to prepare superelastic, cellular-structured nanofibrous hydrogels (NFHs) by combining alginate and flexible SiO2 nanofibers. This approach causes naturally abundant and sustainable alginate to assemble into 3D elastic bulk NFHs with tunable water content and desirable shapes on a large scale...
April 18, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28415545/engineering-bone-regeneration-with-novel-cell-laden-hydrogel-microfiber-injectable-calcium-phosphate-scaffold
#10
Yang Song, Chi Zhang, Ping Wang, Lin Wang, Chunyun Bao, Michael D Weir, Mark A Reynolds, Ke Ren, Liang Zhao, Hockin H K Xu
Cell-based tissue engineering is promising to create living functional tissues for bone regeneration. The implanted cells should be evenly distributed in the scaffold, be fast-released to the defect and maintain high viability in order to actively participate in the regenerative process. Herein, we report an injectable calcium phosphate cement (CPC) scaffold containing cell-encapsulating hydrogel microfibers with desirable degradability that could deliver cells in a timely manner and maintain cell viability...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28412794/-effects-of-alginate-collagen-scaffold-on-cell-proliferation-and-differentiation-of-human-adipose-derived-mesenchymal-stem-cells
#11
W Cheng, X P Han, S L Mou, F Yang, L P Liu
Objective: To build scaffold materials with different concentrations of alginate and collagen, and to observe the effects of alginate/collagen ratio on the proliferation of human adipose-derived mesenchymal stem cells (hAMSC) and osteogenic differentiation. The optimal concentration of alginate/collagen will be chosen for constructing hydrogel that will be used for bone tissue engineering. Methods: Soluble hydrogel scaffold materials containing alginate/collagen were prepared, and the following groups were established based on different alginate/collagen ratio: 4∶1 (group A), 2∶1 (group B), and 1∶1 (group C)...
April 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/28411548/the-production-of-injectable-hydrazone-crosslinked-gellan-gum-hyaluronan-hydrogels-with-tunable-mechanical-and-physical-properties
#12
Jennika Karvinen, Janne T Koivisto, Ilari Jönkkäri, Minna Kellomäki
Gellan gum (GG) has been proposed for use in tissue engineering (TE) due to its structural and functional similarities with alginate. The most traditional crosslinking methods of GG, ionical and photocrosslinking, have downsides such as loss of stability or phototoxicity, which can limit their use in certain applications. In this study, an alternative hydrazone crosslinking method is introduced. Hydrazone crosslinking is a simple method that produces no toxic reagents or side-products. The method enables the fabrication of injectable hydrogels...
April 7, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28407335/in-vitroporcine-blastocyst-development-in-three-dimensional-alginate-hydrogels
#13
REVIEW
Jeremy R Miles, Taylor D Laughlin, Catherine N Sargus-Patino, Angela K Pannier
Appropriate embryonic and fetal development significantly impact pregnancy success and, therefore, the efficiency of swine production. The pre-implantation period of porcine pregnancy is characterized by several developmental hallmarks, which are initiated by the dramatic morphological change that occurs as pig blastocysts elongate from spherical to filamentous blastocysts. Deficiencies in blastocyst elongation contribute to approximately 20% of embryonic loss, and have a direct influence on within-litter birth weight variation...
April 13, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28392379/formation-and-cleaning-function-of-physically-cross-linked-dual-strengthened-water-soluble-chitosan-based-core-shell-particles
#14
Yanrui Dong, Congming Xiao
Facile and mild ionic cross-linking and freezing/thawing technologies were applied to prepare double strengthened core-shell particles by using water-soluble chitosan (WSC), sodium alginate (SA) and poly(vinyl alcohol) (PVA) as starting materials. The aqueous solution contained WSC and PVA was dropped in ethanol to form beads. The beads were converted into WSC/PVA hydrogel particles by being subjected to three freeze/thaw cycles. Subsequently, ionic cross-linked hydrogel layer was formed around each WSC/PVA particle to generate core-shell particulates...
April 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28391767/alginate-based-microcapsules-generated-with-the-coaxial-electrospray-method-for-clinical-application
#15
Catherine Barron, Jia-Qiang He
Alginate-based microencapsulation of cells has made a significant impact on the fields of regenerative medicine and tissue engineering mainly because of its ability to provide immunoisolation for the encapsulated material. This characteristic has allowed for the successful transplantation of non-autologous cells in several clinical trials for life threatening conditions, such as diabetes, myocardial infarction, and neurodegenerative disorders. Methods for alginate hydrogel microencapsulation have been well developed for various types of cells and can generate microcapsules of different diameters, degradation time, and composition...
April 20, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28385446/dental-and-orofacial-mesenchymal-stem-cells-in-craniofacial-regeneration-the-prosthodontist-s-point-of-view
#16
REVIEW
Sahar Ansari, Jackson T Seagroves, Chider Chen, Kumar Shah, Tara Aghaloo, Benjamin M Wu, Sompop Bencharit, Alireza Moshaverinia
Of the available regenerative treatment options, craniofacial tissue regeneration using mesenchymal stem cells (MSCs) shows promise. The ability of stem cells to produce multiple specialized cell types along with their extensive distribution in many adult tissues have made them an attractive target for applications in tissue engineering. MSCs reside in a wide spectrum of postnatal tissue types and have been successfully isolated from orofacial tissues. These dental- or orofacial-derived MSCs possess self-renewal and multilineage differentiation capacities...
April 3, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28385222/alginate-polyvinyl-alcohol-based-interpenetrating-polymer-network-for-prolonged-drug-therapy-optimization-and-in-vitro-characterization
#17
Hina Anwar, Mahmood Ahmad, Muhammad Usman Minhas, Sahrish Rehmani
A new natural and synthetic polymeric blend to form interpenetrating polymer network (IPN) hydrogels was synthesized utilizing sodium alginate and PVA as polymers by free radical polymerization employing 2-Acylamido-2-methylpropane-sulfonic acid as monomer (AMPS) and tramadol HCl as model drug through 3(2) level full factorial design to evaluate the impact of selected independent factors i.e. polymer (sodium alginate) and monomer (AMPS) contents on swelling index at 18th hour, percent drug release at 18th hour, time required for 80% drug release and drug entrapment efficiency as dependent variables...
June 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28382640/subnanomolar-detection-of-oligonucleotides-through-templated-fluorogenic-reaction-in-hydrogels-controlling-diffusion-to-improve-sensitivity
#18
Dana Al Sulaiman, Jason Y H Chang, Sylvain Ladame
Oligonucleotide-templated reactions are valuable tools for nucleic acid sensing both in vitro and in vivo. They are typically carried out under conditions that make any reaction in the absence of template highly unfavorable (most commonly by using a low concentration of reactants), which has a negative impact on the detection sensitivity. Herein, we report a novel platform for fluorogenic oligonucleotide-templated reactions between peptide nucleic acid probes embedded within permeable agarose and alginate hydrogels...
May 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28378803/functionalized-core-shell-hydrogel-microsprings-by-anisotropic-gelation-with-bevel-tip-capillary
#19
Koki Yoshida, Hiroaki Onoe
This study describes a novel microfluidic-based method for the synthesis of hydrogel microsprings that are capable of encapsulating various functional materials. A continuous flow of alginate pre-gel solution can spontaneously form a hydrogel microspring by anisotropic gelation around the bevel-tip of the capillary. This technique allows fabrication of hydrogel microsprings using only simple capillaries and syringe pumps, while their complex compartmentalization characterized by a laminar flow inside the capillary can contribute to the optimization of the microspring internal structure and functionality...
April 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28373047/sodium-alginate-and-gum-acacia-hydrogels-of-zinc-oxide-nanoparticles-reduce-hemolytic-and-oxidative-stress-inflicted-by-zinc-oxide-nanoparticles-on-mammalian-cells
#20
R Raguvaran, Anju Manuja, Balvinder K Manuja, T Riyesh, Sandeep Singh, M Kesavan, U Dimri
Zinc oxide nanoparticles are important nanomaterials currently under research due to their applicability in nanomedicine. Toxicity of ZnO NPs has been extensively studied and has been shown to affect various cell types and animal systems. In this study, we investigated hemolytic potential and oxidative stress inflicted by ZnO NPs and ZnO NPs-loaded-sodium alginate-gum acacia hydrogels on horse erythrocytes and African green monkey kidney (Vero) cells. Our study provides a better understanding of the hemolytic and oxidative effects of interaction of ZnO NPs and ZnO NPs released from polymeric hydrogels with the biological system...
March 31, 2017: International Journal of Biological Macromolecules
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