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alginate hydrogel

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https://www.readbyqxmd.com/read/29341264/a-facile-method-to-fabricate-anisotropic-hydrogels-with-perfectly-aligned-hierarchical-fibrous-structures
#1
Md Tariful Islam Mredha, Yun Zhou Guo, Takayuki Nonoyama, Tasuku Nakajima, Takayuki Kurokawa, Jian Ping Gong
Natural structural materials (such as tendons and ligaments) are comprised of multiscale hierarchical architectures, with dimensions ranging from nano- to macroscale, which are difficult to mimic synthetically. Here a bioinspired, facile method to fabricate anisotropic hydrogels with perfectly aligned multiscale hierarchical fibrous structures similar to those of tendons and ligaments is reported. The method includes drying a diluted physical hydrogel in air by confining its length direction. During this process, sufficiently high tensile stress is built along the length direction to align the polymer chains and multiscale fibrous structures (from nano- to submicro- to microscale) are spontaneously formed in the bulk material, which are well-retained in the reswollen gel...
January 17, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29320372/a-dentin-derived-hydrogel-bioink-for-3d-bioprinting-of-cell-laden-scaffolds-for-regenerative-dentistry
#2
Avathamsa Athirasala, Anthony Tahayeri, Greeshma Thrivikraman, Cristiane M França, Nelson Monteiro, Victor Tran, Jack Ferracane, Luiz E Bertassoni
Recent studies in tissue engineering have adopted extracellular matrix (ECM) derived scaffolds as natural and cytocompatible microenvironments for tissue regeneration. The dentin matrix, specifically, has been shown to be associated with a host of soluble and insoluble signaling molecules that can promote odontogenesis. Here, we have developed a novel bioink, blending printable alginate (3% w/v) hydrogels with the soluble and insoluble fractions of the dentin matrix. We have optimized the printing parameters and the concentrations of the individual components of the bioink for print accuracy, cell viability and odontogenic potential...
January 10, 2018: Biofabrication
https://www.readbyqxmd.com/read/29319535/scalable-and-physiologically-relevant-microenvironments-for-human-pluripotent-stem-cell-expansion-and-differentiation
#3
Qiang Li, Haishuang Lin, Qian Du, Kan Liu, Ou Wang, Catelyn Antionette Evans, Hannah Marie Christian, Chi Zhang, Yuguo Lei
Human pluripotent stem cells (hPSCs) are required in large numbers for various biomedical applications. However, the scalable and cost-effective culturing of high quality hPSCs and their derivatives remains very challenging. Here, we report a novel and physiologically relevant 3D culture system (called the AlgTube cell culture system) for hPSC expansion and differentiation. With this system, cells are processed into and cultured in microscale alginate hydrogel tubes that are suspended in the cell culture medium in a culture vessel...
January 10, 2018: Biofabrication
https://www.readbyqxmd.com/read/29316854/highly-stretchable-ha-sa-hydrogels-for-tissue-engineering
#4
Chengcheng Zhu, Rui Yang, Xiaobin Hua, Hong Chen, Jumei Xu, Rile Wu, Lian Cen
A highly stretchable hyaluronic acid (HA)/sodium alginate (SA) hydrogel was developed in this study based on an interpenetrating polymer network. HA/SA hydrogels were prepared by mixing two polysaccharides followed by covalent crosslinking via epoxy groups on HA molecules and ionic crosslinking via divalent ions on SA chains sequentially. The effect of HA/SA ratio on the pore size and distribution, swelling ratio, elongation and rheological properties as well as protein loading and release properties of HA/SA hydrogels was explored...
January 10, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29313334/design-of-phase-changeable-and-injectable-alginate-hydrogel-for-imaging-guided-tumor-hyperthermia-and-chemotherapy
#5
Jiulong Zhao, Jialing Li, Chunping Zhu, Fei Hu, Hongyu Wu, Xiaohua Man, Zhaoshen Li, Changqing Ye, Duowu Zou, Shige Wang
The objective of the present study was to construct an alginate (AG) phase-changeable and injectable hydrogel for imaging-guided tumor hyperthermia and chemotherapy. Based on the binding between the α-L-guluronic blocks of AG and calcium ions, the AG/MoS2/Bi2S3-PEG (MBP)/doxorubicin (DOX) solution formed a cross-linked hydrogel to simultaneously encapsulate MBP nanosheets and DOX within the hydrogel matrix. The in situ-formed hydrogel can act as a reservoir to control the release of entrapped drug molecules, and the doped MBP nanosheets and DOX can realize computed tomography/photoacoustic dual-modal imaging-guided in vivo tumor PTT and chemotherapy, respectively...
January 9, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29304429/mechanical-behaviour-of-alginate-gelatin-hydrogels-for-3d-bioprinting
#6
Michael Di Giuseppe, Nicholas Law, Braeden Webb, Ryley A Macrae, Lawrence J Liew, Timothy B Sercombe, Rodney J Dilley, Barry J Doyle
Hydrogels comprised of alginate and gelatin have demonstrated potential as biomaterials in three dimensional (3D) bioprinting applications. However, as with all hydrogel-based biomaterials used in extrusion-based bioprinting, many parameters influence their performance and there is limited data characterising the behaviour of alginate-gelatin (Alg-Gel) hydrogels. Here we investigated nine Alg-Gel blends by varying the individual constituent concentrations. We tested samples for printability and print accuracy, compressive behaviour and change over time, and viability of encapsulated mesenchymal stem cells in bioprinted constructs...
December 21, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29304023/insulin-inclusion-into-a-tragacanth-hydrogel-an-oral-delivery-system-for-insulin
#7
Mokhamad Nur, Todor Vasiljevic
Nanoparticles or microparticles created by physical complexation between two polyelectrolytes may have a prospective use as an excipient for oral insulin administration. Natural polymers such as tragacanth, alginate, dextran, pullulan, hyaluronic acid, gelatin and chitosan can be potential candidates for this purpose. In this research, insulin particles were prepared by the inclusion of insulin into a tragacanth hydrogel. The effect of the pH and concentration relationship involving polyelectrolytes offering individual particle size and zeta potential was assessed by zetasizer and scanning electron microscopy (SEM)...
January 5, 2018: Materials
https://www.readbyqxmd.com/read/29295623/superior-antifouling-capability-of-hydrogel-forward-osmosis-membrane-for-treating-wastewaters-with-high-concentration-of-organic-foulants
#8
Detao Qin, Zhaoyang Liu, Zhi Liu, Hongwei Bai, Darren Delai Sun
Wastewaters with high concentrations of organic pollutants pose a great challenge for membrane filtration due to their severe fouling propensity. In this study, a hydrogel forward osmosis (FO) membrane is explored for treating wastewaters of high concentration organic pollutants. This FO membrane has an ultrathin hydrogel selective layer, which is highly hydrophilic (water contact angle: as low as 18°) and smooth (surface roughness: <5 nm). Investigated with typical organic foulants (protein, alginate, humic acid, and oil) of high concentration (2000 ~ 20000 mg/L), this hydrogel FO membrane exhibits remarkably superior antifouling capability, with its water flux decline ratio lower than a quarter of commercial FO membrane's under identical experimental conditions...
January 3, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29285989/synthesis-and-functionalization-of-chitosan-built-hydrogel-with-induced-hydrophilicity-for-extended-release-of-sparingly-soluble-drugs
#9
Faheem Ullah, Fatima Javed, Mbh Othman, Abbas Khan, Rukhsana Gul, Zulkifli Ahmad, Hazizan Md Akil
Addressing the functional biomaterials as next-generation therapeutics, chitosan and alginic acid were copolymerized in the form of chemically crosslinked interpenetrating networks (IPNs). The native hydrogel was functionalized via carbodiimide (EDC), catalyzed coupling of soft ligand (1,2-Ethylenediamine) and hard ligand (4-aminophenol) to replace -OH groups in alginic acid units for extended hydrogel- interfaces with the aqueous and sparingly soluble drug solutions. The chemical structure, Lower solution critical temperature (LCST ≈ 37...
December 29, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29279393/designing-a-retrievable-and-scalable-cell-encapsulation-device-for-potential-treatment-of-type-1-diabetes
#10
Duo An, Alan Chiu, James A Flanders, Wei Song, Dahua Shou, Yen-Chun Lu, Lars G Grunnet, Louise Winkel, Camilla Ingvorsen, Nicolaj Strøyer Christophersen, Johannes Josef Fels, Fredrik Wolfhagen Sand, Yewei Ji, Ling Qi, Yehudah Pardo, Dan Luo, Meredith Silberstein, Jintu Fan, Minglin Ma
Cell encapsulation has been shown to hold promise for effective, long-term treatment of type 1 diabetes (T1D). However, challenges remain for its clinical applications. For example, there is an unmet need for an encapsulation system that is capable of delivering sufficient cell mass while still allowing convenient retrieval or replacement. Here, we report a simple cell encapsulation design that is readily scalable and conveniently retrievable. The key to this design was to engineer a highly wettable, Ca2+-releasing nanoporous polymer thread that promoted uniform in situ cross-linking and strong adhesion of a thin layer of alginate hydrogel around the thread...
December 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29262253/a-single-droplet-multiplex-bioassay-on-a-robust-and-stretchable-extreme-wetting-substrate-through-vacuum-based-droplet-manipulation
#11
Heetak Han, Jung Seung Lee, Hyunchul Kim, Sera Shin, Jaehong Lee, Jongchan Kim, Xu Hou, Seung-Woo Cho, Jungmok Seo, Taeyoon Lee
Herein, a droplet manipulation system with a superamphiphobic (SPO)-superamphiphilic (SPI) patterned polydimethylsiloxane (PDMS) substrate is developed for a multiplex bioassay from single-droplet samples. The SPO substrate is fabricated by sequential spraying of adhesive and fluorinated silica nanoparticles onto a PDMS substrate. It is subsequently subjected to oxygen plasma with a patterned mask to form SPI patterns. The SPO layer exhibits extreme liquid repellency with a high contact angle (>150°) towards low-surface-tension and viscous biofluidic droplets (e...
December 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/29240313/deconvolution-of-images-from-3d-printed-cells-in-layers-on-a-chip
#12
Sean Yu, Pranav Joshi, Yi Ju Park, Kyeong-Nam Yu, Moo-Yeal Lee
Layer-by-layer cell printing is useful in mimicking layered tissue structures inside the human body and has great potential for being a promising tool in the field of tissue engineering, regenerative medicine, and drug discovery. However, imaging human cells cultured in multiple hydrogel layers in 3D-printed tissue constructs is challenging as the cells are not in a single focal plane. Although confocal microscopy could be a potential solution for this issue, it compromises the throughput which is a key factor in rapidly screening drug efficacy and toxicity in pharmaceutical industries...
December 14, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/29239747/functional-testing-on-engineered-cartilage-to-identify-the-role-played-by-shearing
#13
Ling Wang, Hao Shen, Jichang Nie, Dichen Li, Hongbin Fan, Zhongmin Jin, Chaozong Liu
Compressive loading is crucial for tissue regeneration in cartilage; however, the role played by shearing induced from translational or rotational motion of the knee joint has yet to be identified. This study aims at investigating the effects of in vivo like dynamic load-compression integrated with shearing on tissue regeneration, particularly to identify the role played by shearing induced from rotational motion. Tissue samples fabricated from a calcium alginate hydrogel embedded with chondrocytes were subjected to a dynamic tissue culture...
November 24, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29236765/chondrocytes-and-stem-cells-in-3d-bioprinted-structures-create-human-cartilage-in-vivo
#14
Peter Apelgren, Matteo Amoroso, Anders Lindahl, Camilla Brantsing, Nicole Rotter, Paul Gatenholm, Lars Kölby
Cartilage repair and replacement is a major challenge in plastic reconstructive surgery. The development of a process capable of creating a patient-specific cartilage framework would be a major breakthrough. Here, we described methods for creating human cartilage in vivo and quantitatively assessing the proliferative capacity and cartilage-formation ability in mono- and co-cultures of human chondrocytes and human mesenchymal stem cells in a three-dimensional (3D)-bioprinted hydrogel scaffold. The 3D-bioprinted constructs (5 × 5 × 1...
2017: PloS One
https://www.readbyqxmd.com/read/29235375/chitosan-nanoparticles-loaded-hydrogels-promote-skin-wound-healing-through-the-modulation-of-reactive-oxygen-species
#15
Tao Wang, Yan Zheng, Yaping Shen, Yijie Shi, Fang Li, Chang Su, Liang Zhao
This study developed a novel bioactive chitosan nanoparticle loaded calcium alginate hydrogel to regulate inflammation and neovascularization for accelerated wound healing in vivo. It was found that chitosan nanoparticles loaded calcium alginate hydrogel exhibited remarkable antibacterial activity. Through the modulation of generation of ROS, it promoted the synthesis and secretion of IL-6 in vascular endothelial cell (VEC), suggesting its potential proinflammatory activation. Further, it promoted VEC invasion, metastasis and neovascularization to accelerate wound healing...
December 13, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29230560/non-functionalized-soft-alginate-hydrogel-promotes-locomotor-recovery-after-spinal-cord-injury-in-a-rat-hemimyelonectomy-model
#16
Kerim Hakan Sitoci-Ficici, Marina Matyash, Ortrud Uckermann, Roberta Galli, Elke Leipnitz, Robert Later, Chrysanthy Ikonomidou, Michael Gelinsky, Gabriele Schackert, Matthias Kirsch
BACKGROUND: Spinal cord injury (SCI) and the consecutive devastating neurological sequelae have an enormous individual and economic impact. Implantation of functionalized hydrogels is a promising approach, because they can serve as a matrix for the regenerating tissue, carry and release bioactive molecules and various cell types. We already demonstrated that non-functionalized soft alginate hydrogel supported axonal outgrowth and protected neurons against oxidative stress in vitro. Here, we investigated the effects of such soft alginate hydrogels on locomotor recovery in small and large spinal cord lesions...
December 11, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29228474/controlled-electrospray-generation-of-non-spherical-alginate-microparticles
#17
Morteza Jeyhani, Sze Yi Mak, Stephen Sammut, Ho Cheung Shum, Dae Kun Hwang, Scott Tsai
Electrospraying is a technique used to generate microparticles in a high throughput manner. For biomedical applications, a biocompatible electrosprayed material is often desirable. Using polymers, such as alginate hydrogels, makes it possible to create biocompatible and biodegradable microparticles that can be used for cell encapsulation, to be employed as drug carriers, and for use in 3D cell culturing. Evidence in the literature suggests that the morphology of the biocompatible microparticles is relevant in controlling the dynamics of the microparticles in drug delivery and 3D cell culturing applications...
December 11, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29223037/a-microfabricated-platform-for-the-study-of-chondrogenesis-under-different-compressive-loads
#18
Reza Kowsari-Esfahan, Azadeh Jahanbakhsh, Mohammad Said Saidi, Shahin Bonakdar
Microfluidic devices are beneficial in miniaturizing and multiplexing various cellular assays in a single platform. Chondrogenesis is known to pertain to chemical, topographical, and mechanical cues in the microenvironment. Mechanical cues themselves have numerous parameters such as strain magnitude, frequency, and stimulation time. Effects of different strain magnitudes on the chondrogenic differentiation of adult stem cells have not been explored thoroughly. Here, a new multilayer microdevice is presented for the unidirectional compressive stimulation of cells in a three-dimensional cell culture...
December 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29219743/building-a-polysaccharide-hydrogel-capsule-delivery-system-for-control-release-of-ibuprofen
#19
Zhi Chen, Ting Wang, Qing Yan
Development of a delivery system which can effectively carry hydrophobic drugs and have pH response is becoming necessary. Here we demonstrate that through preparation of β-cyclodextrin polymer (β-CDP), a hydrophobic drug molecule of ibuprofen (IBU) was incorporated into our prepared β-CDP inner cavities, aiming to improve the poor water solubility of IBU. A core-shell capsule structure has been designed for achieving the drug pH targeted and sustained release. This delivery system was built with polysaccharide polymer of Sodium alginate (SA), sodium carboxymethylcellulose (CMC) and hydroxyethyl cellulose (HEC) by physical cross-linking...
December 8, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29217184/formulation-of-novel-chitosan-guargum-based-hydrogels-for-sustained-drug-release-of-paracetamol
#20
Amtul Jamil Sami, Madeeha Khalid, Tahir Jamil, Saira Aftab, Sermad Ahmad Mangat, A R Shakoori, S Iqbal
The report presents the formulation of hydrogel based on biopolymers chitosan and guar gum after cross-linking for sustained release of a commonly used orally prescribed analgesic Paracetamol. The oral ingestion of Paracetamol is associated with complications of the gastric tract and liver metabolism that can be effectually avoided by using transdermal drug delivery systems. The formulated transdermal patch was characterized by physicochemical properties including swelling, bonding pattern (using FTIR Fourier Transform Infra-Red and Scanning Electron Microscopy SEM) and antimicrobial activity...
December 4, 2017: International Journal of Biological Macromolecules
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