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alginate hydrogel

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https://www.readbyqxmd.com/read/27904998/alginate-chitosan-hydrogels-provide-a-sustained-gradient-of-sphingosine-1-phosphate-for-therapeutic-angiogenesis
#1
Priscilla A Williams, Kevin T Campbell, Hessam Gharaviram, Justin L Madrigal, Eduardo A Silva
Sphingosine-1-phosphate (S1P), a bioactive lipid, is a potent candidate for treatment of ischemic vascular disease. However, designing biomaterial systems for the controlled release of S1P to achieve therapeutic angiogenesis presents both biological and engineering challenges. Thus, the objective of this study was to design a hydrogel system that provides controlled and sustained release of S1P to establish local concentration gradients that promote neovascularization. Alginate hydrogels have been extensively studied and characterized for delivery of proangiogenic factors...
November 30, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27897217/self-healing-polysaccharide-based-hydrogels-as-injectable-carriers-for-neural-stem-cells
#2
Zhao Wei, Jingyi Zhao, Yong Mei Chen, Pengbo Zhang, Qiqing Zhang
Self-healing injectable hydrogels can be formulated as three-dimensional carriers for the treatment of neurological diseases with desirable advantages, such as avoiding the potential risks of cell loss during injection, protecting cells from the shearing force of injection. However, the demands for biocompatible self-healing injectable hydrogels to meet above requirements and to promote the differentiation of neural stem cells (NSCs) into neurons remain a challenge. Herein, we developed a biocompatible self-healing polysaccharide-based hydrogel system as a novel injectable carrier for the delivery of NSCs...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27890942/removal-of-phosphate-from-aqueous-solution-using-alginate-iron-iii-chloride-capsules-a-laboratory-study
#3
Hanna Siwek, Artur Bartkowiak, Małgorzata Włodarczyk, Katarzyna Sobecka
Binding phosphate at participation of alginate/FeCl3 capsules was studied with laboratory experiments. The hydrogel microcapsules were obtained with the dropping-in method, by gelation of sodium alginate water solution by iron (III) chloride solution. Phosphate adsorption characteristics were studied in a static batch system with respect to changes in contact time, initial phosphates concentration, pH of solution, and temperature. After 24 h of the tests, average 87.5% of phosphate ions were removed from the natural water solutions; after 48 h, an equilibrium was reached...
2016: Water, Air, and Soil Pollution
https://www.readbyqxmd.com/read/27886350/design-of-artificial-red-blood-cells-using-polymeric-hydrogel-microcapsules-hydrogel-stability-improvement-and-polymer-selection
#4
Wujie Zhang, Matthew J Bissen, Emily S Savela, Joshua N Clausen, Samantha J Fredricks, Xiaoru Guo, Zachary R Paquin, Ryan P Dohn, Ian J Pavelich, Alec L Polovchak, Michael J Wedemeyer, Brock E Shilling, Emily N Dufner, Anna C O'Donnell, Gerardo Rubio, Logan R Readnour, Tyler F Brown, Jung C Lee, Matey G Kaltchev, Junhong Chen, Charles S Tritt
PURPOSE: To improve the stability of pectin-oligochitosan hydrogel microcapsules under physiological conditions. METHODS: Two different approaches were examined: change of the cross-linker length and treatment of the hydrogel microcapsules with 150 Mm CaCl2. Replacement of pectin with alginate was also studied. RESULTS AND CONCLUSIONS: It was observed that the molecular weight of the cross-linker oligochiotsan had no significant improvement on microcapsule stability...
November 16, 2016: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/27885831/a-bioinspired-ultraporous-nanofiber-hydrogel-mimic-of-the-cartilage-extracellular-matrix
#5
Florian A Formica, Ece Öztürk, Samuel C Hess, Wendelin J Stark, Katharina Maniura-Weber, Markus Rottmar, Marcy Zenobi-Wong
A true biomimetic of the cartilage extracellular matrix (ECM) could greatly contribute to our ability to regenerate this tissue in a mechanically demanding, often inflamed environment. Articular cartilage is a composite tissue made of cells and fibrillar proteins embedded in a hydrophilic polymeric meshwork. Here, a polyanionic functionalized alginate is used to mimic the glycosaminoglycan component of the native ECM. To create the fibrillar component, cryoelectrospinning of poly(ε-caprolactone) on a -78 °C mandrel, subsequently treated by O2 plasma, is used to create a stable, ultraporous and hydrophillic nanofiber network...
November 25, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27869911/controlled-production-of-sub-millimeter-liquid-core-hydrogel-capsules-for-parallelized-3d-cell-culture
#6
Hugo Doméjean, Mathieu de la Motte Saint Pierre, Anette Funfak, Nicolas Atrux-Tallau, Kevin Alessandri, Pierre Nassoy, Jérôme Bibette, Nicolas Bremond
Liquid core capsules having a hydrogel membrane are becoming a versatile tool for three-dimensional culture of micro-organisms and mammalian cells. Making sub-millimeter capsules at a high rate, via the breakup of a compound jet in air, opens the way to high-throughput screening applications. However, control of the capsule size monodispersity, especially required for quantitative bioassays, was still lacking. Here, we report how the understanding of the underlying hydrodynamic instabilities that occur during the process can lead to calibrated core-shell bioreactors...
November 21, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27864999/a-synthetic-toolbox-for-the-in-situ-formation-of-functionalized-homo-and-heteropolysaccharide-based-hydrogel-libraries
#7
Nick Dibbert, Andreas Krause, Julio-Cesar Rios-Camacho, Ina Gruh, Andreas Kirschning, Gerald Dräger
A synthetic toolbox for the introduction of aldehydo and hydrazido groups into the polysaccharides hyaluronic acid, alginate, dextran, pullulan, glycogen, and carboxymethyl cellulose and their use for hydrogel formation is reported. Upon mixing differently functionalized polysaccharides derived from the same natural precursor, hydrazone cross-linking takes place, which results in formation of a hydrogel composed of one type of polysaccharide backbone. Likewise, hydrogels based on two different polysaccharide strands can be formed after mixing the corresponding aldehydo- and hydrazido-modified polysaccharides...
November 16, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27845225/on-the-demixing-of-hyaluronan-and-alginate-in-the-gel-state
#8
Francesca Scognamiglio, Andrea Travan, Michela Cok, Massimiliano Borgogna, Eleonora Marsich, Sergio Paoletti, Ivan Donati
The manuscript focuses on the demixing of hyaluronan and alginate in the hydrogel state. Binary solutions of the two polysaccharides have been treated with Ca(2+) as the alginate cross-linking ion and the radial distribution of the two components in the hydrogels was measured by means of (1)H NMR. These results revealed the presence of alginate-enriched and hyaluronan-enriched domains stemming from a polysaccharide demixing. The hydrogels were characterized by means of uniaxial compression and creep-compliance measurements which showed that the demixing increased the overall resistance of the hydrogel to stress...
November 11, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27842806/synthesis-of-dual-responsive-carbohydrate-polymer-based-ipn-microbeads-for-controlled-release-of-anti-hiv-drug
#9
S Eswaramma, K S V Krishna Rao
The present study aims at preparation of dual responsive interpenetrating polymer network hydrogel microbeads from sodium alginate and functionally modified guar gum. Guar gum was modified by graft copolymerization using N-vinylcaprolactam, the maximum % grafting 123.2, obtained at different optimized conditions. The graft copolymer was blended with sodium alginate to form hydrogel microbeads by emulsion crosslinking method using glutaraldehyde as crosslinker. Zidovudine, an anti-HIV drug was encapsulated with 68% encapsulation efficiency...
January 20, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27830559/microencapsulation-of-hepatocytes-and-mesenchymal-stem-cells-for-therapeutic-applications
#10
Raphael P H Meier, Elisa Montanari, Philippe Morel, Joël Pimenta, Henk-Jan Schuurman, Christine Wandrey, Sandrine Gerber-Lemaire, Redouan Mahou, Leo H Bühler
Encapsulated hepatocyte transplantation and encapsulated mesenchymal stem cell transplantation are newly developed potential treatments for acute and chronic liver diseases, respectively. Cells are microencapsulated in biocompatible semipermeable alginate-based hydrogels. Microspheres protect cells against antibodies and immune cells, while allowing nutrients, small/medium size proteins and drugs to diffuse inside and outside the polymer matrix. Microencapsulated cells are assessed in vitro and designed for experimental transplantation and for future clinical applications...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27826002/3d-culture-of-human-pluripotent-stem-cells-in-rgd-alginate-hydrogel-improves-retinal-tissue-development
#11
Nicola C Hunt, Dean Hallam, Ayesha Karimi, Carla B Mellough, Jinju Chen, David H W Steel, Majlinda Lako
: No treatments exist to effectively treat many retinal diseases. Retinal pigmented epithelium (RPE) and neural retina can be generated from human embryonic stem cells/induced pluripotent stem cells (hESCs/hiPSCs). The efficacy of current protocols is, however, limited. It was hypothesised that generation of laminated neural retina and/or RPE from hiPSCs/hESCs could be enhanced by 3D culture in hydrogels. hiPSC- and hESC-derived embryoid bodies (EBs) were encapsulated in 0.5% RGD-alginate; 1% RGD-alginate; hyaluronic acid (HA) or HA/gelatin hydrogels and maintained until day 45...
November 5, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27825531/preliminary-study-on-an-innovative-simple-mast-cell-based-electrochemical-method-for-detecting-foodborne-pathogenic-bacterial-quorum-signaling-molecules-n-acyl-homoserine-lactones
#12
Donglei Jiang, Dongdong Feng, Hui Jiang, Limin Yuan, Yin Yongqi, Xin Xu, Weiming Fang
This paper reports the a novel and simple mast cell-based electrochemical method for detecting of bacterial quorum signaling molecules, N-acylhomoserine lactones (AHLs), which can be utilized to preliminarily evaluate the toxicity of food-borne pathogenic bacteria. Rat basophilic leukemia (RBL-2H3) mast cells encapsulated in alginate/graphene oxide hydrogel were immobilized on a gold electrode, while mast cells as recognition elements were cultured in a 3D cell culture system. Electrochemical impedance spectroscopy (EIS) was utilized to record the cell impedance signal as-influenced by Pseudomonas aeruginosa quorum-sensing molecule, N-3-oxododecanoyl homoserine lactone (3OC12-HSL)...
September 28, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27810103/development-of-zirconia-nanoparticles-decorated-calcium-alginate-hydrogel-fibers-for-extraction-of-organophosphorous-pesticides-from-water-and-juice-samples-facile-synthesis-and-application-with-elimination-of-matrix-effects
#13
Maryam Zare, Zahra Ramezani, Nadereh Rahbar
In this research, novel zirconia nanoparticles-decorated calcium alginate hydrogel fibers (ZNCAHF) were synthesized through a simple, green procedure. ZNCAHF were used as an adsorbent in the micro-solid-phase extraction (MSPE) of methyl parathion (MP), fenitrothion (FT) and malathion (MT) as model pesticides prior to gas chromatography-mass spectroscopic detection (GC-MS). The composition and morphology of the prepared fiber were characterized by Fourier transform-infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), energy dispersive X-ray diffraction (EDX), and differential scanning calorimetry (DSC)...
October 29, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27805793/production-of-hollow-bacterial-cellulose-microspheres-using-microfluidics-to-form-an-injectable-porous-scaffold-for-wound-healing
#14
Jiaqing Yu, Tzu-Rung Huang, Zhen Han Lim, Rongcong Luo, Rupali Reddy Pasula, Lun-De Liao, Sierin Lim, Chia-Hung Chen
Bacterial cellulose (BC) is a biocompatible material with high purity and robust mechanical strength used to fabricate desirable scaffolds for 3D cell culture and wound healing. However, the chemical resistance of BC and its insolubility in the majority of solutions make it difficult to manipulate using standard chemical methods. In this study, a microfluidic process is developed to produce hollow BC microspheres with desirable internal structures and morphology. Microfluidics is used to generate a core-shell structured microparticle with an alginate core and agarose shell as a template to encapsulate Gluconacetobacter xylinus for long-term static culture...
November 2, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27798621/deterministic-encapsulation-of-single-cells-in-thin-tunable-microgels-for-niche-modelling-and-therapeutic-delivery
#15
Angelo S Mao, Jae-Won Shin, Stefanie Utech, Huanan Wang, Oktay Uzun, Weiwei Li, Madeline Cooper, Yuebi Hu, Liyuan Zhang, David A Weitz, David J Mooney
Existing techniques to encapsulate cells into microscale hydrogels generally yield high polymer-to-cell ratios and lack control over the hydrogel's mechanical properties. Here, we report a microfluidic-based method for encapsulating single cells in an approximately six-micrometre layer of alginate that increases the proportion of cell-containing microgels by a factor of ten, with encapsulation efficiencies over 90%. We show that in vitro cell viability was maintained over a three-day period, that the microgels are mechanically tractable, and that, for microscale cell assemblages of encapsulated marrow stromal cells cultured in microwells, osteogenic differentiation of encapsulated cells depends on gel stiffness and cell density...
October 31, 2016: Nature Materials
https://www.readbyqxmd.com/read/27796159/imaging-of-hydrogel-microsphere-structure-and-foreign-body-response-based-on-endogenous-x-ray-phase-contrast
#16
Alyssa A Appel, Veronica Ibarra, Sami I Somo, Jeffery C Larson, Alfred B Garson, Huifeng Guan, John Patrick McQuilling, Zhong Zhong, Mark A Anastasio, Emmanuel C Opara, Eric M Brey
Transplantation of functional islets encapsulated in stable biomaterials has the potential to cure Type I diabetes. However, the success of these materials requires the ability to quantitatively evaluate their stability. Imaging techniques that enable monitoring of biomaterial performance are critical to further development in the field. X-ray phase-contrast (XPC) imaging is an emerging class of X-ray techniques that have shown significant promise for imaging biomaterial and soft tissue structures. In this study, XPC imaging techniques are shown to enable three dimensional (3D) imaging and evaluation of islet volume, alginate hydrogel structure, and local soft tissue features ex vivo...
November 2016: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/27772727/a-scaffold-filter-model-for-studying-the-chondrogenic-differentiation-of-stem-cells-in-vitro
#17
Ling Zhang, Li Zheng, Hong S Fan, Xing D Zhang
This study was undertaken to explore the synergistic effect of scaffold materials and a cartilage-like environment on the chondrogenic differentiation of stem cells. Because stem cells encapsulated in a cartilage scaffold will be induced by scaffold molecules as well as permeable molecules from the surroundings, it is impossible to optimize a chondro-inducible scaffold without considering environmental sensitivity. How do we know if a designed scaffold will be sufficient prior to implantation? In this study, bone marrow mesenchymal stem cells (bMSCs) were seeded in various scaffolds, including collagen hydrogel, collage/sodium alginate hydrogel, collagen sponge and silk fibroin sponge...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27770895/effects-of-halloysite-nanotubes-on-physical-properties-and-cytocompatibility-of-alginate-composite-hydrogels
#18
Biao Huang, Mingxian Liu, Zheru Long, Yan Shen, Changren Zhou
Sodium alginate (SA)/halloysite nanotubes (HNTs) composite hydrogels were successfully prepared by solution blending and cross-linking with calcium ions. HNTs can improve the physical properties and cytocompatibility of composite hydrogels. The static and shear viscosity of SA/HNTs solution increase by the addition of HNTs. FTIR suggests the presence of hydrogen bond interactions between HNTs and SA. The crystal structure of HNTs is retained in the composites as showed by the X-ray diffraction result. A porous structure with pore size of 100-250μm is found in the hydrogels, which can provide a space for cell growth and migration...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27770893/covalently-antibacterial-alginate-chitosan-hydrogel-dressing-integrated-gelatin-microspheres-containing-tetracycline-hydrochloride-for-wound-healing
#19
Huinan Chen, Xiaodong Xing, Huaping Tan, Yang Jia, Tianle Zhou, Yong Chen, Zhonghua Ling, Xiaohong Hu
An antibacterial and biodegradable composite hydrogel dressing integrated with microspheres is developed for drug delivery and wound healing. The mechanism of gelation is attributed to the Schiff-base reaction between aldehyde and amino groups of oxidized alginate (OAlg) and carboxymethyl chitosan (CMCS). To enhance antibacterial and mechanical properties, tetracycline hydrochloride (TH) loaded gelatin microspheres (GMs) were fabricated by an emulsion cross-linking method, followed by integrating into the OAlg-CMCS hydrogel to produce a composite gel dressing...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27768085/extraction-of-structural-extracellular-polymeric-substances-from-aerobic-granular-sludge
#20
Simon Felz, Salah Al-Zuhairy, Olav Andreas Aarstad, Mark C M van Loosdrecht, Yue Mei Lin
To evaluate and develop methodologies for the extraction of gel-forming extracellular polymeric substances (EPS), EPS from aerobic granular sludge (AGS) was extracted using six different methods (centrifugation, sonication, ethylenediaminetetraacetic acid (EDTA), formamide with sodium hydroxide (NaOH), formaldehyde with NaOH and sodium carbonate (Na2CO3) with heat and constant mixing). AGS was collected from a pilot wastewater treatment reactor. The ionic gel-forming property of the extracted EPS of the six different extraction methods was tested with calcium ions (Ca(2+))...
September 26, 2016: Journal of Visualized Experiments: JoVE
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