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alginate hydrogel

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https://www.readbyqxmd.com/read/28544472/engineering-muscle-cell-alignment-through-3d-bioprinting
#1
Pamela Mozetic, Sara Maria Giannitelli, Manuele Gori, Marcella Trombetta, Alberto Rainer
Processing of hydrogels represents a main challenge for the prospective application of additive manufacturing (AM) to soft tissue engineering. Furthermore, direct manufacturing of tissue precursors with a cell density similar to native tissues has the potential to overcome the extensive in vitro culture required for conventional cell-seeded scaffolds seeking to fabricate constructs with tailored structural and functional properties. In this work, we present a simple AM methodology that exploits the thermoresponsive behavior of a block copolymer (Pluronic®) as a means to obtain good shape retention at physiological conditions and to induce cellular alignment...
May 22, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28541940/efficient-removal-of-cd-2-ion-from-water-by-calcium-alginate-hydrogel-filtration-membrane
#2
Ye Li, Kongyin Zhao, Wei Yang, Guanyi Chen, Xinxin Zhang, Yujie Zhao, Liang Liu, Min Chen
Calcium alginate (CaAlg) hydrogel filtration membrane was prepared using urea as pore-forming agent. The effects of preparation and operating conditions on the removal rate of Cd(2+) were researched. The removal mechanism of Cd(2+) and the anti-fouling property of CaAlg membrane were investigated. The removal rate of the CaAlg filtration membrane reached over 99.5% within 120 min when 20 mg/L Cd(2+) was used, and the flux was 15.5 L/m(2)h at 0.1 MPa when the thickness of the membrane was 0.28 ± 0.08 mm. However, the removal rate of Cd(2+) was below 10...
May 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28540461/quantitative-analysis-of-curcumin-loaded-alginate-nanocarriers-in-hydrogels-using-raman-and-attenuated-total-reflection-infrared-spectroscopy
#3
Lynda Miloudi, Franck Bonnier, Dominique Bertrand, Hugh J Byrne, Xavier Perse, Igor Chourpa, Emilie Munnier
Core-shell nanocarriers are increasingly being adapted in cosmetic and dermatological fields, aiming to provide an increased penetration of the active pharmaceutical or cosmetic ingredients (API and ACI) through the skin. In the final form, the nanocarriers (NC) are usually prepared in hydrogels, conferring desired viscous properties for topical application. Combined with the high chemical complexity of the encapsulating system itself, involving numerous ingredients to form a stable core and quantifying the NC and/or the encapsulated active without labor-intensive and destructive methods remains challenging...
May 25, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28539292/-gelatin-alginate-hydrogel-scaffolds-prepared-by-3d-bioprinting-promotes-cell-adhesion-and-proliferation-of-human-dental-pulp-cells-in-vitro
#4
Hai-Yue Yu, Dan-Dan Ma, Bu-Ling Wu
OBJECTIVE: To evaluate the cytotoxicity of gelatin/alginate hydrogel scaffolds prepared by 3D bioprinting in human dental pulp cells (HDPCs) and compare the cell adhesion and proliferation of the cells seeded in the biomaterial using two different methods. METHODS: HDPCs isolated by tissue block culture and enzyme digestion were cultured and passaged. Gelatin/alginate hydrogel scaffolds were printed using a bioplotter, and the cytotoxicity of the aqueous extracts of the scaffold material was tested in the third passage of HDPCs using cell counting kit-8...
May 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28537482/programmed-platelet-derived-growth-factor-%C3%AE-%C3%AE-and-bone-morphogenetic-protein-2-delivery-from-a-hybrid-calcium-phosphate-alginate-scaffold
#5
Emily A Bayer, Jahnelle Jordan, Riccardo Gottardi, Morgan Fedorchak, Prashant N Kumta, Steven Little
Bone tissue engineering requires the upregulation of several regenerative stages, including a critical early phase of angiogenesis. Previous studies have suggested that a sequential delivery of PDGF to BMP-2 could promote angiogenic tubule formation when delivered to in vitro co-cultures of human umbilical vein endothelial cells (HUVECs) and human mesenchymal stem cells (hMSCs). However, it was previously unclear that this PDGF to BMP-2 delivery schedule will result in cell migration into the scaffolding system and affect the later expression of bone markers...
May 24, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28530091/3d-bioprinting-of-highly-thixotropic-alginate-methylcellulose-hydrogel-with-strong-interface-bonding
#6
Huijun Li, Yu Jun Tan, Kah Fai Leong, Lin Li
A robust alginate/methylcellulose (Alg/MC) blend hydrogel, with a strategy to improve adhesion between printed layers, has been fabricated for the first time for 3D bioprinting. The optimized Alg/MC blend hydrogel exhibits highly thixotropic property, great extrudability and stackability. With treatment by a trisodium citrate (TSC) solution, the interfacial bonding between printed layers is significantly improved. The TSC solution acts as a chelating agent to remove the superficial calcium ions at each layer...
May 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28525313/a-tunable-three-dimensional-in-vitro-culture-model-of-growth-plate-cartilage-using-alginate-hydrogel-scaffolds
#7
Alek G Erickson, Taylor D Laughlin, Sarah M Romereim, Catherine N Sargus-Patino, Angela K Pannier, Andrew T Dudley
Defining the final size and geometry of engineered tissues through precise control of the scalar and vector components of tissue growth is a necessary benchmark for regenerative medicine, but it has proved to be a significant challenge for tissue engineers. The growth plate cartilage that promotes elongation of the long bones is a good model system for studying morphogenetic mechanisms because cartilage is composed of a single cell type, the chondrocyte; chondrocytes are readily maintained in culture; and growth trajectory is predominately in a single vector...
May 18, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28517237/development-of-an-alginate-hydrogel-to-deliver-aqueous-bait-for-pest-ant-management
#8
Jia-Wei Tay, Mark S Hoddle, Ashok Mulchandani, Dong-Hwan Choe
BACKGROUND: Insecticide sprays used for ant control cause environmental contamination. Liquid bait is a safe and effective alternative, but it requires bait stations to dispense the toxicant. We developed a biodegradable hydrogel to deliver liquid bait obviating the need for bait stations. RESULTS: Alginate hydrogel beads with preferred rigidity and maximum hydration in 25% sucrose solution were engineered by optimizing a crosslinking process. The moisture content of the substrate on which the beads were placed and the relative atmospheric humidity significantly influenced water loss dynamics of the hydrated hydrogel beads...
May 18, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28516893/design-of-electrohydrodynamic-sprayed-polyethylene-glycol-hydrogel-microspheres-for-cell-encapsulation
#9
Anisa S Qayyum, Era Jain, Grant Kolar, Yonghyun Kim, Scott A Sell, Silviya P Zustiak
Electrohydrodynamic spraying (EHS) has recently gained popularity for microencapsulation of cells for applications in cell delivery and tissue engineering. Some of the polymers compatible with EHS are alginate, chitosan, and other similar natural polymers, which are subject to ionotropic or physical gelation. It is desirable to further extend the use of the EHS technique beyond such polymers for wider biofabrication applications. Here, building upon our previous work of making PEG microspheres via EHS, we utilized the principles of EHS to fabricate cell-laden polyethylene glycol (PEG) hydrogel microspheres...
May 18, 2017: Biofabrication
https://www.readbyqxmd.com/read/28504157/biomacromolecular-based-ionic-covalent-hydrogels-for-cell-encapsulation-the-atelocollagen-oxidized-polysaccharides-couples
#10
Andreea Luca, Vasilica Maier, Stelian S Maier, Maria Butnaru, Maricel Danu, Constanta Ibanescu, Mariana Pinteala, Marcel Popa
Mixed crosslinked networks of ionic-covalent entanglement type were prepared starting from ternary mixtures of atelocollagen (aK; as fibrillary matrix generator), sodium hyaluronate (NaHyal; a microfibrillation assistant), and oxidized polysaccharides (OxPolys; as both cross-linkers and matrix fillers), and were tested as hydrogels for eukaryotic cell encapsulation. Either oxidized gellan (GellOx) or pullulan (PullOx) were used. An original procedure and optimal hydrogel recipes were developed to encapsulate fibroblasts and adipose-derived stem cells, while preserving their viability and proliferative ability during ex vivo temporarily storage...
August 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28504137/gelation-of-na-alginate-aqueous-solution-a-study-of-sodium-ion-dynamics-via-nmr-relaxometry
#11
Congxian Zhao, Chao Zhang, Hongliang Kang, Yanzhi Xia, Kunyan Sui, Ruigang Liu
Sodium alginate (SA) hydrogels have a wide range of applications including tissue engineering, drug delivery and formulations for preventing gastric reflux. The dynamics of sodium ions during the gelation process of SA solution is critical for clarification of the gelation procedure. In this work, nuclear magnetic resonance (NMR) relaxometry and pulsed-field-gradient (PFG) NMR diffusometry were used to investigate the dynamics of the sodium ions during the gelation of SA alginate. We find that sodium ions are in two different states with the addition of divalent calcium ions, corresponding to Ca(2+) crosslinked and un-crosslinked regions in the hydrogels...
August 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28501720/characterization-and-restoration-of-degenerated-ivd-function-with-an-injectable-in-situ-gelling-alginate-hydrogel-an-in-vitro-and-ex-vivo-study
#12
Emily A Growney Kalaf, Meghana Pendyala, J Gary Bledsoe, Scott A Sell
Intervertebral disc (IVD) degeneration is a naturally, irreparable process that causes loss in IVD hydration, cellularity, and, mechanical stability. Invasive surgical attempts to ease back pain and, radiculopathy have shown to cause increased degeneration along the rest, of the spine. Due to its highly tunable mechanical and degradation, properties, alginate is a viable option for a less-invasive injectable, repair for IVD degeneration. This study centers on the characterization, of in situ gelling alginate and subsequent injection into enzymatically, degraded motion segments...
May 7, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28501603/polyelectrolyte-complexes-based-on-alginate-tanfloc-optimization-characterization-and-medical-application
#13
Débora P Facchi, Ana C Lima, Jean H de Oliveira, Danielle Lazarin-Bidóia, Celso V Nakamura, Edmilson A Canesin, Elton G Bonafé, Johny P Monteiro, Jesuí V Visentainer, Edvani C Muniz, Alessandro F Martins
Hydrogels based on alginate and tanfloc (a cationic biopolymer obtained from natural condensed tannins) were successfully prepared. Tanfloc (TN) presents high aqueous solubility at pHs lower than 10; it contains substituted amino sites and molar weight of ca. 600,000gmol(-1). A factorial design (2(2)) was used to optimize the yield of alginate/tanfloc polyelectrolyte complexes (PECs). Dialysis recovered the overplus of alginate (AG) no complexed with TN. These materials were characterized by thermal analyses (TGA/DTG and DSC), zeta potential, and FTIR, while SEM technique depicted a rough surface on AG/TN complex, containing non-homogeneous pores...
May 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28489424/a-novel-ph-responsive-hydrogel-based-on-calcium-alginate-engineered-by-the-previous-formation-of-polyelectrolyte-complexes-pecs-intended-to-vaginal-administration
#14
Natália Noronha Ferreira, Taciane Alvarenga Perez, Liliane Neves Pedreiro, Fabíola Garavello Prezotti, Fernanda Isadora Boni, Valéria Maria de Oliveira Cardoso, Tiago Venâncio, Maria Palmira Daflon Gremião
This work aimed to develop a calcium alginate hydrogel as a pH responsive delivery system for polymyxin B (PMX) sustained-release through the vaginal route. Two samples of sodium alginate from different suppliers were characterized. The molecular weight and M/G ratio determined were, approximately, 107 KDa and 1.93 for alginate_S and 32 KDa and 1.36 for alginate_V. Polymer rheological investigations were further performed through the preparation of hydrogels. Alginate_V was selected for subsequent incorporation of PMX due to the acquisition of pseudoplastic viscous system able to acquiring a differential structure in simulated vaginal microenvironment (pH 4...
May 10, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28483511/collagen-alginate-microspheres-as-a-3d-culture-system-for-mouse-embryonic-stem-cells-differentiation-to-primordial-germ-cells
#15
Vahid Mansouri, Mohammad Salehi, Mir Davood Omrani, Zahra Niknam, Abdolreza Ardeshirylajimi
Germ cells differentiation of stem cells will aid treatment of adults with infertility. Biopolymers utilization provided synthetic extracellular matrix (ECM) and desired attributes in in vitro to improve conditions for stem cells attachment, proliferation and differentiation. Mixture of alginate as a biocompatible hydrogel, with collagen IV, could establish an in vitro 3 dimensional (3D) culture model. The objective of this study was investigation of the mouse ESCs differentiation capacity to putative primordial germ cells (PGCs) in the alginate and alginate-collagen IV microspheres (CAM)...
May 5, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28482472/caffeine-a-novel-green-precursor-for-synthesis-of-magnetic-cofe2o4-nanoparticles-and-ph-sensitive-magnetic-alginate-beads-for-drug-delivery
#16
Mahnaz Amiri, Masoud Salavati-Niasari, Abbas Pardakhty, Meysam Ahmadi, Ahmad Akbari
Hydrogel beads are promising delivery systems for encapsulation and release of drugs due to the mild process of their fabrication from biopolymers. Magnetic CoFe2O4 nanoparticles (MCFO, 9.72nm in diameter) were synthesized via a co-precipitation method using caffeine as a new environmentally friendly material in order to alkalinize the medium. Drug-targeting Magnetic beads based on CoFe2O4 nanoparticles, sodium alginate and chlorpheniramine maleate (CPAM) were synthesized in the presence of Ca(2+) ions to obtain ionic cross-linked magnetic hydrogel beads...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28482469/enhanced-proliferation-of-human-bone-marrow-derived-mesenchymal-stem-cells-on-tough-hydrogel-substrates
#17
Deepti Rana, Murugan Ramalingam
Stem cell plays a significant role in tissue engineering and regenerative medicine. However, one of the major limitations in translation of stem cell technologies for clinical applications is limited cell survival and growth upon implantation. To address this limitation, authors have made an attempt to design polyacrylamide/alginate (PAAm/Algi) based tough hydrogel substrates and studied their impact on the survival and proliferation of human bone marrow-derived mesenchymal stem cells (hBMSCs). The PAAm/Algi hydrogel substrates have been prepared by initiator-induced free radical polymerization with mechanical properties quite similar to human soft tissues...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28481253/drug-loadable-calcium-alginate-hydrogel-system-for-use-in-oral-bone-tissue-repair
#18
Luyuan Chen, Renze Shen, Satoshi Komasa, Yanxiang Xue, Bingyu Jin, Yepo Hou, Joji Okazaki, Jie Gao
This study developed a drug-loadable hydrogel system with high plasticity and favorable biological properties to enhance oral bone tissue regeneration. Hydrogels of different calcium alginate concentrations were prepared. Their swelling ratio, degradation time, and bovine serum albumin (BSA) release rate were measured. Human periodontal ligament cells (hPDLCs) and bone marrow stromal cells (BMSCs) were cultured with both calcium alginate hydrogels and polylactic acid (PLA), and then we examined the proliferation of cells...
May 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28469183/coaxial-3d-bioprinting-of-self-assembled-multicellular-heterogeneous-tumor-fibers
#19
Xingliang Dai, Libiao Liu, Jia Ouyang, Xinda Li, Xinzhi Zhang, Qing Lan, Tao Xu
Three-dimensional (3D) bioprinting of living structures with cell-laden biomaterials has been achieved in vitro, however, some cell-cell interactions are limited by the existing hydrogel. To better mimic tumor microenvironment, self-assembled multicellular heterogeneous brain tumor fibers have been fabricated by a custom-made coaxial extrusion 3D bioprinting system, with high viability, proliferative activity and efficient tumor-stromal interactions. Therein, in order to further verify the sufficient interactions between tumor cells and stroma MSCs, CRE-LOXP switch gene system which contained GSCs transfected with "LOXP-STOP-LOXP-RFP" genes and MSCs transfected with "CRE recombinase" gene was used...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28467835/self-supporting-nanoclay-as-internal-scaffold-material-for-direct-printing-of-soft-hydrogel-composite-structures-in-air
#20
Yifei Jin, Chengcheng Liu, Wenxuan Chai, Ashley Compaan, Yong Huang
Three dimensional (3D) bioprinting technology enables the freeform fabrication of complex constructs from various hydrogels and is receiving increasing attention in tissue engineering. The objective of this study is to develop a novel self-supporting direct hydrogel printing approach to extrude complex 3D hydrogel composite structures in air without the help of a support bath. Laponite, a member of the smectite mineral family, is investigated to serve as an internal scaffold material for the direct printing of hydrogel composite structures in air...
May 11, 2017: ACS Applied Materials & Interfaces
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