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Liver and elastography and measurement number

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https://www.readbyqxmd.com/read/28914407/association-of-fetuin-b-with-markers-of-liver-fibrosis-in-nonalcoholic-fatty-liver-disease
#1
Thomas Ebert, Nicolas Linder, Alexander Schaudinn, Harald Busse, Joachim Berger, Ralf Lichtinghagen, Volker Keim, Johannes Wiegand, Thomas Karlas
OBJECTIVE: The liver-derived plasma protein fetuin B is associated with nonalcoholic fatty liver disease (NAFLD) and impaired glucose homeostasis in mice. However, its association with non-invasive ultrasound- and magnetic resonance (MR)-based markers of liver fibrosis and steatosis, the enhanced liver fibrosis (ELF) score, liver biopsy, as well as rs738409 in PNPLA3, has not been elucidated in NAFLD, so far. DESIGN AND METHODS: The association of circulating fetuin B and transient elastography (TE), controlled attenuation parameter (CAP), (1)H-MR-spectroscopy, the ELF score, liver biopsy, as well as risk alleles in rs738409 in PNPLA3, was studied in 101 NAFLD patients as compared to 15 healthy controls...
September 15, 2017: Endocrine
https://www.readbyqxmd.com/read/28853196/a-new-screening-strategy-for-varices-by-liver-and-spleen-stiffness-measurement-lssm-in-cirrhotic-patients-a-randomized-trial
#2
Grace Lai-Hung Wong, Raymond Kwok, Aric Josun Hui, Yee-Kit Tse, Kai-Tin Ho, Angeline Oi-Shan Lo, Kelvin Long-Yan Lam, Heyson Chi-Hey Chan, Rashid Abdul Lui, Kenneth Hon-Da Au, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong
BACKGROUND: Variceal bleeding is a common and life-threatening complication in patients with liver cirrhosis. Screening with upper endoscopy is recommended but is uncomfortable to patients. Non-invasive assessment with transient elastography for liver/spleen stiffness measurement (LSM and SSM) is accurate in detecting varices. AIMS: To test the hypothesis that a new screening strategy for varices guided by LSM/SSM results (LSSM-guided) is non-inferior to universal endoscopic screening in detecting clinically significant varices in patients with cirrhosis...
August 29, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28658094/multimorbidity-and-polypharmacy-in-diabetic-patients-with-nafld-implications-for-disease-severity-and-management
#3
Preya Janubhai Patel, Kelly Lee Hayward, Rathiga Rudra, Leigh Ula Horsfall, Fabrina Hossain, Suzanne Williams, Tracey Johnson, Nigel Neil Brown, Nivene Saad, Andrew Donald Clouston, Katherine Anne Stuart, Patricia Casarolli Valery, Katharine Margaret Irvine, Anthony William Russell, Elizabeth Ellen Powell
An observational study describing the number and type of chronic conditions and medications taken by diabetic patients with NAFLD and identifying characteristics that may impact liver disease severity or clinical management.Adults with type 2 diabetes have a high prevalence of nonalcoholic fatty liver disease (NAFLD) and increased risk of developing advanced liver disease. Appropriate management should consider the characteristics of the diabetic NAFLD population, as comorbid conditions and medications may increase the complexity of treatment strategies...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28634626/hepatic-shear-wave-elastography-in-children-under-free-breathing-and-breath-hold-conditions
#4
Caroline Jung, Michael Groth, Kay Uwe Petersen, Anna Hammel, Florian Brinkert, Enke Grabhorn, Sören Alexander Weidemann, Jasmin Busch, Gerhard Adam, Jochen Herrmann
OBJECTIVES: To compare hepatic 2D shear wave elastography (2D SWE) in children between free-breathing and breath-hold conditions, in terms of measurement agreement and time expenditure. METHODS: A cohort of 57 children (12.7±4.3 years) who underwent standardized 2D SWE between May and October 2015 were retrospectively evaluated. Liver elastograms were obtained under free-breathing and breath-hold conditions and time expenditure was measured. Median stiffness, interquartile range (IQR), and IQR/median ratio were calculated based on 12, six, and three elastograms...
June 20, 2017: European Radiology
https://www.readbyqxmd.com/read/28578837/coffee-and-herbal-tea-consumption-is-associated-with-lower-liver-stiffness-in-the-general-population-the-rotterdam-study
#5
Louise J M Alferink, Juliana Fittipaldi, Jessica C Kiefte-de Jong, Pavel Taimr, Bettina E Hansen, Herold J Metselaar, Josje D Schoufour, M Arfan Ikram, Harry L A Janssen, Oscar H Franco, Sarwa Darwish Murad
BACKGROUND & AIMS: Coffee and tea have been proposed to limit the progression of liver fibrosis in established liver disease, but it is unknown if this is also true for subclinical fibrosis. We therefore aimed to evaluate whether coffee and tea consumption are associated with liver stiffness in the general population. METHODS: The Rotterdam Study is an ongoing prospective population-based cohort. We included participants who underwent transient elastography, ultrasound and completed a food frequency questionnaire...
May 21, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28561276/intestinal-microbiota-in-patients-with-chronic-hepatitis-c-with-and-without-liver-cirrhosis-compared-to-healthy-controls
#6
Benjamin Heidrich, Marius Vital, Iris Plumeier, Nico Döscher, Silke Kahl, Janina Kirschner, Szilvia Ziegert, Philipp Solbach, Henrike Lenzen, Andrej Potthoff, Michael Peter Manns, Heiner Wedemeyer, Dietmar Helmut Pieper
BACKGROUND AND AIMS: The importance of the intestinal microbiota for the onset and clinical course of many diseases, including liver diseases like non-alcoholic steatohepatitis and cirrhosis, is increasingly recognized. However, the role of intestinal microbiota in chronic HCV infection remains unclear. METHODS: In a cross sectional approach the intestinal microbiota of 95 patients chronically infected with HCV (n=57 without cirrhosis [NO-CIR]; n=38 with cirrhosis [CIR]) and 50 healthy controls (HC) without documented liver diseases was analysed...
May 31, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28480218/magnetic-resonance-elastography-shear-wave-velocity-correlates-with-liver-fibrosis-and-hepatic-venous-pressure-gradient-in-adults-with-advanced-liver-disease
#7
Ahmed M Gharib, Ma Ai Thanda Han, Eric G Meissner, David E Kleiner, Xiongce Zhao, Mary McLaughlin, Lindsay Matthews, Bisharah Rizvi, Khaled Z Abd-Elmoniem, Ralph Sinkus, Elliot Levy, Christopher Koh, Robert P Myers, G Mani Subramanian, Shyam Kottilil, Theo Heller, Joseph A Kovacs, Caryn G Morse
Background. Portal hypertension, an elevation in the hepatic venous pressure gradient (HVPG), can be used to monitor disease progression and response to therapy in cirrhosis. Since obtaining HVPG measurements is invasive, reliable noninvasive methods of assessing portal hypertension are needed. Methods. Noninvasive markers of fibrosis, including magnetic resonance elastography (MRE) shear wave velocity, were correlated with histologic fibrosis and HVPG measurements in hepatitis C (HCV) and/or HIV-infected patients with advanced liver disease enrolled in a clinical trial of treatment with simtuzumab, an anti-LOXL2 antibody...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28474275/comparison-of-mono-and-bipolar-radiofrequency-ablation-in-benign-thyroid-disease
#8
Yücel Korkusuz, Alexander Mader, Daniel Gröner, Shadi Ahmad, Oscar Maximilian Mader, Frank Grünwald, Christian Happel
PURPOSE: Radiofrequency ablation (RFA) is an approved minimal invasive method for the treatment of benign thyroid nodules. Several experimental, mainly ex vivo animal studies have compared the effectiveness of different RFA procedures in liver tissue. The aim of this retrospective clinical study was to evaluate the difference between monopolar and bipolar RFA in thyroid tissue considering thyroid volume reduction, patient discomfort and ultrasound evaluation. METHODS: Eighteen patients with symptomatic complex benign thyroid nodules were treated in a single RFA session...
May 4, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28361299/invasive-and-non-invasive-assessment-of-portal-hypertension
#9
REVIEW
Jonathan Chung-Fai Leung, Thomson Chi-Wang Loong, James Pang, Jeremy Lok Wei, Vincent Wai-Sun Wong
Portal hypertension is the central driver of complications in patients with chronic liver diseases and cirrhosis. The diagnosis of portal hypertension has important prognostic and clinical implications. In particular, screening for varices in patients with portal hypertension can effectively reduce the morbidity and mortality of variceal bleeding. In this article, we review the invasive and non-invasive methods to assess portal hypertension. Hepatic venous pressure gradient remains the gold standard to measure portal pressure but is invasive and seldom performed outside expert centers and research settings...
March 30, 2017: Hepatology International
https://www.readbyqxmd.com/read/28359007/physical-comorbidities-of-post-traumatic-stress-disorder-in-australian-vietnam-war-veterans
#10
Sarah C McLeay, Wendy M Harvey, Madeline Nm Romaniuk, Darrell Hg Crawford, David M Colquhoun, Ross McD Young, Miriam Dwyer, John M Gibson, Robyn A O'Sullivan, Graham Cooksley, Christopher R Strakosch, Rachel M Thomson, Joanne Voisey, Bruce R Lawford
OBJECTIVE: To determine whether the prevalence of physical comorbidities in Australian Vietnam War veterans with post-traumatic stress disorder (PTSD) is higher than in trauma-exposed veterans without PTSD. DESIGN, SETTING AND PARTICIPANTS: Cross-sectional analysis of the health status (based on self-reported and objective clinical assessments) of 298 Australian Vietnam War veterans enrolled by the Gallipoli Medical Research Institute (Brisbane) during February 2014 - July 2015, of whom 108 were confirmed as having had PTSD and 106 served as trauma-exposed control participants...
April 3, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28352941/easl-easd-easo-clinical-practice-guidelines-for-the-management-of-non-alcoholic-fatty-liver-disease-in-severely-obese-people-do-they-lead-to-over-referral
#11
Emilie Blond, Emmanuel Disse, Charlotte Cuerq, Jocelyne Drai, Pierre-Jean Valette, Martine Laville, Charles Thivolet, Chantal Simon, Cyrielle Caussy
AIMS/HYPOTHESIS: We aimed to assess the application of the recent European Association for the Study of the Liver (EASL)-European Association for the Study of Diabetes (EASD)-European Association for the Study of Obesity (EASO) clinical practice guidelines for the management of non-alcoholic fatty liver disease (NAFLD) in severely obese individuals in routine clinical practice. METHODS: We performed a single-centre retrospective observational study of 385 patients referred for severe obesity (BMI ≥ 35 kg/m(2)) to our Endocrinology, Diabetes and Nutrition department, between 1 November 2014 and 31 December 2015...
July 2017: Diabetologia
https://www.readbyqxmd.com/read/28295587/validation-of-non-invasive-methods-to-predict-the-presence-of-gastroesophageal-varices-in-a-cohort-of-patients-with-compensated-advanced-chronic-liver-disease
#12
Elba Llop, Marta Lopez, Juan de la Revilla, Natalia Fernandez, Maria Trapero, Marta Hernandez, Carlos Fernandez, Fernando Pons, Jose Luis Martinez, Jose Luis Calleja
INTRODUCTION: The aim was to validate non-invasive methods to predict the presence of gastroesophageal varices (GEV) in patients with suspected compensated advanced chronic liver disease (cACLD). METHODS: We retrospectively reviewed clinical and radiological data collected prospectively between September 2013 and September 2015. We reviewed 442 consecutive patients with suspected cACLD measured by transient elastography (TE) and a gastroscopy. We evaluated platelets, spleen diameter, TE, LSPS (liver stiffness x spleen size /platelets), variceal risk index (VRI), Baveno VI strategy and Augustin algorithm...
March 11, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28118179/two-dimensional-shear-wave-elastography-a-new-method-comparable-to-acoustic-radiation-force-impulse-imaging
#13
Barbara Schellhaas, Deike Strobel, Dane Wildner, Ruediger S Goertz, Markus F Neurath, Lukas Pfeifer
OBJECTIVES: Two-dimensional shear-wave elastography (2D-SWE) is an ultrasound-based technique for the noninvasive assessment of tissue stiffness. In contrast to the well-established point-shear-wave elastography (pSWE) method acoustic radiation force impulse imaging, there is little evidence on the performance and usefulness of 2D-SWE in the assessment of liver stiffness. Thus, the aim of our study was to compare 2D-SWE versus pSWE. MATERIALS AND METHODS: 2D-SWE and pSWE were performed in 20 cirrhotic patients, 20 healthy individuals and an elasticity phantom...
June 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28048591/tu-h-206-09-acceptance-testing-of-ultrasound-systems-for-shear-wave-elastography-measurements
#14
Z Long, D Tradup, P Song, S Stekel, S Chen, N Hangiandreou
PURPOSE: Acceptance testing of shear wave elastography on ten ultrasound systems is reported. Furthermore, variations in testing procedures related to coupling medium, number of operators, and phantom homogeneity were investigated. METHODS: Shear wave speed measurements were made on ten systems (GE LOGIQ E9 XDclear 2.0 ultrasound scanner with C1-6 and 9L transducers). Measurements were acquired using the CIRS Model 039 shear wave liver fibrosis phantoms ("soft" and "hard" phantoms, with stiffness of ∼3...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27887644/copenhagen-comorbidity-in-hiv-infection-cocomo-study-a-study-protocol-for-a-longitudinal-non-interventional-assessment-of-non-aids-comorbidity-in-hiv-infection-in-denmark
#15
Andreas Ronit, Judith Haissman, Ditte Marie Kirkegaard-Klitbo, Thomas Skårup Kristensen, Anne-Mette Lebech, Thomas Benfield, Jan Gerstoft, Henrik Ullum, Lars Køber, Andreas Kjær, Klaus Kofoed, Jørgen Vestbo, Børge Nordestgaard, Jens Lundgren, Susanne Dam Nielsen
BACKGROUND: Modern combination antiretroviral therapy (cART) has improved survival for people living with HIV (PLWHIV). Non-AIDS comorbidities have replaced opportunistic infections as leading causes of mortality and morbidity, and are becoming a key health concern as this population continues to age. The aim of this study is to estimate the prevalence and incidence of non-AIDS comorbidity among PLWHIV in Denmark in the cART era and to determine risk factors contributing to the pathogenesis...
November 26, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27822656/k-space-data-processing-for-magnetic-resonance-elastography-mre
#16
Nadège Corbin, Elodie Breton, Michel de Mathelin, Jonathan Vappou
OBJECTIVE: Magnetic resonance elastography (MRE) requires substantial data processing based on phase image reconstruction, wave enhancement, and inverse problem solving. The objective of this study is to propose a new, fast MRE method based on MR raw data processing, particularly adapted to applications requiring fast MRE measurement or high elastogram update rate. MATERIALS AND METHODS: The proposed method allows measuring tissue elasticity directly from raw data without prior phase image reconstruction and without phase unwrapping...
April 2017: Magma
https://www.readbyqxmd.com/read/27391646/liver-elasticity-measurement-before-and-after-biliary-drainage-in-patients-with-obstructive-jaundice-a-prospective-cohort-studya-prospective-cohort-study
#17
Kimitoshi Kubo, Hiroshi Kawakami, Masaki Kuwatani, Mutsumi Nishida, Kazumichi Kawakubo, Shuhei Kawahata, Yoko Taya, Yoshimasa Kubota, Toraji Amano, Hiroki Shirato, Naoya Sakamoto
BACKGROUND: Obstructive jaundice has been reported to influence liver elasticity, independent of liver fibrosis. The aim of our prospective study was to evaluate the changes in liver elasticity, before and after biliary drainage, in patients with obstructive jaundice, and to evaluate the correlation between elasticity measures and serum markers of liver fibrosis. METHODS: This is a prospective cohort study of 20 patients with obstructive jaundice. Liver elasticity was assessed by Transient Elastography (TE) and Virtual Touch™ Quantification (VTQ)...
July 8, 2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27324703/factors-associated-with-significant-liver-steatosis-and-fibrosis-as-assessed-by-transient-elastography-in-patients-with-one-or-more-components-of-the-metabolic-syndrome
#18
Ivana Mikolasevic, Sandra Milic, Lidija Orlic, Davor Stimac, Neven Franjic, Giovanni Targher
BACKGROUND/AIMS: We examined the relationship between controlled attenuation parameter (CAP) and liver stiffness measurements (LSM), as assessed by transient elastography (TE), and different clinical and biochemical parameters in patients with one or more components of the metabolic syndrome (MetS). The hypothesis of the study was that LSM and CAP values correlate with the number of MetS components. METHODS: In this cross-sectional study a total of 648 consecutive patients were recruited during the years 2013-2015...
September 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27239647/the-influence-of-acute-physical-effort-on-liver-stiffness-estimation-using-virtual-touch-quantification-vtq-preliminary-results
#19
Mariana M Gersak, Erich Sorantin, Jana Windhaber, Sorin M Dudea, Michael Riccabona
AIM: Food intake and acutely decompensated cardiac failure may impair liver stiffness estimations, mainly because these methods are influenced by liver blood flow variation encountered in these conditions. It is well known that also during physical effort liver blood flow changes, due to the redistribution of blood flow mainly to the skeletal muscles. The aim of this study is to assess the change of liver shear- wave velocities immediately after cessation of an acute physical effort. A secondary aim was to find the proper timing for accurate liver stiffness estimation after physical exhaustion...
June 2016: Medical Ultrasonography
https://www.readbyqxmd.com/read/27170387/novel-aspects-in-the-management-of-cholestatic-liver-diseases
#20
Olivier Chazouillères
BACKGROUND: There is a great need for risk stratification in patients with chronic cholestatic diseases in order to allow for more personalized care and adapted management as well as for well-designed therapeutic trials. Novel tools for monitoring primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) patients have been recently proposed. In addition, major insight has been gained into bile acid (BA) physiology during the last decade including the role of BAs as metabolic modulators and the gut-liver axis...
2016: Digestive Diseases
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