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Liver and elastography and measurement number

Nazarii Kobyliak, Ludovico Abenavoli, Galyna Mykhalchyshyn, Liudmyla Kononenko, Luigi Boccuto, Dmytro Kyriienko, Oleg Dynnyk
BACKGROUND: Probiotics have a beneficial effect on nonalcoholic fatty liver disease (NAFLD) in animal models. Randomized placebo-controlled trials (RCTs) in NAFLD are still lacking in humans despite a large number of data from animal research. AIM: We performed a double-blind single center RCT of live multi-strain probiotic vs. placebo in type 2 diabetes patients with NAFLD. METHODS: A total of 58 patients met the criteria for inclusion. They were randomly assigned to receive the multi-probiotic "Symbiter" (concentrated biomass of 14 probiotic bacteria genera Bifidobacterium, Lactobacillus, Lactococcus, Propionibacterium) or placebo for 8-weeks administered as a sachet formulation in double-blind treatment...
March 2018: Journal of Gastrointestinal and Liver Diseases: JGLD
Cheng Fang, Ounali S Jaffer, Gibran T Yusuf, Eleni Konstantatou, Daniel J Quinlan, Kosh Agarwal, Alberto Quaglia, Paul S Sidhu
Purpose To identify the minimum number of measurements required for the noninvasive assessment of liver fibrosis by using point shear-wave elastography (pSWE) and determine whether the use of a reliability indicator such as interquartile range [IQR]-to-median ratio will affect diagnostic performance. Materials and Methods Ten liver shear-wave velocity (SWV) measurements by pSWE were obtained in 232 participants. Interclass correlation coefficients (ICC) between the median of the first two through the first nine measurements and all 10 measurements were calculated; the minimum number of measurements with ICC greater than 0...
March 6, 2018: Radiology
Hyun Joo Shin, Myung-Joon Kim, Choon-Sik Yoon, Kwanseop Lee, Kwan Sik Lee, Jong-Chul Park, Mi-Jung Lee, Haesung Yoon
AIMS: To evaluate the differences between shear wave velocities (SWVs) measured with ultrasound elastography during the continuous motion using liver fibrosis phantoms. MATERIALS AND METHODS: Elasticities were measured with convex and linear transducers of supersonic shear wave imaging (SSI) and acoustic radiation force impulse imaging (ARFI) using liver elasticity phantoms (3.0 and 16.9 kPa) at depths of 2, 3, 4, and 5 cm. Motion velocities were 30 and 60 rpm with the phantoms in an upright position on the Orbital shaker...
February 4, 2018: Medical Ultrasonography
Grace Lai-Hung Wong
Non-invasive assessment of liver fibrosis has been one of the most rapidly advancing fields in hepatology in the last decade. Progressive liver fibrosis results in cirrhosis, hepatocellular carcinoma (HCC) and various liver-related complications in essentially all chronic liver diseases. Assessment of liver fibrosis allows clinicians to determine the prognosis, need of treatment, disease progression and response to treatment in patients with chronic liver disease. Liver biopsy has been the gold standard in last few decades and most adopted diagnostic tool in clinical trials...
January 30, 2018: Journal of Gastroenterology and Hepatology
Tiziana Vinciguerra, Andrea Brunati, Ezio David, Filomena Longo, Michele Pinon, Fulvio Ricceri, Luisa Castellino, Antonio Piga, Maria Teresa Giraudo, Francesco Tandoi, Fabio Cisarò, Dominic Dell Olio, Giuseppe Isolato, Renato Romagnoli, Mauro Salizzoni, Pier Luigi Calvo
As graft survival in pediatric LT is often affected by progressive fibrosis, numerous centers carry out protocol liver biopsies. Follow-up biopsy protocols differ from center to center, but all biopsies are progressively spaced out, as time from transplant increases. Therefore, there is a need for non-invasive techniques to evaluate graft fibrosis progression in those children who have no clinical or serological signs of liver damage. Indirect markers, such as the APRI, should be relied on with caution because their sensitivity in predicting fibrosis can be strongly influenced by the etiology of liver disease, severity of fibrosis, and patient age...
January 25, 2018: Pediatric Transplantation
Carolina Amador Carrascal, Shigao Chen, Matthew W Urban, James F Greenleaf
Ultrasound shear wave elastography is a promising noninvasive, low cost, and clinically viable tool for liver fibrosis staging. Current shear wave imaging technologies on clinical ultrasound scanners ignore shear wave dispersion and use a single group velocity measured over the shear wave bandwidth to estimate tissue elasticity. The center frequency and bandwidth of shear waves induced by acoustic radiation force depend on the ultrasound push beam (push duration, -number, etc.) and the viscoelasticity of the medium, and therefore are different across scanners from different vendors...
January 2018: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Nicolas Mottet, Sébastien Aubry, Chrystelle Vidal, Guillaume Boiteux, Jean-Patrick Metz, Didier Riethmuller, Lionel Pazart, Rajeev Ramanah
INTRODUCTION: 2-D ultrasound shear wave elastography (SWE) could be considered as a new noninvasive tool for monitoring fetal lung development based on evaluation of mechanical properties during pregnancy. Interesting results are available concerning the use of SWE on developing organs, especially on premature infants and animal models. The main objective in this study is to evaluate the feasibility of 2-D SWE in human fetal lungs between 24 and 34 weeks of gestation (WG). The secondary objective is to modellise fetal lung-to-liver elastography ratio (LLE ratio) and to assess variations between normal lung and lung surfactant-enriched after a corticosteroids course indicated for a threatened preterm labour (TPL)...
December 26, 2017: BMJ Open
D J Harman, S D Ryder, M W James, E A Wilkes, T R Card, G P Aithal, I N Guha
BACKGROUND: Rising cirrhosis incidence and mortality in the United Kingdom has been attributed predominantly to excess alcohol consumption. However, metabolic risk factors such as Type 2 diabetes and obesity may also be important. AIM: To screen at-risk individuals in general practice for undetected cirrhosis using transient elastography and study the risk factors underlying these cases. METHODS: The study was undertaken in 4 general practices (adult patient population 20 868) between February 2012 and September 2014...
February 2018: Alimentary Pharmacology & Therapeutics
William N Evans, Ruben J Acherman, Michael L Ciccolo, Sergio A Carrillo, Alvaro Galindo, Abraham Rothman, Gary A Mayman, Elizabeth A Adams, Leigh C Reardon, Brody J Winn, Noel S Yumiaco, Lesley Shimuizu, Yoko Inanaga, Rowena J Deleon, Humberto Restrepo
OBJECTIVE: We hypothesized that clinic-based, hepatic-ultrasound, elastography measurements, either alone or in combination with other noninvasive variables, might correlate with liver-biopsy fibrosis scores in patients post-Fontan. METHODS: Between March 2012 and February 2017, we identified patients post-Fontan that underwent elective cardiac catheterization and simultaneous transvenous hepatic biopsy. From this group, we selected patients that met inclusion criteria for liver-ultrasound, shear-wave elastography...
January 2018: Congenital Heart Disease
Eun Kyoung Hong, Young Hun Choi, Jung-Eun Cheon, Woo Sun Kim, In-One Kim, Sun Young Kang
Purpose: The purpose of this study was to evaluate the usefulness of the stability index (SI) in liver stiffness measurements using shear wave elastography (SWE) in children. Methods: A total of 29 children and young adults (mean age, 16.1 years; range, 8 to 28 years; 11 boys and 18 girls) who underwent liver stiffness measurements using SWE under free-breathing and breath-holding conditions were included in our study. Ten SWE measurements were acquired in each of four groups: free-breathing and breath-holding, and with and without using the SI...
August 19, 2017: Ultrasonography
Hye Won Lee, Kwang Joon Kim, Kyu Sik Jung, Young Eun Chon, Ji Hye Huh, Kyeong Hye Park, Jae Bock Chung, Chang Oh Kim, Kwang-Hyub Han, Jun Yong Park
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is closely related with obesity. However, obese subjects, generally represented by high BMI, do not always develop NAFLD. A number of possible causes of NAFLD have been studied, but the exact mechanism has not yet been elucidated. METHODS: A total of 304 consecutive subjects who underwent general health examinations including abdominal ultrasonography, transient elastography and abdominal fat computed tomography were prospectively enrolled...
2017: PloS One
Jeong Rye Kim, Chong Hyun Suh, Hee Mang Yoon, Jin Seong Lee, Young Ah Cho, Ah Young Jung
OBJECTIVE: To assess the diagnostic performance of shear-wave elastography for determining the severity of liver fibrosis in children and adolescents. METHODS: An electronic literature search of PubMed and EMBASE was conducted. Bivariate modelling and hierarchical summary receiver-operating-characteristic modelling were performed to evaluate the diagnostic performance of shear-wave elastography. Meta-regression and subgroup analyses according to the modality of shear-wave imaging and the degree of liver fibrosis were also performed...
October 10, 2017: European Radiology
Yutaka Sasaki, Yoshiki Hirooka, Hiroki Kawashima, Takuya Ishikawa, Kyosuke Takeshita, Hidemi Goto
Background Chronic kidney disease (CKD) patients have advanced glomerulosclerosis and renal interstitial fibrosis. Shear wave elastography (SWE) is useful to diagnose liver fibrosis. However, there are few data available regarding evaluation of kidney function on the use of SWE. Purpose To assess the utility of SWE by evaluating the correlation between renal function and renal elasticity using SWE. Material and Methods A total of 187 participants who had available serum creatinine levels and also underwent SWE of the kidney using a transabdominal ultrasonography were recruited at Nagoya University Hospital...
January 1, 2017: Acta Radiologica
Thomas Ebert, Nicolas Linder, Alexander Schaudinn, Harald Busse, Joachim Berger, Ralf Lichtinghagen, Volker Keim, Johannes Wiegand, Thomas Karlas
OBJECTIVE: The liver-derived plasma protein fetuin B is associated with nonalcoholic fatty liver disease (NAFLD) and impaired glucose homeostasis in mice. However, its association with non-invasive ultrasound- and magnetic resonance (MR)-based markers of liver fibrosis and steatosis, the enhanced liver fibrosis (ELF) score, liver biopsy, as well as rs738409 in PNPLA3, has not been elucidated in NAFLD, so far. DESIGN AND METHODS: The association of circulating fetuin B and transient elastography (TE), controlled attenuation parameter (CAP), (1)H-MR-spectroscopy, the ELF score, liver biopsy, as well as risk alleles in rs738409 in PNPLA3, was studied in 101 NAFLD patients as compared to 15 healthy controls...
November 2017: Endocrine
Grace L H Wong, Raymond Kwok, Aric J Hui, Yee-Kit Tse, Kai-Tin Ho, Angeline O S Lo, Kelvin L Y Lam, Heyson C H Chan, Rashid A Lui, Kenneth H D Au, Henry L Y Chan, Vincent W S Wong
BACKGROUND: Variceal bleeding is a common and life-threatening complication in patients with cirrhosis. Screening with upper endoscopy is recommended but is uncomfortable to patients. Non-invasive assessment with transient elastography for liver/spleen stiffness measurement (LSM and SSM) is accurate in detecting varices. AIMS: To test the hypothesis that a new screening strategy for varices guided by LSM/SSM results (LSSM-guided) is non-inferior to universal endoscopic screening in detecting clinically significant varices in patients with cirrhosis...
August 29, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
Preya Janubhai Patel, Kelly Lee Hayward, Rathiga Rudra, Leigh Ula Horsfall, Fabrina Hossain, Suzanne Williams, Tracey Johnson, Nigel Neil Brown, Nivene Saad, Andrew Donald Clouston, Katherine Anne Stuart, Patricia Casarolli Valery, Katharine Margaret Irvine, Anthony William Russell, Elizabeth Ellen Powell
An observational study describing the number and type of chronic conditions and medications taken by diabetic patients with NAFLD and identifying characteristics that may impact liver disease severity or clinical management.Adults with type 2 diabetes have a high prevalence of nonalcoholic fatty liver disease (NAFLD) and increased risk of developing advanced liver disease. Appropriate management should consider the characteristics of the diabetic NAFLD population, as comorbid conditions and medications may increase the complexity of treatment strategies...
June 2017: Medicine (Baltimore)
Caroline Jung, Michael Groth, Kay Uwe Petersen, Anna Hammel, Florian Brinkert, Enke Grabhorn, Sören Alexander Weidemann, Jasmin Busch, Gerhard Adam, Jochen Herrmann
OBJECTIVES: To compare hepatic 2D shear wave elastography (2D SWE) in children between free-breathing and breath-hold conditions, in terms of measurement agreement and time expenditure. METHODS: A cohort of 57 children (12.7±4.3 years) who underwent standardized 2D SWE between May and October 2015 were retrospectively evaluated. Liver elastograms were obtained under free-breathing and breath-hold conditions and time expenditure was measured. Median stiffness, interquartile range (IQR), and IQR/median ratio were calculated based on 12, six, and three elastograms...
December 2017: European Radiology
Louise J M Alferink, Juliana Fittipaldi, Jessica C Kiefte-de Jong, Pavel Taimr, Bettina E Hansen, Herold J Metselaar, Josje D Schoufour, M Arfan Ikram, Harry L A Janssen, Oscar H Franco, Sarwa Darwish Murad
BACKGROUND & AIMS: Coffee and tea have been proposed to limit the progression of liver fibrosis in established liver disease, but it is unknown if this is also true for subclinical fibrosis. We therefore aimed to evaluate whether coffee and tea consumption are associated with liver stiffness in the general population. METHODS: The Rotterdam Study is an ongoing prospective population-based cohort. We included participants who underwent transient elastography, ultrasound and completed a food frequency questionnaire...
August 2017: Journal of Hepatology
Benjamin Heidrich, Marius Vital, Iris Plumeier, Nico Döscher, Silke Kahl, Janina Kirschner, Szilvia Ziegert, Philipp Solbach, Henrike Lenzen, Andrej Potthoff, Michael Peter Manns, Heiner Wedemeyer, Dietmar Helmut Pieper
BACKGROUND & AIMS: The importance of the intestinal microbiota for the onset and clinical course of many diseases, including liver diseases like non-alcoholic steatohepatitis and cirrhosis, is increasingly recognized. However, the role of intestinal microbiota in chronic hepatitis C virus (HCV) infection remains unclear. METHODS: In a cross-sectional approach, the intestinal microbiota of 95 patients chronically infected with HCV (n=57 without cirrhosis [NO-CIR]; n=38 with cirrhosis [CIR]) and 50 healthy controls (HC) without documented liver diseases was analysed...
January 2018: Liver International: Official Journal of the International Association for the Study of the Liver
Ahmed M Gharib, Ma Ai Thanda Han, Eric G Meissner, David E Kleiner, Xiongce Zhao, Mary McLaughlin, Lindsay Matthews, Bisharah Rizvi, Khaled Z Abd-Elmoniem, Ralph Sinkus, Elliot Levy, Christopher Koh, Robert P Myers, G Mani Subramanian, Shyam Kottilil, Theo Heller, Joseph A Kovacs, Caryn G Morse
Background. Portal hypertension, an elevation in the hepatic venous pressure gradient (HVPG), can be used to monitor disease progression and response to therapy in cirrhosis. Since obtaining HVPG measurements is invasive, reliable noninvasive methods of assessing portal hypertension are needed. Methods. Noninvasive markers of fibrosis, including magnetic resonance elastography (MRE) shear wave velocity, were correlated with histologic fibrosis and HVPG measurements in hepatitis C (HCV) and/or HIV-infected patients with advanced liver disease enrolled in a clinical trial of treatment with simtuzumab, an anti-LOXL2 antibody...
2017: BioMed Research International
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