keyword
MENU ▼
Read by QxMD icon Read
search

Acetyl carnitine

keyword
https://www.readbyqxmd.com/read/29225006/mechanistic-studies-on-ketamine-induced-mitochondrial-toxicity-in-zebrafish-embryos
#1
Bonnie L Robinson, Melanie Dumas, Syed F Ali, Merle G Paule, Qiang Gu, Jyotshna Kanungo
Ketamine, a phencyclidine derivative, is an antagonist of the Ca2+-permeable N-methyl-d-aspartate (NMDA)-type glutamate receptors. It is a pediatric anesthetic and has been implicated in developmental neurotoxicity. Ketamine has also been shown to deplete ATP in mammalian cells. Our previous studies showed that acetyl l-carnitine (ALCAR) prevented ketamine-induced cardiotoxicity and neurotoxicity in zebrafish embryos. Based on our finding that ALCAR's protective effect was blunted by oligomycin A, an inhibitor of ATP synthase, we further investigated the effects of ketamine and ALCAR on ATP levels, mitochondria and ATP synthase in zebrafish embryos...
December 7, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/29224880/the-effect-of-different-treatments-for-early-lactation-hyperketonemia-on-liver-triglycerides-glycogen-and-expression-of-key-metabolic-enzymes-in-dairy-cattle
#2
S Mann, F A Leal Yepes, J J Wakshlag, E Behling-Kelly, J A A McArt
Despite the widespread use of treatments for postpartum hyperketonemia in dairy cows, there is currently a lack of evidence comparing their effects on both the resolution of hyperketonemia and the potential effects on the liver of affected animals. The objective of our work was to investigate the effect of commonly used hyperketonemia treatments on hepatic triglyceride and glycogen content as well as on the mRNA and protein abundance of key enzymes involved in gluconeogenesis, ketogenesis, and lipid metabolism...
December 7, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29221849/molecular-regulation-of-fatty-acid-oxidation-in-skeletal-muscle-during-aerobic-exercise
#3
REVIEW
Anne-Marie Lundsgaard, Andreas Mæchel Fritzen, Bente Kiens
This review summarizes how fatty acid (FA) oxidation is regulated in skeletal muscle during exercise. From the available evidence it seems that acetyl-CoA availability in the mitochondrial matrix adjusts FA oxidation to exercise intensity and duration. This is executed at the step of mitochondrial fatty acyl import, as the extent of acetyl group sequestration by carnitine determines the availability of carnitine for the carnitine palmitoyltransferase 1 (CPT1) reaction. The rate of glycolysis seems therefore to be central to the amount of β-oxidation-derived acetyl-CoA that is oxidized in the tricarboxylic acid (TCA) cycle...
December 5, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29195982/high-resolution-mass-approach-to-characterize-refrigerated-black-truffles-stored-under-different-storage-atmospheres
#4
Edoardo Longo, Ksenia Morozova, Monica R Loizzo, Rosa Tundis, Sara Savini, Roberta Foligni, Massimo Mozzon, Daniel Martin-Vertedor, Matteo Scampicchio, Emanuele Boselli
Freshly harvested Tuber melanosporum samples were packed and stored at 4°C under reduced atmospheric pressure or modified atmosphere for four weeks. Multivariate analysis was employed to correlate the antioxidant power of the ethanolic extracts of the samples with the chemical composition determined by high resolution mass spectrometry. High performance liquid chromatography coupled with a coularray detector was applied to select the chemical species associated with the antioxidant power. Four classes of chemical compounds were investigated in more detail by a targeted approach: derivatives of glutathione, adenine (such as S-adenosyl-homocysteine), oxidized linoleic acid and ergosterol...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29189995/acetyl-l-carnitine-attenuates-arsenic-induced-oxidative-stress-and-hippocampal-mitochondrial-dysfunction
#5
Hedieh Keshavarz-Bahaghighat, Mohammad Reza Sepand, Mohammad Hossein Ghahremani, Mehdi Aghsami, Nima Sanadgol, Ameneh Omidi, Vida Bodaghi-Namileh, Omid Sabzevari
Augmentation of mitochondrial oxidative stress through activating a series of deadly events has implicated as the main culprit of arsenic toxicity and therapeutic approaches based on improving mitochondrial function hold a great promise for attenuating the arsenic-induced toxicity. Acetyl-L-carnitine (ALC) through balancing the coenzyme A (CoA)/acyl-CoA ratio plays an important role in mitochondrial metabolism and thereby can help protect hippocampal neurons from oxidative damage. In the present study, we aimed to explore the effect of arsenic interactions on the mitochondrial function in the hippocampus of rats...
November 30, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29178253/kefir-peptides-prevent-hyperlipidemia-and-obesity-in-high-fat-diet-induced-obese-rats-via-lipid-metabolism-modulation
#6
Yu-Tang Tung, Hsiao-Ling Chen, Hsin-Shan Wu, Mei-Hsuan Ho, Kowit-Yu Chong, Chuan-Mu Chen
SCOPE: Obesity has reached epidemic proportions worldwide. Obesity is a complex metabolic disorder that is linked to numerous serious health complications with high morbidity. The present study evaluated the effects of kefir peptides on high fat diet-induced obesity in rats. METHODS AND RESULTS: Kefir peptides markedly improved obesity, including body weight gain, inflammatory reactions and the formation of adipose tissue fat deposits around the epididymis and kidney, and adipocyte size...
November 24, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29174039/lavatera-critica-a-green-leafy-vegetable-controls-high-fat-diet-induced-hepatic-lipid-accumulation-and-oxidative-stress-through-the-regulation-of-lipogenesis-and-lipolysis-genes
#7
Chinnadurai Veeramani, Mohammed A Alsaif, Khalid S Al-Numair
BACKGROUND: Lipid accumulation is the most vital risk factor for inducing nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome. Thus, the development of novel drugs is urgently needed to control obesity related diseases. OBJECTIVE: Here, we investigated the protective role of Lavatera critica (LC), a green vegetable, in male C57BL/6J mice fed with high fat (HF) diet for 10 weeks to induce hepatic lipid accumulation and oxidative cellular damage. RESULTS: After oral administration of chloroform (CFLC), ethyl acetate (EFLC), or methanol (MFLC) fractions of Lavatera critica to the HF group, EALC alone significantly reduced the activities of hepatic markers such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST); moreover, the results showed that 50 mg/kg dose has the maximum activity...
November 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29173234/dietary-%C3%AE-lactalbumin-induced-fatty-liver-by-enhancing-nuclear-liver-x-receptor-%C3%AE-%C3%AE-sterol-regulatory-element-binding-protein-1c-ppar%C3%AE-expression-and-minimising-ppar%C3%AE-carnitine-palmitoyltransferase-1-expression-and-amp-activated-protein-kinase-%C3%AE-phosphorylation
#8
María Elvira López-Oliva, Alba Garcimartin, Emilia Muñoz-Martínez
The effect and the role played by dietary α-lactalbumin (α-LAC) on hepatic fat metabolism are yet to be fully elucidated. We reported previously that α-LAC intake induced atherogenic dyslipidaemia in Balb/c mice. The aim of the present study was to investigate if this atherogenic effect could be due to a possible α-LAC-induced hepatic steatosis. We examine the ability of dietary α-LAC to induce liver steatosis, identifying the molecular mechanisms underlying hepatic lipid metabolism in association with the lipid profile, peripheral insulin resistance (IR) and changes in the hepatic oxidative environment...
November 27, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29164469/antibiotic-anisomycin-induces-cell-cycle-arrest-and-apoptosis-through-inhibiting-mitochondrial-biogenesis-in-osteosarcoma
#9
Chuanhua Cao, Haiying Yu, Feng Wu, Huixiong Qi, Jingbo He
The anti-cancer activities of antibiotic anisomycin have been demonstrated in kidney, colon and ovarian cancers whereas its underlying mechanisms are not well elucidated. In this work, we investigated whether anisomycin is effective in sensitizes osteosarcoma cell response to chemotherapy. We show that anisomycin inhibits proliferation via inducing osteosarcoma cell arrest at G2/M phase, accompanied by the increased levels of mitotic marker cyclin B and the decreased levels of Rb and E2F-1. Anisomycin also induces apoptosis in a caspase-dependent manner in osteosarcoma cells...
November 21, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29159461/severe-hyperammonemic-encephalopathy-requiring-dialysis-aggravated-by-prolonged-fasting-and-intermittent-high-fat-load-in-a-ramadan-fasting-month-in-a-patient-with-cptii-homozygous-mutation
#10
P Phowthongkum, C Ittiwut, V Shotelersuk
BACKGROUND: Carnitine palmitoyltransferase II (CPTII) deficiency is a mitochondrial fatty acid oxidation disorder that can present antenatally as congenital brain malformations, or postnatally with lethal neonatal, severe infantile, or the most common adult myopathic forms. No case of severe hyperammonemia without liver dysfunction has been reported. CASE PRESENTATION: We described a 23-year-old man who presented to the emergency department with seizures and was found to have markedly elevation of serum ammonia...
November 21, 2017: JIMD Reports
https://www.readbyqxmd.com/read/29139118/di-2-ethylhexyl-phthalate-dehp-exposure-disturbs-lipid-metabolism-in-juvenile-yellow-catfish-tachysurus-fulvidraco
#11
F X Meng, M Li, M Z Song, L X Yuan, Y F Gong, Y X Qian, G Shi, R X Wang
This study was conducted to determine the mechanism by which di-2-ethylhexyl phthalate (DEHP) exposure influences lipid metabolism of juvenile yellow catfish Tachysurus fulvidraco. Fish were exposed to three DEHP concentrations (0, 0·1 and 0·5 mg l(-1) DEHP) for 8 weeks. Fatty acid synthase (FAS) activity significantly decreased with increasing DEHP concentrations, the highest value was in the Tween control group, whereas the lowest activities of carnitine palmitoyltransferase (CPT) and lipoprotein lipase (LPL) were in this group...
November 15, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/29138817/reduced-triglyceride-accumulation-due-to-overactivation-of-farnesoid-x-receptor-signaling-contributes-to-impaired-liver-regeneration-following-50-hepatectomy-in-extra%C3%A2-cholestatic-liver-tissue
#12
Wen-Jun Jia, Shi-Quan Sun, Luo-Shun Huang, Qiao-Li Tang, Yu-Dong Qiu, Liang Mao
The aim of the present study was to investigate the role of triglyceride metabolism in the effect of obstructive cholestasis on liver regeneration following 50% partial hepatectomy (PH). Obstructive cholestatic rat models were achieved via ligation of the common bile duct (BDL). Following comparisons between hepatic pathological alterations with patients with perihilar cholangiocarcinoma, rats in the 7 day post‑BDL group were selected as the BDL model for subsequent experiments. Liver weight restoration, proliferating cell nuclear antigen labeling index, cytokine and growth factor expression levels, and hepatic triglyceride content were evaluated to analyze liver regeneration post‑PH within BDL and control group rats...
November 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29136144/antioxidants-improve-ivf-outcome-and-subsequent-embryo-development-in-the-mouse
#13
T Truong, D K Gardner
STUDY QUESTION: What is the effect of a combination of three antioxidants (Acetyl-L-Carnitine, N-Acetyl-L-Cysteine and α-Lipoic Acid), present in IVF medium during mouse oocyte and sperm collection, on fertilization and subsequent IVF embryo development? SUMMARY ANSWER: A combination of antioxidants resulted in faster developmental times from the 2-cell stage through to expanded blastocyst stage, accompanied by a significant increase in blastocyst cell number and a reduction of intracellular hydrogen peroxide (H2O2) levels...
December 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29129455/plasma-palmitoyl-carnitine-ac16-0-is-a-marker-of-increased-postprandial-nonesterified-incomplete-fatty-acid-oxidation-rate-in-individuals-with-type-2-diabetes
#14
Fatima-Zahra Bouchouirab, Mélanie Fortin, Christophe Noll, Jean Dubé, André C Carpentier
OBJECTIVES: Enhanced mitochondrial fatty acid utilization is known to increase radical oxidative stress and induce insulin resistance. An increased level of plasma acylcarnitine (AC) has been proposed to indicate mitochondrial energy substrate overload, a possible mechanism leading to insulin resistance. The aim of our study was to determine fasting and postprandial plasma acetyl-carnitine (AC2:0), palmitoyl-carnitine (AC16:0), oleoyl-carnitine (AC18:1) and linoleoyl-carnitine (AC18:2) levels and their relationships with plasma nonesterified fatty acid appearance and oxidation rates and insulin sensitivity in participants with type 2 diabetes and normoglycemic offspring of 2 parents with type 2 diabetes (FH+) compared to healthy participants without family histories of type 2 diabetes (FH-)...
November 9, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29115530/curcumin-suppresses-notch%C3%A2-1-signaling-improvements-in-fatty-liver-and-insulin-resistance-in-rats
#15
Neng-Jiang Zhao, Ming-Juan Liao, Jing-Jing Wu, Ke-Xin Chu
Curcumin is a well‑known phenolic substance and has many pharmacological effects associated with metabolism. However, the exact molecular mechanisms underlying this process have yet to be determined. The Notch pathway is a signal transduction pathway involved in energy metabolism. The present study aimed to investigate the effects of curcumin administration on glucose‑lipid metabolism in rats subjected to a high fat diet, and investigate changes in Notch‑1 signaling. Sprague‑Dawley rats (n=40) were randomly divided into four groups (10 rats/group): Control diet group, high fat diet group, high fat diet plus curcumin low dose group and high fat diet plus curcumin high dose group...
November 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29076953/acetyl-l-carnitine-supplementation-and-the-treatment-for-depressive-symptoms-a-systematic-review-and-meta-analysis
#16
Nicola Veronese, Brendon Stubbs, Marco Solmi, Olesya Ajnakina, Andre F Carvalho, Stefania Maggi
OBJECTIVE: Deficiency of acetyl-L-carnitine (ALC) appears to play a role in the risk of developing depression, indicating dysregulation of fatty acids transport across the inner membrane of mitochondria. However, the data regarding ALC supplementation in humans are limited.. We thus conducted a systematic review and meta-analysis investigating the effect of ALC on depressive symptoms across randomized controlled trials (RCTs). METHODS: A literature search in major databases, without language restriction, was undertaken from inception until 30 December 2016...
October 25, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29071700/-treatment-of-encephalopathy-by-means-of-valproic-acid-with-carglumic-acid-two-case-reports-and-a-review-of-the-literature
#17
J J Nava-Mateos, P Roiz-Rey, J Diaz Alvarez-Mediavilla, D Cebrian-Novella, V Gomez-Del Olmo, L Ceberio-Hualde
INTRODUCTION: Valproic acid (VPA) is a drug mainly used to treat epilepsy. Hyperammonaemic encephalopathy due to VPA is a rare but serious complication. The mechanism by which VPA influences the increase in ammonia consists in blocking the urea cycle, thereby inhibiting N-acetylglutamate synthase and diminishing acetyl coenzyme A. Generally, the treatment employed has been to withdraw VPA and to administer arginine, carnitine, antibiotics, glucose and protein restriction. Previous experience with carglumic acid is limited to reports of isolated cases of paediatric patients...
November 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/29033604/chronic-pain-and-adult-hippocampal-neurogenesis-translational-implications-from-preclinical-studies
#18
Mariagrazia Grilli
Adult hippocampal neurogenesis (ahNG) occurs in the human brain. Adult generated neurons have been proposed to functionally contribute to relevant hippocampal functions such as learning and memory, mood regulation, and stress response. Learning, environmental enrichment, and physical exercise exert positive effects on ahNG. In parallel, these proneurogenic stimuli have been shown to ameliorate cognitive performance and/or depressive-like behavior in animal models. Conversely, aging, social isolation, and chronic stress exert negative effects on ahNG...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29024663/role-of-the-astroglial-glutamate-exchanger-xct-in-ventral-hippocampus-in-resilience-to-stress
#19
Carla Nasca, Benedetta Bigio, Danielle Zelli, Paolo de Angelis, Timothy Lau, Masahiro Okamoto, Hideyo Soya, Jason Ni, Lars Brichta, Paul Greengard, Rachael L Neve, Francis S Lee, Bruce S McEwen
We demonstrate that stress differentially regulates glutamate homeostasis in the dorsal and ventral hippocampus and identify a role for the astroglial xCT in ventral dentate gyrus (vDG) in stress and antidepressant responses. We provide an RNA-seq roadmap for the stress-sensitive vDG. The transcription factor REST binds to xCT promoter in co-occupancy with the epigenetic marker H3K27ac to regulate expression of xCT, which is also reduced in a genetic mouse model of inherent susceptibility to depressive-like behavior...
October 11, 2017: Neuron
https://www.readbyqxmd.com/read/29024108/changes-in-hepatic-glucose-and-lipid-metabolism-related-parameters-in-domestic-pigeon-columba-livia-during-incubation-and-chick-rearing
#20
X P Wan, P Xie, Z Bu, X T Zou
This study aimed to evaluate the hepatic glucose and lipid metabolism-related parameters of adult male and female White King pigeons (Columba livia) during incubation and chick rearing. At day 4 (I4), 10 (I10) and 17 (I17) of incubation and day 1 (R1), 7 (R7), 15 (R15) and 25 (R25) of chick rearing, livers were sampled from six pigeons for each sex. Glycogen and fat contents, activities of glycolytic enzymes (hexokinase, HK; 6-phosphofructokinase, 6-PFK), and genes expressions of key enzymes involved in glycolysis (pyruvate kinase, PK; glucokinase, GK), gluconeogenesis (phosphoenolpyruvate carboxykinase cytosolic, PCK1; fructose-1,6-bisphosphatase, FBP1; glucose-6-phosphatase, G6Pase), fatty acid synthesis (fatty acid synthase, FAS; acetyl-CoA carboxylase, ACC) and fatty acid β-oxidation (carnitine palmitoyltransferase 1, CPT1; acyl-CoA 1, ACO) were measured...
October 12, 2017: Journal of Animal Physiology and Animal Nutrition
keyword
keyword
90961
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"