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https://www.readbyqxmd.com/read/28743160/the-prognostic-utility-of-baseline-alpha-fetoprotein-for-hepatocellular-carcinoma-patients
#1
Jack P Silva, Richard A Gorman, Nicholas G Berger, Susan Tsai, Kathleen K Christians, Callisia N Clarke, Harveshp Mogal, T Clark Gamblin
INTRODUCTION: Alpha-fetoprotein (AFP) has a valuable role in postoperative surveillance for hepatocellular carcinoma (HCC) recurrence. The utility of pretreatment or baseline AFP remains controversial. The present study hypothesized that elevated baseline AFP levels are associated with worse overall survival in HCC patients. METHODS: Adult HCC patients were identified using the National Cancer Database (2004-2013). Patients were stratified according to baseline AFP measurements into the following groups: Negative (<20), Borderline (20-199), Elevated (200-1999), and Highly Elevated (>2000)...
July 25, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28743156/components-of-mesophyll-resistance-and-their-environmental-responses-a-theoretical-modeling-analysis
#2
Yi Xiao, Xin-Guang Zhu
Mesophyll resistance (rm ), together with stomatal resistance and biochemical limitations, are recognized as three critical factors limiting leaf photosynthesis. Contrary to the expectation of being a constant, rm not only varies with light and CO2 conditions but also shows different responses among species. To elucidate the mechanistic basis of these responses, we derived an analytical model of rm , which incorporates various anatomical and biochemical factors including permeabilities of cell wall and chloroplast envelope to CO2 and HCO3(-) , carbonic anhydrase activities in cytosol and stroma, Rubisco activities, and relative location of mitochondria and chloroplast...
July 25, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28743089/understanding-the-interaction-of-concanavalin-a-with-mannosyl-glycoliposomes-a-surface-plasmon-resonance-and-fluorescence-study
#3
Catalina Sandoval-Altamirano, Susana A Sanchez, Nancy F Ferreyra, German Gunther
The specificity of carbohydrate-protein interaction is a key factor in many biological processes and it is the foundation of technologies using glycoliposomes in drug delivery. The incorporation of glycolipids in vesicles is expected to increase their specificity toward particular targets such as lectins; however, the degree of exposure of the carbohydrate moiety at the liposome surface is a crucial parameter to be considered in the interaction. Herein we report the synthesis of mannose derivatives with one or two hydrophobic chains of different length, designed with the purpose of modifying the degree of exposure of the mannose when they were incorporated into liposomes...
July 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28743077/characterization-and-quantitative-analysis-of-phenolic-derivatives-in-longxuetongluo-capsule-by-hplc-dad-it-tof-ms
#4
Jing Sun, Yuelin Song, Hui Sun, Wenjing Liu, Yunfeng Zhang, Jiao Zheng, Qian Zhang, Yunfang Zhao, Wei Xiao, Pengfei Tu, Jun Li
Longxuetongluo Capsule (LTC), which is derived from the total phenolic extract of Chinese dragon's blood, has been proved to be safe as well as effective towards ischemic stroke. However, the effective material basis remains unclear. The present study thereby focused on the clarification of the qualitative and quantitative properties for the phenolic derivatives in LTC. Regarding homolog-focused chemical profiling, the mass fragmentation patterns of the primary subtypes of phenolic compounds such as homoisoflavanones, flavanes, chalcones, and flavonoid oligomers were summarized by assaying authentic references with hybrid ion trap time-of-flight mass spectrometry, and the chemical structures of 124 phenolic compounds, in total, were unambiguously or tentatively annotated in LTC by matching the accurate mass spectral profiles with the proposed mass cracking rules and those reference substances...
July 14, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28743035/current-trials-to-reduce-surgical-intervention-in-ductal-carcinoma-in-situ-of-the-breast-critical-review
#5
REVIEW
M Toss, I Miligy, A M Thompson, H Khout, A R Green, I O Ellis, E A Rakha
The high proportion of ductal carcinoma in situ (DCIS) presented in mammographic screening and the relatively low risk of progression to invasive disease have raised questions related to overtreatment. Following a review of current DCIS management protocols a more conservative approach has been suggested. Clinical trials have been introduced to evaluate the option of avoiding surgical intervention in a proportion of patients with DCIS defined as "low-risk" using certain clinicopathological criteria. These trials can potentially provide evidence-based models of active surveillance (with or without endocrine therapy) as a future management approach...
July 22, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28742985/gabab-receptors-suppress-burst-firing-in-reticular-thalamic-neurons
#6
Stuart M Cain, Esperanza Garcia, Zeina Waheed, Karen L Jones, Trevor J Bushell, Terrance P Snutch
Burst-firing in thalamic neurons is known to play a key role in mediating thalamocortical (TC) oscillations that are associated with non-REM sleep and some types of epileptic seizure. Within the TC system the primary output of GABAergic neurons in the reticular thalamic nucleus (RTN) is thought to induce the de-inactivation of T-type calcium channels in thalamic relay (TR) neurons, promoting burst-firing drive to the cortex and the propagation of TC network activity. However, RTN neurons also project back onto other neurons within the RTN...
July 25, 2017: Channels
https://www.readbyqxmd.com/read/28742938/sexes-in-gynodioecious-geranium-sylvaticum-do-not-differ-in-their-isotopic-signature-or-photosynthetic-capacity
#7
Sandra Varga, Minna-Maarit Kytöviita
In gynodioecious plants, females are expected to produce more or better seeds than hermaphrodites in order to be maintained within the same population. Even though rarely measured, higher seed production can be achieved through differences in physiology. In this work, we measured sexual dimorphism in several physiological traits in the gynodioecious plant Geranium sylvaticum. Photosynthetic rate, stomatal conductivity, transpiration rate, water use efficiency and isotopic signatures were measured in plants growing in two habitats differing in light availability...
July 25, 2017: Plant Biology
https://www.readbyqxmd.com/read/28742930/information-about-first-trimester-screening-and-self-reported-distress-among-pregnant-women-and-partners-comparing-two-methods-of-information-giving-in-sweden
#8
Peter Lindgren, Magdalena Stadin, Inger Blomberg, Karin Nordin, Hanna Sahlgren, Charlotta Ingvoldstad Malmgren
INTRODUCTION: Balanced information prior to prenatal diagnosis (PND) aims to help expectant parents to make an informed choice. However, it is important that the information does not increase the expectant parents' psychological distress. The aim was to examine psychological distress among expectant parents, before and after receiving information about PND, to evaluate the possible differences between two different procedures of information giving, and to evaluate the association between satisfaction with the information and psychological distress...
July 25, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28742873/orienting-towards-social-features-in-naturalistic-scenes-is-reflexive
#9
Lara Rösler, Albert End, Matthias Gamer
Saliency-based models of visual attention postulate that, when a scene is freely viewed, attention is predominantly allocated to those elements that stand out in terms of their physical properties. However, eye-tracking studies have shown that saliency models fail to predict gaze behavior accurately when social information is included in an image. Notably, gaze pattern analyses revealed that depictions of human beings are heavily prioritized independent of their low-level physical saliency. What remains unknown, however, is whether the prioritization of such social features is a reflexive or a voluntary process...
2017: PloS One
https://www.readbyqxmd.com/read/28742846/endophytic-fungal-communities-of-polygonum-acuminatum-and-aeschynomene-fluminensis-are-influenced-by-soil-mercury-contamination
#10
William Pietro-Souza, Ivani Souza Mello, Suzana Junges Vendruscullo, Gilvan Ferreira da Silva, Cátia Nunes da Cunha, James Francis White, Marcos Antônio Soares
The endophytic fungal communities of Polygonum acuminatum and Aeschynomene fluminensis were examined with respect to soil mercury (Hg) contamination. Plants were collected in places with and without Hg+2 for isolation and identification of their endophytic root fungi. We evaluated frequency of colonization, number of isolates and richness, indices of diversity and similarity, functional traits (hydrolytic enzymes, siderophores, indoleacetic acid, antibiosis and metal tolerance) and growth promotion of Aeschynomene fluminensis inoculated with endophytic fungi on soil with mercury...
2017: PloS One
https://www.readbyqxmd.com/read/28742831/deterministic-stability-and-random-behavior-of-a-hepatitis-c-model
#11
Mehmet Merdan, Zafer Bekiryazici, Tulay Kesemen, Tahir Khaniyev
The deterministic stability of a model of Hepatitis C which includes a term defining the effect of immune system is studied on both local and global scales. Random effect is added to the model to investigate the random behavior of the model. The numerical characteristics such as the expectation, variance and confidence interval are calculated for random effects with two different distributions from the results of numerical simulations. In addition, the compliance of the random behavior of the model and the deterministic stability results is examined...
2017: PloS One
https://www.readbyqxmd.com/read/28742809/dimensions-of-antenatal-care-service-and-the-alacrity-of-mothers-towards-institutional-delivery-in-south-and-south-east-asia
#12
Priyanka Dixit, Junaid Khan, Laxmi Kant Dwivedi, Amrita Gupta
BACKGROUND: A number of studies have assessed the effectiveness of antenatal care (ANC) on uptake of institutional delivery care. However, none address the issue of association between the different components of ANC i.e. ANC component which is independent of health care delivery systems (timing and number of ANC visits), ANC components which depends on health care delivery systems (specific ANC procedures that women receive) with institutional delivery. METHODS: Data for the study has been taken from the DHS conducted in the six selected South and South-East Asian countries during 1998-2013...
2017: PloS One
https://www.readbyqxmd.com/read/28742794/the-cost-effectiveness-of-screening-for-ovarian-cancer-results-from-the-uk-collaborative-trial-of-ovarian-cancer-screening-ukctocs
#13
Usha Menon, Alistair J McGuire, Maria Raikou, Andy Ryan, Susan K Davies, Matthew Burnell, Aleksandra Gentry-Maharaj, Jatinderpal K Kalsi, Naveena Singh, Nazar N Amso, Derek Cruickshank, Stephen Dobbs, Keith Godfrey, Jonathan Herod, Simon Leeson, Tim Mould, John Murdoch, David Oram, Ian Scott, Mourad W Seif, Karin Williamson, Robert Woolas, Lesley Fallowfield, Stuart Campbell, Steven J Skates, Mahesh Parmar, Ian J Jacobs
BACKGROUND: To assess the within-trial cost-effectiveness of an NHS ovarian cancer screening (OCS) programme using data from UKCTOCS and extrapolate results based on average life expectancy. METHODS: Within-trial economic evaluation of no screening (C) vs either (1) an annual OCS programme using transvaginal ultrasound (USS) or (2) an annual ovarian cancer multimodal screening programme with serum CA125 interpreted using a risk algorithm (ROCA) and transvaginal ultrasound as a second-line test (MMS), plus comparison of lifetime extrapolation of the no screening arm and the MMS programme using both a predictive and a Markov model...
July 25, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28742757/concurrent-validity-and-responsiveness-of-promis-health-domains-among-patients-presenting-for-anterior-cervical-spine-surgery
#14
Taylor E Purvis, Elena Andreou, Brian J Neuman, Lee H Riley, Richard L Skolasky
STUDY DESIGN: Prospective cohort study. OBJECTIVE: To determine validity and responsiveness of Patient-Reported Outcomes Measurement Information System (PROMIS) health domains. SUMMARY OF BACKGROUND DATA: PROMIS health domains (anxiety, depression, fatigue, pain, physical function, satisfaction with participation in social roles, sleep disturbance) may measure quality of care and determine minimal important differences (MIDs) after spine surgery...
July 24, 2017: Spine
https://www.readbyqxmd.com/read/28742711/readiness-of-us-general-surgery-residents-for-independent-practice
#15
Brian C George, Jordan D Bohnen, Reed G Williams, Shari L Meyerson, Mary C Schuller, Michael J Clark, Andreas H Meier, Laura Torbeck, Samuel P Mandell, John T Mullen, Douglas S Smink, Rebecca E Scully, Jeffrey G Chipman, Edward D Auyang, Kyla P Terhune, Paul E Wise, Jennifer N Choi, Eugene F Foley, Justin B Dimick, Michael A Choti, Nathaniel J Soper, Keith D Lillemoe, Joseph B Zwischenberger, Gary L Dunnington, Debra A DaRosa, Jonathan P Fryer
OBJECTIVE: This study evaluates the current state of the General Surgery (GS) residency training model by investigating resident operative performance and autonomy. BACKGROUND: The American Board of Surgery has designated 132 procedures as being "Core" to the practice of GS. GS residents are expected to be able to safely and independently perform those procedures by the time they graduate. There is growing concern that not all residents achieve that standard. Lack of operative autonomy may play a role...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742684/endovascular-repair-of-abdominal-aortic-aneurysm-in-patients-physically-ineligible-for-open-repair-very-long-term-follow-up-in-the-evar-2-randomized-controlled-trial
#16
Michael J Sweeting, Rajesh Patel, Janet T Powell, Roger M Greenhalgh
OBJECTIVE: The aim of the study was to compare long-term total and aneurysm-related mortality in physically frail patients with abdominal aortic aneurysm (AAA) randomized to either early endovascular aneurysm repair (EVAR) or no-intervention. SUMMARY BACKGROUND DATA: EVAR-2 remains the sole randomized trial to identify whether EVAR reduces mortality in patients physically ineligible for open repair. METHODS: Between September 1999 and August 2004, 404 patients from 33 centers in the United Kingdom aged ≥60 years with AAA >5...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742675/committee-opinion-no-710-counseling-adolescents-about-contraception
#17
(no author information available yet)
Modern contraceptives are very effective when used correctly and, thus, effective counseling regarding contraceptive options and provision of resources to increase access are key components of adolescent health care. Regardless of a patient's age or previous sexual activity, the obstetrician-gynecologist routinely should address her contraceptive needs, expectations, and concerns. Obstetrician-gynecologists should be aware of and be prepared to address the most common misperceptions about contraceptive methods in a way that is age appropriate and compatible with the patient's health literacy...
August 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28742669/committee-opinion-no-710-summary-counseling-adolescents-about-contraception
#18
(no author information available yet)
Modern contraceptives are very effective when used correctly and, thus, effective counseling regarding contraceptive options and provision of resources to increase access are key components of adolescent health care. Regardless of a patient's age or previous sexual activity, the obstetrician-gynecologist routinely should address her contraceptive needs, expectations, and concerns. Obstetrician-gynecologists should be aware of and be prepared to address the most common misperceptions about contraceptive methods in a way that is age appropriate and compatible with the patient's health literacy...
August 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28742622/rational-therapeutic-choice-for-older-patients-with-lymphoma
#19
Dominique Bron, Pierre Soubeyran
PURPOSE OF REVIEW: The choice for an optimal treatment in older lymphoma patients is a real challenge for hemato-oncologists. They have to treat a potentially curative lymphoma, and concomitantly protect their patients from unacceptable toxicities. Some recommendations are provided for the major subtypes of lymphomas including the antitumoral treatment and primarily the optimal supportive care. RECENT FINDINGS: All the recent literature data converge to say that the approach of an older patient with a malignant hemopathy is a multistep procedure...
July 22, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28742590/failed-intrauterine-pregnancy-what-is-a-failed-pregnancy-what-is-not
#20
Timothy P Canavan
Pregnancy failure is defined as a lack of sonographic evidence of current or expected viability. Technologic advances in ultrasound imaging continue to redefine diagnostic criteria of pregnancy failure or success. When evaluating a pregnancy, the first step is an assessment of maternal risk factors for failure. Imaging clues such as an empty gestational sac measuring ≥25 mm or an embryo ≥7 mm without cardiac activity are reliable signs of pregnancy failure, whereas embryonic growth <1 mm/d is not. Combinations of sonographic findings can be used for a more accurate prediction of pregnancy success or failure...
September 2017: Clinical Obstetrics and Gynecology
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