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https://www.readbyqxmd.com/read/29141350/-comparison-of-different-methods-in-dealing-with-hiv-viral-load-data-with-diversified-missing-value-mechanism-on-hiv-positive-msm
#1
Z Jiang, Z Dou, W L Song, J Xu, Z Y Wu
Objective: To compare results of different methods: in organizing HIV viral load (VL) data with missing values mechanism. Methods We used software SPSS 17.0 to simulate complete and missing data with different missing value mechanism from HIV viral loading data collected from MSM in 16 cities in China in 2013. Maximum Likelihood Methods Using the Expectation and Maximization Algorithm (EM), regressive method, mean imputation, delete method, and Markov Chain Monte Carlo (MCMC) were used to supplement missing data respectively...
November 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29141244/exploring-parental-expectations-and-experiences-around-gentle-and-standard-caesarean-section
#2
Jolien Onsea, Bernadette Bijnens, Siska Van Damme, Tim Van Mieghem
BACKGROUND/AIMS: "Gentle" or "natural" cesarean sections are implemented to improve parental satisfaction. The objective of this study was to investigate whether there is a need for adopting such a gentle approach. METHODS: We recruited those with low-risk pregnancies scheduled for elective cesarean delivery at term. Three questionnaires were administered to both partners: prior to delivery, 2-5 days after delivery, and 6 weeks postpartum. Questionnaires assessed the couple's expectations, fears, and satisfaction prior to and after cesarean section...
November 16, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29141187/factors-associated-with-final-year-nursing-students-desire-to-work-in-the-primary-health-care-setting-findings-from-a-national-cross-sectional-survey
#3
Jacqueline G Bloomfield, Christina Aggar, Tamsin H T Thomas, Christopher J Gordon
BACKGROUND: Registered nurses are under-represented in the primary health care setting both internationally and in Australia, and this shortage is predicted to worsen. To address the increasingly complex healthcare needs of an ageing population, it is vital to develop and sustain a primary health care nursing workforce, yet attracting nurses is challenging. In Australia, registered nurses graduating from university typically commence their careers in hospital-based transition to professional practice programs...
October 23, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29141128/immune-enhancing-effect-of-nanometric-lactobacillus-plantarum-nf1-nlp-nf1-in-a-mouse-model-of-cyclophosphamide-induced-immunosuppression
#4
Dae-Woon Choi, Sun Young Jung, Jisu Kang, Young-Do Nam, Seong-Il Lim, Ki Tae Kim, Hee Soon Shin
Nanometric Lactobacillus plantarum nF1 (nLp-nF1) is a biogenics consisting of dead L. plantarum pre-treated with heat and a nanodispersion process. In this study, we investigated the immune-enhancing effects of nLp-nF1 in vivo and in vitro. To evaluate the immunostimulatory effects of nLp-nF1, mice immunosuppressed by cyclophosphamide (CPP) treatment were administered with nLp-nF1. As expected, CPP restricted the immune response of mice, whereas oral administration of nLp-nF1 significantly increased total IgG in serum, and cytokine production [interleukin-12 (IL-12) and tumor necrosis factor alpha (TNF-α)] in bone marrow cells...
November 15, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29141086/use-of-entrustable-professional-activities-in-the-assessment-of-surgical-resident-competency
#5
Justin P Wagner, Catherine E Lewis, Areti Tillou, Vatche G Agopian, Chi Quach, Timothy R Donahue, O Joe Hines
Importance: Competency-based assessments of surgical resident performance require metrics of entrustable autonomy. Objectives: To designate entrustable professional activities (EPAs) in global performance and in specific operations, and to identify differences in perceived capability, autonomy, and expectations between surgical faculty and residents. Design, Setting, and Participants: This survey study was conducted from August 9, 2016, through August 24, 2016, in the Department of Surgery at the UCLA David Geffen School of Medicine...
November 15, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29141044/high-dimensional-linear-state-space-models-for-dynamic-microbial-interaction-networks
#6
Iris Chen, Yogeshwar D Kelkar, Yu Gu, Jie Zhou, Xing Qiu, Hulin Wu
Medical researchers are increasingly interested in knowing how the complex community of micro-organisms living on human body impacts human health. Key to this is to understand how the microbes interact with each other. Time-course studies on human microbiome indicate that the composition of microbiome changes over short time periods, primarily as a consequence of synergistic and antagonistic interactions of the members of the microbiome with each other and with the environment. Knowledge of the abundance of bacteria-which are the predominant members of the human microbiome-in such time-course studies along with appropriate mathematical models will allow us to identify key dynamic interaction networks within the microbiome...
2017: PloS One
https://www.readbyqxmd.com/read/29141017/temozolomide-post-pazopanib-treatment-failure-in-patients-with-advanced-sarcoma-a-case-series
#7
Manojkumar Bupathi, John L Hays, James L Chen
BACKGROUND: Sarcomas are rare, heterogeneous tumors for which prognosis remains dismal in patients with advanced disease. Pazopanib, a vascular endothelial growth factor receptor inhibitor, has shown modest efficacy in patients with soft tissue sarcoma who fail cytotoxic chemotherapy. The cytotoxic agent temozolomide has also demonstrated activity in patients with advanced sarcoma. OBJECTIVE: We performed a retrospective case series to evaluate the feasibility of adding temozolomide to pazopanib in advanced sarcoma patients following single-agent pazopanib failure...
2017: PloS One
https://www.readbyqxmd.com/read/29140949/predictive-ability-and-interobserver-reliability-of-computed-tomography-findings-for-angioembolization-in-patients-with-pelvic-fracture
#8
Shunsuke Yoshikawa, Atsushi Shiraishi, Mitsuhiro Kishino, Makiko Honda, Nao Urushibata, Kosuke Sekiya, Tomohisa Shoko, Yasuhiro Otomo
BACKGROUND: The purpose of this study was to identify computed tomography (CT) findings that predict the need for angioembolization in patients with pelvic fracture. METHODS: This retrospective cross-sectional study was performed between April 2006 and October 2015 at two urban emergency medical centers in Japan. The study included patients who underwent CT within 3 hours of arrival and were diagnosed with a pelvic fracture. The study outcome was undergoing angioembolization within 24 hours of arrival...
November 14, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29140936/increased-kawasaki-disease-incidence-associated-with-higher-precipitation-and-lower-temperatures-japan-1991-2004
#9
Joseph Y Abrams, Jennifer L Blase, Ermias B Belay, Ritei Uehara, Ryan A Maddox, Lawrence B Schonberger, Yosikazu Nakamura
BACKGROUND: Kawasaki disease (KD) is an acute febrile vasculitis which primarily affects children. The etiology of KD is unknown: while certain characteristics of the disease suggest an infectious origin, genetic or environmental factors may also be important. Seasonal patterns of KD incidence are well-documented, but it is unclear whether these patterns are caused by changes in climate or by other unknown seasonal effects. METHODS: The relationship between KD incidence and deviations from expected temperature and precipitation were analyzed using KD incidence data from Japanese nationwide epidemiological surveys (1991-2004) and climate data from 136 weather stations of the Japan Meteorological Agency...
November 14, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29140898/a-construct-validation-study-of-playfun
#10
John Cairney, Scott Veldhuizen, Jeffrey D Graham, Christine Rodriguez, Chloe Bedard, Emily Bremer, Dean Kriellaars
INTRODUCTION: PLAYfun is a measure of motor competence, comprehension and confidence which is part of a suite of scales used to assess physical literacy in children and youth. However, its measurement properties have not been reported in the published literature. The purpose of this study is to examine the factor structure of PLAYfun, in addition to variations in PLAYfun subscale results by age and sex. METHOD: In this study, we use a sample of children and youth aged 7 to 14 years (n=215) to test a proposed factor structure for the motor competence component of PLAYfun and to examine age and sex differences in subscale and total scores...
November 15, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29140890/selecting-an-hiv-test-a-narrative-review-for-clinicians-and-researchers
#11
Christopher B Hurt, Julie A E Nelson, Lisa B Hightow-Weidman, William C Miller
Given the many options available, selecting an HIV test for a particular clinical or research setting can be daunting. Making an informed decision requires an assessment of the likelihood of acute infection in the test population and an understanding of key aspects of the tests themselves. The ability of individual tests to reliably detect HIV infection depends on the target(s) being detected, when they can be expected to be present after infection, and the concentration of stable target in test specimens, all of which are explained by the virologic and serologic events after infection...
December 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29140878/clear-cell-renal-cell-carcinoma-metastatic-to-the-gynecologic-tract-a-clinicopathologic-analysis-of-17-cases
#12
Oluwole Fadare, Mohamed M Desouki, Katja Gwin, Krisztina Z Hanley, Elke A Jarboe, Sharon X Liang, Charles M Quick, Kojo R Rawish, Andres A Roma, Wenxin Zheng, Jonathan L Hecht, Vinita Parkash, Adeboye O Osunkoya
Clear cell renal cell carcinomas (CCRCC) rarely metastasizes to the gynecologic tract. In this study, we analyzed a multi-institutional data set to provide insights into the clinical, morphologic, and immunophenotypic features of this phenomenon. Seveteen metastatic CCRCC involving the gynecologic tract [ovary/fallopian tube (n=9), vulva (n=2), uterine corpus (n=3), cervix (n=2), uterine serosa (n=1)] were analyzed. Mean patient age was 62 yr (range: 45-79 yr). Most cases (15/17) presented as a recurrence 6 to 72 mo postnephrectomy, 1 case was concurrently diagnosed, and 1 case (a cervical metastasis) was diagnosed prenephrectomy...
November 14, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29140873/experienced-hiv-related-stigma-in-healthcare-and-community-settings-mediated-associations-with-psychosocial-and-health-outcomes
#13
Emma Sophia Kay, Whitney S Rice, Kaylee B Crockett, Ghislaine C Atkins, D Scott Batey, Bulent Turan
INTRODUCTION: There are multiple dimensions of HIV-related stigma that can compromise the mental and physical health of people living with HIV (PLWH). We focused on the dimension of experienced stigma, defined as exposure to acts of discrimination, devaluation, and prejudice, and investigated its relationship with HIV health and psychosocial outcomes. METHODS: We examined associations between experienced stigma in the community and healthcare settings and psychosocial and health outcomes for PLWH (N=203) receiving care at an urban HIV clinic in the Southeastern United States...
November 13, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29140857/that-s-inappropriate-social-norms-in-an-older-population-based-cohort
#14
Mary Ganguli, Zhaowen Sun, Eric McDade, Beth Snitz, Tiffany Hughes, Erin Jacobsen, Chung-Chou H Chang
BACKGROUND: Social cognition is not routinely assessed in older adults. We report population-based normative data on the Social Norms Questionnaire (SNQ22) which asks individuals about the appropriateness of specific behaviors in hypothetical scenarios, errors being related either to breaking with norms or to over-adhering to perceived norms. Total SNQ scores represent the number of correct responses while subscale scores are error totals. METHODS: We administered the SNQ22 to 744 adults aged 65+ within a population-based study, and examined the distribution of scores by demographics, other cognitive measures, and Clinical Dementia Rating (CDR)...
November 14, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29140831/relative-efficacies-of-hboc-201-and-polyheme-to-increase-oxygen-transport-compared-to-blood-and-crystalloids-2017-military-supplement
#15
Gregory P Dubé, Arkadiy N Pitman, Colin F Mackenzie
BACKGROUND: Because total hemoglobin in circulation ([THb]) is an established predictor of clinical outcomes in anemic individuals, the relative efficacies of resuscitation fluids to increase [THb] can be used to design better hemoglobin-based oxygen carrier (HBOC) clinical trials. METHODS: Expected efficacies of HBOC-201 (13 g Hb/dL) and packed RBCs (pRBCs, 24 g Hb/dL) to increase [THb] were calculated and interpreted in the context of SAEs in the HEM-0115 phase III clinical trial...
November 14, 2017: Shock
https://www.readbyqxmd.com/read/29140792/a-bayesian-hierarchical-model-for-identifying-significant-polygenic-effects-while-controlling-for-confounding-and-repeated-measures
#16
Christopher McMahan, James Baurley, William Bridges, Chase Joyner, Muhamad Fitra Kacamarga, Robert Lund, Carissa Pardamean, Bens Pardamean
Genomic studies of plants often seek to identify genetic factors associated with desirable traits. The process of evaluating genetic markers one by one (i.e. a marginal analysis) may not identify important polygenic and environmental effects. Further, confounding due to growing conditions/factors and genetic similarities among plant varieties may influence conclusions. When developing new plant varieties to optimize yield or thrive in future adverse conditions (e.g. flood, drought), scientists seek a complete understanding of how the factors influence desirable traits...
November 15, 2017: Statistical Applications in Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29140757/new-insights-into-lymphoma-pathogenesis
#17
Kojo S J Elenitoba-Johnson, Megan S Lim
Lymphomas represent clonal proliferations of lymphocytes that are broadly classified based upon their maturity (peripheral or mature versus precursor) and lineage (B cell, T cell, and natural killer cell). Insights into the pathogenetic mechanisms involved in lymphoma impact the classification of lymphoma and have significant implications for the diagnosis and clinical management of patients. Serial scientific and technologic advances over the last 30 years in immunology, cytogenetics, molecular biology, gene expression profiling, mass spectrometry-based proteomics, and, more recently, next-generation sequencing have contributed to greatly enhance our understanding of the pathogenetic mechanisms in lymphoma...
November 15, 2017: Annual Review of Pathology
https://www.readbyqxmd.com/read/29140756/cellular-and-molecular-mechanisms-of-autoimmune-hepatitis
#18
G J Webb, G M Hirschfield, E L Krawitt, M E Gershwin
Autoimmune hepatitis is an uncommon idiopathic syndrome of immunemediated destruction of hepatocytes, typically associated with autoantibodies. The disease etiology is incompletely understood but includes a clear association with human leukocyte antigen (HLA) variants and other non- HLA gene variants, female sex, and the environment. Pathologically, there is a CD4+ T cell-rich lymphocytic inflammatory infiltrate with variable hepatocyte necrosis and subsequent hepatic fibrosis. Attempts to understand pathogenesis are informed by several monogenetic syndromes that may include autoimmune liver injury, by several drug and environmental agents that have been identified as triggers in a minority of cases, by human studies that point toward a central role for CD4+ effector and regulatory T cells, and by animal models of the disease...
November 15, 2017: Annual Review of Pathology
https://www.readbyqxmd.com/read/29140741/comparative-in-vitro-study-of-11-c-methionine-and-11-c-deuterodeprenyl-uptake-in-three-human-glioma-cell-lines
#19
Elena Vasilskis, Ingrid Kreimerman, Silvia Olivera, Eduardo Savio, Henry Engler
AIM: To compare the uptake of (11)C-deuterodeprenyl ((11)C-DED) and (11)C-methionine ((11)C-MET) in three human glioma cell lines and study the relationship with glial fibrillary acid protein (GFAP) and monoamine oxidase B (MAO B) expression. (11)C-DED is used in positron emission tomography imaging as a marker of astrocytosis in various central nervous system pathologies. It binds irreversibly to MAO B, a glial dimeric enzyme with increased activity in some neurological pathologies. MATERIALS AND METHODS: Binding and internalization studies of (11)C-MET and (11)C-DED were performed in astrocytoma grade III, glioblastoma grade IV, and radio-resistant glioblastoma grade IV cells...
November 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29140738/do-outcomes-of-osteochondral-allograft-transplantation-differ-based-on-age-and-sex-a-comparative-matched-group-analysis
#20
Rachel M Frank, Eric J Cotter, Simon Lee, Sarah Poland, Brian J Cole
BACKGROUND: The effect of patient age or sex on outcomes after osteochondral allograft transplantation (OCA) has not been assessed. PURPOSE: To determine clinical outcomes for male and female patients aged ≥40 years undergoing OCA compared with a group of patients aged <40 years. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: A review of prospectively collected data of consecutive patients who underwent OCA by a single surgeon with a minimum follow-up of 2 years was conducted...
November 1, 2017: American Journal of Sports Medicine
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