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https://www.readbyqxmd.com/read/28333678/evaluation-of-the-antibacterial-activity-of-green-propolis-extract-and-meadowsweet-extract-against-staphylococcus-aureus-bacteria-importance-in-would-care-compounding-preparations
#1
Nogueira Rodrigo José Lupatini, Panagiota Danopoulos, Rosita Swikidisa, Pinheiro Vanessa Alves
The use of natural products in compounded wound care formulas is an exciting avenue to pursue for compounding pharmacists since these natural products may contain compounds that promote healing on their own. The use of these natural extracts as an alternative therapy for wound care may also provide several benefits, such as decreased inflammation, infection, side effects, and treatment costs. Thus far, several studies have demonstrated antimicrobial activity for various natural product extracts, including green propolis and meadowsweet...
July 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28330484/antibiotic-resistance-and-biofilm-production-among-the-strains-of-staphylococcus-aureus-isolated-from-pus-wound-swab-samples-in-a-tertiary-care-hospital-in-nepal
#2
Ankit Belbase, Narayan Dutt Pant, Krishus Nepal, Bibhusan Neupane, Rikesh Baidhya, Reena Baidya, Binod Lekhak
BACKGROUND: The increasing drug resistance along with inducible clindamycin resistance, methicillin resistance and biofilm production among the strains of Staphylococcus aureus are present as the serious problems to the successful treatment of the infections caused by S. aureus. So, the main objectives of this study were to determine the antimicrobial susceptibility patterns along with the rates of inducible clindamycin resistance, methicillin resistance and biofilm production among the strains of S...
March 23, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28290970/severe-systemic-lead-toxicity-resulting-from-extra-articular-retained-shrapnel-presenting-as-jaundice-and-hepatitis-a-case-report-and-review-of-the-literature
#3
Ian A Grasso, Matthew R Blattner, Tyler Short, John W Downs
INTRODUCTION: Despite greater than 60,000 nonfatal firearm injuries per year in the United States, retained shrapnel is a relatively rare cause of systemic lead toxicity with less than 100 cases reported in the medical literature since 1867. While intra-articular retained shrapnel as a cause of lead toxicity is well-described, extra-articular fragments are less well known to cause symptomatic disease. CASE REPORT: A 31-year-old man initially presented with abdominal pain, constipation, jaundice, and elevated liver transaminases approximately 3 weeks after suffering a left lower extremity injury during athletic activity...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28274096/effect-of-enhancers-on-in-vitro-and-in-vivo-skin-permeation-and-deposition-of-s-methyl-l-methionine
#4
Ki Taek Kim, Ji Su Kim, Min-Hwan Kim, Ju-Hwan Park, Jae-Young Lee, WooIn Lee, Kyung Kuk Min, Min Gyu Song, Choon-Young Choi, Won-Serk Kim, Hee Kyung Oh, Dae-Duk Kim
S-methyl-L-methionine (SMM), also known as vitamin U, is commercially available as skin care cosmetic products for its wound healing and photoprotective effects. However, the low skin permeation expected of SMM due to its hydrophilic nature with a log P value of -3.3, has not been thoroughly addressed. The purpose of this study thus was to evaluate the effect of skin permeation enhancers on the skin permeation/deposition of SMM. Among the enhancers tested for the in vitro skin permeation and deposition of SMM, oleic acid showed the most significant enhancing effect...
March 10, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28272011/human-reticular-acellular-dermal-matrix-in-the-healing-of-chronic-diabetic-foot-ulcerations-that-failed-standard-conservative-treatment-a-retrospective-crossover-study
#5
Charles M Zelen, Dennis P Orgill, Thomas E Serena, Robert D Galiano, Marissa J Carter, Lawrence A DiDomenico, Jarrod P Kaufman, Jennifer Keller, Nathan J Young, William W Li
BACKGROUND: Acellular matrices have been successfully used to heal indolent diabetic foot ulcers (DFUs). These tissues include allogenic dermis as well as xenograft dermis, pericardium, and small intestine submucosa. While all of these tissues show promise for healing DFUs, dermal-derived matrices have shown considerable potential. MATERIALS AND METHODS: The authors retrospectively reviewed healing in patients with DFUs that failed the standard of care (SOC) treatment from a previous prospective randomized, controlled trial (RCT)...
February 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28272010/the-use-of-a-sea-salt-based-spray-for-diabetic-foot-ulcers-a-novel-concept
#6
David A Pougatsch, Andrew Rader, Lee C Rogers
Several patients present to wound healing specialists seeking a natural or alternative medical approach to their wounds. The purpose of this prospective, case-cohort study of 10 patients was to evaluate the use of Oceanzyme Wound Care Spray (Ocean Aid, Inc, Boynton Beach, FL) in improving healing in diabetic foot ulcers during a 12-week period. This product contains water purified by reverse osmosis, coral reef sea salt, lysozyme, and sodium benzoate. The primary endpoint was wound closure, and secondary endpoints were infection rate and wound area reduction...
February 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28271816/an-overview-on-application-of-natural-substances-incorporated-with-electrospun-nanofibrous-scaffolds-to-development-of-innovative-wound-dressings
#7
Nosratollah Zarghami, Roghayeh Sheervalilou, Amir Fattahi, Abbas Mohajeri, Mehdi Dadashpour, Younes Pilehvar-Soltanahmadi
Conventional dressings are cost-effective and highly absorbent, but not effectual enough to promote hemostasis, adherence and in holding a moist wound bed. Thanks to the developments in the field of nanotechnology and bioengineering, one of the promising current trends is to move progress of innovative wound dressings, merging the application of traditional healing agents and modern products/practices, such as hydrocolloids, hydrogels, films and nanofibers. The electrospun nanofibers webs can provide the essential parameters require for wound dressing to heal wounds including absorptivity, oxygen permeability, and non-adherence to the healing tissue, barrier to bacteria, bioactivity and occlusivity...
March 8, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28267128/medical-adhesive-related-skin-injury-following-emergent-appendectomy-a-case-study-of-marsi-and-missed-opportunities-in-nursing-care
#8
Sylvia E Britt, Karen M Coles, Shannon S Polson
BACKGROUND: The potential for skin damage from adhesive products is documented in the literature. Nevertheless, health care providers continue to lack understanding of the impact and seriousness of skin injury associated with use of tapes or other adhesive devices when applied to a patient with a history or hypersensitivity or allergy to adhesives. CASE: A 67-year-old woman with a history of tape allergy underwent emergency appendectomy. Initial removal of an adhesive bandage placed over the surgical incision revealed medical adhesive-related skin injury (MARSI)...
March 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28254279/impact-of-matrix-stiffness-on-fibroblast-function
#9
Hichem El-Mohri, Yang Wu, Swetaparna Mohanty, Gargi Ghosh
Chronic non-healing wounds, caused by impaired production of growth factors and reduced vascularization, represent a significant burden to patients, health care professionals, and health care system. While several wound dressing biomaterials have been developed, the impact of the mechanical properties of the dressings on the residing cells and consequently on the healing of the wounds is largely overlooked. The primary focus of this study is to explore whether manipulation of the substrate mechanics can regulate the function of fibroblasts, particularly in the context of their angiogenic activity...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28242666/adjuvant-antibiotic-activity-of-acidic-sophorolipids-with-potential-for-facilitating-wound-healing
#10
Helen L Lydon, Niki Baccile, Breedge Callaghan, Roger Marchant, Christopher A Mitchell, Ibrahim M Banat
The sophorolipid class of biosurfactants are finding increasing use in personal care as well as pharmaceutical products and have the potential to disrupt biofilm formation and inhibit growth in a variety of clinically relevant organisms. In order to investigate potential biomedical applications of sophorolipids derived from non-pathogenic organisms, we fractionated and purified glycolipid biosurfactant sophorolipids produced by the yeast Starmerella bombicola, which yielded both acidic C 18-1 acetylated and non-acetylated congeners that were essentially free from other contaminants (>95% purity)...
February 27, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28241824/treatment-of-chronic-non-healing-ulcers-using-autologous-platelet-rich-plasma-a-case-series
#11
Manish Suthar, Saniya Gupta, Suhail Bukhari, Venkatesh Ponemone
BACKGROUND: Non-healing ulcers are a major health problem worldwide and have great impact at personal, professional and social levels, with high cost in terms of human and material resources. Recalcitrant non-healing ulcers are inevitable and detrimental to the lower limb and are a major cause of non-traumatic lower limb amputations. Application of autologous Platelet Rich Plasma (PRP) has been a major breakthrough for the treatment of non-healing and diabetic foot ulcers, as it is an easy and cost-effective method, and provides the necessary growth factors that enhance tissue healing...
February 27, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28154581/detection-of-methicillin-resistant-staphylococcus-aureus-and-determination-of-minimum-inhibitory-concentration-of-vancomycin-for-staphylococcus-aureus-isolated-from-pus-wound-swab-samples-of-the-patients-attending-a-tertiary-care-hospital-in-kathmandu-nepal
#12
Raghabendra Adhikari, Narayan Dutt Pant, Sanjeev Neupane, Mukesh Neupane, Roshan Bhattarai, Sabita Bhatta, Raina Chaudhary, Binod Lekhak
The present study was conducted to evaluate the performance of cefoxitin disc diffusion method and oxacillin broth microdilution method for detection of methicillin resistant S. aureus (MRSA), taking presence of mecA gene as reference. In addition, inducible clindamycin resistance and beta-lactamase production were studied and minimum inhibitory concentration (MIC) of vancomycin for S. aureus isolates was determined. A total of 711 nonrepeated pus/wound swab samples from different anatomic locations were included in the study...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/28129780/manubrium-limited-ministernotomy-versus-conventional-sternotomy-for-aortic-valve-replacement-mavric-study-protocol-for-a-randomised-controlled-trial
#13
Enoch Akowuah, Andrew T Goodwin, W Andrew Owens, Helen C Hancock, Rebecca Maier, Adetayo Kasim, Adrian Mellor, Khalid Khan, Gavin Murphy, James Mason
BACKGROUND: Aortic valve replacement is one of the most common cardiac surgical procedures performed worldwide. Conventional aortic valve replacement surgery is performed via a median sternotomy; the sternum is divided completely from the sternal notch to the xiphisternum. Minimally invasive aortic valve replacement, using a new technique called manubrium-limited ministernotomy, divides only the manubrium from the sternal notch to 1 cm below the manubrio-sternal junction. More than one third of patients undergoing conventional sternotomy develop clinically significant bleeding requiring post-operative red blood cell transfusion...
January 28, 2017: Trials
https://www.readbyqxmd.com/read/28060000/embracing-the-concept-defining-the-practice-and-changing-the-outcome-setting-the-standard-for-medical-adhesive-related-skin-injury-interventions-in-woc-nursing-practice
#14
Stephanie Yates, Laurie McNichol, Steven B Heinecke, Mikel Gray
Medical adhesive-related skin injury (MARSI) is a comparatively new category of skin damage. Our current understanding of MARSI originates from an interdisciplinary consensus conference held in 2012 that generated and disseminated 25 statements pertaining to the assessment, prevention, and management of MARSI, along with gaps in research and knowledge related to this area. The 2012 MARSI Consensus Group also challenged each organization to refine the original statements to make them more relevant to their particular area of practice...
January 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28050503/the-oro-facial-investment-scale-ofis-a-novel-outcomes-and-evaluation-measure-for-self-appraised-oro-facial-behavioural-and-aesthetic-constructs-among-professional-healthcare-students-of-belagavi-a-cross-sectional-study
#15
Vaibhav Kumar, Anil V Ankola, Sagar G Jalihal
INTRODUCTION: Several studies have shown that self perceived dental appearance is an important determinant in the decision to seek treatment. AIM: The aim of the present study was to assess the self-perceived oral health knowledge, attitude, practice, behaviour and perception among 18-20 year old students of professional healthcare institutions in Belagavi city, Karnataka. MATERIALS AND METHODS: The novel 21 item Oro-Facial Investment Scale (OFIS) formulated for this study was distributed to 600 students of professional healthcare institutions (200 each from Medical, Physiotherapy and Ayurveda specialties respectively)...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28030589/the-antibacterial-activity-of-australian-leptospermum-honey-correlates-with-methylglyoxal-levels
#16
Nural N Cokcetin, Matthew Pappalardo, Leona T Campbell, Peter Brooks, Dee A Carter, Shona E Blair, Elizabeth J Harry
Most commercially available therapeutic honey is derived from flowering Leptospermum scoparium (manuka) plants from New Zealand. Australia has more than 80 Leptospermum species, and limited research to date has found at least some produce honey with high non-peroxide antibacterial activity (NPA) similar to New Zealand manuka, suggesting Australia may have a ready supply of medical-grade honey. The activity of manuka honey is largely due to the presence of methylglyoxal (MGO), which is produced non-enzymatically from dihydroxyacetone (DHA) present in manuka nectar...
2016: PloS One
https://www.readbyqxmd.com/read/27997744/a-comparative-outcomes-analysis-evaluating-clinical-effectiveness-in-two-different-human-placental-membrane-products-for-wound-management
#17
Eric L Johnson, James T Marshall, Georgina M Michael
Advances in tissue preservation have led to the commercialization of human placental membranes for the purposes of wound management with each product being characterized by different compositions and properties. The a priori specification of the research question in this investigator-initiated study focused on the clinical outcomes in two nonrandomized, however statistically equal and homogenous patient cohorts receiving either a viable intact cryopreserved human placental membrane (vCPM) or a dehydrated human amnion/chorion membrane (dHACM), for the management of wounds at a single center...
December 20, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27992134/compression-therapy-current-practice-of-care-level-of-knowledge-in-patients-with-venous-leg-ulcers
#18
Kerstin Protz, Kristina Heyer, Joachim Dissemond, Barbara Temme, Karl-Christian Münter, Ida Verheyen-Cronau, Katharina Klose, Carsten Hampel-Kalthoff, Matthias Augustin
BACKGROUND AND OBJECTIVES: Compression therapy is a mainstay in the causal treatment of patients with venous leg ulcers. It facilitates healing, reduces pain and recurrences, and increases quality of life. Up until now, there is a scarcity of scientific data with respect to the level of care and the specific knowledge of patients with venous leg ulcers. PATIENTS AND METHODS: At first presentation, patients with venous leg ulcers anonymously answered a standardized questionnaire...
December 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27979363/-aplasia-cutis-congenita-associated-with-epidermolysis-bullosa
#19
Félix Muñoz-Guerrero, Adrián Antonio Muñoz-Solís, José Manuel Ornelas-Aguirre
INTRODUCTION: Aplasia cutis congenita (ACC) is a skin condition of rare presentation, this disease is characterized by absence of skin at birth and associated with facial, skin and bone skull deformities. The diagnosis is mainly clinical. CASE REPORT: Male 5 days after birth, unique product of primigravida mother and no family history of relevance. Physical examination revealed bilateral and symmetrical skin defects of both lower extremities, the disease is characterized by skin fragility, scabs, and coated pseudomembrane ulcers, decreased interdigital space between toes of the left foot, retraction of the foot and genu varum...
December 12, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/27977053/protease-modulating-matrix-treatments-for-healing-venous-leg-ulcers
#20
REVIEW
Maggie J Westby, Gill Norman, Jo C Dumville, Nikki Stubbs, Nicky Cullum
BACKGROUND: Venous leg ulcers (VLUs) are open skin wounds on the lower leg that occur because of poor blood flow in the veins of the leg; leg ulcers can last from weeks to years, and are both painful and costly. Prevalence in the UK is about 2.9 cases per 10,000 people. First-line treatment for VLUs is compression therapy, but around 60% of people have unhealed ulcers after 12 weeks' treatment and about 40% after 24 weeks; therefore, there is scope for further improvement. Limited evidence suggests non-healing leg ulcers may have persisting elevated levels of proteases, which is thought to deter the later stages of healing; thus, timely protease-modulating matrix (PMM) treatments may improve healing by physically removing proteases from the wound fluid...
December 15, 2016: Cochrane Database of Systematic Reviews
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