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https://www.readbyqxmd.com/read/28810801/may-dietary-supplementation-augment-respiratory-burst-in-wound-site-inflammatory-cells
#1
Amitava Das, Ryan Dickerson, Piya Das Ghatak, Gayle Gordillo, Scott Chaffee, Abhijoy Saha, Savita Khanna, Sashwati Roy
Persistent infection contributes to wound chronicity. At the wound-site, NADPH oxidase activity in immune cells fights infection to enable the healing process. Fermented Papaya Preparation (FPP) is a carbohydrate-rich nutritional supplement that has demonstrated ability to bolster respiratory burst in experimental rodent systems. In FPP, glucose co-exists with fructose and maltose in addition to multiple other sugar alcohols such as inositol. We have previously reported that FPP supplementation augments wound healing in diabetic mice via improvement of respiratory-burst activity of wound innate immune cells...
August 16, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28805478/production-of-platelet-rich-plasma-gel-from-elderly-patients-under-antithrombotic-drugs-perspectives-in-chronic-wounds-care
#2
M Velier, J Magalon, A Daumas, M Cassar, P Francois, A Ghazouane, C Philandrianos, B Bertrand, C Frere, D Bernot, P Villani, F Dignat George, F Sabatier
Platelet-Rich Plasma (PRP) is an autologous biological therapy obtained by centrifuging the patient's own blood to concentrate platelets. The addition of autologous thrombin and calcium chloride to PRP allows the production of a semi-solid form called PRP gel. PRP gel is increasingly used in a variety of tissue defects and predominantly in the management of non-healing chronic wounds. The topical application of PRP gel seems promising due to the capability of platelets to store and secrete growth factors (GF), fibrin and cytokines, which are essentials for wound healing...
August 14, 2017: Platelets
https://www.readbyqxmd.com/read/28801082/-how-to-videos-improve-residents-performance-of-essential-perioperative-electronic-medical-records-and-clinical-tasks
#3
Veronica Zoghbi, Robert C Caskey, Kristoffel R Dumon, Jacqueline M Soegaard Ballester, Ari D Brooks, Jon B Morris, Daniel T Dempsey
OBJECTIVE: The ability to use electronic medical records (EMR) is an essential skill for surgical residents. However, frustration and anxiety surrounding EMR tasks may detract from clinical performance. We created a series of brief, 1-3 minutes "how to" videos demonstrating 7 key perioperative EMR tasks: booking OR cases, placing preprocedure orders, ordering negative-pressure wound dressing supplies, updating day-of-surgery history and physical notes, writing brief operative notes, discharging patients from the postanesthesia care unit, and checking vital signs...
August 8, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28795881/understanding-biofilm-in-practice-a-global-survey-of-health-professionals
#4
T Swanson, R D Wolcott, H Wallis, E J Woodmansey
OBJECTIVE: The aim of this survey was to examine health professionals' views and practices relating to biofilm in chronic wounds. METHOD: A global online survey was conducted to assess the current understanding of biofilm and wound management practices. The survey consisted of 20 questions designed to evaluate health professional knowledge of biofilm, perception and understanding of biofilm behaviour, detection and diagnosis, and treatment. Respondents were classified as 'specialists' if wounds were their primary focus and they developed protocols and determined formularies...
August 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28782223/how-and-why-patients-self-treat-chronic-wounds
#5
Suzanne Kapp, Nick Santamaria
The aim of this study was to investigate how people self-treat chronic wounds, why they self-treat and the assistance and support that they receive. The increasing emphasis on self-management of chronic conditions, the potential benefits of self-treatment to the health care consumer and competing demands on health care funding are good reasons to investigate self-treatment of chronic wounds as we have little data on this group of individuals. A survey study was conducted in Australia. A non-random sample of 100 participants was recruited...
August 6, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28777906/can-amputation-be-prevented-in-diabetic-foot-interdisciplinary-approach-to-diabetic-foot-a-case-report
#6
Ali Erdal Gunes, Maide Cimsit
Diabetic foot ulcers may result in loss of an extremity and may even lead to mortality. The use of comprehensive foot care programs which include early screening and evaluation of problems, foot care education, preventive therapy and referral to specialists has been shown to reduce amputation rates by 49-85 [percent]. A 51-year-old woman with Type 2 diabetes under surveillance for nine months was referred from the emergency department. She presented with an entirely inflamed right foot with ulcer covering two-thirds proximal of the foot for 30 days' duration...
March 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/28756628/harnessing-electronic-healthcare-data-for-wound-care-research-wound-registry-analytic-guidelines-for-less-biased-analyses
#7
Marissa J Carter
Publications based on large healthcare databases that contain data pertaining to wound-related outcomes are starting to appear more frequently. However, concern exists in regard to study design adequacy, the methodology used to minimize misclassifications, bias, and confounding, and lack of full reporting. The STROBE guidelines were published to encourage fuller reporting of observational studies and have now been extended using the RECORD statement to better document routinely collected healthcare data. In this paper, elements of the RECORD statement have been used to create guidelines for study design, cohort matching, reporting criteria, and analysis frameworks in regard to analyses of populations involving comparative effectiveness research...
July 29, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28750102/stability-of-bacteriophages-in-burn-wound-care-products
#8
Maia Merabishvili, Riet Monserez, Jonas van Belleghem, Thomas Rose, Serge Jennes, Daniel De Vos, Gilbert Verbeken, Mario Vaneechoutte, Jean-Paul Pirnay
Bacteriophages could be used along with burn wound care products to enhance antimicrobial pressure during treatment. However, some of the components of the topical antimicrobials that are traditionally used for the prevention and treatment of burn wound infection might affect the activity of phages. Therefore, it is imperative to determine the counteraction of therapeutic phage preparations by burn wound care products before application in patients. Five phages, representatives of two morphological families (Myoviridae and Podoviridae) and active against 3 common bacterial burn wound pathogens (Acinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureus) were tested against 13 different products commonly used in the treatment of burn wounds...
2017: PloS One
https://www.readbyqxmd.com/read/28729228/tangled-history-of-the-european-uses-of-sphagnum-moss-and-sphagnol
#9
REVIEW
Jacek Drobnik, Adam Stebel
ETHNOPHARMACOLOGICAL RELEVANCE: Sphagnum mosses and peat could have been utilized as wound dressings for centuries, however reliable data on this subject are ambiguous; sometimes even no distinction between peat moss (Sphagnum spp.) and peat is made or these terms become confused. The first scientific account on surgical use of peat comes from 1882: a peat digger who successfully, by himself and in the way unknown to the then medicine, cured an open fracture of his forearm with peat. The peat, and very soon the peat moss itself (which is the major constituent of peat) drew attention of the 19th-century surgeons...
July 18, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28697050/transfusion-requirement-in-burn-care-evaluation-tribe-a-multicenter-randomized-prospective-trial-of-blood-transfusion-in-major-burn-injury
#10
Tina L Palmieri, James H Holmes, Brett Arnoldo, Michael Peck, Bruce Potenza, Amalia Cochran, Booker T King, William Dominic, Robert Cartotto, Dhaval Bhavsar, Nathan Kemalyan, Edward Tredget, Francois Stapelberg, David Mozingo, Bruce Friedman, David G Greenhalgh, Sandra L Taylor, Brad H Pollock
OBJECTIVE: Our objective was to compare outcomes of a restrictive to a liberal red cell transfusion strategy in 20% or more total body surface area (TBSA) burn patients. We hypothesized that the restrictive group would have less blood stream infection (BSI), organ dysfunction, and mortality. BACKGROUND: Patients with major burns have major (>1 blood volume) transfusion requirements. Studies suggest that a restrictive blood transfusion strategy is equivalent to a liberal strategy...
July 10, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28682855/management-of-a-complex-peristomal-calciphylaxis-a-case-study
#11
Mary Famorca, Debra Beauchaine, Nancy Angulo
BACKGROUND: Calciphylaxis, also referred to as calcific uremic arteriolopathy, is a rare and serious syndrome of small blood vessels with a high mortality rate. Calciphylaxis lesions require intensive wound management with medical interventions for the patient to survive the sequelae of sepsis and present unique challenges when found in the peristomal skin. CASE: A 33-year-old man presented with multiple malodorous stage 4 pressure injuries of his sacrococcygeal and gluteal area...
July 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28682677/randomized-controlled-trial-of-polyhexanide-betaine-gel-versus-silver-sulfadiazine-for-partial-thickness-burn-treatment
#12
Saruta Wattanaploy, Kusuma Chinaroonchai, Nantaporn Namviriyachote, Pornprom Muangman
Silver sulfadiazine is commonly used in the treatment of partial-thickness burns, but it sometimes forms pseudo-eschar and delays wound healing. Polyhexanide/betaine gel, a new wound cleansing and moisturizing product, has some advantages in removing biofilm and promotes wound healing. This study was designed to compare clinical efficacy of polyhexanide/betaine gel with silver sulfadiazine in partial-thickness burn treatment. From September 2013 to May 2015, 46 adult patients with partial-thickness burn ≥10% total body surface area that were admitted to the Burn Unit of Siriraj Hospital within 48 hours after injury were randomly allocated into 2 groups...
March 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28669821/diet-enrichment-with-a-specific-essential-free-amino-acid-mixture-improves-healing-of-undressed-wounds-in-aged-rats
#13
Giovanni Corsetti, Claudia Romano, Evasio Pasini, Emanuele Marzetti, Riccardo Calvani, Anna Picca, Vincenzo Flati, Francesco S Dioguardi
Chronic wounds are a major, often underestimated, health problem for the elderly. Standard wound care products are not usually manufactured to meet the increased demand of nutrients by skin cells in order to regenerate new tissue and accelerate healing. This work was therefore undertaken to establish whether wound healing could be accelerated by nutritional supplementation with a specific mixture tailored to human need of essential amino acids (EAAs) without topical medication. To this end, using a skin full-thickness excisional model in aged rats, we compared the closure dynamics of undressing wounds in animals fed an EAAs-enriched diet or standard diet...
June 29, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28645493/sprayable-carbopol-hydrogel-with-soluble-beta-1-3-1-6-glucan-as-an-active-ingredient-for-wound-healing-development-and-in-vivo-evaluation
#14
Jostein Grip, Rolf Einar Engstad, Ingrid Skjæveland, Nataša Škalko-Basnet, Ann Mari Holsæter
Chronic wounds represent a significant health problem worldwide. There is a need for advanced- and cost-efficient wound healing products able to increase patient comfort and reduce the healing time. The aim of this study was to develop a sprayable hydrogel dressing with beta-glucan (βG) as the active ingredient, targeting future application in the treatment of both chronic and burn wounds. The βG was chosen as an active ingredient because of its promising wound healing capabilities, whereas Carbopol 971P NF (Carbopol) was chosen as the thickening agent in the formulation due to several attractive characteristics such as its low viscosity, low toxicity, high transparency and good ion tolerance...
June 21, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28635188/the-financial-and-quality-of-life-cost-to-patients-living-with-a-chronic-wound-in-the-community
#15
Suzanne Kapp, Nick Santamaria
Chronic wounds are associated with financial and personal costs. The system level expense associated with chronic wounds has been established, however, the out-of-pocket cost incurred by individuals who self-fund has not been the focus of extensive investigation. Recently, there has been renewed interest in evaluating quality of life, in line with the shift to patient enablement and self-care in chronic disease management. The objectives of this research were to describe the out-of-pocket wound treatment costs and the quality of life of people who have chronic wounds...
June 20, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28633147/tranexamic-acid-safely-reduced-blood-loss-in-hemi-and-total-hip-arthroplasty-for-acute-femoral-neck-fracture-a-randomized-clinical-trial
#16
Chad D Watts, Matthew T Houdek, S Andrew Sems, William W Cross, Mark W Pagnano
OBJECTIVES: We aimed to determine whether (1) tranexamic acid (TXA) reduces the incidence of transfusion (2) TXA reduces the calculated blood loss, and (3) there are any observable differences in 30- and 90-day complications with TXA administration during arthroplasty for femoral neck fracture (FNF). DESIGN: Prospective, double-blinded, randomized controlled trial. SETTING: Level 1 Academic Trauma Center. PATIENTS/PARTICIPANTS: One hundred thirty-eight patients who presented with a low-energy, isolated, FNF (AO 31B) treated with either hemi- or total hip arthroplasty within 72 hours of injury were randomized to either the TXA group (69 patients) or placebo group (69 patients)...
July 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28624002/pathophysiology-of-venous-ulceration
#17
REVIEW
Joel M Crawford, Brajesh K Lal, Walter N Durán, Peter J Pappas
Our understanding of the pathophysiologic process of venous ulceration has dramatically increased during the past two decades because of dedicated, venous-specific basic science research. Currently, the mechanisms regulating venous ulceration are a combination of macroscopic and microscopic pathologic processes. Macroscopic alterations refer to pathologic processes related to varicose vein formation, vein wall architecture, and cellular abnormalities that impair venous function. These processes are primarily caused by genetic factors that lead to the destruction of normal vein wall architecture and venous hypertension...
July 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28604548/pediatric-lower-extremity-lawn-mower-injuries-and-reconstruction-retrospective-10-year-review-at-a-level-1-trauma-center
#18
Leslie G Branch, John C Crantford, James T Thompson, Shruti C Tannan
INTRODUCTION: From 2004 to 2013, there were 9341 lawn mower injuries in children under 20 years old. The incidence of lawn mower injuries in children has not decreased since 1990 despite implementation of various different prevention strategies. In this report, the authors review the results of pediatric lawn mower-related lower-extremity injuries treated at a tertiary care referral center as well as review the overall literature. METHODS: A retrospective review was performed at a level 1 trauma center over a 10-year period (2005-2015)...
June 9, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28600506/antibacterial-cellulose-paper-made-with-silver-coated-gold-nanoparticles
#19
Tsung-Ting Tsai, Tse-Hao Huang, Chih-Jung Chang, Natalie Yi-Ju Ho, Yu-Ting Tseng, Chien-Fu Chen
In this study, we investigated the antibacterial activity of silver-coated gold nanoparticles (Au-Ag NPs) immobilized on cellulose paper. Ag NPs are known to have strong antibacterial properties, while Au NPs are biocompatible and relatively simple to prepare. We made the Au-Ag NPs using a facile process called Ag enhancement, in which Au NPs serve as the nuclei for precipitation of a Ag coating, the thickness of which can be easily controlled by varying the ratio of the reactants. After synthesis, electron microscopy showed that the Au-Ag NPs displayed a core-shell structure, and that they could be successfully immobilized onto a cellulose membrane by heat treatment...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28570251/comparative-clinical-study-of-the-wound-healing-effects-of-a-novel-micropore-particle-technology-effects-on-wounds-venous-leg-ulcers-and-diabetic-foot-ulcers
#20
Olga O Bilyayeva, Viacheslav V Neshta, Alexander A Golub, Frank Sams-Dood
OBJECTIVE: The purpose of this study was to determine the wound healing effects of Acapsil, a white, odorless powder based on micropore particle technology (MPPT) (Willingsford Ltd, Southampton, UK) by comparing it to Gentaxane (Gentaksan, Borshchagovsky CCP, Kyiv, Ukraine) (polydimethylsiloxane powder with gentamicin antibiotic) and Ioddicerin (Farmak, Kyiv, Ukraine) (iodine with dimethyl sulfoxide [DMSO]). MATERIALS AND METHODS: The study included 266 patients with primarily trophic ulcers caused by pancreatic diabetes and venous insufficiency of the lower extremities, carbuncles, phlegmons, infected third- or fourth-degree heat burns, and infiltrations of postoperative wounds...
May 25, 2017: Wounds: a Compendium of Clinical Research and Practice
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