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https://www.readbyqxmd.com/read/29324426/a-sweet-solution-the-use-of-medical-grade-honey-on-oral-mucositis-in-the-pediatric-oncology-patient
#1
Ferne T Elsass
INTRODUCTION: Pediatric patients develop mucositis when receiving treatments such as chemotherapy and radiation; the most common and sensitive is oral mucositis. Mouth rinses containing antimicrobial, antihistamine, and analgesic medications are the mainstay for pediatric patients; however, patients often refuse these rinses due to the taste or texture. Also, patients under 1 year of age are unable to use these products. OBJECTIVE: Herein, the improvement of oral mucositis with standard oral care and additional use of active Leptospermum honey in pediatric oncology patients after chemotherapy is demonstrated...
December 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29320588/a-guide-to-tissue-engineered-skin-substitutes
#2
Penelope J Kallis, Adam J Friedman, Hadar Lev-Tov
<p>Wounds that exhibit delayed healing have a tremendous impact on health care expenditures and place patients at serious risk for severe complications including death. The healing of a chronic wound requires the restoration of multiple factors that normally work in concert to repair the damaged skin barrier. Skin substitutes have shown great promise for use as adjunctive therapies for refractory wounds by providing cells, soluble mediators, and extracellular matrix materials needed to stimulate healing...
January 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29245303/viable-placental-allograft-as-a-biological-dressing-in-the-clinical-management-of-full-thickness-thermal-occupational-burns-two-case-reports
#3
Eric L Johnson, Elisabet K Tassis, Georgina M Michael, Susan G Whittinghill
RATIONALE: Occupational burn injuries can be detrimental and difficult to manage. The majority of complex cases are referred and managed at regional burn centers where access to specialized care is available. As an alternative to hospitalization with staged surgical procedures, placental products may be used for outpatient medical management of these common burn injuries, especially if access to a regional burn center is limited or restricted.Fresh amnion has been a treatment of choice in burns for more than 100 years...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29244969/treatment-of-open-upper-limb-injuries-with-infection-prevention-and-negative-pressure-wound-therapy-a-systematic-review
#4
E Ali, M Raghuvanshi
OBJECTIVE: Open upper limb injuries requiring soft reconstruction can pose a dilemma for trauma surgeons when considering the treatment options. The British Orthopaedic Association and British Association of Plastic, Reconstructive and Aesthetic Surgeons Standard for Trauma (BOAST) have addressed the management of severe open lower limb fractures with the creation of the BOAST 4 guidelines. However, no such gold standard exists for the treatment of open injuries of the upper limb. Furthermore, treatment of these injuries is often more difficult and requires complicated strategies...
December 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29240589/infrared-skin-thermometry-validating-and-comparing-techniques-to-detect-periwound-skin-infection
#5
Asfandyar Mufti, Ranjani Somayaji, Patricia Coutts, R Gary Sibbald
OBJECTIVE: Diagnosis of wound infection can be challenging because it relies on a combination of clinical signs and symptoms that are often nonspecific. Increased periwound cutaneous temperature is a classic sign of deep and surrounding wound infection, and its quantitative measurement is one of the most reliable and valid clinical signs of deep and surrounding skin infection at the bedside. Skin surface temperature differences may be detected using commercially available noncontact infrared thermometers...
January 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29236557/complications-and-posttreatment-care-following-invasive-laser-skin-resurfacing-a-review
#6
Dan Li, Shi-Bin Lin, Biao Cheng
OBJECTIVE: Laser skin resurfacing (LSR) has been used for facial rejuvenation for the last 20 years. Posttreatment care after LSR is essential to decrease the risk of complications. Currently, no unified standards or criteria exist for invasive LSR posttreatment care. We aimed to identify the optimal wound care timing and choice of specific local, systemic, and general medical measures required to decrease complications. METHODS: We performed a systematic search of the PubMed/MEDLINE electronic databases and included only articles written and published in the English language, with no restrictions on the publication time (year)...
December 13, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29232903/pediatric-thermal-burns-and-treatment-a-review-of-progress-and-future-prospects
#7
REVIEW
Elton Mathias, Madhu Srinivas Murthy
Burn injuries are a devastating critical care problem. In children, burns continue to be a major epidemiologic problem around the globe resulting in significant morbidity and death. Apparently, treating these burn injuries in children and adults remains similar, but there are significant physiological and psychological differences. The dermal layer of the skin is generally thinner in neonates, infants, and children than in adults. Enhanced evaporative loss and need for isotonic fluids increases the risk of hypothermia in the pediatric population...
December 11, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29219944/minimally-invasive-surgical-pulmonary-embolectomy-a-potential-alternative-to-conventional-sternotomy
#8
Chetan Pasrija, Aakash Shah, Elliot Sultanik, Michael Rouse, Mehrdad Ghoreishi, Gregory J Bittle, Francesca Boulos, Bartley P Griffith, Zachary N Kon
OBJECTIVE: Surgical pulmonary embolectomy has gained increasing popularity over the past decade with multiple series reporting excellent outcomes in the treatment of submassive pulmonary embolism. However, a significant barrier to the broader adoption of surgical pulmonary embolectomy remains the large incision and long recovery after a full sternotomy. We report the safety and efficacy of using a minimally invasive approach to surgical pulmonary embolectomy. METHODS: All consecutive patients undergoing surgical pulmonary embolectomy for a submassive pulmonary embolism (2015-2017) were reviewed...
November 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29209583/what-makes-the-optimal-wound-healing-material-a-review-of-current-science-and-introduction-of-a-synthetic-nanofabricated-wound-care-scaffold
#9
REVIEW
Matthew R MacEwan, Sarah MacEwan, Tamas R Kovacs, Joel Batts
Wound matrix materials are used to improve the regeneration of dermal and epidermal layers in both acute and chronic wounds. Contemporary wound matrices are primarily composed of biologic materials such as processed xenogeneic and allogeneic tissues. Unfortunately, existing biologic wound matrices possess multiple limitations including poor longevity, durability, strength, and enzymatic resistance required for persistent support for new tissue formation. A fully-synthetic, resorbable electrospun material (Restrata Wound Matrix, Acera, St...
October 2, 2017: Curēus
https://www.readbyqxmd.com/read/29206884/rapid-research-and-implementation-priority-setting-for-wound-care-uncertainties
#10
Trish A Gray, Jo C Dumville, Janice Christie, Nicky A Cullum
INTRODUCTION: People with complex wounds are more likely to be elderly, living with multimorbidity and wound related symptoms. A variety of products are available for managing complex wounds and a range of healthcare professionals are involved in wound care, yet there is a lack of good evidence to guide practice and services. These factors create uncertainty for those who deliver and those who manage wound care. Formal priority setting for research and implementation topics is needed to more accurately target the gaps in treatment and services...
2017: PloS One
https://www.readbyqxmd.com/read/29193735/shotgun-label-free-proteomic-analysis-for-identification-of-proteins-in-hacat-human-skin-keratinocytes-regulated-by-the-administration-of-collagen-from-soft-shelled-turtle
#11
Tetsushi Yamamoto, Saori Nakanishi, Kuniko Mitamura, Atsushi Taga
Soft-shelled turtles (Pelodiscus sinensis) are widely distributed in some Asian countries, and we previously reported that soft-shelled turtle tissue could be a useful material for collagen. In the present study, we performed shotgun liquid chromatography (LC)/mass spectrometry (MS)-based global proteomic analysis of collagen-administered human keratinocytes to examine the functional effects of collagen from soft-shelled turtle on human skin. Using a semiquantitative method based on spectral counting, we were able to successfully identify 187 proteins with expression levels that were changed more than twofold by the administration of collagen from soft-shelled turtle...
November 28, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29182584/adjuvant-biological-therapies-in-chronic-leg-ulcers
#12
REVIEW
Natalia Burgos-Alonso, Igone Lobato, Igone Hernández, Kepa San Sebastian, Begoña Rodríguez, Gontzal Grandes, Isabel Andia
Current biological treatments for non-healing wounds aim to address the common deviations in healing mechanisms, mainly inflammation, inadequate angiogenesis and reduced synthesis of extracellular matrix. In this context, regenerative medicine strategies, i.e., platelet rich plasmas and mesenchymal stromal cell products, may form part of adjuvant interventions in an integral patient management. We synthesized the clinical experience on ulcer management using these two categories of biological adjuvants. The results of ten controlled trials that are included in this systematic review favor the use of mesenchymal stromal cell based-adjuvants for impaired wound healing, but the number and quality of studies is moderate-low and are complicated by the diversity of biological products...
November 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29153063/-investigation-of-various-virulence-factors-of-klebsiella-pneumoniae-strains-isolated-from-nosocomial-infections
#13
Halit Kuş, Uğur Arslan, Hatice Türk Dağı, Duygu Fındık
Klebsiella pneumoniae is an opportunistic pathogen that commonly affects immunosuppressed patients and causes nosocomial infections. K.pneumoniae has a variety of virulence factors, especially capsule polysaccharide, hypermucoviscosity (HV), fimbriae, toxins and determinants for iron acquisition. The aim of this study was to detect the virulence factors in K.pneumoniae strains isolated from nosocomial infections in two years. Fifty three K.pneumoniae strains isolated from the samples of patients with nosocomial infections in the Medical Microbiology Laboratory of Selcuk University Faculty of Medicine Hospital between 2011 and 2013 were included in the study...
October 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29138622/antimicrobial-efficacy-of-penicillium-amestolkiae-elv609-extract-treated-cotton-fabric-for-diabetic-wound-care
#14
Nur Amiera Syuhada Binti Rozman, Nurhanis Syafiqah Binti Mohd Nor Hamin, Leong Chean Ring, Tan Wen Nee, Mahfuzah Binti Mustapha, Tong Woei Yenn
Diabetes mellitus is a chronic disorder which affects millions of population worldwide. Global estimates published in 2010 reported the world diabetic prevalence as 6.4%, affecting 285 million adults. Foot ulceration and wound infection are major forms of disabilities arising from diabetic diseases. This study was aimed to develop a natural antimicrobial finishing on medical grade textile that meets American Association of Textiles Chemists and Colorists (AATCC) standard. The textile samples were finished with the ethanolic extract of Penicillium amestolkiae elv609, an endophytic fungus isolated from Orthosiphon stamineus Benth (common name: cat's whiskers)...
September 2017: Mycobiology
https://www.readbyqxmd.com/read/29131752/surfactants-and-their-role-in-wound-cleansing-and-biofilm-management
#15
S L Percival, D Mayer, M Malone, T Swanson, D Gibson, G Schultz
Surfactants are widely used as detergents, emulsifiers, wetting agents, foaming agents and dispersants in the cosmetics, hygiene, food and oil industries. Their use in a clinical setting is also common, particularly within the field of wound care. Many wound cleansers contain surfactants and subsequently there is available data that shows the growing potential of these wound cleansers in the enhancement of wound closure. The presence of microorganisms in wounds has been recognised as a significant factor that delay healing...
November 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29120684/managing-exudate-and-maceration-in-venous-leg-ulceration-within-the-acute-health-setting
#16
Annemarie Brown
Exudate has beneficial effects in normal wound healing but detrimental consequences for chronic wounds. Practitioners need to identify and treat its cause, and manage the exudate and prevent if from damaging periwound skin. Management involves dressings of the most appropriate absorbency and other products, and avoiding maceration of periwound skin; compression therapy is the gold standard treatment for treating oedema and venous leg ulceration. Nurses in acute settings may not have the skills to implement or maintain compression therapy; this article is intended for nurses who may have to manage these patients temporarily while they are admitted to secondary care and may not have the skills...
November 8, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29113918/the-impact-of-diabetes-on-corneal-nerve-morphology-and-ocular-surface-integrity
#17
REVIEW
Maria Markoulli, Judith Flanagan, Shyam Sunder Tummanapalli, Jenny Wu, Mark Willcox
Diabetes mellitus is a chronic disease that results from inadequate insulin production or ineffective insulin utilization. It is one of the most common systemic diseases worldwide with increasing prevalence. Diabetes mellitus is associated with premature mortality, macrovascular complications such as cardiovascular disease, and microvascular complications, including nephropathy leading to kidney failure, potentially blinding diabetic retinopathy, and diabetic neuropathy. While the retinal complications of diabetes are well recognized by eye care professionals, the effects on the ocular surface are poorly understood...
November 4, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29106911/stem-cells-niches-and-scaffolds-applications-to-burns-and-wound-care
#18
Suzanne M Watt, Jonathan M Pleat
The importance of skin to survival, and the devastating physical and psychological consequences of scarring following reparative healing of extensive or difficult to heal human wounds, cannot be disputed. We discuss the significant challenges faced by patients and healthcare providers alike in treating these wounds. New state of the art technologies have provided remarkable insights into the role of skin stem and progenitor cells and their niches in maintaining skin homeostasis and in reparative wound healing...
October 26, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29098113/hyperbaric-oxygen-therapy-and-oxygen-compatibility-of-skin-and-wound-care-products
#19
Stéphanie F Bernatchez, Joseph Tucker, Gwenael Chiffoleau
Objective: Use test methods to assess the oxygen compatibility of various wound care products. Approach: There are currently no standard test methods specifically for evaluating the oxygen compatibility and safety of materials under hyperbaric oxygen (HBO) conditions. However, tests such as the oxygen index (OI), oxygen exposure (OE), and autogenous ignition temperature (AIT) can provide useful information. Results: The OI test measures the minimum oxygen concentration that will support candle-like burning, and it was used to test 44 materials...
November 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/29025455/the-burden-of-gunshot-injuries-on-orthopaedic-healthcare-resources-in-south-africa
#20
Case Martin, Gerhard Thiart, Graham McCollum, Stephen Roche, Sithombo Maqungo
BACKGROUND: Injuries inflicted by gunshot wounds (GSWs) are an immense burden on the South African (SA) healthcare system. In 2005, Allard and Burch estimated SA state hospitals treated approximately 127 000 firearm victims annually and concluded that the cost of treating an abdominal GSW was approximately USD1 467 per patient. While the annual number of GSW injuries has decreased over the past decade, an estimated 54 870 firearm-related injuries occurred in SA in 2012. No study has estimated the burden of these GSWs from an orthopaedic perspective...
June 30, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
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