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https://www.readbyqxmd.com/read/29791703/biological-intercalary-reconstruction-with-bone-grafts-after-joint-sparing-resection-of-the-lower-limb-is-this-an-effective-and-durable-solution-for-joint-preservation
#1
Francesco Muratori, Francesca Totti, Antonio D'Arienzo, Maurizio Scorianz, Guido Scoccianti, Giovanni Beltrami, Francesco Rosario Campo, Carmine Citarelli, Rodolfo Capanna, Domenico Andrea Campanacci
Due to advances in neoadjuvant therapies and preoperative imaging modalities, joint-sparing resections have become appealing in bone tumor surgery. However, the intercalary reconstruction of metadiaphyseal bone defects of the femur and the tibia after juxta-articular tumor resection remains challenging. Both biological and prosthetic reconstructions have been used for joint-sparing resections, but little is known about the long-term outcome of these procedures. The authors reviewed a consecutive series of 64 patients treated with joint-sparing intercalary resection and reconstruction with bone grafts...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29786410/percutaneous-deep-venous-arterialization-in-patients-with-critical-limb-ischemia-a-technical-note
#2
Steven Kum, Eline Huizing, Michiel A Schreve, Çagdas Ünlü, Roberto Ferraresi, Lasitha B Samarakoon, Daniel A van den Heuvel
Critical limb ischemia (CLI) is the presentation of end stage peripheral arterial disease and typically presents with rest pain, ulceration and gangrene. The outcome of conservative treatment is poor and often leads to amputations. Arterial revascularization plays an important role in amputation prevention. Unfortunately, a significant percentage of CLI patients cannot be revascularized and subsequently end up with a palliative amputation. This has led to the need and exploration of new treatment options in this no option subgroup of CLI...
May 22, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29785118/traditional-chinese-medicine-astragalus-polysaccharide-enhanced-antitumor-effects-of-the-angiogenesis-inhibitor-apatinib-in-pancreatic-cancer-cells-on-proliferation-invasiveness-and-apoptosis
#3
Jun Wu, Jing Wang, Qiang Su, Wei Ding, Teng Li, Junxian Yu, Bangwei Cao
Background: Traditional chemotherapy and molecular targeted therapy have shown modest effects on the survival of patients with pancreatic cancer. The current study aimed to investigate the antitumor effects of apatinib, Astragalus polysaccharide (APS), and the combination of both the drugs in pancreatic cancer cells and further explore the molecular mechanisms in vitro. Materials and methods: Expression of vascular endothelial growth factor receptor-2 (VEGFR-2) in human pancreatic cancer cell lines ASPC-1, PANC-1, and SW1990 was detected by Western blotting...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29783929/modulation-the-crosstalk-between-tumor-associated-macrophages-and-non-small-cell-lung-cancer-to-inhibit-tumor-migration-and-invasion-by-ginsenoside-rh2
#4
Honglin Li, Nan Huang, Weikang Zhu, Jianchun Wu, Xiaohui Yang, Wenjing Teng, Jianhui Tian, Zhihong Fang, Yingbin Luo, Min Chen, Yan Li
BACKGROUND: Tumor-associated macrophages (TAMs) play a critical role in modulating the tumor microenvironment and promote tumor metastases. Our studies have demonstrated that ginsenoside Rh2 (G-Rh2), a monomeric compound extracted from ginseng, is a promising anti-tumor agent in lung cancer cells. However, it remains unclear whetherG-Rh2 can modulate the differentiation of TAMs and its interaction with tumor microenvironment. In this study, we investigated how G-Rh2 regulates the phenotype of macrophages and affects the migration of non-small cell lung cancer (NSCLC) cells...
May 22, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29782415/measuring-transcutaneous-oxygenation-to-validate-the-duration-required-to-achieve-electrode-equilibration
#5
Nathaniel Chiang, Jitendra K Jain, Jamie Sleigh, Thodur Vasudevan
OBJECTIVE: The transcutaneous oxygenation measurement (TCOM) system is useful in assessing tissue viability. There are no clear recommendations regarding the duration required for the electrode to equilibrate and reliably evaluate tissue oxygenation values. The objective of this study was to validate the duration required to achieve electrode equilibration in a clinical setting. METHODS: Minute-by-minute recordings using TCOM (TCOM3; Radiometer Medical ApS, Brønshøj, Copenhagen) were obtained for 82 limbs in 50 participants...
June 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29781855/improving-senescent-wound-healing-with-local-and-systemic-therapies
#6
Caroline Szpalski, Parag Butala, Meredith T Vandegrift, Denis Knobel, Robert J Allen, Pierre B Saadeh, Stephen M Warren
The population is aging, and the prevalence of chronic wounds is increasing. Because neovascularization is essential for tissue repair and both local and systemic factors affect new blood vessel formation, we hypothesize that altering either pathway would reciprocally enhance wound healing in the aged. To test this hypothesis, p53 was locally suppressed and endothelial progenitor cells (EPCs) were systemically mobilized in a murine model of senescent wound healing.Bilateral 6-mm full-thickness stented wounds were made on the dorsum of Zmpste24 mice...
May 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29781319/assessing-the-role-of-ranibizumab-in-improving-the-outcome-of-glaucoma-filtering-surgery-and-neovascular-glaucoma
#7
Andreas Katsanos, Kostantina Gorgoli, Dimitrios G Mikropoulos, Esther Arranz-Marquez, Georgios P Athanasopoulos, Miguel A Teus, Anastasios G P Konstas
Ranibizumab was the first anti-vascular endothelial growth factor (VEGF) agent approved for the treatment of neovascular age-related macular degeneration. The use of ranibizumab and other anti-VEGF medications in recent years has revolutionized the treatment of several sight-threatening retinal disorders. Emerging evidence has demonstrated that anti-VEGF treatment can offer advantages in the management of other ocular conditions where VEGFs play a key role: ocular scarring following glaucoma filtering surgery and neovascular glaucoma (NVG)...
May 19, 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29777577/autologous-bone-marrow-mesenchymal-stem-cells-improve-the-quality-and-stability-of-vascularized-flap-surgery-of-irradiated-skin-in-pigs
#8
Christine Linard, Michel Brachet, Carine Strup-Perrot, Bruno L'homme, Elodie Busson, Claire Squiban, Valerie Holler, Michel Bonneau, Jean-Jacques Lataillade, Eric Bey, Marc Benderitter
Cutaneous radiation syndrome has severe long-term health consequences. Because it causes an unpredictable course of inflammatory waves, conventional surgical treatment is ineffective and often leads to a fibronecrotic process. Data about the long-term stability of healed wounds, with neither inflammation nor resumption of fibrosis, are lacking. In this study, we investigated the effect of injections of local autologous bone marrow-derived mesenchymal stromal cells (BM-MSCs), combined with plastic surgery for skin necrosis, in a large-animal model...
May 18, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29772758/antioxidant-capacity-of-rigenase-%C3%A2-a-specific-aqueous-extract-of-triticum-vulgare
#9
Immacolata Antonucci, Gabriella Fiorentino, Patrizia Contursi, Massimiliano Minale, Rodolfo Riccio, Salvatore Riccio, Danila Limauro
Reactive species of oxygen (ROS), responsible for oxidative stress, accumulate in various tissues damaged by burns, decubitus ulcers, and vascular lesions. Antioxidants play an important and well-documented role in healing of chronic and acute wounds. Rigenase® , a specific extract of Triticum vulgare manufactured by Farmaceutici Damor, is employed in products used for the regeneration of tissue injuries. In this work, we show that Rigenase® exhibits a scavenging effect toward free radicals, thus pointing to its relevant antioxidant activity...
May 17, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29772391/development-of-ionic-liquid-assisted-synthesized-nano%C3%A2-silver-combined-with-vascular-endothelial-growth-factor-as-wound-healing-in-the-care-of-femoral-fracture-in-the-children-after-surgery
#10
Xingli Li, Maohua Liu, Hongxia Cheng, Qun Wang, Chuanna Miao, Shumei Ju, Fang Liu
This investigation aimed to develop the silver (Ag) nanoparticles incorporated vascular endothelial growth factor (VEGF) for the improvement wound healing and reduce Aseptic necrosis in treatment of femoral fracture healing. The spherical shaped Ag nanoparticles with improved morphology have been effectively synthesized via microwave assisted method using ionic liquids 1-dodecyl-3-methylimidazolium chloride. The morphological structure and crystalline properties of Ag nanoparticles are analyzed by using UV, XRD and TEM-EDX analytical methods...
March 6, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29770194/clinical-utility-of-hyperbaric-oxygen-therapy-in-genitourinary-medicine
#11
REVIEW
Jason Gandhi, Omar Seyam, Noel L Smith, Gunjan Joshi, Sohrab Vatsia, Sardar Ali Khan
Hyperbaric oxygen therapy (HBOT) is a medical technique which delivers oxygen at ambient pressures to increase the amount of dissolved oxygen in the blood and oxygen distribution to tissues. There are several beneficial properties of HBOT concomitant with elevated oxygen distribution in tissue including anti-inflammation, angiogenesis through vascular endothelial growth factor proliferation, augmented fibroblast activity through fibroblast growth factor proliferation, tissue and wound repair, enhancement of lymphocyte and macrophage activity, increased male testosterone secretion, and bactericidal activity...
January 2018: Medical Gas Research
https://www.readbyqxmd.com/read/29764587/-role-of-pd-0332991-on-the-proliferation-and-apoptosis-of-vascular-endothelial-cells
#12
Chenlong Zhao, Minghui Liu, Yongwen Li, Hongbing Zhang, Ying Li, Hao Gong, Yin Yuan, Weiting Li, Hongyu Liu, Jun Chen
BACKGROUND: Angiogenesis is an important process in the development of tumor. PD 0332991, a cell cycle inhibitor, can specifically inhibit CD4/6 phosphorylation and cell cycle progression. In xeongraft mice models, PD 0332991 treated mice had significantly decreased angiogenesis and vascular density compared with the control group, but the mechanism remains unknown. The purpose of this study is to investigate the role and molecular mechanism of PD 0332991 on vascular endothelial cells...
May 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29763904/treatment-of-cutaneous-ulcers-with-multilayered-mixed-sheets-of-autologous-fibroblasts-and-peripheral-blood-mononuclear-cells
#13
Takahiro Mizoguchi, Koji Ueno, Yuriko Takeuchi, Makoto Samura, Ryo Suzuki, Tomoaki Murata, Tohru Hosoyama, Noriyasu Morikage, Kimikazu Hamano
BACKGROUND/AIMS: We have developed a mixed-cell sheet consisting of autologous fibroblasts and peripheral blood mononuclear cells with a high potency for angiogenesis and wound healing against refractory cutaneous ulcers in mouse and rabbit models. To increase the effectiveness of the mixed sheet, we developed a multilayered mixed sheet. METHODS: We assessed the therapeutic effects of multilayered sheets on cutaneous ulcers in mice. Growth factors and chemokines were assessed by enzyme-linked immunosorbent assay...
May 10, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29763436/treatment-of-limb-wounds-of-horses-with-orf-virus-il-10-and-vegf-e-accelerates-resolution-of-exuberant-granulation-tissue-but-does-not-prevent-its-development
#14
Lyn M Wise, Christa J Bodaan, Gabriella S Stuart, Nicola C Real, Zabeen Lateef, Andrew A Mercer, Christopher B Riley, Christine L Theoret
Bandaging of limb wounds in horses leads to formation of exuberant granulation tissue (EGT) that retards healing due to protracted inflammation, aberrant vascularisation and delayed epithelialisation. EGT is not observed if wounds are left undressed or when wounds are on the body. A previous study showed that short-term administration of proteins derived from orf virus dampened inflammation and promoted epithelialisation of open wounds in horses. Here, we investigated the impact of orf virus interleukin-10 and vascular endothelial growth factor-E on the development and resolution of EGT...
2018: PloS One
https://www.readbyqxmd.com/read/29762829/the-role-of-mir-99b-in-mediating-hepatocellular-carcinoma-invasion-and-migration
#15
C-J Liu, J-H Yang, F-Z Huang, J-H Yang, C-P Liu, X-H Mao, W-M Yi, X-B Shen, C Peng, M-F Chen, B Jiang, J-S Wu
OBJECTIVE: Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults with a high rate of malignancy. The potent invasion and migration of HCC mainly impact the prognosis and recurrence of the disease. Our previous study found that miR-99b was highly expressed in HCC, and its expression was associated with vascular invasion. It was speculated that miR-99b may play a role in HCC invasion and migration, while the specific mechanism remains unclear. MATERIALS AND METHODS: qRT-PCR was applied to detect expressions of miR-99b and KAI1 genes in L02, HepG2, and MHCC97H cells...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29757677/microrna-dysregulation-in-pulmonary-arteries-from-copd-relationships-with-vascular-remodeling
#16
Melina M Musri, Núria Coll-Bonfill, Bradley A Maron, Víctor I Peinado, Ruisheng Wang, Jordi Altirriba, Isabel Blanco, William M Oldham, Olga Tura-Ceide, Jessica García-Lucio, Benjamin de la Cruz-Thea, Gunter Meister, Joseph Loscalzo, Joan A Barberà
BACKGROUND: Pulmonary vascular remodeling is an angiogenic-related process involving changes in smooth muscle cell (SMC) homeostasis, which is frequently observed in chronic obstructive pulmonary disease (COPD). MicroRNAs (miRNAs) are small non-coding RNAs that regulate mRNA expression levels of many genes leading to the manifestation of cell identity and specific cellular phenotypes. Here we evaluate the miRNA expression profiles of pulmonary arteries (PA) of patients with COPD and its relationship with the regulation of SMC phenotypic change...
May 14, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29755850/three-dimensional-printing-and-cell-therapy-for-wound-repair
#17
REVIEW
Sylvia van Kogelenberg, Zhilian Yue, Jeremy N Dinoro, Christopher S Baker, Gordon G Wallace
Significance: Skin tissue damage is a major challenge and a burden on healthcare systems, from burns and other trauma to diabetes and vascular disease. Although the biological complexities are relatively well understood, appropriate repair mechanisms are scarce. Three-dimensional bioprinting is a layer-based approach to regenerative medicine, whereby cells and cell-based materials can be dispensed in fine spatial arrangements to mimic native tissue. Recent Advances: Various bioprinting techniques have been employed in wound repair-based skin tissue engineering, from laser-induced forward transfer to extrusion-based methods, and with the investigation of the benefits and shortcomings of each, with emphasis on biological compatibility and cell proliferation, migration, and vitality...
May 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29751537/-mcpip3-as-a-potential-metastasis-suppressor-gene-in-human-colorectal-cancer
#18
Fat-Moon Suk, Chi-Ching Chang, Ren-Jye Lin, Shyr-Yi Lin, Ya-Ting Chen, Yu-Chih Liang
Monocyte chemotactic protein induced protein 3 (MCPIP3) belongs to the Cys⁻Cys⁻Cys⁻His (CCCH)-zinc finger protein family and contains a highly conserved CCCH-zinc finger domain and a Nedd4-BP1 YacP nuclease (NYN) domain. Previous studies showed that MCPIP3 inhibits the expression of proinflammatory genes, such as vascular cell adhesion molecule ( VCAM )-1, in human endothelial cells, but the roles and functions of MCPIP3 in cancer cells are still unknown. In human colorectal cancer specimens, we found that the messenger RNA expression of MCPIP3 was significantly downregulated in cancer tissues compared to adjacent normal tissues (18/25; average fold change of 8...
May 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29750813/autophagy-mediates-tumor-necrosis-factor-%C3%AE-induced-phenotype-switching-in-vascular-smooth-muscle-a7r5-cell-line
#19
Marina García-Miguel, Jaime A Riquelme, Ignacio Norambuena-Soto, Pablo E Morales, Fernanda Sanhueza-Olivares, Constanza Nuñez-Soto, David Mondaca-Ruff, Nicole Cancino-Arenas, Alejandra San Martín, Mario Chiong
Vascular smooth muscle cells (VSMC) dedifferentiation from a contractile to a synthetic phenotype contributes to atherosclerosis. Atherosclerotic tissue has a chronic inflammatory component with high levels of tumor necrosis factor-α (TNF-α). VSMC of atheromatous plaques have increased autophagy, a mechanism responsible for protein and intracellular organelle degradation. The aim of this study was to evaluate whether TNF-α induces phenotype switching of VSMCs and whether this effect depends on autophagy...
2018: PloS One
https://www.readbyqxmd.com/read/29750309/knockdown-of-ran-gtpase-expression-inhibits-the-proliferation-and-migration-of-breast-cancer-cells
#20
Chenyi Sheng, Jian Qiu, Yingying Wang, Zhixian He, Hua Wang, Qingqing Wang, Yeqing Huang, Lianxin Zhu, Feng Shi, Yingying Chen, Shiyao Xiong, Zhen Xu, Qichao Ni
Breast cancer is the second leading cause of cancer‑associated mortality in women worldwide. Strong evidence has suggested that Ran, which is a small GTP binding protein involved in the transport of RNA and protein across the nucleus, may be a key cellular protein involved in the metastatic progression of cancer. The present study investigated Ran gene expression in breast cancer tissue samples obtained from 140 patients who had undergone surgical resection for breast cancer. Western blot analysis of Ran in breast cancer tissues and paired adjacent normal tissues showed that expression of Ran was significantly increased in breast cancer tissues...
May 3, 2018: Molecular Medicine Reports
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