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https://www.readbyqxmd.com/read/29774399/endothelial-dysfunction-following-coronary-artery-bypass-grafting-influence-of-patient-and-procedural-factors
#1
J Hadem, R Rossnick, B Hesse, M Herr, M Hansen, A Bergmann, G Kensah, C Maess, H Baraki, P Kümpers, A Lukasz, I Kutschka
BACKGROUND: Angiopoietin-2 (Angpt2) mediates endothelial dysfunction (ED) following coronary artery bypass grafting (CABG). Its triggers are, however, poorly understood. METHODS: We examined the time course of ED beyond the early phase of postoperative recovery in 75 patients following CABG with a special focus on different cardiopulmonary bypass (CPB) modes as potential triggers of Angpt2 release. RESULTS: Nine patients (12.0%) underwent off-pump coronary artery bypass (OPCAB), 31 patients (41...
May 17, 2018: Herz
https://www.readbyqxmd.com/read/29735560/the-novel-phage-derived-antimicrobial-agent-hy-133-is-active-against-livestock-associated-methicillin-resistant-staphylococcus-aureus-la-mrsa
#2
Ursula Kaspar, Jorge A de Haro Sautto, Sonja Molinaro, Georg Peters, Evgeny A Idelevich, Karsten Becker
Livestock-associated, methicillin-resistant Staphylococcus aureus (LA-MRSA) are increasingly migrating from livestock into human and animal health care settings. Alternative substances are wanted to overcome the drawbacks of currently available drugs applied for MRSA eradication. The recombinant bacteriophage endolysin HY-133 has been proven as an active agent against S. aureus Here, the in vitro activity of HY-133 was studied against a large collection of genetically diverse LA-MRSA revealing its high activity against mecA, mecB and mecC LA-MRSA...
May 7, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29685228/phenotypic-and-genotypic-characteristics-of-staphylococcus-aureus-isolates-from-zoo-and-wild-animals
#3
Andrea T Feßler, Patricia Thomas, Kristin Mühldorfer, Mirjam Grobbel, Julian Brombach, Inga Eichhorn, Stefan Monecke, Ralf Ehricht, Stefan Schwarz
Antimicrobial resistance of Staphylococcus aureus is a major problem in human and veterinary medicine. The aim of this study was to characterise S. aureus isolates from wild and zoo animals mainly associated with bacterial infections. In total, 23 S. aureus isolates, including nine from wild animals and 14 from zoo animals, were obtained during routine diagnostics. All isolates were subjected to multilocus sequence typing (MLST), spa typing, macrorestriction analysis with subsequent SmaI pulsed-field gelelectrophoresis (PFGE), antimicrobial susceptibility testing and S...
May 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29674044/the-increase-of-detection-sensitivity-of-micellar-electrokinetic-capillary-chromatography-method-of-stamp-pad-inks-components-by-applying-a-sample-stacking-mode-for-the-purpose-of-questioned-document-examination
#4
Marta Gładysz, Małgorzata Król, Michał Woźniakiewicz, Paweł Kościelniak
The study focused on comparison of on-line sample concentration techniques, i.e. sample stacking modes, applied in capillary electrophoresis in order to improve the detection of components of stamp pad inks so that destruction of analysed document could be minimized. In particular, such techniques were taken into consideration as: normal stacking mode/field amplified sample stacking (NSM/FASS), high-salt concentration, sweeping, electrokinetic injection + FASS, and field enhanced sample injection (FESI). At first, two mixtures of 4 red dyes and 4 violet/blue dyes were examined...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29555636/genetic-determinants-of-high-level-oxacillin-resistance-in-mrsa
#5
Maria Pardos de la Gandara, Vitor Borges, Marilyn Chung, Catarina Milheiriço, João Paulo Gomes, Herminia de Lencastre, Alexander Tomasz
Methicillin-resistant Staphylococcus aureus (MRSA) strains carry either a mecA - or a mecC -mediated mechanism of resistance to beta-lactam antibiotics and the phenotypic expression of resistance shows extensive strain-to-strain variation. In recent communications we identified genetic determinants associated with the stringent stress response that play a major role in the antibiotic resistant phenotype of the historically earliest "archaic" clone of MRSA and in the mecC carrying MRSA strain LGA251...
March 19, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29524153/small-mammals-as-sentinels-of-antimicrobial-resistant-staphylococci
#6
Vladimír Kmeť, Anna Čuvalová, Michal Stanko
A total of 39 coagulase-negative staphylococci and seven Staphylococcus aureus strains were isolated from small mammal feces, i.e., the striped field mouse (Apodemus agrarius) and the yellow-necked mouse (A. flavicollis) in two sampling areas, deciduous forest and karst plains. MALDI-TOF analysis revealed five species of coagulase-negative staphylococci: S. sciuri, S. hominis, S. warneri, S. haemolyticus, and S. xylosus. All strains were susceptible to tetracycline, linezolid, vancomycin, and teicoplanin. Three MRSA strains with the mecA gene were detected...
March 9, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29523917/how-do-different-extracorporeal-circulation-systems-affect-metoprolol-bioavailability-in-coronary-artery-bypass-surgery-patients
#7
Hannu Kokki, Martin Maaroos, Sten Ellam, Jari Halonen, Ilkka Ojanperä, Merja Ranta, Veli-Pekka Ranta, Aleksandra Tolonen, Oscar Lindberg, Matias Viitala, Juha Hartikainen
PURPOSE: Cardiac surgery and conventional extracorporeal circulation (CECC) impair the bioavailability of drugs administered by mouth. It is not known whether miniaturized ECC (MECC) or off-pump surgery (OPCAB) affect the bioavailability in similar manner. We evaluated the metoprolol bioavailability in patients undergoing CABG surgery with CECC, MECC, or having OPCAB. METHODS: Thirty patients, ten in each group, aged 44-79 years, scheduled for CABG surgery were administered 50 mg metoprolol by mouth on the preoperative day at 8-10 a...
June 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29468193/scc-mec-finder-a-web-based-tool-for-typing-of-staphylococcal-cassette-chromosome-mec-in-staphylococcus-aureus-using-whole-genome-sequence-data
#8
Hülya Kaya, Henrik Hasman, Jesper Larsen, Marc Stegger, Thor Bech Johannesen, Rosa Lundbye Allesøe, Camilla Koldbæk Lemvigh, Frank Møller Aarestrup, Ole Lund, Anders Rhod Larsen
Typing of methicillin-resistant Staphylococcus aureus (MRSA) is important in infection control and surveillance. The current nomenclature of MRSA includes the genetic background of the S. aureus strain determined by multilocus sequence typing (MLST) or equivalent methods like spa typing and typing of the mobile genetic element staphylococcal cassette chromosome mec (SCC mec ), which carries the mecA or mecC gene. Whereas MLST and spa typing are relatively simple, typing of SCC mec is less trivial because of its heterogeneity...
January 2018: MSphere
https://www.readbyqxmd.com/read/29426410/diversity-of-methicillin-resistant-staphylococcus-aureus-mrsa-isolated-from-austrian-ruminants-and-new-world-camelids
#9
B Schauer, R Krametter-Frötscher, F Knauer, R Ehricht, S Monecke, A T Feßler, S Schwarz, T Grunert, J Spergser, I Loncaric
The aim of this study was to determine the prevalence, the antimicrobial resistance patterns and the genetic diversity of methicillin-resistant Staphylococcus aureus (MRSA) from Austrian ruminants and New World camelids that were treated at the University of Veterinary Medicine, Vienna. Between April 2014 and January 2017, 723 nasal swabs originating from ruminants and New World camelids were examined. MRSA isolates were characterized by mecA/mecA1/mecC PCRs and by DNA microarray analysis. They were genotyped by spa typing, dru typing, MLST and MLVA...
February 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29410104/evaluation-of-a-novel-optical-assay-for-rapid-detection-of-methicillin-resistant-staphylococcus-aureus-in-liquid-culture
#10
Dennis Knaack, Evgeny A Idelevich, Barbara Körber-Irrgang, Michael Kresken, Karsten Becker
Valid detection of methicillin-resistant Staphylococcus aureus (MRSA) is a precondition for MRSA prevention measures. Most of the available MRSA screening tests are based either on the identification of colony material grown on solid agar media or on direct molecular approaches. The HB&L MRSA KIT (Alifax, Polverara, Italy) is designed to screen for MRSA in liquid cultures applying the light scattering technology. Here, the assay was evaluated with pure culture isolates from solid agar media on a representative subset of 29 MRSA and 171 methicillin-susceptible S...
March 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29408763/multiple-pharmacological-activities-of-caesalpinia-crista-against-aluminium-induced-neurodegeneration-in-rats-relevance-for-alzheimer-s-disease
#11
Sunil K Ravi, Balenahalli Narasingappa Ramesh, Ravi Mundugaru, Bruno Vincent
Alzheimer's disease (AD) is the most common form of dementia and mainly affects cognitive function of the aged populations. Aluminium, a neurotoxic metal, has been suggested as a contributing factor of AD. Caesalpinia crista is a medicinal plant known for its anti-microbial, anti-inflammatory and anti-oxidant properties. The present study was conducted in order to evaluate the neuroprotective effects of methanolic extracts of C. crista (MECC) on aluminium-induced neurodegeneration in rats. Co-administration with MECC significantly and dose dependently ameliorated the aluminium-dependent cognitive impairment, AChE hyperactivity and oxidative stress in the hippocampus and in the frontal cortex of rat brain...
March 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29397175/short-communication-characterization-of-staphylococcus-aureus-isolated-along-the-raw-milk-cheese-production-process-in-artisan-dairies-in-italy
#12
S Johler, G Macori, A Bellio, P L Acutis, S Gallina, L Decastelli
Staphylococcus aureus is a common cause of food-borne intoxications. Several staphylococcal food poisoning outbreaks have been linked to consumption of raw milk cheeses and artisanal cheese production. However, information on Staph. aureus isolated from artisanal raw milk cheeses and small-scale dairy production environments is very limited. Therefore, we aimed to characterize Staph. aureus isolated along the artisanal raw milk production chain by determining (1) the population structure, and (2) the presence/absence of enterotoxin genes, mecA/C, and pvl...
April 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29391306/incidence-patterns-of-colorectal-cancers-in-four-countries-of-the-middle-east-cancer-consortium-cyprus-jordan-israel-and-%C3%A4-zmir-turkey-compared-with-those-in-the-united-states-surveillance-epidemiology-and-end-results-program
#13
Sultan Eser, Jenny Chang, Haris Charalambous, Barbara Silverman, Anna Demetriou, Cankut Yakut, Omar Nimri, Pavlos Pavlou, Suriye Özgür, Argyrious Ziogas, Lisa Stevens, Kevin Ward, Hoda Anton Culver
BACKGROUND/AIMS: There are wide variations in colorectal cancer (CRC) incidence across the world. Historically, the highest incidence rates have been reported historically in more developed countries; however, increasing trends have been seen in developing countries. Here, we present the CRC incidence pattern in Cyprus, Israel, Jordan, and İzmir, Turkey, which are countries of the Middle East Cancer Consortium (MECC). MATERIALS AND METHODS: We analyzed 2005-2010 CRC data from population-based registries and calculated crude and age standardized rates for CRC, colon and rectum subsites, and annual percent changes (APCs) for trends...
January 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29350135/plasmid-encoded-transferable-mecb-mediated-methicillin-resistance-in-staphylococcus-aureus
#14
Karsten Becker, Sarah van Alen, Evgeny A Idelevich, Nina Schleimer, Jochen Seggewiß, Alexander Mellmann, Ursula Kaspar, Georg Peters
During cefoxitin-based nasal screening, phenotypically categorized methicillin-resistant Staphylococcus aureus (MRSA) was isolated and tested negative for the presence of the mecA and mecC genes as well as for the SCCmec-orfX junction region. The isolate was found to carry a mecB gene previously described for Macrococcus caseolyticus but not for staphylococcal species. The gene is flanked by β-lactam regulatory genes similar to mecR, mecI, and blaZ and is part of an 84.6-kb multidrug-resistance plasmid that harbors genes encoding additional resistances to aminoglycosides (aacA-aphD, aphA, and aadK) as well as macrolides (ermB) and tetracyclines (tetS)...
February 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29324747/association-of-atrial-fibrillation-and-cancer-analysis-from-two-large-population-based-case-control-studies
#15
Walid Saliba, Hedy S Rennert, Naomi Gronich, Stephen B Gruber, Gad Rennert
BACKGROUND: An association between atrial fibrillation (AF) and risk of cancer has been suggested in several studies, including prospective cohort studies. However, the magnitude and the temporal nature of this association remain unclear. METHODS: Data from two large prospective population-based case-control studies, the Molecular Epidemiology of Colorectal Cancer (MECC, n = 8,383) and the Breast Cancer in Northern Israel Study (BCINIS, n = 11,608), were used to better understand the nature and temporality of a possible association between cancer diagnosis and AF events before and after cancer diagnosis...
2018: PloS One
https://www.readbyqxmd.com/read/29118173/-mecc-harboring-methicillin-resistant-staphylococcus-aureus-hiding-in-plain-sight
#16
Bradley A Ford
Previously there was scant data on the performance of laboratory testing to detect mecC -mediated beta-lactam resistance in Staphylococcus aureus Kriegeskorte and colleagues (J Clin Microbiol 56:e00826-17, 2018, https://doi.org/10.1128/JCM.00826-17) report the performance of various clinical tests for the detection of mecC -harboring methicillin-resistant S. aureus (MRSA), which failed to identify from 0 to 41% of tested mecC -harboring MRSA isolates. Changes in practice and new test development are necessary to address the challenge of mecC -harboring MRSA...
January 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29079617/-staphylococcus-edaphicus-sp-nov-isolated-in-antarctica-harbours-mecc-gene-and-genomic-islands-with-suspected-role-in-adaptation-to-extreme-environment
#17
Roman Pantůček, Ivo Sedláček, Adéla Indráková, Veronika Vrbovská, Ivana Mašlaňová, Vojtěch Kovařovic, Pavel Švec, Stanislava Králová, Lucie Krištofová, Jana Kekláková, Petr Petráš, Jiří Doškař
Two Gram-stain-positive, coagulase-negative staphylococcal strains were isolated from abiotic sources, stone fragments and sandy soil in James Ross Island, Antarctica. Here we describe properties of novel species of the genus Staphylococcus that has near identical 16S rRNA gene sequence to Staphylococcus saprophyticus However, compared to S. saprophyticus and the next closest relatives, the new species demonstrates considerable phylogenetic distance at whole genome level, average nucleotide identity <85 %, and inferred DNA-DNA hybridization <30%...
October 27, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29063353/high-prevalence-and-antimicrobial-resistance-of-meca-staphylococcus-aureus-in-dairy-cattle-sheep-and-goat-bulk-tank-milk-in-jordan
#18
Mohammad M Obaidat, Alaa E Bani Salman, Amira A Roess
The aim of this study was to determine the prevalence and antimicrobial resistance of mecA and mecC methicillin-resistant Staphylococcus aureus (MRSA) in cattle, sheep, and goat dairy farms in Jordan. Milk samples were collected from bulk tanks at 117 dairy farms (44 cattle, 47 sheep, and 26 goat dairy farms) in each region of the country. MRSA were isolated on mecA and mecC chromogenic media and confirmed by PCR. The confirmed isolates were tested for resistance toward 15 antimicrobials by the disc diffusion method...
February 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29051059/first-report-of-the-staphylococcus-aureus-isolate-from-subclinical-bovine-mastitis-in-the-south-of-brazil-harboring-resistance-gene-dfrg-and-transposon-family-tn916-1545
#19
Louise Haubert, Isabela Schneid Kroning, Mariana Almeida Iglesias, Wladimir Padilha da Silva
The aim of this work was to identify at the molecular level the species of coagulase-positive staphylococci isolates from clinical and subclinical bovine mastitis samples in Southern Brazil, and to evaluate the antimicrobial resistance profile, as well as the presence of resistance genes. According to the PCR assay, all 31 isolates were classified as Staphylococcus aureus. The isolates were tested for resistance to penicillin, ampicillin, oxacillin, cefoxitin, cephalothin, ceftiofur, streptomycin, tobramycin, teicoplanin, erythromycin, clindamycin, enrofloxacin, sulfonamide, trimethoprim-sulfamethoxazole, trimethoprim, and tetracycline by the disk diffusion method...
December 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28978682/comparison-of-different-phenotypic-approaches-to-screen-and-detect-mecc-harboring-methicillin-resistant-staphylococcus-aureus
#20
André Kriegeskorte, Evgeny A Idelevich, Andreas Schlattmann, Franziska Layer, Birgit Strommenger, Olivier Denis, Gavin K Paterson, Mark A Holmes, Guido Werner, Karsten Becker
Similar to mecA , mecC confers resistance against beta-lactams, leading to the phenotype of methicillin-resistant Staphylococcus aureus (MRSA). However, mecC -harboring MRSA strains pose special difficulties in their detection. The aim of this study was to assess and compare different phenotypic systems for screening, identification, and susceptibility testing of mecC -positive MRSA isolates. A well-characterized collection of mecC -positive S. aureus isolates ( n = 111) was used for evaluation. Routinely used approaches were studied to determine their suitability to correctly identify mecC -harboring MRSA, including three (semi)automated antimicrobial susceptibility testing (AST) systems and five selective chromogenic agar plates...
January 2018: Journal of Clinical Microbiology
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