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https://www.readbyqxmd.com/read/29679854/thymol-attenuates-the-worsening-of-atopic-dermatitis-induced-by-staphylococcus-aureus-membrane-vesicles
#1
Hyo Il Kwon, Na Hee Jeong, So Hyun Jun, Joo Hee Son, Shukho Kim, Hyejin Jeon, Sun Chul Kang, Sang Hyun Kim, Je Chul Lee
Staphylococcus aureus membrane vesicles (MVs) aggravate atopic dermatitis (AD) through the delivery of bacterial effector molecules to host cells and the stimulation of inflammatory responses. This study investigated the inhibitory effect of thymol, a phenolic monoterpene found in essential oils derived from plants, on the worsening of AD induced by S. aureus MVs both in vitro and in vivo. The sub-minimal inhibitory concentrations of thymol disrupted S. aureus MVs. Intact S. aureus MVs induced the expression of pro-inflammatory cytokine (interleukin (IL)-1β, IL-6, and tumor necrosis factor-α) and chemokine (IL-8 and monocyte chemoattractant protein-1) genes in cultured keratinocytes, whereas thymol-treated S...
April 18, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29679551/histological-and-mechanical-evaluation-of-antifreeze-peptide-afp1m-cryopreserved-skin-grafts-post-transplantation-in-a-rat-model
#2
S M Ibrahim, O H Kareem, K M Saffanah, A A Adamu, M S Khan, M B A Rahman, M M Noordin, M Y Loqman
The objective of this study was to evaluate the use of Afp1m as a cryopreservative agent for skin by examining the transplanted skin histological architecture and mechanical properties following subzero cryopreservation. Thirty four (34) rats with an average weight of 208 ± 31 g (mean ± SD), were used. Twenty four (n = 24) rats were equally divided into four groups: (i) immediate non-cryopreserved skin autografts (onto same site), (ii) immediate non-cryopreserved skin autografts (onto different sites), (iii) skin autografts cryopreserved with glycerol for 72 h and (iv) skin autografts cryopreserved with Afp1m for 72 h at -4 °C...
April 18, 2018: Cryobiology
https://www.readbyqxmd.com/read/29679487/allergen-specific-immunotherapy-induces-regulatory-t-cells-in-an-atopic-dermatitis-mouse-model
#3
Jung U Shin, Seo Hyeong Kim, Ji Yeon Noh, Ji Hye Kim, Kim Hye Ran, Kyoung Yong Jeong, Kyung Hee Park, Jungsoo Lee, Howard Chu, Jae-Hyun Lee, Tai-Soon Yong, Jung-Won Park, Kwang Hoon Lee
BACKGROUND: Several studies have demonstrated that allergen-specific immunotherapy (SIT) can be an effective treatment for atopic dermatitis (AD). However, there is no relevant mouse model to investigate the mechanism and validate the novel modality of SIT in AD. METHODS: NC/Nga mice with induced AD-like skin lesions received a subcutaneous injection of SIT (an extract of the house dust mite Dermatophagoides farinae [DfE]) or placebo for 5 weeks). Clinical and histological improvements of AD-like skin lesions were examined...
April 21, 2018: Allergy
https://www.readbyqxmd.com/read/29679385/genus-level-identification-of-dermatophytes-by-maldi-tof-ms-after-two-days-of-colony-growth
#4
Jari Intra, Cecilia Sarto, Natalia Tiberti, Silvia Besana, Cinzia Savarino, Paolo Brambilla
Matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS) is becoming a popular technology in clinical microbiology. It is a fast and highly specific method for the routine identification of microorganisms. In this study, we evaluated the suitability of dermatophyte identification after only two days of colony growth using MALDI-TOF MS. Two protein extraction protocols were also evaluated consisting of either formic acid alone or of ethanol-formic acid-acetonitrile to achieve a complete protein extraction...
April 21, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29679202/tick-infestation-and-occurrence-of-anaplasma-phagocytophilum-and-piroplasms-in-cattle-in-the-republic-of-serbia
#5
Ana Vasić, Marion Nieder, Nemanja Zdravković, Jovan Bojkovski, Dejan Bugarski, Ivan Pavlović, Cornelia Silaghi
Ticks transmit important pathogens affecting cattle such as intracellular bacteria of the genus Anaplasma or protozoa of the order Piroplasmida. This study aimed at assessing tick species present on pastures and cattle and determining occurrence of the tick-borne pathogens Anaplasma phagocytophilum and Babesia spp. in cattle. During May and June 2013, ticks and EDTA blood were collected from 185 dairy cows at six locations in Serbia. Ticks were also collected directly from the pastures at four of these locations...
April 20, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29679091/excluding-severe-bacterial-infection-in-neutrophilic-dermatoses-with-systemic-manifestations-negative-predictive-value-of-procalcitonin
#6
Pei Ming Yeo, Yik Weng Yew, Hong Liang Tey
No abstract text is available yet for this article.
March 2018: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/29678752/thromboxane-a2-facilitates-il-17a-production-from-v%C3%AE-4-%C3%AE-%C3%AE-t-cells-and-promotes-psoriatic-dermatitis-in-mice
#7
Yuri Ueharaguchi, Tetsuya Honda, Nobuhiro Kusuba, Sho Hanakawa, Akimasa Adachi, Yu Sawada, Atsushi Otsuka, Akihiko Kitoh, Teruki Dainichi, Gyohei Egawa, Chisa Nakashima, Saeko Nakajima, Teruasa Murata, Sachiko Ono, Makoto Arita, Shuh Narumiya, Yoshiki Miyachi, Kenji Kabashima
Thromboxane A2 -TP signaling facilitates IL-17A production from dermal Vγ4+ γδ T cells and promotes psoriatic dermatitis in mice. Regulation of TP activation may become a novel therapeutic target for psoriasis.
April 17, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29678596/evaluation-of-acute-skin-toxicity-of-breast-radiotherapy-using-thermography-results-of-a-prospective-single-centre-trial
#8
O Maillot, N Leduc, V Atallah, P Escarmant, A Petit, S Belhomme, P Sargos, V Vinh-Hung
PURPOSE: Radiotherapy is a common adjuvant treatment of breast cancer. Acute radiation-induced dermatitis is a frequent side effect. We hypothesized whether it is possible to capture the increase of local temperature as a surrogate of the inflammatory state induced by radiotherapy. We designed a prospective, observational, single-centre study to acquire data on temperature rise in the treated breast during the course of radiotherapy, establish a possible association with the occurrence of dermatitis and investigate the predictive value of temperature increase in future occurrences of radiation-induced dermatitis...
April 17, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29678478/immunohistochemical-cd271-expression-correlates-with-melanoma-progress-in-a-case-control-study
#9
Patricia Switten Nielsen, Rikke Riber-Hansen, Torben Steiniche
Putative cancer stem cell (CSC) markers have arisen from melanoma mouse and in vitro models, but their expression in paraffin embedded patient samples relative to clinical outcome remains largely unexplored. Rather than cells of the tumour bulk, conceivably, CSC drive tumour progression. Accordingly, complete eradication may prevent melanoma relapse. Because elevated tumour-cell proliferation is an established indicator of aggressive disease, this study aimed to investigate the correlation between melanoma recurrence and proliferation of putative CSC that express CD271, CD166, or CD20...
April 17, 2018: Pathology
https://www.readbyqxmd.com/read/29678394/-dermatologic-toxicities-of-immune-checkpoint-inhibitors
#10
REVIEW
V Sibaud, S Boulinguez, C Pagès, L Riffaud, L Lamant, C Chira, S Boyrie, E Vigarios, E Tournier, N Meyer
The development of immune checkpoint inhibitors (monoclonal antibodies targeting PD-1/PD-L1 or CTLA-4) represents a significant advance in the treatment of multiple cancers. Given their particular mechanism of action, which involves triggering CD4+/CD8+ T-cell activation and proliferation, they are associated with a specific safety profile. Their adverse events are primarily immune-related, and can affect practically all organs. In this context, dermatological toxicity is the most common, though it mostly remains mild to moderate and does not require discontinuation of treatment...
April 17, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29678379/desquamative-gingivitis-diagnosis-and-treatment
#11
REVIEW
Andrea D Maderal, Paul Lee Salisbury, Joseph L Jorizzo
Desquamative gingivitis is a clinical finding with several potential etiologies, and therefore histologic examination should be performed to confirm the diagnosis before the implementation of systemic therapy. The best methods for obtaining a mucosal biopsy specimen are discussed to aid the dermatologist in approaching these patients, and indications for additional testing, such as immunofluorescence studies, are reviewed. Desquamative gingivitis is uncommon, and there are no systematic guidelines to assist the physician in treatment, producing a practice gap in management...
May 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29678378/desquamative-gingivitis-clinical-findings-and-diseases
#12
REVIEW
Andrea D Maderal, Paul Lee Salisbury, Joseph L Jorizzo
Desquamative gingivitis is a clinical finding with several potential etiologies. Among the most common are oral lichen planus, cicatricial pemphigoid, and pemphigus vulgaris, though various other differential diagnoses exist. The presence of desquamative gingivitis often results in poor oral hygiene, which can have downstream consequences, including periodontitis and tooth loss. Though certain mucosal findings may be suggestive of a particular diagnosis, a thorough history, physical examination, and appropriate dermato- and immunopathologic assessment is necessary for narrowing this broad differential diagnosis...
May 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29678377/introducing-a-curriculum-in-ethics-and-professionalism-for-dermatology-residencies
#13
EDITORIAL
Benjamin K Stoff, Jane M Grant-Kels, Robert T Brodell, Amy S Paller, Clifford S Perlis, Eliot Mostow, David Pariser, Lionel Bercovitch
There is general agreement on what constitutes ethical reasoning and professional behavior, but standardized methods to teach these skills in dermatology residency are currently unavailable. We introduce a model curriculum designed to impart the knowledge and skills to meet the Accreditation Council for Graduate Medical Education Dermatology Milestones for Professionalism over a 3-year cycle.
May 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29678376/the-student-is-in-ethical-concerns-when-dermatology-patients-refuse-medical-students
#14
Michael Tassavor, Jane M Grant-Kels
No abstract text is available yet for this article.
May 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29678305/the-effect-of-cilostazol-a-phosphodiesterase-3-pde3-inhibitor-on-human-hair-growth-with-the-dual-promoting-mechanisms
#15
Hye-In Choi, Dong Young Kim, Soon-Jin Choi, Chang-Yup Shin, Sungjoo Tommy Hwang, Kyu Han Kim, Ohsang Kwon
BACKGROUND: Cilostazol, a phosphodiesterase 3 (PDE3) inhibitor, increases the intracellular level of cyclic adenosine monophosphate to cause vasodilation. Topical application of cilostazol is reported to improve local blood flow and enhance wound healing; however, its effect on human hair follicles is unknown. OBJECTIVE: The purpose of this study was to determine the effect of cilostazol on hair growth. METHODS: We investigated the expression of PDE3 in human dermal papilla cells (DPCs), outer root sheath cells (ORSCs), and hair follicles...
April 11, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29678203/quantitative-shotgun-proteomics-distinguishes-wound-healing-biomarker-signatures-in-common-carp-skin-mucus-in-response-to-ichthyophthirius-multifiliis
#16
Mona Saleh, Gokhlesh Kumar, Abdel-Azeem Abdel-Baki, Mohamed A Dkhil, Mansour El-Matbouli, Saleh Al-Quraishy
Ichthyophthirius multifiliis is a ciliated protozoan parasite recognized as one of the most pathogenic diseases of wild and cultured freshwater fish. Fish skin mucus plays a significant role against invading pathogens. However, the protein-based modulation against infection with I. multifiliis, of host fish at this barrier is unknown. Thus, we investigated the skin mucus proteome of common carp using a shotgun proteomic approach at days 1 and 9 after I. multifiliis exposure. We identified 25 differentially expressed proteins in infected carp skin mucus...
April 20, 2018: Veterinary Research
https://www.readbyqxmd.com/read/29678049/asynchronous-dermatology-teleconsultations-using-a-personal-health-record
#17
Fernando Plazzotta, Janine Arlette Sommer, Santiago Nicolás Marquez Fosser, Daniel Roberto Luna
Health information and communication technologies such as telemedicine provide alternatives for patient and physician communication. An increasing number of patients, providers and institutions are using this technologies to seek or provide health care. Asynchronous consultations requires a service of storing and forwarding health related information by the patient to the specialist physician or other healthcare provider. Dermatology is one of the major medical specialties in which telemedicine as proven benefits...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677589/generation-of-the-human-induced-pluripotent-stem-cell-hipsc-line-psmi002-a-from-a-patient-affected-by-the-jervell-and-lange-nielsen-syndrome-and-carrier-of-two-compound-heterozygous-mutations-on-the-kcnq1-gene
#18
Manuela Mura, Yee-Ki Lee, Monia Ginevrino, Rita Zappatore, Federica Pisano, Marina Boni, Federica Dagradi, Lia Crotti, Enza Maria Valente, Peter J Schwartz, Hung-Fat Tse, Massimiliano Gnecchi
We report the generation of human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a female patient carrier of the two compound heterozygous mutations c.568 C>T p.R190W (maternal allele), and c.1781 G>A p.R594Q (paternal allele) on the KCNQ1 gene, causing Jervell and Lange-Nielsen Syndrome (JLNS). To obtain hiPSCs, we used the classical approach of the four retroviruses each encoding for a reprogramming factor OCT4, SOX2, KLF4, cMYC. The obtained hiPSC clones display pluripotent stem cell characteristics, and differentiate into spontaneously beating cardiomyocytes (hiPSC-CMs)...
April 7, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29677207/sweat-glucose-and-glut2-expression-in-atopic-dermatitis-implication-for-clinical-manifestation-and-treatment
#19
Emi Ono, Hiroyuki Murota, Yuki Mori, Yoshichika Yoshioka, Yuko Nomura, Takichi Munetsugu, Hiroo Yokozeki, Ichiro Katayama
Sweat includes active components and metabolites, which are needed to maintain skin homeostasis. Component changes in sweat derived from atopic dermatitis (AD) have been reported. To investigate the influence of sweat components on the pathogenesis of AD, we performed a multifaceted assessment, including nuclear magnetic resonance spectroscopy-based metabolomic analysis, and linked these features to clinical features of AD. Distinctive properties of AD sweat are the quite-variation in protein, anti-microbial peptides and glucose concentrations...
2018: PloS One
https://www.readbyqxmd.com/read/29677018/examining-the-efficacy-of-calcium-hydroxylapatite-filler-with-integral-lidocaine-in-correcting-volume-loss-of-the-jawline-a-pilot-study
#20
Margit L W Juhász, Ellen S Marmur
BACKGROUND: Patients seek 3-dimensional volume restoration of the jawline to obtain a "defined" line. Injection of filler into the jawline is not approved by the Food and Drug Administration; however, dermatologists have injected this area with positive results, minimal adverse events, and high patient satisfaction. OBJECTIVE: This study explores the efficacy of premixed calcium hydroxylapatite filler with integral lidocaine [CaHA(+)] to correct volume defects of the jawline...
April 19, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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