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https://www.readbyqxmd.com/read/29454096/jak-stat-inhibitors-and-other-small-molecule-cytokine-antagonists-for-the-treatment-of-allergic-disease
#1
REVIEW
Michael D Howell, Carolyn Fitzsimons, Paul Smith
OBJECTIVE: To provide an overview of janus kinase (JAK), chemoattractant receptor-homologous molecule expressed on T-helper 2 cells (CRTH2), and phosphodiesterase 4 (PDE4) inhibitors in allergic disorders. DATA SOURCES: PubMed literature review. STUDY SELECTIONS: Articles included in this review discuss the emerging mechanism of action of small molecule inhibitors and their utilization in atopic dermatitis (AD), asthma, and allergic rhinitis (AR)...
February 14, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29454013/implementation-of-an-outcomes-based-curriculum-for-dermatology-clerkships-and-initial-positive-perceptions-from-faculty-and-students
#2
Karina Paci, J Alex Miles, Christopher J Sayed
No abstract text is available yet for this article.
February 14, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29453874/outcomes-of-early-dermatology-consultation-for-inpatients-diagnosed-with-cellulitis
#3
David G Li, Fan Di Xia, Hasan Khosravi, Anna K Dewan, Daniel J Pallin, Christopher W Baugh, Karl Laskowski, Cara Joyce, Arash Mostaghimi
Importance: Many inflammatory skin dermatoses mimic cellulitis (pseudocellulitis) and are treated with antibiotics and/or hospitalization, leading to unnecessary patient morbidity and substantial health care spending. Objective: To evaluate the impact of early dermatology consultation on clinical and economic outcomes associated with misdiagnosed cellulitis. Design, Setting, and Participants: This prospective cohort study enrolled patients with presumed diagnosis of cellulitis in the emergency department, in the emergency department observation unit, or within 24 hours of admission to an inpatient unit of a large urban teaching hospital between February and September 2017...
February 16, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29453872/effect-of-dermatology-consultation-on-outcomes-for-patients-with-presumed-cellulitis-a-randomized-clinical-trial
#4
Lauren N Ko, Anna C Garza-Mayers, Jessica St John, Lauren Strazzula, Priyanka Vedak, Radhika Shah, Allison S Dobry, Sowmya R Rao, Leslie W Milne, Blair Alden Parry, Daniela Kroshinsky
Importance: Each year, cellulitis leads to 650 000 hospital admissions and is estimated to cost $3.7 billion in the United States. Previous literature has demonstrated a high misdiagnosis rate for cellulitis, which results in unnecessary antibiotic use and health care cost. Objective: To determine whether dermatologic consultation decreases duration of hospital stay or intravenous antibiotic treatment duration in patients with cellulitis. Design, Setting, and Participants: This randomized clinical trial was conducted in a large urban tertiary care hospital between October 2012 and January 2017, with 1-month follow-up duration...
February 16, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29453867/inpatient-dermatologists-crucial-for-the-management-of-skin-diseases-in-hospitalized-patients
#5
Megan H Noe, Misha Rosenbach
No abstract text is available yet for this article.
February 16, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29453582/the-clinical-phenotype-of-patients-positive-for-antibodies-to-myositis-and-myositis-related-disorders
#6
S G Gofrit, H Yonath, M Lidar, Y Shoenfeld, S Kivity
Inflammatory myopathies are a clinically diverse group of diseases, in which the detection of particular autoantibodies may facilitate diagnosis, treatment, and prognosis. The aim of this report is to summarize our experience with specific autoantibody testing in patients with inflammatory myopathies. Data were collected over the last decade in the Autoimmune Center of the Sheba Medical Center, a tertiary referral hospital. Data regarding patients' positive for autoantibodies against Jo-1, PL-7, PL-12, SRP, Mi-2, Ku, and PM-Scl antigens were retrospectively collected...
February 16, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29453553/-microbiome-atopic-eczema-and-blockade-of-type-2-immunity
#7
REVIEW
M Köberle, T Biedermann
Atopic dermatitis affects roughly 20% of children and 3% of adults in Germany and other industrial countries, with an increasing prevalence. Its causality has still not been conclusively clarified but a type‑2 T‑helper cell mediated immunity reaction (type 2 immunity) dominates cutaneous inflammation. In the quest for the underlying pathogenic mechanisms and the development of improved prevention and treatment options, attention is also increasingly being paid to the influence of microbial colonization...
February 16, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29453524/a-nonsteroidal-novel-formulation-targeting-inflammatory-and-pruritus-related-mediators-modulates-experimental-allergic-contact-dermatitis
#8
William C Gordon, Virginia García López, Surjyadipta Bhattacharjee, David Rodríguez Gil, Javier Alcover Díaz, Fernando Pineda de la Losa, Ricardo Palacios Peláez, Concha Tiana Ferrer, Gabriela Silvina Bacchini, Bokkyoo Jun, Hélène Varoqui, Nicolas G Bazan
INTRODUCTION: A major clinical challenge in treating allergic contact dermatitis (ACD) is that the first line of treatment is based on the use of corticosteroids. In this study, we aimed to develop a formulation that is devoid of steroids. METHODS: We used mouse ears treated with dinitrofluorobenzene (DNFB) to induce ACD. The efficacy of the test formulation to ameliorate and to prevent induced ACD was determined. RESULTS: To treat this experimentally induced ACD, we developed a formulation containing BIPxine (a mixture of Rosa moschata and Croton lechleri (antioxidants) and Aloe vera and D-panthenol (moisturizers), and hydroglycolic solutions of disodium cromoglycate...
February 16, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29453284/structural-and-compositional-diversity-of-fibrillin-microfibrils-in-human-tissues
#9
Alexander Eckersley, Kieran T Mellody, Suzanne M Pilkington, Christopher Em Griffiths, Rachel E B Watson, Ronan O'Cualain, Clair Baldock, David Knight, Michael J Sherratt
Elastic fibres comprising fibrillin microfibrils and elastin are present in many tissues, including the skin, lung, and arteries where they confer elasticity and resilience. Although fibrillin microfibrils play distinct and tissue-specific functional roles, it is unclear whether their ultrastructure and composition differ between elastin-rich (skin) and elastin-poor (ciliary body and zonule) organs or after in vitro synthesis by cultured cells. Here, we used atomic force microscopy, which revealed that the bead morphology of fibrillin microfibrils isolated from the human eye differs from those isolated from the skin...
February 16, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29453128/generation-of-a-human-ipsc-line-from-a-patient-with-congenital-glaucoma-caused-by-mutation-in-cyp1b1-gene
#10
Arantxa Bolinches-Amorós, Dunja Lukovic, Ana Artero Castro, Marian León Rodriguez, Kunka Kamenarova, Radka Kaneva, Pavla Jendelova, Fiona Blanco-Kelly, Carmen Ayuso, Marta Cortón, Slaven Erceg
The human iPSC cell line, GLC-FiPS4F1 (ESi047-A), derived from dermal fibroblast from the patient with congenital glaucoma caused by the mutation of the gene CYP1B1, was generated by non-integrative reprogramming technology using OCT3/4, SOX2, CMYC and KLF4 reprogramming factors.
January 4, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29452960/traditionally-practiced-medicinal-plant-extracts-inhibit-the-ergosterol-biosynthesis-of-clinically-isolated-dermatophytic-pathogens
#11
M Chellappandian, M Saravanan, P Pandikumar, P Harikrishnan, K Thirugnanasambantham, S Subramanian, V I Hairul-Islam, S Ignacimuthu
OBJECTIVE: Dermatophytes are resistant to some available antibiotics. Development of new plant drugs to control drug resistant microbes is urgently needed. This study evaluates the antidermatophytic potential of 18 selected medicinal plants used by traditional healers in Theni and Virudhunagar Districts of Tamil Nadu, India. MATERIALS AND METHODS: Selected plant parts were collected, shade dried and powdered. Plant powders were extracted with ethanol and their antifungal potency was investigated against and clinical dermatophytes...
February 13, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29452045/successful-treatment-of-schamberg-s-disease-with-fractional-non-ablative-1540-nm-erbium-glass-laser
#12
Yuval Hilerowicz, Eli Sprecher, Andrea Gat, Ofir Artzi
Schamberg's disease is one of the pigmented purpuric dermatoses (PPD). PPD encompass a large and heterogeneous group of dermatologic disorders featuring purpuric lesions often located on the lower limbs. The various forms of PPD are notoriously known to be resistant to treatment. Fractional photothermolysis has been described as a successful and safe method to induce dermal remodeling. We report three patients with Schamberg's disease who were successfully treated with 4 monthly sessions of fractional non-ablative 1540 nm erbium:glass laser, with resolution of their purpuric pigmented rash lasting up to 9 months after the last treatment session...
February 16, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29451697/optimizing-case-reports-and-case-series-guidance-on-how-to-improve-quality
#13
REVIEW
I Garcia-Doval, J Albrecht, C Flohr, J Batchelor, J R Ingram
Case reports and case series remain an important part of journals and are often first to document medical breakthroughs. This article reviews their characteristics, aims and limitations. It provides information on how to increase the validity of the bedside decision-making process that these studies report, using tools such as validated outcomes and split body or n-of-1 trials. A section describing tools to improve writing of case reports and case series provides suggestions for detailed reporting and good evaluation of novelty, validity and relevance...
February 16, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29451112/-regained-freedom-for-patients-with-atopic-dermatitis-fast-and-long-term-effects-of-dupilumab
#14
T Nijsten, D J Hijnen
Dupilumab is the first and long-awaited biological for treatment of moderate to severe atopic dermatitis. In randomised clinical trials approximately 40% of patients using dupilumab 300 mg every two weeks were clear or almost clear of their eczema after 16 and 52 weeks. We now face the challenge of patient stratification to limit the budget impact of dupilumab and hope that more targeted therapies for atopic dermatitis will follow soon.
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29450975/tropoelastin-implants-that-accelerate-wound-repair
#15
Suzanne M Mithieux, Behnaz Aghaei-Ghareh-Bolagh, Leping Yan, Kekini V Kuppan, Yiwei Wang, Francia Garces-Suarez, Zhe Li, Peter K Maitz, Elizabeth A Carter, Christina Limantoro, Wojciech Chrzanowski, David Cookson, Alan Riboldi-Tunnicliffe, Clair Baldock, Kosuke Ohgo, Kristin K Kumashiro, Glenn Edwards, Anthony S Weiss
A novel, pure, synthetic material is presented that promotes the repair of full-thickness skin wounds. The active component is tropoelastin and leverages its ability to promote new blood vessel formation and its cell recruiting properties to accelerate wound repair. Key to the technology is the use of a novel heat-based, stabilized form of human tropoelastin which allows for tunable resorption. This implantable material contributes a tailored insert that can be shaped to the wound bed, where it hydrates to form a conformable protein hydrogel...
February 16, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29450833/assessing-the-importance-of-treatment-goals-in-patients-with-psoriasis-analytic-hierarchy-process-vs-likert-scales
#16
Mandy Gutknecht, Marion Danner, Marthe-Lisa Schaarschmidt, Christian Gross, Matthias Augustin
BACKGROUND: To define treatment benefit, the Patient Benefit Index contains a weighting of patient-relevant treatment goals using the Patient Needs Questionnaire, which includes a 5-point Likert scale ranging from 0 ("not important at all") to 4 ("very important"). These treatment goals have been assigned to five health dimensions. The importance of each dimension can be derived by averaging the importance ratings on the Likert scales of associated treatment goals...
February 15, 2018: Patient
https://www.readbyqxmd.com/read/29450558/jama-dermatology
#17
(no author information available yet)
No abstract text is available yet for this article.
February 1, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29450553/harvey-irma-and-maria-the-dermatologic-risks-of-hurricanes-and-floods
#18
Divya L Padmanabhan, Varun Ayyaswami, Arpan V Prabhu
No abstract text is available yet for this article.
February 1, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29450552/were-wolves-meet-dermatology
#19
Randy Atkins, Mi Hye Song, Ashley Sturgeon
No abstract text is available yet for this article.
February 1, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29450457/language-matters-dermatologists-should-speak-out-against-a-word-ban-at-centers-for-disease-control-and-prevention
#20
Misha Rosenbach, Kenneth A Katz
No abstract text is available yet for this article.
February 14, 2018: JAMA Dermatology
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