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Neonatal hemodynamics

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https://www.readbyqxmd.com/read/28302697/abstention-or-intervention-for-isolated-hypotension-in-the-first-3%C3%A2-days-of-life-in-extremely-preterm-infants-association-with-short-term-outcomes-in-the-epipage-2-cohort-study
#1
Xavier Durrmeyer, Laetitia Marchand-Martin, Raphaël Porcher, Geraldine Gascoin, Jean-Christophe Roze, Laurent Storme, Geraldine Favrais, Pierre-Yves Ancel, Gilles Cambonie
OBJECTIVE: To compare outcomes at hospital discharge for preterm infants born before 29 weeks of gestation who had at least one episode of isolated hypotension during their first 72 hours of life for which they did or did not receive antihypotensive treatment. DESIGN: Etude Epidémiologique sur les Petits Ages Gestationnels 2 (EPIPAGE 2) French national prospective population-based cohort study in 2011. SETTING: 60 neonatal intensive care units...
March 16, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28302247/symptomatic-fetal-type-cardiac-rhabdomyoma
#2
Seyma Kayali, Vehbi Dogan, Ilker Ertugrul, Senem Ouml Zg Uuml R, Utku Arman Ouml R Uuml N, Selmin Karademir, Nil Uuml Fer Arda, Murat Ko Ccedil
Rhabdomyomas are the most common primary cardiac tumors, especially seen during early periods of childhood. Fetaltype rhabdomyoma is a benign tumor described almost always in extracardiac locations. Although the natural history of the cardiac rhabdomyoma is to regress, the behaviour of the fetal-type rhabdomyomas when present in the heart is unknown with respect to its infrequency. Herein, we report a hemodynamically unstable female neonate with a single large intra-cardiac mass unresponsive to medical treatment, who underwent surgery...
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28298945/doppler-ultrasound-assessment-of-the-splanchnic-circulation-in-preterms-with-neonatal-sepsis-at-risk-for-necrotizing-enterocolitis
#3
Rania H Hashem, Yasmeen A Mansi, Nehal S Almasah, Shereen Abdelghaffar
OBJECTIVE: To evaluate the role of Doppler ultrasonography in the assessment of splanchnic circulation's hemodynamic changes in septic preterms at risk of necrotizing enterocolitis. METHODS: A total of 51 septic preterms were divided into two groups: 25 preterms with clinical signs of necrotizing enterocolitis (NEC) and 26 preterms with no clinical signs of NEC. Both groups were assessed with Doppler ultrasonography of the celiac and superior mesenteric arteries, and each septic preterm's peak systolic velocity (PSV), end-diastolic velocity (EDV), resistivity index (RI), and pulsatility index (PI) was calculated and recorded...
March 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/28293976/evolution-of-hybrid-interventions-for-congenital-heart-disease
#4
Hitesh Agrawal, Wail Alkashkari, Damien Kenny
Surgical and transcatheter interventions have seen a tremendous evolution in last three decades. Hybrid technology combines the achievements of both disciplines to bring substantial hemodynamic benefit to patients with congenital heart disease (CHD) in a minimally invasive manner. This collaboration between surgeons and interventionalists will continue to grow as the technology evolves to meet the demands of CHD patients, potentially avoiding cardiopulmonary bypass and vascular access complications as well as optimizing immediate technical outcomes with exit angiography...
March 15, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28291832/electrophysiological-and-hemodynamic-mismatch-responses-in-rats-listening-to-human-speech-syllables
#5
Mahdi Mahmoudzadeh, Ghislaine Dehaene-Lambertz, Fabrice Wallois
Speech is a complex auditory stimulus which is processed according to several time-scales. Whereas consonant discrimination is required to resolve rapid acoustic events, voice perception relies on slower cues. Humans, right from preterm ages, are particularly efficient to encode temporal cues. To compare the capacities of preterms to those observed in other mammals, we tested anesthetized adult rats by using exactly the same paradigm as that used in preterm neonates. We simultaneously recorded neural (using ECoG) and hemodynamic responses (using fNIRS) to series of human speech syllables and investigated the brain response to a change of consonant (ba vs...
2017: PloS One
https://www.readbyqxmd.com/read/28290794/-hemodynamic-derangements-in-patients-with-functional-univentricular-heart-mechanisms-of-development-possibilities-of-treatment
#6
I A Kovalev, S Ovroutski, I V Plotnikova, A A Tupikina
Heart failure (HF) is a predictable outcome of nearly all cardiovascular diseases including congenital heart diseases (CHD). A special category comprises patients with functional single ventricle (FSV) of the heart because of extreme diversity of anatomical changes of the heart and great vessels, complex mechanisms of development of HF, multistage surgical correction of the defect, presence of arrhythmias, progressive rise of pulmonary vascular resistance, etc. Prevention and treatment of HF in patients with FSV includes surgical optimization of pulmonary blood flow during neonatal period, timely staged surgical correction of the defect, pharmacotherapy, cardiac resynchronization therapy, and in severe cases mechanical cardiac support and heart transplantation...
February 2017: Kardiologiia
https://www.readbyqxmd.com/read/28285896/perinatal-changes-in-fetal-ventricular-geometry-myocardial-performance-and-cardiac-function-in-normal-term-pregnancies
#7
Olga Patey, Michael A Gatzoulis, Basky Thilaganathan, Julene S Carvalho
BACKGROUND: The fetal heart at term is exposed to an increase in hemodynamic work as a consequence of fetal growth, increased circulating volume, and alteration in loading patterns due to maturational changes in fetoplacental circulation. The extent to which these cardiovascular changes influence human fetal and neonatal cardiac adaptation has not been fully elucidated. The aim of this study was to evaluate perinatal cardiovascular changes in ventricular geometry and myocardial performance in normal term fetuses...
March 9, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28285280/effect-of-delayed-cord-clamping-on-hematocrit-and-thermal-and-hemodynamic-stability-in-preterm-neonates-a-randomized-controlled-trial
#8
Niraj Kumar Dipak, Ruchi Nimish Nanavat, Nand Kishore Kabra, Anita Srinivasan, Anitha Ananthan
OBJECTIVE: To evaluate the short term clinical effects of delayed cord clamping in preterm neonates. DESIGN: Randomized controlled trial. SETTING: A tertiary care neonatal unit from October 2013 to September 2014. PARTICIPANTS: 78 mothers with preterm labor between 27 to 316/7 weeks gestation. INTERVENTION: Early cord clamping (10 s), delayed cord clamping (60 s) or delayed cord clamping (60 s) along with intramuscular ergometrine (500 µg) administered to the mother...
February 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28276534/non-invasive-assessment-of-cerebral-blood-flow-and-oxygen-metabolism-in-neonates-during-hypothermic-cardiopulmonary-bypass-feasibility-and-clinical-implications
#9
Silvina L Ferradal, Koichi Yuki, Rutvi Vyas, Christopher G Ha, Francesca Yi, Christian Stopp, David Wypij, Henry H Cheng, Jane W Newburger, Aditya K Kaza, Maria A Franceschini, Barry D Kussman, P Ellen Grant
The neonatal brain is extremely vulnerable to injury during periods of hypoxia and/or ischemia. Risk of brain injury is increased during neonatal cardiac surgery, where pre-existing hemodynamic instability and metabolic abnormalities are combined with long periods of low cerebral blood flow and/or circulatory arrest. Our understanding of events associated with cerebral hypoxia-ischemia during cardiopulmonary bypass (CPB) remains limited, largely due to inadequate tools to quantify cerebral oxygen delivery and consumption non-invasively and in real-time...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28264088/association-of-patent-ductus-arteriosus-ligation-with-death-or-neurodevelopmental-impairment-among-extremely-preterm-infants
#10
Dany E Weisz, Lucia Mirea, Erin Rosenberg, Maximus Jang, Linh Ly, Paige T Church, Edmond Kelly, S Joseph Kim, Amish Jain, Patrick J McNamara, Prakesh S Shah
Importance: Observational studies have associated patent ductus arteriosus (PDA) ligation among preterm infants with adverse neonatal outcomes and neurodevelopmental impairment in early childhood, with a resultant secular trend away from surgical treatment. However, to our knowledge, studies have inadequately addressed sources of residual bias, including survival bias and major neonatal morbidities arising before exposure to ligation. Objective: Evaluate the association between PDA ligation vs medical management and neonatal and neurodevelopmental outcomes...
March 6, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28251324/middle-cerebral-artery-aneurysm-rupture-in-a-neonate-with-interrupted-aortic-arch-case-report
#11
Joaquin Hidalgo, James Charles Dickerson, Brandon Burnsed, Ali Luqman, James Mason Shiflett
INTRODUCTION: Arterial cerebral aneurysms in the neonatal population are rare, and while the association of interrupted aortic arch and intracranial aneurysm has been reported in the adult and pediatric population (three cases each), to date, it has not been reported in the neonate. CASE REPORT: We report the case of a 26-day-old girl who presented with a generalized seizure 2 weeks after undergoing congenital heart surgery. Head CT revealed diffuse SAH with a 1...
March 1, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28238152/myocardial-infarction-in-neonates-a-review-of-an-entity-with-significant-morbidity-and-mortality
#12
REVIEW
Koyelle Papneja, Anthony K Chan, Tapas K Mondal, Bosco Paes
Coronary artery disease is a global problem with high mortality rates and significant residual sequelae that affect long-term quality of life. Myocardial infarction (MI) in neonates is a recognized, uncommon entity, but the incidence and broad spectrum of the disease is unknown and likely underestimated due to limited reporting which in the majority is confined to acute ischemic events. The challenges involve clinical diagnosis which masquerades in the early phase as non-specific symptoms and signs that are commonly found in a host of neonatal disorders...
February 25, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28236342/maternal-cardiac-output-in-early-labour-a-possible-link-with-obstetrics-risks
#13
Herbert Valensise, Grazia Maria Tiralongo, Ilaria Pisani, Daniele Farsetti, Damiano Lo Presti, Giulia Gagliardi, Ripalta Marica Basile, Gian Paolo Novelli, Barbara Vasapollo
OBJECTIVE: to verify if the hemodynamic assessment of "low risk" pregnant women at term can improve the identification of patients with a maternal or foetal-neonatal complication during labour MATERIALS AND METHODS: a prospective observational study was conducted on 77 pregnant women at term with diagnosis of initial labour. We obtained haemodynamic indices using the USCOM(®) system. Patients were followed until the end of labour to check for foetal-neonatal and maternal outcomes. RESULTS: Eleven patients (14...
February 25, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28221717/cerebral-and-lung-effects-of-a-new-generation-synthetic-surfactant-with-sp-b-and-sp-c-analogs-in-preterm-lambs
#14
Carmen Rey-Santano, Victoria E Mielgo, Xabier Murgia, Miguel Angel Gomez-Solaetxe, Fabrizio Salomone, Federico Bianco, Nicola Pelizzi, Begoña Loureiro, Jon López de Heredia Y Goya
BACKGROUND: Though natural surfactants (SF) are clinically superior to protein-free synthetic preparations, CHF-5633, a synthetic SF containing SP-B and SP-C analog peptides is a potential alternative to natural SF for treating neonatal respiratory distress syndrome (RDS). Nevertheless, information is lacking regarding the safety of this new treatment for the neonatal brain. We sought to compare the cerebral and pulmonary effects of this new synthetic surfactant (CHF5633) with those of natural porcine surfactant (Cursosurf) in premature lambs with RDS...
February 21, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28206993/hemodynamic-effects-of-sodium-bicarbonate-administration
#15
A C Katheria, M K Brown, K Hassan, D M Poeltler, D A Patel, V K Brown, J B Sauberan
OBJECTIVE: To describe the hemodynamic changes that occur with sodium bicarbonate (NaHCO3) administration in premature neonates. STUDY DESIGN: This retrospective study included premature neonates 23 to 31+6 weeks of gestational age who underwent continuous cardiac and cerebral monitoring as participants in prospective trials at our institution, and who received NaHCO3 infused over 30 min in the first 24 h of life. Blood pressure (BP), heart rate, cardiac output (CO), SpO2 and cerebral oximetry (StO2) were captured every 2 s...
February 16, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28176246/isorhamnetin-protects-against-cardiac-hypertrophy-through-blocking-pi3k-akt-pathway
#16
Lu Gao, Rui Yao, Yuzhou Liu, Zheng Wang, Zhen Huang, Binbin Du, Dianhong Zhang, Leiming Wu, Lili Xiao, Yanzhou Zhang
Isorhamnetin, a flavonoid compound extracted from the Chinese herb Hippophae rhamnoides L., is well known for its anti-inflammatory, anti-oxidative, anti-adipogenic, anti-proliferative, and anti-tumor activities. However, the role of isorhamnetin in cardiac hypertrophy has not been reported. The aims of the present study were to find whether isorhamnetin could alleviate cardiac hypertrophy and to define the underlying molecular mechanisms. Here, we investigated the effects of isorhamnetin (100 mg/kg/day) on cardiac hypertrophy induced by aortic banding in mice...
February 7, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28168185/optimal-chest-compression-rate-and-compression-to-ventilation-ratio-in-delivery-room-resuscitation-evidence-from-newborn-piglets-and-neonatal-manikins
#17
REVIEW
Anne Lee Solevåg, Georg M Schmölzer
Cardiopulmonary resuscitation (CPR) duration until return of spontaneous circulation (ROSC) influences survival and neurologic outcomes after delivery room (DR) CPR. High quality chest compressions (CC) improve cerebral and myocardial perfusion. Improved myocardial perfusion increases the likelihood of a faster ROSC. Thus, optimizing CC quality may improve outcomes both by preserving cerebral blood flow during CPR and by reducing the recovery time. CC quality is determined by rate, CC to ventilation (C:V) ratio, and applied force, which are influenced by the CC provider...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28163448/-hemodynamic-vice-of-the-right-sided-ascending-vertical-vein-in-the-setting-of-supracardiac-total-anomalous-pulmonary-venous-connection-in-a-neonate-anatomic-embryological-correlation
#18
Atul Achyut Kalantre, Bhavik Champaneri, Brijesh Kottayil, Balu Vaidyanathan
No abstract text is available yet for this article.
January 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28152330/randomized-controlled-trial-on-effect-of-intermittent-early-versus-late-kangaroo-mother-care-on-human-milk-feeding-in-low-birth-weight-neonates
#19
Dhaarani Jayaraman, Kanya Mukhopadhyay, Anil Kumar Bhalla, Lakhbir Kaur Dhaliwal
BACKGROUND: Breastfeeding at discharge among sick low-birth-weight (LBW) infants is low despite counseling and intervention like kangaroo mother care (KMC). Research aim: The aim was to study the effects of early initiation of KMC on exclusive human milk feeding, growth, mortality, and morbidities in LBW neonates compared with late initiation of KMC during the hospital stay and postdischarge. METHODS: A randomized controlled trial was conducted in level 2 and 3 areas of a tertiary care neonatal unit over 15 months...
February 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28110270/assessment-of-neonatal-pain-during-heel-prick-lancet-vs-needle-a-randomized-controlled-study
#20
Carl Britto, Suman P N Rao
BACKGROUND: Heel prick is a frequent painful procedure in newborns. A lancet or a 26-gauge needle is used for a heel prick in India. OBJECTIVE: To compare the pain caused by heel prick with a lancet or a 26-gauge needle in newborns admitted in the neonatal intensive care unit (NICU) using the preterm infant pain profile (PIPP). METHODS: This randomized controlled trial was conducted over 2 months in a Level III NICU with a sample size of 40 subjects (20 in each group), which was required for the study to have a power of 80% with an alpha error of 0...
January 21, 2017: Journal of Tropical Pediatrics
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