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https://www.readbyqxmd.com/read/29656592/the-applicability-of-furfuryl-gelatin-as-a-novel-bioink-for-tissue-engineering-applications
#1
Shweta AnilKumar, Shane C Allen, Nishat Tasnim, Tahmina Akter, Shinhye Park, Alok Kumar, Munmun Chattopadhyay, Yoshihiro Ito, Laura J Suggs, Binata Joddar
Three-dimensional bioprinting is an innovative technique in tissue engineering, to create layer-by-layer structures, required for mimicking body tissues. However, synthetic bioinks do not generally possess high printability and biocompatibility at the same time. So, there is an urgent need for naturally derived bioinks that can exhibit such optimized properties. We used furfuryl-gelatin as a novel, visible-light crosslinkable bioink for fabricating cell-laden structures with high viability. Hyaluronic acid was added as a viscosity enhancer and either Rose Bengal or Riboflavin was used as a visible-light crosslinker...
April 15, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29656392/epigenetic-modifications-preserve-the-hyperaccumulator-noccaea-caerulescens-from-ni-geno-toxicity
#2
Mariolina Gullì, Laura Marchi, Rosaria Fragni, Annamaria Buschini, Giovanna Visioli
The Ni hyperaccumulator Noccaea caerulescens has adapted to live in a naturally stressed environment, evolving a complex pattern of traits to cope with adverse conditions. Evidence is accumulating regarding the important role of epigenetic modifications in regulating plant responses to stress. In this study, we present data from the natural "open-field" adaptation of the Ni hyperaccumulator N. caerulescens to serpentine soil and provide the first evidence of the involvement of epigenetic changes in response to the high Ni content present in plant leaves...
April 15, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29656328/human-colostrum-action-against-giardia-lamblia-infection-influenced-by-hormones-and-advanced-maternal-age
#3
Queli Lisiane Castro Pereira, Cristiane de Castro Pernet Hara, Rubian Trindade Silva Fernandes, Danny Laura Gomes Fagundes, Aline do Carmo França-Botelho, Maria Aparecida Gomes, Eduardo Luzía França, Adenilda Cristina Honorio-França
Children are more susceptible to Giardia lamblia infection. Cells and hormones contained in human colostrum have an immunoprotective action against giardiasis, but the effects of advanced maternal age on these components are poorly understood. This study analyzed the colostrum of older women to determine melatonin and cortisol levels besides the participation of these hormones on the functional activity of phagocytes against G. lamblia. Colostrum samples were collected from younger (18 to 35 years old) and older (over 36 years old) lactating women...
April 14, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29656314/-174-g-c-il-6-polymorphism-and-primary-iron-overload-in-male-patients
#4
Walter F Tetzlaff, Tomás Meroño, Eliana E Botta, Maximiliano E Martín, Patricia B Sorroche, Laura E Boero, Marcelo Castro, Gustavo D Frechtel, Jorge Rey, Jorge Daruich, Gloria E Cerrone, Fernando Brites
Primary iron overload (IO) is commonly associated with mutations in the hereditary hemochromatosis gene (HFE). Nonetheless, other genetic variants may influence the development of IO beyond HFE mutations. There is a single nucleotide polymorphism (SNP) at - 174 G>C of the interleukin (IL)-6 gene which might be associated with primary IO. Our aim was to study the association between the SNP - 174 G>C gene promoter of IL-6 and primary IO in middle-aged male patients. We studied 37 men with primary IO diagnosed by liver histology...
April 14, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29656245/individual-differences-in-socioemotional-sensitivity-are-an-index-of-salience-network-function
#5
Gianina Toller, Jesse Brown, Marc Sollberger, Suzanne M Shdo, Laura Bouvet, Paul Sukhanov, William W Seeley, Bruce L Miller, Katherine P Rankin
Connectivity in intrinsically connected networks (ICNs) may predict individual differences in cognition and behavior. The drastic alterations in socioemotional awareness of patients with behavioral variant frontotemporal dementia (bvFTD) are presumed to arise from changes in one such ICN, the salience network (SN). We examined how individual differences in SN connectivity are reflected in overt social behavior in healthy individuals and patients, both to provide neuroscientific insight into this key brain-behavior relationship, and to provide a practical tool to diagnose patients with early bvFTD...
February 27, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29655957/ectopic-cushing-syndrome-report-of-9-cases
#6
Marta Araujo Castro, Nuria Palacios García, Javier Aller Pardo, Cristina Izquierdo Alvarez, Laura Armengod Grao, Javier Estrada García
INTRODUCTION: Ectopic Cushing's syndrome (ECS) is a rare condition caused by ACTH secretion by extrapituitary tumors. Its low frequency makes it difficult to acquire experience in its management. The aim of this study was to describe patients with ECS seen at the endocrinology department of a tertiary hospital over 15 years. METHODS: This was a retrospective study of the clinical, biochemical and radiographic data, treatment, and course of patients with ECS seen from 2000 to 2015...
April 11, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29655939/improving-the-signal-detection-accuracy-of-functional-magnetic-resonance-imaging
#7
Niels Janssen, Juan A Hernández-Cabrera, Laura Ezama Foronda
A major drawback of functional Magnetic Resonance Imaging (fMRI) concerns the lack of detection accuracy of the measured signal. Although this limitation stems in part from the neuro-vascular nature of the fMRI signal, it also reflects particular methodological decisions in the fMRI data analysis pathway. Here we show that the signal detection accuracy of fMRI is affected by the specific way in which whole-brain volumes are created from individually acquired brain slices, and by the method of statistically extracting signals from the sampled data...
April 12, 2018: NeuroImage
https://www.readbyqxmd.com/read/29655883/evaluating-surgical-coaching-a-mixed-methods-approach-reveals-more-than-surveys-alone
#8
Laura M Mazer, Yue-Yung Hu, Alexander F Arriaga, Caprice C Greenberg, Stuart R Lipsitz, Atul A Gawande, Douglas S Smink, Steven J Yule
OBJECTIVE: Traditionally, surgical educators have relied upon participant survey data for the evaluation of educational interventions. However, the ability of such subjective data to completely evaluate an intervention is limited. Our objective was to compare resident and attending surgeons' self-assessments of coaching sessions from surveys with independent observations from analysis of intraoperative and postoperative coaching transcripts. DESIGN: Senior residents were video-recorded operating...
April 11, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29655837/outcomes-of-early-liver-transplantation-for-patients-with-severe-alcoholic-hepatitis
#9
Brian P Lee, Neil Mehta, Laura Platt, Ahmet Gurakar, John P Rice, Michael R Lucey, Gene Y Im, George Therapondos, Hyosun Han, David W Victor, Oren K Fix, Lisanne Dinges, Deepti Dronamraju, Christine Hsu, Michael D Voigt, Mary E Rinella, Haripriya Maddur, Sheila Eswaran, Jessica Hause, David Foley, R Mark Ghobrial, Jennifer L Dodge, Zhiping Li, Norah A Terrault
BACKGROUND & AIMS: The American Consortium of Early Liver Transplantation (LT) for Alcoholic Hepatitis comprises 12 centers from 8 United Network for Organ Sharing regions studying early LT (without mandated period of sobriety) for patients with severe alcoholic hepatitis (AH). We analyzed outcomes of these patients. METHODS: We performed a retrospective study of consecutive patients with a diagnosis of severe AH and no prior diagnosis of liver disease or episodes of AH, who underwent LT before 6 months of abstinence from 2006 through 2017 at 12 centers...
April 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29655834/metformin-use-associates-with-longer-progression-free-survival-of-patients-with-diabetes-and-pancreatic-neuroendocrine-tumors-receiving-everolimus-and-or-somatostatin-analogues
#10
Sara Pusceddu, Claudio Vernieri, Massimo Di Maio, Riccardo Marconcini, Francesca Spada, Sara Massironi, Toni Ibrahim, Maria Pia Brizzi, Davide Campana, Antongiulio Faggiano, Dario Giuffrida, Maria Rinzivillo, Sara Cingarlini, Francesca Aroldi, Lorenzo Antonuzzo, Rossana Berardi, Laura Catena, Chiara De Divitiis, Paola Ermacora, Vittorio Perfetti, Annalisa Fontana, Paola Razzore, Carlo Carnaghi, Maria Vittoria Davì, Carolina Cauchi, Marilina Duro, Sergio Ricci, Nicola Fazio, Federica Cavalcoli, Alberto Bongiovanni, Anna La Salvia, Nicole Brighi, Annamaria Colao, Ivana Puliafito, Francesco Panzuto, Silvia Ortolani, Alberto Zaniboni, Francesco Di Costanzo, Mariangela Torniai, Emilio Bajetta, Salvatore Tafuto, Silvio Ken Garattini, Daniela Femia, Natalie Prinzi, Laura Concas, Giuseppe Lo Russo, Massimo Milione, Luca Giacomelli, Roberto Buzzoni, Gianfranco Delle Fave, Vincenzo Mazzaferro, Filippo de Braud
BACKGROUND & AIMS: Metformin seems to have anti-cancer effects. However, it is not clear whether use of glycemia and metformin affect outcomes of patients with advanced pancreatic neuroendocrine tumors (pNETs). We investigated the association between glycemia and progression-free survival (PFS) of patients with NETs treated with everolimus and/or somatostatin analogues, as well as the association between metformin use and PFS time. METHODS: We performed a retrospective analysis of 445 patients with advanced pNET treated at 24 medical centers in Italy, from 1999 through 2015...
April 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29655764/anomalous-pulmonary-venous-drainage-and-pulmonary-vein-stenosis
#11
Laura Díaz-Chirón, Helena Cigarrán, Jacobo Silva
No abstract text is available yet for this article.
April 11, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29655657/the-mindful-eating-behavior-scale-development-and-psychometric-properties-in-a-sample-of-dutch-adults-aged-55-years-and-older
#12
Laura H H Winkens, Tatjana van Strien, Juan Ramón Barrada, Ingeborg A Brouwer, Brenda W J H Penninx, Marjolein Visser
BACKGROUND: Earlier scales on mindful eating do not measure mindful eating independent from emotional or external eating, or mindful eating in common situations. OBJECTIVE: The objective was to develop a new instrument to measure the attention element of mindful eating, the Mindful Eating Behavior Scale (MEBS), and to compute the internal structure, reliabilities, and convergent validity of this scale. DESIGN: A cross-sectional ancillary study within the Longitudinal Aging Study Amsterdam was conducted between fall 2014 and spring 2015...
April 11, 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29655633/vaccine-technology-vi-innovative-and-integrated-approaches-in-vaccine-development
#13
EDITORIAL
Laura A Palomares, Tarit K Mukhopadhyay, Yvonne Genzel, Linda H L Lua, Manon M J Cox
No abstract text is available yet for this article.
April 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29655598/individual-differences-in-the-energizing-effects-of-caffeine-on-effort-based-decision-making-tests-in-rats
#14
Noemí SanMiguel, Marta Pardo, Carla Carratalá-Ros, Laura López-Cruz, John D Salamone, Mercè Correa
Motivated behavior is characterized by activation and high work output. Nucleus accumbens (Nacb) modulates behavioral activation and effort-based decision-making. Caffeine is widely consumed because of its energizing properties. This methylxanthine is a non-selective adenosine A1 /A2A receptor antagonist. Adenosine receptors are highly concentrated in Nacb. Adenosine agonists injected into Nacb, shift preference towards low effort alternatives. The present studies characterized effort-related effects of caffeine in a concurrent progressive ratio (PROG)/free reinforcer choice procedure that requires high levels of work output, and generates great variability among different animals...
April 12, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29655507/response-to-name-and-its-value-for-the-early-detection-of-developmental-disorders-insights-from-autism-spectrum-disorder-rett-syndrome-and-fragile-x-syndrome-a-perspectives-paper
#15
Dajie Zhang, Laura Roche, Katrin D Bartl-Pokorny, Magdalena Krieber, Laurie McLay, Sven Bölte, Luise Poustka, Jeff Sigafoos, Markus Gugatschka, Christa Einspieler, Peter B Marschik
BACKGROUND: Responding to one's own name (RtN) has been reported as atypical in children with developmental disorders, yet comparative studies on RtN across syndromes are rare. AIMS: We aim to (a) overview the literature on RtN in different developmental disorders during the first 24 months of life, and (b) report comparative data on RtN across syndromes. METHODS AND PROCEDURES: In Part 1, a literature search, focusing on RtN in children during the first 24 months of life with developmental disorders, identified 23 relevant studies...
April 11, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29655453/measuring-clinical-treatment-response-in-myasthenia-gravis
#16
REVIEW
Carolina Barnett, Laura Herbelin, Mazen M Dimachkie, Richard J Barohn
In this article we provide an overview of health-related outcome measurement-to better understand what different outcomes used in myasthenia actually measure-and to provide some guidance when choosing measures based on the clinical context and question. In myasthenia, the most commonly used outcome measures are aimed at assessing the signs and symptoms. In this review, we provide a summary of the most commonly used outcome measures. We discuss instruments that gauge disease overall health impact, such as on disability and quality of life...
May 2018: Neurologic Clinics
https://www.readbyqxmd.com/read/29655409/orthodontic-tooth-movement-the-biology-and-clinical-implications
#17
REVIEW
Yina Li, Laura A Jacox, Shannyn H Little, Ching-Chang Ko
Orthodontic tooth movement relies on coordinated tissue resorption and formation in the surrounding bone and periodontal ligament. Tooth loading causes local hypoxia and fluid flow, initiating an aseptic inflammatory cascade culminating in osteoclast resorption in areas of compression and osteoblast deposition in areas of tension. Compression and tension are associated with particular signaling factors, establishing local gradients to regulate remodeling of the bone and periodontal ligament for tooth displacement...
April 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29653229/the-splicing-of-tiny-introns-of-paramecium-is-controlled-by-mago
#18
Julia Contreras, Victoria Begley, Laura Marsella, Eduardo Villalobo
The exon junction complex (EJC) is a key element of the splicing machinery. The EJC core is composed of eIF4A3, MAGO, Y14 and MLN51. Few accessory proteins, such as CWC22 or UPF3, bind transiently to the EJC. The EJC has been implicated in the control of the splicing of long introns. To ascertain whether the EJC controls the splicing of short introns, we used Paramecium tetraurelia as a model organism, since it has thousands of very tiny introns. To elucidate whether EJC affects intron splicing in P. tetraurelia, we searched for EJC protein-coding genes, and silenced those genes coding for eIF4A3, MAGO and CWC22...
April 10, 2018: Gene
https://www.readbyqxmd.com/read/29653047/understanding-electrochemically-activated-persulfate-and-its-application-to-ciprofloxacin-abatement
#19
Laura W Matzek, Matthew J Tipton, Abigail T Farmer, Andrew Steen, Kimberly E Carter
This study offers significant insight into the roles anodic and cathodic processes play in electrochemically-activated persulfate (EAP) and screens EAP as a viable technique for ciprofloxacin degradation in wastewater. Sulfate radical formation at a boron-doped diamond anode and persulfate activation at a graphite cathode were experimentally elucidated using different electrolytes and electrochemical set-ups. Rapid ciprofloxacin transformation occurred via pseudo-first order mechanisms in persulfate electrolyte, reaching 84% removal in 120 minutes using EAP...
April 13, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29653023/%C3%AE-aminobutyric-acid-quantification-in-small-volume-biological-samples-through-enzymatically-induced-electrochemiluminescence
#20
Juan Carlos Salazar-Sánchez, Alberto Morales-Villagrán, Silvia Josefina López-Pérez, Kenia Pardo-Peña, Fridha Villalpando-Vargas, Laura Medina-Ceja
γ-Aminobutyric acid (GABA) is a well-known neurotransmitter that regulates inhibitory neurotransmission in the mammalian central nervous system and participates in several processes outside the brain. A reliable quantification method is needed to determine its role in different physiological and pathological conditions. However, GABA measurements have several challenges because GABA is neither fluorescent nor electroactive, and it is difficult to detect using enzymatic reactions because no oxidases or dehydrogenases have been identified...
April 13, 2018: Luminescence: the Journal of Biological and Chemical Luminescence
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