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https://www.readbyqxmd.com/read/28735525/oxygen-tension-independent-protection-against-hypoxic-cell-killing-in-rat-liver-by-low-sodium
#1
Andrea Ferrigno, Laura G Di Pasqua, Clarissa Berardo, Veronica Siciliano, Plinio Richelmi, Mariapia Vairetti
The role of Na+ in hypoxic injury was evaluated by a time-course analysis of damage in isolated livers perfused with N2-saturated buffer containing standard (143 mM) or low (25 mM) Na+ levels. Trypan blue uptake was used to detect non-viable cells. Under hypoxia with standard-Na+, trypan blue uptake began at the border between pericentral areas and periportal regions and increased in the latter zone; using a low-Na+ buffer, no trypan blue zonation occurred but a homogenous distribution of dye was found associated with sinusoidal endothelial cell (SEC) staining...
May 30, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/28735294/comparing-family-based-treatment-with-parent-focused-treatment-for-adolescent-anorexia-nervosa
#2
Susan Walker, Ramya Srinivasan, Laura Fialko, Erica Cini
No abstract text is available yet for this article.
July 22, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/28735152/a-systematic-review-of-cardiovascular-emergency-department-visits-hospital-admissions-and-mortality-associated-with-ambient-black-carbon
#3
REVIEW
Thomas J Luben, Jennifer L Nichols, Steven J Dutton, Ellen Kirrane, Elizabeth O Owens, Laura Datko-Williams, Meagan Madden, Jason D Sacks
BACKGROUND: Black carbon (BC) is a ubiquitous component of particulate matter (PM) emitted from combustion-related sources and is associated with a number of health outcomes. OBJECTIVES: We conducted a systematic review to evaluate the potential for cardiovascular morbidity and mortality following exposure to ambient BC, or the related component elemental carbon (EC), in the context of what is already known about the associations between exposure to fine particulate matter (PM2...
July 20, 2017: Environment International
https://www.readbyqxmd.com/read/28735150/inverse-relationship-between-urban-green-space-and-childhood-autism-in-california-elementary-school-districts
#4
Jianyong Wu, Laura Jackson
Green space has a variety of health benefits. However, little is known about its impact on autism, the fastest-growing neurodevelopmental disorder in children. This study examined the relationship between green space and childhood autism prevalence. Autism count data in 2010 were obtained for 543 of ~560 public elementary school districts in California. Multiple types of green space were measured in each school district, including percentages of forest, grassland, and average tree canopy and near-road tree canopy...
July 20, 2017: Environment International
https://www.readbyqxmd.com/read/28735109/design-and-rationale-for-a-real-world-observational-cohort-of-patients-with-nonalcoholic-fatty-liver-disease-the-target-nash-study
#5
A Sidney Barritt, Norman Gitlin, Samuel Klein, Anna S Lok, Rohit Loomba, Laura Malahias, Margaret Powell, Miriam B Vos, L Michael Weiss, Kenneth Cusi, Brent A Neuschwander-Tetri, Arun Sanyal
Nonalcoholic fatty liver disease (NAFLD) is highly prevalent and can lead to cirrhosis, hepatocellular carcinoma, and end-stage liver disease. NAFLD comprises the spectrum from simple steatosis (nonalcoholic fatty liver, NAFL), to steatosis with inflammation (nonalcoholic steatohepatitis, NASH). Current primary therapy recommended for NAFLD is weight loss induced by lifestyle modification. The difficulty in achieving this has led to robust pharmacological therapy development. While new drugs may show efficacy in selected phase II/III clinical trial populations, their real-world effectiveness is unknown...
July 19, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28735070/suppression-of-the-atp-binding-cassette-transporter-abcc4-impairs-neuroblastoma-tumour-growth-and-sensitises-to-irinotecan-in%C3%A2-vivo
#6
Jayne Murray, Emanuele Valli, Denise M T Yu, Alan M Truong, Andrew J Gifford, Georgina L Eden, Laura D Gamble, Kimberley M Hanssen, Claudia L Flemming, Alvin Tan, Amanda Tivnan, Sophie Allan, Federica Saletta, Leanna Cheung, Michelle Ruhle, John D Schuetz, Michelle J Henderson, Jennifer A Byrne, Murray D Norris, Michelle Haber, Jamie I Fletcher
The ATP-binding cassette transporter ABCC4 (multidrug resistance protein 4, MRP4) mRNA level is a strong predictor of poor clinical outcome in neuroblastoma which may relate to its export of endogenous signalling molecules and chemotherapeutic agents. We sought to determine whether ABCC4 contributes to development, growth and drug response in neuroblastoma in vivo. In neuroblastoma patients, high ABCC4 protein levels were associated with reduced overall survival. Inducible knockdown of ABCC4 strongly inhibited the growth of human neuroblastoma cells in vitro and impaired the growth of neuroblastoma xenografts...
July 20, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28735028/protein-only-antimicrobial-peptide-containing-recombinant-nanoparticles-with-inherent-built-in-antibacterial-activity
#7
Naroa Serna, Laura Sánchez-García, Alejandro Sánchez-Chardi, Ugutz Unzueta, Mónica Roldán, Ramón Mangues, Esther Vázquez, Antonio Villaverde
The emergence of bacterial antibiotic resistances is a serious concern in human and animal health. In this context, naturally occurring cationic antimicrobial peptides (AMPs) might play a main role in a next generation of drugs against bacterial infections. Taking an innovative approach to design self-organizing functional proteins, we have generated here protein-only nanoparticles with intrinsic AMP microbicide activity. Using a recombinant version of the GWH1 antimicrobial peptide as building block, these materials show a wide antibacterial activity spectrum in absence of detectable toxicity on mammalian cells...
July 19, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28734976/structural-basis-of-the-substrate-specificity-and-instability-in-solution-of-a-glycosidase-from-lactobacillus-plantarum
#8
Iván Acebrón, Laura Plaza-Vinuesa, Blanca de Las Rivas, Rosario Muñoz, J Cumella, F Sánchez-Sancho, José Miguel Mancheño
Statistics from structural genomics initiatives reveal that around 50-55% of the expressed, non-membrane proteins cannot be purified and therefore structurally characterized due to solubility problems, which emphasized protein solubility as one of the most serious concerns in structural biology projects. Lactobacillus plantarum CECT 748(T) produces an aggregation-prone glycosidase (LpBgl) that we crystallized previously. However, this result could not be reproduced due to protein instability and therefore further high-resolution structural analyses of LpBgl were impeded...
July 19, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28734937/longitudinal-examination-of-resilience-after-traumatic-brain-injury-a-traumatic-brain-injury-model-systems-study
#9
Jennifer H Marwitz, Adam P Sima, Jeffrey S Kreutzer, Laura E Dreer, Thomas F Bergquist, Ross Zafonte, Douglas Johnson-Greene, Elizabeth R Felix
OBJECTIVE: To evaluate the trajectory of resilience during the first year following a moderate-severe TBI, factors associated with resilience at 3, 6 and 12-months post-injury, and changing relationships over time between resilience and other factors. DESIGN: Longitudinal analysis of an observational cohort. SETTING: Five inpatient rehabilitation centers. PARTICIPANTS: Patients with TBI (N = 195) enrolled in the resilience module of the TBI Model Systems study with data collected at 3, 6, and 12-month follow-up...
July 19, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28734657/exercise-performance-and-22q11-2-deletion-status-affect-quality-of-life-in-tetralogy-of-fallot
#10
Elizabeth Goldmuntz, Amy Cassedy, Laura Mercer-Rosa, Mark A Fogel, Stephen M Paridon, Bradley S Marino
OBJECTIVE: To identify mediators of health status and quality of life (QOL) in children and adolescents aged 8-18 years old following surgical repair for tetralogy of Fallot (TOF), including resource use, exercise performance, and 22q11.2 deletion status. STUDY DESIGN: We performed a corollary study to a cross-sectional analysis of subjects following repair for TOF that completed cardiac magnetic resonance imaging, cardiopulmonary exercise tests, and instruments assessing health status and QOL...
July 19, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28734454/patient-specific-ventricular-access-site-selection-for-the-neochord-mitral-valve-repair-procedure
#11
Andrea Colli, Eleonora Bizzotto, Erica Manzan, Laura Besola, Nicola Pradegan, Roberto Bellu, Demetrio Pittarello, Gino Gerosa
Selecting the ventricular access site on the basis of mitral valve anatomy improves the outcomes for a subgroup of patients undergoing the transapical echocardiographically guided NeoChord (NeoChord, Inc, St. Louis Park, MN) repair procedure to correct mitral regurgitation and who have a leaflet-to-annulus index lower than the recommended efficacy threshold of 1.25.
August 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28734322/association-between-childhood-to-adolescent-attention-deficit-hyperactivity-disorder-symptom-trajectories-and-late-adolescent-disordered-eating
#12
Zeynep Yilmaz, Kristin N Javaras, Jessica H Baker, Laura M Thornton, Paul Lichtenstein, Cynthia M Bulik, Henrik Larsson
PURPOSE: Disordered eating is more prevalent among adolescents with attention deficit/hyperactivity disorder. Both inattention and hyperactivity/impulsivity symptoms show strong associations with disordered eating, but few investigations of these associations have been longitudinal. Thus, we examined the effect of childhood to adolescent inattention and hyperactivity/impulsivity symptom trajectories on late adolescent disordered eating. METHODS: We used growth mixture modeling to identify distinct inattention and hyperactivity/impulsivity symptom trajectories (called "classes") across three time points (ages 8-9, 13-14, and 16-17 years) in the Swedish Twin study of CHild and Adolescent Development...
August 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28734065/fdg-pet-dopamine-transporter-spect-and-olfaction-combining-biomarkers-in-rem-sleep-behavior-disorder
#13
Sanne K Meles, David Vadasz, Remco J Renken, Elisabeth Sittig-Wiegand, Geert Mayer, Candan Depboylu, Kathrin Reetz, Sebastiaan Overeem, Angelique Pijpers, Fransje E Reesink, Teus van Laar, Lisette Heinen, Laura K Teune, Helmut Höffken, Marcus Luster, Karl Kesper, Sofie M Adriaanse, Jan Booij, Klaus L Leenders, Wolfgang H Oertel
BACKGROUND: Idiopathic REM sleep behavior disorder is a prodromal stage of Parkinson's disease and dementia with Lewy bodies. Hyposmia, reduced dopamine transporter binding, and expression of the brain metabolic PD-related pattern were each associated with increased risk of conversion to PD. The objective of this study was to study the relationship between the PD-related pattern, dopamine transporter binding, and olfaction in idiopathic REM sleep behavior disorder. METHODS: In this cross-sectional study, 21 idiopathic REM sleep behavior disorder subjects underwent (18) F-fluorodeoxyglucose PET, dopamine transporter imaging, and olfactory testing...
July 22, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28733994/seasonal-recruitment-and-survival-strategies-of-palisada-cervicornis-comb-nov-ceramiales-rhodophyta-in-coral-reefs
#14
Ligia Collado-Vides, Alain Duran, Elizabeth Armenis, Valéria Cassano, Deron Burkepile, Andrew A Shantz, Laura Palma, Jhoana Díaz-Larrea, Abel Sentíes, Mutue Toyota Fujii
As marine tropical ecosystems deteriorate and lose biodiversity, their communities are shifting to being dominated by a few species, altering ecosystem's functioning and services. Macroalgae are becoming dominant on coral reefs, and are frequently observed outcompeting corals. Turf algal assemblages are the base of energy flow in these systems and one of the most abundant types of macroalgae on coral reefs, but little is known about their biology and diversity. Through molecular and morphological analyses, we identified the turf-forming species Laurencia cervicornis, and by studying seasonal recruitment and the impact of herbivorous fishes on its abundance, we describe its survival strategy...
July 22, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28733924/cellular-mechanosensitivity-to-substrate-stiffness-decreases-with-increasing-dissimilarity-to-cell-stiffness
#15
Tamer Abdalrahman, Laura Dubuis, Jason Green, Neil Davies, Thomas Franz
Computational modelling has received increasing attention to investigate multi-scale coupled problems in micro-heterogeneous biological structures such as cells. In the current study, we investigated for a single cell the effects of (1) different cell-substrate attachment (2) and different substrate modulus [Formula: see text] on intracellular deformations. A fibroblast was geometrically reconstructed from confocal micrographs. Finite element models of the cell on a planar substrate were developed. Intracellular deformations due to substrate stretch of [Formula: see text], were assessed for: (1) cell-substrate attachment implemented as full basal contact (FC) and 124 focal adhesions (FA), respectively, and [Formula: see text]140 KPa and (2) [Formula: see text], 140, 1000, and 10,000 KPa, respectively, and FA attachment...
July 21, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28733858/snapshots-from-the-cutting-edge-innovations-in-child-and-adolescent-psychiatry-training-to-address-workforce-shortages
#16
EDITORIAL
Anthony P S Guerrero, Laura Weiss Roberts
No abstract text is available yet for this article.
July 21, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28733769/communication-for-coordination-gesture-kinematics-and-conventionality-affect-synchronization-success-in-piano-duos
#17
Laura Bishop, Werner Goebl
Ensemble musicians often exchange visual cues in the form of body gestures (e.g., rhythmic head nods) to help coordinate piece entrances. These cues must communicate beats clearly, especially if the piece requires interperformer synchronization of the first chord. This study aimed to (1) replicate prior findings suggesting that points of peak acceleration in head gestures communicate beat position and (2) identify the kinematic features of head gestures that encourage successful synchronization. It was expected that increased precision of the alignment between leaders' head gestures and first note onsets, increased gesture smoothness, magnitude, and prototypicality, and increased leader ensemble/conducting experience would improve gesture synchronizability...
July 21, 2017: Psychological Research
https://www.readbyqxmd.com/read/28733726/enhancing-capacity-among-faith-based-organizations-to-implement-evidence-based-cancer-control-programs-a-community-engaged-approach
#18
Bryan Leyva, Jennifer D Allen, Hosffman Ospino, Laura S Tom, Rosalyn Negrón, Richard Buesa, Maria Idalí Torres
Evidence-based interventions (EBIs) to promote cancer control among Latinos have proliferated in recent years, though adoption and implementation of these interventions by faith-based organizations (FBOs) is limited. Capacity building may be one strategy to promote implementation. In this qualitative study, 18 community key informants were interviewed to (a) understand existing capacity for health programming among Catholic parishes, (b) characterize parishes' resource gaps and capacity-building needs implementing cancer control EBIs, and (c) elucidate strategies for delivering capacity-building assistance to parishes to facilitate implementation of EBIs...
July 21, 2017: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/28733655/lectin-mediated-reversible-immobilization-of-human-cells-into-a-glycosylated-macroporous-protein-hydrogel-as-a-cell-culture-matrix
#19
Nicholas Bodenberger, Dennis Kubiczek, Laura Trösch, Ali Gawanbacht, Susanne Wilhelm, Denis Tielker, Frank Rosenau
3D cell culture is a helpful approach to study cell-cell interaction in a native-like environment, but is often limited due the challenge of retrieving cells from the material. In this study, we present the use of recombinant lectin B, a sugar-binding protein with four binding cavities, to enable reversible cell integration into a macroporous protein hydrogel matrix. By functionalizing hydrogel precursors with saccharose, lectin B can both bind to sugar moieties on the cellular surface as well as to the modified hydrogel network...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28733445/enhanced-no-dependent-pulmonary-vasodilation-limits-increased-vasoconstrictor-sensitivity-in-neonatal-chronic-hypoxia
#20
Joshua R Sheak, Laura Weise-Cross, Ray J deKay, Benjimen R Walker, Nikki L Jernigan, Thomas C Resta
Augmented vasoconstrictor reactivity is thought to play an important role in the development of chronic hypoxia (CH)-induced neonatal pulmonary hypertension (pHTN). However, whether this response to CH results from pulmonary endothelial dysfunction and reduced NO-mediated vasodilation is not well understood. We hypothesized that neonatal CH enhances basal tone and pulmonary vasoconstrictor sensitivity by limiting NO-dependent pulmonary vasodilation. To test this hypothesis, we assessed effects of the NO synthase (NOS) inhibitor N(w)-nitro-L-arginine (L-NNA) on baseline pulmonary vascular resistance (PVR) and vasoconstrictor sensitivity to the thromboxane mimetic U-46619 in saline-perfused lungs (in situ) from 2-wk-old control and CH (12 day exposure, 0...
July 21, 2017: American Journal of Physiology. Heart and Circulatory Physiology
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