keyword
MENU ▼
Read by QxMD icon Read
search

Laura

keyword
https://www.readbyqxmd.com/read/29053971/a-gut-microbial-mimic-that-hijacks-diabetogenic-autoreactivity-to-suppress-colitis
#1
Roopa Hebbandi Nanjundappa, Francesca Ronchi, Jinguo Wang, Xavier Clemente-Casares, Jun Yamanouchi, Channakeshava Sokke Umeshappa, Yang Yang, Jesús Blanco, Helena Bassolas-Molina, Azucena Salas, Hamza Khan, Robyn M Slattery, Madeleine Wyss, Catherine Mooser, Andrew J Macpherson, Laura K Sycuro, Pau Serra, Derek M McKay, Kathy D McCoy, Pere Santamaria
The gut microbiota contributes to the development of normal immunity but, when dysregulated, can promote autoimmunity through various non-antigen-specific effects on pathogenic and regulatory lymphocytes. Here, we show that an integrase expressed by several species of the gut microbial genus Bacteroides encodes a low-avidity mimotope of the pancreatic β cell autoantigen islet-specific glucose-6-phosphatase-catalytic-subunit-related protein (IGRP206-214). Studies in germ-free mice monocolonized with integrase-competent, integrase-deficient, and integrase-transgenic Bacteroides demonstrate that the microbial epitope promotes the recruitment of diabetogenic CD8+ T cells to the gut...
October 19, 2017: Cell
https://www.readbyqxmd.com/read/29053970/mtorc1-activator-slc38a9-is-required-to-efflux-essential-amino-acids-from-lysosomes-and-use-protein-as-a-nutrient
#2
Gregory A Wyant, Monther Abu-Remaileh, Rachel L Wolfson, Walter W Chen, Elizaveta Freinkman, Laura V Danai, Matthew G Vander Heiden, David M Sabatini
The mTORC1 kinase is a master growth regulator that senses many environmental cues, including amino acids. Activation of mTORC1 by arginine requires SLC38A9, a poorly understood lysosomal membrane protein with homology to amino acid transporters. Here, we validate that SLC38A9 is an arginine sensor for the mTORC1 pathway, and we uncover an unexpectedly central role for SLC38A9 in amino acid homeostasis. SLC38A9 mediates the transport, in an arginine-regulated fashion, of many essential amino acids out of lysosomes, including leucine, which mTORC1 senses through the cytosolic Sestrin proteins...
October 19, 2017: Cell
https://www.readbyqxmd.com/read/29053808/the-impact-of-supplemental-antioxidants-on-visual-function-in-nonadvanced-age-related-macular-degeneration-a-head-to-head-randomized-clinical-trial
#3
Kwadwo Owusu Akuffo, Stephen Beatty, Tunde Peto, Jim Stack, Jim Stringham, David Kelly, Irene Leung, Laura Corcoran, John M Nolan
Purpose: The purpose of this study was to evaluate the impact of supplemental macular carotenoids (including versus not including meso-zeaxanthin) in combination with coantioxidants on visual function in patients with nonadvanced age-related macular degeneration. Methods: In this study, 121 participants were randomly assigned to group 1 (Age-Related Eye Disease Study 2 formulation with a low dose [25 mg] of zinc and an addition of 10 mg meso-zeaxanthin; n = 60) or group 2 (Age-Related Eye Disease Study 2 formulation with a low dose [25 mg] of zinc; n = 61)...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29053742/are-current-chronic-fatigue-syndrome-criteria-diagnosing-different-disease-phenotypes
#4
Laura Maclachlan, Stuart Watson, Peter Gallagher, Andreas Finkelmeyer, Leonard A Jason, Madison Sunnquist, Julia L Newton
IMPORTANCE: Chronic fatigue syndrome (CFS) is characterised by a constellation of symptoms diagnosed with a number of different polythetic criteria. Heterogeneity across these diagnostic criteria is likely to be confounding research into the as-yet-unknown pathophysiology underlying this stigmatised and debilitating condition and may diagnose a disease spectrum with significant implications for clinical management. No studies to date have objectively investigated this possibility using a validated measure of CFS symptoms-the DePaul Symptom Questionnaire (DSQ)...
2017: PloS One
https://www.readbyqxmd.com/read/29053721/xx-disorder-of-sex-development-is-associated-with-an-insertion-on-chromosome-9-and-downregulation-of-rspo1-in-dogs-canis-lupus-familiaris
#5
Vicki N Meyers-Wallen, Adam R Boyko, Charles G Danko, Jennifer K Grenier, Jason G Mezey, Jessica J Hayward, Laura M Shannon, Chuan Gao, Afrah Shafquat, Edward J Rice, Shashikant Pujar, Stefanie Eggers, Thomas Ohnesorg, Andrew H Sinclair
Remarkable progress has been achieved in understanding the mechanisms controlling sex determination, yet the cause for many Disorders of Sex Development (DSD) remains unknown. Of particular interest is a rare XX DSD subtype in which individuals are negative for SRY, the testis determining factor on the Y chromosome, yet develop testes or ovotestes, and both of these phenotypes occur in the same family. This is a naturally occurring disorder in humans (Homo sapiens) and dogs (C. familiaris). Phenotypes in the canine XX DSD model are strikingly similar to those of the human XX DSD subtype...
2017: PloS One
https://www.readbyqxmd.com/read/29053676/laminotomy-for-lumbar-dorsal-root-ganglion-access-and-injection-in-swine
#6
Mark D Unger, Timothy P Maus, Ross C Puffer, Laura K Newman, Bradford L Currier, Andreas S Beutler
Dorsal root ganglia (DRG) are anatomically well defined structures that contain all primary sensory neurons below the head. This fact makes DRG attractive targets for injection of novel therapeutics aimed at treating chronic pain. In small animal models, laminectomy has been used to facilitate DRG injection because it involves surgical removal of the vertebral bone surrounding each DRG. We demonstrate a technique for intraganglionic injection of lumbar DRG in a large animal species, namely, swine. Laminotomy is performed to allow direct access to DRG using standard neurosurgical techniques, instruments, and materials...
October 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29053530/innovative-teaching-for-undergraduate-nursing-students-through-mastery-modeling
#7
Kathleen A Gordon, Kelly E Carmany, Janet R Baker, Laura M Goliat
Mastery modeling was implemented to support the transfer of classroom diabetes content to the clinical area. Interactive teaching methodologies that exemplified mastery modeling included scripted classroom video and vignettes, simulation-based learning experiences, and a worksheet relating to diabetes-specific groups to use in the clinical setting. When mastery modeling teaching methodologies were implemented, transfer of knowledge through clinical reasoning was noted at a higher level for the diabetes-specific groups over the standard groups...
October 20, 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29053509/a-good-sos-nb-is-also-good-for-your-oss
#8
James Andrew Stimpson, Ping Chen, Benjamin Fox, Robin Heij, Jane Hermanowski, Laura Perry
No abstract text is available yet for this article.
November 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29053404/positive-body-image-is-positively-associated-with-hedonic-emotional-and-eudaimonic-psychological-and-social-well-being-in-british-adults
#9
Viren Swami, Laura Weis, David Barron, Adrian Furnham
Studies examining associations between positive body image and well-being have used a limited array of measures of each construct. To rectify this, we asked an online sample of 1148 UK adults to complete a range of measures of positive body image (body appreciation, body image flexibility, body pride, body acceptance from others) and a multi-dimensional measure of well-being (emotional, psychological, and social). Results showed that, once the effects of age and body mass index (BMI) had been accounted for, body appreciation significantly predicted all dimensions of well-being...
October 20, 2017: Journal of Social Psychology
https://www.readbyqxmd.com/read/29053386/promoting-health-from-the-pulpit-a-process-evaluation-of-hiv-sermons-to-reduce-hiv-stigma-and-promote-testing-in-african-american-and-latino-churches
#10
Denise D Payán, Karen R Flórez, Laura M Bogart, David E Kanouse, Michael A Mata, Clyde W Oden, Kathryn P Derose
Embedding health messages into sermons is a potentially valuable strategy to address HIV and other health disparities in churches that predominantly serve racial and ethnic minorities. This study explores implementation of an HIV sermon as part of a multi-component intervention in three churches (Latino Catholic, Latino Pentecostal, and African American Baptist) in high HIV prevalence areas of Los Angeles County, California. Clergy were given an HIV sermon guide that included local public health data, stigma reduction cues, HIV testing messages, and a sample sermon...
October 20, 2017: Health Communication
https://www.readbyqxmd.com/read/29053355/fatal-attraction-intraguild-facilitation-and-suppression-among-predators
#11
Kelly J Sivy, Casey B Pozzanghera, James B Grace, Laura R Prugh
Competition and suppression are recognized as dominant forces that structure predator communities. Facilitation via carrion provisioning, however, is a ubiquitous interaction among predators that could offset the strength of suppression. Understanding the relative importance of these positive and negative interactions is necessary to anticipate community-wide responses to apex predator declines and recoveries worldwide. Using state-sponsored wolf (Canis lupus) control in Alaska as a quasi experiment, we conducted snow track surveys of apex, meso-, and small predators to test for evidence of carnivore cascades (e...
November 2017: American Naturalist
https://www.readbyqxmd.com/read/29053223/the-utility-of-adaptive-elearning-in-cervical-cytopathology-education
#12
T Danielle Samulski, Laura A Taylor, Teresa La, Chelsea R Mehr, Cindy M McGrath, Roseann I Wu
BACKGROUND: Adaptive eLearning allows students to experience a self-paced, individualized curriculum based on prior knowledge and learning ability. METHODS: The authors investigated the effectiveness of adaptive online modules in teaching cervical cytopathology. eLearning modules were created that covered basic concepts in cervical cytopathology, including artifacts and infections, squamous lesions (SL), and glandular lesions (GL). The modules used student responses to individualize the educational curriculum and provide real-time feedback...
October 20, 2017: Cancer
https://www.readbyqxmd.com/read/29053176/the-development-of-regional-dialect-locality-judgments-and-language-attitudes-across-the-life-span
#13
Elizabeth A McCullough, Cynthia G Clopper, Laura Wagner
The development of language attitudes and perception of talker regional background was investigated across the life span (N = 240, age range = 4-75 years). Participants rated 12 talkers on dimensions of geographic locality, status, and solidarity. Children could classify some dialects by locality by age 6-7 years and showed adult-like patterns by age 8 years. Children showed adult-like status ratings for some dialects by age 4-5 years but were not fully adult-like until age 12 years. Solidarity ratings were more variable and did not exhibit a clear developmental trajectory, although some adult-like patterns were in place by age 6-7 years...
October 20, 2017: Child Development
https://www.readbyqxmd.com/read/29052982/designing-a-thermoelectric-copper-rich-sulfide-from-a-natural-mineral-synthetic-germanite-cu22fe8ge4s32
#14
Ventrapati Pavan Kumar, Laura Paradis-Fortin, Pierric Lemoine, Vincent Caignaert, Bernard Raveau, Bernard Malaman, Gérard Le Caër, Stéphane Cordier, Emmanuel Guilmeau
This study shows that the design of copper-rich sulfides by mimicking natural minerals allows a new germanite-type sulfide Cu22Fe8Ge4S32 with promising thermoelectric properties to be synthesized. The Mössbauer spectroscopy and X-ray diffraction analyses provide evidence that the structure of our synthetic compound differs from that of the natural germanite mineral Cu26Fe4Ge4S32 by its much higher Cu(+)/Cu(2+) ratio and different cationic occupancies. The coupled substitution Cu/Fe in the Cu26-xFe4+xGe4S32 series also appears as a promising approach to optimize the thermoelectric properties...
October 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29052767/acute-regulation-of-multidrug-resistance-associated-protein-2-localization-and-activity-by-camp-and-estradiol-17%C3%AE-d-glucuronide-in-rat-intestine-and-caco-2-cells
#15
Guillermo Nicolás Tocchetti, Agostina Arias, Maite Rocío Arana, Juan Pablo Rigalli, Camila Juliana Domínguez, Felipe Zecchinati, María Laura Ruiz, Silvina Stella Maris Villanueva, Aldo Domingo Mottino
Multidrug resistance-associated protein 2 (MRP2) is an ATP-dependent transporter expressed at the brush border membrane of the enterocyte that confers protection against absorption of toxicants from foods or bile. Acute, short-term regulation of intestinal MRP2 activity involving changes in its apical membrane localization was poorly explored. We evaluated the effects of dibutyryl-cAMP (db-cAMP), a permeable analog of cAMP, and estradiol-17β-D-glucuronide (E217G), an endogenous derivative of estradiol, on MRP2 localization and activity using isolated rat intestinal sacs and Caco-2 cells, a model of human intestinal epithelium...
October 20, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29052436/prognostic-impact-of-immunoparesis-at-diagnosis-and-after-treatment-onset-in-patients-with-light-chain-amyloidosis
#16
Luis Gerardo Rodríguez-Lobato, Carlos Fernández de Larrea, Maria Teresa Cibeira, Natalia Tovar, Ignacio Isola, Juan I Aróstegui, Laura Rosiñol, Tania Díaz, Ester Lozano, Jordi Yagüe, Joan Bladé
OBJECTIVES: Immunoparesis (IP) is a risk factor associated with an unfavourable outcome in several plasma cell disorders. It has been suggested that its presence in light-chain (AL) amyloidosis could be associated with worse prognosis. However, the relevance of IP after treatment has not been evaluated to date. The aim of this study was to determine the prognostic impact of IP at diagnosis and one year after treatment onset in patients with AL amyloidosis. METHODS: The clinical records of 69 patients with AL amyloidosis treated at a single institution from January 2006 to January 2016 were included in the study...
October 20, 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/29052310/effect-of-functionalized-phema-micro-and-nano-particles-on-the-viscoelastic-properties-of-fibrin-agarose-biomaterials
#17
Giuseppe Scionti, Laura Rodriguez-Arco, Modesto T Lopez-Lopez, Antonio L Medina-Castillo, Ingrid Garzón, Miguel Alaminos, Manuel Toledano, Raquel Osorio
Two types of PHEMA-based particles, exhibiting either carboxyl or tertiary ammine functional groups, were incorporated to fibrin-agarose hydrogels, and the effect of the addition of these synthetic particles on the viscoelastic and microstructural properties of the biomaterials was evaluated. Experimental results indicated that the incorporation of both types of polymeric particles to fibrin-agarose scaffolds was able to improve the biomechanical properties of the biomaterials under steady state and oscillatory shear stresses, resulting in scaffolds characterized by higher values of the storage, loss and shear moduli...
October 20, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29052265/new-mothers-feelings-of-disappointment-and-failure-after-cesarean-delivery
#18
Kristen H Kjerulff, Laura H Brubaker
BACKGROUND: Childbirth is an important life event and how women feel in retrospect about their first childbirth may have long-term effects on the mother, child, and family. In this study, we investigated the association between mode of delivery at first childbirth and birth experience, using a new scale developed specifically to measure women's affective response. METHODS: This was a prospective cohort study of 3006 women who were interviewed during pregnancy and 1-month postpartum...
October 20, 2017: Birth
https://www.readbyqxmd.com/read/29052146/enzymatic-activity-induction-of-gst-family-isoenzymes-from-pesticide-mixture-used-in-floriculture
#19
Fernando Mejia-Sanchez, Laura Patricia Montenegro-Morales, Julieta Castillo-Cadena
Glutathione S-transferases (GSTs) comprise a number of genes that codify for a group of isoenzymes that participate in phase II xenobiotic detoxification by means of conjugation with glutathione, producing hydrosoluble compounds. It has been demonstrated that some pesticides are substrates for GST isoenzymes. Floriculture is one of the main economic activities in the municipalities of Villa Guerrero and Atlacomulco; pesticides, applied as mixtures, are intensively used in this activity. In this study, total GST enzymatic activity and glutathione S-transferases theta 1 (GSTT1) enzymatic activity were calculated for a group of floriculture workers exposed to pesticides and for an unexposed group...
October 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29052075/dopamine-d1-receptor-activation-maintains-motor-coordination-and-balance-in-rats
#20
Alberto Avila-Luna, Arturo Gálvez-Rosas, Alfredo Durand-Rivera, Laura-Elisa Ramos-Languren, Camilo Ríos, José-Antonio Arias-Montaño, Antonio Bueno-Nava
Dopamine (DA) modulates motor coordination, and its depletion, as in Parkinson's disease, produces motor impairment. The basal ganglia, cerebellum and cerebral cortex are interconnected, have functional roles in motor coordination, and possess dopamine D1 receptors (D1Rs), which are expressed at a particularly high density in the basal ganglia. In this study, we examined whether the activation of D1Rs modulates motor coordination and balance in the rat using a beam-walking test that has previously been used to detect motor coordination deficits...
October 19, 2017: Metabolic Brain Disease
keyword
keyword
9093
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"