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JOURNAL ARTICLE
#2
JOURNAL ARTICLE
Miguel Mansilla-Polo, Laura Puebla-Tornero, Lía Bejarano-Antonio, Ángel Santos-Briz
No abstract text is available yet for this article.
March 8, 2024: American Journal of Dermatopathology
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JOURNAL ARTICLE
Mallory M Przybylski, Daniel T Hall, Laura H Ikuma
The primary objectives of any high-volume surgery department should be patient safety, block time utilization and operating room efficiency. Reducing preparation time in the OR prior to actual surgery can improve operating room efficiency and utilization, but only if patient safety can be maintained. With this goal, this study evaluated a novel skin preparation technique using a device named ULTRAPREP™, a sterile, medical-grade plastic bag that is applied to the upper or lower extremity in the pre-operative holding area which allows for skin disinfection outside the OR (referred to as "disinfection bag")...
April 18, 2024: Surgical Technology International
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JOURNAL ARTICLE
Laura Arnold, Simon Bimczok, Timo Clemens, Helmut Brand, Dagmar Starke
The COVID-19 pandemic has highlighted the importance of local evidence ecosystems in which academia and practice in the Public Health Service (PHS) are interconnected. However, appropriate organizational structures and well-trained staff are lacking and evidence use in local public health decision-making has to be integrated into training programs in Germany. To address this issue, we developed a framework incorporating a toolbox to conceptualize training programs designed to qualify public health professionals for working at the interface between academia and practice...
2024: PloS One
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JOURNAL ARTICLE
Laura van Ginkel, Lotte Dupuis, Luc Verhamme, Erik Hermans, Thomas J J Maal, Vincent Stirler
The conventional treatment for distal radius fractures typically involves immobilization of the injured extremity using a conventional forearm cast. These casts do cause all sorts of discomfort during wear and impose life-style restrictions on the wearer. Personalized 3D printed splints, designed using three-dimensional (3D) imaging systems, might overcome these problems. To obtain a patient specific splint, commercially available 3D camera systems are utilized to capture patient extremities, generating 3D models for splint design...
April 2024: PLOS Digit Health
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JOURNAL ARTICLE
Anastasia Knyazeva, Shuang Li, Dale P Corkery, Kasturika Shankar, Laura K Herzog, Xuepei Zhang, Birendra Singh, Georg Niggemeyer, David Grill, Jonathan D Gilthorpe, Massimiliano Gaetani, Lars-Anders Carlson, Herbert Waldmann, Yao-Wen Wu
The endosomal sorting complex required for transport (ESCRT) machinery constitutes multisubunit protein complexes that play an essential role in membrane remodeling and trafficking. ESCRTs regulate a wide array of cellular processes, including cytokinetic abscission, cargo sorting into multivesicular bodies (MVBs), membrane repair, and autophagy. Given the versatile functionality of ESCRTs, and the intricate organizational structure of the ESCRT machinery, the targeted modulation of distinct ESCRT complexes is considerably challenging...
April 23, 2024: Proceedings of the National Academy of Sciences of the United States of America
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JOURNAL ARTICLE
Laura J McGowan, Deepti A John, Ryan P W Kenny, Emma C Joyes, Emma A Adams, Hosein Shabaninejad, Catherine Richmond, Fiona R Beyer, David Landes, Richard G Watt, Falko F Sniehotta, Martha Paisi, Claire Bambra, Dawn Craig, Eileen Kaner, Sheena E Ramsay
BACKGROUND: People experiencing homelessness co-occurring with substance use or offending ('severe and multiple disadvantage' SMD) often have high levels of poor oral health and related health behaviours (particularly, substance use, smoking, poor diet). This systematic review aimed to assess the effectiveness and cost-effectiveness of interventions in adults experiencing SMD to improve oral health and related health behaviours. METHODS AND FINDINGS: From inception to February 2023, five bibliographic databases (MEDLINE, EMBASE, PsycINFO, CINAHL, and Scopus) and grey literature were searched...
2024: PloS One
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JOURNAL ARTICLE
Laura D Zambrano, Margaret M Newhams, Regina M Simeone, Amanda B Payne, Michael Wu, Amber O Orzel-Lockwood, Natasha B Halasa, Jemima M Calixte, Pia S Pannaraj, Kanokporn Mongkolrattanothai, Julie A Boom, Leila C Sahni, Satoshi Kamidani, Kathleen Chiotos, Melissa A Cameron, Aline B Maddux, Katherine Irby, Jennifer E Schuster, Elizabeth H Mack, Austin Biggs, Bria M Coates, Kelly N Michelson, Katherine E Bline, Ryan A Nofziger, Hillary Crandall, Charlotte V Hobbs, Shira J Gertz, Sabrina M Heidemann, Tamara T Bradford, Tracie C Walker, Stephanie P Schwartz, Mary Allen Staat, Samina S Bhumbra, Janet R Hume, Michele Kong, Melissa S Stockwell, Thomas J Connors, Melissa L Cullimore, Heidi R Flori, Emily R Levy, Natalie Z Cvijanovich, Matt S Zinter, Mia Maamari, Cindy Bowens, Danielle M Zerr, Judith A Guzman-Cottrill, Ivan Gonzalez, Angela P Campbell, Adrienne G Randolph
Pediatric COVID-19 vaccination is effective in preventing COVID-19-related hospitalization, but duration of protection of the original monovalent vaccine during SARS-CoV-2 Omicron predominance merits evaluation, particularly given low coverage with updated COVID-19 vaccines. During December 19, 2021-October 29, 2023, the Overcoming COVID-19 Network evaluated vaccine effectiveness (VE) of ≥2 original monovalent COVID-19 mRNA vaccine doses against COVID-19-related hospitalization and critical illness among U...
April 18, 2024: MMWR. Morbidity and Mortality Weekly Report
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JOURNAL ARTICLE
Colby Behrens, Meghan F Maciejewski, Eric Arredondo, Anne C Dalziel, Laura K Weir, Alison M Bell
AbstractThe mechanisms underlying the divergence of reproductive strategies between closely related species are still poorly understood. Additionally, it is unclear which selective factors drive the evolution of reproductive behavioral variation and how these traits coevolve, particularly during early divergence. To address these questions, we quantified behavioral differences in a recently diverged pair of Nova Scotian three-spined stickleback ( Gasterosteus aculeatus ) populations, which vary in parental care, with one population displaying paternal care and the other lacking this...
May 2024: American Naturalist
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JOURNAL ARTICLE
Lei Wang, Andrea Daru, Bhavnesh Jangid, Jie-Hao Chen, Ningxin Jiang, Shrayesh N Patel, Laura Gagliardi, John S Anderson
Two-dimensional conductive metal-organic frameworks have emerged as promising electronic materials for applications in (opto)electronic, thermoelectric, magnetic, electrocatalytic, and energy storage devices. Many bottom-up or postsynthetic protocols have been developed to isolate these materials or further modulate their electronic properties. However, some methodologies commonly used in classic semiconductors, notably, aliovalent substitution, are conspicuously absent. Here, we demonstrate how aliovalent Fe(III) to Ni(II) substitution enables the isolation of a Ni bis(dithiolene) material from a previously reported Fe analogue...
April 18, 2024: Journal of the American Chemical Society
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JOURNAL ARTICLE
Camilo Scherkl, Andreas D Meid, Sven E Cuntz, Laura Classen, Johanna Weiss, David Czock, Walter E Haefeli
Individual sirolimus whole blood concentrations are highly variable, critically influenced by the concomitant use of cytochrome P450 (CYP) 3A inducers or inhibitors, and also modulated by food. Therapeutic drug monitoring is therefore recommended, especially at treatment start or in circumstances that can influence sirolimus exposure. In this case report, we highlight the challenge of achieving therapeutic sirolimus concentrations and present pragmatic solutions with regimen adaptions, pharmacokinetic enhancement (use of a drug-drug interaction), concentration monitoring, and subsequent modeling of population pharmacokinetics to support treatment decisions...
June 2024: Pharmacology Research & Perspectives
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JOURNAL ARTICLE
Jessica M Powers, Sarah F Maloney, Eva Sharma, Laura R Stroud
OBJECTIVE: Co-use of tobacco and cannabis may be prevalent in pregnancy, potentially leading to additional adverse health outcomes. Utilizing a national sample of women followed prospectively before, during, and after pregnancy, this study tested whether prepregnancy co-use of tobacco and cannabis (vs. tobacco-only use and cannabis-only use) was associated with greater likelihood of continuing to use tobacco and/or cannabis during pregnancy and postpartum. METHOD: Data were drawn from Waves 1-5 (2013-2019) of the Population Assessment of Tobacco and Health (PATH) Study...
April 18, 2024: Psychology of Addictive Behaviors
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JOURNAL ARTICLE
Laura S Brown
In this invited commentary, I address what I see as the major contributions Rubenstein et al. (2024) have made to challenging the hegemony of exposure therapies for trauma-exposed persons. These include a thorough review of the history of the rise of exposure therapies, the identification of posttrauma responses as forms of anxiety disorders, and an extensive discussion of the neurobiology of the trauma response. Additionally, Rubenstein et al. expose the very high dropout rates in studies of exposure therapies and ways in which many traumatized people have not found them helpful...
April 2024: American Psychologist
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JOURNAL ARTICLE
Marika Pane, Giulia Stanca, Chiara Ticci, Costanza Cutrona, Roberto De Sanctis, Matteo Pirinu, Giorgia Coratti, Concetta Palermo, Beatrice Berti, Daniela Leone, Michele Sacchini, Margherita Cerboneschi, Lavinia Fanelli, Giulia Norcia, Nicola Forcina, Anna Capasso, Gianpaolo Cicala, Laura Antonaci, Martina Ricci, Maria Carmela Pera, Chiara Bravetti, Maria Alice Donati, Elena Procopio, Emanuela Abiusi, Alessandro Vaisfeld, Roberta Onesimo, Francesco Danilo Tiziano, Eugenio Mercuri
Neonatal screening for SMA has allowed the identification of infants who may present with early clinical signs. Our aim was to establish whether the presence and the severity of early clinical signs have an effect on the development of motor milestones. Infants identified through newborn screening were prospectively assessed using a structured neonatal neurological examination and an additional module developed for the assessment of floppy infants. As part of the follow-up, all infants were assessed using the HINE-2 to establish developmental milestones...
April 18, 2024: European Journal of Pediatrics
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JOURNAL ARTICLE
Pascual Sánchez-Juan, Elizabeth Valeriano-Lorenzo, Alicia Ruiz-González, Ana Belén Pastor, Hector Rodrigo Lara, Francisco López-González, María Ascensión Zea-Sevilla, Meritxell Valentí, Belen Frades, Paloma Ruiz, Laura Saiz, Iván Burgueño-García, Miguel Calero, Teodoro Del Ser, Alberto Rábano
Glial fibrillary acidic protein (GFAP), a proxy of astrocyte reactivity, has been proposed as biomarker of Alzheimer's disease. However, there is limited information about the correlation between blood biomarkers and post-mortem neuropathology. In a single-centre prospective clinicopathological cohort of 139 dementia patients, for which the time-frame between GFAP level determination and neuropathological assessment was exceptionally short (on average 139 days), we analysed this biomarker, measured at three time points, in relation to proxies of disease progression such as cognitive decline and brain weight...
April 18, 2024: Brain
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REVIEW
Lisa S den Hollander, Adriaan P IJzerman, Laura H Heitman
Chemokine receptors are relevant targets for a multitude of immunological diseases, but drug attrition for these receptors is remarkably high. While many drug discovery programs have been pursued, most prospective drugs failed in the follow-up studies due to clinical inefficacy, and hence there is a clear need for alternative approaches. Allosteric modulators of receptor function represent an excellent opportunity for novel drugs, as they modulate receptor activation in a controlled manner and display increased selectivity, and their pharmacological profile can be insurmountable...
April 18, 2024: Medicinal Research Reviews
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JOURNAL ARTICLE
John P F A Heesakkers, Philip Toozs-Hobson, Suzette E Sutherland, Alex Digesu, Cindy L Amundsen, Rebecca J McCrery, Stefan De Wachter, Emily R Kean, Frank Martens, Kevin Benson, Kimberly L Ferrante, Kevin J Cline, Osvaldo F Padron, Laura Giusto, Felicia L Lane, Roger R Dmochowski
BACKGROUND: Overactive bladder (OAB) affects one in six adults in Europe and the United States and impairs the quality of life of millions of individuals worldwide. When conservative management fails, third-line treatments including tibial neuromodulation (TNM) is often pursued. TNM has traditionally been accomplished percutaneously in clinic. OBJECTIVE: A minimally invasive implantable device activated by a battery-operated external wearable unit has been developed for the treatment of urgency urinary incontinence (UUI), mitigating the burden of frequent clinic visits and more invasive therapies that are currently commercially available...
April 18, 2024: Neurourology and Urodynamics
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JOURNAL ARTICLE
Danielle Sansonetti, Jennifer Fleming, Freyr Patterson, Laura De Lacy, Natasha A Lannin
BACKGROUND: Self-awareness impairment is common following acquired brain injury and can impact rehabilitation outcomes. Knowledge of factors associated with impaired self-awareness may assist with rehabilitation planning. OBJECTIVES: To identify factors associated with self-awareness and determine predictors of self-awareness impairment for adults with traumatic brain injury (TBI) and stroke. DESIGN AND METHODS: A retrospective cohort study of rehabilitation inpatients was conducted by medical record audit...
April 18, 2024: Brain Injury
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JOURNAL ARTICLE
Yvette C Tanhehco, Mohamed Alsammak, Vishesh Chhibber, Nnaemeka Ibeh, Yanhua Li, Laura D Stephens, Daniel K Noland, Ding Wen Wu, Nicole D Zantek, Phillip J DeChristopher, Marisa Claudia Saint Martin, Wen Lu, Gay Wehrli
BACKGROUND: The COVID-19 pandemic affected healthcare delivery across all specialties including apheresis. To describe the changes in apheresis service practices that occurred during the pandemic, the American Society for Apheresis (ASFA) Apheresis Medicine Attending Physician Subcommittee conducted a survey study. STUDY DESIGN AND METHODS: A 32-question survey was designed and distributed to 400 ASFA physician members on September 7, 2022. Attending physicians responded to questions about whether and how apheresis service practices changed during the COVID-19 pandemic compared with the time period prior to the pandemic in terms of: (1) procedure types and volumes, (2) patient consultation workflow, and (3) the use of telemedicine...
June 2024: Journal of Clinical Apheresis
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JOURNAL ARTICLE
Daniela Silva Canella, Maria Laura da Costa Louzada, Natália Oliveira, Ana Beatriz Coelho de Azevedo, Renata Bertazzi Levy
The objective of this study was to describe the evolution of household purchase of added sugars and their main food sources in Brazil. Nationally representative data from the Household Budget Surveys from 2002-03, 2008-09 and 2017-18 were used. Energy and added sugar quantities were estimated by means of per capita food quantities. The following items were considered as food sources: 1. table sugar: refined sugar and other caloric sweeteners; and 2) processed and ultra-processed foods with added sugar: soft drinks; other drinks; sweets, candies, and chocolates; cookies; cakes and pies; and other foods...
April 18, 2024: British Journal of Nutrition
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