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https://www.readbyqxmd.com/read/27933548/metabolic-characterization-of-acutely-isolated-hippocampal-and-cerebral-cortical-slices-using-u-13-c-glucose-and-1-2-13-c-acetate-as-substrates
#1
Laura F McNair, Rasmus Kornfelt, Anne B Walls, Jens V Andersen, Blanca I Aldana, Jakob D Nissen, Arne Schousboe, Helle S Waagepetersen
Brain slice preparations from rats, mice and guinea pigs have served as important tools for studies of neurotransmission and metabolism. While hippocampal slices routinely have been used for electrophysiology studies, metabolic processes have mostly been studied in cerebral cortical slices. Few comparative characterization studies exist for acute hippocampal and cerebral cortical slices, hence, the aim of the current study was to characterize and compare glucose and acetate metabolism in these slice preparations in a newly established incubation design...
December 8, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27933531/using-baseline-transcriptional-connectomes-in-rat-to-identify-genetic-pathways-associated-with-predisposition-to-complex-traits
#2
Laura Saba, Paula Hoffman, Boris Tabakoff
Although rat is a critical model organism in preclinical medications development, its use in systems genetics studies remains sparse. The PhenoGen database and website contain detailed information on the qualitative and quantitative aspects of the rat brain, liver, heart, and brown adipose transcriptome. This database has been generated using the HXB/BXH recombinant inbred panel and is being expanded to a hybrid rat diversity panel that includes many common inbred strains as well. By using such a panel, the PhenoGen project has created a renewable and cumulative resource for the rat genomics community...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27933499/assessment-of-molecularly-imprinted-polymers-mips-in-the-preconcentration-of-disperse-red-73-dye-prior-to-photoelectrocatalytic-treatment
#3
Jefferson Honorio Franco, Alejandra Ben Aissa, Guilherme Garcia Bessegato, Laura Martinez Fajardo, Maria Valnice Boldrin Zanoni, María Isabel Pividori, Maria Del Pilar Taboada Sotomayor
Magnetic molecularly imprinted polymers (MMIPs) have become a research hotspot due to their two important characteristics: target recognition and magnetic separation. This paper presents the preparation, characterization, and optimization of an MMIP for the preconcentration of disperse red 73 dye (DR73) and its subsequent efficient degradation by photoelectrocatalytic treatment. The MMIPs were characterized by scanning electron microscopy (SEM), which revealed homogeneous distribution of the particles. Excellent encapsulation of magnetite was confirmed by transmission electron microscopy (TEM)...
December 8, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27933315/immunogenicity-of-self-tumor-associated-proteins-is-enhanced-through-protein-truncation
#4
Tim Kottke, Kevin G Shim, Vanesa Alonso-Camino, Shane Zaidi, Rosa Maria Diaz, Jose Pulido, Jill Thompson, Karishma R Rajani, Laura Evgin, Elizabeth Ilett, Hardev Pandha, Kevin Harrington, Peter Selby, Alan Melcher, Richard Vile
We showed previously that therapy with Vesicular Stomatitis Virus (VSV) expressing tumor-associated proteins eradicates established tumors. We show here that when cellular cDNA were cloned into VSV which retained their own poly-A signal, viral species emerged in culture which had deleted the cellular poly-A signal and also contained a truncated form of the protein coding sequence. Typically, the truncation occurred such that a Tyrosine-encoding codon was converted into a STOP codon. We believe that the truncation of tumor-associated proteins expressed from VSV in this way occurred to preserve the ability of the virus to replicate efficiently...
2016: Molecular Therapy Oncolytics
https://www.readbyqxmd.com/read/27932945/monoaminergic-and-histaminergic-strategies-and-treatments-in-brain-diseases
#5
REVIEW
Giuseppe Di Giovanni, Dubravka Svob Strac, Montse Sole, Mercedes Unzeta, Keith F Tipton, Dorotea Mück-Šeler, Irene Bolea, Laura Della Corte, Matea Nikolac Perkovic, Nela Pivac, Ilse J Smolders, Anna Stasiak, Wieslawa A Fogel, Philippe De Deurwaerdère
The monoaminergic systems are the target of several drugs for the treatment of mood, motor and cognitive disorders as well as neurological conditions. In most cases, advances have occurred through serendipity, except for Parkinson's disease where the pathophysiology led almost immediately to the introduction of dopamine restoring agents. Extensive neuropharmacological studies first showed that the primary target of antipsychotics, antidepressants, and anxiolytic drugs were specific components of the monoaminergic systems...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27932717/-would-you-eat-an-alien
#6
(no author information available yet)
A novel way of exploring comparative cognition, animal welfare ethics and human-animal relations formed the basis of this year's Wooldridge Memorial Lecture, held during the BVA Congress at the London Vet Show last month. Christine Nicol, of the University of Bristol, shared her experiences of making the BBC Radio 4 series 'Would you eat an alien?' and gave an insight into the ethical dilemmas that formed the basis of the programme. Laura Honey reports.
December 10, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27932649/detection-and-genomic-characterization-of-enterovirus-d68-in-respiratory-samples-isolated-in-the-united-states-in-2016
#7
Terry Fei Fan Ng, Anna Montmayeur, Christina Castro, Marshall Cone, Joey Stringer, Daryl M Lamson, Shannon L Rogers, Shur-Wern Wang Chern, Laura Magaña, Rachel Marine, Heather Rubino, Daniel Serinaldi, Kirsten St George, W Allan Nix
The genomic sequences of three 2016 enterovirus D68 (EV-D68) strains were obtained from respiratory samples of patients from Florida, Texas, and New York. These EV-D68 sequences share highest nucleotide identities with strains that circulated in North America, Europe, and Asia in 2014-2015.
December 8, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27932646/genome-sequence-of-airborne-acinetobacter-sp-strain-5-2ac02-in-the-hospital-environment-close-to-the-species-of-acinetobacter-towneri
#8
Beathriz G V Barbosa, Laura Fernandez-García, Eva Gato, Maria López, Lucia Blasco, Robson Souza Leão, Rodolpho M Albano, Begoña Fernández, Felipe-Fernández Cuenca, Álvaro Pascual, German Bou, Elizabeth A Marques, María Tomás
Acinetobacter spp. are found in 53% of air colonization samples from the hospital environment. In this work, we sequenced all the genome of airborne Acinetobacter sp. strain 5-2Ac02. We found important features at the genomic level in regards to the rhizome. By phylogenetic analysis, A. towneri was the species most closely related to Acinetobacter sp. 5-2Ac02.
December 8, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27932638/draft-genome-sequences-of-three-hypervirulent-carbapenem-resistant-klebsiella-pneumoniae-isolates-from-bacteremia
#9
Chaitra Shankar, Laura E B Nabarro, Naveen Kumar Devanga Ragupathi, Dhiviya Prabaa Muthuirulandi Sethuvel, Jones Lionel Kumar Daniel, George Priya Doss C, Balaji Veeraraghavan
Hypervirulent Klebsiella pneumoniae strains have been increasingly reported worldwide, and there is emergence of carbapenem resistance among them. Here, we report the genome sequences of three carbapenem-resistant hypervirulent K. pneumoniae isolates isolated from bacteremic patients at a tertiary-care center in South India.
December 8, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27932594/the-interaction-between-genetic-ancestry-and-breast-cancer-risk-factors-among-hispanic-women-the-breast-cancer-health-disparities-study
#10
Lisa M Hines, Rebecca L Sedjo, Tim Byers, Esther M John, Laura Fejerman, Mariana C Stern, Kathy Baumgartner, Anna R Giuliano, Gabriela Torres-Mejia, Wolff Roger, Kylie Harrall, Martha L Slattery
BACKGROUND: Hispanic women have lower breast cancer incidence rates than non-Hispanic white (NHW) women. To what extent genetic versus non-genetic factors account for this difference is unknown. METHODS: Using logistic regression, we evaluated the interactive influences of established risk factors and ethnicity (self-identified and identified by ancestral informative markers) on breast cancer risk among 2326 Hispanic and 1854 NHW postmenopausal women from the US and Mexico in the Breast Cancer Health Disparities Study...
December 8, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27932546/what-can-a-participatory-approach-to-evaluation-contribute-to-the-field-of-integrated-care
#11
Laura Eyre, Michael Farrelly, Martin Marshall
Better integration of care within the health sector and between health and social care is seen in many countries as an essential way of addressing the enduring problems of dwindling resources, changing demographics and unacceptable variation in quality of care. Current research evidence about the effectiveness of integration efforts supports neither the enthusiasm of those promoting and designing integrated care programmes nor the growing efforts of practitioners attempting to integrate care on the ground. In this paper we present a methodological approach, based on the principles of participatory research, that attempts to address this challenge...
December 8, 2016: BMJ Quality & Safety
https://www.readbyqxmd.com/read/27932067/nivolumab-plus-ipilimumab-as-first-line-treatment-for-advanced-non-small-cell-lung-cancer-checkmate-012-results-of-an-open-label-phase-1-multicohort-study
#12
Matthew D Hellmann, Naiyer A Rizvi, Jonathan W Goldman, Scott N Gettinger, Hossein Borghaei, Julie R Brahmer, Neal E Ready, David E Gerber, Laura Q Chow, Rosalyn A Juergens, Frances A Shepherd, Scott A Laurie, William J Geese, Shruti Agrawal, Tina C Young, Xuemei Li, Scott J Antonia
BACKGROUND: Nivolumab has shown improved survival in the treatment of advanced non-small-cell lung cancer (NSCLC) previously treated with chemotherapy. We assessed the safety and activity of combination nivolumab plus ipilimumab as first-line therapy for NSCLC. METHODS: The open-label, phase 1, multicohort study (CheckMate 012) cohorts reported here were enrolled at eight US academic centres. Eligible patients were aged 18 years or older with histologically or cytologically confirmed recurrent stage IIIb or stage IV, chemotherapy-naive NSCLC...
December 2, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27931939/ex-situ-biogas-upgrading-and-enhancement-in-different-reactor-systems
#13
Panagiotis G Kougias, Laura Treu, Daniela Peñailillo Benavente, Kanokwan Boe, Stefano Campanaro, Irini Angelidaki
Biogas upgrading is envisioned as a key process for clean energy production. The current study evaluates the efficiency of different reactor configurations for ex-situ biogas upgrading and enhancement, in which externally provided hydrogen and carbon dioxide were biologically converted to methane by the action of hydrogenotrophic methanogens. The methane content in the output gas of the most efficient configuration was >98%, allowing its exploitation as substitute to natural gas. Additionally, use of digestate from biogas plants as a cost efficient method to provide all the necessary nutrients for microbial growth was successful...
December 2, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27931841/new-molecular-therapies-in-patients-with-advanced-hepatocellular-cancer-in-second-line-of-treatment-is-a-real-defeat-results-from-a-literature-based-meta-analysis-of-randomized-trials
#14
REVIEW
Giandomenico Roviello, Laura Zanotti, Maria Rosa Cappelletti, Angela Gobbi, Giulia Borsella, Chiara Pacifico, Andrea Giovanni Multari, Daniele Generali
Several new biological agents have been investigated as second line of treatment in advanced Hepatocellular Cancer (HCC). We performed a meta-analysis to assess the effect of targeted therapies in advanced HCC patients beyond the first line of treatment. A literature-based metaanalysis of randomized controlled trials was undertaken. The primary outcome was the overall survival. The secondary endpoints were the progression-free survival (PFS), the response rate (RR) and disease control rate (DCR) and the safety...
December 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27931798/differential-expression-of-low-density-lipoprotein-receptor-related-protein-1-lrp-1-and-matrix-metalloproteinase-9-mmp-9-in-prostate-gland-from-normal-to-malignant-lesions
#15
Mónica B Gilardoni, María M Remedi, Mabel Oviedo, Tristán Dellavedova, Juan P Sarría, Laura Racca, Mariana Dominguez, Claudia G Pellizas, Ana C Donadio
BACKGROUND: Metalloproteinases (MMPs) are relevant modulators of inflammation, tumor microenvironment, cancer invasion and metastasis. They can be regulated by the Low density lipoprotein Receptor-related Protein 1 (LRP-1), a receptor reported to mediate the clearance of lipoproteins, extracellular matrix (ECM) macromolecules and proteinases. The aim of this study was to evaluate the expression of LRP-1, MMP-2 and MMP-9 across various grades of prostatic diseases as benign prostatic hyperplasia (BPH), BPH plus prostatitis (BPH+P), high grade prostatic intraepithelial neoplasia (HGPIN) and prostate cancer (PCa)...
November 24, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27931795/ikk%C3%AE-inibition-by-a-glucosamine-derivative-enhances-maspin-expression-in-osteosarcoma-cell-line
#16
Martina Leopizzi, Rossana Cocchiola, Edoardo Milanetti, Domenico Raimondo, Laura Politi, Cesare Giordano, Roberto Scandurra, Anna Scotto d'Abusco
Chronic inflammation has been associated to cancer development by the alteration of several inflammatory pathways, such as Nuclear Factor-κB pathway. In particular, IκB kinase α (IKKα), one of two catalytic subunit of IKK complex, has been described to be associated to cancer progression and metastasis in a number of cancers. The molecular mechanism by which IKKα affects cancer progression is not yet completely clarified, anyway an association between IKKα and the expression of Maspin (Mammary Serine Protease Inhibitor or SerpinB5), a tumor suppressor protein, has been described...
December 5, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27931645/haemodynamic-coherence%C3%A2-%C3%A2-the-relevance-of-fluid-therapy
#17
REVIEW
Philip Arnemann, Laura Seidel, Christian Ertmer
The ultimate goal of fluid therapy is to improve the oxygenation of cells by improving the cardiac output, thus improving microcirculation by optimizing macrocirculation. This haemodynamic coherence is often altered in patients with haemorrhagic shock and sepsis. The loss of haemodynamic coherence is associated with adverse outcomes. It may be influenced by the mechanisms of the underlying disease and properties of different fluids used for resuscitation in these critically ill patients. Monitoring microcirculation and haemodynamic coherence may be an additional tool to predict the response to fluid administration...
December 2016: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/27931115/secretory-structures-and-essential-oil-composition-in-stachys-officinalis-l-trevisan-subsp-officinalis-lamiaceae-from-italy
#18
Claudia Giuliani, Roberto Maria Pellegrino, Roberta Selvaggi, Corrado Tani, Bruno Tirillini, Laura Maleci Bini
The secretory structures and the volatile fraction of Stachys officinalis (L.) Trevisan subsp. officinalis (Lamiaceae) from Italy were studied for the first time. Peltate and small capitate trichomes were observed on the whole plant (leaves and inflorescences). In the peltate trichomes, an unusual polyphenols content was evidenced by the histochemical methods. The volatile fraction was obtained by a solvent extract from the distillation water of leaves and inflorescences and analysed by GC-MS. Forty-four constituents for leaves, representing 94...
December 8, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27930922/molecular-dynamics-simulations-of-cesium-adsorption-on-illite-nanoparticles
#19
Laura N Lammers, Ian C Bourg, Masahiko Okumura, Kedarnath Kolluri, Garrison Sposito, Masahiko Machida
The charged surfaces of micaceous minerals, especially illite, regulate the mobility of the major radioisotopes of Cs ((134)Cs, (135)Cs, (137)Cs) in the geosphere. Despite the long history of Cs adsorption studies, the nature of the illite surface sites remains incompletely understood. To address this problem, we present atomistic simulations of Cs competition with Na for three candidate illite adsorption sites - edge, basal plane, and interlayer. Our simulation results are broadly consistent with affinities and selectivities that have been inferred from surface complexation models...
November 29, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27930910/the-neurobiology-of-zika-virus
#20
REVIEW
Hongda Li, Laura Saucedo-Cuevas, Sujan Shresta, Joseph G Gleeson
Zika virus (ZIVK) represents a new threat to global health, with particular relevance to neuroscientists, due to associated newborn and adult neurological disease. Consequences of vertical infection include microcephaly with brain and eye anomalies, and consequences of adult infection include Guillain-Barré syndrome (GBS) and meningoencephalitis. Recent data suggest specific vulnerability of neural progenitors to infection, leading to cell death and brain calcification, reminiscent of other viral syndromes...
December 7, 2016: Neuron
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