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https://www.readbyqxmd.com/read/28644823/eeg-characteristics-in-cooled-and-rewarmed-periods-in-post-cardiac-arrest-therapeutic-hypothermia-patients
#1
K Kim, Kimberly L Pargeon, Amy S Labar, Oren Friedman, Padmaja N Kandula, Douglas R Labar
PURPOSE: Continuous video EEG is a tool to assess brain function in injuries, including cardiac arrest (CA). In post-CA therapeutic hypothermia (TH) studies, some EEG features are linked to poor prognosis, but the evolvement of EEG characteristics during two temperature phases and its significance is unclear. We systematically analyzed EEG characteristics in cooled and rewarmed phases of post-CA therapeutic hypothermia patients and investigated their correlation to patient outcome. METHODS: This is a retrospective study of EEG analyses, from a single academic center, of 20 patients who underwent CA and therapeutic hypothermia...
July 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28640776/early-fever-after-trauma-does-it-matter
#2
Holly E Hinson, Susan Rowell, Cynthia Morris, Amber L Lin, Martin A Schreiber
BACKGROUND: Fever is strongly associated with poor outcome after traumatic brain injury (TBI). We hypothesized that early fever is a direct result of brain injury and thus would be more common in TBI than in patients without brain injury, and associated with inflammation. METHODS: We prospectively enrolled patients with major trauma with and without TBI from a busy level I trauma center ICU. Patients were assigned to one of four groups based on their presenting Head Abbreviated Injury Severity Scale scores (HAIS): Polytrauma: Head AIS score >2, one other region>2, Isolated Head: Head AIS score>2, all other regions <3, Isolated Body: One region >2, excluding Head/Face, Minor Injury: No region with AIS>2...
June 20, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28634443/the-narrow-abdomen-ion-channel-complex-is-highly-stable-and-persists-from-development-into-adult-stages-to-promote-behavioral-rhythmicity
#3
Devon L Moose, Stephanie J Haase, Benjamin T Aldrich, Bridget C Lear
The sodium leak channel NARROW ABDOMEN (NA)/ NALCN is an important component of circadian pacemaker neuronal output. In Drosophila, rhythmic expression of the NA channel regulator Nlf-1 in a subset of adult pacemaker neurons has been proposed to contribute to circadian regulation of channel localization or activity. Here we have restricted expression of Drosophila NA channel subunits or the Nlf-1 regulator to either development or adulthood using the temperature-inducible tubulin-GAL80(ts) system. Surprisingly, we find that developmental expression of endogenous channel subunits and Nlf-1 is sufficient to promote robust rhythmic behavior in adults...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28631089/targeted-temperature-management-in-the-icu-guidelines-from-a-french-expert-panel
#4
REVIEW
Alain Cariou, Jean-François Payen, Karim Asehnoune, Gerard Audibert, Astrid Botte, Olivier Brissaud, Guillaume Debaty, Sandrine Deltour, Nicolas Deye, Nicolas Engrand, Gilles Francony, Stéphane Legriel, Bruno Levy, Philippe Meyer, Jean-Christophe Orban, Sylvain Renolleau, Bernard Vigue, Laure De Saint Blanquat, Cyrille Mathien, Lionel Velly
Over the recent period, the use of induced hypothermia has gained an increasing interest for critically ill patients, in particular in brain-injured patients. The term "targeted temperature management" (TTM) has now emerged as the most appropriate when referring to interventions used to reach and maintain a specific level temperature for each individual. TTM may be used to prevent fever, to maintain normothermia, or to lower core temperature. This treatment is widely used in intensive care units, mostly as a primary neuroprotective method...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28630878/prediction-of-brain-tissue-temperature-using-near-infrared-spectroscopy
#5
Lisa Holper, Subhabrata Mitra, Gemma Bale, Nicola Robertson, Ilias Tachtsidis
Broadband near-infrared spectroscopy (NIRS) can provide an endogenous indicator of tissue temperature based on the temperature dependence of the water absorption spectrum. We describe a first evaluation of the calibration and prediction of brain tissue temperature obtained during hypothermia in newborn piglets (animal dataset) and rewarming in newborn infants (human dataset) based on measured body (rectal) temperature. The calibration using partial least squares regression proved to be a reliable method to predict brain tissue temperature with respect to core body temperature in the wavelength interval of 720 to 880 nm with a strong mean predictive power of [Formula: see text] (animal dataset) and [Formula: see text] (human dataset)...
April 2017: Neurophotonics
https://www.readbyqxmd.com/read/28629741/establishment-of-an-ideal-time-window-model-in-hypothermic-targeted-temperature-management-after-traumatic-brain-injury-in-rats
#6
Wan-Yong Zhao, Shao-Bo Chen, Jing-Jing Wang, Chao Xu, Ming-Liang Zhao, Hua-Jiang Dong, Hai-Qian Liang, Xiao-Hong Li, Yue Tu, Sai Zhang, Chong Chen, Hong-Tao Sun
Although hypothermic-targeted temperature management (HTTM) holds great potential for the treatment of traumatic brain injury (TBI), translation of the efficacy of hypothermia from animal models to TBI patientshas no entire consistency. This study aimed to find an ideal time window model in experimental rats which was more in accordance with clinical practice through the delayed HTTM intervention. Sprague-Dawley rats were subjected to unilateral cortical contusion injury and received therapeutic hypothermia at 15 mins, 2 hours, 4 hours respectively after TBI...
June 16, 2017: Brain Research
https://www.readbyqxmd.com/read/28628625/neural-progenitor-cell-proliferation-in-the-hypothalamus-is-involved-in-acquired-heat-tolerance-in-long-term-heat-acclimated-rats
#7
Kentaro Matsuzaki, Masanori Katakura, Naotoshi Sugimoto, Toshiko Hara, Michio Hashimoto, Osamu Shido
Constant exposure to moderate heat facilitates progenitor cell proliferation and neuronal differentiation in the hypothalamus of heat-acclimated (HA) rats. In this study, we investigated neural phenotype and responsiveness to heat in HA rats' hypothalamic newborn cells. Additionally, the effect of hypothalamic neurogenesis on heat acclimation in rats was evaluated. Male Wistar rats (5 weeks old) were housed at an ambient temperature (Ta) of 32°C for 6 days (STHA) or 40 days (LTHA), while control (CN) rats were kept at a Ta of 24°C for 6 days (STCN) or 40 days (LTCN)...
2017: PloS One
https://www.readbyqxmd.com/read/28626808/attenuation-of-opioid-tolerance-by-etb-receptor-agonist-irl-1620-is-independent-of-an-accompanied-decrease-in-nerve-growth-factor-in-mice
#8
Shruti Gulati, Seema Briyal, Shantel Jones, Shaifali Bhalla, Anil Gulati
AIM: ETA receptor antagonists reverse opioid tolerance but the involvement of ETB receptors is unknown. In morphine or oxycodone tolerant mice we investigated (1) the effect of ETB receptor agonist, IRL-1620, on analgesic tolerance; (2) changes in expression of the brain ETA and ETB receptors; and (3) alterations in the brain VEGF, NGF, PI3K and notch-1 expression. MAIN METHODS: Body weight, body temperature, and tail-flick latency were assessed before and after a challenge dose of morphine or oxycodone in vehicle or IRL-1620 treated mice...
June 2017: Heliyon
https://www.readbyqxmd.com/read/28624592/post-anoxic-quantitative-mri-changes-may-predict-emergence-from-coma-and-functional-outcomes-at-discharge
#9
Alexandra S Reynolds, Xiaotao Guo, Elizabeth Matthews, Daniel Brodie, Leroy E Rabbani, David J Roh, Soojin Park, Jan Claassen, Mitchell S V Elkind, Binsheng Zhao, Sachin Agarwal
BACKGROUND: Traditional predictors of neurological prognosis after cardiac arrest are unreliable after targeted temperature management. Absence of pupillary reflexes remains a reliable predictor of poor outcome. Diffusion-weighted imaging has emerged as a potential predictor of recovery, and here we compare imaging characteristics to pupillary exam. METHODS: We identified 69 patients who had MRIs within seven days of arrest and used a semi-automated algorithm to perform quantitative volumetric analysis of apparent diffusion coefficient (ADC) sequences at various thresholds...
June 15, 2017: Resuscitation
https://www.readbyqxmd.com/read/28618066/assessment-of-ferritin-content-in-multiple-sclerosis-brains-using-temperature-induced-r-2-changes
#10
Christoph Birkl, Daniele Carassiti, Fariha Hussain, Christian Langkammer, Christian Enzinger, Franz Fazekas, Klaus Schmierer, Stefan Ropele
PURPOSE: Current MRI techniques cannot reliably assess iron content in white matter due to the confounding diamagnetic effect of myelin. The purpose of this study was to validate with histology a novel iron mapping technique that uses the temperature dependency of the paramagnetic susceptibility in multiple sclerosis (MS) brains, where white matter has been reported to show significant variations in iron content. METHODS: We investigated post mortem brain tissue from three MS patients and one control subject...
June 15, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28617423/relationship-between-temperature-variability-and-brain-injury-on-magnetic-resonance-imaging-in-cooled-newborn-infants-after-perinatal-asphyxia
#11
B Brotschi, R Gunny, C Rethmann, U Held, B Latal, C Hagmann
OBJECTIVE: The objective of the study was whether temperature management during therapeutic hypothermia correlates with the severity of brain injury assessed on magnetic resonance imaging in term infants with hypoxic-ischemic encephalopathy. STUDY DESIGN: Prospectively collected register data from the National Asphyxia and Cooling Register of Switzerland were analyzed. RESULT: Fifty-five newborn infants were cooled for 72 h with a target temperature range of 33 to 34 °C...
June 15, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28602745/systemic-estradiol-administration-to-ovariectomized-rats-facilitates-thermoregulatory-behavior-in-a-cold-environment
#12
Yuki Uchida, Kei Nagashima, Kazunari Yuri
Rats place their tails underneath their bodies in the cold (tail-hiding behavior), which is a behavioral indicator of thermoregulation. The aim of the present study was to elucidate the effect of estradiol (E2) on tail-hiding behavior and neural activity assessed by immunohistochemistry. Ovariectomized rats were implanted with a silastic tube with or without E2 underneath the dorsal skin (E2(-) and E2(+) groups), and exposed to 27°C, 16°C, and 10°C for 2h with continuous body temperature (Tb), tail skin temperature (Ttail), and behavioral measurements...
June 9, 2017: Brain Research
https://www.readbyqxmd.com/read/28600679/resting-state-bold-oscillation-frequency-predicts-vigilance-task-performance-at-both-normal-and-high-environmental-temperatures
#13
Xiaopeng Song, Shaowen Qian, Kai Liu, Shuqin Zhou, Huaiqiu Zhu, Qihong Zou, Yijun Liu, Gang Sun, Jia-Hong Gao
Hyperthermia may impair vigilance functions and lead to slower reaction times (RTs) in the psychomotor vigilance task (PVT) and possibly disturbing cerebral hemodynamic rhythms. To test these hypotheses, we acquired the resting-state BOLD and cerebral blood flow (CBF) data, as well as PVTRTs from 15 participants in two simulated environmental thermal conditions (50 °C/25 °C). We adopted a data-driven method, frequency component analysis, to quantify the mean frequency of the BOLD series of each voxel. Across-subject correlation analysis was employed to detect the brain areas whose BOLD oscillation frequency was correlated with the RTs...
June 9, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28598695/unconventional-roles-of-opsins
#14
Nicole Y Leung, Craig Montell
Rhodopsin is the classical light sensor. Although rhodopsin has long been known to be important for image formation in the eye, the requirements for opsins in non-image formation and in extraocular light sensation were revealed much later. Most recent is the demonstration that an opsin in the fruit fly, Drosophila melanogaster, is expressed in pacemaker neurons in the brain and functions in light entrainment of circadian rhythms. However, the biggest surprise is that opsins have light-independent roles, countering more than a century of dogma that they function exclusively as light sensors...
June 9, 2017: Annual Review of Cell and Developmental Biology
https://www.readbyqxmd.com/read/28597974/a-simple-cell-transport-device-keeps-culture-alive-and-functional-during-shipping
#15
Paula G Miller, Ying I Wang, Glen Swan, Michael L Shuler
Transporting living complex cellular constructs through the mail while retaining their full viability and functionality is challenging. During this process, cells often suffer from exposure to suboptimal life-sustaining conditions (e.g. temperature, pH), as well as damage due to shear stress. We have developed a transport device for shipping intact cell/tissue constructs from one facility to another that overcomes these obstacles. Our transport device maintained three different cell lines (Caco2, A549, and HepG2 C3A) individually on transwell membranes with high viability (above 97%) for 48 h under simulated shipping conditions without an incubator...
June 9, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28596466/-clocks-behavior-and-cognition
#16
Akinori Futamura, Azusa Shiromaru, Takeshi Kuroda, Motoyasu Honma, Ryuta Kinno, Kenjiro Ono, Mitsuru Kawamura
The nerve center responsible for controlling our circadian rhythm is located in a cluster of cells known as the suprachiasmatic nucleus in the hypothalamus. Various physiological functions such as sleep, arousal, blood pressure, body temperature, and hormone secretion are regulated in a 24-hour rhythm by this circuit. Somatic cells of other organs have a peripheral clock gene and by synchronizing the rhythm of the central and peripheral clocks, it is possible to live a healthy life. Due to aging and degenerative disease, circadian rhythm gradually collapses...
June 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28593192/intravenous-heroin-induces-rapid-brain-hypoxia-and-hyperglycemia-that-precede-brain-metabolic-response
#17
Ernesto Solis, Keaton T Cameron-Burr, Yavin Shaham, Eugene A Kiyatkin
Heroin use and overdose have increased in recent years as people transition from abusing prescription opiates to using the cheaper street drug. Despite a long history of research, many physiological effects of heroin and their underlying mechanisms remain unknown. Here, we used high-speed amperometry to examine the effects of intravenous heroin on oxygen and glucose levels in the nucleus accumbens (NAc) in freely-moving rats. Heroin within the dose range of human drug use and rat self-administration (100-200 μg/kg) induced a rapid, strong, but transient drop in NAc oxygen that was followed by a slower and more prolonged rise in glucose...
May 2017: ENeuro
https://www.readbyqxmd.com/read/28589556/characterization-of-functional-%C3%AE-opioid-receptor-turnover-in-rat-locus-coeruleus-an-electrophysiological-and-immunocytochemical-study
#18
María Carmen Medrano, María Teresa Santamarta, Patricia Pablos, Zigor Aira, Itsaso Buesa, Jon Jatsu Azkue, Aitziber Mendiguren, Joseba Pineda
BACKGROUND AND PURPOSE: Regulation of μ receptor (MOR) dynamics such as MOR trafficking is a possible mechanism underlying opioid tolerance that contributes to inefficient recycling of opioid responses. We aimed to characterize the functional MOR turnover in the noradrenergic nucleus locus coeruleus (LC). EXPERIMENTAL APPROACH: We measured opioid effect by single-unit extracellular recordings of LC neurons from rat brain slices. Immunocytochemical techniques were also used to evaluate MOR trafficking...
June 7, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28587193/stability-of-bdnf-in-human-samples-stored-up-to-6-months-and-correlations-of-serum-and-edta-plasma-concentrations
#19
Maryna Polyakova, Haiko Schlögl, Julia Sacher, Maren Schmidt-Kassow, Jochen Kaiser, Michael Stumvoll, Jürgen Kratzsch, Matthias L Schroeter
Brain-derived neurotrophic factor (BDNF), an important neural growth factor, has gained growing interest in neuroscience, but many influencing physiological and analytical aspects still remain unclear. In this study we assessed the impact of storage time at room temperature, repeated freeze/thaw cycles, and storage at -80 °C up to 6 months on serum and ethylenediaminetetraacetic acid (EDTA)-plasma BDNF. Furthermore, we assessed correlations of serum and plasma BDNF concentrations in two independent sets of samples...
June 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28582931/a-surface-acoustic-wave-icp-sensor-with-good-temperature-stability
#20
Bing Zhang, Hong Hu, Aipeng Ye, Peng Zhang
BACKGROUND: Intracranial pressure (ICP) monitoring is very important for assessing and monitoring hydrocephalus, head trauma and hypertension patients, which could lead to elevated ICP or even devastating neurological damage. The mortality rate due to these diseases could be reduced through ICP monitoring, because precautions can be taken against the brain damage. OBJECTIVE: This paper presents a surface acoustic wave (SAW) pressure sensor to realize ICP monitoring, which is capable of wireless and passive transmission with antenna attached...
May 26, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
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