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https://www.readbyqxmd.com/read/29150776/hyperpyrexia-as-the-presenting-symptom-of-intracranial-hypotension
#1
Omar Hussein, Michel Torbey
INTRODUCTION: Hyperpyrexia is a severely elevated core body temperature secondary to an elevated hypothalamic set thermo-regulatory threshold. Hyperthermia is an elevated core body temperature beyond the normal hypothalamic set thermo-regulatory threshold. Intracranial hypotension can present with a wide variety of symptoms ranging from orthostatic headache up to coma. We report a rare case of hyperpyrexia associated with intracranial hypotension. METHODS: A case report of a 55-year-old female patient with a history of angiogram-negative subarachnoid hemorrhage status post-ventriculoperitoneal (VP) shunt placement six years prior to admission who suddenly developed encephalopathy and high fever...
November 17, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/29147638/a-sensitive-and-rapid-method-for-detecting-formaldehyde-in-brain-tissues
#2
Xiangpei Yue, Yaoyue Zhang, Wen Xing, Yutong Chen, Chenyang Mu, Zhan Miao, Peichun Ge, Tingting Li, Rongqiao He, Zhiqian Tong
The existing methods for detecting formaldehyde (FA) in brain samples are expensive and require sophisticated experimental procedures. Here, we established a highly sensitive and selective spectrophotometric method, which is based on a reaction in which FA reacts with colorless reagent 4-amino-3-penten-2-one (Fluoral-P) to produce a yellow compound, 3,5-diacetyl-1,4-dihydrolutidine (DDL), which can be detected by a spectrophotometer at 420 nm at room temperature. The sensitive response time point was found to be at the first hour, and the optimal pH of derivative reaction was pH 6...
2017: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/29142341/in-house-preparation-and-quality-control-of-tc99m-trodat-1-for-diagnostic-single-photon-emission-computed-tomography-computed-tomography-imaging-in-parkinson-s-disease
#3
Rakhee Vatsa, Jaya Shukla, Bhagwant Rai Mittal, Apurva Sood, Raman Kumar Joshi, Kanchan Palarwal, Priya Bhusari, Manish Modi
Purpose of Study: Loss of dopamine neurons in the brain is a characteristic feature of Parkinson's disease (PD). TRODAT-1 is a tropane derivative that binds to dopamine transporter (DAT) receptors. It can be used for noninvasive in vivo imaging of DAT receptors leading to the early detection of PD. The present study aims to optimize the in-house radiolabeling of TRODAT-1 with Tc-99 m in hospital radiopharmacy set up along with performing single-photon emission computed tomography/computed tomography imaging in patients with PD...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29141517/protective-effects-of-dietary-omega-3-fatty-acid-supplementation-on-organophosphate-poisoning
#4
Bahattin Avci, S Sirri Bilge, Gokhan Arslan, Omer Alici, Ozge Darakci, Turkhan Baratzada, Engin Ciftcioglu, Turker Yardan, Ayhan Bozkurt
In this study, we aimed to study the possible preventive effect of docosahexaenoic acid (DHA), a dietary omega-3 fatty acid, on toxicity caused by chlorpyrifos (CPF). Six groups of Sprague Dawley rats (200-250 g) consisting of equal numbers of males and females (n = 8) were assigned to study. The rats were orally given for 5 days. The control group was administered pure olive oil, which was the vehicle for CPF. The CPF challenge groups were administered oral physiological saline, pure olive oil, or DHA (50, 100 and 400 mg/kg dosages) for 5 days...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/29138467/bacillus-classification-based-on-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-effects-of-culture-conditions
#5
Lin-Jie Shu, Yu-Liang Yang
Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a reliable and rapid technique applied widely in the identification and classification of microbes. MALDI-TOF MS has been used to identify many endospore-forming Bacillus species; however, endospores affect the identification accuracy when using MALDI-TOF MS because they change the protein composition of samples. Since culture conditions directly influence endospore formation and Bacillus growth, in this study we clarified how culture conditions influence the classification of Bacillus species by using MALDI-TOF MS...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29135501/temperature-variability-in-a-modern-targeted-temperature-management-trial
#6
Ahmad Abu-Arafeh, Aryelly Rodriguez, Ross L Paterson, Peter J D Andrews
OBJECTIVES: The Eurotherm3235 trial showed that therapeutic hypothermia was deleterious in patients with raised intracranial pressure following traumatic brain injury. We sought to ascertain if increased temperature variability within the first 48 hours, or for 7 days post randomization, were modifiable risk factors associated with poorer outcome. DESIGN: Eurotherm3235 was a multicenter randomized controlled trial. Patients were randomized to receive either therapeutic hypothermia in addition to standard care or the later only...
November 10, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29132009/temperature-and-metal-exposure-affect-membrane-fatty-acid-composition-and-transcription-of-desaturases-and-elongases-in-fathead-minnow-muscle-and-brain
#7
Mariem Fadhlaoui, Fabien Pierron, Patrice Couture
In this study, we tested the hypothesis that metal exposure affected the normal thermal response of cell membrane FA composition and of elongase and desaturase gene transcription levels. To this end, muscle and brain membrane FA composition and FA desaturase (fads2, degs2 and scd2) and elongase (elovl2, elovl5 and elovl6) gene transcription levels were analyzed in fathead minnows (Pimephales promelas) acclimated for eight weeks to 15, 25 or 30°C exposed or not to cadmium (Cd, 6μg/l) or nickel (Ni, 450 6μg/l)...
November 10, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29131171/application-of-spatially-modulated-near-infrared-structured-light-to-study-changes-in-optical-properties-of-mouse-brain-tissue-during-heatstress
#8
Oren Shaul, Michal Fanrazi-Kahana, Omri Meitav, Gad A Pinhasi, David Abookasis
Heat stress (HS) is a medical emergency defined by abnormally elevated body temperature that causes biochemical, physiological, and hematological changes. The goal of the present research was to detect variations in optical properties (absorption, reduced scattering, and refractive index coefficients) of mouse brain tissue during HS by using near-infrared (NIR) spatial light modulation. NIR spatial patterns with different spatial phases were used to differentiate the effects of tissue scattering from those of absorption...
November 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29129925/the-neural-basis-of-homeostatic-and-anticipatory-thirst
#9
REVIEW
Claire Gizowski, Charles W Bourque
Water intake is one of the most basic physiological responses and is essential to sustain life. The perception of thirst has a critical role in controlling body fluid homeostasis and if neglected or dysregulated can lead to life-threatening pathologies. Clear evidence suggests that the perception of thirst occurs in higher-order centres, such as the anterior cingulate cortex (ACC) and insular cortex (IC), which receive information from midline thalamic relay nuclei. Multiple brain regions, notably circumventricular organs such as the organum vasculosum lamina terminalis (OVLT) and subfornical organ (SFO), monitor changes in blood osmolality, solute load and hormone circulation and are thought to orchestrate appropriate responses to maintain extracellular fluid near ideal set points by engaging the medial thalamic-ACC/IC network...
November 13, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29125053/twenty-minutes-of-normothermic-cardiac-arrest-in-a-pig-model-the-role-of-short-term-hypothermia-for-neurological-outcome
#10
Katharina Foerster, Christoph Benk, Friedhelm Beyersdorf, Heidi Cristina Schmitz, Karin Wittmann, Itumeleng Taunyane, Claudia Heilmann, Georg Trummer
INTRODUCTION: Cardiopulmonary resuscitation restores circulation, but with inconsistent blood-flow and pressures. Our recent approach using an extracorporeal life support system, named "controlled integrated resuscitation device" (CIRD), may lead to improved survival and neurological recovery after cardiac arrest (CA). The basic idea is to provide a reperfusion tailored to the individual patient by control of the conditions of reperfusion and the composition of the reperfusate. Hypothermia is one aspect of this concept...
November 1, 2017: Perfusion
https://www.readbyqxmd.com/read/29123858/development-of-new-equipment-for-intra-arrest-brain-cooling-that-uses-cooled-oxygen-in-the-lungs-volunteer-study
#11
Atsushi Sakurai, Rumi Tagami, Shingo Ihara, Junko Yamaguchi, Atsunori Sugita, Nami Sawada, Tomohide Komatsu, Satoshi Hori, Kosaku Kinoshita
Aims: Many experimental studies have reported that intra-arrest cooling during cardiac arrest is a promising treatment to mitigate brain injury. However, there is no clinically established method for cooling the brain during cardiac arrest. We hypothesized that, as blood flow in the lungs must be very slow during cardiopulmonary resuscitation, the blood could be cooled by ventilating the lungs with cooled oxygen like a radiator, and that this cooled blood would in turn cool the brain...
April 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29121947/interleukin-1%C3%AE-signaling-in-fenestrated-capillaries-is-sufficient-to-trigger-sickness-responses-in-mice
#12
J Gabriel Knoll, Stephanie M Krasnow, Daniel L Marks
BACKGROUND: The physiological and behavioral symptoms of sickness, including fever, anorexia, behavioral depression, and weight loss can be both beneficial and detrimental. These sickness responses are triggered by pro-inflammatory cytokines acting on cells within the brain. Previous research demonstrates that the febrile response to peripheral insults depends upon prostaglandin production by vascular endothelial cells, but the mechanisms and specific cell type(s) responsible for other sickness responses remain unknown...
November 9, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29118201/inflow-of-oxygen-and-glucose-into-brain-tissue-induced-by-intravenous-norepinephrine-relationships-with-central-metabolic-and-peripheral-vascular-responses
#13
R Aaron Bola, Eugene A Kiyatkin
As an essential part of sympathetic activation that prepares the organism for "fight or flight," peripheral norepinephrine (NE) plays an important role in regulating cardiac activity and the tone of blood vessels, increasing blood flow to the heart and the brain and decreasing blood flow to the organs not as necessary for immediate survival. To assess whether this effect is applicable to the brain, we used high-speed amperometry to measure the changes in nucleus accumbens (NAc) levels of oxygen and glucose induced by intravenous (iv) injections of NE in awake, freely-moving rats...
November 8, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29115692/a-spiral-based-volumetric-acquisition-for-mr-temperature-imaging
#14
Samuel W Fielden, Xue Feng, Li Zhao, G Wilson Miller, Matthew Geeslin, Robert F Dallapiaza, W Jeffrey Elias, Max Wintermark, Kim Butts Pauly, Craig H Meyer
PURPOSE: To develop a rapid pulse sequence for volumetric MR thermometry. METHODS: Simulations were carried out to assess temperature deviation, focal spot distortion/blurring, and focal spot shift across a range of readout durations and maximum temperatures for Cartesian, spiral-out, and retraced spiral-in/out (RIO) trajectories. The RIO trajectory was applied for stack-of-spirals 3D imaging on a real-time imaging platform and preliminary evaluation was carried out compared to a standard 2D sequence in vivo using a swine brain model, comparing maximum and mean temperatures measured between the two methods, as well as the temporal standard deviation measured by the two methods...
November 8, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29111855/neuroprotective-effects-of-inhibitors-of-acid-sensing-ion-channels-asics-in-optic-nerve-crush-model-in-rodents
#15
Dorota L Stankowska, Brett H Mueller, Hidehiro Oku, Tsunehiko Ikeda, Adnan Dibas
PURPOSE: The purpose of the current study was to assess the potential involvement of acid-sensing ion channel 1 (ASIC1) in retinal ganglion cell (RGC) death and investigate the neuroprotective effects of inhibitors of ASICs in promoting RGC survival following optic nerve crush (ONC). RESULTS: ASIC1 protein was significantly increased in optic nerve extracts at day 7 following ONC in rats. Activated calpain-1 increased at 2 and 7 days following ONC as evidenced by increased degradation of α-fodrin, known substrate of calpain...
November 7, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29108554/oxidative-stress-and-antioxidant-defense-responses-of-etroplus-suratensis-to-acute-temperature-fluctuations
#16
Susan Joy, Aneesa Painadath Alikunju, Jisha Jose, Hari Sankar Haridasanpillai Sudha, Prabhakaran Meethal Parambath, Sajeevan Thavarool Puthiyedathu, Babu Philip
Fishes are always exposed to various environmental stresses and the chances of succumbing to such stresses are of great physiological concern. Any change in temperature from the ambient condition can induce various metabolic and physiological changes in the body. The present study evaluates the effects of temperature induced stress on the antioxidant profile of Etroplus suratensis such as superoxide dismutase, catalase, glutathione peroxidase and lipid peroxidation. Fishes of same size were kept in a thermostatized bath at three different temperature regimes viz 16°C, 27°C (ambient temperature) and 38°C for 72h...
December 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29108477/hyperthermia-and-mild-traumatic-brain-injury-effects-on-inflammation-and-the-cerebral-vasculature
#17
Jessie Truettner, Helen M Bramlett, W Dalton Dietrich
Mild traumatic brain injury (mTBI) or concussion represents the majority of TBIs brain trauma in the United States. The pathophysiology of mTBI is complex and may include both focal and diffuse injury patterns. In addition to altered circuit dysfunction and diffuse traumatic axonal injury (DTAI), chronic neuroinflammation has also been implicated in the pathophysiology of mTBI. Recently, our laboratory has reported the detrimental effects of mild hyperthermic mTBI in terms of worsening histopathological and behavioral outcomes...
November 6, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29106909/a-study-of-bio-hybrid-silsesquioxane-yeast-biosorption-and-neuronal-toxicity-of-lead
#18
Bianca Trama-Freitas, Johnattan C S Freitas, Rui C Martins, Licínio M Gando-Ferreira, Maria Emília Quinta-Ferreira, Rosa Maria Quinta-Ferreira, Devaney R do Carmo
Lead is a heavy metal of high impact for the environment as well as for human health, being cause of several diseases. Considering the importance of obtaining an effective treatment for lead removal, a new hybrid material was developed for sorption of Pb(2+) from aqueous solution. The effect of pH, temperature, liquid/solid ratio (g/cm(3)) and lead concentration on the sorption capacity of yeasts chemically modified with cubic silsesquioxane (YS) was analyzed. Additionally, the toxicity of lead on the neuronal activity was also investigated in order to assess whether the damage caused by the Pb(2+) ion is reversible or not...
October 26, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/29101256/climatic-and-seasonal-circumstances-of-hypertensive-intracerebral-hemorrhage-in-a-worldwide-cohort
#19
Christian Herweh, Stefan Nordlohne, Marek Sykora, Lorenz Uhlmann, Martin Bendszus, Thorsten Steiner
BACKGROUND AND PURPOSE: Numerous studies have investigated the influence of meteorologic factors and seasons on the incidence of spontaneous intracerebral hemorrhage (ICH) with ambiguous results. In the present study, data from a large, international multicenter trial in patients with ICH were used to identify seasonal and meteorologic determinants for hypertensive-ICH with greater applicability. METHODS: Patients were grouped according to the presumptive ICH cause, that is, hypertensive when located in the basal ganglia brain stem as well as cerebellum and nonhypertensive when located lobar...
November 3, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29099343/feasibility-study-of-a-novel-high-flow-cold-air-cooling-protocol-of-the-porcine-brain-using-mri-temperature-mapping
#20
Jan Sedlacik, Åsmund Kjørstad, Zsuzsanna Nagy, Jan-Hendrik Buhk, Christoph R Behem, Constantin J Trepte, Jens Fiehler, Fabian Temme
Early, prehospital cooling seeks to reduce and control the body temperature as early as possible to protect the brain and improve patient outcome in cardiac arrest, stroke, and traumatic brain injury. In this study, we investigate the feasibility of localized cooling of the porcine brain by using a novel high-flow cold air protocol, which utilizes the close proximity between the nasal cavity and the brain. Five adult pigs were anesthetized and temperature change was mapped before, during, and after cooling by using the proton resonance frequency method on a 3 T Siemens Magnetom Skyra system...
November 3, 2017: Therapeutic Hypothermia and Temperature Management
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