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https://www.readbyqxmd.com/read/29666206/taurine-supplementation-for-prevention-of-stroke-like-episodes-in-melas-a-multicentre-open-label-52-week-phase-iii-trial
#1
Yutaka Ohsawa, Hiroki Hagiwara, Shin-Ichiro Nishimatsu, Akihiro Hirakawa, Naomi Kamimura, Hideaki Ohtsubo, Yuta Fukai, Tatsufumi Murakami, Yasutoshi Koga, Yu-Ichi Goto, Shigeo Ohta, Yoshihide Sunada
OBJECTIVE: The aim of this study was to evaluate the efficacy and safety of high-dose taurine supplementation for prevention of stroke-like episodes of MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes), a rare genetic disorder caused by point mutations in the mitochondrial DNA that lead to a taurine modification defect at the first anticodon nucleotide of mitochondrial tRNALeu(UUR) , resulting in failure to decode codons accurately. METHODS: After the nationwide survey of MELAS, we conducted a multicentre, open-label, phase III trial in which 10 patients with recurrent stroke-like episodes received high-dose taurine (9 g or 12 g per day) for 52 weeks...
April 17, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29663975/gingival-enlargement-caused-by-vitamin-c-deficiency-scurvy-in-a-boy
#2
Adesh Kakade, Mugdha S Raut, Anitha Santosh, Saurabh Nagar, Shivani Bansal, Rajiv S Desai
Localized gingival enlargement associated with vitamin C deficiency (scurvy) is rarely encountered in the modern era. The purpose of this paper is to report a case of extensive inflammatory gingival enlargement in the mandibular anterior region associated with vitamin C deficiency in a 10 year-old boy. There was a significant improvement of the gingival enlargement seven days after starting oral vitamin C supplementation. Vitamin C deficiency should be included in the differential diagnosis of any gingival enlargement, especially in children...
January 15, 2018: Journal of Dentistry for Children
https://www.readbyqxmd.com/read/29661838/chronic-supplementation-with-a-mitochondrial-antioxidant-mitoq-improves-vascular-function-in-healthy-older-adults
#3
Matthew J Rossman, Jessica R Santos-Parker, Chelsea A C Steward, Nina Z Bispham, Lauren M Cuevas, Hannah L Rosenberg, Kayla A Woodward, Michel Chonchol, Rachel A Gioscia-Ryan, Michael P Murphy, Douglas R Seals
Excess reactive oxygen species production by mitochondria is a key mechanism of age-related vascular dysfunction. Our laboratory has shown that supplementation with the mitochondrial-targeted antioxidant MitoQ improves vascular endothelial function by reducing mitochondrial reactive oxygen species and ameliorates arterial stiffening in old mice, but the effects in humans are unknown. Here, we sought to translate our preclinical findings to humans and determine the safety and efficacy of MitoQ. Twenty healthy older adults (60-79 years) with impaired endothelial function (brachial artery flow-mediated dilation <6%) underwent 6 weeks of oral supplementation with MitoQ (20 mg/d) or placebo in a randomized, placebo-controlled, double-blind, crossover design study...
April 16, 2018: Hypertension
https://www.readbyqxmd.com/read/29661746/effects-of-oral-vitamin-d-3-supplementation-in-stage-3-chronic-kidney-disease-subjects-insulin-resistance-syndrome-and-hormonal-disturb-interactions
#4
Amina Tahar, Faiza Zerdoumi, Messaoud Saidani, Lakhdar Griene, Elhadj-Ahmed Koceir
The 1-25-hydroxyvitamine D (1-25OHD) or calcitriol deficiency in chronic kidney disease (CKD) patients was associated with increases vascular calcification risk, nephrons reduction, bone deficit and cardiovascular mortality by atherosclerosis. The objective of this study was to investigate the pleiotropic effects of 200.000 IU (D200 group) every 3 months versus 30.000 IU (D30 group) every month dose vitamin D supplementation in stage 3 CKD patients. A cohort of 132 adult subjects was randomized into 2 groups according to dose vitamin D supplementation in deficient subjects (25OHD <50 nmol/L or <20 ng/mL)...
April 16, 2018: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29661446/multivisceral-transplantation-rehabilitation-program-case-report
#5
T M Loschi, M P R G Cinacchi, M D T A Baccan, F Marques, P T Pedroso, S P Meira Filho, T Scacchetti, D N Pavão
Multivisceral transplantation is the treatment for multiple abdominal organ failure. The patient experiences reduced food intake and absorption of nutrients, contributing to weight loss and decreased muscle mass, reducing functional capacity. A physical and nutritional rehabilitation program based on adequate caloric intake associated with supervised physical exercise seems to support a gain of muscle mass, re-establishing its capacity and functional independence. A rehabilitation program was carried out, consisting of low-intensity aerobic exercise on treadmill, exercises of global strengthening (50% of 1 maximum repetition [1RM], with progressive increase), and nutritional monitoring (oral hypercaloric diet, hyperproteic supplementation daily and after exercise)...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29660814/effects-of-cd36-genotype-on-oral-perception-of-oleic-acid-supplemented-safflower-oil-emulsions-in-two-ethnic-groups-a-preliminary-study
#6
Brenda Burgess, Melania Melis, Katelyn Scoular, Michael Driver, Karen M Schaich, Kathleen L Keller, Iole Tomassini Barbarossa, Beverly J Tepper
Previous studies demonstrate humans can detect fatty acids via specialized sensors on the tongue, such as the CD36 receptor. Genetic variation at the common single nucleotide polymorphism rs1761667 of CD36 has been shown to differentially impact the perception of fatty acids, but comparative data among different ethnic groups are lacking. In a small cohort of Caucasian and East Asian young adults, we investigated if: (1) participants could detect oleic acid (C18:1) added to safflower oil emulsions at a constant ratio of 3% (w/v); (2) supplementation of oleic acid to safflower oil emulsions enhanced perception of fattiness and creaminess; and (3) variation at rs1761667 influenced oleic acid detection and fat taste perception...
April 16, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29660761/interactions-of-dihydromyricetin-a-flavonoid-from-vine-tea-ampelopsis-grossedentata-with-gut-microbiota
#7
Li Fan, Xinyuan Zhao, Qing Tong, Xiya Zhou, Jing Chen, Wei Xiong, Jianguo Fang, Wenqing Wang, Chunyang Shi
Dihydromyricetin (DMY) is the main bioactive constituent in vine tea (Ampelopsis grossedentata), which was predominantly distributed in the gastrointestinal tract and showed poor oral bioavailability. Our aim was to systematically investigate the interactions of DMY with gut microbiota. Through the metabolism study of DMY by fecal microflora in vitro, it was found that DMY could be metabolized into three metabolites by fecal microflora via reduction and dehydroxylation pathways, and the dehydroxylation metabolite was the dominant one...
April 16, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29658597/antitumoral-effect-of-ocoxin-a-natural-compound-containing-nutritional-supplement-in-small-cell-lung-cancer
#8
Elena Díaz-Rodríguez, Eduardo Sanz, Atanasio Pandiella
Lung cancer is the most frequently diagnosed neoplasia and represents the leading cause of cancer-related deaths worldwide. Due to this fact, efforts to improve patient survival through the introduction of novel therapies, as well as preventive actions, are urgently required. Considering this scenario, the antitumoral action of the composite formulation Ocoxin® oral solution (OOS), that contains several antitumoral compounds including antioxidants, was tested in small cell lung cancer (SCLC) in vitro and in vivo preclinical models...
April 16, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29658538/-effectiveness-of-oral-nutritional-supplements-to-prevent-hospital-malnutrition-overview-of-systematic-reviews
#9
Luca Giuseppe Re, Maura Lusignani
. Effectiveness of oral nutritional supplements to prevent hospital malnutrition. Overview of systematic reviews. INTRODUCTION: Although oral nutritional supplements (ONSs) are among most popular interventions to prevent a condition of hospital malnutrition, their real benefits need to be clarified. AIM: To evaluate in adults the effectiveness of ONSs to prevent hospital malnutrition. METHODS: Papers retrieval by querying biomedical databases The Cochrane Library, Medline, Embase, CINAHL...
January 2018: Assistenza Infermieristica e Ricerca: AIR
https://www.readbyqxmd.com/read/29657592/design-and-baseline-characteristics-of-the-xarelto-post-authorization-safety-effectiveness-study-in-japanese-patients-with-atrial-fibrillation-xapass
#10
Satoshi Ogawa, Kazuo Minematsu, Takanori Ikeda, Takanari Kitazono, Jyoji Nakagawara, Susumu Miyamoto, Yuji Murakawa, Yohei Ohashi, Makiko Takeichi, Yutaka Okayama, Satoshi Yamanaka, Lyo Inuyama
Background: The phase III Japanese Rivaroxaban Once-Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (J-ROCKET AF) showed that the rivaroxaban group had a lower event rate of intracranial bleeding than the warfarin group and that rivaroxaban was noninferior to warfarin for the principal safety outcome. However, safety and effectiveness data from unselected patients with AF in everyday clinical practice in Japan are lacking...
April 2018: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29656997/veterinary-parasitology-teaching-at-london-meeting-the-day-one-competency-needs-of-new-veterinarians
#11
Mark Fox, Damer Blake, Dennis Jacobs
Over the past four decades, there has been an exponential increase in veterinary parasitology knowledge, coinciding with the advent of molecular biology in research. Therefore, it is unrealistic for teachers to expect students to graduate with an encyclopaedic knowledge of the subject. As a result, a new curriculum was introduced at The Royal Veterinary College (University of London) in 2007, designed to meet the needs of our new graduates, i.e. RCVS Day-One Competences. The aims of this curriculum are, inter alia, to ensure that new graduates have an up-to-date body of core knowledge and are able to apply such knowledge and newly-acquired information to scientific and clinical problem-solving...
April 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29656214/study-of-virulence-factor-of-candida-species-in-oral-lesions-and-its-association-with-potentially-malignant-and-malignant-lesions
#12
Graciela Del Valle Castillo, Silvia López de Blanc, Claudia Elena Sotomayor, Ana Isabel Azcurra
OBJECTIVE: The aim of this study was to explore the association between malignant and premalignant lesions and the virulence factor profile of Candida spp. recovered from different oral lesions. DESIGN: Candida spp. isolated from malignant lesions (squamous cell carcinoma, OC, n = 25), atypical lichen planus (AL, n = 11), chronic candidiasis (CC, n = 25), and asymptomatic carriers (WI, n = 15, control strains.) Isolates were identified in chromogenic medium, colony morphology and biochemical tests...
February 19, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29655406/aggregatibacter-actinobacillus-actimycetemcomitans-leukotoxin-and-human-periodontitis-a-historic-review-with-emphasis-on-jp2
#13
REVIEW
Chi-Cheng Tsai, Ya-Ping Ho, Yu-Shian Chou, Kun-Yen Ho, Yi-Min Wu, Ying-Chu Lin
Aggregatibacter (Actinobacillus) actimycetemcomitans (Aa) is a gram-negative bacterium that colonizes the human oral cavity and is causative agent for localized aggressive (juvenile) periodontitis (AgP). In the middle of 1990s, a specific JP2 clone of belonging to the cluster of serotype b strains of Aa with highly leukotoxicity (leukotoxin, LtxA) able to kill human immune cells was isolated. JP2 clone of Aa was strongly associated with in particularly in rapidly progressing forms of aggressive periodontitis...
April 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29652551/n-3-fatty-acid-supplementation-for-the-treatment-of-dry-eye-disease
#14
(no author information available yet)
Background Dry eye disease is a common chronic condition that is characterized by ocular discomfort and visual disturbances that decrease quality of life. Many clinicians recommend the use of supplements of n-3 fatty acids (often called omega-3 fatty acids) to relieve symptoms. Methods In a multicenter, double-blind clinical trial, we randomly assigned patients with moderate-to-severe dry eye disease to receive a daily oral dose of 3000 mg of fish-derived n-3 eicosapentaenoic and docosahexaenoic acids (active supplement group) or an olive oil placebo (placebo group)...
April 13, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29648878/protective-effect-of-lactobacillus-reuteri-dsm-17938-against-experimental-necrotizing-enterocolitis-is-mediated-by-toll-like-receptor-2
#15
Thomas K Hoang, Baokun He, Ting Wang, Dat Q Tran, Jon Marc Rhoads, Yuying Liu
Lactobacillus reuteri DSM 17938 (LR 17938) has been shown to reduce the incidence and severity of necrotizing enterocolitis (NEC). It is unclear if preventing NEC by LR 17938 is mediated by toll-like receptor 2 (TLR2), which is known to mediate pro-inflammatory responses to bacterial cell wall components. NEC was induced in newborn TLR2-/- or WT mice by the combination of gavage-feeding cow milk-based formula and exposure to hypoxia and cold stress. Treatment groups were administered formula supplemented with LR 17938 or placebo (MRS media)...
April 12, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29644961/high-intensity-exercise-induced-intestinal-damage-is-protected-by-fermented-milk-supplemented-with-whey-protein-probiotic-and-pomegranate-punica-granatum-l
#16
Fernanda M Chaves, Igor L Baptista, Fernando M Simabuco, Paula G F Quaresma, Fabiola L Pena, Rosangela M N Bezerra, Jose R Pauli, Diogo T da Cunha, Patricia L Campos-Ferraz, Adriane E C Antunes
Here we evaluated the effect of fermented milk supplemented with whey protein (approximately 80 % protein), probiotic (Bifidobacterium animalis subsp. lactis BB12) and pomegranate juice (Punica granatum L.) on the physical performance, intestinal motility and villi structure, inflammatory markers and intestinal microbiota of rats under high-intensity acute exercise. In all, twenty-four Wistar rats were separated into groups: control (Ctrl), supplemented (Supp), exercised (Exe) and exercised and supplemented (Exe+Supp)...
April 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29644956/genetic-polymorphisms-of-key-enzymes-in-folate-metabolism-affect-the-efficacy-of-folate-therapy-in-patients-with-hyperhomocysteinaemia
#17
Binghui Du, Huizi Tian, Dandan Tian, Chengda Zhang, Wenhua Wang, Lianke Wang, Mengying Ge, Quanliang Hou, Weidong Zhang
The aim of this study is to analyse the efficacy rate of folate for the treatment of hyperhomocysteinaemia (HHcy) and to explore how folate metabolism-related gene polymorphisms change its efficacy. This study also explored the effects of gene-gene and gene-environment interactions on the efficacy of folate. A prospective cohort study enrolling HHcy patients was performed. The subjects were treated with oral folate (5 mg/d) for 90 d. We analysed the efficacy rate of folate for the treatment of HHcy by measuring homocysteine (Hcy) levels after treatment...
April 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29644468/-pharmacological-treatment-of-osteoarthritis-related-pain
#18
REVIEW
T A Nees, M Schiltenwolf
Joint pain due to osteoarthritis (OA) is often severe and disabling and affects a large proportion of the aging population impairing daily living and quality of life. Numerous pharmacological treatment approaches are available. Including major OA guidelines this review presents the current evidence of pharmacological therapies in OA-related pain and covers topical, oral and intraarticular treatment approaches. In patients with mild OA topical nonsteroidal antiinflammatory drugs (NSAIDs) can be recommended...
April 11, 2018: Der Schmerz
https://www.readbyqxmd.com/read/29643159/role-of-iodine-containing-multivitamins-during-pregnancy-for-children-s-brain-function-protocol-of-an-ongoing-randomised-controlled-trial-the-swiddich-study
#19
Sofia Manousou, Birgitta Johansson, Anna Chmielewska, Janna Eriksson, Kerstin Gutefeldt, Carl-Johan Tornhage, Robert Eggertsen, Helge Malmgren, Lena Hulthen, Magnus Domellöf, Helena Nystrom Filipsson
INTRODUCTION: Iodine is essential for normal brain development. Moderate and severe fetal iodine deficiency results in substantial to serious developmental delay in children. Mild iodine deficiency in pregnancy is associated with neurodevelopmental deficits in the offspring, but evidence from randomised trials is lacking. The aim of the Swedish Iodine in Pregnancy and Development in Children study is to determine the effect of daily supplementation with 150 µg iodine during pregnancy on the offspring's neuropsychological development up to 14 years of age...
April 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29642683/effect-of-lactobacillus-salivarius-on-growth-performance-diarrhea-incidence-fecal-bacterial-population-and-intestinal-morphology-of-suckling-pigs-challenged-with-f4-enterotoxigenic-escherichia-coli
#20
Harutai Sayan, Pornchalit Assavacheep, Kris Angkanaporn, Anongnart Assavacheep
Objective: Gut health improvements were monitored with respect to growth performance, diarrhea incidence, fecal bacterial population and intestinal morphology of suckling pigs orally supplemented with live Lactobacillus salivarius oral suspensions and challenged with F4+ enterotoxigenic Escherichia coli (ETEC). Methods: Two groups of newborn pigs from 18 multiparous sows were randomly designated as non-supplemented (control: n=114 piglets) and L. salivarius supplemented groups (treatment: n=87 piglets)...
April 12, 2018: Asian-Australasian Journal of Animal Sciences
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