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https://www.readbyqxmd.com/read/28916655/tethering-il2-to-its-receptor-il2r%C3%AE-enhances-anti-tumor-activity-and-expansion-of-natural-killer-nk92-cells
#1
Youssef Jounaidi, Joseph F Cotten, Keith W Miller, Stuart A Forman
Interleukin-2 (IL2) is an immunostimulatory cytokine for key immune cells including T cells and natural killer (NK) cells. Systemic IL2 supplementation could enhance NK-mediated immunity in a variety of diseases ranging from neoplasms to viral infection. However, its systemic use is restricted by its serious side effects and limited efficacy due to activation of T regulatory cells (Tregs). IL2 signaling is mediated through interactions with a multi-subunit receptor complex containing IL2Rα, IL2Rβ and IL2Rγ...
September 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28916608/gait-speed-assessment-in-transcatheter-aortic-valve-replacement-a-step-in-the-right-direction
#2
EDITORIAL
Jonathan Afilalo, Daniel E Forman
No abstract text is available yet for this article.
September 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28899988/impact-of-incident-heart-failure-on-body-composition-over-time-in-the-health-aging-and-body-composition-study-population
#3
Daniel E Forman, Adam J Santanasto, Robert Boudreau, Tamara Harris, Alka M Kanaya, Suzanne Satterfield, Eleanor M Simonsick, Javed Butler, Jorge R Kizer, Anne B Newman
BACKGROUND: Prevalence of heart failure (HF) increases significantly with age, coinciding with age-related changes in body composition that are common and consequential. Still, body composition is rarely factored in routine HF care. METHODS AND RESULTS: The Health, Aging, and Body Composition study is a prospective cohort study of nondisabled adults. Using yearly dual-energy x-ray absorptiometry, body composition was assessed in the Health, Aging, and Body Composition study over 6 years, comparing those who developed incident HF versus those who did not...
September 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28895016/the-association-between-previous-success-with-weight-loss-through-dietary-change-and-success-in-a-lifestyle-modification-program
#4
Stephanie G Kerrigan, Margaret Clark, Alexandra Convertino, Evan M Forman, Meghan L Butryn
Prior work has yielded mixed results regarding the association between previous weight loss and success in a current weight loss attempt. The present study evaluated differences in baseline psychosocial processes, changes in these over time, and weight loss during a yearlong behavioral weight loss program between individuals who have and have not previously been successful losing weight through self-regulating dietary intake. Individuals with prior success had greater weight losses over time than those without...
September 11, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28894006/structural-and-hydrodynamic-properties-of-an-intrinsically-disordered-region-of-a-germ-cell-specific-protein-on-phase-separation
#5
Jacob P Brady, Patrick J Farber, Ashok Sekhar, Yi-Hsuan Lin, Rui Huang, Alaji Bah, Timothy J Nott, Hue Sun Chan, Andrew J Baldwin, Julie D Forman-Kay, Lewis E Kay
Membrane encapsulation is frequently used by the cell to sequester biomolecules and compartmentalize their function. Cells also concentrate molecules into phase-separated protein or protein/nucleic acid "membraneless organelles" that regulate a host of biochemical processes. Here, we use solution NMR spectroscopy to study phase-separated droplets formed from the intrinsically disordered N-terminal 236 residues of the germ-granule protein Ddx4. We show that the protein within the concentrated phase of phase-separated Ddx4, [Formula: see text], diffuses as a particle of 600-nm hydrodynamic radius dissolved in water...
September 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28885933/a-qualitative-study-of-participation-in-cardiac-rehabilitation-programs-in-an-integrated-health-care-system
#6
Nathalie McIntosh, Gemmae M Fix, Kelly Allsup, Martin Charns, Sarah McDannold, Kenneth Manning, Daniel E Forman
INTRODUCTION: Despite strong incentives to use cardiac rehabilitation (CR), patient participation is low in the Veterans Health Administration (VHA). This is paradoxical given that VHA is an integrated health care system that offers a range of CR programs which should logically reduce barriers to access to CR participation. The purpose of this study was to better understand the contextual factors that influence patient participation in CR and how patients consider factors together when making decisions about CR participation...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28882882/how-i-treat-patients-with-hiv-related-hematological-malignancies-using-hematopoietic-cell-transplantation
#7
Joseph C Alvarnas, John A Zaia, Stephen J Forman
Hematopoietic cell transplantation (HCT) has now been shown to be safe and effective for selected HIV-infected patients with hematological malignancies. Autologous HCT is now standard of care for patients with HIV-related lymphomas who otherwise meet standard transplant criteria. Limited data also supports use of allogeneic HCT (alloHCT) in selected HIV-infected patients who meet standard transplant criteria. We recommend enrolling patients on clinical trials that offer access to CCR5Δ32 homozygous donors, if available...
September 7, 2017: Blood
https://www.readbyqxmd.com/read/28874445/ifn-%C3%AE-mediates-experimental-cerebral-malaria-by-signalling-within-both-the-hematopoietic-and-non-hematopoietic-compartments
#8
Ana Villegas-Mendez, Patrick Strangward, Tovah N Shaw, Ivana Rajkovic, Vinko Tosevski, Ruth Forman, Werner Muller, Kevin N Couper
Experimental cerebral malaria (ECM) is an IFN-γ dependent syndrome. However, whether IFN-γ promotes ECM through direct and synergistic targeting of multiple cell populations or whether it causes ECM through acting primarily on a specific responsive cell type, is currently unknown. Here, using a panel of cell and compartment-specific IFN- γR2 deficient mice, we show that IFN-γ causes ECM by signalling within both the hematopoietic and non-haematopoietic compartments. Mechanistically, hematopoietic and non-haematopoietic compartment-specific IFN-γR signalling exerts additive effects in orchestrating intracerebral inflammation leading to ECM development...
September 5, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28866450/cftr-structure
#9
Isabelle Callebaut, P Andrew Chong, Julie D Forman-Kay
Structural studies of the cystic fibrosis transmembrane conductance regulator (CFTR) protein are critical to understand molecular mechanisms involved in gating of the apical anion channel as well as the way in which the gating is regulated, especially by the regulatory region (R region). They are also instrumental for understanding the root cause of cystic fibrosis (CF) and supporting the development of therapeutic strategies. In this short review, we summarize recent progress in the knowledge of the CFTR 3D structure and briefly discuss implications for CF drug development...
August 30, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28865495/repetitive-transcranial-magnetic-stimulation-rtms-for-treatment-resistant-major-depression-trmd-veteran-patients-study-protocol-for-a-randomized-controlled-trial
#10
Zhibao Mi, Kousick Biswas, J Kaci Fairchild, Anne Davis-Karim, Ciaran S Phibbs, Steven D Forman, Michael Thase, Gerald Georgette, Tamara Beale, David Pittman, Margaret Windy McNerney, Allyson Rosen, Grant D Huang, Mark George, Art Noda, Jerome A Yesavage
BACKGROUND: Evaluation of repetitive transcranial magnetic stimulation (rTMS) for treatment-resistant major depression (TRMD) in Veterans offers unique clinical trial challenges. Here we describe a randomized, double-blinded, intent-to-treat, two-arm, superiority parallel design, a multicenter study funded by the Cooperative Studies Program (CSP No. 556) of the US Department of Veterans Affairs. METHODS: We recruited medical providers with clinical expertise in treating TRMD at nine Veterans Affairs (VA) medical centers as the trial local investigators...
September 2, 2017: Trials
https://www.readbyqxmd.com/read/28864448/discussion-and-documentation-of-future-care-a-before-and-after-study-examining-the-impact-of-an-alternative-approach-to-recording-treatment-decisions-on-advance-care-planning-in-an-acute-hospital
#11
Alexandra C Malyon, Julia R Forman, Jonathan P Fuld, Zoë Fritz
OBJECTIVE: To determine whether discussion and documentation of decisions about future care was improved following the introduction of a new approach to recording treatment decisions: the Universal Form of Treatment Options (UFTO). METHODS: Retrospective review of the medical records of patients who died within 90 days of admission to oncology or respiratory medicine wards over two 3-month periods, preimplementation and postimplementation of the UFTO. A sample size of 70 per group was required to provide 80% power to observe a change from 15% to 35% in discussion or documentation of advance care planning (ACP), using a two-sided test at the 5% significance level...
September 1, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28863937/maternal-endometriosis-and-genital-malformations-in-boys-a-danish-register-based-study
#12
Linn Håkonsen Arendt, Morten Søndergaard Lindhard, Tine Brink Henriksen, Axel Forman, Jørn Olsen, Cecilia Høst Ramlau-Hansen
OBJECTIVE: To investigate the association between maternal endometriosis and occurrence of the genital anomalies cryptorchidism and hypospadias in sons. DESIGN: Population-based cohort study. SETTING: Not applicable. PATIENT(S): All live-born singleton boys born from 1978 to 2012. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Cryptorchidism and hypospadias in boys based on information from the Danish National Patient Register...
August 29, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28863281/aging-related-decline-in-the-induction-of-nrf2-regulated-antioxidant-genes-in-human-bronchial-epithelial-cells
#13
Lulu Zhou, Hongqiao Zhang, Kelvin J A Davies, Henry Jay Forman
Evidence from animal studies suggests that stress-induced increases in Nrf2-regulated antioxidant gene expression, a critical mechanism of cellular protection, declines with aging. This study examined whether this also occurs in humans. We measured the basal and inducible levels of Nrf2-regulated antioxidant genes in human bronchial epithelial (HBE) cells from subjects of young adult (21-29 years) and older (60-69 years) non-smokers, and explored factors affecting expresion. The basal expression of three representative Nrf2-regulated genes, the catalytic and modulator subunits of glutamate cysteine ligase (GCLC and GCLM, respectively), and NAD(P)H quinone oxidoreductase 1 (NQO1), was higher in cells from the older donors compared with cells from the young adult donors...
August 24, 2017: Redox Biology
https://www.readbyqxmd.com/read/28856946/spontaneous-hit-syndrome-post-knee-replacement-surgery-with-delayed-recovery-of-thrombocytopenia-a-case-report-and-literature-review
#14
Dilli Ram Poudel, Sushil Ghimire, Rashmi Dhital, Daniel A Forman, Theodore E Warkentin
Recently published reports have established a heparin-induced thrombocytopenia (HIT)-mimicking thromboembolic disorder without proximate heparin exposure, called spontaneous HIT syndrome. Although the pathophysiology remains unclear, anti-platelet factor 4 (PF4)/heparin antibodies possibly triggered by exposure to knee cartilage glycosaminoglycans or other non-heparin polyanions found on bacterial surfaces and nucleic acids have been postulated. We present a 53-year-old female receiving antithrombotic prophylaxis with aspirin following right total knee replacement surgery (without perioperative or any previous lifetime heparin exposure) who acutely presented with high-risk pulmonary embolism (PE) and right great saphenous vein thrombophlebitis on postoperative day (POD) 14; her platelet count at presentation was 13 × 10(9)/L...
September 2017: Platelets
https://www.readbyqxmd.com/read/28854723/bowel-endometriosis-syndrome-a-new-scoring-system-for-pelvic-organ-dysfunction-and-quality-of-life
#15
M Riiskjær, A G Egekvist, D Hartwell, A Forman, M Seyer-Hansen, U S Kesmodel
STUDY QUESTION: Is it possible to develop a validated score that can identify women with Bowel Endometriosis Syndrome (BENS) and be used to monitor the effect of medical and surgical treatment? SUMMARY ANSWER: The BENS score can be used to identify women with BENS and to monitor the effect of medical and surgical treatment of women suffering from bowel endometriosis. WHAT IS KNOWN ALREADY: Endometriosis is a heterogeneous disease with extensive variation in anatomical and clinical presentation, and symptoms do not always correspond to the disease burden...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28842397/lipocalins-are-required-for-apical-extracellular-matrix-organization-and-remodeling-in-caenorhabiditis-elegans
#16
Rachel Forman-Rubinsky, Jennifer D Cohen, Meera V Sundaram
A lipid and glycoprotein-rich apical extracellular matrix (aECM) or glycocalyx lines exposed membranes in the body, and is particularly important to protect narrow tube integrity. Lipocalins ("fat cups") are small, secreted, cup-shaped proteins that bind and transport lipophilic cargo and are often found in luminal or aECM compartments such as mammalian plasma, urine, or tear film. Although some lipocalins can bind known aECM lipids and/or matrix metalloproteinases, it is not known if and how lipocalins affect aECM structure due to challenges in visualizing the aECM in most systems...
August 25, 2017: Genetics
https://www.readbyqxmd.com/read/28841839/urokinase-type-plasminogen-activator-receptor-upar-tissue-factor-tf-and-epidermal-growth-factor-receptor-egfr-tumor-expression-patterns-and-prognostic-value-in-oral-cancer
#17
Anders Christensen, Katalin Kiss, Giedrius Lelkaitis, Karina Juhl, Morten Persson, Birgitte Wittenborg Charabi, Jann Mortensen, Julie Lyng Forman, Anne Lyngholm Sørensen, David Hebbelstrup Jensen, Andreas Kjaer, Christian von Buchwald
BACKGROUND: Tumor-specific biomarkers are a prerequisite for the development of targeted imaging and therapy in oral squamous cell carcinoma (OSCC). urokinase-type Plasminogen Activator Receptor (uPAR), Tissue Factor (TF) and Epidermal Growth Factor Receptor (EGFR) are three biomarkers that exhibit enhanced expression in many types of cancers, and have been investigated as potential biomarkers for targeted strategies and prognostication. The aim of the study was to investigate the expression patterns of uPAR, TF and EGFR and their potential prognostic value in OSCC...
August 25, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28837713/the-hereditary-paraganglioma-pheochromocytoma-syndrome-no-time-to-waste
#18
Michael J Hall, Andrea D Forman, Elias Obeid
No abstract text is available yet for this article.
August 24, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28826754/cost-effectiveness-of-magnetic-resonance-imaging-in-cervical-spine-clearance-of-neurologically-intact-patients-with-blunt-trauma
#19
Xiao Wu, Ajay Malhotra, Bertie Geng, Renu Liu, Khalid Abbed, Howard P Forman, Pina Sanelli
STUDY OBJECTIVE: Use of magnetic resonance imaging (MRI) for cervical clearance after a negative cervical computed tomography (CT) scan result in alert patients with blunt trauma who are neurologically intact is not infrequent, despite poor evidence in regard to its utility. The objective of this study is to evaluate the utility and cost-effectiveness of using MRI versus no follow-up in this patient population. METHODS: A modeling-based decision analysis was performed during the lifetime of a 40-year-old individual from a societal perspective...
August 18, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28815943/impact-response-comparison-between-parametric-human-models-and-postmortem-human-subjects-with-a-wide-range-of-obesity-levels
#20
Kai Zhang, Libo Cao, Yulong Wang, Eunjoo Hwang, Matthew P Reed, Jason Forman, Jingwen Hu
OBJECTIVE: Field data analyses have shown that obesity significantly increases the occupant injury risks in motor vehicle crashes, but the injury assessment tools for people with obesity are largely lacking. The objectives of this study were to use a mesh morphing method to rapidly generate parametric finite element models with a wide range of obesity levels and to evaluate their biofidelity against impact tests using postmortem human subjects (PMHS). METHODS: Frontal crash tests using three PMHS seated in a vehicle rear seat compartment with body mass index (BMI) from 24 to 40 kg/m(2) were selected...
August 17, 2017: Obesity
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