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https://www.readbyqxmd.com/read/29322201/characterization-of-corticospinal-activation-of-finger-motor-neurons-during-precision-and-power-grip-in-humans
#1
Christian Svane, Christian Riis Forman, Jens Bo Nielsen, Svend Sparre Geertsen
Direct and indirect corticospinal pathways to finger muscles may play a different role in control of the upper extremity. We used transcranial magnetic stimulation (TMS) and coherence analysis to characterize the corticospinal drive to the first dorsal interosseous (FDI) and abductor pollicis brevis (APB) when active during a precision and power grip task. In experiment 1, single motor units were recorded during precision grip and power grip in 20 adults (25.2 ± 7.1 years). Post-stimulus time histograms (PSTH) were obtained following TMS...
January 10, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29317130/navigating-the-complex-challenges-of-fertility-preservation
#2
EDITORIAL
Lisa C Grossman Becht, Eric J Forman
No abstract text is available yet for this article.
January 6, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29316016/non-invasive-measurement-of-reepithelialization-and-microvascularity-of-suction-blister-wounds-with-benchmarking-to-histology
#3
Heidi Fhaer Larsen, Malin Glindvad Ahlström, Lise Mette Rahbek Gjerdrum, Mette Mogensen, Khaled Ghathian, Henrik Calum, Anne Lyngholm Sørensen, Julie Lyng Forman, Mark Vandeven, Marian N Holerca, Laurence Du-Thumm, Lars Nannestad Jorgensen, Magnus S Ågren
We explored use of the suction-blister wound model in the assessment of not only epidermal regeneration but also pain, the microvascular response and bacteriology. The effects of topical zinc sulfate were studied to articulate the methodologies in this double-blind trial. One epidermal suction blister (10 mm) was induced on each buttock in 30 healthy volunteers (15 females:15 males) and de-roofed on day 0. The wounds were randomized to daily treatment with 1.4% zinc sulfate shower gel (n = 20), placebo (n = 20) or control (n = 20)...
January 8, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29303735/interferonopathies-in-laboratory-negative-suspected-congenital-infection
#4
Eva B Forman, Mary D King, Nicholas M Allen
No abstract text is available yet for this article.
January 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29298475/neuropelveology-an-emerging-discipline-for-the-management-of-chronic-pelvic-pain
#5
REVIEW
Marc Possover, Karl-Erik Andersson, Axel Forman
Chronic pelvic pain (CPP) is a common condition involving multiple, organ-specific medical specialties, each with its own approach to diagnosis and treatment. Management requires knowledge of the interplay between pelvic organ function and neuro-functional anatomy, and of the neurologic and psychological aspects of CPP, but no current specialty fully encompasses this approach. Neuropelveology is an emerging discipline focusing on pathologies of the pelvic nervous system on a cross-disciplinary basis. It involves a neurological/neurosurgical approach, combining the knowledge required for a proper neurologic diagnosis, confirmation by transvaginal/transrectal examination of the pelvic nerves, and advanced laparoscopic surgery in selected cases of CPP...
December 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/29298160/myeloablative-autologous-stem-cell-transplantation-for-severe-scleroderma
#6
Keith M Sullivan, Ellen A Goldmuntz, Lynette Keyes-Elstein, Peter A McSweeney, Ashley Pinckney, Beverly Welch, Maureen D Mayes, Richard A Nash, Leslie J Crofford, Barry Eggleston, Sharon Castina, Linda M Griffith, Julia S Goldstein, Dennis Wallace, Oana Craciunescu, Dinesh Khanna, Rodney J Folz, Jonathan Goldin, E William St Clair, James R Seibold, Kristine Phillips, Shin Mineishi, Robert W Simms, Karen Ballen, Mark H Wener, George E Georges, Shelly Heimfeld, Chitra Hosing, Stephen Forman, Suzanne Kafaja, Richard M Silver, Leroy Griffing, Jan Storek, Sharon LeClercq, Richard Brasington, Mary E Csuka, Christopher Bredeson, Carolyn Keever-Taylor, Robyn T Domsic, M Bashar Kahaleh, Thomas Medsger, Daniel E Furst
BACKGROUND: Despite current therapies, diffuse cutaneous systemic sclerosis (scleroderma) often has a devastating outcome. We compared myeloablative CD34+ selected autologous hematopoietic stem-cell transplantation with immunosuppression by means of 12 monthly infusions of cyclophosphamide in patients with scleroderma. METHODS: We randomly assigned adults (18 to 69 years of age) with severe scleroderma to undergo myeloablative autologous stem-cell transplantation (36 participants) or to receive cyclophosphamide (39 participants)...
January 4, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29290285/pre-radiation-dental-considerations-and-management-for-head-and-neck-cancer-patients
#7
REVIEW
Kenneth Kufta, Michael Forman, Samuel Swisher-McClure, Thomas P Sollecito, Neeraj Panchal
Treatment of head and neck cancer (HNC) is accompanied by a high rate of morbidity, and complications can have a lifelong, profound impact on both patients and caregivers. Radiation-related injury to the hard and soft tissue of the head and neck can significantly decrease patients' quality of life. The purpose of this study is to provide patent-specific guidelines for managing the oral health and related side effects of HNC patients treated with radiation therapy. Based on reviewed articles retrieved on the PubMed database, guidelines for management of the oral health of this patient population were organized into three separate categories: cancer, patient, and dentition...
January 2018: Oral Oncology
https://www.readbyqxmd.com/read/29289757/tandem-autologous-hematopoietic-cell-transplantation-for-patients-with-primary-progressive-or-recurrent-hodgkin-lymphoma-a-swog-and-blood-marrow-transplant-clinical-trials-network-phase-ii-trial-swog-s0410-bmt-ctn-0703
#8
Eileen P Smith, Hongli Li, Jonathan W Friedberg, Louis S Constine, Lisa M Rimsza, James R Cook, Ginna G Laport, Leslie L Popplewell, Leona A Holmberg, Sonali M Smith, Michael LeBlanc, Stephen J Forman, Richard I Fisher, Patrick J Stiff
Based on promising pilot data, a Phase II tandem autologous hematopoietic stem cell transplant (AHSCT) trial for relapsed/refractory Hodgkin Lymphoma (HL) was performed in the US intergroup setting to determine if long-term progression-free survival (PFS) could be improved. Patients were enrolled after salvage therapy and stem cell collection. Sensitivity to salvage was defined by 1999 Standardized Response Criteria and did not include FDG-PET. Cycle 1 consisted of melphalan 150 mg/m2 with half of the stem cells...
December 28, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29275990/octogenarians-post-acute-care-use-after-cardiac-valve-surgery-and-recovery-clinical-implications
#9
Elizabeth Edmiston, Mary A Dolansky, Melissa Zullo, Daniel E Forman
Octogenarians receiving cardiac valve surgery is increasing and recovery is challenging. Post-acute care (PAC) services assist with recovery, yet services provided in facilities do not provide adequate cardiac-focused care or long-term self-management support. The purpose of the paper was to report post-acute care discharge rates in octogenarians and propose clinical implications to improve PAC services. Using a 2003 Medicare Part A database, we studied post-acute care service use in octogenarians after cardiac valve surgery...
December 21, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/29274893/cognitive-and-self-regulatory-mechanisms-of-obesity-study-cosmos-study-protocol-for-a-randomized-controlled-weight-loss-trial-examining-change-in-biomarkers-cognition-and-self-regulation-across-two-behavioral-treatments
#10
M A W Hawkins, Janna Colaizzi, John Gunstad, Joel W Hughes, Larry L Mullins, Nancy Betts, Caitlin E Smith, Natalie G Keirns, Kathleen D Vohs, Shirley M Moore, Evan Forman, William R Lovallo
Obesity is a global epidemic, yet successful interventions are rare. Up to 60% of people fail to achieve clinically meaningful, short-term weight loss (5-10% of start weight), whereas up to 72% are unsuccessful at achieving long-term weight loss (5-10% loss for ≥5years). Understanding how biological, cognitive, and self-regulatory factors work together to promote or to impede weight loss is clearly needed to optimize obesity treatment. This paper describes the methodology of the Cognitive and Self-regulatory Mechanisms of Obesity Study (the COSMOS trial)...
December 21, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29249822/phase-i-ii-trial-of-the-oral-regimen-ixazomib-pomalidomide-and-dexamethasone-in-relapsed-refractory-multiple-myeloma
#11
A Krishnan, P Kapoor, J M Palmer, N-C Tsai, S Kumar, S Lonial, M Htut, C Karanes, N Nathwani, M Rosenzweig, F Sahebi, G Somlo, L Duarte, J F Sanchez, D Auclair, S J Forman, J G Berdeja
In this phase I/II trial, a triplet regimen of ixazomib (Ixa: 3 or 4 mg), pomalidomide (Pom: 4 mg), and dexamethasone (Dex: 40 mg) was administered to 32 lenalidomide-refractory multiple myeloma (MM) patients; 31 were evaluable for response and toxicity. At dose level 1 (DL1, 3 mg Ixa), 1/3 patients experienced grade 3 fatigue, grade 3 lung infection, grade 4 neutropenia, and grade 4 thrombocytopenia; all were considered dose limiting. Per 3+3 phase I design, an additional 3 patients were enrolled to DL1, with no further dose limiting toxicity (DLT)...
December 18, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29235401/what-do-human-rights-bring-to-discussions-of-power-and-politics-in-health-policy-and-systems
#12
Lisa Forman
Scholarly interrogations of power and politics are not endemic to the disciplines primarily tasked with exploring health policy and planning in the domestic or global domains. Scholars in these domains have come late to investigating power, prompted in part by the growing focus in domestic and global health research on the intersections between governance, globalization and health inequities. Recent prominent reports in this area increasingly point to human rights as important norms capable of responding in part to power differentials that sustain and exacerbate health inequities...
December 13, 2017: Global Public Health
https://www.readbyqxmd.com/read/29225946/did-the-right-to-health-get-across-the-line-examining-the-united-nations-resolution-on-the-sustainable-development-goals
#13
REVIEW
Claire E Brolan, Vannarath Te, Nadia Floden, Peter S Hill, Lisa Forman
Since the new global health and development goal, Sustainable Development Goal (SDG) 3, and its nine targets and four means of implementation were introduced to the world through a United Nations (UN) General Assembly resolution in September 2015, right to health practitioners have queried whether this goal mirrors the content of the human right to health in international law. This study examines the text of the UN SDG resolution, Transforming our world: the 2030 Agenda for Sustainable Development, from a right to health minimalist and right to health maximalist analytic perspective...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29225164/efficacy-of-high-dose-therapy-and-autologous-hematopoietic-cell-transplantation-in-gray-zone-lymphoma-a-us-multicenter-collaborative-study
#14
Mohamed A Kharfan-Dabaja, Renju Raj, Liana Nikolaenko, Sairah Ahmed, Nishitha Reddy, Sunita Nathan, Mohamad Cherry, Najla El-Jurdi, Cynthia Obiozor, Timothy S Fenske, Joo Song, Tariq Muzzafar, Ernesto Ayala, Bipin Savani, Mohamad Khawandanah, Paolo F Caimi, Mehdi Hamadani, Stephen J Forman, Mohamad Hussaini, Marcos de Lima, Horatiu Olteanu, Bijal Shah, Julio C Chavez, Monzr Al Malki, Ambuj Kumar, Siddhartha Ganguly
High-dose therapy (HDT) and autologous hematopoietic cell transplantation (auto-HCT) has been anecdotally prescribed in gray zone lymphoma (GZL), showing encouraging efficacy. We conducted a multicenter retrospective study aimed to assess outcomes after auto-HCT in 32 patients with GZL treated at 9 transplant centers in the United States. Median age of patients at transplantation was 38 (18-70) years and the majority were male (n=21, 66%). Median number of lines of therapy prior to transplantation was 2 (1-4)...
December 7, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29225075/multivalent-interactions-with-fbw7-and-pin1-facilitate-recognition-of-c-jun-by-the-scffbw7-ubiquitin-ligase
#15
Veronika Csizmok, Meri Montecchio, Hong Lin, Mike Tyers, Maria Sunnerhagen, Julie D Forman-Kay
Many regulatory proteins, including the transcription factor c-Jun, are highly enriched in disordered protein regions that govern growth, division, survival, differentiation, and response to signals. The stability of c-Jun is controlled by poorly understood regulatory interactions of its disordered region with both the E3 ubiquitin ligase SCFFbw7 and prolyl cis-trans isomerase Pin1. We use nuclear magnetic resonance and fluorescence studies of c-Jun to demonstrate that multisite c-Jun phosphorylation is required for high-affinity interaction with Fbw7...
November 27, 2017: Structure
https://www.readbyqxmd.com/read/29223747/an-automated-high-throughput-system-for-phenotypic-screening-of-chemical-libraries-on-c-elegans-and-parasitic-nematodes
#16
Frederick A Partridge, Anwen E Brown, Steven D Buckingham, Nicky J Willis, Graham M Wynne, Ruth Forman, Kathryn J Else, Alison A Morrison, Jacqueline B Matthews, Angela J Russell, David A Lomas, David B Sattelle
Parasitic nematodes infect hundreds of millions of people and farmed livestock. Further, plant parasitic nematodes result in major crop damage. The pipeline of therapeutic compounds is limited and parasite resistance to the existing anthelmintic compounds is a global threat. We have developed an INVertebrate Automated Phenotyping Platform (INVAPP) for high-throughput, plate-based chemical screening, and an algorithm (Paragon) which allows screening for compounds that have an effect on motility and development of parasitic worms...
December 2, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29212513/cardiac-amyloidosis-is-prevalent-in-older-patients-with-aortic-stenosis-and-carries-worse-prognosis
#17
João L Cavalcante, Shasank Rijal, Islam Abdelkarim, Andrew D Althouse, Michael S Sharbaugh, Yaron Fridman, Prem Soman, Daniel E Forman, John T Schindler, Thomas G Gleason, Joon S Lee, Erik B Schelbert
BACKGROUND: Non-invasive cardiac imaging allows detection of cardiac amyloidosis (CA) in patients with aortic stenosis (AS). Our objective was to estimate the prevalence of clinically suspected CA in patients with moderate and severe AS referred for cardiovascular magnetic resonance (CMR) in age and gender categories, and assess associations between AS-CA and all-cause mortality. METHODS: We retrospectively identified consecutive AS patients defined by echocardiography referred for further CMR assessment of valvular, myocardial, and aortic disease...
December 7, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29210709/alphaxalone-binds-in-inner-transmembrane-%C3%AE-%C3%AE-interfaces-of-%C3%AE-1%C3%AE-3%C3%AE-2-%C3%AE-aminobutyric-acid-type-a-receptors
#18
Alexis M Ziemba, Andrea Szabo, David W Pierce, Marian Haburcak, Alex T Stern, Anahita Nourmahnad, Elizabeth S Halpin, Stuart A Forman
BACKGROUND: Neurosteroids like alphaxalone are potent anxiolytics, anticonvulsants, amnestics, and sedative-hypnotics, with effects linked to enhancement of γ-aminobutyric acid type A (GABAA) receptor gating in the central nervous system. Data locating neurosteroid binding sites on synaptic αβγ GABAA receptors are sparse and inconsistent. Some evidence points to outer transmembrane β-α interfacial pockets, near sites that bind the anesthetics etomidate and propofol. Other evidence suggests that steroids bind more intracellularly in β-α interfaces...
November 28, 2017: Anesthesiology
https://www.readbyqxmd.com/read/29209856/accelerated-whole-brain-intracranial-vessel-wall-imaging-using-black-blood-fast-spin-echo-with-compressed-sensing-cs-space
#19
Chengcheng Zhu, Bing Tian, Luguang Chen, Laura Eisenmenger, Esther Raithel, Christoph Forman, Sinyeob Ahn, Gerhard Laub, Qi Liu, Jianping Lu, Jing Liu, Christopher Hess, David Saloner
OBJECTIVE: Develop and optimize an accelerated, high-resolution (0.5 mm isotropic) 3D black blood MRI technique to reduce scan time for whole-brain intracranial vessel wall imaging. MATERIALS AND METHODS: A 3D accelerated T1-weighted fast-spin-echo prototype sequence using compressed sensing (CS-SPACE) was developed at 3T. Both the acquisition [echo train length (ETL), under-sampling factor] and reconstruction parameters (regularization parameter, number of iterations) were first optimized in 5 healthy volunteers...
December 5, 2017: Magma
https://www.readbyqxmd.com/read/29197676/intravenous-busulfan-compared-to-total-body-irradiation-pre-transplant-conditioning-for-adults-with-acute-lymphoblastic-leukemia
#20
Partow Kebriaei, Claudio Anasetti, Mei-Jie Zhang, Hai-Lin Wang, Ibrahim Aldoss, Marcos de Lima, H Jean Khoury, Brenda M Sandmaier, Mary M Horowitz, Andrew Artz, Nelli Bejanyan, Stefan Ciurea, Hillard M Lazarus, Robert Peter Gale, Mark Litzow, Christopher Bredeson, Matthew D Seftel, Michael A Pulsipher, Jaap-Jan Boelens, Joseph Alvarnas, Richard Champlin, Stephen Forman, Vinod Pullarkat, Daniel Weisdorf, David I Marks
Total body irradiation (TBI) has been included in standard conditioning for acute lymphoblastic leukemia (ALL) before hematopoietic cell transplantation (HCT). Non-TBI regimens have incorporated busulfan (BU) to decrease toxicity. This retrospective study analyzed TBI and BU on outcomes of ALL patients aged 18-60 years, in first or second complete remission (CR), undergoing HLA-compatible sibling, related or unrelated donor HCT, reported to the Center for International Blood and Marrow Transplant Research from 2005 to 2014...
November 29, 2017: Biology of Blood and Marrow Transplantation
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