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https://www.readbyqxmd.com/read/29159405/management-of-tiny-unruptured-intracranial-aneurysms-a-comparative-effectiveness-analysis
#1
Ajay Malhotra, Xiao Wu, Howard P Forman, Charles C Matouk, Dheeraj Gandhi, Pina Sanelli
Importance: Unruptured intracranial aneurysms (UIAs) are relatively common in the general population and are being increasingly diagnosed; a significant proportion are tiny (≤3 mm) aneurysms. There is significant heterogeneity in practice and lack of clear guidelines on the management of incidental, tiny UIAs. It is important to quantify the implications of different management strategies in terms of health benefits to patients. Objective: To evaluate the effectiveness of routine treatment (aneurysm coiling) vs 3 strategies for imaging surveillance compared with no preventive treatment or routine follow-up of tiny UIAs...
November 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29119317/prodigiosin-violacein-and-volatile-organic-compounds-produced-by-widespread-cutaneous-bacteria-of-amphibians-can-inhibit-two-batrachochytrium-fungal-pathogens
#2
Douglas C Woodhams, Brandon C LaBumbard, Kelly L Barnhart, Matthew H Becker, Molly C Bletz, Laura A Escobar, Sandra V Flechas, Megan E Forman, Anthony A Iannetta, Maureen D Joyce, Falitiana Rabemananjara, Brian Gratwicke, Miguel Vences, Kevin P C Minbiole
Symbiotic bacteria can produce secondary metabolites and volatile compounds that contribute to amphibian skin defense. Some of these symbionts have been used as probiotics to treat or prevent the emerging disease chytridiomycosis. We examined 20 amphibian cutaneous bacteria for the production of prodigiosin or violacein, brightly colored defense compounds that pigment the bacteria and have characteristic spectroscopic properties making them readily detectable, and evaluated the antifungal activity of these compounds...
November 9, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/29112235/prevalence-of-anthracycline-related-cardiac-dysfunction-in-long-term-survivors-of-adult-onset-lymphoma
#3
Saro H Armenian, Luc Mertens, Cameron Slorach, Kalyanasundaram Venkataraman, Kristen Mascarenhas, Nitya Nathwani, F Lennie Wong, Stephen J Forman, Smita Bhatia
BACKGROUND: Anthracycline-related heart failure is a leading cause of morbidity in survivors of adult-onset lymphoma. There is a paucity of information on screening for late-occurring preclinical disease, which, in turn, has limited guidelines for early detection and intervention. The objectives of this study were to examine the prevalence and risk of cardiac dysfunction, as measured by echocardiography (abnormal left ventricular systolic/diastolic function or strain), in lymphoma survivors who received treatment with anthracyclines and to evaluate the diagnostic yield of blood biomarkers in the asymptomatic setting...
November 7, 2017: Cancer
https://www.readbyqxmd.com/read/29103912/optimization-of-il13r%C3%AE-2-targeted-chimeric-antigen-receptor-t-cells-for-improved-anti-tumor-efficacy-against-glioblastoma
#4
Christine E Brown, Brenda Aguilar, Renate Starr, Xin Yang, Wen-Chung Chang, Lihong Weng, Brenda Chang, Aniee Sarkissian, Alfonso Brito, James F Sanchez, Julie R Ostberg, Massimo D'Apuzzo, Behnam Badie, Michael E Barish, Stephen J Forman
T cell immunotherapy is emerging as a powerful strategy to treat cancer and may improve outcomes for patients with glioblastoma (GBM). We have developed a chimeric antigen receptor (CAR) T cell immunotherapy targeting IL-13 receptor α2 (IL13Rα2) for the treatment of GBM. Here, we describe the optimization of IL13Rα2-targeted CAR T cells, including the design of a 4-1BB (CD137) co-stimulatory CAR (IL13BBζ) and a manufacturing platform using enriched central memory T cells. Utilizing orthotopic human GBM models with patient-derived tumor sphere lines in NSG mice, we found that IL13BBζ-CAR T cells improved anti-tumor activity and T cell persistence as compared to first-generation IL13ζ-CAR CD8(+) T cells that had shown evidence for bioactivity in patients...
October 5, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29103338/reactions-to-symptoms-of-mental-disorder-and-help-seeking-in-sabah-malaysia
#5
Wendy Diana Shoesmith, Awang Faisal Bin Awang Borhanuddin, Pauline Yong Pau Lin, Ahmad Faris Abdullah, Norhayati Nordin, Beena Giridharan, Dawn Forman, Sue Fyfe
BACKGROUND: A better understanding is needed about how people make decisions about help seeking. MATERIALS: Focus group and individual interviews with patients, carers, healthcare staff, religious authorities, traditional healers and community members. DISCUSSION: Four stages of help seeking were identified: (1) noticing symptoms and initial labelling, (2) collective decision-making, (3) spiritual diagnoses and treatment and (4) psychiatric diagnosis and treatment...
November 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/29102704/primary-sclerosing-cholangitis-is-not-rare-among-blacks-in-a-multi-center-north-american-consortium
#6
David Goldberg, Cynthia Levy, Kidist Yimam, Stuart Gordon, Lisa Forman, Elizabeth Verna, Lei Yu, Robert Rahimi, Kathleen Schwarz, Bertus Eksteen, Daniel Pratt, Thomas Boyer, David Assis, Christopher Bowlus
No abstract text is available yet for this article.
November 1, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29100108/complex-regulatory-mechanisms-mediated-by-the-interplay-of-multiple-post-translational-modifications
#7
REVIEW
Veronika Csizmok, Julie D Forman-Kay
Post-translational modifications (PTMs), which are found largely in intrinsically disordered protein regions (IDRs), regulate protein activity, stability and interactions with partners. They are therefore critical for controlling essentially all cellular processes. A single modification event can have dramatic effects; however, proteins are often modified on multiple sites to collectively modulate the biological outcome. Multiple PTMs can mediate the same, complementary or opposing effects and the result of their interplay is determined by a complex combination of the number, positioning and type of modifications...
November 5, 2017: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/29089342/prognostic-value-of-cardiopulmonary-exercise-testing-in-heart-failure-with-reduced-midrange-and-preserved-ejection-fraction
#8
Wilson Nadruz, Erin West, Morten Sengeløv, Mário Santos, John D Groarke, Daniel E Forman, Brian Claggett, Hicham Skali, Amil M Shah
BACKGROUND: This study aimed to compare the independent and incremental prognostic value of peak oxygen consumption (VO2) and minute ventilation/carbon dioxide production (VE/VCO2) in heart failure (HF) with preserved (HFpEF), midrange (HFmEF), and reduced (HFrEF) ejection fraction (LVEF). METHODS AND RESULTS: In 195 HFpEF (LVEF ≥50%), 144 HFmEF (LVEF 40-49%), and 630 HFrEF (LVEF <40%) patients, we assessed the association of cardiopulmonary exercise testing variables with the composite outcome of death, left ventricular assist device implantation, or heart transplantation (256 events; median follow-up of 4...
October 31, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29080367/risk-of-bowel-obstruction-during-ivf-treatment-of-patients-with-deep-infiltrating-endometriosis
#9
Mikkel Seyer-Hansen, Anne Egekvist, Axel Forman, Mads Riiskjaer
INTRODUCTION: Women with endometriosis often experience pain and infertility. Medical treatment interferes with the possibility to attain pregnancy. For infertile women with endometriosis surgery is a possible treatment, but with advanced disease there is an increased risk of serious complications. With only limited pain, the women will often be referred for in vitro fertilization (IVF) treatment instead. The disease is estrogen dependant and during IVF treatment the women could theoretically experience worsening of their symptoms...
October 28, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29068844/response-to-letter-to-the-editor
#10
Rosha Forman, Christina Yarrington
No abstract text is available yet for this article.
October 2017: Journal of Perinatal & Neonatal Nursing
https://www.readbyqxmd.com/read/29067320/multiple-comorbid-neuropathologies-in-the-setting-of-alzheimer-s-disease-neuropathology-and-implications-for-drug-development
#11
REVIEW
Gil D Rabinovici, Maria C Carrillo, Mark Forman, Susan DeSanti, David S Miller, Nicholas Kozauer, Ronald C Petersen, Christopher Randolph, David S Knopman, Eric E Smith, Maria Isaac, Niklas Mattsson, Lisa J Bain, James A Hendrix, John R Sims
Dementia is often characterized as being caused by one of several major diseases, such as Alzheimer's disease (AD), cerebrovascular disease, Lewy body disease, or a frontotemporal degeneration. Failure to acknowledge that more than one entity may be present precludes attempts to understand interactive relationships. The clinicopathological studies of dementia demonstrate that multiple pathologic processes often coexist. How overlapping pathologic findings affect the diagnosis and treatment of clinical AD and other dementia phenotypes was the topic taken up by the Alzheimer's Association's Research Roundtable in October 2014...
January 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29061641/regional-delivery-of-chimeric-antigen-receptor-engineered-t-cells-effectively-targets-her2-breast-cancer-metastasis-to-the-brain
#12
Saul J Priceman, Dileshni Tilakawardane, Brook Jeang, John P Murad, Anthony K Park, Wen-Chung Chang, Julie R Ostberg, Josh Neman, Rahul Jandial, Jana Portnow, Stephen J Forman, Christine E Brown
PURPOSE: Metastasis to the brain from breast cancer remains a significant clinical challenge, and may be targeted with CAR-based immunotherapy. CAR design optimization for solid tumors is crucial due to the absence of truly restricted antigen expression and potential safety concerns with "on-target off-tumor" activity. Here, we have optimized HER2-CAR T cells for the treatment of breast to brain metastases, and determined optimal second generation CAR design and route of administration for xenograft mouse models of breast metastatic brain tumors, including multifocal and leptomeningeal disease...
October 23, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29061640/lenalidomide-enhances-the-function-of-cs1-chimeric-antigen-receptor-redirected-t-cells-against-multiple-myeloma
#13
Xiuli Wang, Miriam Walter, Ryan Urak, Lihong Weng, Christian Huynh, Laura Lim, ChingLam W Wong, Wen-Chung Chang, Sandra H Thomas, James Sanchez, Lu Yang, Christine E Brown, Flavia Pichiorri, Myo Htut, Amrita Y Krishnan, Stephen J Forman
PURPOSE: Multiple myeloma (MM) remains an incurable malignancy of plasma cells despite considerable advances in treatment. The purpose of the study was to develop novel CARs for the treatment of MM and explore combinatorial therapy using CAR T cells and immunomodulatory drugs such as lenalidomide for increasing treatment efficacy. EXPERIMENTAL DESIGN: We redirected central memory T cells to express second-generation CAR specific for CS1 and adoptively transferred them into MM tumor-bearing mice to test their anti-MM activity...
October 23, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29061141/a-multi-stakeholder-evaluation-of-the-baltimore-city-virtual-supermarket-program
#14
Pooja Lagisetty, Laura Flamm, Summer Rak, Jessica Landgraf, Michele Heisler, Jane Forman
BACKGROUND: Increasing access to healthy foods and beverages in disadvantaged communities is a public health priority due to alarmingly high rates of obesity. The Virtual Supermarket Program (VSP) is a Baltimore City Health Department program that uses online grocery ordering to deliver food to low-income neighborhoods. This study evaluates stakeholder preferences and barriers of program implementation. METHODS: This study assessed the feasibility, sustainability and efficacy of the VSP by surveying 93 customers and interviewing 14 programmatic stakeholders who had recently used the VSP or been involved with program design and implementation...
October 23, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29059269/the-practice-and-implications-of-finding-fluid-during-point-of-care-ultrasonography-a-review
#15
Rachel B Liu, Joseph H Donroe, Robert L McNamara, Howard P Forman, Chris L Moore
Importance: Point-of-care ultrasonography (POCUS) is an increasingly affordable and portable technology that is an important part of 21st-century medicine. When appropriately used, POCUS has the potential to expedite diagnosis and improve procedural success and safety. POCUS is now being adopted in medical education as early as the first year of medical school. While potentially powerful and versatile, POCUS is a user-dependent technology that has not been formalized or standardized yet within internal medicine residency training programs...
October 23, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29046900/us-intergroup-study-of-chemotherapy-plus-dasatinib-and-allogeneic-stem-cell-transplant-in-philadelphia-chromosome-positive-all
#16
Farhad Ravandi, Megan Othus, Susan M O'Brien, Stephen J Forman, Chul S Ha, Jeffrey Y C Wong, Martin S Tallman, Elisabeth Paietta, Janis Racevskis, Geoffrey L Uy, Mary Horowitz, Naoko Takebe, Richard Little, Uma Borate, Partow Kebriaei, Laura Kingsbury, Hagop M Kantarjian, Jerald P Radich, Harry P Erba, Frederick R Appelbaum
This multicenter trial was conducted to determine whether the addition of dasatinib to chemotherapy followed by an allogeneic hematopoietic cell transplant (HCT) in patients with Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL) was feasible. Patients ≥ 18 and ≤ 60 years of age with newly diagnosed Ph+ ALL received up to 8 cycles of alternating hyperCVAD and high dose cytarabine and methotrexate with dasatinib. Patients with an available matched sibling or unrelated donor underwent an allogeneic HCT in first complete remission (CR1) followed by daily dasatinib starting from day 100...
December 27, 2016: Blood Advances
https://www.readbyqxmd.com/read/29043057/flower-resource-and-land-management-drives-hoverfly-communities-and-bee-abundance-in-seminatural-and-agricultural-grasslands
#17
Andrew Lucas, James C Bull, Natasha de Vere, Penelope J Neyland, Dan W Forman
Pollination is a key ecosystem service, and appropriate management, particularly in agricultural systems, is essential to maintain a diversity of pollinator guilds. However, management recommendations frequently focus on maintaining plant communities, with the assumption that associated invertebrate populations will be sustained. We tested whether plant community, flower resources, and soil moisture would influence hoverfly (Syrphidae) abundance and species richness in floristically-rich seminatural and floristically impoverished agricultural grassland communities in Wales (U...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29042531/extrafollicular-cd4-t-b-interactions-are-sufficient-for-inducing-autoimmune-like-chronic-graft-versus-host-disease
#18
Ruishu Deng, Christian Hurtz, Qingxiao Song, Chanyu Yue, Gang Xiao, Hua Yu, Xiwei Wu, Markus Muschen, Stephen Forman, Paul J Martin, Defu Zeng
Chronic graft-versus-host disease (cGVHD) is an autoimmune-like syndrome mediated by pathogenic CD4(+) T and B cells, but the function of extrafollicular and germinal center CD4(+) T and B interactions in cGVHD pathogenesis remains largely unknown. Here we show that extrafollicular CD4(+) T and B interactions are sufficient for inducing cGVHD, while germinal center formation is dispensable. The pathogenesis of cGVHD is associated with the expansion of extrafollicular CD44(hi)CD62(lo)PSGL-1(lo)CD4(+) (PSGL-1(lo)CD4(+)) T cells...
October 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29021218/transcriptomic-analysis-of-octanoic-acid-response-in-drosophila-sechellia%C3%A2-using-rna-sequencing
#19
Stephen M Lanno, Sara M Gregory, Serena J Shimshak, Maximilian K Alverson, Kenneth Chiu, Arden L Feil, Morgan G Findley, Taylor E Forman, Julia T Gordon, Josephine Ho, Joanna L Krupp, Ivy Lam, Josh Lane, Samuel C Linde, Ashley E Morse, Serena Rusk, Robie Ryan, Avva Saniee, Ruchi B Sheth, Jennifer J Siranosian, Lalitpatr Sirichantaropart, Sonya R Sternlieb, Christina M Zaccardi, Joseph D Coolon
The dietary specialist fruit fly Drosophila sechellia has evolved to specialize on the toxic fruit of its host plant Morinda citrifolia Toxicity of Morinda fruit is primarily due to high levels of octanoic acid (OA). Using RNA interference (RNAi), prior work found that knockdown of Osiris family genes Osiris 6 (Osi6), Osi7, and Osi8 led to increased susceptibility to OA in adult D. melanogaster flies, likely representing genes underlying a Quantitative Trait Locus (QTL) for OA resistance in D. sechellia While genes in this major effect locus are beginning to be revealed, prior work has shown at least five regions of the genome contribute to OA resistance...
October 12, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29017909/objectively-measuring-effects-of-electro-acupuncture-in-parkinsonian-rhesus-monkeys
#20
Rui Zhang, Anders H Andersen, Peter A Hardy, Eric Forman, April Evans, Yi Ai, Jin Yue, Guihua Yue, Don M Gash, Richard Grondin, Zhiming Zhang
Acupuncture has increasingly been used as an alternative therapy for treatment of Parkinson's disease (PD). However, the efficacy of acupunture for PD still remains unclear. The present study was designed to objectively and safely monitor anti-parkinsonian effects of electroacupuncture (EA) and brain activity in nonhuman primates modeling human PD. Six middle-aged rhesus monkeys were extensively studied by a computerized behavioral testing battery and by pharmacological MRI (phMRI) scans with specific dopaminergic drug stimulations...
October 7, 2017: Brain Research
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