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https://www.readbyqxmd.com/read/29766272/blood-pressure-is-normal-but-is-the-heart
#1
Serkan Fazlı Çelik, Cemşit Karakurt, Yılmaz Tabel, Taner Elmas, Saim Yoloğlu
BACKGROUND: There is no detailed strain analysis of cardiac functions in treated hypertensive pediatric patients. The aim of this study was to evaluate the cardio-protective effects of different drug classes in treated pediatric hypertensive patients. METHODS: Sixty non-obese-treated hypertensive patients with preserved left ventricular (LV) systolic function and 45 age-, sex-, and body mass index-matched healthy subjects underwent clinical evaluation, including 24-h ambulatory blood pressure monitoring, standard echocardiographic examination, tissue Doppler imaging, and two-dimensional Speckle Tracking Echocardiography...
May 15, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29669232/relationship-between-clinic-and-ambulatory-blood-pressure-measurements-and-mortality
#2
MULTICENTER STUDY
José R Banegas, Luis M Ruilope, Alejandro de la Sierra, Ernest Vinyoles, Manuel Gorostidi, Juan J de la Cruz, Gema Ruiz-Hurtado, Julián Segura, Fernando Rodríguez-Artalejo, Bryan Williams
BACKGROUND: Evidence for the influence of ambulatory blood pressure on prognosis derives mainly from population-based studies and a few relatively small clinical investigations. This study examined the associations of blood pressure measured in the clinic (clinic blood pressure) and 24-hour ambulatory blood pressure with all-cause and cardiovascular mortality in a large cohort of patients in primary care. METHODS: We analyzed data from a registry-based, multicenter, national cohort that included 63,910 adults recruited from 2004 through 2014 in Spain...
April 19, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29622755/effects-of-pharmacological-reversal-of-hyperuricemia-on-features-of-the-metabolic-syndrome-in-patients-with-gouty-arthritis
#3
Mariana Marin, Naim M Maalouf
Hyperuricemia has been associated in epidemiological studies with the development of obesity, hypertension, insulin resistance and type 2 diabetes. Nevertheless, it remains unclear whether lowering of serum uric acid (UA) alters any of the features of the metabolic syndrome. In this prospective study (ClinicalTrials.gov identifier: NCT01654276), 24 patients with gouty arthritis and hyperuricemia were treated for 6 months with the xanthine oxidase inhibitor febuxostat to lower serum UA to <6 mg/dL. Measurements of 24 hours ambulatory blood pressure (ABP) and serum and urine markers of the metabolic syndrome were measured at baseline and at the end of 6 months of febuxostat...
April 4, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29602408/an-update-on-hypertension-in-children-with-type-1-diabetes
#4
REVIEW
Mallory L Downie, Emma H Ulrich, Damien G Noone
The prevalence of hypertension in children with type 1 diabetes is reported to be between 6% and 16%. This potentially modifiable cardiovascular risk factor may go undiagnosed and undertreated, particularly in children with type 1 diabetes. Recent updated Canadian clinical practice guidelines recommend blood pressure screening every 2 years in children with type 1 diabetes as well as routine use of ambulatory blood pressure monitoring. Risk factors for hypertension in type 1 diabetes include poor glycemic control, overweight and obesity and genetic predisposition for hypertension...
April 2018: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29528260/prevalence-of-hypertension-determined-by-ambulatory-blood-pressure-monitoring-abpm-and-body-composition-in-long-term-survivors-of-childhood-cancer
#5
Elif Guler, Nilgun Col, Mithat Buyukcelik, Ayse Balat
AIM: In recent years, survival rates of childhood cancers have significantly increased, and occurrence of long-term adverse late effects (eg, insulin resistance, diabetes mellitus, metabolic syndrome, hypertension) has become increasingly important. Early diagnosis of obesity/hypertension in childhood is essential to avoid morbidity in the adulthood. Therefore, this study was aimed to determine the blood pressure (BP) profile by ambulatory BP monitoring (ABPM) method, and prevalence of hypertension, obesity, abdominal obesity among childhood cancer survivors...
February 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29471357/obese-hypertensive-men-have-lower-circulating-proatrial-natriuretic-peptide-concentrations-despite-greater-left-atrial-size
#6
Camilla L Asferg, Ulrik B Andersen, Allan Linneberg, Jens P Goetze, Jørgen L Jeppesen
BACKGROUND: Obese persons have lower circulating natriuretic peptide (NP) concentrations. It has been proposed that this natriuretic handicap plays a role in obesity-related hypertension. In contrast, hypertensive patients with left atrial enlargement have higher circulating NP concentrations. On this background, we investigated whether obese hypertensive men could have lower circulating NP concentrations despite evidence of pressure-induced greater left atrial size. METHODS: We examined 98 obese men (body mass index [BMI] ≥ 30...
May 7, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29466195/-nerve-growth-factor-in-patients-with-arterial-hypertension-neuropsychical-hemodynamic-metabolic-relationships
#7
A V Ushakov, V S Ivanchenko, A I Gordienko, N V Khimich, A A Gagarina
AIM: To investigate the changes of serum nerve growth factor (NGF) level in patients with arterial hypertension (AH) and obesity in dependence on the degree of psycho-emotional stress and physical activity. MATERIALS AND METHODS: We examined 76 male patients with stage I and II AH with mean age 46.75±0.56 years (36 patients with and 40 without obesity). Control group consisted of 26 individuals without AH, obesity, and cardiovascular diseases. All patients underwent ambulatory blood pressure (BP) monitoring...
February 2018: Kardiologiia
https://www.readbyqxmd.com/read/29465710/blood-pressure-variability-increases-with-advancing-chronic-kidney-disease-stage-a-cross-sectional-analysis-of-16-546-hypertensive-patients
#8
Pantelis A Sarafidis, Luis M Ruilope, Charalampos Loutradis, Manuel Gorostidi, Alejandro de la Sierra, Juan J de la Cruz, Ernest Vinyoles, Juan A Divisón-Garrote, Julián Segura, José R Banegas
OBJECTIVE: Increased BP-variability predicts cardiovascular morbidity and mortality in hypertensives. This study aimed to examine short-term BP-variability according to renal function stage. METHODS: We included 16 546 patients [10 270 (62.1%) without/6276 (38.9%) with CKD Stage 1-5] from the Spanish Ambulatory-Blood-Pressure Monitoring (ABPM) Registry. Stages of CKD were defined according to K/DIGO criteria, based on estimated glomerular filtration rate calculated with the CKD-EPI equation and albumin-to-creatine ratio...
May 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29443353/obesity-masks-the-relationship-between-dietary-salt-intake-and-blood-pressure-in-people-of-african-ancestry-the-impact-of-obesity-on-the-relationship-between-sodium-and-blood-pressure
#9
Muzi Maseko, Mercy Mashao, Abdulraheem Bawa-Allah, Edgar Phukubje, Bongubuhle Mlambo, Thamsanqa Nyundu
Previous studies conducted to investigate the relationship between sodium intake and blood pressure in our African population have yielded contradictory results. With the high prevalence of obesity in this population, it is possible that these contradictory findings are due to the masking effects of obesity on this relationship. We measured 24-hour ambulatory blood pressure and 24-hour urine excretion on 547 South Africans of African ancestry. A multivariate regression analysis revealed no independent relationship between 24-hour sodium excretion and blood pressure in the total population sample, but when participants were stratified according to body mass index (BMI) status, there was a significant association between 24-hour sodium excretion and blood pressure in the normal-BMI participants but not in the overweight/obese participants...
February 12, 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29426831/cardiovascular-risk-factors-and-subclinical-organ-damage-after-hematopoietic-stem-cell-transplantation-in-pediatric-age
#10
Bianca Borchert-Mörlins, Nima Memaran, Martin Sauer, Britta Maecker-Kolhoff, Karl-Walter Sykora, Ricarda Blöte, Elena Bauer, Bernhard M W Schmidt, Anette Melk, Rita Beier
Advances in allogeneic hematopoietic stem cell transplantation (HSCT) in malignant and non-malignant diseases result in more long-term survivors, in whom cardiovascular (CV) disease is one leading non-cancer cause of death. This study aimed to evaluate risk factors and subclinical CV organ damage in survivors after HSCT in pediatric age. We enrolled 64 children in a cross-sectional approach 3.3 ± 3.1 years after HSCT. Anthropometric data, laboratory values, office and 24-h ambulatory blood pressure monitoring (ABPM) were evaluated, showing a high prevalence of obesity, hypertension and dyslipidemia...
February 9, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29420079/increased-masked-hypertension-prevalence-in-patients-with-obesity
#11
Selçuk Özkan, Naim Ata, Bunyamin Yavuz
OBJECTIVES: Masked hypertension is associated with an increased risk for cardiovascular conditions. The aim of the study was to evaluate the relationship obesity parameters, including body weight, waist circumference, and body mass index. METHODS: The study group consisted of 251 consecutive outpatient subjects without overt hypertension. Subjects were classified according to BMI. After a complete medical history and laboratory examination, patients' height, weight, waist circumference heart rate, and office blood pressure were recorded...
February 8, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29373321/whole-blood-viscosity-and-cerebral-blood-flow-velocities-in-obese-hypertensive-or-obese-normotensive-adolescents
#12
Meltem Akcaboy, Bijen Nazliel, Tayfun Goktas, Serdar Kula, Bülent Celik, Necla Buyan
BACKGROUND: Obesity affects all major organ systems and leads to increased morbidity and mortality. Whole blood viscosity is an important independent regulator of cerebral blood flow. The aim of the present study was to evaluate the effect of whole blood viscosity on cerebral artery blood flow velocities using transcranial Doppler ultrasound in pediatric patients with obesity compared to healthy controls and analyze the effect of whole blood viscosity and blood pressure status to the cerebral artery blood flow velocities...
March 28, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29359025/cardiac-autonomic-neuropathy-risk-factors-diagnosis-and-treatment
#13
REVIEW
Victoria A Serhiyenko, Alexandr A Serhiyenko
Cardiac autonomic neuropathy (CAN) is a serious complication of diabetes mellitus (DM) that is strongly associated with approximately five-fold increased risk of cardiovascular mortality. CAN manifests in a spectrum of things, ranging from resting tachycardia and fixed heart rate (HR) to development of "silent" myocardial infarction. Clinical correlates or risk markers for CAN are age, DM duration, glycemic control, hypertension, and dyslipidemia (DLP), development of other microvascular complications...
January 15, 2018: World Journal of Diabetes
https://www.readbyqxmd.com/read/29334265/prevalence-and-covariates-of-uncontrolled-hypertension-in-ischemic-stroke-survivors-the-norwegian-stroke-in-the-young-study
#14
Åshild Oftedal, Eva Gerdts, Ulrike Waje-Andreassen, Annette Fromm, Halvor Naess, Anja Linde, Sahrai Saeed
PURPOSE: Hypertension is the most important modifiable risk factor for stroke. Few data are available on control of hypertension in younger ischemic stroke survivors. MATERIAL AND METHODS: We assessed clinic and ambulatory blood pressure (BP) measurements in 320 patients aged 15-60 years (mean 48 ± 10) included in the Norwegian Stroke in the Young Study during 3-months follow-up after the index stroke. Controlled hypertension was defined as ambulatory BP <130/80 mmHg...
January 15, 2018: Blood Pressure
https://www.readbyqxmd.com/read/29332108/impact-of-body-mass-index-on-high-blood-pressure-among-obese-children-in-the-western-region-of-saudi-arabia
#15
Abdulmoein E Al-Agha, Areej O Mahjoub
To evaluate the impact of body mass index (BMI) on high blood pressure among obese children and adolescents in western region, Saudi Arabia.  Methods: Cross-sectional data were obtained from 306 (female: 140, male: 166) child, between August 2016 and March 2017. A questioner was filled by health professionals at ambulatory pediatric clinic followed by waist-hip circumference, height, weight, and blood pressure measurement. Diastolic blood pressure (DBP) and systolic blood pressure (SBP) were adjusted to gender, height, and age...
January 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29316855/the-role-of-noninvasive-cardiovascular-testing-applied-clinical-nutrition-and-nutritional-supplements-in-the-prevention-and-treatment-of-coronary-heart-disease
#16
Mark Houston
Numerous clinical trials suggest that we have reached a limit in our ability to decrease the incidence of coronary heart disease (CHD) and cardiovascular disease (CVD) utilizing the traditional diagnostic evaluation, prevention and treatment strategies for the top five cardiovascular risk factors of hypertension, diabetes mellitus, dyslipidemia, obesity and smoking. About 80% of heart disease (heart attacks, angina, coronary heart disease and congestive heart failure) can be prevented by optimal nutrition, optimal exercise, optimal weight and body composition, mild alcohol intake and avoiding smoking...
March 2018: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/29288728/the-rs243866-243865-polymorphisms-in-mmp-2-gene-and-the-relationship-with-bp-control-in-obese-resistant-hypertensive-subjects
#17
Alessandra M V Ritter, Ana Paula de Faria, Natália R Barbaro, Andréa R Sabbatini, Nathália Batista Corrêa, Veridiana Brunelli, Andre Fattori, Rivadavio Amorim, Rodrigo Modolo, Heitor Moreno
We sought to investigate whether the polymorphisms rs243865 (-1306C>T); rs243866 (-1575G>A) and rs2285053 (-735C>T) in metalloproteinases 2 - MMP-2 gene and rs17576 (Q279R), rs17577 (Q668R) and rs3918242 (-1562C>T) in MMP-9 gene are associated with clinical outcomes in obese resistant hypertensive (RH) subjects. One hundred and twenty RH were enrolled in this cross-sectional study and divided into obese (n=63) and non-obese (n=57) according to body mass index. Genotypes were determined by real-time PCR using TaqMan probes...
March 10, 2018: Gene
https://www.readbyqxmd.com/read/29240959/evaluation-of-left-ventricular-function-in-overweight-children-and-teenagers-with-arterial-hypertension-and-white-coat-hypertension
#18
Tomasz Florianczyk, Malgorzata Golabek-Dylewska, Beata Kucinska, Bozena Werner
BACKGROUND: Obesity in childhood is strongly associated with elevated arterial blood pressure and risk of hypertension. The aim of the study was the evaluation of left ventricular function in hypertensive and white coat hypertensive overweight children and teenagers. METHODS: The study group consisted of 74 overweight patients aged 10.3 ± 3.1 years (range: 6-16 years) diagnosed as hypertensive in standard blood pressure measurement. The control group consisted of 31 normotensive and normoweight children...
December 14, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/29200886/monitoring-and-management-of-hypertension-with-obesity-in-adolescents
#19
REVIEW
Bonita Falkner
Largely due to the childhood obesity epidemic, there has been an increase in the prevalence of hypertension in children and adolescents. Obesity associated hypertension is the most common hypertension phenotype among adolescents. Approximately 30% of obese adolescents have elevated blood pressure (BP) or hypertension. Updated definitions of elevated BP and hypertension in adolescents are now similar to definitions of BP status in adults. For adolescents ≥13 years of age, elevated BP is 120 to 129/<80 mm Hg...
2017: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/29192955/epidemiology-of-dyslipidaemia-in-professional-drivers-results-of-racer-abpm-risk-of-adverse-cardiovascular-events-among-professional-drivers-in-poland-ambulatory-blood-pressure-monitoring-study
#20
Bartosz Krzowski, Anna E Płatek, Filip M Szymański, Anna Ryś, Karolina Semczuk-Kaczmarek, Karolina Adamkiewicz, Marcin Kotkowski, Krzysztof J Filipiak
BACKGROUND: Professional drivers are a group exposed to many cardiovascular risk factors. Non-systematic working hours, prolonged stress, low physical activity, along with irregular, and in most cases, unhealthy meals are common aspects of the normal working schedule of most of the professional drivers. These translate into high risk of cardiovascular disease (CVD). AIM: The aim of the current analysis was to establish the prevalence of dyslipidaemia in a group of continuous professional drivers...
2018: Kardiologia Polska
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