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https://www.readbyqxmd.com/read/28337615/longer-duration-of-obesity-is-associated-with-a-reduction-in-urinary-angiotensinogen-in-prepubertal-children
#1
Manuela Morato, Liane Correia-Costa, Teresa Sousa, Dina Cosme, Franz Schaefer, José Carlos Areias, António Guerra, Alberto Caldas Afonso, Henrique Barros, Ana Azevedo, António Albino-Teixeira
BACKGROUND: We aimed to study the impact of obesity on urinary excretion of angiotensinogen (U-AGT) in prepubertal children, focusing on the duration of obesity and gender. Also, we aimed to evaluate whether plasma angiotensinogen (P-AGT) and hydrogen peroxide (H2O2) play a role in the putative association. METHODS: Cross-sectional evaluation of 305 children aged 8-9 years (160 normal weight, 86 overweight, and 59 obese). Anthropometric measurements and 24-h ambulatory blood pressure monitoring were performed...
March 23, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28290827/-azilsartan-medoxomil-capabilities-in-arterial-hypertension-and-obesity
#2
Y A Vasyuk, E Y Shupenina, V V Nesvetov, E A Nesterova, E I Golubkova
Arterial hypertension (AH) is one of the most common cardiovascular disease. Angiotensin II (AT II), the hormone of renin-angiotensin-aldosterone system, realizes its negative effects through AT 1 receptors - application point of angiotensin receptor blockers (ARB). Due to different dissociation AT 1 receptors properties some ARBs are more effective than others. Multiply multicenter randomized and observational studies approve the effectiveness and safety of azilsartan medoxomil in patients with AH 1-2 grade...
December 2016: Kardiologiia
https://www.readbyqxmd.com/read/28272108/looking-for-new-diagnostic-tools-and-biomarkers-of-hypertension-in-obese-pediatric-patients
#3
Wojciech Strojny, Dorota Drozdz, Kamil Fijorek, Michał Korostynski, Marcin Piechota, Walentyna Balwierz, Jacek A Pietrzyk, Przemko Kwinta, Maciej Siedlar, Szymon Skoczen
INTRODUCTION: Development of obesity in childhood may be linked to an increased risk of hypertension. OBJECTIVES: This study aimed (a) to analyze the expression of genes associated with blood pressure (BP) in obese children, (b) to evaluate ambulatory blood pressure monitoring (ABPM) as a diagnostic tool in hypertension in children, and (c) to assess the prevalence of metabolic syndrome in children with obesity. PATIENTS AND METHODS: Office BP measurements and ABPM were performed in 49 children with obesity and 25 age-matched healthy children...
March 7, 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/28265345/exercise-induced-albuminuria-vs-circadian-variations-in-blood-pressure-in-type-1-diabetes
#4
Isabelle Hota Tadida Meli, Aurel T Tankeu, Mesmin Y Dehayem, David Chelo, Jean Jacques N Noubiap, Eugene Sobngwi
AIM: To investigated the relationship between exercise-induced ambulatory blood pressure measurement (ABPM) abnormalities in type 1 diabetes mellitus (T1DM) adolescents. METHODS: We conducted a case-control at the National Obesity Center of the Yaoundé Central Hospital, Cameroon. We compared 24 h ABPM and urinary albumin-to-creatinine ratio (ACR) at rest and after a standardized treadmill exercise between 20 Cameroonian T1DM patients and 20 matched controls. T1DM adolescents were aged 12-18 years, with diabetes for at least one year, without proteinuria, with normal office blood pressure (BP) and renal function according to the general reference population...
February 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28218795/defensive-coping-and-essential-amino-acid-markers-as-possible-predictors-for-structural-vascular-disease-in-an-african-and-caucasian-male-cohort-the-sabpa-study
#5
Marisa Möller, Leoné Malan, Martin Magnusson, Carina M C Mels, Nico T Malan
Defensive coping (DefS), oxidative stress, inflammation, and related amino acids (phenylalanine [Phe] and tyrosine [Tyr]) have been implicated in cardiovascular disease. This study assessed whether inflammation, oxidative stress, changes in essential amino acids, and altered coping strategies are correlated with subclinical vascular changes in African (n = 82) and Caucasian (n = 100) men from the Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA) study. The Coping Strategy Indicator questionnaire identified DefS participants...
February 20, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28187896/hydra-a-web-based-system-for-cardiovascular-analysis-diagnosis-and-treatment
#6
J Novo, A Hermida, M Ortega, N Barreira, M G Penedo, J E López, C Calvo
BACKGROUND AND OBJECTIVE: Cardiovascular (CV) risk stratification is a highly complex process involving an extensive set of clinical trials to support the clinical decision-making process. There are many clinical conditions (e.g. diabetes, obesity, stress, etc.) that can lead to the early diagnosis or establishment of cardiovascular disease. In order to determine all these clinical conditions, a complete set of clinical patient analyses is typically performed, including a physical examination, blood analysis, electrocardiogram, blood pressure (BP) analysis, etc...
February 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28165190/metabolic-syndrome-and-masked-hypertension-among-african-americans-the-jackson-heart-study
#7
Lisandro D Colantonio, D Edmund Anstey, April P Carson, Gbenga Ogedegbe, Marwah Abdalla, Mario Sims, Daichi Shimbo, Paul Muntner
The metabolic syndrome is associated with higher ambulatory blood pressure. The authors studied the association of metabolic syndrome and masked hypertension (MHT) among African Americans with clinic-measured systolic/diastolic blood pressure (SBP/DBP) <140/90 mm Hg in the Jackson Heart Study. MHT was defined as daytime, nighttime, or 24-hour hypertension on ambulatory blood pressure monitoring. Among 359 participants not taking antihypertensive medication, the metabolic syndrome was associated with MHT (prevalence ratio, 1...
February 6, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28099229/twenty-four-hour-ambulatory-blood-pressure-monitoring-for-clinical-evaluation-of-hypertensive-patients-in-primary-care-which-groups-would-most-benefit
#8
COMPARATIVE STUDY
Guilherme B Grezzana, Airton T Stein, Lucia C Pellanda
BACKGROUND: Arterial hypertension is an important risk factor for cardiovascular outcomes. Blood pressure (BP) control levels remain largely out of target among primary healthcare (PHC) patients. Twenty-four-hour ambulatory blood pressure monitoring (ABPM) may contribute toward the identification of cardiovascular risk groups. OBJECTIVE: To assess concordance between conventional office BP measurements and 24-h ABPM of hypertension control in cardiovascular risk groups of PHC hypertensive patients...
April 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/28099129/the-association-between-obesity-hypertension-and-left-ventricular-mass-in-adolescents
#9
Saime Ergen Dibeklioglu, Berna Şaylan Çevik, Banu Acar, Zeynep Birsin Özçakar, Nermin Uncu, Nazlı Kara, Şemsa Çaycı, Nilgün Çakar
BACKGROUND: Obesity and hypertension (HT) are well known cardiac risk factors. Our goal was to show that even if arterial blood pressure (BP) measurements of obese adolescents are normal during clinical examination, ambulatory blood pressure monitoring (ABPM) can be high, may include cardiac involvement and can also detect left ventricular mass indices (LVMI) value for obese adolescents to diagnose left ventricular hypertrophy (LVH). METHODS: This study included 130 children (57 obese hypertensive, 36 obese normotensive, 14 normal weight hypertensive and 23 normal weight normotensive)...
February 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28075064/efficacy-of-nebivolol-valsartan-single-pill-combination-in-obese-and-nonobese-patients-with-hypertension
#10
Christian W Mende, Thomas D Giles, David B Bharucha, William G Ferguson, Madhuja Mallick, Mehul D Patel
Antihypertensive efficacy of single-pill combinations (SPCs) consisting of a β1 -selective adrenergic blocker with vasodilatory properties via β3 -agonism (nebivolol) and an angiotensin II receptor blocker (valsartan) was demonstrated in an 8-week phase 3 trial (NCT01508026). In this post hoc analysis, seated blood pressure, heart rate, 24-hour ambulatory blood pressure monitoring, plasma aldosterone, estimated glomerular filtration rate, and safety measures were assessed in obese (body mass index >32 kg/m(2) ; n=1823) and nonobese (body mass index <27 kg/m(2) ; n=847) adults with hypertension (stage I or II) treated with nebivolol-valsartan SPCs, nebivolol or valsartan monotherapy, or placebo...
January 11, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28027534/asymptomatic-hyperuricemia-is-a-strong-risk-factor-for-resistant-hypertension-in-elderly-subjects-from-general-population
#11
Alberto Mazza, Salvatore Lenti, Laura Schiavon, Alvise Del Monte, Danyelle M Townsend, Emilio Ramazzina, Domenico Rubello, Edoardo Casiglia
OBJECTIVE: In clinical practice, patient characteristics predicting resistant hypertension (RH) include higher blood pressure levels, left ventricular hypertrophy, older age, obesity, chronic kidney disease and diabetes. On the contrary little is known about the role of serum uric acid (SUA) as a risk factor for RH in subjects from general population. MATERIAL AND METHODS: 580 elderly subjects aged ≥65 years were enrolled in the Risk Of Vascular complications Impact of Genetics in Old people (ROVIGO) study...
February 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27957627/blood-pressure-response-to-catheter-based-renal-sympathetic-denervation-in-severe-resistant-hypertension-data-from-the-greek-renal-denervation-registry
#12
C Tsioufis, A Ziakas, K Dimitriadis, P Davlouros, M Marketou, A Kasiakogias, C Thomopoulos, D Petroglou, D Tsiachris, M Doumas, E Skalidis, C Karvounis, D Alexopoulos, P Vardas, I Kallikazaros, C Stefanadis, V Papademetriou, D Tousoulis
BACKGROUND/INTRODUCTION: The efficacy of catheter-based renal sympathetic denervation (RDN) in terms of blood pressure (BP) reduction has been questioned, while "real-world" data from registries are needed. In this study, we report the complete set of 12-month data on office and ambulatory BP changes as well as the predictors for BP response to RDN from a national registry. METHODS: In 4 Greek hospital centers, 79 patients with severe drug-resistant hypertension (age 59 ± 10 years, 53 males, body mass index 33 ± 5 kg/m(2); office BP and 24-h ambulatory BP were 176 ± 15/95 ± 13 and 155 ± 14/90 ± 12 mmHg, respectively, 4...
December 12, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27940662/deep-targeted-exon-sequencing-reveals-renal-polymorphisms-associate-with-postexercise-hypotension-among-african-americans
#13
Linda S Pescatello, Elizabeth D Schifano, Garrett I Ash, Gregory A Panza, Lauren Lamberti, Ming-Hui Chen, Ved Deshpande, Amanda Zaleski, Paulo Farinatti, Beth A Taylor, Paul D Thompson
We found variants from the Angiotensinogen-Converting Enzyme (ACE), Angiotensin Type 1 Receptor (AGTR1), Aldosterone Synthase (CYP11B2), and Adducin (ADD1) genes exhibited intensity-dependent associations with the ambulatory blood pressure (BP) response following acute exercise, or postexercise hypotension (PEH). In a validation cohort, we sequenced exons from these genes for their associations with PEH Obese (30.9 ± 3.6 kg m(-2)) adults (n = 23; 61% African Americans [AF], 39% Caucasian) 42.0 ± 9...
October 2016: Physiological Reports
https://www.readbyqxmd.com/read/27905219/early-24-hour-blood-pressure-response-to-roux-en-y-gastric-bypass-in-obese-patients
#14
Julie S Pedersen, Christian Borup, Morten Damgaard, Vindhya D Yatawara, Andrea K Floyd, Niels Gadsbøll, Peter K Bonfils
Recently, it has been proposed, that the blood pressure (BP) lowering effect of gastric bypass surgery not only is explained by the obtained weight loss, but that the anatomical rearrangement of the gut after 'malabsorptive' surgical techniques, such as the laparoscopic Roux-en-Y gastric bypass (LRYGB), may affect BP through a change in a putative 'entero-renal' axis. If so one could anticipate a reduction in BP even before a noticeable weight loss was obtained. The purpose of the present study was to investigate the very early BP response to LRYGB surgery...
February 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/27878804/assessment-of-cardiovascular-risk-in-patients-undergoing-total-joint-alloplasty-the-crash-joint-study
#15
Pawel Legosz, Marcin Kotkowski, Anna E Platek, Pawel Maldyk, Bartosz Krzowski, Anna Rys, Karolina Semczuk, Filip M Szymanski, Krzysztof J Filipiak
BACKGROUND: Risk assessment is of particular importance for patients undergoing surgical interventions. Orthopedic procedures, especially total joint alloplasty are major procedure associated with high perioperative risk, as well as one of the highest rates of complications. The aim of the present study was to establish the prevalence of classical and non-classical cardiovascular risk factors in patients undergoing total hip or knee alloplasty. METHODS: The CRASH-JOINT (Cardiovascular Risk Assessment ScHeme in JOINT alloplasty) was a prospective, epidemiological study performed in consecutive patients scheduled for total joint (hip or knee) replacement surgery...
November 23, 2016: Kardiologia Polska
https://www.readbyqxmd.com/read/27861249/the-antihypertensive-effects-of-aerobic-versus-isometric-handgrip-resistance-exercise
#16
Garrett I Ash, Beth A Taylor, Paul D Thompson, Hayley V MacDonald, Lauren Lamberti, Ming-Hui Chen, Paulo Farinatti, William J Kraemer, Gregory A Panza, Amanda L Zaleski, Ved Deshpande, Kevin D Ballard, Mohammadtokir Mujtaba, C Michael White, Linda S Pescatello
BACKGROUND: Aerobic exercise reduces blood pressure (BP) on average 5-7 mmHg among those with hypertension; limited evidence suggests similar or even greater BP benefits may result from isometric handgrip (IHG) resistance exercise. METHOD: We conducted a randomized controlled trial investigating the antihypertensive effects of an acute bout of aerobic compared with IHG exercise in the same individuals. Middle-aged adults (n = 27) with prehypertension and obesity randomly completed three experiments: aerobic (60% peak oxygen uptake, 30 min); IHG (30% maximum voluntary contraction, 4 × 2 min bilateral); and nonexercise control...
February 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/27810973/which-cuff-should-i-use-indirect-blood-pressure-measurement-for-the-diagnosis-of-hypertension-in-patients-with-obesity-a-diagnostic-accuracy-review
#17
Greg Irving, John Holden, Richard Stevens, Richard J McManus
OBJECTIVE: To determine the diagnostic accuracy of different methods of blood pressure (BP) measurement compared with reference standards for the diagnosis of hypertension in patients with obesity with a large arm circumference. DESIGN: Systematic review with meta-analysis with hierarchical summary receiver operating characteristic models. Bland-Altman analyses where individual patient data were available. Methodological quality appraised using Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS2) criteria...
November 3, 2016: BMJ Open
https://www.readbyqxmd.com/read/27797683/short-term-effects-of-green-tea-on-blood-pressure-endothelial-function-and-metabolic-profile-in-obese-prehypertensive-women-a-crossover-randomized-clinical-trial
#18
Lívia de P Nogueira, José Firmino Nogueira Neto, Márcia R S T Klein, Antonio F Sanjuliani
BACKGROUND: Green tea consumption has been inversely associated with cardiovascular disease (CVD) in epidemiological studies. Although some interventional trials suggest that green tea has beneficial effects on CVD risk factors, such as hypertension and obesity, others have failed to show such benefits. AIMS: To evaluate the short-term effects of green tea on blood pressure, endothelial function, metabolic profile, and inflammatory activity in obese prehypertensive women...
February 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/27779461/differential-effects-of-lercanidipine-enalapril-versus-amlodipine-enalapril-and-hydrochlorothiazide-enalapril-on-target-organ-damage-and-sympathetic-activation-in-non-obese-essential-hypertensive-subjects
#19
K Tsioufis, Costas Tsioufis, Kyriakos Dimitriadis, Emmanouil Mantzouranis, Ilianna Mani, Dimitrios Tousoulis
OBJECTIVE: The aim of the present study was to compare the effects of the combination of lercanidipine/enalapril versus amlodipine/enalapril and hydrochlorothiazide/enalapril on blood pressure, target organ damage and sympathetic activation in patients with grade 2 essential hypertension. RESEARCH DESIGN AND METHODS: This was a 3 month, randomized, blinded-endpoint study in essential hypertensive patients. MAIN OUTCOME MEASURES: Office and ambulatory blood pressure, arterial stiffness, urinary albumin to creatinine ratio, renal arterial resistive index, and muscle sympathetic nerve activity were evaluated at baseline, after a 2 week run-in placebo period, at 1 month and at 3 months...
October 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27776078/masked-hypertension-in-obesity-potential-predictors-and-arterial-damage
#20
MULTICENTER STUDY
Isabel E Kenny, Sahrai Saeed, Eva Gerdts, Helga Midtbø, Hilde Halland, Mai T Lønnebakken
BACKGROUND: Masked hypertension (MHT), defined as normal office blood pressure (BP) but high ambulatory BP, has been associated with increased cardiovascular risk. Although MHT has been associated with obesity, there is limited knowledge on the prevalence and covariates of MHT in obese cohorts. METHODS: Office and ambulatory BP recordings and other cardiovascular risk factors were assessed in 323 obese participants included in the fat-associated cardiovascular dysfunction study (mean age 48...
February 2017: Blood Pressure Monitoring
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