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Late onset asthma

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https://www.readbyqxmd.com/read/29758487/maternal-allergy-as-an-isolated-risk-factor-for-early-onset-preeclampsia-an-epidemiological-study
#1
Anne Kvie Sande, Erik Andreas Torkildsen, Ragnar Kvie Sande, Nils-Halvdan Morken
Immunological mechanisms underlying the development of preeclampsia are well known, but no association to allergy has yet been demonstrated. The aim of this study was to assess the correlation between maternal pre-gestational allergy, and early-onset and late-onset preeclampsia, respectively. It was a retrospective cohort study including all women giving birth in the Norwegian cities of Stavanger (1996-2014) and Bergen (2009-2014). Pre-gestational asthma, allergy, other known risk factors for preeclampsia, maternal age and parity were obtained from the electronic medical record system...
April 20, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29722559/mir-142-3p-is-associated-with-aberrant-wingless-integrase-i-wnt-signaling-during-airway-remodeling-in-asthma
#2
Sabine Bartel, Gianni Carraro, Francesca Alessandrini, Susanne Krauss-Etschmann, Fabio L M Ricciardolo, Saverio Bellusci
BACKGROUND: Asthma is characterized by a chronic inflammation and remodeling of the airways. While inflammation can be controlled, therapeutic options to revert remodeling do not exist. Thus, there is a large and unmet need to understand the underlying molecular mechanisms in order to develop novel therapies. OBJECTIVE: we previously identified a pivotal role for miR-142-3p in regulating airway smooth muscle precursor (ASM) cell proliferation during lung development by fine-tuning the Wingless/Integrase I (WNT) signaling...
May 3, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29713490/clinical-characteristics-and-comorbidities-of-elderly-asthmatics-who-attend-allergy-clinics
#3
Anahí Yáñez, Marcela Soria, Susana De Barayazarra, Nancy Recuero, Francisco Rovira, Edgardo Jares, Ana María Stok, Sergio Nemirovsky, Carlos Bueno
Background: To date, few studies have focused on the clinical and allergic characteristics of asthma in the elderly, defined as asthma in people aged 60 or over. Thus, we propose to identify and study the clinical and allergic characteristics and comorbidities of patients with asthma among the elderly. Methods: A retrospective, observational, descriptive study was developed in five clinics and hospitals in Argentina. Allergy Physicians analyzed their patients' medical records in 2014 and included those adults over the age of 60, who had been diagnosed with asthma according to the GINA guidelines...
2018: Asthma Research and Practice
https://www.readbyqxmd.com/read/29619222/laryngomalacia-presenting-as-severe-uncontrolled-asthma
#4
Kanami Tamura, Toshihiro Shirai, Aya Matsubara
Congenital laryngomalacia is the most common cause of stridor in infants and usually resolves without therapy by 12-18 months of age. However, a recent study found that laryngomalacia may leave structural and functional traces with increased risk of later respiratory symptoms, suggesting that late-onset laryngomalacia may represent long-term consequences of milder or even undiagnosed forms. Unusual cases demonstrated that inspiratory stridor developed subsequent to upper respiratory tract infections. The lack of airway hyperresponsiveness in adulthood also raised questions regarding the diagnosis of childhood asthma...
July 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29617923/breastfeeding-and-childhood-wheeze-age-specific-analyses-and-longitudinal-wheezing-phenotypes-as-complimentary-approaches-to-the-analysis-of-cohort-data
#5
Maria A Quigley, Claire Carson, Yvonne Kelly
Systematic reviews suggest that breastfeeding is associated with a lower risk of asthma, although marked heterogeneity exists. Using UK Millennium Cohort Study data (n = 10,126 children born 2000-2001), we examined the association between breastfeeding duration and wheezing in the past year, first at each age-group separately (age 9 months, 3, 5, 7 and 11 years) and then as a longitudinal wheezing phenotype: 'early transient' (wheezing any time up to age 5 but not thereafter); 'late onset' (any time from age 7 but not beforehand); 'persistent' (any time up to age 5 and any time from age 7)...
April 3, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29540228/early-life-exposure-to-three-size-fractionated-ultrafine-and-fine-atmospheric-particulates-in-beijing-exacerbates-asthma-development-in-mature-mice
#6
Mei Mei, Haojun Song, Lina Chen, Bin Hu, Ru Bai, Diandou Xu, Ying Liu, Yuliang Zhao, Chunying Chen
BACKGROUND: Epidemiological studies have suggested that elevated levels of air pollution contribute to an increased incidence or severity of asthma. Although late-onset adult asthma seems to be more attributable to environmental risk factors, limited data is available on the impact of early-life exposure to size-fractionated ambient particulate matter (PM) on asthma in adults. We aimed to determine the effect on the development and exacerbation of asthma in the adult after the mice were exposed as juveniles to three size-fractionated ambient particulates collected from Beijing...
March 14, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29518830/-a-follow-up-study-of-six-years-outcome-of-children-with-asthma-in-urban-area-of-beijing
#7
C Y Tian, L Sha, C H Liu, Y Q Luo, S Li, M Y Zhao, W Wang, Y Z Chen
Objective: To understand the outcome of asthma in children from urban area of Beijing and the factors associated with the outcome. Methods: A total of 497 children with asthma diagnosed in the epidemiological survey of childhood asthma in urban area of Beijing in 2010 were selected in this study. Telephone follow-up was conducted in 2016 to obtain information about asthma attack, emergency visit, hospitalization, medication and disease control, and data of comorbidities of allergic diseases from 1 year earlier...
March 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29512835/childhood-asthma-and-smoking-exposures-before-conception-a-three-generational-cohort-study
#8
Lennart Bråbäck, Caroline J Lodge, Adrian J Lowe, Shyamali C Dharmage, David Olsson, Bertil Forsberg
BACKGROUND: Some human and animal studies have recently shown that maternal grandmother's smoking during pregnancy increases the risk of asthma in the grandchildren. We have investigated whether sex of the exposed parent and/or grandchild modifies the association between grandmaternal smoking and grandchild asthma. METHODS: We formed a cohort study based on linkage of national registries with prospectively collected data over three generations. Smoking habits in early pregnancy were registered since 1982 and purchases of prescribed medication since 2005...
March 7, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29445292/late-onset-asthma-current-perspectives
#9
REVIEW
Tsunahiko Hirano, Kazuto Matsunaga
Because the pathophysiology of asthma has diverse characteristics, to manage the disease effectively, it is important for clinicians to distinguish among the clinical phenotypes. Among them, adult-onset asthma, that is, late-onset asthma (LOA), is increasing because of the aging of the population. The phenotype of LOA is largely divided into two types according to the presence or absence of eosinophilic inflammation, T-helper (Th)2- and non-Th2-associated LOA. Especially in Th2 LOA related to rhinosinusitis, as pulmonary function at onset is poor and asthma exacerbations occur frequently, it is important to detect this phenotype in the early phase by using a biomarker of Th2-type inflammation such as fractional exhaled nitric oxide (FENO )...
2018: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29432969/age-related-prevalence-of-chronic-rhinosinusitis-and-nasal-polyps-and-their-relationships-with-asthma-onset
#10
Ha-Kyeong Won, Young-Chan Kim, Min-Gyu Kang, Han-Ki Park, Seung-Eun Lee, Min-Hye Kim, Min-Suk Yang, Yoon-Seok Chang, Sang-Heon Cho, Woo-Jung Song
BACKGROUND: Chronic rhinosinusitis (CRS) is a major disease condition with high morbidity and can influence lower airway disease status in adults. However, its associations with adult asthma onset and activity have not been examined in detail in a general adult population. OBJECTIVE: To investigate relationships between CRS with nasal polyps (CRSwNP) and asthma characteristics. METHODS: A cross-sectional data set of 17,506 adult participants (≥18 years old) in the Korean National Health and Nutrition Examination Survey from 2010 through 2012 was analyzed...
April 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29355680/early-life-risk-factors-for-chronic-sinusitis-a-longitudinal-birth-cohort-study
#11
Eugene H Chang, Debra A Stern, Amanda L Willis, Stefano Guerra, Anne L Wright, Fernando D Martinez
BACKGROUND: Chronic sinusitis is a commonly diagnosed condition in adults who frequently present with late-stage disease and irreversible changes to the sinus mucosa. Understanding the natural history of chronic sinusitis is critical in developing therapies designed to prevent or slow the progression of disease. OBJECTIVE: We sought to determine early life risk factors for adult sinusitis in a longitudinal cohort study (Tucson Children's Respiratory Study). METHODS: Physician-diagnosed sinusitis was reported at age 6...
April 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29331049/prenatal-maternal-psychosocial-stress-and-offspring-s-asthma-and-allergic-disease-a-systematic-review-and-meta-analysis
#12
C Flanigan, A Sheikh, A DunnGalvin, B K Brew, C Almqvist, B I Nwaru
BACKGROUND: Prenatal maternal stress may influence offspring's atopic risk through sustained cortisol secretion resulting from activation of the hypothalamic-pituitary axis (HPA), leading to Th2-biased cell differentiation in the foetus. We undertook a systematic review and meta-analysis investigating the relationship between prenatal maternal psychosocial stress and risk of asthma and allergy in the offspring. METHODS: We searched 11 electronic databases from 1960 to 2016, searched the grey literature and contacted experts in the field...
April 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29316300/asthma-onset-pattern-and-patient-outcomes-in-a-chronic-rhinosinusitis-population
#13
Christopher John Staniorski, Caroline P E Price, Ava R Weibman, Kevin C Welch, David B Conley, Stephanie Shintani-Smith, Whitney W Stevens, Anju T Peters, Leslie Grammer, Alcina K Lidder, Robert P Schleimer, Robert C Kern, Bruce K Tan
BACKGROUND: Chronic rhinosinusitis (CRS) is strongly associated with comorbid asthma. This study compares early-onset and late-onset asthma in a CRS population using patient-reported and clinical characteristics. METHODS: At enrollment into a clinical registry, CRS patients completed the 22-item Sino-Nasal Outcome Test (SNOT-22), Asthma Control Test (ACT), mini-Asthma Quality of Life Questionnaire (miniAQLQ), the 29-item Patient-Reported Outcomes Measurement Information System (PROMIS-29), and medication use questionnaires...
April 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29221262/differences-in-airway-remodeling-and-airway-inflammation-among-moderate-severe-asthma-clinical-phenotypes
#14
Wen-Jing Ye, Wei-Guo Xu, Xue-Jun Guo, Feng-Feng Han, Juan Peng, Xiao-Ming Li, Wen-Bin Guan, Li-Wei Yu, Jin-Yuan Sun, Zhi-Lei Cui, Lin Song, Yue Zhang, Yan-Min Wang, Tian-Yun Yang, Xia-Hui Ge, Di Yao, Song Liu
Background: To identify asthma clinical phenotypes using cluster analysis and improve our understanding of heterogeneity in asthma. Methods: Clustering approaches were applied to 203 patients who were diagnosed with asthma in XinHua Hospital (January 2012 to December 2015). One hundred and twenty patients underwent multi-slice spiral computed tomography (MSCT) examination and 30 underwent bronchial mucosal biopsy for evaluation of airway remodeling and airway inflammation among the phenotypes...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29217598/phenotypes-of-symptomatic-airways-disease-in-china-and-new-zealand
#15
James Fingleton, Kewu Huang, Mark Weatherall, Yanfei Guo, Stefan Ivanov, Piet Bruijnzeel, Hong Zhang, Wei Wang, Richard Beasley, Chen Wang
It is uncertain whether phenotypes of asthma and chronic obstructive pulmonary disease (COPD) vary between populations with different genetic and environmental characteristics. Here, our objective was to compare the phenotypes of airways disease in two separate populations.This was a cross-sectional observational study in adult populations from New Zealand and China. Participants aged 40-75 years who reported wheeze and breathlessness in the last 12 months were randomly selected from the general population and underwent detailed characterisation...
December 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29129583/identification-of-atopic-dermatitis-subgroups-in-children-from-2-longitudinal-birth-cohorts
#16
Lavinia Paternoster, Olga E M Savenije, Jon Heron, David M Evans, Judith M Vonk, Bert Brunekreef, Alet H Wijga, A John Henderson, Gerard H Koppelman, Sara J Brown
BACKGROUND: Atopic dermatitis (AD) is a prevalent disease with variable natural history. Longitudinal birth cohort studies provide an opportunity to define subgroups on the basis of disease trajectories, which may represent different genetic and environmental pathomechanisms. OBJECTIVES: We sought to investigate the existence of distinct longitudinal phenotypes of AD and test whether these findings are reproducible in 2 independent cohorts. METHODS: The presence of AD was examined in 2 birth cohort studies including 9894 children from the United Kingdom (ALSPAC) and 3652 from the Netherlands (PIAMA)...
March 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29101938/practical-considerations-for-the-diagnosis-and-management-of-asthma-in-older-adults
#17
REVIEW
Barbara P Yawn, MeiLan K Han
Although often considered a disease of childhood, the prevalence of asthma in US adults aged 65 years or older is similar to that in children, with the number of older patients needing care for asthma likely to continue to increase. As with most chronic diseases, there are challenges associated with the diagnosis and management of asthma in an older population. This review discusses these challenges, suggesting practical management strategies for primary care physicians and their teams. Asthma comprises a spectrum of phenotypes, some associated with adult onset...
November 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29094021/the-asthma-and-chronic-obstructive-pulmonary-disease-overlap-syndrome-in-tertiary-care-setting-thailand
#18
Theerasuk Kawamatawong, Sanruethai Charoenniwassakul, Ticha Rerkpattanapipat
Background: Asthma and chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is an increasingly recognized clinical entity. ACOS significantly impacts on patient outcome compared to isolated asthma or COPD. However, ACOS definition and diagnosis criteria have not been well standardized. ACOS prevalence and clinical features in Thailand has never been studied. Objective: To investigate the prevalence and clinical features of ACOS compared to isolated asthma or COPD among patients with clinician-diagnosis of obstructive airway diseases...
October 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29072882/rita-the-italian-severe-uncontrolled-asthma-registry
#19
S Maio, S Baldacci, M Bresciani, M Simoni, M Latorre, N Murgia, F Spinozzi, M Braschi, L Antonicelli, B Brunetto, P Iacovacci, P Roazzi, C Pini, M Pata, L La Grasta, P Paggiaro, G Viegi
BACKGROUND: The Italian severe/uncontrolled asthma (SUA) web-based registry encompasses demographic, clinical, functional, and inflammatory data; it aims to raise SUA awareness, identifying specific phenotypes and promoting optimal care. METHODS: Four hundred and ninety three adult patients from 27 Italian centers (recruited in 2011-2014) were analyzed. RESULTS: Mean age was 53.8 years. SUA patients were more frequently female (60.6%), with allergic asthma (83...
March 2018: Allergy
https://www.readbyqxmd.com/read/29046036/-spontaneous-pneumomediastinum-and-subcutaneous-emphysema-associated-with-bronchospasm-in-a-woman-with-no-history-of-asthma
#20
Tonatiuh Ramses Bedolla-Pulido, Martín Bedolla-Barajas
BACKGROUND: Spontaneous pneumomediastinum most relevant triggering events are cough, vomiting, nutritional problems, physical activity and use of inhaled drugs. Association of spontaneous pneumomediastinum with non-asthma-related bronchospasm is an infrequent event. CLINICAL CASE: This is the case of a 21-year-old woman without personal or family history of asthma, allergic rhinitis or atopy who during late puerperium had 39 °C fever, paroxysmal cough and chest oppression of sudden onset, as well as wheezing and subcutaneous emphysema of the neck; she had no previous nasal symptoms...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
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