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Gastrointestinal tumors stromal

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https://www.readbyqxmd.com/read/28798000/epidemiology-and-survival-analysis-of-gastrointestinal-stromal-tumors-in-lebanon-real-life-study-from-a-hospital-tumor-registry-2000-2015
#1
Elie El Rassy, Fadi Nasr, Tarek Assi, Toni Ibrahim, Nathalie Rassy, Joseph Bou Jaoude, Marcel Massoud, Georges Chahine
BACKGROUND: We report, to our knowledge, one of the largest studies concerning gastrointestinal stromal tumors (GIST) in the Middle East. We also present a survival analysis of GIST in our 15-year real-life experience. METHODS: We studied demographic, epidemiologic and survival characteristics of 70 patients with confirmed GIST in a cross-sectional study between 2000 and 2015. RESULTS: The median age of our patients was 62 ±12.8 years (range, 25-84) with a male to female ratio of 1...
May 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28796048/clinicopathologic-study-of-succinate-dehydrogenase-deficient-gastrointestinal-stromal-tumors-a-single-institutional-experience-in-china
#2
Weizhen Liu, Xiangyu Zeng, Xiuli Wu, Jun He, Jinbo Gao, Xiaoming Shuai, Guobin Wang, Peng Zhang, Kaixiong Tao
Gastrointestinal stromal tumors (GISTs) that are not driven by kinase mutations, as are most GISTs, often show loss of function of the succinate dehydrogenase (SDH) complex and are considered SDH-deficient GISTs. SDH-deficient GISTs share many distinct characteristics compared with conventional GISTs. However, data regarding these characteristics, particularly among Asian people, are relatively limited. The objective of this study was to characterize the clinicopathologic characteristics, treatment, and prognosis of these uncommon GISTs...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28795041/extra-gastrointestinal-stromal-tumor-presenting-as-an-anterior-chest-wall-mass
#3
Junghyeon Lim, Sung Woo Cho, Hee Sung Lee, Hyoung Soo Kim, Yong Han Kim, Bong Suk Park
A 71-year-old man was referred for an anterior chest wall mass. Chest computed tomography (CT) and positron emission tomography-CT suggested a malignant tumor. Surgical biopsy through a vertical subxiphoid incision revealed an extra-gastrointestinal stromal tumor (EGIST). En bloc resection of the tumor, including partial resection of the sternum, costal cartilage, pericardium, diaphragm, and peritoneum, was performed. Pathologic evaluation revealed a negative resection margin and confirmed the tumor as an EGIST...
August 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28791999/-clinical-and-morphological-characteristics-of-gastrointestinal-stromal-tumors
#4
D D Khalikov, F Sh Akhmetzyanov, S V Petrov
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Despite this, GISTS comprise about 2% in the structure of digestive tract cancers. They are usually localized in the stomach; however, they can be found in the small intestine and more rarely in the colon and esophagus. Although approximately 70% of the GISTs consist predominantly of spindle cells; the epithelioid cell tumors represent 20% of cases; there are also mixed variants. This variability in the morphological structure of GISTs complicates their diagnosis...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28783738/improvement-to-ultrasonographical-differential-diagnosis-of-gastric-lesions-the-value-of-contrast-enhanced-sonography-with-gastric-distention
#5
Tingting Li, Man Lu, Jun Song, Ping Wu, Xueqing Cheng, Zhenqi Zhang
OBJECTIVE: The purpose of this retrospective study is to evaluate the diagnostic value of contrast enhanced sonography plus gastric distention sonography, the Double Contrast-enhanced Ultrasound (DCUS) in gastric lesions. METHODS: 107 cases with pathology confirmed gastric lesions were retrospectively reviewed, DCUS and oral contrast agent ultrasound (US) were performed in all cases prior to operation. Perfusion parameters including arrival time (AT), peak intensity (PI), time to peak (TTP), and area under the curve (AUC) of the lesion and surrounding normal tissue were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28782509/subepithelial-esophageal-tumors-a-single-center-review-of-resected-and-surveilled-lesions
#6
Don C Codipilly, Hongfei Fang, Jeffrey A Alexander, David A Katzka, Karthik Ravi
BACKGROUND AND AIMS: Subepithelial esophageal tumors (SETs) are frequent incidental findings. Although symptomatic tumors are surgically or endoscopically resected, there is no consensus on the management of asymptomatic esophageal leiomyomas. METHODS: Appropriate ICD-9 codes followed by medical record review were used to identify patients with SETs from January 1992 to March 2017, with abstraction of basic demographics, surveillance intervals, and mortality. Patients were contacted to complete a phone questionnaire to assess follow-up and complete the validated brief esophageal dysphagia questionnaire (BEDQ)...
August 3, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28777148/new-mechanisms-of-mtor-pathway-activation-in-kit-mutant-malignant-gists
#7
Jerzy Lasota, Artur Kowalik, Anna Felisiak-Golabek, Sebastian Zięba, Zeng-Feng Wang, Markku Miettinen
A great majority of gastrointestinal stromal tumors (GISTs) are primarily driven by gain-of-function KIT receptor tyrosine kinase mutations that subsequently lead to activation of phosphatidiylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway, a downstream effector of KIT signaling. KIT tyrosine kinase inhibitor, imatinib mesylate, has been successfully used for the treatment of primary, advanced, and disseminated GISTs. Recently, activation of mTOR pathway independent of KIT signaling was demonstrated in imatinib mesylate naïve malignant GISTs and treatment-resistant metastatic tumors...
August 2, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28768491/succinate-dehydrogenase-deficiency-in-a-pdgfra-mutated-gist
#8
Martin G Belinsky, Kathy Q Cai, Yan Zhou, Biao Luo, Jianming Pei, Lori Rink, Margaret von Mehren
BACKGROUND: Most gastrointestinal stromal tumors (GISTs) harbor mutually exclusive gain of function mutations in the receptor tyrosine kinase (RTK) KIT (70-80%) or in the related receptor PDGFRA (~10%). These GISTs generally respond well to therapy with the RTK inhibitor imatinib mesylate (IM), although initial response is genotype-dependent. An alternate mechanism leading to GIST oncogenesis is deficiency in the succinate dehydrogenase (SDH) enzyme complex resulting from genetic or epigenetic inactivation of one of the four SDH subunit genes (SDHA, SDHB, SDHC, SDHD, collectively referred to as SDHX)...
August 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28760855/dual%C3%A2-targeting%C3%A2-of%C3%A2-insulin%C3%A2-receptor%C3%A2-and%C3%A2-kit%C3%A2-in%C3%A2-imatinib-resistant%C3%A2-gastrointestinal%C3%A2-stromal%C3%A2-tumors
#9
Weicai Chen, Ye Kuang, Hai-Bo Qiu, Zhifa Cao, Yuqing Tu, Qing Sheng, Grant Eilers, Quan He, Hai-Long Li, Meijun Zhu, Yuexiang Wang, Rongqing Zhang, Yeqing Wu, Fanguo Meng, Jonathan A Fletcher, Wen-Bin Ou
Oncogenic KIT or PDGFRA receptor tyrosine kinase (RTK) mutations are compelling therapeutic targets in gastrointestinal stromal tumors (GIST), and treatment with the KIT/PDGFRA inhibitor imatinib is the standard of care for patients with metastatic GIST. Most GIST eventually acquire imatinib resistance due to secondary mutations in the KIT kinase domain, but it is unclear whether these genomic resistance mechanisms require other cellular adaptations to create a clinically meaningful imatinib-resistant state...
July 31, 2017: Cancer Research
https://www.readbyqxmd.com/read/28759526/68ga-psma-uptake-in-an-incidentally-detected-gastrointestinal-stromal-tumor-in-a-case-of-suspected-carcinoma-prostate
#10
Arun Sasikumar, Ajith Joy, Mra Pillai, Bindu S, Sudin Sr
A 74-year-old man with suspected prostate cancer and a previously negative transrectal ultrasound-guided prostate biopsy underwent Ga-PSMA PET/CT. Scan showed no abnormal tracer concentration in enlarged prostate gland to suggest prostate cancer. Note was made of an incidentally detected well defined soft tissue lesion in the greater curvature of the stomach with moderate tracer concentration in its intraluminal portion. Biopsy of the lesion revealed gastrointestinal stromal tumor.
July 29, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28756979/thymosin-beta-4-overexpression-correlates-with-high-risk-groups-in-gastric-gastrointestinal-stromal-tumors-a-retrospective-analysis-by-immunohistochemistry
#11
Sevinç Şahin, Ozgur Ekinci, Selda Seçkin, Ayse Dursun
BACKGROUND: Thymosin beta-4 (Tβ4) is a protein that is linked to a number of important biological actions and recently tumor progression and poor prognosis of some tumors. The aim of this study was to evaluate Tβ4 expression in gastric GISTs and correlate with some clinicopathological characteristics related with prognosis and clinical outcome in order to add further data to the current literature. METHODS: Tβ4 antibody was applied to the 4μm-thick paraffin sections of 57 gastric GISTs by immunohistochemistry...
July 6, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28754403/-clinical-and-pathological-features-of-gastrointestinal-stromal-tumors-gist-in-a-single-institution-a-descriptive-study-and-review-of-the-literature
#12
Diego Flores-Funes, Ramón José Lirón-Ruiz, Carmen Victoria Pérez-Guarinos, Juan Gervasio Martín-Lorenzo, José Antonio Torralba-Martínez, Alberto Giménez-Bascuñana, María Asunción Chaves-Benito, José Luis Aguayo-Albasini
AIMS: This study was aimed to assess the main clinical, pathological and therapeutic characteristics of a cohort of gastrointestinal stromal tumors (GIST). MATERIAL AND METHOD: Observational study including 66 patients diagnosed with GIST admitted to our hospital between 2002 and 2015. Parameters related to medical history, clinical manifestations, medical and surgical treatment, histopathology, and morbi-mortality were studied. A review of the literature was included to correlate with the results...
July 25, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28750384/gastrointestinal-stromal-tumor
#13
(no author information available yet)
No abstract text is available yet for this article.
2017: Monographs in Clinical Cytology
https://www.readbyqxmd.com/read/28749793/pax8-expression-in-solitary-fibrous-tumor-a-potential-diagnostic-pitfall
#14
David Ullman, Jennifer Gordetsky, Gene P Siegal, Carlos N Prieto-Granada, Shi Wei, Todd M Stevens
PAX8 is used as a diagnostic aid in classifying retroperitoneal (RP) spindle cell tumors. PAX8 positivity in a spindled RP tumor is typically associated with sarcomatoid renal cell carcinoma (SRCC). However, PAX8 expression in solitary fibrous tumor (SFT), a tumor not uncommon to the RP, has not been extensively studied. We investigated the expression of PAX8 in SFTs and other spindle cell RP tumors. We collected 30 SFT, 23 SRCC, 11 gastrointestinal stromal tumors, 2 synovial sarcomas, 6 dedifferentiated liposarcomas (DDLS), 4 well differentiated liposarcomas (WDLS), and select other tumors...
July 26, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28749001/-carney-triad-report-of-one-case
#15
Jorge Vega, Jorge Navarro Subiabre, Cristian Lovera Riquelme, Héctor Opazo, Mario Santamarina
Carney described a disorder characterized by the presence of several uncommon tumors which were pulmonary chondromas, gastric sarcomas and extra-adrenal paragangliomas. We report a 14 year-old girl in whom multiple gastric tumors were discovered during a study of an iron deficiency anemia and was subjected to a partial gastrectomy. At 25 years of age, she developed several pulmonary chondromas and at 33 years, a mediastinal tumor with features of an extra-adrenal paraganglioma was found. At 35 years of age, a total gastrectomy was performed to remove a gastrointestinal stromal tumor with excision of peritoneal and lymph node metastasis...
April 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28748443/adherence-to-guidelines-for-adult-non-gist-soft-tissue-sarcoma-in-the-netherlands-a-plea-for-dedicated-sarcoma-centers
#16
Harald J Hoekstra, Rick L M Haas, Cornelis Verhoef, Albert J H Suurmeijer, Carla S P van Rijswijk, Ben G H Bongers, Winette T van der Graaf, Vincent K Y Ho
INTRODUCTION: Optimal management of soft tissue sarcoma (STS) remains a challenge. A nationwide survey assessed the quality of STS care in the Netherlands, thereby aiming to identify potentialities for improvement through more centralized disease management. METHODS: From the Netherlands Cancer Registry (NCR), data were obtained on 3317 adult STS patients (excluding gastrointestinal stromal tumor, GIST) diagnosed in 2006-2011. Logistic regression models were employed to compare outcomes on selected clinical indicators reflecting prevailing STS guidelines between high-volume (≥10 resections annually) and low-volume (<10 resections) hospitals, between academic and general hospitals, and between sarcoma research centers and other hospitals, adjusted for case mix...
July 26, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28746915/molecular-and-functional-characterization-of-a-new-3-end-kit-juxtamembrane-deletion-in-a-duodenal-gist-treated-with-neoadjuvant-imatinib
#17
Vittorio Perfetti, Erik Laurini, Suzana Aulić, Maurizio Fermeglia, Roberta Riboni, Marco Lucioni, Elena Dallera, Sara Delfanti, Luigi Pugliese, Francesco Saverio Latteri, Andrea Pietrabissa, Sabrina Pricl
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. GISTs express the receptor tyrosine kinase KIT, and the majority of GISTs present KIT gain-of-function mutations that cluster in the 5' end of the receptor juxtamembrane domain. On the other hand, little information is known about GISTs carrying mutations in the 3' end of the KIT juxtamembrane domain. Here we report and discuss a clinical case of localized duodenal GIST whose molecular characterization revealed the presence of a new 21 nucleotide/7 amino acid deletion in the 3' end of KIT juxtamembrane domain (Δ574-580)...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28740967/incidental-gastrointestinal-stromal-tumor-at-a-gastroscopic-polypectomy-specimen-a-case-report-and-review-of-literature
#18
Dursun Özgür Karakaş, Özgür Dandin, Ahmet Ziya Balta, Yavuz Özdemir, İsmail Yılmaz, İlker Sücüllü
Although gastrointestinal stromal tumors (GISTs) comprise less than 1% of all gastrointestinal (GI) tract tumors, they are the most common mesenchymal tumors of the GI tract. Gastrointestinal stromal tumors can occur anywhere along the GI tract, but the stomach and small intestine are the most frequently involved sites. Gastrointestinal stromal tumors are frequently asymptomatic, and one-third of all cases are found incidentally. Endoscopy, endoscopic ultrasonography, and computed tomography are useful tools in the diagnosis...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28740348/comparison-of-short-and-long-term-outcomes-of-laparoscopic-vs-open-resection-for-gastric-gastrointestinal-stromal-tumors
#19
Xin Ye, Wei-Ming Kang, Jian-Chun Yu, Zhi-Qiang Ma, Zhi-Gang Xue
AIM: To compare the short- and long-term outcomes of laparoscopic (LR) vs open resection (OR) for gastric gastrointestinal stromal tumors (gGISTs). METHODS: In total, 301 consecutive patients undergoing LR or OR for pathologically confirmed gGISTs from 2005 to 2014 were enrolled in this retrospective study. After exclusion of 77 patients, 224 eligible patients were enrolled (122 undergoing LR and 102 undergoing OR). The demographic, clinicopathologic, and survival data of all patients were collected...
July 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28739378/succinate-dehydrogenase-sdh-deficiency-carney-triad-and-the-epigenome
#20
REVIEW
Nikolaos Settas, Fabio R Faucz, Constantine A Stratakis
In this report, we review the relationship between succinate dehydrogenase (SDH) deficiency and the epigenome, especially with regards to two clinical conditions. Carney triad (CT) is a very rare disease with synchronous or metachronous occurrence of at least three different tumor entities; gastric gastrointestinal stromal tumor (GIST), paraganglioma (PGL), and pulmonary chondroma. This condition affects mostly females and it is never inherited. Another disease that shares two of the tumor components of CT, namely GIST and PGL is the Carney-Stratakis syndrome (CSS) or dyad...
July 21, 2017: Molecular and Cellular Endocrinology
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