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Glycemic control and diet

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https://www.readbyqxmd.com/read/27921432/-composition-of-macronutrients-in-the-diabetic-diet
#1
Zdeněk Rušavý, Michal Žourek
The diabetic diet is one of the pillars of diabetes treatment. The rapid development of knowledge relating to the treatment of diabetes also includes diet. The paper focuses on the importance of a diet in the treatment of type 2 diabetes and prevention of atherosclerosis. Its main goal is to assess the impact of a composition of macronutrients on individuals with type 2 diabetes. The paper is divided into several parts, each of which ends with a conclusion. The first part examines weight reduction. The diet aimed at a weight loss is effective, it can effectively prevent diabetes, it leads to improvements in glucose control and reduction of the risk factors for atherosclerosis, however it will not impact on cardiovascular morbidity and mortality until after more than 20 years...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27921426/-gestational-diabetes-mellitus
#2
Hana Krejčí
The present generation of women of childbearing age more frequently suffer from overweight, obesity, initial as well as fully established metabolic syndrome, which together with postponing motherhood until the third decade in life plays an important role in the increasing incidence of gestational diabetes (GDM) that currently affects about 1/5 of pregnant women. However the causal link between diabetes during pregnancy and metabolic diseases in the whole population is mutual. By way of epigenetic changes, maternal diabetes unfavourably programmes metabolism of the offspring, who tend to transfer the disorder to the next generations...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27917035/polyglandular-autoimmune-syndrome-in-pregnancy-case-report
#3
Basilio Pecorino, Maria Cristina Teodoro, Paolo Scollo
Type III Polyglandular Autoimmune Syndrome is a multiple endocrine disorders disease determined by autoimmunity; it can be diagnosed if a patient is affected by Type 1 Diabetes Mellitus and another autoimmune disease, except Addison Disease, for example Autoimmune Hashimoto Thyroiditis or Celiac Disease. R.D., 34-year-old woman (gravida 2 para 1), was referred to the High Risk Pregnancy Outpatient Clinic at Cannizzaro Hospital in Catania at 8 weeks' gestation. She was affected from type III Polyglandular Autoimmune Disease (Type 1 Diabetes Mellitus, Autoimmune Hashimoto Thyroiditis and Celiac Disease)...
September 2016: Italian Journal of Gynaecology & Obstetrics: Official Publication of the Societa Italiana di Ginecologia e Ostetricia (SIGO)
https://www.readbyqxmd.com/read/27913012/hyperglycemic-high-anion-gap-metabolic-acidosis-in-patients-receiving-sglt-2-inhibitors-for-diabetes-management
#4
Juliette Sandifer Kum-Nji, Aidar R Gosmanov, Helmut Steinberg, Samuel Dagogo-Jack
Sodium-glucose cotransporter-2 inhibitors (SGLT-2i) are a class of antidiabetic medications that improve glycemic control via inhibiting the reabsorption of filtered glucose and are approved for use in type 2 diabetes (T2DM). These drugs have recently been associated with euglycemic diabetic ketoacidosis (DKA). An increasing number of cases of SGLT-2i-associated DKA have occurred in patients with T2DM. Herein, we describe five episodes of hyperglycemic DKA in four type 2 diabetes patients receiving SGLT-2i therapy...
November 9, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27911357/characterization-of-metabolic-status-in-nonhuman-primates-with-the-intravenous-glucose-tolerance-test
#5
Michael Staup, George Aoyagi, TeQuana Bayless, Yixin Wang, Keefe Chng
The intravenous glucose tolerance test (IVGTT) plays a key role in the characterization of glucose homeostasis. When taken together with serum biochemical profiles, inclusive of blood glucose levels in both the fed and fasted state, HbA1c, insulin levels, clinical history of diet, body composition, and body weight status, an assessment of normal and abnormal glycemic control can be made. Interpretation of an IVGTT is done through measurement of changes in glucose and insulin levels over time in relation to the dextrose challenge...
November 13, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27904578/low-energy-density-diet-weight-loss-maintenance-and-risk-of-cardiovascular-disease-following-a-recent-weight-reduction-program-a-randomized-control-trial
#6
Golgis Karimi, Leila Azadbakht, Fahimeh Haghighatdoost, Ahmad Esmaillzadeh
BACKGROUND: Little is known about the effects of a low energy dense diet on weight maintenance and cardiovascular risks following a recent weight reduction. Therefore, we assessed if weight maintenance, lipid profiles, and glycemic control differ between low energy density (LED) diet and usual diet consumers following a recent weight reduction. MATERIALS AND METHODS: In this randomized controlled clinical trial study in a parallel design, we recruited 70 patients with the history of weight reduction in the recent 1 year...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27903748/hepatic-expression-of-adenovirus-36-e4orf1-improves-glycemic-control-and-promotes-glucose-metabolism-via-akt-activation
#7
Travis B McMurphy, Wei Huang, Run Xiao, Xianglan Liu, Nikhil V Dhurandhar, Lei Cao
Considering that impaired proximal insulin signaling is linked with diabetes, approaches that enhance glucose disposal independent of insulin signaling are attractive. In vitro data indicate that the E4ORF1 peptide derived from human adenovirus 36 (Ad36) interacts with cells from adipose tissue, skeletal muscle and liver to enhance glucose disposal, independent of proximal insulin signaling. Adipocyte-specific expression of Ad36E4ORF1 improved hyperglycemia in mice. To determine the hepatic interaction of Ad36E4ORF1 in enhancing glycemic control, we expressed E4ORF1 of Ad36 or adenovirus 5, or fluorescent tag alone using recombinant adeno-associated viral vector in the livers of three mouse models...
November 30, 2016: Diabetes
https://www.readbyqxmd.com/read/27903520/visceral-adiposity-and-metabolic-syndrome-after-very-high-fat-and-low-fat-isocaloric-diets-a-randomized-controlled-trial
#8
Vivian L Veum, Johnny Laupsa-Borge, Øyvin Eng, Espen Rostrup, Terje H Larsen, Jan Erik Nordrehaug, Ottar K Nygård, Jørn V Sagen, Oddrun A Gudbrandsen, Simon N Dankel, Gunnar Mellgren
BACKGROUND: Different aspects of dietary pattern, including macronutrient and food profiles, may affect visceral fat mass and metabolic syndrome. OBJECTIVE: We hypothesized that consuming energy primarily from carbohydrate or fat in diets with similar food profiles would differentially affect the ability to reverse visceral adiposity and metabolic syndrome. DESIGN: Forty-six men (aged 30-50 y) with body mass index (in kg/m(2)) >29 and waist circumference >98 cm were randomly assigned to a very high-fat, low-carbohydrate (VHFLC; 73% of energy fat and 10% of energy carbohydrate) or low-fat, high-carbohydrate (LFHC; 30% of energy fat and 53% of energy carbohydrate) diet for 12 wk...
November 30, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27894316/dietary-patterns-in-obese-pregnant-women-influence-of-a-behavioral-intervention-of-diet-and-physical-activity-in-the-upbeat-randomized-controlled-trial
#9
Angela C Flynn, Paul T Seed, Nashita Patel, Suzanne Barr, Ruth Bell, Annette L Briley, Keith M Godfrey, Scott M Nelson, Eugene Oteng-Ntim, Sian M Robinson, Thomas A Sanders, Naveed Sattar, Jane Wardle, Lucilla Poston, Louise M Goff
BACKGROUND: Understanding dietary patterns in obese pregnant women will inform future intervention strategies to improve pregnancy outcomes and the health of the child. The aim of this study was to investigate the effect of a behavioral intervention of diet and physical activity advice on dietary patterns in obese pregnant woman participating in the UPBEAT study, and to explore associations of dietary patterns with pregnancy outcomes. METHODS: In the UPBEAT randomized controlled trial, pregnant obese women from eight UK multi-ethnic, inner-city populations were randomly assigned to receive a diet/physical activity intervention or standard antenatal care...
November 29, 2016: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/27884961/therapeutic-silencing-of-fat-specific-protein-27-improves-glycemic-control-in-mouse-models-of-obesity-and-insulin-resistance
#10
Cédric Langhi, Noemí Arias, Ananthi Rajamoorthi, Jeannine Basta, Richard G Lee, Ángel Baldán
Obesity is a component of the metabolic syndrome, mechanistically linked to diabetes, fatty liver disease, and cardiovascular disease. Proteins that regulate the metabolic fate of intracellular lipid droplets are potential therapeutic candidates to treat obesity and its related consequences. CIDEC (cell death-inducing DFFA-like effector C), also known in mice as Fsp27 (fat-specific protein 27), is a lipid droplet-associated protein that prevents lipid mobilization and promotes intracellular lipid storage. The consequences of complete loss of FSP27 on hepatic metabolism and on insulin resistance are controversial, as both healthy and deleterious lipodystrophic phenotypes have been reported in Fsp27-/- mice...
November 24, 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27884550/effects-of-changing-the-amount-and-source-of-dietary-carbohydrates-on-symptoms-and-dietary-satisfaction-over-a-1-year-period-in-subjects-with-type-2-diabetes-canadian-trial-of-carbohydrates-in-diabetes-ccd
#11
Thomas M S Wolever, Jean-Louis Chiasson, Robert G Josse, Lawrence A Leiter, Pierre Maheux, Rémi Rabasa-Lhoret, N Wilson Rodger, Edmond A Ryan
OBJECTIVES: To determine the long-term effects of changing the amount or source of dietary carbohydrate on quality of life (QOL), symptoms and dietary satisfaction in people with type 2 diabetes. METHODS: Subjects with diabetes treated by diet alone (n=162) were randomly assigned to high-carbohydrate/high-glycemic-index (HGI) diets; high-carbohydrate/low-glycemic-index (LGI) diets; or lower-carbohydrate/high-monounsaturated-fat (LC) diets for 1 year. We measured QOL at baseline and at study's end, and we measured symptoms and dietary satisfaction quarterly...
November 21, 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27881400/loss-of-ucp1-exacerbates-western-diet-induced-glycemic-dysregulation-independent-of-changes-in-body-weight-in-female-mice
#12
Nathan C Winn, Victoria J Vieira-Potter, Michelle L Gastecki, Rebecca J Welly, Rebecca J Scroggins, Terese M Zidon, T'Keaya L Gaines, Makenzie L Woodford, Natalia G Karasseva, Jill A Kanaley, Harold S Sacks, Jaume Padilla
We tested the hypothesis that female mice null for UCP1 would have increased susceptibility to Western diet-induced "whitening" of brown adipose tissue (AT) and glucose intolerance. Six-week old C57BL/6J wild-type (WT) and UCP1 knockout (UCP1(-/-)) mice, housed at 25°C, were randomized to either a control diet (10% kcal from fat) or Western diet (45% kcal from fat and 1% cholesterol) for 28 weeks. Loss of UCP1 had no effect on energy intake, energy expenditure, spontaneous physical activity, weight gain, or visceral white AT mass...
November 23, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27879355/pregnancy-outcomes-in-women-with-diabetes-lessons-learned-from-clinical-research-the-2015-norbert-freinkel-award-lecture
#13
Elisabeth R Mathiesen
Among women with diabetes, the worst pregnancy outcome is seen in the subgroup of women with diabetic nephropathy. Development of severe preeclampsia that leads to early preterm delivery is frequent. Predictors and pathophysiological mechanisms for the development of preeclampsia among women with diabetes and observational studies that support antihypertension treatment for pregnant women with microalbuminuria or diabetic nephropathy preventing preeclampsia and early preterm delivery are presented here. Obtaining and maintaining strict glycemic control before and during pregnancy is paramount to prevent preterm delivery...
December 2016: Diabetes Care
https://www.readbyqxmd.com/read/27877024/understanding-the-physical-social-and-emotional-experiences-of-people-with-uncontrolled-type-2-diabetes-a-qualitative-study
#14
Anna Berenguera, Àngels Molló-Inesta, Manel Mata-Cases, Josep Franch-Nadal, Bonaventura Bolíbar, Esther Rubinat, Dídac Mauricio
PURPOSE: The purpose of this study was to identify the perceptions, barriers, and facilitators of self-management of Type 2 diabetes mellitus (T2DM) to determine the factors to consider when developing and implementing a person-centered intervention in patients with poor glycemic control attending primary care. METHODS: This was a qualitative study conducted in 6 primary care health centers in Catalonia. Patients who had been diagnosed with T2DM and had glycated hemoglobin of 9% or more were included...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27876536/the-protective-effect-of-1alpha-25-dihydroxyvitamin-d3-and-metformin-on-liver-in-type-2-diabetic-rats
#15
REVIEW
Samah Elattar, Suzanne Estaphan, Enas A Mohamed, Ahmed Elzainy, Mary Naguib
There is an accumulating evidence suggesting an immunomodulatory role of 1α,25(OH)2D3. Altered 1α,25(OH)2D3 level may play a role in the development of T2DM and contribute to the pathogenesis of liver diseases. Our study was designed to study and compare the effect of metformin and 1α,25(OH)2D3 supplementation on liver injury in type 2 diabetic rat. Sixty male Albino rats were divided into 5 groups; group 1: control rats. the remaining rats were fed high fat diet for 2 weeks and injected with streptozotocin (35mg/kg BW, i...
November 19, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27866076/antioxidant-properties-of-tea-blunt-ros-dependent-lipogenesis-beneficial-effect-on-hepatic-steatosis-in-a-high-fat-high-sucrose-diet-nafld-obese-rat-model
#16
Laura Braud, Sylvain Battault, Grégory Meyer, Alessandro Nascimento, Sandrine Gaillard, Georges de Sousa, Roger Rahmani, Catherine Riva, Martine Armand, Jean-Michel Maixent, Cyril Reboul
Oxidative stress could trigger lipid accumulation in liver and thus hepatic steatosis. Tea is able to prevent liver disorders, but a direct link between antioxidant capacities and prevention of steatosis has not been reported yet. We aimed to investigate such relationship in a rat model of high fat-high sucrose diet (HFS)-induced obesity and to explore more deeply the mechanisms in isolated hepatocytes. Wistar rats were divided into a control group (standard diet), an HFS group (high fat-sucrose diet) and an HFS+tea group (HFS diet with ad-libitum access to tea drink)...
October 29, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27860391/mechanism-of-lipid-lowering-action-of-the-dpp-4-inhibitor-anagliptin-in-ldlr-deficient-mice
#17
Wataru Yano, Noriyuki Inoue, Shiori Ito, Takahiro Itou, Misako Yasumura, Yasunobu Yoshinaka, Sumihiko Hagita, Moritaka Goto, Takashi Nakagawa, Keisuke Inoue, Sohei Tanabe, Kohei Kaku
AIMS/INTRODUCTION: Dipeptidyl peptidase-4 (DPP-4) inhibitors are used for treatment of patients with type 2 diabetes. In addition to glycemic control, these agents showed beneficial effects on lipid metabolism in clinical trials. However, the mechanism underlying the lipid-lowering effect of DPP-4 inhibitors remains unclear. Here, we investigated the lipid-lowering efficacy of anagliptin in a hyperlipidemic animal model, and examined the mechanism of action. MATERIALS AND METHODS: Male LDLR-deficient mice were administered 0...
November 10, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27855340/systematic-review-and-meta-analysis-is-lifestyle-modification-effective-for-glycemic-control-among-adults-with-type-ii-diabetes-in-southeast-asia
#18
Zaw Wai Htoo, Wei-Wen Hsu, Richard Rosenkranz
This systematic review with meta-analysis examined whether lifestyle modification (diet and/or exercise) is effective for glycemic control in adults with type 2 diabetes in Southeast Asia. Results showed that lifestyle modification is effective in the short term (3months), but not over the longer term (6months) in this population.
October 19, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27854513/child-care-exposure-influences-childhood-adiposity-at-2-years-analysis-from-the-rolo-study
#19
Helena Scully, Goiuri Alberdi, Ricardo Segurado, Aoife McNamara, Karen Lindsay, Mary Horan, Eilis Hennessy, Eileen Gibney, Fionnuala McAuliffe
BACKGROUND: The first 2 years of life are instrumental for childhood physical development. Factors contributing to childhood obesity are difficult to determine; child care exposure is one to consider, by influencing food preference and physical activity development. OBJECTIVE: To investigate the association of child care exposure with adiposity at 2 years. METHODS: Data were collected as part of the secondary analysis of the prospective ROLO study (randomized control trial of low glycemic index diet) in Dublin, Ireland...
November 17, 2016: Childhood Obesity
https://www.readbyqxmd.com/read/27831918/17%C3%AE-estradiol-suppresses-visceral-adipogenesis-and-activates-brown-adipose-tissue-specific-gene-expression
#20
Saad Misfer Al-Qahtani, Galyna Bryzgalova, Ismael Valladolid-Acebes, Marion Korach-André, Karin Dahlman-Wright, Suad Efendić, Per-Olof Berggren, Neil Portwood
Both functional ovaries and estrogen replacement therapy (ERT) reduce the risk of type 2 diabetes (T2D). Understanding the mechanisms underlying the antidiabetic effects of 17β-estradiol (E2) may permit the development of a molecular targeting strategy for the treatment of metabolic disease. This study examines how the promotion of insulin sensitivity and weight loss by E2 treatment in high-fat-diet (HFD)-fed mice involve several anti-adipogenic processes in the visceral adipose tissue. Magnetic resonance imaging (MRI) revealed specific reductions in visceral adipose tissue volume in HFD+E2 mice, compared with HFD mice...
November 10, 2016: Hormone Molecular Biology and Clinical Investigation
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