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Whipple' Disease

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https://www.readbyqxmd.com/read/29785580/a-comprehensive-review-and-meta-analysis-of-risk-factors-for-statin-induced-myopathy
#1
REVIEW
Khoa A Nguyen, Lang Li, Deshun Lu, Aida Yazdanparast, Lei Wang, Rolf P Kreutz, Elizabeth C Whipple, Titus K Schleyer
PURPOSE: To aid prescribers in assessing a patient's risk for statin-induced myopathy (SIM), we performed a comprehensive review of currently known risk factors and calculated aggregated odds ratios for each risk factor through a meta-analysis. METHODS: This meta-analysis was done through four phases: (1) Identification of the relevant primary literature; (2) abstract screening using inclusion and exclusion criteria; (3) detailed review and data extraction; and (4) synthesis and statistical analysis...
May 22, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29769372/iglon5-mediated-neurodegeneration-is-a-differential-diagnosis-of-cns-whipple-disease
#2
Hugo Morales-Briceño, Belinda Cruse, Alessandro F Fois, Ming-Wei Lin, Jocelyn Jiang, Dev Banerjee, Ron Grunstein, Winny Varikatt, Michael Rodriguez, Claire Shepherd, Victor S C Fung
No abstract text is available yet for this article.
May 16, 2018: Neurology
https://www.readbyqxmd.com/read/29737455/current-and-future-use-of-chloroquine-and-hydroxychloroquine-in-infectious-immune-neoplastic-and-neurological-diseases-a-mini-review
#3
REVIEW
Domenico Plantone, Tatiana Koudriavtseva
The process of finding new therapeutic indications for currently used drugs, defined as 'repurposing', is receiving growing attention. Chloroquine and hydroxychloroquine, with an original indication to prevent or cure malaria, have been successfully used to treat several infectious (HIV, Q fever, Whipple's disease, fungal infections), rheumatological (systemic lupus erythematosus, antiphospholipid antibody syndrome, rheumatoid arthritis, Sjögren's syndrome), and other immunological diseases. Indeed, they have anti-inflammatory, immunomodulating, anti-infective, antithrombotic, and metabolic effects...
May 8, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29729226/eus-guided-hepaticoenterostomy-as-a-portal-to-allow-definitive-antegrade-treatment-of-benign-biliary-diseases-in-patients-with-surgically-altered-anatomy
#4
Theodore W James, Y Claire Fan, Todd H Baron
BACKGROUND & AIMS: EUS-guided hepaticoenterostomy (EUS-HE) is usually reserved for palliation of malignant biliary obstruction after failed endoscopic retrograde cholangiography (ERC) or inaccessible biliary tree in surgically altered anatomy (SAA). We describe outcome of EUS-HE and antegrade therapy for benign biliary disease in patients with SAA. METHODS: Retrospective review of 20 consecutive patients with surgically altered anatomy and benign biliary obstruction who underwent EUS-HE performed by one endoscopist at a tertiary center over a three-year period...
May 2, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29725938/gamma-delta-t-cell-expansion-in-whipple-s-disease-with-muscular-granulomatous-vasculitis
#5
Didier Brönnimann, Marie-Anne Vandenhende, Jean-François Viallard
Whipple's disease usually presents as chronic joint pain followed by digestive manifestations. However, many different presentations have been described in the literature. We report here the first proven case of muscular vasculitis related to Whipple's disease, associated with an expansion of circulating activated γδ T lymphocytes.
May 3, 2018: Infection
https://www.readbyqxmd.com/read/29707758/whipple-disease-presenting-as-cystic-brain-tumor-case-report-and-review-of-the-literature
#6
Mohamed Kilani, Leila Njim, Atef Ben Nsir, Mohamed Nejib Hattab
Although neurological features are commonly encountered in Whipple"s disease (WD), presentation with purely neurological patterns is uncommon. Exclusive confinement to the central nervous system (CNS) is extremely rare. In these cases, the development of an isolated cerebral mass is exceptional. In the present paper, the authors describe a case of a 68-year-old man who presented with partial seizures. The neurological examination was normal. The imaging showed a cystic lesion. This tumor-like lesion was removed by performing frontal craniotomy...
2018: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29671537/chronic-pancreatitis-diagnosis-and-treatment
#7
Kathleen Barry
Chronic pancreatitis is an irreversible and progressive disorder of the pancreas characterized by inflammation, fibrosis, and scarring. Exocrine and endocrine functions are lost, often leading to chronic pain. The etiology is multifactorial, although alcoholism is the most significant risk factor in adults. The average age at diagnosis is 35 to 55 years. If chronic pancreatitis is suspected, contrast-enhanced computed tomography is the best imaging modality for diagnosis. Computed tomography may be inconclusive in early stages of the disease, so other modalities such as magnetic resonance imaging, magnetic resonance cholangiopancreatography, or endoscopic ultrasonography with or without biopsy may be used...
March 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29667578/back-from-the-brink-of-obscurity
#8
Donald C Vinh
A mutation in a transcription factor makes people susceptible to Tropheryma whipplei , the bacterium that causes a rare condition called Whipple's disease.
April 18, 2018: ELife
https://www.readbyqxmd.com/read/29624648/cns-langerhans-cell-histiocytosis-common-hematopoietic-origin-for-lch-associated-neurodegeneration-and-mass-lesions
#9
Kenneth L McClain, Jennifer Picarsic, Rikhia Chakraborty, Daniel Zinn, Howard Lin, Harshal Abhyankar, Brooks Scull, Albert Shih, Karen Phaik Har Lim, Olive Eckstein, Joseph Lubega, Tricia L Peters, Walter Olea, Thomas Burke, Nabil Ahmed, M John Hicks, Brandon Tran, Jeremy Jones, Robert Dauser, Michael Jeng, Robert Baiocchi, Deborah Schiff, Stanton Goldman, Kenneth M Heym, Harry Wilson, Benjamin Carcamo, Ashish Kumar, Carlos Rodriguez-Galindo, Nicholas S Whipple, Patrick Campbell, Geoffrey Murdoch, Julia Kofler, Simon Heales, Marian Malone, Randy Woltjer, Joseph F Quinn, Paul Orchard, Michael C Kruer, Ronald Jaffe, Markus G Manz, Sergio A Lira, D Williams Parsons, Miriam Merad, Tsz-Kwong Man, Carl E Allen
BACKGROUND: Central nervous system Langerhans cell histiocytosis (CNS-LCH) brain involvement may include mass lesions and/or a neurodegenerative disease (LCH-ND) of unknown etiology. The goal of this study was to define the mechanisms of pathogenesis that drive CNS-LCH. METHODS: Cerebrospinal fluid (CSF) biomarkers including CSF proteins and extracellular BRAFV600E DNA were analyzed in CSF from patients with CNS-LCH lesions compared with patients with brain tumors and other neurodegenerative conditions...
April 6, 2018: Cancer
https://www.readbyqxmd.com/read/29623746/synchronous-pancreatic-serous-cystic-neoplasm-and-duodenal-neuroendocrine-tumor-case-report-and-review-of-the-literature
#10
Ann Brinch Madelung, Sönke Detlefsen
Simultaneous presence of pancreatic serous cystic neoplasms and neuroendocrine neoplasms is rare. We present a case with the incidental finding of a duodenal neuroendocrine tumor (NET) with 2 lymph node metastases in a Whipple resection specimen performed to remove a pancreatic cystic neoplasm that postoperatively turned out to represent a serous cystic neoplasm (SCN). The patient was a 75-year-old female. She presented with loss of appetite and weight. Preoperative contrast-enhanced computed tomography scan of the abdomen showed a multicystic lesion in the head of pancreas...
April 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29589453/-multidisciplinary-approach-to-surgical-disorders-of-the-pancreas-in-children
#11
J Šnajdauf, M Rygl, O Petrů, B Frýbová, J Náhlovský, V Mixa, R Keil, J Bronský, M Kynčl, R Kodet
INTRODUCTION: Surgical diseases of the pancreas in children are not common and may be associated with significant morbidity and potential mortality. A multidisciplinary approach is essential for correct diagnosis, surgical strategy and postoperative as well as follow-up care. METHOD: Retrospective analysis of patients operated on due to a pathological lesion of the pancreas focused on diagnostics, operating procedures, postoperative complications, and long-term results...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/29579249/a-misleading-diagnosis-of-granulomatosis-with-polyangiitis-disguising-whipple-s-disease
#12
Francesco Peyronel, Paride Fenaroli, Giuseppe D Benigno, Alessandro A Palumbo, Eugenia M Martella, Federico Biagi, Augusto Vaglio
No abstract text is available yet for this article.
March 20, 2018: Rheumatology
https://www.readbyqxmd.com/read/29572616/tropheryma-whipplei-infection-whipple-disease-in-the-usa
#13
Isabel A Hujoel, David H Johnson, Benjamin Lebwohl, Daniel Leffler, Sonia Kupfer, Tsung-Teh Wu, Joseph A Murray, Alberto Rubio-Tapia
BACKGROUND: Whipple disease (WD) is an infection caused by the bacterium Tropheryma whipplei (TW). Few cases have been reported in the USA. AIMS: To report on the demographics, clinical manifestations, diagnostic findings, treatment, and outcomes of TW infection. METHODS: Cases of TW infection diagnosed from 1995 to 2010 were identified in three US referral centers and from 1995 to 2015 in one. Definite classic WD was defined by positive periodic acid-Schiff (PAS) staining and probable WD by specific positive TW polymerase chain reaction (PCR) of intestinal specimens...
March 23, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29537367/irf4-haploinsufficiency-in-a-family-with-whipple-s-disease
#14
Antoine Guérin, Gaspard Kerner, Nico Marr, Janet G Markle, Florence Fenollar, Natalie Wong, Sabri Boughorbel, Danielle T Avery, Cindy S Ma, Salim Bougarn, Matthieu Bouaziz, Vivien Béziat, Erika Della Mina, Carmen Oleaga-Quintas, Tomi Lazarov, Lisa Worley, Tina Nguyen, Etienne Patin, Caroline Deswarte, Rubén Martinez-Barricarte, Soraya Boucherit, Xavier Ayral, Sophie Edouard, Stéphanie Boisson-Dupuis, Vimel Rattina, Benedetta Bigio, Guillaume Vogt, Frédéric Geissmann, Lluis Quintana-Murci, Damien Chaussabel, Stuart G Tangye, Didier Raoult, Laurent Abel, Jacinta Bustamante, Jean-Laurent Casanova
Most humans are exposed to Tropheryma whipplei (Tw). Whipple's disease (WD) strikes only a small minority of individuals infected with Tw (<0.01%), whereas asymptomatic chronic carriage is more common (<25%). We studied a multiplex kindred, containing four WD patients and five healthy Tw chronic carriers. We hypothesized that WD displays autosomal dominant (AD) inheritance, with age-dependent incomplete penetrance. We identified a single very rare non-synonymous mutation in the four patients: the private R98W variant of IRF4, a transcription factor involved in immunity...
March 14, 2018: ELife
https://www.readbyqxmd.com/read/29507019/whipple-s-disease-a-rare-case-of-malabsorption
#15
Ana Lopes, Ana Filipa Santos, Maria Joana Alvarenga, Alberto Mello E Silva
Whipple's disease is a chronic, rare, multisystemic, infectious entity, described for the first time in 1907. Its aetiological agent is the Gram-negative rod, Tropheryma whipplei, which was isolated for the first time in 2001 from a cardiac valve of a patient with endocarditis. We present the case of a 71-year-old man, who came into the emergency room complaining of anorexia, weakness, abdominal pain and diarrhoea with haematochezia and presented disseminated palpable purpuric lesions, predominantly in the lower limbs...
March 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29463197/cephalic-pancreaticoduodenectomy-with-preservation-of-a-right-coronary-artery-bypass-graft-using-the-right-gastro-epiploic-artery-a-case-report
#16
K Homsy, J-L Paquay, H Farghadani
INTRODUCTION: Pancreatic cancer is a rare disease with a high mortality rate, for which complete surgical resection, when possible, is the preferred therapeutic. Pancreaticoduodenectomy represents the surgical technique of choice. Abdominal surgeons can be faced with the challenge of patients with a history of coronary artery bypass graft in which the right gastro-epiploic artery is used. CASE REPORT: We report the case of a patient with an adenocarcinoma of the pancreatic head, stage IIA, having previously undergone a triple coronary artery bypass, one of which being a right gastro-epiploic graft...
February 20, 2018: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29452860/pancreaticoduodenectomy-in-the-surgical-management-of-primary-retroperitoneal-sarcoma
#17
William W Tseng, Denice D Tsao-Wei, Dario Callegaro, Giovanni Grignani, Lorenzo D'Ambrosio, Sylvie Bonvalot, Cecilia G Ethun, Kenneth Cardona, John T Mullen, Robert J Canter, John E Mullinax, Ricardo J Gonzalez, Frits van Coevorden, Markus Albertsmeier, Kiran K Dhanireddy, Salvatore L Renne, Alessandro Gronchi
BACKGROUND: In retroperitoneal sarcoma (RPS), the optimal extent of resection must balance adequate disease control with potential for morbidity. We sought to study the frequency and outcomes after a Whipple procedure or pancreaticoduodenectomy (PD) in patients undergoing resection for primary RPS. METHODS: Participating referral centers within the Trans-Atlantic Retroperitoneal Sarcoma Working Group provided retrospective data from January 2007 to December 2016 for patients with primary RPS who underwent PD along with the total number of consecutive resections done during the same time period...
February 5, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29452626/translation-of-an-evidence-based-therapeutic-exercise-program-for-patients-with-peripheral-artery-disease
#18
Dereck L Salisbury, Mary O Whipple, Marsha Burt, Rebecca J L Brown, Alan Hirsch, Christopher Foley, Diane Treat-Jacobson
The purpose of this study was to implement and evaluate quality outcomes including referral, enrollment, and completion rates of a new peripheral artery disease (PAD)-specific supervised exercise therapy (SET) program within a preexisting clinical exercise wellness program and to evaluate the clinical effectiveness and patient-centered outcomes derived from 12 weeks of PAD-specific SET. Recruited participants completed an individualized, minimally supervised, PAD-specific SET program based on the AHA-ACC guidelines...
March 2018: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/29434152/whipple-s-disease-a-case-report-with-long-term-endoscopic-follow-up
#19
Hiroaki Saito, Junji Shiode, Shogen Ohya, Atsushi Yao, Shunsuke Saito, Masakuni Fujii, Mamoru Itoh, Shuhei Ishiyama, Akiko Fujiwara, Junichiro Nasu, Masao Yoshioka, Kazuhide Yamamoto
A 72-year-old man presented with anorexia and 15-kg weight loss over 3 years. Endoscopy revealed yellow, shaggy mucosa alternating with erythematous, eroded mucosa in the duodenum. Biopsy specimens showed massive infiltration of periodic acid-Schiff-positive macrophages in the lamina propria, consistent with Whipple's disease. The patient was treated with intravenous ceftriaxone for four weeks, followed by oral trimethoprim-sulfamethoxazole. His condition improved, and he gradually gained weight. Although the endoscopic findings improved with continuous trimethoprim-sulfamethoxazole administration, macrophage infiltration of the duodenal mucosa persisted...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29289973/neurological-and-neuropsychological-complications-in-the-course-of-chronic-whipple-s-disease-case-report
#20
Izabela Dymon, Justyna Tabaka-Pradela, Katarzyna Anna Knast, Dominika Dudek, Monika Rudzińska
INTRODUCTION: Whipple's disease (WD) is a chronic, multisystemic infectious disease caused by Gram-positive bacillus Tropheryma whipplei (T.w.). Its common symptoms arise in the digestive system, however, during the infection the CNS (Central Nervous System) may also be affected. AIM: The aim of this work is to present a case report of a patient diagnosed with Whipple's disease with dominant neuropsychological and behavioural complications in the late phase. CONCLUSIONS: Whipple's disease is a rare disease with possible neurological and neuropsychiatric complications...
October 29, 2017: Psychiatria Polska
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