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https://www.readbyqxmd.com/read/28448848/transmissible-gastroenteritis-virus-infection-induces-nf-%C3%AE%C2%BAb-activation-through-rlr-mediated-signaling
#1
Zhen Ding, Kang An, Lilan Xie, Wei Wu, Ruoxi Zhang, Dang Wang, Ying Fang, Huanchun Chen, Shaobo Xiao, Liurong Fang
Transmissible gastroenteritis virus (TGEV) is a porcine enteric coronavirus which causes lethal severe watery diarrhea in piglets. The pathogenesis of TGEV is strongly associated with inflammation. In this study, we found that TGEV infection activates transcription factors NF-κB, IRF3 and AP-1 in a time- and dose-dependent manner in porcine kidney cells. Treatment with the NF-κB-specific inhibitor BAY11-7082 significantly decreased TGEV-induced proinflammatory cytokine production, but did not affect virus replication...
April 24, 2017: Virology
https://www.readbyqxmd.com/read/28447329/immune-response-against-salmonella-enteritidis-is-unsettled-by-hiv-infection
#2
Maira Costa Cacemiro, Milena Sobral Espíndola, Leonardo Judson Galvão-Lima, Luana Silva Soares, Caroline Fontanari, Marco Aurélio Prata, Fábio Campioni, Juliana Pfrimer Falcão, Valdes Roberto Bollela, Fabiani Gai Frantz
The human immunodeficiency virus (HIV) is responsible for more than 2 million new infections per year and opportunistic infections such as Salmonella spp. Gastroenteritis is an important cause of mortality and morbidity in developing countries. Monocytes and macrophages play a critical role in the innate immune response against bacterial infections. However during HIV infection the virus can infect these cells and although they are more resistant to the cytopathic effects, they represent an important viral reservoir in these patients...
April 27, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28446571/a-core-genome-multi-locus-sequence-typing-scheme-for-stable-comparative-analyses-of-campylobacter-jejuni-and-c-coli-human-disease-isolates
#3
Alison J Cody, James E Bray, Keith A Jolley, Noel D McCarthy, C J Maiden Martin
Human campylobacteriosis, caused by Campylobacter jejuni and C. coli, remains a leading cause of bacterial gastroenteritis in many countries, but the epidemiology of campylobacteriosis outbreaks remains poorly defined, largely due to limitations in the resolution and comparability of isolate characterisation methods. Whole genome sequencing (WGS) data enables the improvement of sequence-based typing approaches, such as multi locus sequence typing (MLST), by substantially increasing the number of loci examined...
April 26, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28446379/group-a-rotavirus-genotypes-in-hospital-acquired-gastroenteritis-in-italy-2012-14
#4
G Ianiro, R Delogu, L Fiore, M Monini, F M Ruggeri
BACKGROUND: Group A rotaviruses (RVA) are the leading cause of acute gastroenteritis (AGE) in young (aged <5 years) children, causing ∼250,000 deaths worldwide, mostly in developing countries. Differences on nucleotide sequences of VP7 (G-type) and VP4 (P-type) genes are the basis for the binary RVA nomenclature. Although at least 32 G-types and 47 P-types of rotavirus are presently known, most RVA infections in humans worldwide are related to five major G/P combinations: G1P[8], G2P[4], G3P[8], G4P[8], and G9P[8]...
April 8, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28445504/correction-gastroenteritis-therapies-in-developed-countries-systematic-review-and-meta-analysis
#5
Stephen B Freedman, Dion Pasichnyk, Karen J L Black, Eleanor Fitzpatrick, Serge Gouin, Andrea Milne, Lisa Hartling
[This corrects the article DOI: 10.1371/journal.pone.0128754.].
2017: PloS One
https://www.readbyqxmd.com/read/28444305/dissemination-of-gastroenteric-viruses-in-the-production-of-lettuce-in-developing-countries-a-public-health-concern
#6
Lucia M C Werneck, Carmen B Vieira, Tulio M Fumian, Thalles Borges Caetano, Jarbas Emílio Dos Santos, Fernando César Ferreira, Marcia Maria Pimenta, Marize P Miagostovich
Investigation of major viruses responsible for acute viral gastroenteritis, such as norovirus (NoV), rotavirus species A (RVA) and human adenovirus (HAdV), was conducted in the mountainous region of the state of Rio de Janeiro in a lettuce-producing area. Irrigation water and lettuce samples were collected at different production stages. Viruses were concentrated using an adsorption-elution method and detected by quantitative polymerase chain reaction (qPCR). We detected HAdV in all collection points, although no virus infectivity was shown...
April 21, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28444299/environmental-factors-associated-with-disease-flare-in-juvenile-and-adult-dermatomyositis
#7
Gulnara Mamyrova, Lisa G Rider, Alison Ehrlich, Olcay Jones, Lauren M Pachman, Robert Nickeson, Lisa G Criscone-Schreiber, Lawrence K Jung, Frederick W Miller, James D Katz
Objective.: The aim was to assess environmental factors associated with disease flare in juvenile and adult dermatomyositis (DM). Methods.: An online survey of DM patients from the USA and Canada examined smoking, sun exposure, infections, medications, vaccines, stressful life events and physical activity during the 6 months before flares, or in the past 6 months in patients without flares. Differences were evaluated by χ 2 and Fisher's exact tests, and significant univariable results were examined in multivariable logistic regression...
April 21, 2017: Rheumatology
https://www.readbyqxmd.com/read/28444025/risk-of-misinterpretation-of-trends-in-hospital-admissions-for-primary-care-sensitive-conditions-in-local-contexts-itabora%C3%A3-rio-de-janeiro-state-brazil-2006-2011
#8
Janaina Furtado Botelho, Margareth Crisóstomo Portela
The study's objectives were to describe hospital admissions for primary care sensitive conditions (PCSCs) among residents of Itaboraí, a municipality in Rio de Janeiro State, Brazil, with a high rate of such admissions, to identify associated factors, and to explore the impact from closing a hospital. The ultimate aim was to contribute to the debate on the indicator's indiscriminate use for inferences on the expansion and quality of primary care. The study was based on data from the Hospital Information System of the Brazilian Unified National Health System...
April 20, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28443591/clinical-findings-of-pediatric-hiv-infection-at-a-tertiary-center-in-turkey
#9
Murat Sütçü, Manolya Acar, Hacer Aktürk, Selda Hançerli Torun, Hayati Beka, Ali Ağaçfidan, Nuran Salman, Ayper Somer
BACKGROUND: Pediatric HIV infection is different from adult type of disease in many ways including transmission routes, clinical findings and treatment strategies. AIMS: Our aim was to evaluate clinical data of our pediatric HIV patients. STUDY DESIGN: Retrospective cross-sectional study. METHODS: The charts of 22 pediatric patients diagnosed with HIV infection in our clinic during a 14 year period through 2001-2015 were retrospectively analyzed...
April 6, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28443229/emergence-of-norovirus-gii-17-associated-outbreak-and-sporadic-cases-in-korea-from-2014-to-2015
#10
Sunyoung Jung, Bo-Mi Hwang, HyunJu Jung, GyungTae Chung, Cheon-Kwon Yoo, Deog-Yong Lee
Human norovirus are major causative agent of nonbacterial acute gastroenteritis. In general, genogroup (G) II.4 is the most prominent major genotype that circulate in human population and the environment. However, a shift in genotypic trends was observed in Korea in December 2014. In this study, we investigated the trend of norovirus genotype in detail using the database of Acute Diarrhea Laboratory Surveillance (K-EnterNet) in Korea. GII.17 has since become a major contributor to outbreaks of norovirus-related infections and sporadic cases in Korea, although the reason for this shift remain unknown...
February 2017: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/28443081/helicobacter-pullorum-an-emerging-zoonotic-pathogen
#11
REVIEW
Sundus Javed, Farzana Gul, Kashaf Javed, Habib Bokhari
Helicobacter pullorum (H.pullorum) commonly colonizes the gastrointestinal tract of poultry causing gastroenteritis. The bacterium may be transmitted to humans through contaminated meat where it has been associated with colitis and hepatitis. Despite the high prevalence of H. pullorum observed in poultry, little is known about the mechanisms by which this bacterium establishes infection in host and its virulence determinants. In this article we aim to provide an overview of this emerging zoonotic pathogen; its general characteristics, hosts, prevalence, and transmission as well as its pathogenic potential...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28442437/characterization-of-enterotoxigenic-escherichia-coli-strains-isolated-from-the-massive-multi-pathogen-gastroenteritis-outbreak-in-the-antofagasta-region-following-the-chilean-earthquake-2010
#12
David Montero, Maricel Vidal, Mirka Pardo, Alexia Torres, Eduardo Kruger, Mauricio Farfán, Miguel O'Ryan, Qingwei Luo, James Fleckenstein, Felipe Del Canto, Roberto Vidal
In March 2010, a massive outbreak of gastroenteritis started in the region of Antofagasta (northern Chile). The outbreak was mainly attributed to Norovirus genogroup II although ETEC strains were also isolated with high frequency from clinical samples. We review this outbreak and determined that ETEC was an underestimated etiologic agent.
April 22, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28442435/effectiveness-of-rotavirus-pentavalent-vaccine-under-a-universal-immunization-program-in-israel-2011-2015-a-case-control-study
#13
Khitam Muhsen, Emilia Anis, Uri Rubinstein, Eias Kassem, Sophy Goren, Lester M Shulman, Moshe Ephros, Daniel Cohen
OBJECTIVES: The use of rotavirus pentavalent vaccine (RotaTeq) as a sole vaccine within rotavirus universal immunization programs remains limited. We examined the effectiveness of RotaTeq in preventing rotavirus gastroenteritis (RVGE) hospitalization in Israel, after the introduction of universal immunization against the disease. METHODS: A test-negative case-control study included age-eligible children for universal RotaTeq immunization (ages 2-59 months, born in 2011-2015)...
April 22, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28441094/background-rates-of-disease-in-latin-american-children-from-a-rotavirus-vaccine-study
#14
Marc Baay, Kaatje Bollaerts, Claudio Struchiner, Thomas Verstraeten
BACKGROUND: Knowledge of background rates of adverse events is crucial to assess vaccine safety concerns. We used data from a rotavirus vaccine study (Ruiz-Palacios et al., NEJM, 2006) including 63,225 infants from 11 Latin American countries to investigate reporting rates of serious adverse events (SAEs) among these infants, and describe rates by country, gender, age, and season. METHODS: For this randomized, double-blind, placebo-controlled, phase 3 trial, investigators from Argentina, Brazil, Chile, Colombia, Dominican Republic, Honduras, Mexico, Nicaragua, Panama, Peru, and Venezuela recruited 6-to-13-week-old healthy infants...
April 25, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28440714/hypereosinophilic-syndrome-endomyocardial-biopsy-versus-echocardiography-to-diagnose-cardiac-involvement
#15
Joseph H Butterfield, Garvan C Kane, Catherine R Weiler
OBJECTIVE: To compare echocardiograms and endomyocardial biopsies to diagnose cardiac involvement in hypereosinophilic syndrome. METHODS: We examined the agreement between echocardiography and endomyocardial biopsies to detect cardiac involvement in hypereosinophilic syndrome by reviewing cases identified as hypereosinophilia or hypereosinophilic syndrome in Mayo Clinic databases from January 1978 through June 2009. Single-organ cases of eosinophilia such as eosinophilic fasciitis and eosinophilic gastroenteritis were excluded...
April 25, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28440688/simultaneous-identification-of-campylobacter-jejuni-campylobacter-coli-and-campylobacter-lari-with-smartcycler-based-multiplex-quantitative-polymerase-chain-reaction
#16
Kun C Liu, Karen C Jinneman, Jason Neal-McKinney, Wen-Hsin Wu, Daniel H Rice
BACKGROUND: Consumption of Campylobacter contaminated food or water is a leading cause of human acute gastroenteritis. Campylobacter jejuni, Campylobacter coli, and Campylobacter lari account for over 95% of total Campylobacter infections. A multiplex quantitative polymerase chain reaction (qPCR) for simultaneous identification of C. jejuni, C. coli, and C. lari was developed for use with the SmartCycler II system. MATERIALS AND METHODS: We evaluated and combined previously described primers and probes for Campylobacter detection, designed a new internal amplification control, and optimized the multiplex qPCR for the detection of C...
April 25, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28438670/epidemiological-features-and-genetic-characterization-of-virus-strains-in-rotavirus-associated-gastroenteritis-in-children-of-odisha-in-eastern-india
#17
Eileena Mohanty, Bhagirathi Dwibedi, S K Kar, A S Acharya
We have studied the clinical characteristics, severity and seasonality of rotavirus infection and prevalent genotypes in 652 non-rota vaccinated children in Odisha in eastern India. P genotypes were analysed for their association with host blood group antigens. P type of the virus is determined by the VP8* gene, and specific recognition of A - type of Histo - blood group antigen by P[14]VP8* has been reported. VP4, VP7 and VP6 genes of commonly identified G1P[8] strain were compared with genes of the same strain isolated from other parts of India, elsewhere and strains used for Rotarix and Rotateq vaccines...
April 21, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28438630/identification-of-anti-viral-activity-of-the-cardenolides-na-k-atpase-inhibitors-against-porcine-transmissible-gastroenteritis-virus
#18
Cheng-Wei Yang, Hsin-Yu Chang, Hsing-Yu Hsu, Yue-Zhi Lee, Hsun-Shuo Chang, Ih-Sheng Chen, Shiow-Ju Lee
A series of naturally occurring cardenolides that exhibit potent anti-transmissible gastroenteritis virus (TGEV) activity in swine testicular (ST) cells has been identified. In an immunofluorescence assay, these cardenolides were found to diminish the expressions of TGEV nucleocapsid and spike protein, which was used as an indication for viral replication; block TGEV infection induced apoptosis and cytopathic effects; and impart the same trend of inhibitory activity against Na(+)/K(+)-ATPase as for anti-TGEV activity...
April 21, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28438623/ezh2-overexpression-in-primary-gastrointestinal-diffuse-large-b-cell-lymphoma-and-its-association-with-the-clinicopathological-features
#19
Yang Liu, Kangjie Yu, Mingyang Li, Kaixuan Zeng, Jie Wei, Xia Li, Yixiong Liu, Danhui Zhao, Linni Fan, Zhou Yu, Yingmei Wang, Zengshan Li, Wei Zhang, Qingxian Bai, Qingguo Yan, Ying Guo, Zhe Wang, Shuangping Guo
Gastrointestinal diffuse large B cell lymphoma (GI DLBCL) is the most common gastrointestinal lymphoma, Enhancer of zeste homolog 2 (EZH2) have been implicated in the pathogenesis of several cancers. However, EZH2 has not been studied in GI DLBCL. Thus, we investigated EZH2 expression and EZH2 Y641 mutation in 100 GI DLBCL specimens by immunohistochemistry and sequencing. In addition, trimethylated H3K27 (H3K27me3), BCL2, c-MYC, and Ki-67 expression and Helicobacter pylori infection were detected, and BCL2 and c-MYC gene translocation were assessed...
April 21, 2017: Human Pathology
https://www.readbyqxmd.com/read/28433796/genetic-diversity-and-virulence-genes-of-salmonella-enterica-subspecies-enterica-serotype-enteritidis-isolated-from-meats-and-eggs
#20
Fatemeh Fardsanei, Mohammad Mehdi Soltan Dallal, Masoumeh Douraghi, Taghi Zahraei Salehi, Mahmood Mahmoodi, Hamed Memariani, Farhad Nikkhahi
Salmonella enterica subspecies enterica serotype Enteritidis (S. Enteritidis) is one of the leading causes of food-borne gastroenteritis associated with the consumption of contaminated food products of animal origin. Little is known about the genetic diversity and virulence content of S. Enteritidis isolated from poultry meats and eggs in Iran. A total of 34 S. Enteritidis strains were collected from different food sources of animal origin in Tehran from May 2015 to July 2016. All of the S. Enteritidis strains were serotyped, antimicrobial susceptibility tested, and characterized for virulence genes...
April 19, 2017: Microbial Pathogenesis
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