keyword
MENU ▼
Read by QxMD icon Read
search

Gastroenteric

keyword
https://www.readbyqxmd.com/read/29791992/role-of-the-duodenum-in-the-pathogenesis-of-functional-dyspepsia-a-paradigm-shift
#1
REVIEW
Hye-Kyung Jung, Nicholas J Talley
Functional dyspepsia (FD) is a common disorder characterized by chronic epigastric pain or burning, or bothersome postprandial fullness or early satiation, without a definitive organic cause. The pathogenesis of FD is likely heterogeneous. Classically, motor disorders, visceral hypersensitivity, and brain-gut interactions have been implicated in the pathophysiology of FD, but recently an important role for chronic low-grade inflammation and post-infectious gastroenteritis in FD has been reported and confirmed...
May 23, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29790933/the-impact-of-rotavirus-vaccines-on-genotype-diversity-a-comprehensive-analysis-of-2-decades-of-australian-surveillance-data
#2
Susie Roczo-Farkas, Carl D Kirkwood, Daniel Cowley, Graeme L Barnes, Ruth F Bishop, Nada Bogdanovic-Sakran, Karen Boniface, Celeste M Donato, Julie E Bines
Background: Introduction of rotavirus vaccines into national immunization programs (NIPs) could result in strain selection due to vaccine-induced selective pressure. This study describes the distribution and diversity of rotavirus genotypes before and after rotavirus vaccine introduction into the Australian NIP. State-based vaccine selection facilitated a unique comparison of diversity in RotaTeq and Rotarix vaccine states. Methods: From 1995 to 2015, the Australian Rotavirus Surveillance Program conducted genotypic analysis on 13051 rotavirus-positive samples from children <5 years of age, hospitalized with acute gastroenteritis...
May 22, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29790924/typhoidal-salmonella-serovars-ecological-opportunity-and-the-evolution-of-a-new-pathovar
#3
Hirotaka Hiyoshi, Connor R Tiffany, Denise N Bronner, Andreas J Bäumler
Typhoid and paratyphoid fever are severe systemic infections caused by human-adapted typhoidal Salmonella serovars that are indistinguishable in their clinical presentation, but differ from human gastroenteritis caused by zoonotic non-typhoidal Salmonella serovars. Typhoidal Salmonella serovars evolved from ancestral gastrointestinal pathogens through genetic changes that supported a change in pathogen ecology. Typhoidal Salmonella serovars share virulence properties that were acquired through convergent evolution and therefore this group is not defined by the presence of shared virulence genes that are absent from non-typhoidal Salmonella serovars...
May 21, 2018: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/29788854/-myocardial-clefts-incidental-findings-in-parainfectious-myocarditis
#4
Florian Berger, Christopher Hansi, Tilo Niemann
Myocardial Clefts - Incidental Findings in Parainfectious Myocarditis Abstract. We report a 23-year-old woman with parainfectious myocarditis due to gastroenteritis. A transthoracic echocardio-graphy revealed a recess in the left inferobasal ventricle. For further investigation, cardiac magnetic resonance imaging was initiated, which revealed a myocardial cleft, a harmless structural variation of the heart. Cardiac magnetic resonance is a non-invasive imaging technique with a high spatial and temporal resolution that enables a precise depiction of the cardiac anatomy and therefore allows for a differentiation between normal and pathological structural variations of the heart...
2018: Praxis
https://www.readbyqxmd.com/read/29788403/evaluating-previous-antibiotic-use-as-a-risk-factor-for-acute-gastroenteritis-among-children-in-davidson-county-tennessee-2014-2015
#5
Jonathan M Kolsin, Benjamin A Lopman, Daniel C Payne, Mary E Wikswo, John R Dunn, Natasha B Halasa, Aron J Hall
Background: Epidemiologic studies that evaluate the relationship between previous antibiotic use and acute gastroenteritis (AGE) in the pediatric population are currently lacking. Methods: We analyzed inpatient and outpatient children with AGE and healthy controls from Vanderbilt University Medical Center between December 1, 2014, and November 30, 2015. The following 4 outcome groups were defined: overall AGE, norovirus-associated AGE, rotavirus-associated AGE, and nonnorovirus/nonrotavirus AGE...
May 19, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29785632/virulence-factors-in-salmonella-typhimurium-the-sagacity-of-a-bacterium
#6
REVIEW
Anamaria M P Dos Santos, Rafaela G Ferrari, Carlos A Conte-Junior
Currently, Salmonella enterica Typhimurium (ST) is responsible for most cases of food poisoning in several countries. It is characterized as a non-specific zoonotic bacterium that can infect both humans and animals and although most of the infections caused by this microorganism cause only a self-limiting gastroenteritis, some ST strains have been shown to be invasive, crossing the intestinal wall and reaching the systemic circulation. This unusual pathogenicity ability is closely related to ST virulence factors...
May 21, 2018: Current Microbiology
https://www.readbyqxmd.com/read/29784471/rotavirus-gastroenteritis-surveillance-in-azerbaijan-2011-2016
#7
Nazifa Mursalova, Nazim Shugayev, Javahir Suleymanova, Danni S Daniels, Annemarie Wasley, Adam L Cohen, Negar Aliabadi
INTRODUCTION: Rotavirus is a leading cause of acute gastroenteritis and mortality among children worldwide but data describing rotavirus disease in Azerbaijan are lacking. This analysis describes the rotavirus disease burden in Baku, the largest city in Azerbaijan. METHODS: We conducted active, prospective, sentinel hospital surveillance with laboratory confirmation for rotavirus among children under 5 years of age hospitalized at a large pediatric hospital in Baku during 2011-2016...
May 18, 2018: Vaccine
https://www.readbyqxmd.com/read/29784467/epidemiology-of-acute-diarrhea-caused-by-rotavirus-in-sentinel-surveillance-sites-of-vietnam-2012-2015
#8
Dang Thi Thanh Huyen, Duong Thi Hong, Nguyen Thanh Trung, Tran Thi Nguyen Hoa, Nguyen Kieu Oanh, Ho Vinh Thang, Nguyen Thi Thanh Thao, Do Manh Hung, Makiko Iijima, Kimberley Fox, Varja Grabovac, James Heffelfinger, Nyambat Batmunkh, Dang Duc Anh
A prospective, multicentre study was conducted in four sentinel surveillance hospitals to assess the trend and epidemiology of acute diarrhea caused by Rotavirus in Vietnam. During the period 2012-2015, a total 8,889 children under 5 years of age were enrolled in the surveillance, and 8689 stool samples were collected. Of these cases, Rotavirus was most common pathogen 46.7% (4054 cases); in which 26.6% (1117) rotavirus-positive stool samples were evaluated to identify genotypes. The proportion of rotavirus positive specimens decreased annually from 54...
May 18, 2018: Vaccine
https://www.readbyqxmd.com/read/29783653/avian-influenza-virus-subtype-h9n2-affects-intestinal-microbiota-barrier-structure-injury-and-inflammatory-intestinal-disease-in-the-chicken-ileum
#9
Hongxin Li, Xiaolin Liu, Feiyang Chen, Kejing Zuo, Che Wu, Yiming Yan, Weiguo Chen, Wencheng Lin, Qingmei Xie
Avian influenza virus subtype H9N2 (H9N2 AIV) has caused significant losses to the poultry industry due to the high mortality associated with secondary infections attributable to E. coli . This study tries to address the underlying secondary mechanisms after H9N2 AIV infection. Initially, nine day-old specific pathogen-free chickens were assigned to control (uninfected) and H9N2-infected groups, respectively. Using Illumina sequencing, histological examination, and quantitative real-time PCR, it was found that H9N2 AIV caused intestinal microbiota disorder, injury, and inflammatory damage to the intestinal mucosa...
May 18, 2018: Viruses
https://www.readbyqxmd.com/read/29781755/more-robust-gut-immune-responses-induced-by-combining-intranasal-and-sublingual-routes-for-prime-boost-immunization
#10
Hye Suk Hwang, Sao Puth, Wenzhi Tan, Vivek Verma, Kwangjoon Jeong, Shee Eun Lee, Joon Haeng Rhee
Norovirus causes acute and debilitating gastroenteritis, characterized by vomiting and diarrhea. We recently reported a recombinant GII. 4 P domain particle (Pd) vaccine adjuvanted with a flagellin, Vibrio vulnificus FlaB, effectively promoting both humoral and cell-mediated immune responses. In the previous study, we found that sublingual (SL) immunization induced higher fecal secretory IgA (SIgA) responses while intranasal (IN) route provided higher amplitude of humoral and cellular immune responses in the systemic compartment...
May 21, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29781418/waterborne-outbreak-of-gastroenteritis-on-the-kwazulu-natal-coast-south-africa-december-2016-january-2017
#11
P G Sekwadi, K G Ravhuhali, A Mosam, V Essel, G M Ntshoe, A M Shonhiwa, K McCarthy, J Mans, M B Taylor, N A Page, N Govender
An unexpected increase in gastroenteritis cases was reported by healthcare workers on the KwaZulu-Natal Coast, South Africa, January 2017 with >600 cases seen over a 3-week period. A case-control study was conducted to identify the source and risk factors associated with the outbreak so as to recommend control and prevention measures. Record review identified cases and controls and structured-telephonic interviews were conducted to obtain exposure history. Stool specimens were collected from 20 cases along with environmental samples and both screened for enteric pathogens...
May 21, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29780224/correlative-study-between-c-reactive-protein-clinical-severity-and-nerve-conduction-studies-in-guillain-barr%C3%A3-syndrome
#12
Yosria A Altaweel, Sawsan Abdelaziz, Hala A Fathy, Shimaa AbdelBadea
Background: Guillain-Barre' syndrome (GBS) is a serious autoimmune disorder in which the immune system attacks healthy nerve cells of the peripheral nervous system causing polyradiculoneuropathy which leads to weakness, numbness, and tingling, and can eventually cause paralysis. Autoimmune conditions like GBS can induce a high level of inflammation resulting in an increase in the C-reactive protein( CRP) production. The aim of this study is to assess the relationship between CRP level and the clinical severity as well as the electrophysiological findings of nerve conduction studies in patients with GBS...
2018: The Egyptian journal of neurology, psychiatry and neurosurgery
https://www.readbyqxmd.com/read/29779487/expression-purification-and-characterization-of-a-gii-4-norovirus-protease
#13
Benjamin D Kuiper, Bradley J Keusch, Joshua Holcomb, Kendall M Muzzarelli, Franck Amblard, Peng Liu, Shaoman Zhou, Iulia A Kovari, Zhe Yang, Raymond F Schinazi, Ladislau C Kovari
BACKGROUND: Noroviruses are the leading cause of acute gastroenteritis worldwide. Norovirus proteases, which are responsible for cleavage of the viral polyprotein, have become an attractive drug target to treat norovirus infections. Genogroup II (GII) noroviruses are responsible for a majority of outbreaks; however, limited data exist regarding GII norovirus proteases. METHOD: The Minerva virus protease (MVpro), a genogroup II genotype 4 (GII.4) norovirus protease was expressed in E...
May 20, 2018: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/29779228/prevalence-and-clinical-profile-of-rotavirus-a-infection-among-diarrheal-children-and-phylogenetic-analysis-with-vaccine-strains-in-chengdu-west-china-2009-2014
#14
Yu-Hang Chen, Fan Chen, Tao Zhou, Jia-Yi Chen, Tian-Li Zheng, Xin Xu, Xiao-Fang Pei
OBJECTIVES: Rotaviruses are the most common cause of severe diarrheal disease in young children. However, little is known about the epidemiological and clinical profile of rotavirus A (RVA) in diarrheal children or the efficacy of Lanzhou lamb rotavirus vaccine (LLR) in Chengdu, China. This study aimed to determine the prevalence and clinical profile of RVA in diarrheal children and provide gene analysis information for RVA vaccination programs. METHODS: 1121 fecal samples were collected from outpatient children with diarrhea between 2009 and 2014...
May 19, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29772466/research-on-the-contamination-levels-of-norovirus-in-food-facilities-using-groundwater-in-south-korea-2015-2016
#15
Jeong Su Lee, In Sun Joo, Si Yeon Ju, Min Hee Jeong, Yun-Hee Song, Hyo Sun Kwak
Norovirus (NoV) is a major pathogenic virus that is responsible for foodborne and waterborne gastroenteritis outbreaks. Groundwater is an important source of drinking water and is used in agriculture and food manufacturing processes. This study investigated norovirus contamination of groundwater treatment systems at 1360 sites in seven metropolitan areas and nine provinces in 2015-2016. Temperature, pH, residual chlorine, and turbidity content were assessed to analyze the water quality. In 2015, six sites were positive for the presence of NoV (0...
May 11, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29772399/characterization-of-a-g10p-14-rotavirus-strain-from-a-diarrheic-child-in-thailand-evidence-for-bovine-to-human-zoonotic-transmission
#16
Ratana Tacharoenmuang, Satoshi Komoto, Ratigorn Guntapong, Tomihiko Ide, Phakapun Singchai, Sompong Upachai, Saori Fukuda, Yumika Yoshida, Takayuki Murata, Tetsushi Yoshikawa, Kriangsak Ruchusatsawat, Kazushi Motomura, Naokazu Takeda, Somchai Sangkitporn, Koki Taniguchi
An unusual rotavirus strain, DB2015-066 with the G10P[14] genotype (RVA/Human-wt/THA/dB2015-066/2015/G10P[14]), was detected in a stool sample from a child hospitalized with acute gastroenteritis in Thailand. Here, we sequenced and characterized the full-genome of the strain DB2015-066. On whole genomic analysis, strain DB2015-066 was shown to have a unique genotype constellation: G10-P[14]-I2-R2-C2-M2-A3-N2-T6-E2-H3. The backbone genes of this strain (I2-R2-C2-M2-A3-N2-T6-E2-H3) are commonly found in rotavirus strains from artiodactyls such as cattle...
May 14, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29770061/canadian-public-health-laboratory-network-position-statement-non-culture-based-diagnostics-for-gastroenteritis-and-implications-for-public-health-investigations
#17
B Berenger, L Chui, A R Reimer, V Allen, D Alexander, M-C Domingo, D Haldane, L Hoang, P Levett, A MacKeen, D Marcino, C Sheitoyan-Pesant, G Zahariadis
As clinical laboratories transition to using culture-independent detection test (CIDT) panels for cases of acute gastroenteritis, culture of clinical specimens is becoming less common. The reduction in bacterial cultures available for public health activities is expected to hinder surveillance and outbreak response by public health laboratories at the local, provincial, national and international levels. These recommendations are intended to serve as guidelines for the implementation of CIDT panels in frontline laboratories in Canada...
December 7, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29769338/the-perk-arm-of-the-unfolded-protein-response-negatively-regulates-transmissible-gastroenteritis-virus-replication-by-suppressing-protein-translation-and-promoting-type-i-ifn-production
#18
Mei Xue, Fang Fu, Yanlong Ma, Xin Zhang, Liang Li, Li Feng, Pinghuang Liu
Coronavirus replication is closely associated with the endoplasmic reticulum (ER), the primary cellular organelle for protein synthesis, folding, and modification. ER stress is a common consequence in coronavirus-infected cells. However, how the virus-induced ER stress influences coronavirus replication and pathogenesis remains controversial. Here, we demonstrated that infection with the alphacoronavirus transmissible gastroenteritis virus (TGEV) induced ER stress and triggered the unfolded protein response (UPR) in vitro and in vivo , and ER stress negatively regulated TGEV replication in vitro Although TGEV infection activated all three UPR pathways (ATF6, IRE1, and PERK), the virus-triggered UPR suppressed TGEV replication in both ST and IPEC-J2 cells primarily through activation of the PERK-eIF2α axis, as shown by functional studies with overexpression, siRNA, or specific chemical inhibitors...
May 16, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29768564/meningitis-caused-by-salmonella-enterica-serotype-panama-in-brazil-first-case-reported
#19
Maria Regina Pires Carneiro, Maria Iracema de Aguiar Patrício, Sona Jain, Dalia Dos Prazeres Rodrigues, Sergio Eduardo Longo Fracalanzza
Salmonella infections usually occur as gastroenteritis that is generally self-limited. However, some serotypes of Salmonella can cause severe extra-intestinal infections, such as bacteremia and meningitis. Here, we report the first Salmonella Panama case of meningitis in 4-month-old male newborn in Brazil. The invasive strain isolated was susceptible to all antimicrobial agents tested. The genes agfA, fimA, invA, sfbA, phoP, and slyA were detected using polymerase chain reactions. These findings are relevant and physicians should be alert to the possibility of meningitis in newborns due to S...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29768293/seasonality-of-common-pediatric-infectious-diseases
#20
Susan C Lipsett, Michael C Monuteaux, Andrew M Fine
BACKGROUND/OBJECTIVE: Traditional sources cite seasonal patterns for common infectious diseases, often based on microbiologic data, but little is known about cyclical trends in clinically diagnosed infectious conditions in the emergency department (ED). We leveraged the publicly available Nationwide Emergency Department Sample database to measure the seasonality of the most common pediatric infectious diseases diagnosed in US EDs. METHODS: We searched the Nationwide Emergency Department Sample database to identify infectious diagnoses comprising at least 1% of all diagnosis codes ascribed to patients 21 years and younger in US EDs from 2009 to 2013...
May 15, 2018: Pediatric Emergency Care
keyword
keyword
90886
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"