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Epithelioid angiosarcoma

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https://www.readbyqxmd.com/read/27818284/cardiac-angiosarcoma-histopathologic-immunohistochemical-and-cytogenetic-analysis-of-10-cases
#1
Charles Leduc, Sarah M Jenkins, William R Sukov, Jeannette G Rustin, Joseph J Maleszewski
Angiosarcoma (AS) is the most common cardiac sarcoma with differentiation, and is poorly characterized from a molecular genetic standpoint. Prognosis remains poor, owing to several factors including aggressive tumor biology, poor response to adjuvant therapy, and lack of targeted therapy. The clinical, pathologic and molecular cytogenetic features were studied in ten cardiac AS surgically resected at Mayo Clinic (1994-2015) using a whole genome single nucleotide polymorphism based platform (OncoScan). Mean patient age was 47...
November 3, 2016: Human Pathology
https://www.readbyqxmd.com/read/27790305/post-radiation-epithelioid-angiosarcoma-of-the-urinary-bladder-and-prostate
#2
Gang Wang, Peter C Black, Brian F Skinnider, Malcolm M Hayes, Edward C Jones
Angiosarcoma of the lower urinary tract is exceedingly rare. A minority of cases are associated with local radiotherapy. Epithelioid angiosarcoma is a variant of angiosarcoma composed of large rounded epithelioid endothelial cells that are positive for cytokeratin on immunostaining. There are only two cases of post-radiation epithelioid angiosarcoma reported in the urinary bladder, and none in the prostate gland. We report a case of epithelioid angiosarcoma involving the urinary bladder and prostate in a patient with a history of radiotherapy for prostatic adenocarcinoma...
May 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27785659/implications-of-lymph-node-evaluation-in-the-management-of-resectable-soft-tissue-sarcoma
#3
Brett L Ecker, Madalyn G Peters, Matthew T McMillan, Andrew J Sinnamon, Paul J Zhang, Rachel R Kelz, Robert E Roses, Jeffrey A Drebin, Douglas L Fraker, Giorgos C Karakousis
BACKGROUND: The rate of lymph node (LN) metastasis is rare in soft tissue sarcoma, but there are histologic subtypes that metastasize via the lymphatics. The prognostic value of LN evaluation in these high-risk histologies is unknown. METHODS: Resected soft-tissue sarcoma patients with clear cell sarcoma, epithelioid sarcoma, rhabdomyosarcoma, or angiosarcoma (n = 2993) were identified in the National Cancer Data Base (2004-2013). Cox regression evaluated the association of omission of LN assessment (NX) and overall survival (OS)...
October 26, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27772857/disseminated-epithelioid-angiosarcoma-presenting-as-multiple-intestinal-polyps-with-active-bleeding
#4
Roumina Hasan, Vidya Monappa
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27686553/myc-amplification-in-angiosarcomas-arising-in-the-setting-of-chronic-lymphedema-of-morbid-obesity
#5
David Harker, Michael Jennings, Patrick McDonough, Melissa Mauskar, Stephanie Savory, Gregory A Hosler, Travis Vandergriff
BACKGROUND: Angiosarcoma is a malignancy of vascular endothelial cells which may arise secondarily as a complication of lymphedema, including chronic lymphedema of morbid obesity. Amplifications in MYC are frequently present in secondary angiosarcoma (arising in irradiated sites and chronic lymphedema) and less frequently in primary cutaneous angiosarcoma. OBJECTIVE: To describe the presence of MYC amplifications in two cases of cutaneous angiosarcoma secondary to chronic lymphedema of morbid obesity...
September 30, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27684838/uncommon-liver-tumors-case-report-and-literature-review
#6
Chia-Hung Wu, Nai-Chi Chiu, Yi-Chen Yeh, Yu Kuo, Sz-Shian Yu, Ching-Yao Weng, Chien-An Liu, Yi-Hong Chou, Yi-You Chiou
BACKGROUND: Beside hepatocellular carcinoma, metastasis, and cholangiocarcinoma, the imaging findings of other relatively uncommon hepatic lesions are less discussed in the literature. Imaging diagnosis of these lesions is a daily challenge. In this article, we review the imaging characteristics of these neoplasms. METHODS: From January 2003 to December 2014, 4746 patients underwent liver biopsy or hepatic surgical resection in our hospital. We reviewed the pathological database retrospectively...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27617941/epithelioid-angiosarcoma-of-the-skin-a-malignant-tumor-mimicking-many-different-neoplasms
#7
Jorge Santos-Juanes1, Blanca Vivanco-Allende, Cristina Galache Galache
Epithelioid angiosarcomas are rare malignant mesenchymal tumors. The main problem of these tumors is the complicate clinical and histological diagnosis. We report a case with an immunohistochemical panel. We propose the use of CD31 in the immunohistochemical panel of an undifferenciated tumor with epithelioid features, because it appears to be the only endothelial marker these tumors constantly express.
2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27607156/primary-left-tibial-epithelioid-hemangioendotheliomas-with-multiple-metastases-revealed-by-fdg-pet-ct-imaging
#8
Haimin Zhao, Jiankui Han, Lei Qin, Changming Zhang
Bone epithelioid angiosarcoma is an extremely rare osseous malignancy with an aggressive and destructive biological behavior. We present FDG PET/CT findings of a 59-year-old woman with left lower limb pain for 1 month. The images revealed abnormal activity in both left fibula and left tibia. In addition, abnormal activity in the sacrum and enlarged retroperitoneal lymph nodes was also noted. Pathological examination demonstrated bone epithelioid angiosarcoma.
November 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27515856/diagnostic-utility-of-fosb-immunohistochemistry-in-pseudomyogenic-hemangioendothelioma-and-its-histological-mimics
#9
Shintaro Sugita, Hiroshi Hirano, Noriaki Kikuchi, Terufumi Kubo, Hiroko Asanuma, Tomoyuki Aoyama, Makoto Emori, Tadashi Hasegawa
BACKGROUND: Pseudomyogenic hemangioendothelioma (PHE) is an unusual vascular tumor of intermediate malignancy that rarely metastasizes and tends to arise in the lower limbs of young adults and children. Histologically, PHE shows fascicular proliferation of eosinophilic spindle cells and/or epithelioid cells showing "pseudomyogenic" morphology. Immunohistochemically, PHE is usually positive for vimentin, cytokeratin, CD31 and ERG. METHOD: We examined FOSB immunohistochemistry (IHC) in 27 cases consisting of 4 PHE and its histologic mimics including 6 epithelioid hemangioendotheliomas (EHE), 8 angiosarcomas (AS), 4 Kaposi sarcomas (KS) and 5 epithelioid sarcomas (ES)...
August 11, 2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27510689/pulmonary-hemangioendothelioma-with-osteoclast-like-giant-cells-a-rare-observation
#10
Shraddha A Adamane, Kedar K Deodhar, Amit M Gupta, George Karimundackal, Sangeeta B Desai
Pulmonary epithelioid hemangioendothelioma (PEH) is a rare vascular neoplasm, predominantly encountered in women, more often in the age group of 40 years and below. It is a tumor of borderline malignant potential with a clinical course intermediate between hemangioma and angiosarcoma. The tumor has variable prognosis, and treatment options include surgical excision in operable cases and chemotherapy in disseminated ones. The present report describes complete clinical, radiological, and histopathological features of PEH with osteoclast-like giant cells and metaplastic ossification in a 20-year-old boy who presented with dyspnea and episodes of hemoptysis with review of literature...
July 2016: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/27502347/a-rare-case-of-primary-epithelioid-angiosarcoma-of-the-ureter
#11
P Padaki, R Hutton, T Amer, R Hasan, D Pugh, B Little
Angiosarcoma is an extremely rare vascular malignancy with a 1-year survival rate of 50%, regardless of tumour origin. Distant metastases are common and occur in the lungs, bone, lymph nodes and soft tissues. The majority of patients with angiosarcoma present with localised disease, although 25-45% have distant metastases at presentation. There are few reported cases of angiosarcomas of the bladder and we report the second case in the literature of primary angiosarcoma of the ureter. We suggest that, in atypical manifestations of suspected urothelial malignancy, the multidisciplinary team considers the possibility of rarer, aggressive tumours early...
August 9, 2016: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/27498194/malignant-myoepithelioma-of-the-breast-clinically-and-histologically-masquerading-as-angiosarcoma-cytological-findings-and-review-of-the-literature
#12
Helen Trichia, Olena Ignatova, Joanna Lekka, Maria Papazian, Panagiotis Manikis
BACKGROUND: Malignant myoepithelioma of the breast is an exceptionally rare, aggressive tumor with a diverse morphology, the cytological features of which have only occasionally been described. CASE REPORT: Our case comprises a 74-year-old woman who was admitted to our hospital with an erythematous, inflammatory-like mass of her left breast with nipple ulceration, and clinically fixed to the chest wall. The woman underwent fine-needle aspiration and biopsy. The aspirates consisted mainly of loose aggregates of large, highly pleomorphic, polygonal epithelioid cells as well as aggregates of spindle cells with prominent, easily detectable mitoses and single, multinucleated pleomorphic giant cells...
2016: Acta Cytologica
https://www.readbyqxmd.com/read/27391643/aortic-endograft-and-epithelioid-sarcoma-a-random-association-or-causality
#13
Nitin Tiwari, Sheila Krishna, Alex G Ortega-Loayza
BACKGROUND: Angiosarcoma is an uncommon, malignant neoplasm often found in skin and soft tissue. Epithelioid angiosarcoma (EA) is a rarer, more aggressive form of angiosarcoma most common in men in their seventh decade. Dacron<sup>®</sup>, a polymer comprised of polyethylene terephthalate used in endografts for abdominal aortic aneurysm repairs, has been a suspected carcinogen associated with EA. Currently, three case reports exist in the literature purporting Dacron<sup>®</sup>-associated epithelioid angiosarcoma...
July 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27318413/contributions-of-dr-juan-rosai-to-the-pathology-of-cutaneous-vascular-proliferations-a-review-of-selected-lesions
#14
Mark R Wick
Vascular proliferations in the skin have been thoroughly studied over the past 35 years, and a great deal of knowledge has been accrued regarding their pathobiological features. Dr. Juan Rosai has been a consistent contributor to the literature on this topic throughout most of his career, and this article reviews selected cutaneous endothelial lesions that he helped to characterize. They include histiocytoid-epithelioid hemangioma, targetoid-hobnail hemangioma, acquired tufted hemangioma, glomeruloid hemangioma, spindle cell hemangioma, retiform hemangioendothelioma, and angiosarcoma...
September 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27256041/-clinicopathologic-study-of-primary-angiosarcoma-of-thyroid
#15
H Li, H X Li, Y Zhu, Z H Zhang, Q H Fan
OBJECTIVE: To investigate the clinicopathologic characteristics of primary angiosarcoma in thyroid. METHODS: Three cases of primary angiosarcoma in thyoid were analyzed by gross examination, light microscopy and immunohistochemical staining, as well as related literatures were reviewed. RESULTS: The patients included 2 males and 1 female. The age of patients ranged from 52 to 78 years. The tumors showed an infiltrating histological pattern...
June 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/27238982/aortic-epithelioid-angiosarcoma-after-endovascular-aneurysm-repair
#16
Domenico Milite, Fabio Pilon, Alessandra Ferrari, Daniela Danieli, Alessandro Desole
We report a case of epithelioid angiosarcoma of the abdominal aortic wall after endovascular treatment for abdominal aortic aneurysm (EVAR). A 60-year-old male, treated 7 years before with EVAR, presented with abdominal back pain, general fatigue, and fever. It was assumed to be a graft infection with periaortic tissue compatible with an inflammatory reaction. The endograft was therefore completely removed and a Dacron silver aorto-bisiliac graft was implanted. After a few days the patient worsened, the angio-computed tomography scan showed a progressive increase of the periaortic mass and numerous small nodules in the abdomen were also detected...
August 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27229516/epithelioid-angiosarcoma-of-the-thyroid-gland-without-distant-metastases-at-diagnosis-report-of-six-cases-with-a-long-follow-up
#17
Paola Collini, Marta Barisella, Salvatore L Renne, Natalia Pizzi, Davide Mattavelli, Silvia Stacchiotti, Franco Mattavelli
We present six cases of epithelioid angiosarcomas (EAS) of the thyroid gland without distant metastases at diagnosis and with a long follow-up. We retrieved the six consecutive cases of thyroid EAS between 2005 and 2011. Gender was equally represented; median age was 60 years (range 53-68). One case was post-irradiation and another post-exposure to vinyl chloride. Median diameter was 6 cm (range 5-13). Regional nodal metastases were present at onset in two cases. All the cases expressed CD31 in a membranous pattern...
August 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27220541/cutaneous-angiosarcoma-mimicking-xanthoma-a-challenging-histopathologic-diagnosis-with-important-consequences
#18
Mar Llamas-Velasco, Heinz Kutzner, Luis Requena
Cutaneous angiosarcoma may show protean histopathologic features. Rare or uncommon variants include epithelioid, clear cell, granular cell, verrucous, pseudolymphomatous and signet-ring cell types. Perhaps the rarest type consists of cutaneous angiosarcoma with xanthomization of neoplastic cells. We report an extraordinary case with almost all neoplastic cells exhibiting a xanthomatous appearance that was studied both histopathologically and immunohistochemically. We discuss the histopathologic differential diagnosis of foamy cell angiosarcoma with other neoplasms that may show similar histopathology...
September 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27162541/prognostic-significance-of-forkhead-box-m1-foxm1-expression-and-antitumor-effect-of-foxm1-inhibition-in-angiosarcoma
#19
Takamichi Ito, Kenichi Kohashi, Yuichi Yamada, Takeshi Iwasaki, Akira Maekawa, Masaaki Kuda, Daichi Hoshina, Riichiro Abe, Masutaka Furue, Yoshinao Oda
BACKGROUND: The prognosis of angiosarcoma is poor and a novel treatment option for the disease is desired. The aim of this study was to investigate the prognostic significance of Forkhead box M1 (FOXM1), a transcription factor that regulates cell-cycle progression and various crucial processes in tumor progression, and its potential as a new therapeutic target. METHODS: We investigated 125 angiosarcoma clinical samples (94 primary lesions and 31 metastatic lesions in 94 patients) and a human angiosarcoma cell line (HAMON) using immunohistochemical staining and molecular biological approaches...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27123135/imaging-features-of-soft-tissue-epithelioid-angiosarcoma-in-the-lower-extremity-a-case-report
#20
Lulu Lv, Peng Xu, Yibing Shi, Jingming Hao, Chunai Hu, Baozhong Zhao
Epithelioid angiosarcomas are extremely rare malignant tumors formed from endothelial cells. The majority of studies reporting these tumors have been concerned with the clinical and pathological aspects, with limited reporting of radiological diagnosis. The aim of the present study was to provide a reference to improve understanding of diagnosis, treatment choice and prognosis assessment of epithelioid angiosarcoma. The current study reports the case of a 44-year-old woman with epithelioid angiosarcoma located in the deep soft tissue of the lower extremities...
May 2016: Oncology Letters
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