keyword
MENU ▼
Read by QxMD icon Read
search

vancomycin resistance

keyword
https://www.readbyqxmd.com/read/28532398/clinical-outcomes-of-linezolid-and-vancomycin-in-patients-with-nosocomial-pneumonia-caused-by-methicillin-resistant-staphylococcus-aureus-stratified-by-baseline-renal-function-a-retrospective-cohort-analysis
#1
Ping Liu, Blair Capitano, Amy Stein, Ali A El-Solh
BACKGROUND: The primary objective of this study is to assess whether baseline renal function impacts treatment outcomes of linezolid and vancomycin (with a dose-optimized regimen) for methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. METHODS: We conducted a retrospective cohort analysis of data generated from a prospective, randomized, controlled clinical trial (NCT 00084266). The analysis included 405 patients with culture-proven MRSA pneumonia. Baseline renal function was stratified based on creatinine clearance...
May 22, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28528048/real-time-autofluorescence-imaging-to-diagnose-lvad-driveline-infections
#2
Jack B Keenan, Taufiek Konrad Rajab, David G Armstrong, Zain Khalpey
A 64-year-old man experienced a driveline infection that was treated with serial debridements and antibiotics. When the wound clinically appeared ready for closure, a handheld fluorescence imaging device still revealed a margin of red fluorescence around the wound edges consistent with a subclinical infection. Therefore, a wider margin was made and additional specimens for wound culture were taken, which demonstrated a vancomycin-resistant enterococcal infection. The autofluorescence signals of common bacteria can be detected with a fluorescence camera in subclinical wound infections without clinical signs...
June 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28527358/improving-the-pharmacokinetics-and-tissue-distribution-of-pyrinezolid-by-self-assembled-polymeric-micelles
#3
Haiyue Long, Xiaoling Li, Zitai Sang, Lan Mei, Tao Yang, Zicheng Li, Liangxue Zhou, Yu Zheng, Gu He, Gang Guo, Zhenling Wang, Yong Deng, Youfu Luo
Antibiotic-resistance by bacteria is a growing global concern within the healthcare field, and it has provided an impetus for continued antimicrobial development. Pyrinezolid (PZ), a novel oxazolidinone compound, can effectively inhibit most gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). Though PZ is a promising antimicrobial candidate, the druggability of PZ is limited by its poor water solubility. Therefore, the amphipathic mPEG-PLLA copolymer was used to prepare the pyrinezolid micelles (PZ-M)...
May 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28527243/-synthesis-of-antibiotic-loaded-polylactic-acid-nanoparticles-and-their-antibacterial-activity-against-escherichia-coli-o157-h7-and-methicillin-resistant-staphylococcus-aureus
#4
Mónica Tatiana Herrera, Jhon Jhamilton Artunduaga, Claudia Cristina Ortiz, Rodrigo Gonzalo Torres
INTRODUCTION: Polymeric nanoparticles are promising nanotechnology tools to fight pathogenic bacteria resistant to conventional antibiotics. OBJECTIVE: To synthesize polylactic acid nanoparticles loaded with ofloxacin and vancomycin, and to determine their antibacterial activity against Escherichia coli O157:H7 and methicillin-resistant Staphylococcus aureus (MRSA). MATERIALS AND METHODS: We synthesized ofloxacin or vancomycin loaded polylactic acid nanoparticles by the emulsification-solvent evaporation method, and characterized them by dynamic light scattering, laser Doppler electrophoresis and scanning electron microscopy...
January 24, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527125/diversity-and-probiotic-potential-of-lactic-acid-bacteria-isolated-from-horreh-a-traditional-iranian-fermented-food
#5
Alireza Vasiee, Behrooz Alizadeh Behbahani, Farideh Tabatabaei Yazdi, Seyed Ali Mortazavi, Hamid Noorbakhsh
The aim of this study was to evaluate the probiotic potential of lactic acid bacteria (LAB) strains isolated from Horreh. Some probiotic properties, e.g., resistance to acid, bile tolerance, antibacterial activity, and antibiotic susceptibility, were investigated. A total of 140 Gram-positive and catalase-negative isolates from Horreh were subjected to identification and grouping by cultural methods and the 16S rRNA sequencing. The new isolates were identified to be Lactobacillus (fermentum, plantarum, and brevis) Weissella cibaria, Enterococcus (faecium and faecalis), Leuconostoc (citreum and mesenteroides subsp...
May 19, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28525287/occurrence-of-enterococcus-faecalis-and-enterococcus-faecium-in-various-clinical-infections-detection-of-their-drug-resistance-and-virulence-determinants
#6
Ali Jahansepas, Mohammad Aghazadeh, Mohammad Ahangarzadeh Rezaee, Alka Hasani, Yaeghob Sharifi, Toofan Aghazadeh, Jalal Mardaneh
The aim of this study was to characterize virulence determinants and antibiotic resistance profiles in enterococci obtained from various clinical sources in the northwest of Iran. A total of 160 enterococcal clinical isolates from various wards of University Teaching Hospitals were collected and specified by biochemical test, from September 2014 to July 2015. Identification of enterococci was confirmed by multiplex PCR in the genus and species level. Antibiotic resistance properties and virulence determinants were examined by phenotypic and molecular methods...
May 19, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28522725/draft-genome-sequences-of-five-enterococcus-species-isolated-from-the-gut-of-patients-with-suspected-clostridium-difficile-infection
#7
Eduardo Castro-Nallar, Sandro L Valenzuela, Sebastián Baquedano, Carolina Sánchez, Fabiola Fernández, Annette N Trombert
We present draft genome sequences of five Enterococcus species from patients suspected of Clostridium difficile infection. Genome completeness was confirmed by presence of bacterial orthologs (97%). Gene searches using Hidden-Markov models revealed that the isolates harbor between seven and 11 genes involved in antibiotic resistance to tetracyclines, beta-lactams, and vancomycin.
May 18, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28515904/weekly-screening-supports-terminating-nosocomial-transmissions-of-vancomycin-resistant-enterococci-on-an-oncologic-ward-a-retrospective-analysis
#8
Stefanie Kampmeier, Dennis Knaack, Annelene Kossow, Stefanie Willems, Christoph Schliemann, Wolfgang E Berdel, Frank Kipp, Alexander Mellmann
BACKGROUND: To investigate the impact of weekly screening within the bundle of infection control measures to terminate vancomycin-resistant enterococci (VRE) transmissions on an oncologic ward. METHODS: A cluster of 12 VRE colonisation and five infections was detected on an oncologic ward between January and April 2015. Subsequently, the VRE point prevalence was detected and, as part of a the bundle of infection control strategies to terminate the VRE cluster, we isolated affected patients, performed hand hygiene training among staff on ward, increased observations by infection control specialists, intensified surface disinfection, used personal protective equipment and initiated an admission screening in May 2015...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28515641/molecular-typing-and-antimicrobial-susceptibility-of-staphylococcus-aureus-strains-isolated-from-raw-milk-cheese-minced-meat-and-chicken-meat-samples
#9
Hayriye Yeşim Can, Mehmet Elmalı, Alper Karagöz
The objectives of this study were: i) to detect the presence of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) in raw milk, cheese, beef minced meat, and chicken meat samples; ii) to evaluate the antimicrobial susceptibility of the isolates; and iii) to determine clonal relation among the isolates by using pulsed-field gel electrophoresis (PFGE) method. Therefore, a total of 160 food samples were randomly collected between August 2014 and May 2015 in Hatay province, located in the southern Turkey...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/28512606/antimicrobial-activity-of-nigerian-medicinal-plants
#10
REVIEW
Madubuike Umunna Anyanwu, Rosemary Chinazam Okoye
Antimicrobial resistance (AMR) is currently one of the major threats facing mankind. The emergence and rapid spread of multi- and pan-drug-resistant organisms (such as vancomycin-, methicillin-, extended-spectrum β-lactam-, carbapenem- and colistin-resistant organisms) has put the world in a dilemma. The health and economic burden associated with AMR on a global scale are dreadful. Available antimicrobials have been misused and are almost ineffective with some of these drugs associated with dangerous side effects in some individuals...
April 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28511809/characterisation-of-the-selective-binding-of-antibiotics-vancomycin-and-teicoplanin-by-the-vans-receptor-regulating-type-a-vancomycin-resistance-in-the-enterococci
#11
C S Hughes, E Longo, M K Phillips-Jones, R Hussain
A-type resistance towards "last-line" glycopeptide antibiotic vancomycin in the leading hospital acquired infectious agent, the enterococci, is the most common in the UK. Resistance is regulated by the VanRASA two-component system, comprising the histidine sensor kinase VanSA and the partner response regulator VanRA. The nature of the activating ligand for VanSA has not been identified, therefore this work sought to identify and characterise ligand(s) for VanSA. In vitro approaches were used to screen the structural and activity effects of a range of potential ligands with purified VanSA protein...
May 13, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28511382/rapid-identification-of-vancomycin-resistant-enterococcus-faecalis-clinical-isolates-using-a-sugar-fermentation-method
#12
Javad Raeisi, Mahnaz Saifi, Mohammad Reza Pourshafie, Mehri Habibi, Hamid Reza Mohajerani, Neda Akbari, Mohammad Reza Asadi Karam
INTRODUCTION: Vancomycin Resistant Enterococci (VRE) can be found all over the world. Thus, rapid detection of the isolates could be of high importance in the treatment or prevention of the associated disease. AIM: To measure the turanose fermentation in Enterococcus faecalis clinical isolates for rapid differentiation of VRE and Vancomycin-Susceptible E. faecalis (VSE) isolates. MATERIALS AND METHODS: Forty E. faecalis samples were isolated from 200 clinical samples in Tehran Medical Center, Iran, from October 2012 to December 2012...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28507244/inhibition-of-staphylococcus-aureus-cell-wall-biosynthesis-by-desleucyl-oritavancin-a-quantitative-peptidoglycan-composition-analysis-by-mass-spectrometry
#13
James D Chang, Erin E Foster, Aanchal N Thadani, Alejandro J Ramirez, Sung Joon Kim
Oritavancin is a lipoglycopeptide antibiotic that exhibits potent activities against vancomycin-resistant Gram-positive pathogens. Oritavancin differs from vancomycin by a hydrophobic side chain attached to the drug disaccharide, which forms a secondary-binding site to enable oritavancin binding to the cross-linked peptidoglycan in cell wall. The mode of action of secondary-binding site was investigated by measuring the changes in the peptidoglycan composition of Staphylococcus aureus grown in presence of desleucyl-oritavancin at sub-inhibitory concentration using liquid chromatography-mass spectrometry (LC-MS)...
May 15, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28506784/healthcare-personnelintestinal-colonization-with-multidrug-resistant-organisms
#14
Brooke K Decker, Anna F Lau, John P Dekker, Christine D Spalding, Ninet Sinaii, Sean Conlan, David K Henderson, Julia A Segre, Karen M Frank, Tara N Palmore
OBJECTIVES: This study aims to assess the association between patient contact and intestinal carriageof multidrug-resistant organisms (MDRO) by sampling healthcare personnel (HCP) and staff without patient contact. METHODS: For this observational study, we recruited400HCPwho worked in our 200-bed research hospitaland 400 subjectswithout patient contact between November 2013 and February 2015.Participants submitted two self-collected perirectal swabsand a questionnaire...
May 12, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28506250/antimicrobial-resistance-profile-of-staphylococcus-aureus-isolates-isolated-from-ear-discharges-of-patients-at-university-of-hawassa-comprehensive-specialized-hospital
#15
Serawit Deyno, Alemayehu Toma, Mesfin Worku, Muluken Bekele
BACKGROUND: Drug-resistant microorganism are a growing global danger. Strains of S. aureus have developed resistance to many commonly used antimicrobials due to indiscriminate use of antimicrobials, and treatment becoming a challenge. Studies assessing pattern and determinants of S. aureus resistance in ear infection in Ethiopia are very scarce. This study presents overview of pattern and determinants S. aureus resistance from samples of ear discharge in Ethiopia. METHOD: A prospective cross-sectional study was conducted on patients who visit ENT clinic of University of Hawassa comprehensive specialized hospital from February 1, 2016 to November 1, 2016...
May 15, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28504889/genetic-characterization-of-vana-enterococcus-faecium-isolates-from-wild-red-legged-partridges-in-portugal
#16
Vanessa Silva, Gilberto Igrejas, Isabel Carvalho, Fernando Peixoto, Lucas Cardoso, José Eduardo Pereira, Rosa Del Campo, Patricia Poeta
Vancomycin-resistant enterococci (VRE) have been detected in wild animals representing a public health concern. The red-legged partridge (Alectoris rufa) is a common game bird and its meat is consumed in several countries, including Portugal. Three hundred five fecal samples of red-legged partridge from the north of Portugal were screened for VRE. Samples were cultured on Slanetz-Bartley agar supplemented with vancomycin (4 mg/L) and six vanA-Enterococcus faecium were recovered. Isolates were tested for antibiotic resistance and virulence genes...
May 15, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28504620/identification-of-a-distinctive-phenotype-for-endocarditis-associated-clonal-complex-22-mrsa-isolates-with-reduced-vancomycin-susceptibility
#17
Helene Marbach, Eve Boakes, Steven Lynham, Malcolm Ward, Jonathan A Otter, Jonathan D Edgeworth
PURPOSE: We previously identified an association between CC22 meticillin-resistant Staphylococcus aureus (MRSA) bloodstream infection isolates with an elevated vancomycin MIC (V-MIC) in the susceptible range (1.5-2 mg l-1) and endocarditis. This study explores whether these isolates have a specific phenotype consistent with the clinical findings. METHODOLOGY: CC22 and CC30 MRSA isolates with high (1.5-2 mg l-1) and low (≤0.5 mg l-1) V-MICs were tested for fibrinogen and fibronectin binding, virulence in a Galleria mellonella caterpillar model, phenol soluble modulin production and accessory gene regulator (agr) expression...
May 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28504494/staphylococcus-aureus-nasal-carriage-and-its-antibiotic-resistance-profiles-in-children-in-high-altitude-areas-of-southwestern-china
#18
Zongrong Gong, Min Shu, Qing Xia, Shan Tan, Wei Zhou, Yu Zhu, Chaomin Wan
BACKGROUND/AIM: To describe the epidemiological profile of nasal carriage of Staphylococcus aureus (S. aureus) strains, its antibiotic resistance and mecA and Panton Valentine leukocidin (PVL) genes presence, in school children residing in high altitude areas of Southwestern China. METHODS: The cross sectional study screened nasal swabs taken from students for S.aureus. PCR was performed to identify mecA and PVL genes. RESULTS: Of the total 314 children 5...
June 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28500123/enterococcus-casseliflavus-septicaemia-associated-with-hepatobiliary-infection-in-a-75-year-old-man
#19
Rajanshu Verma, Allison L Baroco
Enterococcus casseliflavus is a rare non-faecium, non-faecalis, vancomycin-resistant enterococcus (VRE) that is responsible for up to 2% of all enterococcal infections. Septicaemia with this bacterium is usually seen in older patients with multiple comorbidities who have had several previous hospitalisations. Septicaemia with E. casseliflavus portends a poorer prognosis, and treatment usually involves administration of antienterococcal beta-lactams or anti-VRE medications such as linezolid or daptomycin. We present such a case of a 75-year-old man who developed E...
May 12, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28499907/occurrence-of-ampicillin-resistant-enterococcus-faecium-carrying-esp-gene-in-pet-animals-an-upcoming-threat-for-pet-lovers
#20
Khaled A Abdel-Moein, Mahmoud D El-Hariri, Momtaz O Wasfy, Ahmed Samir
OBJECTIVES: This study was carried out to investigate oral colonisation by Enterococcus faecalis and Enterococcus faecium in pet dogs and cats, with special reference to antibiotic resistance. METHODS: Oral swabs were collected from 63 pet dogs and 57 pet cats with no known history of hospitalisation. All samples were enriched in Kenner Fecal (KF) broth before being cultured on KF agar to isolate enterococci. E. faecalis and E. faecium were identified by biochemical and molecular techniques...
May 10, 2017: Journal of Global Antimicrobial Resistance
keyword
keyword
90881
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"