Tracy Y Wang, Lars G Svensson, Jun Wen, Andrew Vekstein, Marc Gerdisch, Vijay U Rao, Michael Moront, Doug Johnston, Renato D Lopes, Alma Chavez, Marc Ruel, Eugene H Blackstone, Richard C Becker, Vinod Thourani, John Puskas, Hussein R Al-Khalidi, David G Cable, John A Elefteriades, Alberto Pochettino, J Alan Wolfe, Allen Graeve, Ibrahim Sultan, Ashraf A Sabe, Hector I Michelena, John H Alexander
Apixaban, Warfarin, and On-X Mechanical Aortic ValvesAlthough vitamin K antagonists are the only oral anticoagulants approved with mechanical heart valves, this trial examined whether apixaban could be safely used in patients with an On-X mechanical aortic valve. A total of 863 such patients were assigned apixaban 5 mg twice daily or warfarin (target international normalized ratio 2.0 to 3.0). A total of 20 thrombotic events occurred in the apixaban group (4.2%/patient-year) and 6 events in the warfarin group (1...
July 2023: NEJM Evid