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https://www.readbyqxmd.com/read/28967560/benefit-of-adaptive-ct-based-treatment-planning-in-high-dose-rate-endorectal-brachytherapy-for-rectal-cancer
#1
Roy P J van den Ende, Eva C Rijkmans, Ellen M Kerkhof, Remi A Nout, Martijn Ketelaars, Mirjam S Laman, Corrie A M Marijnen, Uulke A van der Heide
PURPOSE: In this planning study, we investigated the dosimetric benefit of repeat CT-based treatment planning at each fraction vs. the use of a single CT-based treatment plan for all fractions for high-dose-rate endorectal brachytherapy (HDREBT) for rectal cancer. METHODS AND MATERIALS: We included 11 patients that received a CT scan with applicator in situ for all three fractions. The treatment plan of the first fraction was projected on the repeat CT scans to simulate the use of a single treatment plan...
September 26, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28943074/local-protocol-variations-for-image-guided-radiation-therapy-in-the-multicenter-dutch-hypofractionation-hypro-trial-impact-of-rectal-balloon-and-mri-delineation-on-anorectal-dose-and-gastrointestinal-toxicity-levels
#2
R C Wortel, W D Heemsbergen, R J Smeenk, M G Witte, A D Krol, F J Pos, L Incrocci
PURPOSE: The phase 3 HYpofractionated irradiation for PROstate cancer (HYPRO) trial randomized patients with intermediate- to high-risk localized prostate cancer to conventionally fractionated (78 Gy in 39 fractions) or hypofractionated (64.6 Gy in 19 fractions) radiation therapy. Differences in techniques and treatment protocols were present between participating centers. This study aimed to compare dose parameters and patient-reported gastrointestinal symptoms between these centers...
August 3, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28814898/reducing-rectal-injury-in-men-receiving-prostate-cancer-radiation-therapy-current-perspectives
#3
REVIEW
Nicholas A Serrano, Noah S Kalman, Mitchell S Anscher
Dose escalation is now the standard of care for the treatment of prostate cancer with radiation therapy. However, the rectum tends to be the dose-limiting structure when treating prostate cancer, given its close proximity. Early and late toxicities can occur when the rectum receives large doses of radiation therapy. New technologies allow for prevention of these toxicities. In this review, we examine the evidence that supports various dose constraints employed to prevent these rectal injuries from occurring...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28733200/hypothermic-cooling-measured-by-thermal-magnetic-resonance-imaging-feasibility-and-implications-for-virtual-imaging-in-the-urogenital-pelvis
#4
Douglas Skarecky, Hon Yu, Jennifer Linehan, Blanca Morales, Min-Ying Su, Peter Fwu, Thomas Ahlering
OBJECTIVE: To study the combination of thermal magnetic resonance imaging (MRI) and novel hypothermic cooling, via an endorectal cooling balloon (ECB), to assess the effective dispersion and temperature drop in pelvic tissue to potentially reduce inflammatory cascade in surgical applications. METHODS: Three male subjects, before undergoing robot-assisted radical prostatectomy, were cooled via an ECB, rendered MRI compatible for patient safety before ECB hypothermia...
July 18, 2017: Urology
https://www.readbyqxmd.com/read/28464996/the-effect-of-endorectal-balloon-on-anorectal-dose-during-postoperative-volumetric-arc-radiotherapy-of-prostate-cancer
#5
Tino Streller, Urs Rusch, Maria D Herraiz Lablanca, Ira Minneken, Yousef Najafi, Binaya Shrestha, Susanne Oertel, Oliver Riesterer
PURPOSE: To evaluate the impact of endorectal balloon (ERB) on anorectal dose during postoperative VMAT of prostate cancer. METHODS: In ten patients referred for salvage radiotherapy CTs were obtained without ERB and with air-filled ERB of 50ml and 100ml. CTs were repeated weekly (4-6 control CTs) and registered to the respective planning CT. For each planning CT, a VMAT plan was made with defined anorectal dose constraints and propagated on the respective control CTs...
April 29, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28407345/dosimetric-impacts-of-endorectal-balloon-in-cyberknife-stereotactic-body-radiation-therapy-sbrt-for-early-stage-prostate-cancer
#6
Hong F Xiang, Hsiao-Ming Lu, Jason A Efstathiou, Anthony L Zietman, Ricardo De Armas, Kathryn Harris, B Nicolas Bloch, Muhammad Mustafa Qureshi, Sean Keohan, Ariel E Hirsch
PURPOSE: In SBRT for prostate cancer, higher fractional dose to the rectum is a major toxicity concern due to using smaller PTV margin and hypofractionation. We investigate the dosimetric impact on rectum using endorectal balloon (ERB) in prostate SBRT. MATERIALS AND METHODS: Twenty prostate cancer patients were included in a retrospective study, ten with ERB and 10 without ERB. Optimized SBRT plans were generated on CyberKnife MultiPlan for 5 × 7.25 Gy to PTV under RTOG-0938 protocol for early-stage prostate cancer...
April 13, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28300377/a-comparison-between-hydrogel-spacer-and-endorectal-balloon-an-analysis-of-intrafraction-prostate-motion-during-proton-therapy
#7
COMPARATIVE STUDY
Samantha G Hedrick, Marcio Fagundes, Ben Robison, Marc Blakey, Jackson Renegar, Mark Artz, Niek Schreuder
The purpose of this study was to evaluate intrafraction prostate motion in patients treated with proton therapy and an endorectal balloon or a hydrogel spacer using orthogonal x-rays acquired before and after each treatment field. This study evaluated 10 patients (662 fields throughout treatment) treated daily with an endorectal balloon (ERB) and 16 patients (840 fields throughout treatment) treated with a hydrogel spacer (GEL) without an ERB. Patient shifts were recorded before and after each treatment field, correlated with a treatment time, using x-ray imaging and implanted fiducial alignment...
March 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297294/real-time-in-vivo-dosimetry-for-sbrt-prostate-treatment-using-plastic-scintillating-dosimetry-embedded-in-a-rectal-balloon-a-case-study
#8
Justin L Cantley, Chee-Wai Cheng, Fredrick B Jesseph, Tarun K Podder, Valdir C Colussi, Bryan J Traughber, Lee E Ponsky, Rodney J Ellis
A novel FDA approved in vivo dosimetry device system using plastic scintillating detectors placed in an endorectal balloon to provide real-time in vivo dosimetry for prostatic rectal interface was tested for use with stereotactic body radiotherapy (SBRT). The system was used for the first time ever to measure dose during linear accelerator based SBRT. A single patient was treated with a total dose of 36.25 Gy given in 5 fractions. Delivered dose was measured for each treatment with the detectors placed against the anterior rectal wall near the prostate rectal interface...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28046755/su-f-j-122-rectal-sparing-reproducibility-in-prostate-cancer-patients-treated-with-hydrogel-spacer-and-proton-therapy
#9
S Hedrick, S Case, B Robison, M Blakey, M Artz, J Renegar, A Schreuder, M Fagundes
PURPOSE: Rectal hydrogel spacer has been shown to improve rectal sparing in prostate radiotherapy. The purpose of this study was to determine the reproducibility of rectal sparing throughout treatment in patients undergoing proton therapy. METHODS: At our facility, prostate cancer patients are treated with pencil beam scanning proton therapy, utilizing an endorectal balloon (ERB) or rectal spacer hydrogel (Gel) "SpaceOAR" implant. All patients were treated with a full bladder and empty rectum (low residue diet and stool softeners)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046335/su-g-jep4-09-impact-of-interfractional-motion-on-hypofractionated-pencil-beam-scanning-proton-therapy-for-prostate-cancer
#10
M Moteabbed, A Trofimov, G Sharp, Y Wang, A Zietman, J Efstathiou, H Lu
PURPOSE: To investigate the impact of anatomy/setup variations on standard vs. hypofractionated anterolateral pencil beam scanning (PBS) proton therapy for prostate cancer. METHODS: Six prostate cancer patients treated with double-scattering proton therapy, who underwent weekly verification CT scans were selected. Implanted fiducials were used for localization, and endorectal balloons for immobilization. New PBS plans using combination of lateral and anterior-oblique (AO) (±35 deg) beams were created...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27929503/real-time-in-vivo-dosimetry-for-sbrt-prostate-treatment-using-plastic-scintillating-dosimetry-embedded-in-a-rectal-balloon-a-case-study
#11
Justin L Cantley, Chee-Wai Cheng, Fredrick B Jesseph, Tarun K Podder, Valdir C Colussi, Bryan J Traughber, Lee E Ponsky, Rodney J Ellis
A novel FDA approved in vivo dosimetry device system using plastic scintillating detectors placed in an endorectal balloon to provide real-time in vivo dosimetry for prostatic rectal interface was tested for use with stereotactic body radiotherapy (SBRT). The system was used for the first time ever to measure dose during linear accelerator based SBRT. A single patient was treated with a total dose of 36.25 Gy given in 5 fractions. Delivered dose was measured for each treatment with the detectors placed against the anterior rectal wall near the prostate rectal interface...
November 8, 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27674238/meeting-dose-objectives-in-stereotactic-body-radiation-therapy-for-prostate-cancer-water-versus-air-filled-endorectal-balloon
#12
L Tsvang, A Dubouloz, D Alezra, Z Symon, R Miralbell
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27602248/efficacy-and-safety-of-botulinum-toxin-in-treatment-of-anismus-a-systematic-review
#13
Sameh Hany Emile, Hossam Ayman Elfeki, Hosam Ghazy Elbanna, Mohamed Youssef, Waleed Thabet, Tito M Abd El-Hamed, Basem Said, Ahmed Lotfy
AIM: To evaluate the efficacy and safety of botulinum toxin type A (BTX-A) in the management of patients with anismus. METHODS: An organized search of published literature was conducted using electronic databases including: PubMed/MEDLINE, and Cochrane Central Register of Controlled Trials, also an internet-based search using "Google Scholar" service was conducted. Both comparative and observational studies were included. We excluded irrelevant articles, editorials, case reports, reviews, and meta-analyses...
August 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27307750/analysis-of-prostate-bed-motion-using-an-endorectal-balloon-and-cone-beam-computed-tomography-during-postprostatectomy-radiotherapy
#14
Ji Hyeon Joo, Yeon Joo Kim, Young Seok Kim, Young Pil Cho, Ho Yeon Lee, Chang Young Jeong, Jungwon Kwak, Byung Chul Cho
BACKGROUND: The authors conducted this prospective study to analyze the amount of interfractional prostate bed motion (PBM) and quantify its components with the use of an endorectal balloon (ERB). METHODS: A total of 1,348 cone beam computed tomography images from 46 patients who underwent postprostatectomy radiotherapy were analyzed. For the pilot image, electronic portal imaging, guided by skin marks was performed to ensure proper positioning and inflation of the ERB...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27247058/quantification-of-vaginal-motion-associated-with-daily-endorectal-balloon-placement-during-whole-pelvis-radiotherapy-for-gynecologic-cancers
#15
Nicolette Taku, Joseph Dise, Owen Kenton, Lingshu Yin, Boon-Keng Kevin Teo, Lilie L Lin
BACKGROUND AND PURPOSE: To quantify intra-treatment vaginal motion in women treated with daily endorectal balloon (ERB) placement and external beam radiotherapy for gynecologic cancers. MATERIALS AND METHODS: Eighteen post-hysterectomy women with gynecologic cancers underwent computed tomography (CT) simulation scans and daily treatment with ERB. Fiducial markers were placed at the vaginal apex prior to simulation and patients were counseled on a pre-treatment bladder filling protocol...
September 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27222297/two-dimensional-in-vivo-rectal-dosimetry-using-an-endorectal-balloon-with-unfoldable-radiochromic-film-during-prostate-cancer-radiotherapy
#16
Eun Hee Jeang, Soonki Min, Kwan Ho Cho, Ui-Jung Hwang, Sang Hyoun Choi, Jungwon Kwak, Jong Hwi Jeong, Haksoo Kim, Se Byeong Lee, Dongho Shin, Jeonghoon Park, Joo-Young Kim, Dae Yong Kim, Young Kyung Lim
BACKGROUND AND PURPOSE: The present study aims to investigate the feasibility of two-dimensional (2D) in vivo rectal dosimetry using an endorectal balloon for the radiotherapy of prostate cancer. MATERIALS AND METHODS: The endorectal balloon was equipped with an unfoldable radiochromic film. The film was unrolled as the balloon was inflated, and rolled as it was deflated. Its mechanical and imaging properties were tested, and the dosimetric effectiveness was evaluated in clinical photon and proton beams...
August 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27145164/prospective-mri-based-imaging-study-to-assess-feasibility-of-proton-therapy-for-post-prostatectomy-radiation
#17
Samuel Swisher-McClure, Lingshu Yin, Mark Rosen, Sonny Batra, Abigail T Berman, Stefan Both, Neha Vapiwala
PURPOSE/OBJECTIVES: To optimize delivery of post-prostatectomy radiation (PPRT) with protons by examining dosimetric effects of variations in physician contouring, organ motion, and patient alignment during a course of PPRT. MATERIAL AND METHODS: We enrolled 10 patients receiving PPRT in a prospective imaging study. All patients underwent combined computed tomography (CT)/magnetic resonance imaging (MRI) simulation with endorectal balloon (ERB) and received intensity modulated radiation therapy (IMRT) per institutional standards...
July 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27002470/clinical-commissioning-of-an-in-vivo-range-verification-system-for-prostate-cancer-treatment-with-anterior-and-anterior-oblique-proton-beams
#18
M Hoesl, S Deepak, M Moteabbed, G Jassens, J Orban, Y K Park, K Parodi, E H Bentefour, H M Lu
The purpose of this work is the clinical commissioning of a recently developed in vivo range verification system (IRVS) for treatment of prostate cancer by anterior and anterior oblique proton beams. The IRVS is designed to perform a complete workflow for pre-treatment range verification and adjustment. It contains specifically designed dosimetry and electronic hardware and a specific software for workflow control with database connection to the treatment and imaging systems. An essential part of the IRVS system is an array of Si-diode detectors, designed to be mounted to the endorectal water balloon routinely used for prostate immobilization...
April 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/26907917/a-prospective-comparison-of-the-effects-of-interfractional-variations-on-proton-therapy-and-intensity-modulated-radiation-therapy-for-prostate-cancer
#19
RANDOMIZED CONTROLLED TRIAL
Maryam Moteabbed, Alexei Trofimov, Gregory C Sharp, Yi Wang, Anthony L Zietman, Jason A Efstathiou, Hsiao-Ming Lu
PURPOSE: To quantify and compare the impact of interfractional setup and anatomic variations on proton therapy (PT) and intensity modulated radiation therapy (IMRT) for prostate cancer. METHODS AND MATERIALS: Twenty patients with low-risk or intermediate-risk prostate cancer randomized to receive passive-scattering PT (n=10) and IMRT (n=10) were selected. For both modalities, clinical treatment plans included 50.4 Gy(RBE) to prostate and proximal seminal vesicles, and prostate-only boost to 79...
May 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/26765418/analysis-of-geometric-shifts-and-proper-setup-margin-in-prostate-cancer-patients-treated-with-pelvic-intensity-modulated-radiotherapy-using-endorectal-ballooning-and-daily-enema-for-prostate-immobilization
#20
Songmi Jeong, Jong Hoon Lee, Mi Joo Chung, Sea Won Lee, Jeong Won Lee, Dae Gyu Kang, Sung Hwan Kim
We evaluate geometric shifts of daily setup for evaluating the appropriateness of treatment and determining proper margins for the planning target volume (PTV) in prostate cancer patients.We analyzed 1200 sets of pretreatment megavoltage-CT scans that were acquired from 40 patients with intermediate to high-risk prostate cancer. They received whole pelvic intensity-modulated radiotherapy (IMRT). They underwent daily endorectal ballooning and enema to limit intrapelvic organ movement. The mean and standard deviation (SD) of daily translational shifts in right-to-left (X), anterior-to-posterior (Y), and superior-to-inferior (Z) were evaluated for systemic and random error...
January 2016: Medicine (Baltimore)
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