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https://www.readbyqxmd.com/read/28046755/su-f-j-122-rectal-sparing-reproducibility-in-prostate-cancer-patients-treated-with-hydrogel-spacer-and-proton-therapy
#1
S Hedrick, S Case, B Robison, M Blakey, M Artz, J Renegar, A Schreuder, M Fagundes
PURPOSE: Rectal hydrogel spacer has been shown to improve rectal sparing in prostate radiotherapy. The purpose of this study was to determine the reproducibility of rectal sparing throughout treatment in patients undergoing proton therapy. METHODS: At our facility, prostate cancer patients are treated with pencil beam scanning proton therapy, utilizing an endorectal balloon (ERB) or rectal spacer hydrogel (Gel) "SpaceOAR" implant. All patients were treated with a full bladder and empty rectum (low residue diet and stool softeners)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046335/su-g-jep4-09-impact-of-interfractional-motion-on-hypofractionated-pencil-beam-scanning-proton-therapy-for-prostate-cancer
#2
M Moteabbed, A Trofimov, G Sharp, Y Wang, A Zietman, J Efstathiou, H Lu
PURPOSE: To investigate the impact of anatomy/setup variations on standard vs. hypofractionated anterolateral pencil beam scanning (PBS) proton therapy for prostate cancer. METHODS: Six prostate cancer patients treated with double-scattering proton therapy, who underwent weekly verification CT scans were selected. Implanted fiducials were used for localization, and endorectal balloons for immobilization. New PBS plans using combination of lateral and anterior-oblique (AO) (±35 deg) beams were created...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27929503/real-time-in-vivo-dosimetry-for-sbrt-prostate-treatment-using-plastic-scintillating-dosimetry-embedded-in-a-rectal-balloon-a-case-study
#3
Justin L Cantley, Chee-Wai Cheng, Fredrick B Jesseph, Tarun K Podder, Valdir C Colussi, Bryan J Traughber, Lee E Ponsky
A novel FDA approved in vivo dosimetry device system using plastic scintillating detectors placed in an endorectal balloon to provide real-time in vivo dosimetry for prostatic rectal interface was tested for use with stereotactic body radiotherapy (SBRT). The system was used for the first time ever to measure dose during linear accelerator based SBRT. A single patient was treated with a total dose of 36.25 Gy given in 5 fractions. Delivered dose was measured for each treatment with the detectors placed against the anterior rectal wall near the prostate rectal interface...
November 8, 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27674238/meeting-dose-objectives-in-stereotactic-body-radiation-therapy-for-prostate-cancer-water-versus-air-filled-endorectal-balloon
#4
L Tsvang, A Dubouloz, D Alezra, Z Symon, R Miralbell
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27602248/efficacy-and-safety-of-botulinum-toxin-in-treatment-of-anismus-a-systematic-review
#5
Sameh Hany Emile, Hossam Ayman Elfeki, Hosam Ghazy Elbanna, Mohamed Youssef, Waleed Thabet, Tito M Abd El-Hamed, Basem Said, Ahmed Lotfy
AIM: To evaluate the efficacy and safety of botulinum toxin type A (BTX-A) in the management of patients with anismus. METHODS: An organized search of published literature was conducted using electronic databases including: PubMed/MEDLINE, and Cochrane Central Register of Controlled Trials, also an internet-based search using "Google Scholar" service was conducted. Both comparative and observational studies were included. We excluded irrelevant articles, editorials, case reports, reviews, and meta-analyses...
August 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27307750/analysis-of-prostate-bed-motion-using-an-endorectal-balloon-and-cone-beam-computed-tomography-during-postprostatectomy-radiotherapy
#6
Ji Hyeon Joo, Yeon Joo Kim, Young Seok Kim, Young Pil Cho, Ho Yeon Lee, Chang Young Jeong, Jungwon Kwak, Byung Chul Cho
BACKGROUND: The authors conducted this prospective study to analyze the amount of interfractional prostate bed motion (PBM) and quantify its components with the use of an endorectal balloon (ERB). METHODS: A total of 1,348 cone beam computed tomography images from 46 patients who underwent postprostatectomy radiotherapy were analyzed. For the pilot image, electronic portal imaging, guided by skin marks was performed to ensure proper positioning and inflation of the ERB...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27247058/quantification-of-vaginal-motion-associated-with-daily-endorectal-balloon-placement-during-whole-pelvis-radiotherapy-for-gynecologic-cancers
#7
Nicolette Taku, Joseph Dise, Owen Kenton, Lingshu Yin, Boon-Keng Kevin Teo, Lilie L Lin
BACKGROUND AND PURPOSE: To quantify intra-treatment vaginal motion in women treated with daily endorectal balloon (ERB) placement and external beam radiotherapy for gynecologic cancers. MATERIALS AND METHODS: Eighteen post-hysterectomy women with gynecologic cancers underwent computed tomography (CT) simulation scans and daily treatment with ERB. Fiducial markers were placed at the vaginal apex prior to simulation and patients were counseled on a pre-treatment bladder filling protocol...
May 28, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27222297/two-dimensional-in-vivo-rectal-dosimetry-using-an-endorectal-balloon-with-unfoldable-radiochromic-film-during-prostate-cancer-radiotherapy
#8
Eun Hee Jeang, Soonki Min, Kwan Ho Cho, Ui-Jung Hwang, Sang Hyoun Choi, Jungwon Kwak, Jong Hwi Jeong, Haksoo Kim, Se Byeong Lee, Dongho Shin, Jeonghoon Park, Joo-Young Kim, Dae Yong Kim, Young Kyung Lim
BACKGROUND AND PURPOSE: The present study aims to investigate the feasibility of two-dimensional (2D) in vivo rectal dosimetry using an endorectal balloon for the radiotherapy of prostate cancer. MATERIALS AND METHODS: The endorectal balloon was equipped with an unfoldable radiochromic film. The film was unrolled as the balloon was inflated, and rolled as it was deflated. Its mechanical and imaging properties were tested, and the dosimetric effectiveness was evaluated in clinical photon and proton beams...
August 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27145164/prospective-mri-based-imaging-study-to-assess-feasibility-of-proton-therapy-for-post-prostatectomy-radiation
#9
Samuel Swisher-McClure, Lingshu Yin, Mark Rosen, Sonny Batra, Abigail T Berman, Stefan Both, Neha Vapiwala
PURPOSE/OBJECTIVES: To optimize delivery of post-prostatectomy radiation (PPRT) with protons by examining dosimetric effects of variations in physician contouring, organ motion, and patient alignment during a course of PPRT. MATERIAL AND METHODS: We enrolled 10 patients receiving PPRT in a prospective imaging study. All patients underwent combined computed tomography (CT)/magnetic resonance imaging (MRI) simulation with endorectal balloon (ERB) and received intensity modulated radiation therapy (IMRT) per institutional standards...
July 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27002470/clinical-commissioning-of-an-in-vivo-range-verification-system-for-prostate-cancer-treatment-with-anterior-and-anterior-oblique-proton-beams
#10
M Hoesl, S Deepak, M Moteabbed, G Jassens, J Orban, Y K Park, K Parodi, E H Bentefour, H M Lu
The purpose of this work is the clinical commissioning of a recently developed in vivo range verification system (IRVS) for treatment of prostate cancer by anterior and anterior oblique proton beams. The IRVS is designed to perform a complete workflow for pre-treatment range verification and adjustment. It contains specifically designed dosimetry and electronic hardware and a specific software for workflow control with database connection to the treatment and imaging systems. An essential part of the IRVS system is an array of Si-diode detectors, designed to be mounted to the endorectal water balloon routinely used for prostate immobilization...
April 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/26907917/a-prospective-comparison-of-the-effects-of-interfractional-variations-on-proton-therapy-and-intensity-modulated-radiation-therapy-for-prostate-cancer
#11
RANDOMIZED CONTROLLED TRIAL
Maryam Moteabbed, Alexei Trofimov, Gregory C Sharp, Yi Wang, Anthony L Zietman, Jason A Efstathiou, Hsiao-Ming Lu
PURPOSE: To quantify and compare the impact of interfractional setup and anatomic variations on proton therapy (PT) and intensity modulated radiation therapy (IMRT) for prostate cancer. METHODS AND MATERIALS: Twenty patients with low-risk or intermediate-risk prostate cancer randomized to receive passive-scattering PT (n=10) and IMRT (n=10) were selected. For both modalities, clinical treatment plans included 50.4 Gy(RBE) to prostate and proximal seminal vesicles, and prostate-only boost to 79...
May 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/26765418/analysis-of-geometric-shifts-and-proper-setup-margin-in-prostate-cancer-patients-treated-with-pelvic-intensity-modulated-radiotherapy-using-endorectal-ballooning-and-daily-enema-for-prostate-immobilization
#12
Songmi Jeong, Jong Hoon Lee, Mi Joo Chung, Sea Won Lee, Jeong Won Lee, Dae Gyu Kang, Sung Hwan Kim
We evaluate geometric shifts of daily setup for evaluating the appropriateness of treatment and determining proper margins for the planning target volume (PTV) in prostate cancer patients.We analyzed 1200 sets of pretreatment megavoltage-CT scans that were acquired from 40 patients with intermediate to high-risk prostate cancer. They received whole pelvic intensity-modulated radiotherapy (IMRT). They underwent daily endorectal ballooning and enema to limit intrapelvic organ movement. The mean and standard deviation (SD) of daily translational shifts in right-to-left (X), anterior-to-posterior (Y), and superior-to-inferior (Z) were evaluated for systemic and random error...
January 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26725959/impact-of-the-use-of-an-endorectal-balloon-on-rectal-dosimetry-during-stereotactic-body-radiation-therapy-for-localized-prostate-cancer
#13
Andrew T Wong, David Schreiber, Manuj Agarwal, Aleksey Polubarov, David Schwartz
PURPOSE: Endorectal balloons may be of benefit during stereotactic body radiation therapy of the prostate to limit intrafraction prostatic motion and potentially minimize rectal toxicity. We evaluated the effect of the endorectal balloon (ERB) on rectal dosimetry, specifically the absolute volume of rectum receiving high dose. METHODS AND MATERIALS: Eleven patients with localized prostate cancer underwent stereotactic body radiation therapy planning with computed tomography simulation with and without a RadiaDyne ERB inflated with 60 mL of water...
July 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/26699585/comparison-of-vmat-sabr-treatment-plans-with-flattening-filter-ff-and-flattening-filter-free-fff-beam-for-localized-prostate-cancer
#14
COMPARATIVE STUDY
Jin-Beom Chung, Jae-Sung Kim, Keun-Yong Eom, In-Ah Kim, Sang-Won Kang, Jeong-Woo Lee, Jin-Young Kim, Tae-Suk Suh
The purpose of this study is to investigate the feasibility of using a flattening filter-free (FFF) beam with an endorectal balloon for stereotactic ablative body radiotherapy (SABR) of clinically localized prostate cancer. We assessed plans of SABR with volumetric-modulated arc therapy (VMAT) that used a flattening filter (FF) beam and an FFF beam and compared the verification results of dosimetric quality assurance for all pretreatment plans. A total of 20 patients with prostate cancer were enrolled in the study...
2015: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/26584144/development-and-evaluation-of-a-multichannel-endorectal-rf-coil-for-prostate-mri-at-7t-in-combination-with-an-external-surface-array
#15
M Arcan Ertürk, Jinfeng Tian, Pierre-François Van de Moortele, Gregor Adriany, Gregory J Metzger
PURPOSE: To develop and evaluate a sterilizable multichannel endorectal coil (ERC) for use in combination with an external surface array (ESA) for high-resolution anatomical and functional studies of the prostate at 7T. MATERIALS AND METHODS: A two-loop ERC (ERC-2L) and a microstrip-loop ERC (ERC-ML) were compared at 7T in terms of transmit and receive performance. The best-performing ERC was evaluated alone and in combination with the ESA through 1) simulations on both phantom and an anatomically correct numerical human model to assess B1+ transmit and specific absorption rate (SAR) efficiencies, and 2) phantom experiments to calculate B1+ transmit efficiency and signal-to-noise ratio (SNR)...
June 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/26434692/a-colorimetric-plasmonic-nanosensor-for-dosimetry-of-therapeutic-levels-of-ionizing-radiation
#16
Karthik Pushpavanam, Eshwaran Narayanan, John Chang, Stephen Sapareto, Kaushal Rege
Modern radiation therapy using highly automated linear accelerators is a complex process that maximizes doses to tumors and minimizes incident dose to normal tissues. Dosimeters can help determine the radiation dose delivered to target diseased tissue while minimizing damage to surrounding healthy tissue. However, existing dosimeters can be complex to fabricate, expensive, and cumbersome to operate. Here, we demonstrate studies of a liquid phase, visually evaluated plasmonic nanosensor that detects radiation doses commonly employed in fractionated radiotherapy (1-10 Gy) for tumor ablation...
December 22, 2015: ACS Nano
https://www.readbyqxmd.com/read/26414645/post-transurethral-resection-of-the-prostate-inflation-of-pressure-controlled-endorectal-balloon-impact-on-postoperative-bleeding-a-preliminary-experimental-pilot-study
#17
RANDOMIZED CONTROLLED TRIAL
Khaled Mohyelden, Hamdy Ibrahim, Osman Abdel-Kader, Mahmoud H Sherief, Ahmed El-Nashar, Hosam Shaker, Mohamed A Elkoushy
OBJECTIVE: To evaluate the impact of rectal balloon (RB) inflation on post-transurethral resection of the prostate (TURP) bleeding in patients with symptomatic benign prostatic hyperplasia. METHODS: After institutional review board approval, patients who were eligible for TURP were randomized into two equal groups, depending on whether they received postoperative endorectal balloon (RB) (GII) or not (GI). The tip of three-way Foley catheter was fixed to a balloon by a blaster strip to prepare air-tight RB...
February 2016: Journal of Endourology
https://www.readbyqxmd.com/read/26198131/investigation-of-factors-affecting-hypothermic-pelvic-tissue-cooling-using-bio-heat-simulation-based-on-mri-segmented-anatomic-models
#18
Yuting Lin, Wei-Ching Lin, Peter T Fwu, Tzu-Ching Shih, Lee-Ren Yeh, Min-Ying Su, Jeon-Hor Chen
This study applied a simulation method to map the temperature distribution based on magnetic resonance imaging (MRI) of individual patients, and investigated the influence of different pelvic tissue types as well as the choice of thermal property parameters on the efficiency of endorectal cooling balloon (ECB). MR images of four subjects with different prostate sizes and pelvic tissue compositions, including fatty tissue and venous plexus, were analyzed. The MR images acquired using endorectal coil provided a realistic geometry of deformed prostate that resembled the anatomy in the presence of ECB...
October 2015: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/26103477/in-vivo-endorectal-dosimetry-of-prostate-tomotherapy-using-dual-moskin-detectors
#19
Sarah J Alnaghy, Shrikant Deshpande, Dean L Cutajar, Kemal Berk, Peter Metcalfe, Anatoly B Rosenfeld
Verification of dose to the anterior rectal wall in helical tomotherapy to the prostate is important due to the close proximity of the rectal wall to the treatment field. The steep dose gradient makes these measurements challenging. A phantom-based study was completed, aimed at developing a system for measurement of anterior rectal wall doses during hypofractionated prostate stereotactic body radiotherapy (SBRT) utilizing tomotherapy delivery. An array of four dual MOSkinTM dosimeters, spaced 1 cm apart, was placed on a replica Rectafix® immobilization spacer device...
2015: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/25890071/dosimetric-effects-of-the-acuros-xb-and-anisotropic-analytical-algorithm-on-volumetric-modulated-arc-therapy-planning-for-prostate-cancer-using-an-endorectal-balloon
#20
Taeryool Koo, Jin-Beom Chung, Keun-Yong Eom, Jin-Yong Seok, In-Ah Kim, Jae-Sung Kim
BACKGROUND: To compare the dosimetric effects of Acuros XB (AXB) and Anisotropic Analytical Algorithm (AAA) on volumetric modulated arc therapy (VMAT) planning for postoperative prostate cancer patients irradiated using an endorectal balloon (ERB). METHODS: We measured central axis doses with film in a phantom containing an air cavity, and compared measurements with calculations of the AAA and AXB. For clinical study, 10 patients who had undergone whole pelvic radiotherapy (WPRT) followed by prostatic bed-only radiotherapy (PBRT) using VMAT were enrolled...
2015: Radiation Oncology
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