Carlo Greco, Oriol Pares, Nuno Pimentel, Vasco Louro, Beatriz Nunes, Justyna Kociolek, Joep Stroom, Sandra Vieira, Dalila Mateus, Maria Joao Cardoso, Ana Soares, Joao Marques, Elda Freitas, Graça Coelho, Zvi Fuks
PURPOSE: To explore whether the rectal distension-mediated technique, harnessing human physiology to achieve intrafractional prostate motion mitigation, enables urethra sparing by inverse dose painting, thus promoting dose escalation with extreme hypofractionated stereotactic ablative radiotherapy (SABR) in prostate cancer. MATERIALS AND METHODS: Between June 2013 and December 2018, 444 patients received 5 × 9 Gy SABR over 5 consecutive days. Rectal distension-mediated SABR was employed via insertion of a 150-cm3 air-inflated endorectal balloon...
2022: Frontiers in Oncology