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EBUS-TBNA

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https://www.readbyqxmd.com/read/29020679/a-preclinical-evaluation-comparing-the-performance-of-a-novel-19-g-flexible-needle-to-a-commercially-available-22-g-ebus-tbna-sampling-needle
#1
Kasia Czarnecka-Kujawa, Alain Tremblay, Kazuhiro Yasufuku, Anna Sczaniecka, Sujeeth Parthiban, Lawrence Kunz, David Dillard, Xavier Gonzalez
BACKGROUND: Needle samples may not provide sufficient diagnostic material for the assessment of mediastinal lymph nodes. OBJECTIVE: The study compared the specimen size and diagnostic performance of a new 19-G endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) needle to that of a standard 22-G EBUS-TBNA needle in a swine model of granulomatous lymphadenopathy. METHODS: Granulomatous inflammation was induced in mediastinal lymph nodes (LNs) of 10 domestic swine by injection of talc slurry...
October 12, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28993508/personalized-sirna-nanoparticle-systemic-therapy-using-metastatic-lymph-node-specimens-obtained-with-ebus-tbna-in-lung-cancer
#2
Tatsuya Kato, Daiyoon Lee, Huang Huang, William Cruz-Munoz, Hideki Ujiie, Kosuke Fujino, Hironobu Wada, Priya Patel, Hsin-Pei Hu, Kentaro Hirohashi, Takahiro Nakajima, Masaaki Sato, Mitsuhito Kaji, Kichizo Kaga, Yoshiro Matsui, Juan Chen, Gang Zheng, Kazuhiro Yasufuku
Inhibiting specific gene expression with short interfering RNA (siRNA) provides a new therapeutic strategy to tackle many diseases at the molecular level. Recent strategies called high-density lipoprotein (HDL)-mimicking peptide-phospholipid nanoscaffold (HPPS) nanoparticles have been used to induce siRNAs-targeted delivery to scavenger receptor class B type I receptor (SCARB1) expressing cancer cells with high efficiency. Here, eight ideal therapeutic target genes were identified for advanced lung cancer throughout the screenings using endobronchial ultrasonography-guided transbronchial needle aspiration (EBUS-TBNA) and the establishment of a personalized siRNA-nanoparticle therapy...
October 9, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28976111/contribution-of-cell-blocks-obtained-through-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-for-the-determination-of-lung-cancer-subtypes
#3
Nilgün Yılmaz Demirci, Asiye Uğraş Dikmen, Zarife Abdullayeva, Can Öztürk
INTRODUCTION: It is crucial to diagnose the subtype of lung cancer quickly and accurately for effective therapy. Conventional cytology staining sometimes provides limited information, and additional tissue is often required to diagnose lung cancer. Cell blocks (CB) recovered during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) increases the diagnostic accuracy of the procedure and the likelihood of additional valuable histochemical and immunohistochemical staining...
October 4, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28967732/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-under-conscious-sedation-with-meperidine-and-midazolam
#4
Lorenzo Agostini, Nicola Facciolongo, Mirco Lusuardi, Eleonora Casalini, Carla Galeone, Luciano Lasagni, Luigi Zucchi
Endobronchial Ultrasound guided transbronchial needle aspiration (EBUS-TBNA) is usually performed under general anesthesia or deep sedation with drugs such as Propofol that, at least in Italy, can be administered only by an anesthesiologist. Aim of the study was to assess conscious sedation feasibility, safety and tolerability using Meperidine and Midazolam as administered by Pulmonologist and relevant impact on the efficiency of the sampling procedures.All patients undergoing EBUS-TBNA from February 2013 to July 2014 were examined retrospectively...
July 18, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/28951780/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-combining-with-immunohistochemistry-and-genotype-in-lung-cancer-a-single-center-55-cases-retrospective-study
#5
Aiqun Liu, Liwen Qian, Yi Zhong, Xiaoling Lu, Yongxiang Zhao
OBJECTIVE: The purpose of this study was to evaluate the utility of EBUS-TNA for mediastinal mass or suspected lung cancer patients with mediastinal or hilar lymph node enlarged. Further to investigate the clinical value of EBUS-TBNA combining with immunohistochemistry and genotype in lung cancer. METHODS: A total of 55 patients with mediastinal, and/or hilar lymphadenopathy, and/or mediastinal mass previously detected by CT or PET/CT scan and who underwent EBUS-TBNA...
November 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28927679/-mediastinitis-after-endobronchial-ultrasound-guided-transbronchial-needle-aspiration
#6
D Basille, F De Dominicis, E Magois, C Andrejak, P Berna, V Jounieaux
INTRODUCTION: Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure used for the diagnosis of mediastinal and hilar lymphadenopathy. OBSERVATION: We describe a case of mediastinitis appearing 15 days after an EBUS-TBNA procedure in a 79 years old male patient. The mediastinitis was treated surgically by thoracotomy with a wide excision of infected tissue requiring transplantation of a serratus anterior muscle flap pedicled on a branch of the thoracodorsal artery...
September 16, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28910804/ebus-tbna-can-distinguish-sarcoid-like-side-effect-of-nivolumab-treatment-from-tumor-progression-in-non-small-cell-lung-cancer
#7
Ségolène Lainez, Claire Tissot, Michèle Cottier, Jean-Michel Vergnon
With the expansion of immunotherapy in the treatment of lung cancer, clinicians have to face new clinical pictures and adapt their practice. We report the case of a 69-year-old man diagnosed with non-small cell lung cancer using endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and treated with nivolumab as second-line therapy. After 8 injections of nivolumab, a new CT and PET scan revealed massive growth and increase in metabolism of hilar and mediastinal lymph nodes, whereas the size and metabolism of the left upper lobe lesion were reduced...
September 15, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28898881/performance-of-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-for-the-diagnosis-of-isolated-mediastinal-and-hilar-lymphadenopathy
#8
Chung-Chun Tyan, Tiago Machuca, Kasia Czarnecka, Hyang Mi Ko, Gilda da Cunha Santos, Scott L Boerner, Andrew Pierre, Marcelo Cypel, Tom Waddell, Gail Darling, Marc de Perrot, Shaf Keshavjee, William Geddie, Kazuhiro Yasufuku
BACKGROUND: Although many studies have assessed the diagnostic utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the context of a specific disease, few studies have assessed the overall diagnostic yield, sensitivity, and negative predictive value in patients with isolated mediastinal and hilar lymphadenopathy (IMHL). OBJECTIVE: We evaluated the performance of EBUS-TBNA for diagnosing IMHL in a population with a high prevalence of concurrent or preexisting non-pulmonary malignancy...
2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28881088/ectopic-thyroid-cancer-diagnosed-by-endobronchial-ultrasound-guided-transbronchial-needle-aspiration
#9
Jingwen Hu, Ming Li, Lin Xu
We report a case of papillary carcinoma in a mediastinal ectopic thyroid diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). In this case, the tumor was adjacent to the central airway; therefore, we attempted to perform EBUS-TBNA to obtain specimens for a diagnosis of papillary thyroid carcinoma. Surgical resection was conducted, and histological evaluation of the resected specimen confirmed ectopic papillary thyroid carcinoma, consistent with the histology from the EBUS-TBNA specimen...
September 7, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28879863/a-novel-stepwise-approach-combining-conventional-and-endobronchial-ultrasound-needle-aspiration-for-mediastinal-lymph-node-sampling
#10
Levy Liran, Kuint Rottem, Fridlender Zvi Gregorio, Abutbul Avi, Berkman Neville
BACKGROUND AND OBJECTIVES: Since the introduction of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), most pulmonary centers use this technique exclusively for mediastinal lymph node (LN) sampling. Conventional "blind" TBNA (cTBNA), however, is cheaper, more accessible, provides more tissue, and requires less training. We evaluated whether sampling of mediastinal LN using EBUS-TBNA or cTBNA according to a predefined set of criteria provides acceptable diagnostic yield...
September 7, 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28869237/nasal-route-for-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-ebus-tbna-an-alternative-modality-in-difficult-oral-bronchoscope-insertion
#11
Saurabh Mittal, Karan Madan, Vijay Hadda, Anant Mohan, Randeep Guleria
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is usually performed under moderate sedation through the oral approach. Oral insertion is performed owing to the larger size of the EBUS bronchoscope as well as the delicate and rigid distal end with an integrated ultrasound transducer assembly. Nasal route for EBUS scope insertion has been described as a feasible alternative. We herein report a patient wherein inability to introduce the EBUS bronchoscope through the mouth necessitated nasal insertion of the bronchoscope to successfully perform EBUS-TBNA...
September 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28857362/diagnostic-performance-of-endobronchial-ultrasound-guided-mediastinal-lymph-node-sampling-in-early-stage-non-small-cell-lung-cancer-a-prospective-study
#12
Macarena R Vial, Oisin J O'Connell, Horiana B Grosu, Mike Hernandez, Laila Noor, Roberto F Casal, John Stewart, Mona Sarkiss, Carlos A Jimenez, David Rice, Reza Mehran, David E Ost, George A Eapen
BACKGROUND AND OBJECTIVE: Standard nodal staging of lung cancer consists of positron emission tomography/computed tomography (PET/CT), followed by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) if PET/CT shows mediastinal lymphadenopathy. Sensitivity of EBUS-TBNA in patients with N0/N1 disease by PET/CT is unclear and largely based on retrospective studies. We assessed the sensitivity of EBUS-TBNA in this setting. METHODS: We enrolled patients with proven or suspected lung cancer staged as N0/N1 by PET/CT and without metastatic disease (M0), who underwent staging EBUS-TBNA...
August 30, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28840013/training-and-certification-in-endobronchial-ultrasound-guided-transbronchial-needle-aspiration
#13
REVIEW
Therese Maria Henriette Naur, Lars Konge, Leizl Joy Nayahangan, Paul Frost Clementsen
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) plays a key role in the staging of lung cancer, which is crucial for allocation to surgical treatment. EBUS-TBNA is a complicated procedure and simulation-based training is helpful in the first part of the long learning curve prior to performing the procedure on actual patients. New trainees should follow a structured training programme consisting of training on simulators to proficiency as assessed with a validated test followed by supervised practice on patients...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28834344/unusual-presentation-of-poorly-differentiated-primary-pulmonary-synovial-sarcoma-pd-ppss-diagnosed-by-ebus-tbna-with-cytogenetic-confirmation-a-diagnostic-challenge
#14
Sharvari Dalal, Charles E Nicholson, Darshana Jhala
Poorly differentiated primary pulmonary synovial sarcoma (PD-PPSS) is a rare, aggressive neoplasm, which occurs in 0.5% cases of all lung malignancies. The diagnosis of PD-PPSS can be very challenging on cytology samples. We present here an unusual case of PD-PPSS diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), in the setting of known history of diffuse large B-cell lymphoma. Diff-Quik and Papanicolaou stains showed cellular specimen with clusters of highly atypical small round blue cells admixed with lymphoid elements; and some with denuded cytoplasm...
August 18, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28832765/is-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-with-a-stylet-necessary-for-lymph-node-screening-in-lung-cancer-patients
#15
Y Xu, J Lin, Y Jin, X Wu, H Zheng, J Feng
During endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), a needle is commonly used with a stylet, although recently the stylet has been omitted. This prospective study aimed to compare the quality of specimens obtained by EBUS-TBNA performed with and without a stylet. Between November 2013 and November 2014, 131 patients with lung cancer underwent EBUS-TBNA, with a total of 148 mediastinal or hilar lymph nodes sampled both with and without an inner-stylet, yielding 296 cytological specimens...
August 17, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28819382/effectiveness-of-the-benign-and-malignant-diagnosis-of-mediastinal-and-hilar-lymph-nodes-by-endobronchial-ultrasound-elastography
#16
Haidong Huang, Zhiang Huang, Qin Wang, Xinan Wang, Yuchao Dong, Wei Zhang, Paul Zarogoulidis, Yan-Gao Man, Wolfgang Hohenforst Schmidt, Chong Bai
Background and Objectives: Endobronchial ultrasound elastography is a new technique for describing the stiffness of tissue during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). The aims of this study were to investigate the diagnostic value of Endobronchial ultrasound (EBUS) elastography for distinguishing the difference between benign and malignant lymph nodes among mediastinal and hilar lymph node. Materials and Methods: From June 2015 to August 2015, 47 patients confirmed of mediastinal and hilar lymph node enlargement through examination of Computed tomography (CT) were enrolled, and a total of 78 lymph nodes were evaluated by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28782248/risk-stratification-in-the-investigation-of-pulmonary-nodules-in-a-high-risk-cohort-pet-ct-outperforms-clinical-risk-prediction-algorithms
#17
Glenna Gibson, Aravind Ravi Kumar, Karin Steinke, Farzad Bashirzadeh, Rebecca Roach, Morgan Windsor, Robert Ware, David Fielding
BACKGROUND: Clinical prediction models and 18F-FDG-PET/CT are used for assessment of solitary pulmonary nodules (SPNs) however biopsy is still required before treatment which carries risk. AIM: To determine combined predictive benefit of one such model combined with modern PET/CT data to improve decision making about biopsy prior to treatment and possibly reduce costs. METHOD: Patients with a SPN undergoing 18F-FDG-PET/CT from January 2011-December 2012 were retrospectively identified...
August 7, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28747963/review-of-sarcoidosis-in-a-province-of-south-korea-from-1996-to-2014
#18
Min-Seok Kim, Cheol-Kyu Park, Hong-Joon Shin, Hyeong-Won Seo, Jinsun Chang, Seong Ahn, Tae-Ok Kim, Jung-Hwan Lim, In-Jae Oh, Yong-Soo Kwon, Yu-Il Kim, Sung-Chul Lim, Young-Chul Kim
BACKGROUND: Since the introduction of endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) of mediastinal lymph nodes, the incidence of histopathologically-confirmed sarcoidosis has increased. METHODS: The electronic medical records of Chonnam National University (CNU) Hospital and CNU Hwasun Hospital (CNUHH) were searched for confirmed cases of sarcoidosis diagnosed between 1996 and 2014. Cases were selected using a combination of clinical, radiological, and pathological evidence...
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28727198/morphology-quiz-mediastinal-adenopathy-cytology-from-endobronchial-ultrasound-transbronchial-aspiration-ebus-tbna
#19
D Frankel, A Robaglia-Schlupp, P Roll, E Kaspi
No abstract text is available yet for this article.
July 20, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28712157/training-and-proficiency-in-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-a-systematic-review
#20
REVIEW
Inderpaul S Sehgal, Sahajal Dhooria, Ashutosh N Aggarwal, Ritesh Agarwal
Endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) is currently the modality of choice for evaluation of mediastinal lymphadenopathy. However, there is still uncertainty regarding the training methodology and the number of procedures required to attain proficiency in EBUS. Herein, we performed a systematic review of studies selected from PubMed, EmBase and Scopus databases describing the training and assessment of proficiency during EBUS, specifically studies investigating various methods for training, its outcome and the number of procedures required to overcome the learning curve for EBUS...
November 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
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