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Sarcoma radiotherapy

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https://www.readbyqxmd.com/read/28215838/impact-of-adjuvant-therapy-on-recurrence-patterns-in-stage-i-uterine-carcinosarcoma
#1
Koji Matsuo, Kohei Omatsu, Malcolm S Ross, Marian S Johnson, Mayu Yunokawa, Merieme M Klobocista, Dwight D Im, Stephen H Bush, Yutaka Ueda, Tadao Takano, Erin A Blake, Kosei Hasegawa, Tsukasa Baba, Masako Shida, Shinya Satoh, Takuhei Yokoyama, Hiroko Machida, Sosuke Adachi, Yuji Ikeda, Keita Iwasaki, Takahito M Miyake, Shiori Yanai, Masato Nishimura, Tadayoshi Nagano, Munetaka Takekuma, Satoshi Takeuchi, Tanja Pejovic, Mian Mk Shahzad, Frederick R Ueland, Joseph L Kelley, Lynda D Roman
BACKGROUND: To examine recurrence patterns in women with stage I uterine carcinosarcoma (UCS) stratified by adjuvant therapy pattern. METHODS: We examined 443 cases of stage I UCS derived from a retrospective cohort of 1192 UCS cases from 26 institutions. Adjuvant therapy patterns after primary hysterectomy-based surgery were correlated to recurrence patterns. RESULTS: The most common adjuvant therapy was chemotherapy alone (41.5%) followed by chemotherapy/radiotherapy (15...
February 16, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28214635/secondary-craniofacial-sarcomas-following-retinoblastoma-a-systematic-review
#2
REVIEW
Ryuya Yamanaka, Azusa Hayano
OBJECTIVE: We conducted the largest systematic review of individual patient data to characterize secondary craniofacial sarcomas following retinoblastoma. METHODS: We conducted a systemic search of the PubMed databases, and compiled a comprehensive literature review. Student t-tests were used to evaluate differences between variables. Kaplan-Meier analysis was used to estimate survival. Statistical significance was assessed by using a log-rank test. RESULTS: We analyzed 220 cases of secondary craniofacial sarcomas, including 112 osteosarcomas...
February 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28211936/reduction-of-cyclophosphamide-dose-for-patients-with-subset-2-low-risk-rhabdomyosarcoma-is-associated-with-an-increased-risk-of-recurrence-a-report-from-the-soft-tissue-sarcoma-committee-of-the-children-s-oncology-group
#3
David O Walterhouse, Alberto S Pappo, Jane L Meza, John C Breneman, Andrea Hayes-Jordan, David M Parham, Timothy P Cripe, James R Anderson, William H Meyer, Douglas S Hawkins
BACKGROUND: Failure-free survival (FFS) and overall survival (OS) rates were found to improve on Intergroup Rhabdomyosarcoma Study (IRS) IV (IRS-IV) compared with IRS-III for patients with subset 2 (IRS stage 1, group III nonorbit or stage 3, group I/II) low-risk embryonal rhabdomyosarcoma with the addition of cyclophosphamide (total cumulative cyclophosphamide dose of 26.4 g/m(2) ) to the combination of vincristine and dactinomycin (VAC). The goal of Children's Oncology Group ARST0331 for subset 2 low-risk patients was to reduce the total cumulative cyclophosphamide dose without compromising FFS...
February 17, 2017: Cancer
https://www.readbyqxmd.com/read/28209496/uterine-leiomyosarcoma-epidemiology-contemporary-treatment-strategies-and-the-impact-of-uterine-morcellation
#4
Stephanie Ricci, Rebecca L Stone, Amanda N Fader
Leiomyosarcoma, a rare tumor subtype, accounts for 1% of all uterine malignancies, but contributes to a significant proportion of uterine cancer deaths. Surgery is considered the mainstay of treatment for all soft tissue sarcomas, including uterine variants. However, uterine leiomyosarcoma is challenging to diagnose preoperatively and can mimic the appearance of benign uterine leiomyomas. Recently, concerns have grown in this regard, as surgeons have utilized uterine morcellation and myomectomy procedures unknowingly in the setting of occult uterine sarcoma...
February 13, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28208720/doxorubicin-conjugated-to-glutathione-stabilized-gold-nanoparticles-au-gsh-dox-as-an-effective-therapeutic-agent-for-feline-injection-site-sarcomas-chick-embryo-chorioallantoic-membrane-study
#5
Katarzyna Zabielska-Koczywąs, Izabella Dolka, Magdalena Król, Artur Żbikowski, Wiktor Lewandowski, Józef Mieczkowski, Michał Wójcik, Roman Lechowski
Feline injection-site sarcomas are malignant skin tumours with a high local recurrence rate, ranging from 14% to 28%. The treatment of feline injection-site sarcomas includes radical surgery, radiotherapy and/or chemotherapy. In our previous study it has been demonstrated that doxorubicin conjugated to glutathione-stabilized gold nanoparticles (Au-GSH-Dox) has higher cytotoxic effects than free doxorubicin for feline fibrosarcoma cell lines with high glycoprotein P activity (FFS1, FFS3). The aim of the present study was to assess the effectiveness of intratumoural injection of Au-GSH-Dox on the growth of tumours from the FFS1 and FFS3 cell lines on chick embryo chorioallantoic membrane...
February 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28205183/large-primary-pleural-synovial-sarcoma-with-severe-dyspnea-a-case-report
#6
Minoru Yamaki, Shuji Yonehara, Toshio Noriyuki
BACKGROUND: Synovial sarcoma is a malignant neoplasm of soft tissues. It occurs mainly in the extremities and is closely related to tendons, tendon sheaths, and bursal structures. Primary synovial sarcoma of the pleura and lungs is extremely rare. CASE PRESENTATION: We present the case of a 62-year-old man with a large synovial sarcoma of the left pleura. He presented with general fatigue and severe dyspnea. Chest computed tomography (CT) revealed a 20-cm tumor in the left thoracic cavity...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28203170/primary-ewing-s-sarcoma-of-the-sinonasal-tract-a-case-report
#7
Tomoharu Suzuki, Ryuji Yasumatsu, Torahiko Nakashima, Shuji Arita, Hidetaka Yamamoto, Takashi Nakagawa
A 23-year-old male presented with a 3-month history of left purulent rhinorrhea, progressive nasal obstruction, and intermittent epistaxis. A fiberoptic examination revealed a large vascular polypoid mass completely filling the left nasal cavity. CT and MRI scans showed a large hypervascular mass involving the left nasal airway, maxillary antrum, and the anterior ethmoid cells. There was no bony erosion or contiguous spread, and the remaining sinuses, orbit, and cranial fossa were uninvolved. The patient underwent complete removal of the mass via an external lateral rhinotomy approach...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28202211/the-risk-of-postoperative-complications-and-functional-impairment-after-multimodality-treatment-for-limb-and-trunk-wall-soft-tissue-sarcoma-long-term-results-from-a-monocentric-series
#8
E Stoeckle, A Michot, L Rigal, F Babre, P Sargos, B Henriques de Figueiredo, V Brouste, A Italiano, M Toulmonde, F Le Loarer, M Kind
BACKGROUND AND OBJECTIVES: Conservative surgery for soft-tissue sarcoma (STS) within multimodality treatment attempts to reconcile two contradictory requirements: assuring a good oncological outcome through a wide resection and preserving the function. The aim of our study is to verify whether our conservative approach to STS met these objectives. METHODS: A retrospective database analysis was performed in adults with primary limb or trunk wall STS operated in a single center from 1989 to 2012...
February 3, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28196946/individualised-risk-assessment-for-local-recurrence-and-distant-metastases-in-a-retrospective-transatlantic-cohort-of-687-patients-with-high-grade-soft-tissue-sarcomas-of-the-extremities-a-multistate-model
#9
Julie J Willeumier, Anja J Rueten-Budde, Lee M Jeys, Minna Laitinen, Rob Pollock, Will Aston, P D Sander Dijkstra, Peter C Ferguson, Anthony M Griffin, Jay S Wunder, Marta Fiocco, Michiel A J van de Sande
OBJECTIVES: This study investigates the effect of surgical margins and radiotherapy, in the presence of individual baseline characteristics, on survival in a large population of high-grade soft tissue sarcoma of the extremities using a multistate model. DESIGN: A retrospective multicentre cohort study. SETTING: 4 tertiary referral centres for orthopaedic oncology. PARTICIPANTS: 687 patients with primary, non-disseminated, high-grade sarcoma only, receiving surgical treatment with curative intent between 2000 and 2010 were included...
February 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28188703/the-effect-of-radiation-therapy-in-the-treatment-of-adult-soft-tissue-sarcomas-of-the-extremities-a-long-term-community-based-cancer-center-experience
#10
Jeffrey S Kneisl, Chad Ferguson, Myra Robinson, Anthony Crimaldi, Will Ahrens, James Symanowski, Michael Bates, Jennifer L Ersek, Michael Livingston, Joshua Patt, Edward S Kim
The aim of the study was to determine the effect of external beam radiotherapy (RT) in the treatment of extremity soft tissue sarcoma (STS) before or after limb-sparing surgery (LSS) in a community-based setting. Patients presenting to our institution from 1992 to 2010 and meeting eligibility criteria were stratified into low (G1) or high (G2, G3) pathologic grade and evaluated. Major complication events, including amputation, radiation-induced sarcoma, and pathologic fracture, were assessed. Kaplan-Meier techniques and Cox proportional hazards regression models were used...
February 11, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28182320/proton-beam-therapy-for-bone-sarcomas-of-the-skull-base-and-spine-a-retrospective-nationwide-multicenter-study-in-japan
#11
Yusuke Demizu, Masashi Mizumoto, Tsuyoshi Onoe, Naoki Nakamura, Yasuhiro Kikuchi, Tetsushi Shibata, Tomoaki Okimoto, Sakurai Hideyuki, Tetsuo Akimoto, Kota Ono, Takashi Daimon, Shigeyuki Murayama
We conducted a retrospective, nationwide multicenter study to evaluate the clinical outcomes of proton beam therapy for bone sarcomas of the skull base and spine in Japan. Eligibility criteria included: (1) histologically proven bone sarcomas of the skull base or spine, (2) no metastases, (3) ≥20 years of age, and (4) no prior treatment with radiotherapy. Of the 103 patients treated between January 2004 and January 2012, we retrospectively analyzed data from 96 patients who were followed-up for >6 months or had died within 6 months...
February 9, 2017: Cancer Science
https://www.readbyqxmd.com/read/28176976/the-importance-of-surgery-as-part-of-multimodal-therapy-in-rapid-progressive-primary-extraosseous-ewing-sarcoma-of-the-cervical-intra-and-epidural-space
#12
Richard Bostelmann, Mario Leimert, Hans Jakob Steiger, Kristin Gierga, Athanasios K Petridis
Primary extraosseous Ewing sarcomas (EESs) are an extremely rare pathological entity. Less than 32 cases have been reported in the literature. Here we report an uncommon case with very rapid progression in the cervical region with extra- and intradural involvement. We present a thorough review of the literature and discuss possible treatment modalities. The Medline database was searched using the search terms: Ewing sarcoma, extraosseus tumour, treatment, management, cervical spine. A previously healthy 29-year-old man complained of right-sided radiculopathy (C7)...
October 24, 2016: Clinics and Practice
https://www.readbyqxmd.com/read/28174295/optimizing-local-control-in-high-grade-uterine-sarcoma-adjuvant-vaginal-vault-brachytherapy-as-part-of-a-multimodal-treatment
#13
Pierre Annede, Sébastien Gouy, Renaud Mazeron, Enrica Bentivegna, Pierre Maroun, Claire Petit, Isabelle Dumas, Alexandra Leary, Catherine Genestie, Catherine Lhommé, Eric Deutsch, Philippe Morice, Patricia Pautier, Christine Haie-Meder, Cyrus Chargari
PURPOSE: The phase III European Organization for Research and Treatment of Cancer 55874 study has shown that external beam radiotherapy (EBRT) given as adjuvant treatment decreased locoregional recurrences from 40% to 20% in patients (pts) with localized uterine sarcomas (US). No data exist, however, on the place of brachytherapy (BT). MATERIAL AND METHODS: We conducted a single-center retrospective analysis of pts receiving adjuvant BT of the vaginal vault based on the vaginal mold technique as part of their multimodal adjuvant treatment for a high-grade US from 1985 to 2015...
February 7, 2017: Oncologist
https://www.readbyqxmd.com/read/28173774/treatment-patterns-and-survival-in-an-exhaustive-french-cohort-of-pazopanib-eligible-patients-with-metastatic-soft-tissue-sarcoma-sts
#14
Isabelle Ray-Coquard, Olivier Collard, Françoise Ducimetiere, Mathieu Laramas, Florence Mercier, Nadine Ladarre, Stephanie Manson, Bertrand Tehard, Sébastien Clippe, Jean-Philippe Suchaud, Laetitia Stefani, Jean-Yves Blay
BACKGROUND: The French EMS study prospectively collected exhaustive data from STS patients diagnosed in the Rhone-Alpes region from 2005 to 07. METHODS: The database included diagnosis/histology, surgery, radiotherapy, systemic treatments and treatment response. Treatment patterns and outcomes of patients with metastatic disease, excluding adipocytic sarcoma and GIST were analyzed. RESULTS: Of 888 total patients, 145 were included based on having metastatic disease and appropriate subtypes...
February 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28170118/image-guided-interstitial-high-dose-rate-brachytherapy-in-the-treatment-of-inoperable-recurrent-head-and-neck-malignancies-an-effective-option-of-reirradiation
#15
Nikolaos Tselis, Efstratios Karagiannis, Christos Kolotas, Mehran Baghi, Natasa Milickovic, Nikolaos Zamboglou
BACKGROUND: In recurrent head and neck cancer, therapeutic options are limited and high-quality evidence is rare. The purpose of this report was to present our experience of CT-guided interstitial high-dose rate (HDR) brachytherapy in 4 challenging cases of inoperable recurrent head and neck cancer. METHODS: A 53-year-old man with mucosal melanoma of the paranasal sinuses, a 61-year-old man with myofibroblastic sarcoma of the nasal cavity, a 51-year-old woman with nasopharyngeal cancer, and a 44-year-old woman with orbital leiomyosarcoma were treated with reirradiation by HDR brachytherapy after previous comprehensive therapy, including full course external radiotherapy (RT)...
February 7, 2017: Head & Neck
https://www.readbyqxmd.com/read/28169043/the-value-of-adaptive-preoperative-radiotherapy-in-management-of-soft-tissue-sarcoma
#16
Colleen Dickie, Amy Parent, Anthony M Griffin, Jay Wunder, Peter Ferguson, Peter W Chung, Tim Craig, Michael Sharpe, Nathan Becker, David Shultz, Charles N Catton, Brian O'Sullivan
PURPOSE: To determine the value of preoperative adaptive radiotherapy (ART) for soft tissue sarcoma patients (STS) by modeling the dosimetric consequences of tumour volume changes (TVC) using different external beam radiotherapy techniques. METHODS AND MATERIALS: A subset of 22 STS patients from a recent trial (NCT00188175) underwent a repeat CT scan (CT2) prompted by TVC>1cm during IMRT; 14 tumours grew, 8 shrank. Conformal and conventional plans were modelled in addition to IMRT replicating original criteria from the initial planning dataset (CT1):95% PTV encompassed by 97% prescribed dose...
February 3, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28168937/outcomes-of-spatially-fractionated-radiotherapy-grid-for-bulky-soft-tissue-sarcomas-in-a-large-animal-model
#17
Michael W Nolan, Tracy L Gieger, Alexander A Karakashian, Mariana N Nikolova-Karakashian, Lysa P Posner, Donald M Roback, Judith N Rivera, Sha Chang
GRID directs alternating regions of high- and low-dose radiation at tumors. A large animal model mimicking the geometries of human treatments is needed to complement existing rodent systems (eg, microbeam) and clarify the physical and biological attributes of GRID. A pilot study was undertaken in pet dogs with spontaneous soft tissue sarcomas to characterize responses to GRID. Subjects were treated with either 20 Gy (3 dogs) or 25 Gy (3 dogs), delivered using 6 MV X-rays and a commercial GRID collimator. Acute toxicity and tumor responses were assessed 2, 4, and 6 weeks later...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28167373/extraskeletal-osteosarcoma-a-european-musculoskeletal-oncology-society-study-on-266-patients
#18
A Longhi, S S Bielack, R Grimer, J Whelan, R Windhager, A Leithner, A Gronchi, D Biau, P Jutte, A H Krieg, F M Klenke, G Grignani, D M Donati, R Capanna, J Casanova, C Gerrand, G Bisogno, S Hecker-Nolting, M De Lisa, L D'Ambrosio, M Willegger, G Scoccianti, S Ferrari
PURPOSE: Prognosis of extraskeletal osteosarcoma (ESOS) is reported to be poorer than that of skeletal osteosarcoma. This multicenter retrospective study aimed to evaluate factors influencing ESOS prognosis. PATIENTS AND METHODS: Members of the European Musculoskeletal Oncology Society (EMSOS) submitted institutional data on patients with ESOS. RESULTS: Data from 274 patients treated from 1981 to 2014 were collected from 16 EMSOS centres; 266 patients were eligible...
February 3, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28166791/surgical-management-and-outcome-of-spinal-alveolar-soft-part-sarcoma-aspa-a-case-series-of-five-patients-and-literature-review
#19
Chenglong Zhao, Xin Gao, Jian Yang, Zhenxi Li, Xiaopan Cai, Tao Tan, Tianhui Hou, Wangjun Yan, Xinghai Yang, Cheng Yang, Tielong Liu, Jianru Xiao
BACKGROUND: Alveolar soft part sarcoma (ASPS) is a rare entity of soft tissue malignancies with uncommon spinal involvements. Surgical management should be the best choice of cure. METHODS: Five patients with spinal ASPS were interviewed retrospectively, where data was collected. The relevant literatures were also systematically examined. Thereafter, patient and surgical data were obtained and pooled for prognostic analysis. RESULTS: A total of five patients with eight surgeries were reviewed retrospectively, and three patients previously reported were also included...
February 6, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28157730/successful-treatment-of-classic-kaposi-sarcoma-with-long-pulse-neodymium-doped-yttrium-aluminum-garnet-nd-yag-laser-a-preliminary-study
#20
Mustafa Özdemir, Ali Balevi
BACKGROUND: Kaposi sarcoma (KS) is a systemic disease that can present with cutaneous lesions with or without internal involvement, mostly caused by infection with human herpesvirus-8. The treatment options include surgical excision, cryotherapy, radiotherapy, intralesional chemotherapy, laser, and elastic stockings for the prevention of lymphedema. OBJECTIVE: This article presents 7 cases with classic KS treated with the long-pulse neodymium:yttrium-aluminum-garnet (Nd:YAG) laser...
February 1, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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