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Sarcoma radiotherapy

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https://www.readbyqxmd.com/read/28424084/durable-complete-remission-with-aromatase-inhibitor-therapy-in-a-patient-with-metastatic-uterine-carcinosarcoma-with-poor-performance-status-and-coagulation-disorders-a-case-report
#1
P Martin-Romano, M Jurado, M A Idoate, L Arbea, J L Hernandez-Lizoain, D Cano, J A Paramo, S Martin-Algarra
BACKGROUND: Chemotherapy is considered the most appropriate treatment for metastatic uterine sarcoma, despite its limited efficacy. No other treatment has been conclusively proved to be a real alternative, but some reports suggest that anti-hormonal therapy could be active in a small subset of patients. We report the case of a patient with metastatic uterine carcinosarcoma with positive hormonal receptors and a complete pathological response. CASE PRESENTATION: A 54-year-old white woman presented to our emergency room with hypovolemic shock and serious vaginal bleeding...
April 19, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28422825/interdigitating-dendritic-cell-sarcoma-presenting-in-the-sigmoid-colon-mesentery-a-case-report-and-literature-review
#2
Jianguo Zhu, Sheng Su, Jinfa Zhou, Haige Li
RATIONALE: Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare disease. It commonly occurs in middle-aged males and mainly involves the lymph nodes. Pathological examination plays an important role in differentiating from other tumors, but far less published literature focuses on the imaging characteristics of IDCS. PATIENT CONCERNS: Here, we reported a case of IDCS in a 52-year-old male involving the pelvis with medical imaging and pathologic findings...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28413551/alveolar-soft-part-sarcoma-with-brain-metastases
#3
Vinodh Vayara Perumall, Rahmat Harun, Pulivendhan Sellamuthu, Mohd Shariman Md Shah
Metastatic tumors are the most common mass lesions in the brain. This case reports a rare form of sarcoma with metastasis to the brain. The appropriate management of a patient with metastatic alveolar soft part sarcoma to the brain is discussed. Author describes a 32-year-old gentleman diagnosed with primary tumor at gluteus and distant metastases at lower lobe of right lung and the brain. Histopathology proves diagnosis as alveolar soft part sarcoma. Craniotomy with excision of brain lesion was done. Repeated magnetic resonance imaging of the brain after 2 months showed rapidly growing new lesions...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28405084/primitive-neuroectodermal-tumors-of-the-kidney
#4
Geetha Narayanan, Varun Rajan, T R Preethi
Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) rarely occurs as a primary renal tumor. The disease affects young adults and children and has an aggressive course. The clinical presentation and imaging of these tumors are nonspecific, and they often present at an advanced stage. We present the clinical features, imaging, diagnosis, and treatment of 7 cases of renal PNET (4 men, 3 women; median age, 32 years). Common presenting symptoms were flank or abdominal pain and a mass in the abdomen. On imaging, a large heterogenous infiltrating renal mass with areas of calcification, hemorrhage, and necrosis and tumor thrombus can give a clue to the diagnosis of renal PNET...
April 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28404969/development-of-a-radiosensitivity-gene-signature-for-patients-with-soft-tissue-sarcoma
#5
Zaixiang Tang, Qinghua Zeng, Yan Li, Xinyan Zhang, Jinlu Ma, Mark J Suto, Bo Xu, Nengjun Yi
Adjuvant radiotherapy is an important clinical treatment option for the majority of sarcomas. The motivation of current study is to identify a gene signature and to predict radiosensitive patients who are most likely to benefit from radiotherapy. Using the public available data of soft tissue sarcoma from The Cancer Genome Atlas, we developed a cross-validation procedure for identifying a gene signature and predicting radiosensitive patients through. The result showed that the predicted radiosensitive patients who received radiotherapy had a significantly better survival with a reduced rate of new tumor event and disease progression...
March 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28403089/clinicopathological-characteristics-and-treatment-strategies-for-patients-with-low-grade-endometrial-stromal-sarcoma
#6
Ran Cui, Fang Yuan, Yue Wang, Xia Li, Zhenyu Zhang, Huimin Bai
To investigate and evaluate the clinicopathological characteristics and treatment strategies for patients with low-grade endometrial stromal sarcoma (LG-ESS).The medical records of LG-ESS patients who were treated at 2 cancer referral centers from January 2005 to December 2015 were retrospectively reviewed.Twenty patients with LG-ESS met the inclusion criteria and were included in this analysis. Hysterectomy with bilateral salpingo-oophorectomy was the mainstay of surgery. Lymphadenectomy was performed in 12 (60%) cases, and no positive nodes were identified...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28399336/an-update-on-tumors-of-the-lacrimal-gland
#7
Simon Andreasen, Bita Esmaeli, Sarah Linéa von Holstein, Lauge Hjorth Mikkelsen, Peter Kristian Rasmussen, Steffen Heegaard
Lacrimal gland tumors are rare and constitute a wide spectrum of different entities ranging from benign epithelial and lymphoid lesions to high-grade carcinomas, lymphomas, and sarcomas with large differences in prognosis and clinical management. The symptoms and findings of a lacrimal gland lesion are a growing mass at the site of the lacrimal gland, including displacement of the eyeball, decreased motility, diplopia, and ptosis. Pain is the cardinal symptom of an adenoid cystic carcinoma. Radiological findings characteristically include an oval, well-demarcated mass for benign lesions whereas malignant lesions typically display calcifications, destruction of bone, and invasion of adjacent structures...
March 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28391003/surgery-alone-is-sufficient-therapy-for-children-and-adolescents-with-low-risk-synovial-sarcoma-a-joint-analysis-from-the-european-paediatric-soft-tissue-sarcoma-study-group-and-the-children-s-oncology-group
#8
Andrea Ferrari, Yueh-Yun Chi, Gian Luca De Salvo, Daniel Orbach, Bernadette Brennan, R Lor Randall, M Beth McCarville, Jennifer O Black, Rita Alaggio, Douglas S Hawkins, Gianni Bisogno, Sheri L Spunt
BACKGROUND: Multimodal risk-adapted treatment is used in paediatric protocols for synovial sarcoma (SS). Retrospective analyses suggest that low-risk SS patients can be safely treated with surgery alone, but no prospective studies have confirmed the safety of this approach. This analysis pooled data from the two prospective clinical trials to assess outcomes in SS patients treated with a surgery-only approach and to identify predictors of treatment failure. METHODS: Patients with localised SS enrolled on the European paediatric Soft tissue sarcoma Study Group (EpSSG) NRSTS2005 and on the Children Oncology Group (COG) ARST0332 trials, treated with surgery alone were eligible for this analysis...
April 6, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28382648/characteristics-management-and-outcomes-of-patients-with-follicular-dendritic-cell-sarcoma
#9
Preetesh Jain, Sarah A Milgrom, Keyur P Patel, Loretta Nastoupil, Luis Fayad, Michael Wang, Chelsea C Pinnix, Bouthaina S Dabaja, Grace L Smith, Jun Yu, Shimin Hu, Carlos E Bueso Ramos, Rashmi Kanagal-Shamanna, L Jeffrey Medeiros, Yasuhiro Oki, Nathan Fowler
Dendritic cell sarcomas are rare tumours of antigen presenting cells. Data regarding their biology, management and outcomes are sparse. We analysed 66 patients with follicular dendritic cell sarcoma (FDCS). Six patients also had Castleman disease, 9 had another malignancy and 13 had an autoimmune disease. Fifty-four per cent of patients presented with localized disease and 46% with systemic involvement. The median progression-free (PFS) and overall survival (OS) following frontline therapy was 21 and 50 months, respectively...
April 6, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28377828/paravertebral-well-differentiated-liposarcoma-with-low-grade-osteosarcomatous-component-case-report-with-11-year-follow-up-radiological-pathological-and-genetic-data-and-literature-review
#10
Nicolas Macagno, Stéphane Fuentes, Gonzague de Pinieux, André Maues de Paula, Sébastien Salas, Jean-Camille Mattéi, Charlotte Dupuis, Romain Appay, Alain Aurias, Henry Dufour, Dominique Figarella-Branger, Corinne Bouvier
Despite being one of the most frequent soft-tissue sarcomas, well-differentiated liposarcoma has never been reported near the spine. The authors present the case of a 67-year-old man with progressive history of back pain. Physical examination revealed a mass located within the right paravertebral muscles. MR and CT imaging showed a heavily ossified central mass surrounded by a peripheral fatty component. No connection with the underlying bone was detected on imagery and during surgery. After surgical resection, histopathological examination revealed a tumor harboring combined features of well-differentiated liposarcoma and low-grade osteosarcoma...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28377061/respiratory-gated-bilateral-pulmonary-radiotherapy-for-ewing-s-sarcoma-and-nephroblastoma-in-children-and-young-adults-dosimetric-and-clinical-feasibility-studies
#11
C Demoor-Goldschmidt, S Chiavassa, S Josset, M-A Mahé, S Supiot
PURPOSE: Bilateral pulmonary radiotherapy in children and young adults aims to reduce the recurrence of lung metastases. The radiation field includes liver tissue, which is sensitive to even low radiation doses. We investigated the feasibility of respiratory gating radiotherapy using voluntary deep inspiration breath hold and its toxicity in these patients. PATIENTS AND METHOD: A retrospective clinical review was conducted for all patients who had undergone bilateral pulmonary radiotherapy, with or without deep inspiration breath hold, treated in our institution between October 1999 and May 2012...
April 1, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28376845/rare-adrenal-gland-incidentaloma-an-unusual-ewing-s-sarcoma-family-of-tumor-presentation-and-literature-review
#12
Hui Guo, Shuaiqi Chen, Shukun Liu, Kaixuan Wang, Erpeng Liu, Faping Li, Yuchuan Hou
BACKGROUND: Members of the Ewing's sarcoma family of tumor (ESFT) are malignant neoplasms and rarely observed in the adrenal gland. CASE PRESENTATION: We report an extremely exceptional case of ESFT rising from the adrenal gland in a 57-year-old Chinese man. The patient was hospitalized with abdominal swelling for 2 months. Computed tomography (CT) scan revealed a nearly-circular mass measuring about 8.1 × 10.6 cm in the right adrenal region. The patient underwent right adrenal resection...
April 4, 2017: BMC Urology
https://www.readbyqxmd.com/read/28376587/-epithelioid-sarcoma-with-mesothelial-and-lymphatic-endothelial-differentiation-a-clinicopathologic-analysis-of-10-cases
#13
Z Y Ke, S J Yang
Objective: To investigate the multidirectional differentiation potential in epithelioid sarcoma (ES), with special emphasis on its mesothelial and lymphatic endothelial markers expression. Methods: Ten cases of distal-type ES were included. The clinical, histological, and immunohistochemical(including mesothelial and lymphatic endothelial markers expression)features and follow-up data were evaluated. Results: The patients aged between 8 to 66 years. Five cases were male and five were female. The tumors were located at the palm (2 cases), wrist (3 cases), upper arm (2 cases), poplitealfossa (1 case), lower leg (1 case) and thigh (1 case), respectively...
April 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28371454/tumor-biology-remains-the-main-determinant-of-prognosis-in-retroperitoneal-sarcomas-a-14-year-single-center-experience
#14
Deanna Wan Jie Ng, Grace Hwei Ching Tan, Claramae Shulyn Chia, Soo Khee Chee, Richard Quek, Mohamad Farid, Melissa Ching Ching Teo
AIM: To review our experience in the management of retroperitoneal sarcomas (RPSs) in a single institution, with a predominantly Asian population, and identify associated prognostic factors for overall survival (OS), disease-free survival (DFS) and local recurrence. MATERIALS AND METHODS: All RPSs diagnosed and managed at our center between January 2000 and March 2014 were included. Exclusion criteria included patients whose medical records were untraceable and patients who underwent biopsy but did not undergo resection...
March 30, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28366554/comparative-study-of-the-calculated-risk-of-radiation-induced-cancer-after-photon-and-proton-beam-based-radiosurgery-of-liver-metastases
#15
Gracinda Mondlane, Michael Gubanski, Pehr A Lind, Ana Ureba, Albert Siegbahn
INTRODUCTION: The potential of proton therapy to improve the sparing of the healthy tissue has been demonstrated in several studies. However, even small doses delivered to the organs at risk (OAR) may induce long-term detriments after radiotherapy. In this study, we investigated the possibility to reduce the risk of radiation-induced secondary cancers with intensity modulated proton therapy (IMPT), when used for radiosurgery of liver metastases. MATERIAL AND METHODS: Ten patients, previously treated for liver metastases with photon-beam based stereotactic body radiation therapy (SBRT) were retrospectively planned for radiosurgery with IMPT...
March 30, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28365084/perianal-synovial-sarcoma-treated-postoperatively-with-iodine-125-brachytherapy-technical-details
#16
Susan Tovey, Clare Stannard, Gerrie Maree, Robin Hiscock, Charlie Thomson, Eugenio Panieri, Paul Goldberg
PURPOSE: A 23-year-old lady had an incompletely excised perianal sarcoma. Brachytherapy as the sole treatment, rather than further surgery or external beam radiotherapy, was considered to be the best option with the least morbidity. METHODS AND MATERIALS: Although brachytherapy techniques with iridium-192 for anal and rectal carcinoma are well described using a perianal template, the size of the template was not suitable for a two-plane implant that needed to be in situ for about 4 days...
March 29, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28362929/metastatic-liposarcoma-of-the-skull-base-a-case-report-and-review-of-literature
#17
Nirmeen Zagzoog, Greta Ra, Alex Koziarz, John Provias, Doron Sommer, Saleh A Almenawer, Kesava Reddy
BACKGROUND AND IMPORTANCE: Myxoid liposarcoma is not an uncommon form of sarcoma. However, it usually affects the lower extremity long bones. Scapular involvement is extremely rare, as is a metastasis to the parasellar region. We present a case of liposarcoma of the skull base originating in the scapular region and metastasizing to the sellar and parasellar regions and provide a review of the pertinent literature. CLINICAL PRESENTATION: A 43-year-old female patient diagnosed with left scapular myxoid liposarcoma was treated with surgical resection...
April 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28361070/primary-psoas-sarcoma-causing-malignant-psoas-syndrome-favourable-response-to-radiotherapy
#18
Thomas A McKay, Sarah Bishop, Michael J McKay
Malignant psoas syndrome (MPS) is an uncommon condition first described by Stevens et al. MPS is caused by malignant infiltration of the psoas muscle and adjacent nerves and is characterised by (fixed) flexion deformity of the ipsilateral hip and proximal lumbosacral plexopathy. It has previously been described in relation to metastatic carcinoma, melanoma and liposarcoma, as well as non-Hodgkins lymphoma. We present the case of a 68-year-old woman with a sarcoma arising in the left psoas muscle at the level of L4 who presented with symptoms of MPS...
March 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28360472/management-of-locally-advanced-primary-mediastinal-synovial-sarcoma
#19
Ambarish S Chatterjee, Rajiv Kumar, Nilendu Purandare, Sabita Jiwnani, George Karimundackal, C S Pramesh
Primary mediastinal synovial sarcoma (PMSS) is a relatively rare disease, and patients are treated predominantly with surgery for resectable disease. Management of locally advanced borderline resectable and unresectable PMSS is not only challenging but also lacks standard guidelines. We present three patients with PMSS, who were unresectable or borderline resectable at presentation and were treated with neoadjuvant chemotherapy followed by surgery and postoperative radiotherapy.
March 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28356770/breast-cancer-in-patients-with-li-fraumeni-syndrome-a-case-series-study-and-review-of-literature
#20
Amara G Nandikolla, Sangeetha Venugopal, Jesus Anampa
BACKGROUND: Li-Fraumeni Syndrome (LFS) is a rare disease with autosomal dominant inheritance linked to germline mutations of tumor suppressor gene TP53. These patients are predisposed to malignancies such as sarcoma, breast cancer, leukemia, and other malignancies. Breast cancer, the most common malignancy in adult patients with LFS, has an early-onset presentation and is usually treated as per the guidelines for the general population due to the limited literature about breast cancer in LFS...
2017: Breast Cancer: Targets and Therapy
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