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Sarcoma radiotherapy

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https://www.readbyqxmd.com/read/28914440/olaratumab-in-combination-with-doxorubicin-for-the-treatment-of-advanced-soft-tissue-sarcoma-an-evidence-review-group-perspective-of-a-national-institute-for-health-and-care-excellence-single-technology-appraisal
#1
REVIEW
Irina A Tikhonova, Tracey Jones-Hughes, James Dunham, Fiona C Warren, Sophie Robinson, Peter Stephens, Martin Hoyle
The manufacturer of olaratumab (Lartruvo(®)), Eli Lilly & Company Limited, submitted evidence for the clinical and cost effectiveness of this drug, in combination with doxorubicin, for untreated advanced soft tissue sarcoma (STS) not amenable to surgery or radiotherapy, as part of the National Institute for Health and Care Excellence (NICE) Single Technology Appraisal process. The Peninsula Technology Assessment Group, commissioned to act as the Evidence Review Group (ERG), critically reviewed the company's submission...
September 15, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28912665/multimodal-approach-of-pulmonary-artery-intimal-sarcoma-a-single-institution-experience
#2
S Secondino, V Grazioli, F Valentino, M Pin, A Pagani, A Sciortino, C Klersy, M G Callegari, P Morbini, R Dore, M Paulli, P Pedrazzoli, A M D'armini
INTRODUCTION: Pulmonary artery sarcoma (PAS) is a rare tumor, whose therapeutic approach is mainly based on surgery, either pneumonectomy or pulmonary endarterectomy (PEA). The prognosis reported in published series is very poor, with survival of 1.5 months without any kind of treatment. PATIENTS AND METHODS: From January 2010 to January 2016, 1027 patients were referred to our hospital for symptoms of acute or chronic pulmonary thromboembolic disease. Twelve patients having a confirmed diagnosis of PAS underwent PEA...
2017: Sarcoma
https://www.readbyqxmd.com/read/28904693/-gastrointestinal-stromal-tumors-gist-status-and-news-through-our-experience-on-54-cases-and-review-of-literature
#3
Nezha Taoufiq, Asmaa Naim, Zineb Bouchbika, Nadia Benchekroune, Hassan Jouhadi, Souha Sahraoui, Abdelatif Benider
Tumors Gastrointestinal Stromal "GIST" are a very rare form of digestive tract cancers belonging to the family of sarcomas. The aim of this study is to establish the epidemiological profile, the diagnostic and therapeutic difficulties of this malignancy supported in a developing country. A retrospective study spread over 8 years from January 2002 to March 2010, was conducted at the Department of Radiotherapy and Oncology of Casablanca (Morocco) have collated 54 cases of Gastrointestinal Stromal tumors. The average age of our patients was 55 years...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28901965/anaplastic-gliomas-in-adults-an-update
#4
Cristina Izquierdo, Bastien Joubert, François Ducray
PURPOSE OF REVIEW: The current review summarizes recent advances on the oncogenesis, classification and treatment of adult anaplastic gliomas. RECENT FINDINGS: According to the 2016 WHO classification, three main molecular subgroups of adult diffuse anaplastic gliomas can be distinguished based on the 1p/19q codeletion and isocitrate dehydrogenase (IDH) mutation status. In the future, this classification may be further refined based on the telomerase reverse transcriptase promoter and alpha thalassemia/mental retardation syndrome X-linked mutation status, gene expression, DNA methylation and genomic profiling...
September 8, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28895107/external-beam-radiation-therapy-for-resectable-soft-tissue-sarcoma-a-systematic-review-and-meta-analysis
#5
Markus Albertsmeier, Alexandra Rauch, Falk Roeder, Sandro Hasenhütl, Sebastian Pratschke, Michaela Kirschneck, Alessandro Gronchi, Nina L Jebsen, Philippe A Cassier, Paul Sargos, Claus Belka, Lars H Lindner, Jens Werner, Martin K Angele
PURPOSE: The aim of this study was to evaluate the role of preoperative and postoperative external beam radiation therapy (EBRT) in the treatment of resectable soft tissue sarcomas (STSs) of different tumor locations. METHODS: A systematic literature search was performed to identify studies investigating the effects of EBRT (versus no EBRT) on local recurrence (LR) and overall survival (OS) or comparing different EBRT sequences. Random effects meta-analyses were calculated and presented as cumulative odds ratios (ORs)...
September 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28895087/benefit-of-adjuvant-radiotherapy-for-local-control-distant-metastasis-and-survival-outcomes-in-patients-with-localized-soft-tissue-sarcoma-comparative-effectiveness-analysis-of-an-observational-cohort-study
#6
Florian Posch, Richard Partl, Carmen Döller, Jakob M Riedl, Maria Smolle, Lukas Leitner, Marko Bergovec, Bernadette Liegl-Atzwanger, Michael Stotz, Angelika Bezan, Armin Gerger, Martin Pichler, Karin S Kapp, Herbert Stöger, Andreas Leithner, Joanna Szkandera
BACKGROUND: This study aimed to quantify the benefit of adjuvant radiotherapy (AXRT) for local control, distant metastasis, and long-term survival outcomes in patients with localized soft tissue sarcoma (STS). METHODS: This single-center retrospective observational study enrolled 433 STS patients who underwent surgery with curative intent. An inverse probability of treatment-weighted (IPTW) analysis was implemented to account rigorously for imbalances in prognostic variables between the adjuvant treatment groups...
September 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28894652/double-pedicled-free-deep-inferior-epigastric-perforator-flap-for-the-coverage-of-thigh-soft-tissue-defect
#7
Olimpiu Bota, Nick Spindler, Jeannine Sauber, Emrah Aydogan, Stefan Langer
Soft-tissue defects caused by radiation injury are a challenging task for the reconstructive surgeon, due to the extent of the soft-tissue damage and the associated injuries of the local blood vessels and bone tissue. We present the application of the versatile deep inferior epigastric perforator (DIEP) flap for the coverage of an extended lateral thigh soft-tissue defect after the surgical resection of an undifferentiated pleomorphic high-grade sarcoma, neoadjuvant chemotherapy, and adjuvant chemo- and radiotherapy...
August 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28893028/synovial-sarcoma-of-palmar-aspect-of-hand-and-survival-a-rare-case-report
#8
Tapan Kumar Sahoo, Ipsita Dhal, Saroj Kumar Das, Saroj Kumar Das Majumdar, Dillip Kumar Parida
Synovial sarcomas of the hand are extremely rare entities than most soft tissue sarcomas. The location at finger is further rarer than carpus of the hand. Synovial sarcoma of the hand/finger initially confused with many diagnoses such as myositis, haematoma, synovitis, tendonitis, bursitis, and other inflammatory lesions and therefore needs careful handling of the case with proper evaluation. We report a case of synovial sarcoma of the palmar surface of the right hand at interface of thumb and index finger in a 22-year-old female...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28891799/-paratesticular-sarcoma-with-synchronous-renal-carcinoma
#9
Juan Astigueta, Milagros Abad-Licham, Lenin Fernández, Marisabel Huerta, Juan Terrones, Mariela Pow-Sang
OBJETIVE: Primary undifferentiated pleomorphic sarcoma (UPS) of the testicular tunics is rare, and synchronism with other malignancies of the urinary tract is uncommon, and may complicate the staging and therapeutic approach. We report the case of a patient diagnosed with primary paratesticular UPS with synchronous Renal Carcinoma. METHODS: Patient presenting with intrascrotal tumor who underwent left radical orchiectomy. In staging work up studies a second urologic neoplasia was found in the kidney...
September 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28854066/activity-of-eribulin-in-patients-with-advanced-liposarcoma-demonstrated-in-a-subgroup-analysis-from-a-randomized-phase-iii-study-of-eribulin-versus-dacarbazine
#10
George D Demetri, Patrick Schöffski, Giovanni Grignani, Jean-Yves Blay, Robert G Maki, Brian A Van Tine, Thierry Alcindor, Robin L Jones, David R D'Adamo, Matthew Guo, Sant Chawla
Purpose A phase III study comparing eribulin with dacarbazine in patients with advanced liposarcoma (LPS) or leiomyosarcoma showed a significant improvement in overall survival (OS) for the eribulin arm, with a manageable toxicity profile. We now report the histology-specific subgroup analysis of the efficacy and safety of eribulin compared with dacarbazine in patients with LPS, an independently randomized stratified subgroup of this phase III trial. Methods Patients ≥ 18 years with advanced or metastatic dedifferentiated, myxoid/round cell, or pleomorphic LPS incurable by surgery or radiotherapy were included...
August 30, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28845531/radical-chest-wall-resection-and-hyperfractionated-accelerated-radiotherapy-for-radiation-associated-angiosarcoma-of-the-breast-a-safe-and-effective-treatment-strategy
#11
Elysia K Donovan, Thomas Corbett, Jasmin Vansantvoort, Ipshita Kak, Snezana Popvic, Barbara Heller
Radiation-associated angiosarcomas (RAS) of the breast are vascular tumors arising in a previous radiation field for primary breast cancer. They occur rarely but confer a high probability of local recurrence (LR) and poor prognosis. A wide range of treatment strategies exists due to limited evidence, and although resection is the definitive treatment, LR rates remain high. It has been suggested hyperfractionated accelerated radiotherapy (HART) has the potential to prevent LR. The sarcoma group at the Juravinski Cancer Centre (JCC) reports our experience of nine patients treated with radical resection and adjuvant HART...
August 27, 2017: Breast Journal
https://www.readbyqxmd.com/read/28844593/alveolar-soft-part-sarcoma-of-orbit-a-rare-diagnosis
#12
Pritee B Chaudhari, Sushmita Pathy, Suryanarayana S V Deo, Bhavna Chawla, Asit Ranjan Mridha
OBJECTIVE: Alveolar soft part sarcoma (ASPS) is an aggressive, rare tumour with unique morphological and histopathological features. METHODS: We report a rare case of orbital ASPS and its management in a young male who presented with painless proptosis and progressive loss of vision. RESULT: Twenty-two year male presented with a history of gradually increasing proptosis with loss of vision since 12months. He underwent radical re-excision of mass with right orbital exenteration and reconstruction using temporalis muscle flap...
August 22, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28842782/optimal-post-operative-radiation-after-soft-tissue-sarcoma-resection-is-achieved-in-less-than-two-thirds-of-cases
#13
Laurent Casabianca, Sarah Kreps, Sylvie Helfre, Martin Housset, Philippe Anract, David J Biau
PURPOSE: Local control of soft tissue sarcomas frequently involves adjuvant radiation to the surgical resection. When opting for post-operative radiation, care should be taken that radiation is started within some reasonable time after the surgery. We were interested to the proportion of patients who did not recieve optimal post-operative radiation and the variables associated. METHODS: We retrospectively analyzed a series of 77 patients operated on for an extremity soft-tissue sarcoma and due for post-operative radiotherapy...
August 25, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28838212/prediction-of-local-and-metastatic-recurrence-in-solitary-fibrous-tumor-construction-of-a-risk-calculator-in-a-multicenter-cohort-from-the-french-sarcoma-group-fsg-database
#14
S Salas, N Resseguier, J Y Blay, A Le Cesne, A Italiano, C Chevreau, P Rosset, N Isambert, P Soulie, D Cupissol, C Delcambre, J O Bay, P Dubray-Longeras, M Krengli, B De Bari, S Villa, J H A M Kaanders, S Torrente, D Pasquier, J O Thariat, L Myroslav, C V Sole, H F Dincbas, J Y Habboush, T Zilli, T Dragan, K Khan R, G Ugurluer, T Cena, F Duffaud, N Penel, F Bertucci, D Ranchere-Vince, P Terrier, S Bonvalot, N Macagno, C Lemoine, M Lae, J M Coindre, C Bouvier
Background: Solitary fibrous tumors (SFT) are rare unusual ubiquitous soft tissue tumors that are presumed to be of fibroblastic differentiation. At present, the challenge is to establish accurate prognostic factors. Patients and methods: A total of 214 consecutive patients with SFT diagnosed in 24 participating cancer centers were entered into the European database (www.conticabase.org) to perform univariate and multivariate analysis for overall survival (OS), local recurrence incidence (LRI) and metastatic recurrence incidence (MRI) by taking competing risks into account...
August 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28826283/radiotherapy-and-hyperthermia-with-curative-intent-in-recurrent-high-risk-soft-tissue-sarcomas
#15
Franziska Eckert, Lore Helene Braun, Frank Traub, Hans-Georg Kopp, Bence Sipos, Ulf Lamprecht, Arndt-Christian Müller, Frank Paulsen, Daniel Zips
PURPOSE: Radiotherapy before or after resection is one of the pillars of treatment for localised high risk soft tissue sarcomas. Treatment intensification has been described with concurrent chemotherapy and hyperthermia. The aim of this study is to assess local control after multimodal treatment, focussing on the treatment of local recurrences after surgery only. PATIENTS AND METHODS: Of 42 patients treated in a prospective protocol with radiotherapy and hyperthermia, nine were treated for isolated local recurrences without metastatic spread...
August 21, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28818569/two-cases-of-pelvic-sarcoma-in-the-acetabulum-with-10-year-follow-ups-after-carbon-ion-radiotherapy
#16
Katsuhisa Kawanami, Toshihiro Matsuo, Keiji Sato, Reiko Imai, Mitsuhiro Kamiya, Norimitsu Wakao, Atsuhiko Hirasawa, Masataka Deie
No abstract text is available yet for this article.
August 14, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28815184/evaluation-of-risk-factors-for-vertebral-compression-fracture-after-carbon-ion-radiotherapy-for-primary-spinal-and-paraspinal-sarcoma
#17
Yoshihiro Matsumoto, Makoto Shinoto, Makoto Endo, Nokitaka Setsu, Keiichiro Iida, Jun-Ichi Fukushi, Kenichi Kawaguchi, Seiji Okada, Hirofumi Bekki, Reiko Imai, Tadashi Kamada, Yoshiyuki Shioyama, Yasuharu Nakashima
BACKGROUND AND PURPOSE: Carbon-ion radiotherapy (C-ion RT) was effective therapy for inoperable spinal and paraspinal sarcomas. However, a significant adverse event following radiotherapies is vertebral compression fractures (VCFs). In this study, we investigated the incidence of and risk factors for post-C-ion RT VCFs in patients with spinal or paraspinal sarcomas. MATERIAL AND METHODS: Thirty consecutive patients with spinal or paraspinal sarcomas treated with C-ion RT were retrospectively reviewed...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28804012/incidence-of-second-malignancy-after-successful-treatment-of-limited-stage-small-cell-lung-cancer-and-its-effects-on-survival
#18
Miho Kono, Pamela K Allen, Steven H Lin, Xiong Wei, Melenda Jeter, James W Welsh, James D Cox, Ritsuko Komaki
INTRODUCTION: Extended survival outcomes from improved treatments for patients with cancer come with an increased risk of developing a metachronous second malignancy (MSM). We evaluated the incidence of MSM after successful treatment of SCLC and compared survival between SCLC patients who developed MSM and those who did not. METHODS: Selection criteria were a diagnosis of limited-stage SCLC and receipt of ≥45 Gy radiotherapy and chemotherapy at a single institution in 1985-2012...
August 10, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28802390/pediatric-head-and-neck-bone-sarcomas-an-analysis-of-204-cases
#19
Jacob S Brady, Sei Y Chung, Emily Marchiano, Jean Anderson Eloy, Soly Baredes, Richard Chan Woo Park
OBJECTIVES: To analyze the demographics, survival, and treatment efficacy of pediatric sarcomas of the facial skeleton and skull. METHODS: Retrospective study of cases from the US National Cancer Institute's Surveillance, Epidemiology, and End Results database. Pediatric patients between the ages of 0 and 18 diagnosed with a malignant sarcoma of either the mandible or the bones of skull, face, and associated joints from 1973 to 2013 were studied. RESULTS: In total, 204 patients were included in the analysis...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28801332/acute-myeloid-leukaemia-masquerading-as-a-primary-cns-tumour
#20
Branko Cuglievan, Brian A Menegaz, Sofia Garces, Michael E Rytting
In children with newly diagnosed acute myeloid leukaemia (AML), myeloid sarcomas (MS) of the central nervous system (CNS) are rare. Since MS involving the CNS are potentially curable, timely recognition is paramount. Establishing a diagnosis may be problematic as they can easily mimic primary CNS neoplasms. We report the case of a 5-year-old boy with AML with t(8;21)(q22;q22) rearrangement who presented with a massive intracranial MS and rapid clinical deterioration suggestive of a meningioma or a primitive neuroectodermal tumour...
August 11, 2017: BMJ Case Reports
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