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https://www.readbyqxmd.com/read/27914298/effects-of-environmental-noise-exposure-on-dna-methylation-in-the-brain-and-metabolic-health
#1
Liqiong Guo, Peng-Hui Li, Hua Li, Elena Colicino, Silvia Colicino, Yi Wen, Ruiping Zhang, Xiaotian Feng, Timothy M Barrow, Akin Cayir, Andrea A Baccarelli, Hyang-Min Byun
Environmental noise exposure is associated with adverse effects on human health including hearing loss, heart disease, and changes in stress-related hormone levels. Alteration in DNA methylation in response to environmental exposures is a well-known phenomenon and it is implicated in many human diseases. Understanding how environmental noise exposures affect DNA methylation patterns may help to elucidate the link between noise and adverse effects on health. In this pilot study we examined the effects of environmental noise exposure on DNA methylation of genes related to brain function and investigated whether these changes are related with metabolic health...
November 30, 2016: Environmental Research
https://www.readbyqxmd.com/read/27913104/d-ala2-gip-glu-pal-is-neuroprotective-in-a-chronic-parkinson-s-disease-mouse-model-and-increases-bndf-expression-while-reducing-neuroinflammation-and-lipid-peroxidation
#2
Yanwei Li, WeiZhen Liu, Lin Li, Christian Hölscher
Type 2 diabetes mellitus (T2DM) is a risk factor for Parkinson's disease (PD). Therefore, treatment to improve insulin resistance in T2DM may be useful for PD patients. Glucose dependent insulinotropic polypeptide (GIP) is a member of the incretin hormone family that can promote insulin release and improve insulin resistance. Several GIP analogues have been developed as potential treatments for T2DM. We had shown previously that D-Ala2-GIP-glu-PAL, a novel long-acting GIP analogue, can play a neuroprotective role in the PD mouse model induced by acute MPTP injection...
November 29, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27886020/cranial-electrotherapy-stimulation-affects-mood-state-but-not-levels-of-peripheral-neurotrophic-factors-or-hypothalamic-pituitary-adrenal-axis-regulation
#3
Hee-Tae Roh, Wi-Young So
Cranial electrotherapy stimulation (CES) is reported to aid in relieving symptoms of depression and anxiety, though the mechanism underlying this effect remains unclear. Therefore, the present study aimed to evaluate changes in the hypothalamic-pituitary-adrenal (HPA) axis response and levels of neurotrophic factors, as well as changes in mood state, in patients undergoing CES therapy. Fifty healthy postmenopausal women were randomly assigned to either a Sham CES group (n = 25) or an Active CES group (n = 25)...
November 18, 2016: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/27870444/sex-differences-and-estrogen-regulation-of-bdnf-gene-expression-but-not-propeptide-content-in-the-developing-hippocampus
#4
Katherine E Kight, Margaret M McCarthy
Sex differences in adult brain function are frequently determined developmentally through the actions of steroid hormones during sensitive periods of prenatal and early postnatal life. In rodents, various cellular end points of the developing brain are affected by estradiol that is derived from the aromatization of circulating testosterone and/or synthesized within the brain. We have previously described a sex difference in neurogenesis in the hippocampus of neonatal rats that is modulated by estradiol. In this report, we examined a potential downstream regulator of the effects of estradiol on hippocampal cell proliferation by measuring gene expression of brain-derived neurotrophin (BDNF) in male and female neonatal rats in response to estradiol...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27870419/sex-differences-in-brain-derived-neurotrophic-factor-signaling-and-functions
#5
REVIEW
Chi Bun Chan, Keqiang Ye
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family that plays a critical role in numerous neuronal activities. Recent studies have indicated that some functions or action mechanisms of BDNF vary in a sex-dependent manner. In particular, BDNF content in some brain parts and the tendency to develop BDNF deficiency-related diseases such as depression are greater in female animals. With the support of relevant studies, it has been suggested that sex hormones or steroids can modulate the activities of BDNF, which may account for its functional discrepancy in different sexes...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27870405/sex-differences-in-brain-derived-neurotrophic-factor-signaling-functions-and-implications
#6
REVIEW
Yi-Chao Wei, Shao-Ran Wang, Xiao-Hong Xu
Brain-derived neurotrophic factor (BDNF) regulates diverse processes such as neuronal survival, differentiation, and plasticity. Accumulating evidence suggests that molecular events that direct sexual differentiation of the brain interact with BDNF signaling pathways. This Mini-Review first examines potential hormonal and epigenetic mechanisms through which sex influences BDNF signaling. We then examine how sex-specific regulation of BDNF signaling supports the development and function of sexually dimorphic neural circuits that underlie male-specific genital reflexes in rats and song production in birds...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27789212/multi-modal-exercise-training-and-protein-pacing-enhances-physical-performance-adaptations-independent-of-growth-hormone-and-bdnf-but-may-be-dependent-on-igf-1-in-exercise-trained-men
#7
Stephen J Ives, Chelsea Norton, Vincent Miller, Olivia Minicucci, Jake Robinson, Gabe O'Brien, Daniela Escudero, Maia Paul, Caitlin Sheridan, Kathryn Curran, Kayla Rose, Nathaniel Robinson, Feng He, Paul J Arciero
OBJECTIVE: Protein-pacing (P; 5-6meals/day @ 2.0g/kgBW/day) and multi-mode exercise (RISE; resistance, interval, stretching, endurance) training (PRISE) improves muscular endurance, strength, power and arterial health in exercise-trained women. The current study extends these findings by examining PRISE on fitness, growth hormone (GH), insulin-like growth factor-1 (IGF-1), and brain-derived neurotrophic factor (BDNF) response, cardiometabolic health, and body composition in exercise-trained men...
October 15, 2016: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/27785749/revealing-the-neuroendocrine-response-after-remoxipride-treatment-using-multi-biomarker-discovery-and-quantifying-it-by-pk-pd-modeling
#8
Willem J van den Brink, Yin C Wong, Berfin Gülave, Piet H van der Graaf, Elizatbeth C M de Lange
To reveal unknown and potentially important mechanisms of drug action, multi-biomarker discovery approaches are increasingly used. Time-course relationships between drug action and multi-biomarker profiles, however, are typically missing, while such relationships will provide increased insight in the underlying body processes. The aim of this study was to investigate the effect of the dopamine D2 antagonist remoxipride on the neuroendocrine system. Different doses of remoxipride (0, 0.7, 5.2, or 14 mg/kg) were administered to rats by intravenous infusion...
October 26, 2016: AAPS Journal
https://www.readbyqxmd.com/read/27742460/behavioural-and-neurochemical-consequences-of-chronic-gut-microbiota-depletion-during-adulthood-in-the-rat
#9
A E Hoban, R D Moloney, A V Golubeva, K A McVey Neufeld, O O'Sullivan, E Patterson, C Stanton, T G Dinan, G Clarke, J F Cryan
Gut microbiota colonization is a key event for host physiology that occurs early in life. Disruption of this process leads to altered brain development which ultimately manifests as changes in brain function and behaviour in adulthood. Studies using germ-free (GF) mice highlight the extreme impact on brain health that results from life without commensal microbes. However, the impact of microbiota disturbances occurring in adulthood is less studied. To this end, we depleted the gut microbiota of 10-week-old male SpragueDawley rats via chronic antibiotic treatment...
December 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27660699/sex-related-factors-influence-expression-of-mood-related-genes-in-the-basolateral-amygdala-differentially-depending-on-age-and-stress-exposure
#10
Rachel Puralewski, Georgia Vasilakis, Marianne L Seney
BACKGROUND: Women are twice as likely to be diagnosed with major depressive disorder (MDD) compared to men, but the molecular mechanisms underlying this sex difference are unclear. Previous studies in the human postmortem brain suggest dysfunction in basolateral amygdala (BLA) inhibitory gamma-aminobutyric acid (GABA) signaling and brain-derived neurotrophic factor (BDNF) function, specifically in females with MDD. METHODS: We investigated the effects of sex chromosome complement, developmental gonadal sex, and circulating testosterone on expression of 3 GABA-related and 2 BDNF-related genes in the BLA using three cohorts of four core genotypes (FCG) mice...
2016: Biology of Sex Differences
https://www.readbyqxmd.com/read/27560704/sleep-extension-increases-igf-i-concentrations-before-and-during-sleep-deprivation-in-healthy-young-men
#11
Mounir Chennaoui, Pierrick J Arnal, Catherine Drogou, Fabien Sauvet, Danielle Gomez-Merino
Sleep deprivation is known to suppress circulating trophic factors such as insulin-like growth factor (IGF)-I and brain-derived neurotrophic factor (BDNF). This experiment examined the effect of an intervention involving 6 nights of extended sleep before total sleep deprivation on this catabolic profile. In a randomized crossover design, 14 young men (age range: 26-37 years) were either in an extended (EXT; time in bed: 2100-0700 h) or habitual (HAB: 2230-0700 h) sleep condition, followed by 3 days in the laboratory with blood sampling at baseline (B), after 24 h of sleep deprivation (24h-SD), and after 1 night of recovery sleep (R)...
September 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27506204/neuroprotective-neurotrophic-and-anti-oxidative-role-of-bacopa-monnieri-on-cus-induced-model-of-depression-in-rat
#12
Sourav Kumar, Amal Chandra Mondal
Major depression is a life threatening neuropsychiatric disorder that produces mental illness and major cause of morbidity. The present study was conducted to evaluate the neuroprotective, neurotrophic and antioxidant potential of Bacopa monnieri extract (BME) on chronic unpredictable stress (CUS) induced behavioral depression in rats. Behavioral tests were carried out for investigation of antidepressant like effects of BME, and potential mechanism was assessed by determining neurotrophin level and hippocampal neurogenesis...
August 10, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27497606/ethanol-induced-changes-in-poly-adp-ribose-polymerase-and-neuronal-developmental-gene-expression
#13
David P Gavin, Handojo Kusumo, Rajiv P Sharma, Marina Guizzetti
Prenatal alcohol exposure has profound effects on neuronal growth and development. Poly-ADP Ribose Polymerase (PARP) enzymes are perhaps unique in the field of epigenetics in that they directly participate in histone modifications, transcription factor modifications, DNA methylation/demethylation and are highly inducible by ethanol. It was our hypothesis that ethanol would induce PARP enzymatic activity leading to alterations in neurodevelopmental gene expression. Mouse E18 cortical neurons were treated with ethanol, PARP inhibitors, and nuclear hormone receptor transcription factor PPARγ agonists and antagonists...
November 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27475493/preimplantation-maternal-stress-impairs-embryo-development-by-inducing-oviductal-apoptosis-with-activation-of-the-fas-system
#14
Liang-Liang Zheng, Xiu-Wen Tan, Xiang-Zhong Cui, Hong-Jie Yuan, Hong Li, Guang-Zhong Jiao, Chang-Li Ji, Jing-He Tan
STUDY QUESTION: What are the mechanisms by which the preimplantation restraint stress (PIRS) impairs embryo development and pregnancy outcome? SUMMARY ANSWER: PIRS impairs embryo development by triggering apoptosis in mouse oviducts and embryos, and this involves activation of the Fas system. WHAT IS KNOWN ALREADY: Although it is known that the early stages of pregnancy are more vulnerable than later stages to prenatal stress, studies on the effect of preimplantation stress on embryo development are limited...
July 29, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27473941/reduced-serum-concentrations-of-brain-derived-neurotrophic-factor-bdnf-in-transsexual-brazilian-men
#15
Anna Martha Vaitses Fontanari, Angelo Brandelli Costa, Bianca Aguiar, Cíntia Tusset, Tahiana Andreazza, Maiko Schneider, Eduarda Dias da Rosa, Bianca Machado Borba Soll, Karine Schwarz, Dhiordan Cardoso da Silva, André Oliveira Borba, Andressa Mueller, Raffael Massuda, Maria Inês Rodrigues Lobato
Serum BDNF levels are significantly decreased in transsexual Brazilian women when compared to cis-sexual men. Since transsexual men are also exposed to chronic social stress and have a high prevalence of associated psychopathologies, it is plausible to inquire if BDNF serum levels are altered in transsexual men as well. Therefore, our objective was to evaluate differences in BDNF serum level of transsexual men when compared to cis-sexual men and women. Our sample comprises 27 transsexual men, 31 cis-sexual women and 30 cis-sexual men recruited between 2011 and 2015...
September 6, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27455847/alterations-in-the-corticotropin-releasing-hormone-crh-neurocircuitry-insights-into-post-stroke-functional-impairments
#16
P Barra de la Tremblaye, H Plamondon
Although it is well accepted that changes in the regulation of the hypothalamic-pituitary adrenal (HPA) axis may increase susceptibility to affective disorders in the general population, this link has been less examined in stroke patients. Yet, the bidirectional association between depression and cardiovascular disease is strong, and stress increases vulnerability to stroke. Corticotropin-releasing hormone (CRH) is the central stress hormone of the HPA axis pathway and acts by binding to CRH receptors (CRHR) 1 and 2, which are located in several stress-related brain regions...
July 2016: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/27397110/preventative-treatment-in-an-animal-model-of-adhd-behavioral-and-biochemical-effects-of-methylphenidate-and-its-interactions-with-ovarian-hormones-in-female-rats
#17
Jodi L Lukkes, Nadja Freund, Britta S Thompson, Shirisha Meda, Susan L Andersen
Clinical and preclinical studies on attention deficit hyperactivity disorder (ADHD) show that juvenile males that are exposed to methylphenidate (MPH) show reduced risk for substance use later in life. In contrast, little is known about whether females have the same enduring treatment response to stimulants and how gonadal hormones influence their behavior later in life. Females received either a sham or 6-hydroxydopamine (6-OHDA) microinjection in the prefrontal cortex (PFC) at postnatal day (P)10. Subjects were then treated with Vehicle or MPH (2mg/kg, p...
September 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27375434/long-term-estrogen-receptor-beta-agonist-treatment-modifies-the-hippocampal-transcriptome-in-middle-aged-ovariectomized-rats
#18
Miklós Sárvári, Imre Kalló, Erik Hrabovszky, Norbert Solymosi, Annie Rodolosse, Zsolt Liposits
Estradiol (E2) robustly activates transcription of a broad array of genes in the hippocampal formation of middle-aged ovariectomized rats via estrogen receptors (ERα, ERβ, and G protein-coupled ER). Selective ERβ agonists also influence hippocampal functions, although their downstream molecular targets and mechanisms are not known. In this study, we explored the effects of long-term treatment with ERβ agonist diarylpropionitrile (DPN, 0.05 mg/kg/day, sc.) on the hippocampal transcriptome in ovariectomized, middle-aged (13 month) rats...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27364961/depression-like-adult-behaviors-may-be-a-long-term-result-of-experimental-pneumococcal-meningitis-in-wistar-rats-infants
#19
Tatiana Barichello, Lutiana R Simões, Jaqueline S Generoso, Vladislav S Sharin, Lucas B Souza, Luciano K Jornada, Diogo Dominguini, Samira S Valvassori, Antônio Lucio Teixeira, João Quevedo
Pneumococcal meningitis is a life-threatening infection of the central nervous system (CNS) with a high mortality rate. In addition to causing severe neurological sequelae infectious diseases of the CNS can play a significant role in the pathogenesis of neuropsychiatric disorders. In this study infant Wistar rats, postnatal day 11, received intracerebroventricular (i.c.v.) either artificial cerebrospinal fluid (CSF) or a Streptococcus pneumoniae suspension to a concentration of 1 × 10(6) colony-forming units (CFU)...
June 30, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27357856/vitamin-d-deficiency-might-pose-a-greater-risk-for-apoe%C3%A9-4-non-carrier-alzheimer-s-disease-patients
#20
Erdinç Dursun, Merve Alaylıoğlu, Başar Bilgiç, Haşmet Hanağası, Ebba Lohmann, Irem L Atasoy, Esin Candaş, Ömür Selin Araz, Burak Önal, Hakan Gürvit, Selma Yılmazer, Duygu Gezen-Ak
Vitamin D is a secosteroid hormone that shares a synthetic pathway with cholesterol. ApoE, which is involved in the transport of cholesterol, is the most significant genetic risk factor for sporadic Alzheimer's disease (AD). Surprisingly, recent studies have indicated the presence of an evolutionary juncture between these two molecules. To demonstrate this possible relationship, we investigated serum levels of 25-hydroxyvitamin-D3 (25OHD) in patients with early onset-AD (EOAD; n:22), late onset-AD (LOAD; n:72), mild cognitive impairment (MCI; n:32) and in healthy subjects (n:70)...
October 2016: Neurological Sciences
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