Weishuai Liu, Xiaozhou Yu, Yudong Yuan, Yixing Feng, Chao Wu, Chongbiao Huang, Peng Xie, Shengnan Li, Xiaofeng Li, Ziyang Wang, Lisha Qi, Yanan Chen, Lei Shi, Mulin Jun Li, Zhiyong Huang, Bo Tang, Antao Chang, Jihui Hao
CD73, a cell surface-bound nucleotidase, facilitates extracellular adenosine formation by hydrolyzing 5'-AMP to adenosine. Several studies have shown that CD73 plays an essential role in immune escape, cell proliferation and tumor angiogenesis, making it an attractive target for cancer therapies. However, there are limited clinical benefits associated with the mainstream enzymatic inhibitors of CD73, suggesting that the mechanism underlying the role of CD73 in tumor progression is more complex than anticipated, and further investigation is necessary...
February 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)