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diclofenac and pancreatitis

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https://www.readbyqxmd.com/read/28734720/rectal-nonsteroidal-anti-inflammatory-drugs-administration-is-effective-for-the-prevention-of-post-ercp-pancreatitis-an-updated-meta-analysis-of-randomized-controlled-trials
#1
Chong Yang, Yanting Zhao, Wentao Li, Shikai Zhu, Hongji Yang, Yu Zhang, Xi Liu, Nan Peng, Ping Fan, Xin Jin
BACKGROUND: Acute pancreatitis is one of the most common complications of endoscopic retrograde cholangiopancreatography (ERCP). Whether the prophylactic administration of rectal non-steroidal anti-inflammatory drugs (NSAIDs) peri-ERCP is effective in preventing post-ERCP pancreatitis (PEP) remains controversial. The aim of this study was to assess the effect of rectal NSAIDs on PEP. METHODS: A systematic search of literature databases (Cochrane Library, PubMed, EMBASE, and Web of Science) was performed to identify eligible randomized controlled trials (RCTs)...
July 17, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28542719/ibuprofen-and-diclofenac-treatments-reduce-proliferation-of-pancreatic-acinar-cells-upon-inflammatory-injury-and-mitogenic-stimulation
#2
Marta Bombardo, Ermanno Malagola, Rong Chen, Alina Rudnicka, Rolf Graf, Sabrina Sonda
BACKGROUND AND PURPOSE: Nonsteroidal anti-inflammatory drugs (NSAIDs) are administered to manage the pain typically found in patients suffering from pancreatitis. NSAIDs also display anti-proliferative activity against cancer cells; however, their effects on normal, untransformed cells are poorly understood. Here, we evaluated whether NSAIDs inhibit the proliferation of pancreatic acinar cells during the development of acute pancreatitis. EXPERIMENTAL APPROACH: The NSAIDs ibuprofen and diclofenac were administered to C57BL/6 mice after induction of pancreatitis with serial injections of cerulein...
May 19, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28440297/efficacy-and-safety-of-rectal-nonsteroidal-anti-inflammatory-drugs-for-prophylaxis-against-post-ercp-pancreatitis-a-systematic-review-and-meta-analysis
#3
Yi-Chao Hou, Qiang Hu, Jiao Huang, Jing-Yuan Fang, Hua Xiong
Rectal nonsteroidal anti-inflammatory drugs (NSAIDs) are not commonly used clinically for preventing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. To evaluate the efficacy and safety of NSAIDs for post-ERCP prophylaxis, we systematically reviewed sixteen randomized controlled trials (involving 6458 patients) that compared rectal NSAIDs with placebo or no treatment for post-ERCP pancreatitis prophylaxis updated to August 2016. GRADE framework was used to assess the quality of evidence...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28374181/diclofenac-does-not-reduce-the-risk-of-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis-in-low-risk-units
#4
Mia Rainio, Outi Lindström, Marianne Udd, Johanna Louhimo, Leena Kylänpää
BACKGROUND: Nonsteroidal anti-inflammatory drugs have an inhibitory role in pathogenesis of pancreatitis. Guidelines from the European Society of Gastrointestinal Endoscopy recommend routine rectal administration of 100 mg of diclofenac or indomethacin immediately before or after ERCP for all patients without contraindications. AIMS: Our aim was to evaluate the effect of diclofenac in preventing post-ERCP pancreatitis (PEP) in a high-volume, low-PEP-risk ERCP unit...
August 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28167118/indomethacin-and-diclofenac-in-the-prevention-of-post-ercp%C3%A2-pancreatitis-a-systematic-review-and-meta-analysis%C3%A2-of-prospective-controlled-trials
#5
REVIEW
Árpád Patai, Norbert Solymosi, László Mohácsi, Árpád V Patai
BACKGROUND AND AIMS: Diclofenac and indomethacin are the most studied drugs for preventing post-ERCP pancreatitis (PEP). However, there are no prospective, randomized multicenter trials with a sufficient number of patients for correct evaluation of their efficacy. Our aim was to evaluate all prospective trials published in full text that studied the efficacy of diclofenac or indomethacin and were controlled with placebo or non-treatment for the prevention of PEP in adult patients undergoing ERCP...
February 4, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28112441/rectal-nsaids-in-the-prevention-of-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis-in-unselected-patients-systematic-review-and-meta-analysis
#6
REVIEW
Chongrong Shen, Yanqiang Shi, Tianyu Liang, Peizhu Su
BACKGROUND AND AIM: Efficacy of rectal non-steroidal anti-inflammatory drugs (NSAIDs) for post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) prophylaxis in unselected patients remained controversial. The aim of the present study was to evaluate the efficacy of rectal NSAIDs in the prevention of PEP in unselected patients. METHODS: An electronic literature search in the Cochrane Library, Embase, and PubMed was carried out for randomized controlled trials comparing rectal indomethacin or diclofenac with placebo in the prevention of PEP in unselected patients...
May 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/27849643/comparison-of-rectal-indomethacin-diclofenac-and-naproxen-for-the-prevention-of-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis
#7
RANDOMIZED CONTROLLED TRIAL
Amir H Mohammad Alizadeh, Mohammad Abbasinazari, Behzad Hatami, Saeed Abdi, Forozan Ahmadpour, Shideh Dabir, Aida Nematollahi, Samira Fatehi, Mohammad A Pourhoseingholi
BACKGROUND AND AIM: NSAIDs are commonly utilized for the prevention of post endoscopic retrograde cholangiopancreatography pancreatitis (PEP). However, not much is known about the most effective drug in preventing this complication. This study aims to clarify which drug (indomethacin, diclofenac, or naproxen) is most effective for the prevention of post endoscopic retrograde cholangiopancreatography (ERCP). MATERIALS AND METHODS: In a double-blind, randomized study, patients received a single rectal dose of one of the three drugs 30 min before undergoing ERCP: diclofenac (100 mg), indomethacin (100 mg), or naproxen (500 mg)...
March 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27815741/erratum-to-diclofenac-sodium-versus-ceftazidime-for-preventing-pancreatitis-after-endoscopic-retrograde-cholangiopancreatography-a-prospective-randomized-controlled-trial
#8
Goran Hauser, Ivana Blažević, Nermin Salkić, Goran Poropat, Vanja Giljača, Zlatko Bulić, Davor Štimac
No abstract text is available yet for this article.
November 4, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27785324/role-of-rectal-diclofenac-suppository-for-prevention-and-its-impact-on-severity-of-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis-in-high-risk-patients
#9
Sandeep Patil, Vikas Pandey, Nilesh Pandav, Meghraj Ingle, Aniruddha Phadke, Prabha Sawant
BACKGROUND: The aim was to study the role of rectal diclofenac in prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis and its impact on severity of post-ERCP pancreatitis. METHODS: We conducted a single-center, prospective, open-labeled, randomized trial for evaluating the use of rectal diclofenac in prevention of post-ERCP pancreatitis in high-risk patients. We assessed 526 patients coming for ERCP for different indications. Four hundred patients were eligible for the study...
June 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/27777436/a-multicenter-prospective-randomized-controlled-trial-evaluating-the-efficacy-of-rectal-diclofenac-and-sublingual-nitroglycerin-as-a-combined-prophylactic-treatment-for-post-ercp-pancreatitis
#10
RANDOMIZED CONTROLLED TRIAL
Takeshi Tomoda, Hironari Kato, Sho Mizukawa, Shinichiro Muro, Yutaka Akimoto, Daisuke Uchida, Kazuyuki Matsumoto, Naoki Yamamoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hiroyuki Okada
Acute pancreatitis is the major complication of endoscopic retrograde cholangiopancreatography (ERCP). A preliminary research suggested that the administration of nonsteroidal anti-inflammatory drugs (NSAIDs) with nitroglycerin might reduce the incidence of post-ERCP pancreatitis (PEP) more effectively than NSAIDs alone. We conduct a two-arm, multicenter, prospective, randomized, superiority trial to evaluate the additional effect of nitroglycerin for prevention of PEP. A total of 900 patients randomly receive 50 mg diclofenac suppository either alone or with 5 mg isosorbide dinitrate sublingual tablet...
2016: Acta Medica Okayama
https://www.readbyqxmd.com/read/27747282/intravenous-injection-of-low-dose-flurbiprofen-axetil-for-preventing-post-ercp-pancreatitis-in-high-risk-patients-an-interim-analysis-of-the-trial
#11
Yuji Fujita, Sho Hasegawa, Yuri Kato, Ken Ishii, Akito Iwasaki, Takamitsu Sato, Yusuke Sekino, Kunihiro Hosono, Atsushi Nakajima, Kensuke Kubota
Background and study aims: Several meta-analyses and randomized control trials have demonstrated the efficacy of rectal nonsteroidal anti-inflammatory drugs for preventing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). Diclofenac or indomethacin was administered at a dose of 100 mg in those studies, which may be too high for Asian population. In addition, rectal administration can be considered complicated. Patients and methods: This study was a prospective, randomized, placebo-controlled trial...
October 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27686941/carboxymethyl-starch-excipients-for-drug-chronodelivery
#12
Pompilia Ispas-Szabo, Patrick De Koninck, Carmen Calinescu, Mircea Alexandru Mateescu
Carboxymethyl starch (CMS) is a pH-responsive excipient exhibiting also interesting properties for applications in delayed drug delivery systems. This work was aimed to investigate the release properties of monolithic and dry-coated tablets based on ionic sodium CMS and on protonated CMS, formulated with three model tracers: acetaminophen, acetylsalicylic acid (ASA), and sodium diclofenac. The sodium or protonated CMS were obtained from the same CMS synthesis by controlling the final pH of reaction media. The two forms of CMS were confirmed by the Fourier transform infrared spectroscopy...
September 29, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27651353/prophylaxis-of-pancreatitis-with-intravenous-ketoprofen-in-a-consecutive-population-of-ercp-patients-a-randomized-double-blind-placebo-controlled-trial
#13
Fernanda de Quadros Onófrio, Julio Carlos Pereira Lima, Guilherme Watte, Romnei Lenon Lehmen, Daniela Oba, Gabriela Camargo, Carlos Eduardo Oliveira Dos Santos
Background Acute pancreatitis is the most common complication after ERCP, occurring in about 4 % of the procedures. Only the placement of pancreatic duct prosthesis and the use of nonsteroidal anti-inflammatory drugs (NSAIDs) have shown benefit in the prevention of post-ERCP pancreatitis (PEP). Although the benefit of rectal administration of indomethacin or diclofenac is recommended by some studies and society guidelines especially in a selected group of high-risk patients, there is so far, no standardization of time or route of NSAID administration...
September 20, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27580214/endoscopic-and-pharmacological-treatment-for-prophylaxis-against-postendoscopic-retrograde-cholangiopancreatography-pancreatitis-a-meta-analysis-and-systematic-review
#14
REVIEW
Salvatore F Vadalà di Prampero, Giacomo Faleschini, Nikola Panic, Milutin Bulajic
BACKGROUND AND AIM: Postendoscopic retrograde cholangiopancreatography (post-ERCP) pancreatitis (PEP) is the most common complication following ERCP. We carried out a systematic review and meta-analysis of the global literature on PEP prevention to provide clinical guidance and a framework for future research in this important field. METHODS: PubMed, Embase, Science Citation Index, Ovid, and the Cochrane Controlled Trials Register were searched by two independent reviewers to identify full-length, prospective, randomized controlled trials (RCTs) published up until March 2016 investigating the use of pancreatic duct stents and pharmacological agents to prevent PEP...
December 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27556283/comparative-study-of-strategies-for-preventing-post-ercp-pancreatitis-after-early-precut-sphincterotomy-for-biliary-access
#15
COMPARATIVE STUDY
Tiing Leong Ang, Andrew Boon Eu Kwek, Mingjun Song, James Weiquan Li, Prem Harichander Thurairajah
OBJECTIVE: Needle knife precut sphincterotomy (PS) during endoscopic retrograde cholangiopancreatography (ERCP) has been associated with a high risk of post-ERCP pancreatitis (PEP). This study aimed to examine the effect of no prophylaxis, somatostatin, rectal diclofenac and pancreatic duct (PD) stenting in reducing rates of PEP in patients who underwent early PS. METHODS: This was a retrospective comparative study and the study period was from January 2006 to December 2015...
October 2016: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27513404/rectal-or-intramuscular-diclofenac-reduces-the-incidence-of-pancreatitis-afterendoscopic-retrograde-cholangiopancreatography
#16
Ramazan Uçar, Murat Biyik, Esma Uçar, İlker Polat, Sami Çifçi, Hüseyin Ataseven, Ali Demir
BACKGROUND/AIM: Acute pancreatitis is the most common adverse event of endoscopic retrograde cholangiopancreatography (ERCP). We aimed to evaluate the efficacy of intramuscular diclofenac sodium for prophylaxis of post-ERCP pancreatitis (PEP) in comparison to the rectal form. MATERIALS AND METHODS: One hundred and fifty consecutive patients who underwent ERCP were enrolled in this single-center, prospective, randomized controlled study. Patients were randomized into three groups...
June 23, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27447477/no-benefit-of-oral-diclofenac-on-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis
#17
RANDOMIZED CONTROLLED TRIAL
Hirotoshi Ishiwatari, Takahiro Urata, Ichiro Yasuda, Shimpei Matsusaki, Hiroyuki Hisai, Hiroshi Kawakami, Michihiro Ono, Takuji Iwashita, Shinpei Doi, Kazumichi Kawakubo, Tsuyoshi Hayashi, Tomoko Sonoda, Naoya Sakamoto, Junji Kato
BACKGROUND: Pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP) is a serious complication. Rectal diclofenac (100 mg) has been shown to reduce the incidence of pancreatitis; however, this dosage form is unavailable in several countries. AIMS: We aimed to investigate the preventive effect of oral diclofenac on pancreatitis after ERCP in a multicenter, randomized, prospective, placebo-controlled, double-blind trial. METHODS: Patients undergoing a first ERCP in seven high-volume centers between July 2012 and August 2014 were considered eligible...
November 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27317032/diclofenac-sodium-versus-ceftazidime-for-preventing-pancreatitis-after-endoscopic-retrograde-cholangiopancreatography-a-prospective-randomized-controlled-trial
#18
Goran Hauser, Ivana Blažević, Nermin Salkić, Goran Poropat, Vanja Giljača, Zlatko Bulić, Davor Štimac
BACKGROUND AND AIMS: We aimed to compare the efficacy of prophylactic, parenterally administered ceftazidime and rectally applied diclofenac sodium for the prophylaxis of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). METHODS: We prospectively enrolled patients who underwent ERCP. In a double-blind, randomized, controlled trial, patients received a suppository containing diclofenac sodium rectally (100 mg) and placebo intravenously (group A) or ceftazidime intravenously (1 g) and placebo rectally (group B) immediately before the procedure...
February 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/27160512/effect-of-body-weight-on-fixed-dose-of-diclofenac-for-the-prevention-of-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis
#19
Bonna Leerhøy, Andreas Nordholm-Carstensen, Srdan Novovic, Mark Berner Hansen, Lars Nannestad Jørgensen
OBJECTIVE: The aim of this study was to assess the influence of patient body weight on the clinical effect of 100 mg diclofenac administered as a single dose for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP). MATERIALS AND METHODS: All patients subjected to endoscopic retrograde cholangiopancreatography (ERCP) from 2009 to 2014 were evaluated for inclusion. In total, 772 patients were included of whom 378 (49%) received diclofenac prophylaxis...
August 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/26990509/early-precut-sphincterotomy-for-difficult-biliary-access-to-reduce-post-ercp-pancreatitis-a-randomized-trial
#20
RANDOMIZED CONTROLLED TRIAL
Alberto Mariani, Milena Di Leo, Nicola Giardullo, Antonella Giussani, Mario Marini, Federico Buffoli, Livio Cipolletta, Franco Radaelli, Paolo Ravelli, Giovanni Lombardi, Vittorio D'Onofrio, Raffaele Macchiarelli, Elena Iiritano, Marco Le Grazie, Giuseppe Pantaleo, Pier Alberto Testoni
BACKGROUND AND STUDY AIM: Precut sphincterotomy is a technique usually employed for difficult biliary cannulation during endoscopic retrograde cholangiopancreatography (ERCP) for the treatment of bile duct disease. It is a validated risk factor for post-ERCP pancreatitis (PEP), but it is not clear whether the risk is related to the technique itself or to the repeated biliary cannulation attempts preceding it. The primary aim of the study was to assess the incidence of PEP in early precut compared with the standard technique in patients with difficult biliary cannulation...
June 2016: Endoscopy
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