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https://www.readbyqxmd.com/read/28222405/thyroid-hormones-a-potential-ally-to-ldl-cholesterol-lowering-agents
#1
REVIEW
Leonidas N Duntas, Gabriela Brenta
L-thyroxine (LT4) treatment of hypothyroidism, particularly in patients with thyroid- stimulating hormone (TSH) >10mU/L, results in improved lipid profile, as LT4 stimulates low-density lipoprotein cholesterol (LDL-C) degradation and the conversion of cholesterol in bile acids by inducing LDL-receptor and 7 alpha hydroxylase expression, respectively. Statins decrease total cholesterol (TC) and LDL-C mainly by suppressing 3-hydroxy-3-methylglutaryl coenzyme A activity. Therefore, the addition of statins to LT4 treatment, following the reversal of hypothyroidism, acts synergistically and forms a powerful treatment modality in patients with this condition whose serum lipids have not achieved the target...
October 2016: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28219642/synergy-of-raddeanin-a-and-cisplatin-induced-therapeutic-effect-enhancement-in-human-hepatocellular-carcinoma
#2
Li Jian-Nan, Yu Ye, Zhang Yan-Fei, Li Zhi-Meng, Cai Guang-Zhi, Gong Ji-Yu
Cisplatin is a main compound for human hepatocellular carcinoma (HCC) chemotherapies, but it has certain cytotoxicity during applications. To release that, combining with other drugs are being as a regular plan in clinic. In our present study, we are focusing on one of active monomers extracted from Anemone Raddeana Regel, Raddeanin A (RA), which is on behalf of the same character like cisplatin in the tumor remedies. In order to investigate whether combination usage of RA and cisplatin can be priority to the later drug's effect development and its toxicity reduction in HCC, both of two drugs were treated 24 h or 48 h in QGY-7703 cells for estimating their abilities in tumor cell proliferation inhibition...
February 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28212645/retrospective-analysis-of-antiretroviral-therapy-uptake-and-retention-of-male-clients-receiving-methadone-maintenance-therapy-in-two-provinces-in-vietnam-potential-synergy-of-the-two-therapies
#3
Linh Thi Thuy Pham, Akiko Kitamura, Hoa Mai Do, Kim Anh Lai, Nhan Tuan Le, Van Thi Thuy Nguyen, Masaya Kato
BACKGROUND: Vietnam has a concentrated HIV epidemic with injection drug use being the dominant mode of HIV transmission. Vietnam has rapidly expanded antiretroviral therapy (ART) and methadone maintenance therapy (MMT). This study aims to analyze ART uptake and retention among male clients receiving MMT in Vietnam in the early phase of the MMT program. METHODS: The male clients (age ≥18) who were newly enrolled in care or started ART at two HIV clinics in Hanoi (2009 to 2011) and three HIV clinics in Can Tho (2010 to 2012) were included for the analysis...
February 17, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28197140/molecular-characteristics-of-carbapenem-resistant-enterobacter-cloacae-in-ningxia-province-china
#4
Zhiyun Shi, Huizheng Zhao, Gang Li, Wei Jia
The emergence of carbapenem-resistant Enterobacteriaceae (CRE) has become a major public health concern worldwide and a new challenge in the treatment of infectious diseases. The molecular characteristics of Enterobacter cloacae in Ningxia China are unknown. In this study, we reported 10 carbapenem-resistant E. cloacae isolates from the General Hospital of Ningxia Medical University, the largest university hospital in Ningxia between January 2012 and December 2013. Bacteria isolates were identified by Vitek2 compact and the identity of non-duplicate E...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28196957/a-novel-small-molecule-inhibitor-of-the-mycobacterium-tuberculosis-demethylmenaquinone-methyltransferase-meng-is-bactericidal-to-both-growing-and-nutritionally-deprived-persister-cells
#5
Paridhi Sukheja, Pradeep Kumar, Nisha Mittal, Shao-Gang Li, Eric Singleton, Riccardo Russo, Alexander L Perryman, Riju Shrestha, Divya Awasthi, Seema Husain, Patricia Soteropoulos, Roman Brukh, Nancy Connell, Joel S Freundlich, David Alland
Active tuberculosis (TB) and latent Mycobacterium tuberculosis infection both require lengthy treatments to achieve durable cures. This problem has partly been attributable to the existence of nonreplicating M. tuberculosis "persisters" that are difficult to kill using conventional anti-TB treatments. Compounds that target the respiratory pathway have the potential to kill both replicating and persistent M. tuberculosis and shorten TB treatment, as this pathway is essential in both metabolic states. We developed a novel respiratory pathway-specific whole-cell screen to identify new respiration inhibitors...
February 14, 2017: MBio
https://www.readbyqxmd.com/read/28195491/prodrug-like-pegylated-protein-toxin-trichosanthin-for-reversal-of-chemoresistance
#6
Yingzhi Chen, Meng Zhang, Hongyue Jin, Yisi Tang, Aihua Wu, Qin Xu, Yongzhuo Huang
Multidrug resistance (MDR) is a main obstacle in cancer chemotherapy. The MDR mechanisms involve P-glycoprotein (P-gp) overexpression, abnormality of apoptosis-related protein, and altered expression of drug-targeting proteins. Therapeutic proteins are emerging as candidates for overcoming cancer MDR because of not only their large molecular size that potentially circumvents the P-gp-mediated drug efflux but also their distinctive bioactivity distinguished from small-molecular drugs. Herein we report trichosanthin, a plant protein toxin, possesses synergistic effect with paclitaxel (PTX) in the PTX-resistance A549/T nonsmall cell lung cancer (NSCLC) cells, by reversing PTX-caused caspase 9 phosphorylation and inducing caspase 3-dependent apoptosis...
February 14, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28189106/application-of-sequential-factorial-design-and-orthogonal-array-composite-design-oacd-to-study-combination-of-5-prostate-cancer-drugs
#7
Xiaolong Jia, Yiyang Li, Alok Sharma, Yulong Li, Guohai Xie, Guoyao Wang, Junhui Jiang, Yue Cheng, Xianting Ding
Prostate cancer is one of the most common cancers among men in the United States. It is also a major leading cause of cancer death among men of all races. In order to treat prostate cancer, drug combinations are often applied. Drug combinations target at different pathways of cells can potentially lead to higher efficacy and lower toxicity due to drug synergy. In this paper, we sequentially applied a two-level design and a follow-up orthogonal array composite design (OACD) to investigate combinations of five anti-cancer drugs, namely, doxorubicin, docetaxel, paclitaxel, cis-dichlorodiamine platinum and dihydroartemisinin...
February 4, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28188830/in-vitro-activity-of-clarithromycin-in-combination-with-other-antimicrobial-agents-against-mycobacterium-abscessus-and-mycobacterium-massiliense
#8
Zhijian Zhang, Jie Lu, Min Liu, Yufeng Wang, Yanlin Zhao, Yu Pang
Macrolides, especially clarithromycin (CLA), remain the cornerstone of therapy for Mycobacterium abscessus complex infections. The purpose of this study was to gather results from in vitro drug susceptibility testing of M. abscessus and Mycobacterium massiliense for the combination of CLA with various other agents, including linezolid (LZD), moxifloxacin (MOX), amikacin (AMK) and tigecycline (TGC). A total of 40 M. abscessus complex isolates were studied, comprising 20 M. abscessus and 20 M. massiliense strains...
February 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28185846/corticoids-synergize-with-il-1-in-the-induction-of-lcn2
#9
J Conde, V Lazzaro, M Scotece, V Abella, R Villar, V López, M Á Gonzalez-Gay, J Pino, R Gómez, A Mera, O Gualillo
OBJECTIVE: Lipocalin-2 (LCN2) is an adipokine that was first identified in neutrophil granules. In the last years it was recognized as a factor that could impair chondrocyte phenotype, cartilage homeostasis as well as growth plate development. Both pro-inflammatory cytokines and glucocorticoids (GCs) modulate LCN2 expression. Actually, GCs were found to be LCN2 inducers, suggesting that part of the negative actions exerted by these anti-inflammatory drugs at cartilage level could be mediated by this adipokine...
February 6, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28185779/corrigendum-to-comparison-of-the-clinical-efficacy-between-tigecycline-plus-extended-infusion-imipenem-and-sulbactam-plus-imipenem-against-ventilator-associated-pneumonia-with-pneumonic-extensively-drug-resistant-acinetobacter-baumannii-bacteremia-and-correlation
#10
https://www.readbyqxmd.com/read/28183605/obtaining-the-palygorskite-chitosan-composite-for-modified-release-of-5-aminosalicylic-acid
#11
Ana Cristina Sousa Gramoza Vilarinho Santana, José Lamartine Soares Sobrinho, Edson Cavalcanti da Silva Filho, Livio Cesar Cunha Nunes
This study's aim was to obtain composites from palygorskite (PLG) and chitosan (CS) in order to modify 5-aminosalicylic (5-ASA) release. Initially, the PLG:CS composite was obtained using glutaraldehyde (GLA) as a reticular agent. Then, PLG, CS and PLG:CS were characterized by means of analytical techniques such as CHN elemental analysis, surface area analysis, XRD, FTIR, DSC and TG, SEM, adsorption tests and release profiles. Based on analytical data, the formation of the PLG:CS composite which showed the presence about 19% of CS, decrease in specific surface area, morphological analysis modified, visible change of crystallinity, of FTIR and thermal analysis...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28176481/synergistic-activity-profile-of-an-antimicrobial-peptide-against-multidrug-resistant-and-extensively-drug-resistant-strains-of-gram-negative-bacterial-pathogens
#12
Simona Pollini, Jlenia Brunetti, Samanta Sennati, Gian Maria Rossolini, Luisa Bracci, Alessandro Pini, Chiara Falciani
Infection sustained by multidrug-resistant and extensively drug-resistant bacterial pathogens is often untreatable with the standard of care antibiotics, and the combination of anti-infective compounds often represents the only therapeutic strategy to face this major clinical treat. SET-M33 is a novel antimicrobial peptide (AMP) that has demonstrated in vitro and in vivo antimicrobial activity against Gram-negative bacteria and has shown interesting features in preclinical evaluations. Particularly, it showed efficacy against a number of multidrug-resistant and extensively drug-resistant clinical strains of Gram-negative pathogens, in in vitro and in vivo assessments...
February 8, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28168390/supramolecular-chitosan-micro-platelets-synergistically-enhance-anti-candida-albicans-activity-of-amphotericin-b-using-an-immunocompetent-murine-model
#13
Tiphany Grisin, Christian Bories, Martina Bombardi, Philippe M Loiseau, Valérie Rouffiac, Audrey Solgadi, Jean-Maurice Mallet, Gilles Ponchel, Kawthar Bouchemal
PURPOSE: The aim of this work is to design new chitosan conjugates able to self-organize in aqueous solution in the form of micrometer-size platelets. When mixed with amphotericin B deoxycholate (AmB-DOC), micro-platelets act as a drug booster allowing further improvement in AmB-DOC anti-Candida albicans activity. METHODS: Micro-platelets were obtained by mixing oleoyl chitosan and α-cyclodextrin in water. The formulation is specifically-engineered for mucosal application by dispersing chitosan micro-platelets into thermosensitive pluronic(®) F127 20 wt% hydrogel...
February 6, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28167347/synergy-against-extensively-drug-resistant-acinetobacter-baumannii-in-vitro-by-two-old-antibiotics-colistin-and-chloramphenicol
#14
Wen-Juan Wei, Hai-Fei Yang
Combination antimicrobial therapy is an important option in the fight against Gram-negative 'superbugs'. This study systematically investigated the synergistic effect of colistin (CST) and chloramphenicol (CHL) in combination against extensively drug-resistant Acinetobacter baumannii (XDR-AB). The microtitre plate chequerboard assay was used to test synergy against 50 XDR-AB clinical strains. Then, three XDR-AB clinical isolates and the type strain A. baumannii ATCC 19606 were chosen for further synergy studies using time-kill assay, mutant prevention concentration (MPC) assay and real-time population analysis profile (PAP) assay...
February 3, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28165501/therapeutic-effects-of-euphorbia-pekinensis-and-glycyrrhiza-glabra-on-hepatocellular-carcinoma-ascites-partially-via-regulating-the-frk-arhgdib-inpp5d-avpr2-aqp4-signal-axis
#15
Yanqiong Zhang, Chen Yan, Yuting Li, Xia Mao, Weiwei Tao, Yuping Tang, Ya Lin, Qiuyan Guo, Jingao Duan, Na Lin
To clarify unknown rationalities of herbaceous compatibility of Euphorbia Pekinensis (DJ) and Glycyrrhiza glabra (GC) acting on hepatocellular carcinoma (HCC) ascites, peritoneum transcriptomics profiling of 15 subjects, including normal control (Con), HCC ascites mouse model (Mod), DJ-alone, DJ/GC-synergy and DJ/GC-antagonism treatment groups were performed on OneArray platform, followed by differentially expressed genes (DEGs) screening. DEGs between Mod and Con groups were considered as HCC ascites-related genes, and those among different drug treatment and Mod groups were identified as DJ/GC-combination-related genes...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28165460/programmable-transcriptional-repression-in-mycobacteria-using-an-orthogonal-crispr-interference-platform
#16
Jeremy M Rock, Forrest F Hopkins, Alejandro Chavez, Marieme Diallo, Michael R Chase, Elias R Gerrick, Justin R Pritchard, George M Church, Eric J Rubin, Christopher M Sassetti, Dirk Schnappinger, Sarah M Fortune
The development of new drug regimens that allow rapid, sterilizing treatment of tuberculosis has been limited by the complexity and time required for genetic manipulations in Mycobacterium tuberculosis. CRISPR interference (CRISPRi) promises to be a robust, easily engineered and scalable platform for regulated gene silencing. However, in M. tuberculosis, the existing Streptococcus pyogenes Cas9-based CRISPRi system is of limited utility because of relatively poor knockdown efficiency and proteotoxicity. To address these limitations, we screened eleven diverse Cas9 orthologues and identified four that are broadly functional for targeted gene knockdown in mycobacteria...
February 6, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28163223/influence-of-peptide-dendrimers-and-sonophoresis-on-the-transdermal-delivery-of-ketoprofen
#17
Jyothsna Manikkath, Aswathi R Hegde, Guruprasad Kalthur, Harendra S Parekh, Srinivas Mutalik
The aim of this study was to determine the individual and combined effects of peptide dendrimers and low frequency ultrasound on the transdermal permeation of ketoprofen. Arginine terminated peptide dendrimers of varying charges (4(+), 8(+) and 16(+), named as A4. A8 and A16 respectively) were synthesized and characterized. Ketoprofen was subjected to passive, peptide dendrimer-assisted and sonophoretic permeation studies (with and without dendrimer application) across Swiss albino mouse skin, both in vitro and in vivo...
February 2, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28153578/improving-drug-like-properties-of-insulin-and-glp-1-via-molecule-design-and-formulation-and-improving-diabetes-management-with-device-drug-delivery
#18
REVIEW
Sergei Pechenov, Himanshu Bhattacharjee, Daniel Yin, Sachin Mittal, Anand Subramony
There is an increased incidence of diabetes worldwide. The discovery of insulin revolutionized the management of diabetes, the revelation of glucagon-like peptide -1 (GLP-1) and introduction of GLP-1 mimetics to clinical practice was another breakthrough. Continued translational research resulted in better understanding of diabetes, which, in combination with cutting-edge biology, chemistry, and pharmaceutical tools, have allowed for the development of safer, more effective and convenient insulins and GLP-1s...
January 30, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28149293/the-antifungal-activity-of-lactoferrin-and-its-derived-peptides-mechanisms-of-action-and-synergy-with-drugs-against-fungal-pathogens
#19
REVIEW
Kenya E Fernandes, Dee A Carter
Lactoferrin is a multifunctional iron-binding glycoprotein belonging to the transferrin family. It is found abundantly in milk and is present as a major protein in human exocrine secretions where it plays a role in the innate immune response. Various antifungal functions of lactoferrin have been reported including a wide spectrum of activity across yeasts and molds and synergy with other antifungal drugs in combination therapy, and various modes of action have been proposed. Bioactive peptides derived from lactoferrin can also exhibit strong antifungal activity, with some surpassing the potency of the whole protein...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28144154/occurrence-of-extended-spectrum-and-ampc-%C3%AE-lactamases-in-multiple-drug-resistant-salmonella-isolates-from-clinical-samples-in-lagos-nigeria
#20
K O Akinyemi, Bamidele Abiodun Iwalokun, Akeeb O Bola Oyefolu, C O Fakorede
PURPOSE: Salmonella spp. are important foodborne pathogens exhibiting increasing resistance to antimicrobial drugs. Resistance to broad-spectrum β-lactams, mediated by extended-spectrum β-lactamase (ESBL) and AmpC β-lactamase enzymes is fast spreading and has had negative impacts on the clinical outcomes, particularly on third-generation cephalosporins. This study investigated the carriage of AmpC gene among multidrug-resistant Salmonella spp. from Lagos, Nigeria. METHODS: Forty Salmonella spp...
2017: Infection and Drug Resistance
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