Kate Luisi, Kaitlyn M Morabito, Katherine E Burgomaster, Mayuri Sharma, Wing-Pui Kong, Bryant M Foreman, Sonal Patel, Brian Fisher, Maya A Aleshnick, Jason Laliberte, Madison Wallace, Tracy J Ruckwardt, David N Gordon, Christine Linton, Nicole Ruggiero, Jessica L Cohen, Russell Johnson, Kunal Aggarwal, Sung-Youl Ko, Eun Sung Yang, Rebecca S Pelc, Kimberly A Dowd, Derek O'Hagan, Jeffrey Ulmer, Sally Mossman, Anna Sambor, Edith Lepine, John R Mascola, Theodore C Pierson, Barney S Graham, Dong Yu
Zika virus (ZIKV) is the cause of a pandemic associated with microcephaly in newborns and Guillain-Barre syndrome in adults. Currently, there are no available treatments or vaccines for ZIKV, and the development of a safe and effective vaccine is a high priority for many global health organizations. We describe the development of ZIKV vaccine candidates using the self-amplifying messenger RNA (SAM) platform technology delivered by cationic nanoemulsion (CNE) that allows bedside mixing and is particularly useful for rapid responses to pandemic outbreaks...
August 2020: Science Advances