keyword
MENU ▼
Read by QxMD icon Read
search

Guillain–Barré zika

keyword
https://www.readbyqxmd.com/read/28074023/emergence-of-epidemic-zika-virus-transmission-and-congenital-zika-syndrome-are-recently-evolved-traits-to-blame
#1
Scott C Weaver
The mechanisms responsible for the dramatic emergence of Zika virus (ZIKV), accompanied by congenital Zika syndrome and Guillain-Barré syndrome (GBS), remain unclear. However, two hypotheses are prominent: (i) evolution for enhanced urban transmission via adaptation to mosquito vectors, or for enhanced human infection to increase amplification, or (ii) the stochastic introduction of ZIKV into large, naive human populations in regions with abundant Aedes aegypti populations, leading to enough rare, severe infection outcomes for their first recognition...
January 10, 2017: MBio
https://www.readbyqxmd.com/read/28069378/role-of-n-glycosylation-on-zika-virus-e-protein-secretion-viral-assembly-and-infectivity
#2
M Mossenta, S Marchese, M Poggianella, J L Slon Campos, O R Burrone
Zika virus has rapidly spread reaching a global distribution pattern similar to that of dengue virus, and has been associated with serious neurological and developmental pathologies, like congenital malformation during pregnancy and Guillain-Barré syndrome. Sequence analysis of different clinical and laboratory isolates has shown the existence of mutants with loss of the conserved N-glycosylation motif on domain I of protein E that is common to all flaviviruses. We found that loss of E N-linked glycosylation leads to compromised expression and secretion of E ectodomain from mammalian cells...
January 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28062188/a-comprehensive-analysis-and-immunobiology-of-autoimmune-neurological-syndromes-during-the-zika-virus-outbreak-in-c%C3%A3%C2%BAcuta-colombia
#3
Juan-Manuel Anaya, Yhojan Rodríguez, Diana M Monsalve, Daniel Vega, Ernesto Ojeda, Diana González-Bravo, Mónica Rodríguez-Jiménez, Carlos A Pinto-Díaz, Pablo Chaparro, María L Gunturiz, Aftab A Ansari, M Eric Gershwin, Nicolás Molano-González, Carolina Ramírez-Santana, Yeny Acosta-Ampudia
We have focused on the epidemiology and immunobiology of Zika virus (ZIKV) infection and factors associated with the development of Guillain-Barré syndrome (GBS) and other neurological syndromes in Cúcuta, the capital of North Santander department, Colombia. Data of patients with ZIKV disease reported to the national population-based surveillance system were used to calculate the basic reproduction number (R0) and the attack rates (ARs) as well as to develop epidemiological maps. Patients with neurological syndromes were contacted and their diagnoses were confirmed...
January 3, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28058206/zika-virus-disease-for-neurologists
#4
REVIEW
Daniel E Smith, J David Beckham, Kenneth L Tyler, Daniel M Pastula
PURPOSE OF REVIEW: Zika virus (ZIKV) was not initially thought to be an important cause of neurologic disease, but with the recent epidemic in the Western Hemisphere, there is a growing body of evidence for possible neurologic complications. This review discusses these in addition to what is known about modes of transmission, testing for the virus, as well as future directions. RECENT FINDINGS: ZIKV disease has been associated with microcephaly and congenital eye disease in infants, as well as with Guillain-Barré syndrome, uveitis, myelitis, and meningoencephalitis in adults...
December 2016: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/28053366/acute-flaccid-paralysis-incidence-and-zika-virus-surveillance-pacific-islands
#5
Adam T Craig, Michelle T Butler, Roberta Pastore, Beverley J Paterson, David N Durrheim
PROBLEM: The emergence of Zika virus has challenged outbreak surveillance systems in many at-risk, low-resource countries. As the virus has been linked with Guillain-Barré syndrome, routine data on the incidence of acute flaccid paralysis (AFP) may provide a useful early warning system for the emergence of Zika virus. APPROACH: We documented all Zika virus outbreaks and cases in 21 Pacific Islands and territories for the years 2007 to 2015. We extracted data from the Global Polio Eradication Initiative database on the reported and expected annual incidence of AFP in children younger than 15 years...
January 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/28049830/characterization-of-cytopathic-factors-through-genome-wide-analysis-of-the-zika-viral-proteins-in-fission-yeast
#6
Ge Li, Melissa Poulsen, Csaba Fenyvuesvolgyi, Yoko Yashiroda, Minoru Yoshida, J Marc Simard, Robert C Gallo, Richard Y Zhao
The Zika virus (ZIKV) causes microcephaly and the Guillain-Barré syndrome. Little is known about how ZIKV causes these conditions or which ZIKV viral protein(s) is responsible for the associated ZIKV-induced cytopathic effects, including cell hypertrophy, growth restriction, cell-cycle dysregulation, and cell death. We used fission yeast for the rapid, global functional analysis of the ZIKV genome. All 14 proteins or small peptides were produced under an inducible promoter, and we measured the intracellular localization and the specific effects on ZIKV-associated cytopathic activities of each protein...
January 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28045901/zika-virus-infection-as-a-cause-of-congenital-brain-abnormalities-and-guillain-barr%C3%A3-syndrome-systematic-review
#7
Fabienne Krauer, Maurane Riesen, Ludovic Reveiz, Olufemi T Oladapo, Ruth Martínez-Vega, Teegwendé V Porgo, Anina Haefliger, Nathalie J Broutet, Nicola Low
BACKGROUND: The World Health Organization (WHO) stated in March 2016 that there was scientific consensus that the mosquito-borne Zika virus was a cause of the neurological disorder Guillain-Barré syndrome (GBS) and of microcephaly and other congenital brain abnormalities based on rapid evidence assessments. Decisions about causality require systematic assessment to guide public health actions. The objectives of this study were to update and reassess the evidence for causality through a rapid and systematic review about links between Zika virus infection and (a) congenital brain abnormalities, including microcephaly, in the foetuses and offspring of pregnant women and (b) GBS in any population, and to describe the process and outcomes of an expert assessment of the evidence about causality...
January 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28034741/identification-of-novel-small-molecule-inhibitors-against-ns2b-ns3-serine-protease-from-zika-virus
#8
Hyun Lee, Jinhong Ren, Salvatore Nocadello, Amy J Rice, Isabel Ojeda, Samuel Light, George Minasov, Jason Vargas, Dhanapalan Nagarathnam, Wayne F Anderson, Michael E Johnson
Zika flavivirus infection during pregnancy appears to produce higher risk of microcephaly, and also causes multiple neurological problems such as Guillain-Barré syndrome. The Zika virus is now widespread in Central and South America, and is anticipated to become an increasing risk in the southern United States. With continuing global travel and the spread of the mosquito vector, the exposure is expected to accelerate, but there are no currently approved treatments against the Zika virus. The Zika NS2B/NS3 protease is an attractive drug target due to its essential role in viral replication...
December 26, 2016: Antiviral Research
https://www.readbyqxmd.com/read/28032327/emerging-zika-virus-infection-a-rapidly-evolving-situation
#9
Bordi Licia, Avsic-Zupanc Tatjana, Lalle Eleonora, Vairo Francesco, Capobianchi Maria Rosaria, Pedro Fernando da Costa Vasconcelos
Zika virus is a mosquito-borne flavivirus, firstly identified in Uganda and responsible for sporadic human cases in Africa and Asia until recently, when large outbreak occurred in Pacific Ocean and the Americas. Since the main vectors during its spread outside of Africa have been Ae. albopictus and Ae. aegypti mosquitoes, which are widely distributed all over the world, there is urgent need for a coordinated response for prevention and spread of ZIKV epidemics.Despite clinical manifestation of Zika virus infection are usually mild and self limiting, there are reports suggesting, during the recent epidemic, an association of ZIKV infection with severe consequences, including fetal/newborn microcephaly, due to vertical in utero transmission, autoimmune-neurological presentations including cranial nerve dysfunction, and Guillain-Barré Syndrome in adults...
December 29, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28031359/the-zika-virus-methyltransferase-structure-and-functions-for-drug-design-perspectives
#10
Bruno Coutard, Karine Barral, Julie Lichière, Barbara Selisko, Baptiste Martin, Wahiba Aouadi, Miguel Ortiz Lombardia, Françoise Debart, Jean-Jacques Vasseur, Jean Claude Guillemot, Bruno Canard, Etienne Decroly
: The Flavivirus Zika virus (ZIKV) is the causing agent of neurological disorders like microcephaly in newborns or Guillain-Barre syndrome. Its NS5 protein embeds a methyltransferase (MTase) domain involved in the formation of the viral mRNA cap. We investigated the structural and functional properties of the ZIKV MTase. We show that the ZIKV MTase can methylate RNA cap structures at the N7 position of the cap, and at the 2' O position on the ribose of the first nucleotide, yielding a cap-1 structure...
December 28, 2016: Journal of Virology
https://www.readbyqxmd.com/read/28002820/zika-virus-infection-in-the-elderly-possible-relationship-with-guillain-barr%C3%A3-syndrome
#11
Wilson Savino, Carolina V Messias, Daniella A Mendes-da-Cruz, Pamela Passos, Ana Carolina A F Ferreira, Osvaldo J Nascimento
The Zika virus (ZIKV) outbreak in French Polynesia, in 2013, and in Brazil, in 2015, was correlated with neurological complications, which comprised, among others, congenital microcephaly and Guillain-Barré syndrome (GBS), which includes a group of acute autoimmune neuropathies generally reported after respiratory or gastrointestinal infectious diseases. Despite being relatively rare, the incidence rate of GBS rises with age, which makes GBS more frequent in the elderly, in whom it is also a more severe disease with slower recovery than in younger patients...
December 22, 2016: Gerontology
https://www.readbyqxmd.com/read/27995511/zika-virus-disease-for-the-neurointensivist
#12
Daniel M Pastula, Julia C Durrant, Daniel E Smith, J David Beckham, Kenneth L Tyler
Zika virus (ZIKV) is a mosquito-borne and sexually transmitted flavivirus currently spreading throughout the Pacific and Western Hemisphere. ZIKV infection is often either asymptomatic or causes a self-limiting illness with symptoms such as rash, fever, myalgia, arthralgia, headache, or conjunctivitis. Rarely, ZIKV infection has been associated with conditions such as severe thrombocytopenia, microcephaly and other developmental abnormalities, acute polyneuropathy/Guillain-Barré syndrome, myelitis, meningoencephalitis, transient encephalopathy, provoked seizures, and various ophthalmologic conditions...
December 19, 2016: Neurocritical Care
https://www.readbyqxmd.com/read/27993851/analysis-of-ribonucleotide-5-triphosphate-analogs-as-potential-inhibitors-of-zika-virus-rna-dependent-rna-polymerase-using-non-radioactive-polymerase-assays
#13
Gaofei Lu, Gregory R Bluemling, Paul Collop, Michael Hager, Damien Kuiper, Bharat P Gurale, George R Painter, Abel De La Rosa, Alexander A Kolykhalov
Zika virus (ZIKV) is an emerging human pathogen that is spreading rapidly through the Americas and has been linked to the development of microcephaly and to a dramatically increased number of Guillain-Barre Syndrome cases. Currently, no vaccine or therapeutic options exist for the prevention or treatment of ZIKV infections. In this report, we have expressed, purified and characterized full-length NS5 and the polymerase domain (NS5pol) of ZIKV RNA-dependent RNA polymerase. Using purified NS5, we have developed an in vitro non-radioactive primer extension assay employing a fluorescently labeled primer-template pair...
December 19, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27966802/zika-virus-a-new-threat-to-human-reproduction
#14
REVIEW
David Baud, Didier Musso, Manon Vouga, Marco P Alves, Nicolas Vulliemoz
Zika virus (ZIKV) was first isolated in 1947 in a rhesus monkey from the Zika forest of Uganda. Until 2007, only 14 human cases were reported. The first large human outbreak occurred in 2007 (Yap Island, Federated States of Micronesia, Pacific) followed by French Polynesia in 2013 and Brazil in 2015. The virus is mainly transmitted through Aedes mosquito bites, but sexual and post-transfusion transmissions have been reported. Symptoms include low-grade fever, maculopapular rash, conjunctivitis, myalgia, arthralgia, and asthenia...
December 14, 2016: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/27934884/rapid-affordable-and-portable-medium-throughput-molecular-device-for-zika-virus
#15
Kamfai Chan, Scott C Weaver, Pui-Yan Wong, Sherly Lie, Eryu Wang, Mathilde Guerbois, Siva Praneeth Vayugundla, Season Wong
Zika virus (ZIKV) has gained global attention as an etiologic agent of fetal microcephaly and Guillain-Barré syndrome. Existing immuno-based rapid tests often fail to distinguish between Zika and related flaviviruses that are common in affected regions of Central and South Americas and the Caribbean. The US CDC and qualified state health department laboratories can perform the reverse transcription polymerase chain reaction (RT-PCR) ZIKV test using highly sophisticated instruments with long turnaround times...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27930910/the-neurobiology-of-zika-virus
#16
REVIEW
Hongda Li, Laura Saucedo-Cuevas, Sujan Shresta, Joseph G Gleeson
Zika virus (ZIVK) represents a new threat to global health, with particular relevance to neuroscientists, due to associated newborn and adult neurological disease. Consequences of vertical infection include microcephaly with brain and eye anomalies, and consequences of adult infection include Guillain-Barré syndrome (GBS) and meningoencephalitis. Recent data suggest specific vulnerability of neural progenitors to infection, leading to cell death and brain calcification, reminiscent of other viral syndromes...
December 7, 2016: Neuron
https://www.readbyqxmd.com/read/27929575/zika-virus-and-guillain-barr%C3%A3-syndrome
#17
M A Ellul, C N Soares, T Solomon
No abstract text is available yet for this article.
June 2016: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/27927917/zika-virus-testing-considerations-lessons-learned-from-the-first-eighty-real-time-rt-pcr-positive-cases-diagnosed-in-new-york-state
#18
Kirsten St George, Inderbir S Sohi, Elizabeth M Dufort, Amy B Dean, Jennifer L White, Ronald Limberger, Jamie N Sommer, Stephanie Ostrowski, Susan J Wong, P Bryon Backenson, Daniel Kuhles, Debra Blog, Jill Taylor, Brad Hutton, Howard A Zucker
The performance and interpretation of laboratory tests for Zika virus (ZKV) continue to be evaluated. Serology is cross-reactive, laborious and frequently difficult to interpret and serum was initially solely recommended for molecular diagnosis. ZKV testing was initiated January 2016 in New York State for symptomatic patients, pregnant women, their infants, and patients with Guillain-Barré Syndrome, who traveled to areas with ZKV transmission. Subsequently, eligibility was expanded to pregnant women with sexual partners with similar travel history...
December 7, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27923889/zika-virus-a-serious-global-health-threat
#19
Candice J McNeil, Avinash K Shetty
In February 2016, the World Health Organization declared Zika virus (ZIKV) infection a public health emergency of international concern, given the precipitous spread of the virus across the Americas. Unlike arboviruses such as Chikungunya and Dengue, which have also recently emerged in the western hemisphere, ZIKV was identified in communities where concurrent neurologic conditions such as microcephaly and Guillain-Barre (GB) syndrome were occurring at alarming rates. Thus, investigations to systematically evaluate the link between ZIKV, congenital malformations (including microcephaly) and GB syndrome remain a top priority...
December 5, 2016: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/27919709/evaluation-of-anti-zika-virus-activities-of-broad-spectrum-antivirals-and-nih-clinical-collection-compounds-using-a-cell-based-high-throughput-screen-assay
#20
Robert S Adcock, Yong-Kyu Chu, Jennifer E Golden, Dong-Hoon Chung
Recent studies have clearly underscored the association between Zika virus (ZIKV) and severe neurological diseases such as microcephaly and Guillain-Barre syndrome. Given the historical complacency surrounding this virus, however, no significant antiviral screenings have been performed to specifically target ZIKV. As a result, there is an urgent need for a validated screening method and strategy that is focused on highlighting potential anti-ZIKV inhibitors that can be further advanced via rigorous validation and optimization...
February 2017: Antiviral Research
keyword
keyword
90838
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"