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a20 dream

Chinnaswamy Tiruppathi, Dheeraj Soni, Dong-Mei Wang, Jiaping Xue, Vandana Singh, Prabhakar B Thippegowda, Bopaiah P Cheppudira, Rakesh K Mishra, Auditi Debroy, Zhijian Qian, Kurt Bachmaier, You-Yang Zhao, John W Christman, Stephen M Vogel, Averil Ma, Asrar B Malik
Here we found that the transcription repressor DREAM bound to the promoter of the gene encoding A20 to repress expression of this deubiquitinase that suppresses inflammatory NF-κB signaling. DREAM-deficient mice displayed persistent and unchecked A20 expression in response to endotoxin. DREAM functioned by transcriptionally repressing A20 through binding to downstream regulatory elements (DREs). In contrast, binding of the transcription factor USF1 to the DRE-associated E-box domain in the gene encoding A20 activated its expression in response to inflammatory stimuli...
March 2014: Nature Immunology
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