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Michelle M O'Shaughnessy, Sai Liu, Maria E Montez-Rath, Richard A Lafayette, Wolfgang C Winkelmayer
BACKGROUND: Whether kidney transplantation rates differ by glomerulonephritis (GN) subtype remains largely unknown. METHODS: Using the US Renal Data System, we identified all adult patients with ESRD attributed to 1 of 6 GN subtypes who initiated dialysis in the US (1996-2013). Patients with diabetic nephropathy (DN) and autosomal-dominant polycystic kidney disease (ADPKD) served as "external" non-GN comparators. Using Cox proportional hazards regression, with death considered a competing risk, we estimated hazard ratios [HRs (95% confidence intervals)] for first kidney transplantation, controlling for year, demographics, comorbidities, socioeconomic factors, and Organ Procurement Organization (OPO)...
February 15, 2017: Transplantation
A S Paramesh, N Neidlinger, M Salvatore, A Smith, A Friedman, W Payne, T Taber, C Wright
Since the advent of the Kidney Allocation System (KAS), matched candidates with high (>98%) panel reactive antibody (hPRA) are given priority over local candidates with lower PRA. This often leads to exporting of kidneys. Data for these kidneys is not detailed on routine reports. Twenty two organ procurement organizations prospectively submitted data from 8/2015 - 7/2016, describing allocation practices of kidneys to hPRA patients and outcomes of these kidneys. 520 out of 6924 procured kidneys were exported for hPRA recipients...
February 6, 2017: American Journal of Transplantation
Wenlong Yang, Ang Li, Yuanzhen Suo, Fa-Ke Lu, X Sunney Xie
Stimulated Raman scattering (SRS) microscopy is a label-free chemical imaging technique. Two-color imaging is often necessary to determine the distribution of chemical species in SRS microscopy. Current multi-color SRS imaging methods involve complicated instrumentation or longer data acquisition time or are limited to transmission imaging. In this Letter, we show that by adding a simple fiber amplifier to a 2 ps laser source and optical-parametric-oscillator-based SRS setup, one can achieve simultaneous two-color or frequency modulation SRS microscopy...
February 1, 2017: Optics Letters
Yajun Wang, Wenhai Yang, Zhixiu Li, Yaohui Zheng
Non-classical squeezed states of light at a compatible atomic wavelength have a potential application in quantum information protocols for quantum states delaying or storaging. An optical parametric oscillator (OPO) with periodically poled potassium titanyl phosphate (PPKTP) is the most effective method for generating this squeezed state. However, it is a challege for the nonlinear interaction in PPKTP crystal at the D1 line of rubidium atomic, due to a strong blue-light-induced infrared absorption (BLIIRA)...
February 1, 2017: Scientific Reports
Yannick Saalberg, Henry Bruhns, Marcus Wolff
With 1.6 million deaths per year, lung cancer is one of the leading causes of death worldwide. One reason for this high number is the absence of a preventive medical examination method. Many diagnoses occur in a late cancer stage with a low survival rate. An early detection could significantly decrease the mortality. In recent decades, certain substances in human breath have been linked to certain diseases. Different studies show that it is possible to distinguish between lung cancer patients and a healthy control group by analyzing the volatile organic compounds (VOCs) in their breath...
January 21, 2017: Sensors
Madhukar S Patel, Jahan Mohebali, Mitchell Sally, Tahnee Groat, Parsia A Vagefi, David C Chang, Darren J Malinoski
BACKGROUND: Identification of strategies to improve organ donor use remains imperative. Despite the association between hospital volume and outcomes for many common disease processes, there have been no studies that assess the impact of organ donor hospital volume on organ yield. STUDY DESIGN: A prospective observational study of all deceased organ donors managed by 10 organ procurement organizations across United Network for Organ Sharing regions 4, 5, and 6 was conducted from February 2012 to June 2015...
January 17, 2017: Journal of the American College of Surgeons
Joseph Benton Oliver, Andrea Fleisch Marcus, Mark Paster, Joseph Nespral, Advaith Bongu, George Dikdan, Lloyd Brown, Nikole Neidlinger, Baburao Koneru
BACKGROUND: Prerecovery liver biopsy (PLB) allows histological evaluation of the organ prior to procurement. The opinions and what factors might influence PLB use within Organ Procurement Organizations (OPOs) are unknown. METHODS: A survey instrument was distributed by the Association of OPOs to the clinical directors of all 58 OPOs. Descriptive statistics were calculated. Results were also stratified based on OPO characteristics. RESULTS: 84...
January 9, 2017: Transplantation
Wenlong Tian, Zhaohua Wang, Jiangfeng Zhu, Zhiyi Wei
We report a multi-gigahertz (GHz) repetition-rate femtosecond MgO:PPLN optical parametric oscillator (OPO) harmonically pumped by a 75.6 MHz Kerr-lens mode-locked Yb:KGW laser. By fractionally increasing the OPO cavity length, we obtained OPO operation up to the 493rd harmonic of the pump laser repetition rate, corresponding to a repetition rate as high as 37.3 GHz. Using a 1.5% output coupler, we are able to extract signal pulses with up to 260 mW average power at the 102nd harmonic (7.7 GHz) and 90 mW at the 493rd harmonic (37...
December 26, 2016: Optics Express
Haizhe Zhong, Fen Qin, Jianlong Yang, Lifu Zhang, Changwen Xu, Ying Li, Dianyuan Fan
Restricted to temporal separation during the coupled-waves interaction, aperiodically quasi-phase-matching (QPM) nonlinear crystals are primarily implemented for prechirped pulses, showing limited applications in ultrafast temporal scale. Under the proposed time-synchronization framework, pump and signal waves travel with identical group-velocity, which permits sustaining energy transfer in long aperiodically poled LiNbO<sub>3</sub> crystals (APPLN) even with ultrafast pulse duration. With the help of this structure, adiabatic frequency conversion shows extra advantages compared with the common cases, which enables lower stretching ratio and smoother gain spectrum...
December 26, 2016: Optics Express
(no author information available yet)
These abstracts are presented here as prepared by the authors. The accuracy and content of each abstract remain the responsibility of the authors. In the identification number above each abstract, OPO designates an Orthopaedic Section poster presentation. J Orthop Sports Phys Ther 2017;47(1):A58-A161. doi:10.2519/jospt.2017.47.1.A58.
January 2017: Journal of Orthopaedic and Sports Physical Therapy
Rodrigo F Alban, Bobby L Gibbons, Vanessa L Bershad
BACKGROUND: Organ availability is a consistently limiting factor in transplant surgery. A primary driver of this limitation is donor conversion rate, which is defined as the percentage of eligible donors for whom procurement is actually performed. An alternative way to increase organ availability is through improved utilization of organs from donors after cardiac death (DCD). Recently, a concerted, multidisciplinary effort has been made within our system to improve conversion rates and DCD utilization, thus increasing organ availability...
November 22, 2016: Curēus
Kavita Devi, S Chaitanya Kumar, M Ebrahim-Zadeh
We report a compact, fiber-laser-based, high-repetition-rate picosecond source for the ultraviolet (UV), providing multi-tens of milliwatt of average power across 329-348 nm. The source is based on internal sum-frequency-generation (SFG) in a singly resonant optical parametric oscillator (OPO), synchronously pumped at 532 nm by the second harmonic of a picosecond Yb-fiber laser at 80 MHz repetition rate. Using a 30-mm-long single-grating MgO:sPPLT crystal for the OPO and a 5-mm-long BiB<sub>3</sub>O<sub>6</sub> crystal for intracavity SFG, we generate up to 115 mW of average UV power at 339...
October 15, 2016: Optics Letters
Jeffrey P Orlowski
BACKGROUND:  In 2012, one organ procurement organization (OPO) welcomed a new President and Chief Executive Officer (CEO). This OPO, LifeShare Transplant Donor Services of Oklahoma (LifeShare), had just celebrated its 25th anniversary in 2011. While LifeShare was well-established chronologically, growth in organ donors and organs transplanted from these donors had occurred at a much slower rate during the collaborative era and afterward (2003-2011) than the donor/transplant growth the United States (US), as a whole, had experienced...
November 15, 2016: Curēus
Emre Arpali, Joseph R Scalea, Robert R Redfield, Lynn Berg, Dixon Kaufman, Hans W Sollinger, Bridget Welch, Glen Leverson, Jon S Odorico
BACKGROUND: Hemoglobin A1C (HbA1c) levels are often obtained in potential pancreas graft donors to assess the overall long-term functional glycemic control or the possibility of unrecognized diabetes. Although routinely measured, the impact of donor HbA1c levels on pancreas graft outcomes has not been reported. Here, we researched the relationship between donor HbA1c levels and postoperative pancreas graft survival. METHODS: Data from 266 pancreas transplant patients including 182 simultaneous kidney-pancreas and 84 pancreas alone transplants were reviewed for the study...
December 14, 2016: Transplantation
H M Traino, A J Molisani, L A Siminoff
Although federal mandate prohibits the allocation of solid organs for transplantation based on "accidents of geography," geographic variation of transplantable organs is well documented. This study explores regional differences in communication in requests for organ donation. Administrative data from 9 partnering Organ Procurement Organizations and interview data from 1,339 family decision makers (FDMs) were compared across 8 geographically distinct US donor service areas (DSA). Authorization to organ donation ranged from 60...
December 16, 2016: American Journal of Transplantation
K P Croome, D D Lee, A P Keaveny, C B Taner
Organ procurement organization (OPO) performance is generally evaluated by the number of organ procurement procedures divided by the number of eligible deaths (donation after brain death [DBD] donors aged <70 years), whereas the number of noneligible deaths (including donation after cardiac death donors and DBD donors aged >70 years) is not tracked. The present study aimed to investigate the variability in the proportion of noneligible liver donors by the 58 donor service areas (DSAs). Patients undergoing liver transplant (LT) between 2011 and 2015 were obtained from the United Network for Organ Sharing Standard Transplant Analysis and Research file...
December 15, 2016: American Journal of Transplantation
W K Chang, H P Chung, Y Y Chou, R Geiss, S D Yang, T Pertsch, Y H Chen
We report on the first building of an active spectral narrowing mechanism in a pulsed, multiline optical parametric oscillator (OPO) based on a novel aperiodically poled lithium niobate (APPLN) device constructed using the aperiodic optical superlattice technique. The APPLN device functions simultaneously in the system as a multi-channel optical parametric down converter (OPDC) and an electro-optic (EO) gain spectral filter working on the corresponding (multiple) signal bands. When the APPLN OPO was installed in a diode pumped Nd:YVO<sub>4</sub> laser system, highly narrowed dual-wavelength signal lines (at 1540 and 1550 nm) were observed at the output of the system through EO control of the APPLN...
December 12, 2016: Optics Express
Takahiro Serikawa, Jun-Ichi Yoshikawa, Kenzo Makino, Akira Frusawa
We report a 65 MHz-bandwidth triangular-shaped optical parametric oscillator (OPO) for squeezed vacuum generation at 860 nm. The triangle structure of our OPO enables the round-trip length to reach 45 mm as a ring cavity, which provides a counter circulating optical path available for introducing a probe beam or generating another squeezed vacuum. Hence our OPO is suitable for the applications in high-speed quantum information processing where two or more squeezed vacua form a complicated interferometer, like continuous-variable quantum teleportation...
December 12, 2016: Optics Express
Sapna Khowal, Md Zulquarnain Siddiqui, Shadab Ali, Mohd Taha Khan, Mather Ali Khan, Samar Husain Naqvi, Saima Wajid
The study involves isolation of arsenic resistant bacteria from soil samples. The characterization of bacteria isolates was based on 16S rRNA gene sequences. The phylogenetic consanguinity among isolates was studied employing rpoB and gltX gene sequence. RAPD-PCR technique was used to analyze genetic similarity between arsenic resistant isolates. In accordance with the results Bacillus subtilis and Bacillus pumilus strains may exhibit extensive horizontal gene transfer. Arsenic resistant potency in Bacillus sonorensis and high arsenite tolerance in Bacillus pumilus strains was identified...
December 10, 2016: Molecular Phylogenetics and Evolution
Vikram Kilambi, Sanjay Mehrotra
BACKGROUND: Geographic disparities persist in access to liver transplantation. Candidates with similar urgency experience varying opportunities for transplants across the United States. Policymakers are poised to act and 1 proposal entails reorganizing the current Organ Procurement and Transplant Network (OPTN) of 11 regions into 8 districts. However, redistricting has the shortcomings that Organ Procurement Organizations (OPOs) are disconnected from their immediate neighbors by district borders and that it is not easily responsive to uncertainty resulting from variability in donor and listing rates...
February 2017: Transplantation
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