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https://www.readbyqxmd.com/read/28739153/active-donor-management-during-the-hospital-phase-of-care-is-associated-with-more-organs-transplanted-per-donor
#1
Madhukar S Patel, Salvador De La Cruz, Mitchell B Sally, Tahnee Groat, Darren J Malinoski
BACKGROUND: Meeting donor management goals (DMGs) while caring for potential organ donors has been associated with more organs transplanted per donor (OTPD). Concern persists, however, as to whether this reflects that younger/healthier donors are more likely to meet DMGs or whether active management affects outcomes. STUDY DESIGN: A prospective observational study of all standard criteria donors (SCDs) was conducted by 10 organ procurement organizations across UNOS Regions 4, 5, and 6...
July 21, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28737972/identifying-health-information-technology-needs-of-oncologists-to-facilitate-the-adoption-of-genomic-medicine-recommendations-from-the-2016-american-society-of-clinical-oncology-omics-and-precision-oncology-workshop
#2
Kevin S Hughes, Edward P Ambinder, Gregory P Hess, Peter Paul Yu, Elmer V Bernstam, Mark J Routbort, Jean Rene Clemenceau, John T Hamm, Phillip G Febbo, Susan M Domchek, James L Chen, Jeremy L Warner
At the ASCO Data Standards and Interoperability Summit held in May 2016, it was unanimously decided that four areas of current oncology clinical practice have serious, unmet health information technology needs. The following areas of need were identified: 1) omics and precision oncology, 2) advancing interoperability, 3) patient engagement, and 4) value-based oncology. To begin to address these issues, ASCO convened two complementary workshops: the Omics and Precision Oncology Workshop in October 2016 and the Advancing Interoperability Workshop in December 2016...
July 24, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28726327/changing-metrics-of-organ-procurement-organization-performance-in-order-to-increase-organ-donation-rates-in-the-united-states
#3
D Goldberg, M J Kallan, L Fu, M Ciccarone, J Ramirez, P Rosenberg, J Arnold, G Segal, K P Moritsugu, H Nathan, R Hasz, P L Abt
The shortage of deceased-donor organs is compounded by donation metrics that fail to account for the total pool of possible donors, leading to ambiguous donor statistics. We sought to assess potential metrics of organ procurement organizations (OPOs) utilizing data from the Nationwide Inpatient Sample (NIS) from 2009-2012 and State Inpatient Databases (SIDs) from 2008-2014. A possible donor was defined as a ventilated inpatient death ≤75 years of age, without multi-organ system failure, sepsis, or cancer, whose cause of death was consistent with organ donation...
July 20, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28726257/statistical-review-recommendations-for-analysis-of-repeated-measures-designs-testing-and-correcting-for-sphericity-and-use-of-manova-and-mixed-model-analysis
#4
REVIEW
Richard A Armstrong
PURPOSE: A common experimental design in ophthalmic research is the repeated-measures design in which at least one variable is a within-subject factor. This design is vulnerable to lack of 'sphericity' which assumes that the variances of the differences among all possible pairs of within-subject means are equal. Traditionally, this design has been analysed using a repeated-measures analysis of variance (RM-anova) but increasingly more complex methods such as multivariate anova (manova) and mixed model analysis (MMA) are being used...
July 20, 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28708153/stabilization-of-femtosecond-optical-parametric-oscillators-for-infrared-frequency-comb-generation
#5
Markku Vainio, Lauri Halonen
A synchronously pumped optical parametric oscillator (SP-OPO) is one of the most common techniques to generate femtosecond frequency combs in the mid-infrared region. Stable long-term operation of an SP-OPO requires active locking of the OPO resonator round-trip time to the pump pulse interval. A simple modulation-free locking method based on stabilization of narrow-band frequency-doubled power of the SP-OPO output comb is demonstrated in this Letter. The method relies on the strong dependency of frequency-doubled power on spectral shape of the comb, leading to better stability of the comb envelope spectrum than the commonly used dither-and-lock method...
July 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28702932/phylogenetic-analysis-of-rabbit-haemorrhagic-disease-virus-rhdv-strains-isolated-in-poland
#6
Andrzej Fitzner, Wieslaw Niedbalski
The aim of this study was to characterise the nucleotide and amino acid sequence of complete genomes (7.5 kb) from RHDV strains isolated in Poland and estimate the genetic variability in different elements of the viral RNA. In addition, the sequence of Polish RHDV isolates isolated from 1988-2015 was compared with the sequences of other European RHDV, including the RHDVa and RHDV2/RHDVb subtypes. The complete sequence was developed by the compilation of partial nucleotide sequences. This sequence consisted of approximately 7428 nucleotides...
July 12, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28671657/a-high-performance-compact-photoacoustic-tomography-system-for-in-vivo-small-animal-brain-imaging
#7
Paul Kumar Upputuri, Vijitha Periyasamy, Sandeep Kumar Kalva, Manojit Pramanik
In vivo small-animal imaging has an important role to play in preclinical studies. Photoacoustic tomography (PAT) is an emerging hybrid imaging modality that shows great potential for both preclinical and clinical applications. Conventional optical parametric oscillator-based PAT (OPO-PAT) systems are bulky and expensive and cannot provide high-speed imaging. Recently, pulsed-laser diodes (PLDs) have been successfully demonstrated as an alternative excitation source for PAT. Pulsed-laser diode PAT (PLD-PAT) has been successfully demonstrated for high-speed imaging on photoacoustic phantoms and biological tissues...
June 21, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28634490/associations-of-pet-ownership-with-older-adults-eating-patterns-and-health
#8
Roschelle Heuberger
Pet ownership has been shown to improve quality of life for older adults. The objective of this cross-sectional study was to compare older pet owners and older non-pet owners and assess differences between groups. This study was conducted on adults over 50 years of age, who owned either one cat or one dog versus nonowners based on age, race, gender, and education. Matched older pet owners (OPO) versus non-pet owners (NPO) pairs (n = 84), older cat owners (OCO) versus non-cat owners (NCO) (n = 29), and older dog owners (ODO) versus non-dog owners (NDO) pairs (n = 55) were analyzed...
2017: Current Gerontology and Geriatrics Research
https://www.readbyqxmd.com/read/28569879/nanosecond-difference-frequency-generation-in-orientation-patterned-gallium-phosphide
#9
Junxiong Wei, S Chaitanya Kumar, Hanyu Ye, Kavita Devi, Peter G Schunemann, M Ebrahim-Zadeh
We report a tunable, single-pass, pulsed nanosecond difference-frequency generation (DFG) source based on the new semiconductor nonlinear material, orientation-patterned gallium phosphide (OP-GaP). The DFG source is realized by mixing the output signal of a nanosecond OPO tunable over 1723-1827 nm with the input pump pulses of the same OPO at 1064 nm in an OP-GaP crystal, resulting in tunable generation over 233 nm in the mid-infrared from 2548 to 2781 nm. Using a 40-mm-long crystal, we have produced ∼14  mW of average DFG output power at 2719 nm for a pump power of 5 W and signal power of 1 W at 80 kHz repetition rate...
June 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28514250/accept-or-decline-an-analytics-based-decision-tool-for-kidney-offer-evaluation
#10
Dimitris Bertsimas, Jerry Kung, Nikolaos Trichakis, David Wojciechowski, Parsia A Vagefi
BACKGROUND: When a deceased-donor kidney is offered to a waitlisted candidate, the decision to accept or decline the organ relies primarily upon a practitioner's experience and intuition. Such decisions must achieve a delicate balance between estimating the immediate benefit of transplantation and the potential for future higher-quality offers. However, the current experience-based paradigm lacks scientific rigor and is subject to the inaccuracies that plague anecdotal decision-making...
May 17, 2017: Transplantation
https://www.readbyqxmd.com/read/28465809/process-and-barriers-to-organ-donation-and-causes-of-brain-death-in-northeast-of-iran
#11
Abdollah Bahrami, Ebrahim Khaleghi, Ali Khorsand Vakilzadeh, Monavar Afzalaghaee
INTRODUCTION: Organ transplantation is the treatment of choice for some diseases. However, the need for cadaveric organ donation has either plateaued or is on a decreasing trend in some countries, especially in developed ones. In this study, we aimed to identify the barriers to organ donation in brain dead patients, who were referred to the organ procurement organizations (OPO) in northeast Iran. METHODS: In this cross-sectional study during 2006 to 2013, data were collected from medical records of brain dead patients...
February 2017: Electronic Physician
https://www.readbyqxmd.com/read/28414351/phase-matching-properties-of-baga-sub-4-sub-se-sub-7-sub-for-shg-and-sfg-in-the-0-901-10-5910%C3%A2-%C3%A2-%C3%AE-m-range
#12
Kiyoshi Kato, Kentaro Miyata, Valentin Petrov
We report new experimental results on the phase-matching properties of a BaGa<sub>4</sub>Se<sub>7</sub> crystal for harmonic generation of a Nd:YAG laser-pumped AgGaS<sub>2</sub> optical parametric oscillator (OPO) and a CO<sub>2</sub> laser in the 0.901-10.5910 μm range. In addition, we present new Sellmeier equations that provide a good reproduction of the present experimental results as well as the published data points for a Nd:YAG laser-pumped OPO and an optical parametric amplifier (OPA) in the 3...
April 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/28397363/improved-time-to-notification-of-impending-brain-death-and-increased-organ-donation-using-an-electronic-clinical-decision-support-system
#13
J L Zier, A B Spaulding, M Finch, T Verschaetse, R Tarrago
Early referral of patients to an organ procurement organization (OPO) may positively affect donation outcomes. We implemented an electronic clinic decision support (CDS) system to automatically notify our OPO of children meeting clinical triggers indicating impending brain death. Medical records of all patients who died in a pediatric critical care unit or were referred for imminent death for 3 years prior to installation of the initial CDS (pre-CDS) and for 1 year after implementation of the final CDS (post-CDS) were reviewed...
August 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28380765/higher-order-mode-entanglement-in-a-type-ii-optical-parametric-oscillator
#14
Jun Guo, Chunxiao Cai, Long Ma, Kui Liu, Hengxin Sun, Jiangrui Gao
Nonclassical beams in high order spatial modes have attracted much interest but they exhibit much less squeezing and entanglement than the fundamental spatial modes, limiting their applications. We experimentally demonstrate the relation between pump modes and entanglement of first-order Hermite Gauss modes (HG<sub>10</sub> entangled states) in a type II OPO and show that the maximum entanglement of high order spatial modes can be obtained by optimizing the pump spatial mode. To our knowledge, this is the first time to report this...
March 6, 2017: Optics Express
https://www.readbyqxmd.com/read/28380740/frequency-comb-assisted-two-photon-vibrational-spectroscopy
#15
Juho Karhu, Markku Vainio, Markus Metsälä, Lauri Halonen
We report a setup for high-resolution two-photon spectroscopy using a mid-infrared continuous wave optical parametric oscillator (CW-OPO) and a near-infrared diode laser as the excitation sources, both of which are locked to fully stabilized optical frequency combs. The diode laser is directly locked to a commercial near-infrared optical frequency comb using an optical phase-locked loop. The near-infrared frequency comb is also used to synchronously pump a degenerate femtosecond optical parametric oscillator to produce a fully stabilized mid-infrared frequency comb...
March 6, 2017: Optics Express
https://www.readbyqxmd.com/read/28372437/fast-precise-and-widely-tunable-frequency-control-of-an-optical-parametric-oscillator-referenced-to-a-frequency-comb
#16
Alexander Prehn, Rosa Glöckner, Gerhard Rempe, Martin Zeppenfeld
Optical frequency combs (OFCs) provide a convenient reference for the frequency stabilization of continuous-wave lasers. We demonstrate a frequency control method relying on tracking over a wide range and stabilizing the beat note between the laser and the OFC. The approach combines fast frequency ramps on a millisecond timescale in the entire mode-hop free tuning range of the laser and precise stabilization to single frequencies. We apply it to a commercially available optical parametric oscillator (OPO) and demonstrate tuning over more than 60 GHz with a ramping speed up to 3 GHz/ms...
March 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28364665/doppler-limited-high-resolution-spectrum-and-vpt2-assisted-assignment-of-the-c-h-stretch-of-ch2br2
#17
Ibrahim Sadiek, Gernot Friedrichs
The Doppler limited non-saturated rotationally resolved infrared spectra of the symmetric and asymmetric CH-stretch bands of CH2Br2 have been measured. A continuous wave cavity ringdown setup with a widely tunable Mid-IR-OPO laser light source yielded a single-shot minimum absorption of 4.9×10(-8)cm(-1). In contrast to the heavily congested ν1 band, the ν6 band showed partially resolved rotational features that may serve as suitable absorption targets in future environmental detection schemes for CH2Br2...
March 16, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28317752/facile-preparation-of-magnetic-carbon-nanotubes-immobilized-lipase-for-highly-efficient-synthesis-of-1-3-dioleoyl-2-palmitoylglycerol-rich-human-milk-fat-substitutes
#18
Mingming Zheng, Shi Wang, Xia Xiang, Jie Shi, Juan Huang, Qianchun Deng, Fenghong Huang, Junyong Xiao
In this study, Candida lipolytica lipase (CLL) was immobilized on magnetic multi-walled carbon nanotubes (mMWCNTs) via hydrophobic and cation-exchange interaction. The resultant immobilized CLL showed much better thermal stability, biocatalyst activity and easier recycling than the free form. A method for efficient enzymatic acidolysis of tripalmitin (PPP) with oleic acid (OA), to produce OPO-rich TAGs, was developed, using the immobilized CLL as the biocatalyst. Under optimized conditions (2% water, 20mg/ml enzyme, 1:6 PPP/OA, 50°C, 2h), the content of OPO in the final product reached 46...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28262823/multi-gigahertz-femtosecond-airy-beam-optical-parametric-oscillator-pumped-at-78-mhz
#19
A Aadhi, Varun Sharma, N Apurv Chaitanya, G K Samanta
We report a high power ultrafast Airy beam source producing femtosecond pulses at multi-gigahertz (GHz) repetition rate (RR). Based on intra-cavity cubic phase modulation of an optical parametric oscillator (OPO) designed in high harmonic cavity configuration synchronous to a femtosecond Yb-fiber laser operating at 78 MHz, we have produced ultrafast 2D Airy beam at multi-GHz repetition rate through the fractional increment in the cavity length. While small (<1 mm) crystals are used in femtosecond OPOs to take the advantage of broad phase-matching bandwidth, here, we have exploited the extended phase-matching bandwidth of a 50-mm long Magnesium-oxide doped periodically poled LiNbO3 (MgO:PPLN) crystal for efficient generation of ultrafast Airy beam and broadband mid-IR radiation...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28241627/hybrid-q-switched-laser-with-mos-sub-2-sub-saturable-absorber-and-aom-driven-sub-nanosecond-ktp-opo
#20
Junpeng Qiao, Shengzhi Zhao, Kejian Yang, Jia Zhao, Guiqiu Li, Dechun Li, Tao Li, Wenchao Qiao
Two-dimensional (2D) materials, especially transition-metal dichalcogenides, such as molybdenum disulfide (MoS<sub>2</sub>) and tungsten disulfide (WS<sub>2</sub>), have attracted great interests due to their exceptional optical properties as saturable absorbers in laser systems. In this work, at first, we presented a diode-pumped passively Q-switched laser with MoS<sub>2</sub> saturable absorber (MoS<sub>2</sub>-SA). At an incident pump power of 6.54 W, a maximum output power of 1...
February 20, 2017: Optics Express
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