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https://www.readbyqxmd.com/read/28985863/early-declaration-of-death-by-neurologic-criteria-results-in-greater-organ-donor-potential
#1
Shelby Resnick, Mark J Seamon, Daniel Holena, Jose Pascual, Patrick M Reilly, Niels D Martin
BACKGROUND: Aggressive management of patients prior to and after determination of death by neurologic criteria (DNC) is necessary to optimize organ recovery, transplantation, and increase the number of organs transplanted per donor (OTPD). The effects of time management are understudied but potentially pivotal component. The objective of this study was to analyze specific time points (time to DNC, time to procurement) and the time intervals between them to better characterize the optimal timeline of organ donation...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28981193/organ-utilization-from-increased-infectious-risk-donors-an-observational-study
#2
Arnaud G L'Huillier, Atul Humar, Clare Payne, Deepali Kumar
BACKGROUND: Donors with an increased risk of transmitting human immunodeficiency virus (HIV), hepatitis B virus (HBV), or hepatitis C virus (HCV) (increased risk donors [IRDs]) are a potential source of organs for transplant. Organs from IRDs can be utilized with appropriate recipient consent and post-transplant follow-up. We reviewed the characteristics and utilization of IRDs in our Organ Procurement Organization (OPO) over a 2-year period. METHODS: Donor information from April 1, 2013 to March 31, 2015 was obtained through the OPO database...
October 5, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28963201/draft-genome-sequences-of-three-novel-low-abundance-species-strains-isolated-from-kefir-grain
#3
Yongkyu Kim, Sonja Blasche, Kiran R Patil
We report here the genome sequences of three novel bacterial species strains-Bacillus kefirresidentii Opo, Rothia kefirresidentii KRP, and Streptococcus kefirresidentii YK-isolated from kefir grains collected in Germany. The draft genomes of these isolates were remarkably dissimilar (average nucleotide identities, 77.80%, 89.01%, and 92.10%, respectively) to those of the previously sequenced strains.
September 28, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28957303/room-temperature-rapidly-tunable-green-pumped-continuous-wave-optical-parametric-oscillator
#4
Kavita Devi, M Ebrahim-Zadeh
We report a high-power, single-frequency, green-pumped continuous-wave optical parametric oscillator (OPO) capable of providing rapid and continuous tuning across a wide spectral range in the near-infrared at room temperature. By exploiting the nonlinear crystal of MgO:sPPLT in a fan-out grating design pumped at 532 nm in the green, the OPO can be tuned continuously across 1097-2100 nm in the idler, with corresponding signal tuning over 712-1033 nm using simple mechanical translation of the crystal at fixed temperature...
July 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28949897/consent-for-organ-donation-after-circulatory-death-at-u-s-transplant-centers
#5
George E Hardart, Matthew K Labriola, Kenneth Prager, Marilyn C Morris
BACKGROUND: Despite calls for a controlled organ donation after circulatory death (cDCD) consent process that is more rigorous, consistent, and transparent, little is known about the cDCD consent processes utilized by U.S. hospitals. The objective of this research was to describe the cDCD consent policies of U.S. transplant hospitals, including consent for antemortem interventions (AMI), in order to inform the development of a more rigorous and sound consent process. METHODS: Cross-sectional study data of cDCD policies of U...
July 2017: AJOB Empirical Bioethics
https://www.readbyqxmd.com/read/28941082/liver-biopsy-in-assessment-of-extended-criteria-donors
#6
Joseph B Oliver, Praveena Machineni, Advaith Bongu, Trusha Patel, Joseph Nespral, Carie Kadric, Michael J Goldstein, Harvey Lerner, David Gee, Richard Hillbom, Lloyd Brown, Kenneth Washburn, Baburao Koneru
INTRODUCTION: The safety and liver utilization with prerecovery liver biopsy (PLB) in extended criteria liver donors are unclear. METHODS: We conducted a retrospective cohort study in 1323 brain death donors (PLB=496) from three organ procurement organizations (OPOs). Outcomes were complications, preemption of liver recovery (PLR) and livers transplanted (LT). Additional analyses included liver only and propensity score-matched multiorgan donor subgroups. RESULTS: PLB donors were older (57yrs vs 53yrs, p<0...
September 21, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28938312/long-cold-ischemia-times-in-same-hospital-deceased-donor-transplants
#7
Eric Kh Chow, Sandra DiBrito, Xun Luo, Corey Wickliffe, Allan B Massie, Jayme E Locke, Sommer E Gentry, Jacqueline Garonzik-Wang, Dorry L Segev
BACKGROUND: Recent changes in deceased donor organ allocation for livers (Share-35) and kidneys (KAS) have resulted in broader sharing of organs and increased cold ischemia time (CIT). Broader organ sharing however is not the only cause of increased CIT. METHODS: This was a retrospective registry study of CIT in same-hospital liver transplants (SHLT, n=4,347) and kidney transplants (SHKT, n=9,707) between 2004 and 2014. RESULTS: In SHLT, median (IQR) CIT was 5...
September 20, 2017: Transplantation
https://www.readbyqxmd.com/read/28914913/high-repetition-rate-deep-infrared-picosecond-optical-parametric-oscillator-based-on-cdsip2
#8
S Chaitanya Kumar, K T Zawilski, P G Schunemann, M Ebrahim-Zadeh
We report a high-repetition-rate picosecond optical parametric oscillator (OPO) based on CdSiP2 (CSP) that is synchronously pumped by an Yb-fiber laser at 1064 nm and provides high average power in the deep-infrared (deep-IR) at 79.5 MHz. The OPO is tunable across 6205-6710 nm in the idler, providing as much as 105 mW of average power at 6205 nm and >55  mW over nearly the entire tuning range. The deep-IR idler output exhibits passive power stability better than 2.3% rms over 12 h in good beam quality...
September 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28739153/active-donor-management-during-the-hospital-phase-of-care-is-associated-with-more-organs-transplanted-per-donor
#9
Madhukar S Patel, Salvador De La Cruz, Mitchell B Sally, Tahnee Groat, Darren J Malinoski
BACKGROUND: Meeting donor management goals when caring for potential organ donors has been associated with more organs transplanted per donor (OTPD). Concern persists, however, as to whether this indicates that younger/healthier donors are more likely to meet donor management goals or whether active management affects outcomes. STUDY DESIGN: A prospective observational study of all standard criteria donors was conducted by 10 organ procurement organizations across United Network for Organ Sharing Regions 4, 5, and 6...
October 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28737972/identifying-health-information-technology-needs-of-oncologists-to-facilitate-the-adoption-of-genomic-medicine-recommendations-from-the-2016-american-society-of-clinical-oncology-omics-and-precision-oncology-workshop
#10
Kevin S Hughes, Edward P Ambinder, Gregory P Hess, Peter Paul Yu, Elmer V Bernstam, Mark J Routbort, Jean Rene Clemenceau, John T Hamm, Phillip G Febbo, Susan M Domchek, James L Chen, Jeremy L Warner
At the ASCO Data Standards and Interoperability Summit held in May 2016, it was unanimously decided that four areas of current oncology clinical practice have serious, unmet health information technology needs. The following areas of need were identified: 1) omics and precision oncology, 2) advancing interoperability, 3) patient engagement, and 4) value-based oncology. To begin to address these issues, ASCO convened two complementary workshops: the Omics and Precision Oncology Workshop in October 2016 and the Advancing Interoperability Workshop in December 2016...
September 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28726327/changing-metrics-of-organ-procurement-organization-performance-in-order-to-increase-organ-donation-rates-in-the-united-states
#11
D Goldberg, M J Kallan, L Fu, M Ciccarone, J Ramirez, P Rosenberg, J Arnold, G Segal, K P Moritsugu, H Nathan, R Hasz, P L Abt
The shortage of deceased-donor organs is compounded by donation metrics that fail to account for the total pool of possible donors, leading to ambiguous donor statistics. We sought to assess potential metrics of organ procurement organizations (OPOs) utilizing data from the Nationwide Inpatient Sample (NIS) from 2009-2012 and State Inpatient Databases (SIDs) from 2008-2014. A possible donor was defined as a ventilated inpatient death ≤75 years of age, without multi-organ system failure, sepsis, or cancer, whose cause of death was consistent with organ donation...
July 20, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28726257/recommendations-for-analysis-of-repeated-measures-designs-testing-and-correcting-for-sphericity-and-use-of-manova-and-mixed-model-analysis
#12
REVIEW
Richard A Armstrong
PURPOSE: A common experimental design in ophthalmic research is the repeated-measures design in which at least one variable is a within-subject factor. This design is vulnerable to lack of 'sphericity' which assumes that the variances of the differences among all possible pairs of within-subject means are equal. Traditionally, this design has been analysed using a repeated-measures analysis of variance (RM-anova) but increasingly more complex methods such as multivariate anova (manova) and mixed model analysis (MMA) are being used...
September 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28708153/stabilization-of-femtosecond-optical-parametric-oscillators-for-infrared-frequency-comb-generation
#13
Markku Vainio, Lauri Halonen
A synchronously pumped optical parametric oscillator (SP-OPO) is one of the most common techniques to generate femtosecond frequency combs in the mid-infrared region. Stable long-term operation of an SP-OPO requires active locking of the OPO resonator round-trip time to the pump pulse interval. A simple modulation-free locking method based on stabilization of narrow-band frequency-doubled power of the SP-OPO output comb is demonstrated in this Letter. The method relies on the strong dependency of frequency-doubled power on spectral shape of the comb, leading to better stability of the comb envelope spectrum than the commonly used dither-and-lock method...
July 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28702932/phylogenetic-analysis-of-rabbit-haemorrhagic-disease-virus-rhdv-strains-isolated-in-poland
#14
Andrzej Fitzner, Wieslaw Niedbalski
The aim of this study was to characterise the nucleotide and amino acid sequence of complete genomes (7.5 kb) from RHDV strains isolated in Poland and estimate the genetic variability in different elements of the viral RNA. In addition, the sequence of Polish RHDV isolates isolated from 1988-2015 was compared with the sequences of other European RHDV, including the RHDVa and RHDV2/RHDVb subtypes. The complete sequence was developed by the compilation of partial nucleotide sequences. This sequence consisted of approximately 7428 nucleotides...
July 12, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28671657/a-high-performance-compact-photoacoustic-tomography-system-for-in-vivo-small-animal-brain-imaging
#15
Paul Kumar Upputuri, Vijitha Periyasamy, Sandeep Kumar Kalva, Manojit Pramanik
In vivo small-animal imaging has an important role to play in preclinical studies. Photoacoustic tomography (PAT) is an emerging hybrid imaging modality that shows great potential for both preclinical and clinical applications. Conventional optical parametric oscillator-based PAT (OPO-PAT) systems are bulky and expensive and cannot provide high-speed imaging. Recently, pulsed-laser diodes (PLDs) have been successfully demonstrated as an alternative excitation source for PAT. Pulsed-laser diode PAT (PLD-PAT) has been successfully demonstrated for high-speed imaging on photoacoustic phantoms and biological tissues...
June 21, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28634490/associations-of-pet-ownership-with-older-adults-eating-patterns-and-health
#16
Roschelle Heuberger
Pet ownership has been shown to improve quality of life for older adults. The objective of this cross-sectional study was to compare older pet owners and older non-pet owners and assess differences between groups. This study was conducted on adults over 50 years of age, who owned either one cat or one dog versus nonowners based on age, race, gender, and education. Matched older pet owners (OPO) versus non-pet owners (NPO) pairs (n = 84), older cat owners (OCO) versus non-cat owners (NCO) (n = 29), and older dog owners (ODO) versus non-dog owners (NDO) pairs (n = 55) were analyzed...
2017: Current Gerontology and Geriatrics Research
https://www.readbyqxmd.com/read/28569879/nanosecond-difference-frequency-generation-in-orientation-patterned-gallium-phosphide
#17
Junxiong Wei, S Chaitanya Kumar, Hanyu Ye, Kavita Devi, Peter G Schunemann, M Ebrahim-Zadeh
We report a tunable, single-pass, pulsed nanosecond difference-frequency generation (DFG) source based on the new semiconductor nonlinear material, orientation-patterned gallium phosphide (OP-GaP). The DFG source is realized by mixing the output signal of a nanosecond OPO tunable over 1723-1827 nm with the input pump pulses of the same OPO at 1064 nm in an OP-GaP crystal, resulting in tunable generation over 233 nm in the mid-infrared from 2548 to 2781 nm. Using a 40-mm-long crystal, we have produced ∼14  mW of average DFG output power at 2719 nm for a pump power of 5 W and signal power of 1 W at 80 kHz repetition rate...
June 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28514250/accept-or-decline-an-analytics-based-decision-tool-for-kidney-offer-evaluation
#18
Dimitris Bertsimas, Jerry Kung, Nikolaos Trichakis, David Wojciechowski, Parsia A Vagefi
BACKGROUND: When a deceased-donor kidney is offered to a waitlisted candidate, the decision to accept or decline the organ relies primarily upon a practitioner's experience and intuition. Such decisions must achieve a delicate balance between estimating the immediate benefit of transplantation and the potential for future higher-quality offers. However, the current experience-based paradigm lacks scientific rigor and is subject to the inaccuracies that plague anecdotal decision-making...
May 17, 2017: Transplantation
https://www.readbyqxmd.com/read/28465809/process-and-barriers-to-organ-donation-and-causes-of-brain-death-in-northeast-of-iran
#19
Abdollah Bahrami, Ebrahim Khaleghi, Ali Khorsand Vakilzadeh, Monavar Afzalaghaee
INTRODUCTION: Organ transplantation is the treatment of choice for some diseases. However, the need for cadaveric organ donation has either plateaued or is on a decreasing trend in some countries, especially in developed ones. In this study, we aimed to identify the barriers to organ donation in brain dead patients, who were referred to the organ procurement organizations (OPO) in northeast Iran. METHODS: In this cross-sectional study during 2006 to 2013, data were collected from medical records of brain dead patients...
February 2017: Electronic Physician
https://www.readbyqxmd.com/read/28414351/phase-matching-properties-of-baga-sub-4-sub-se-sub-7-sub-for-shg-and-sfg-in-the-0-901-10-5910%C3%A2-%C3%A2-%C3%AE-m-range
#20
Kiyoshi Kato, Kentaro Miyata, Valentin Petrov
We report new experimental results on the phase-matching properties of a BaGa<sub>4</sub>Se<sub>7</sub> crystal for harmonic generation of a Nd:YAG laser-pumped AgGaS<sub>2</sub> optical parametric oscillator (OPO) and a CO<sub>2</sub> laser in the 0.901-10.5910 μm range. In addition, we present new Sellmeier equations that provide a good reproduction of the present experimental results as well as the published data points for a Nd:YAG laser-pumped OPO and an optical parametric amplifier (OPA) in the 3...
April 10, 2017: Applied Optics
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