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Ali Hariri, Jeanne Lemaster, Junxin Wang, AnanthaKrishnan S Jeevarathinam, Daniel L Chao, Jesse V Jokerst
Photoacoustic imaging (PAI) is a non-invasive, high-resolution hybrid imaging modality that combines optical excitation and ultrasound detection. PAI can image endogenous chromophores (melanin, hemoglobin, etc.) and exogenous contrast agents in different medical applications. However, most current equipment uses sophisticated and complicated OPO lasers with tuning and stability features inconsistent with broad clinical deployment. As the number of applications of PAI in medicine increases, there is an urgent need to make the imaging equipment more compact, portable, and affordable...
March 2018: Photoacoustics
Malay B Shah, Valery Vilchez, Adam Goble, Michael F Daily, Jonathan C Berger, Roberto Gedaly, Derek A DuBay
BACKGROUND: Despite numerous initiatives to increase solid organs for transplant, the gap between donors and recipients widens. There is little in the literature identifying socioeconomic predictors for donation. We evaluate the correlation between socioeconomic factors and familial authorization for donation. METHODS: A retrospective analysis of adult potential donor referrals between 2007 and 2012 to our organ procurement organization (OPO) was performed. Potential donor information was obtained from the OPO database, death certificates, and the US Census Report...
January 2018: Journal of Surgical Research
Patricia A Webster, Lori E Markham
CONTEXT: Patients never declared brain dead may represent an additional source of donor organs. OBJECTIVE: To determine the number of likely brain dead potential donors who are never declared brain dead and to compare them with brain dead and donation after cardiac death potential organ donors. DESIGN, SETTING, AND PARTICIPANTS: This study was a retrospective chart review of all catastrophically brain-injured patients referred to a single-organ procurement organization (OPO) over a 4-year period...
January 1, 2017: Progress in Transplantation
Haris Riris, Kenji Numata, Stewart Wu, Brayler Gonzalez, Michael Rodriguez, Stan Scott, Stephan Kawa, Jianping Mao
We report on an airborne demonstration of atmospheric methane (CH4) measurements with an Integrated Path Differential Absorption (IPDA) lidar using an optical parametric amplifier (OPA) and optical parametric oscillator (OPO) laser transmitter and sensitive avalanche photodiode detector. The lidar measures the atmospheric CH4 absorption at multiple, discrete wavelengths near 1650.96 nm. The instrument was deployed in the fall of 2015, aboard NASA's DC-8 airborne laboratory along with an in-situ spectrometer and measured CH4 over a wide range of surfaces and atmospheric conditions from altitudes of 2 km to 13 km...
July 2017: Journal of Applied Remote Sensing
Napoleon Waszkiewicz, Beata Galińska-Skok, Anna Zalewska, Sławomir Dariusz Szajda, Krzysztof Zwierz, Magdalena Więdłocha, Agata Szulc
BACKGROUND: We compared effects of binge and chronic alcohol drinking on oral health and salivary immunity proteins. METHODS: The study involved males: 13 healthy social-drinking (C), 10 alcohol-dependent after chronic alcohol-intoxication (A), and 8 binge-drinkers after a single binge-drinking session (B). We compared periodontal/dental state and salivary immune proteins (lactoferrin -Lf, lysozyme -Lz, oral peroxidase -OPO, immunoglobulin A -IgA) in all groups...
December 1, 2017: Drug and Alcohol Dependence
Ayla Cash, Xun Luo, Eric K H Chow, Mary Grace Bowring, Ashton A Shaffer, Brianna Doby, Corey E Wickliffe, Charles Alexander, Deborah McRann, Aaron A R Tobian, Dorry L Segev, Christine M Durand
BACKGROUND: HIV-infected (HIV+) donor organs can be transplanted into HIV+ recipients under the HIV Organ Policy Equity (HOPE) Act. Quantifying HIV+ donor referrals received by Organ Procurement Organizations (OPOs) is critical for HOPE Act implementation. METHODS: We surveyed the 58 US OPOs regarding HIV+ referral records and newly discovered HIV+ donors. Using data from OPOs that provided exact records and CDC HIV prevalence data, we projected a national estimate of HIV+ referrals...
December 9, 2017: Clinical Transplantation
Magdalena Sałdyka, Zofia Mielke
The products formed during exposure of the CH3CONHOH/Ar (AHA/Ar) matrices to the full output of the Xe lamp and to 225 nm OPO radiation are studied. The irradiation promotes the isomerization, 1Z -1E, and AHA photodissociation reactions. Four pairs of co-products are experimentally found to appear in the photolysis, they form the complexes: CH3OH-HNCO (1), H2O-CH3NCO (2), H2O-CH3CNO (3) and CO-CH3NHOH (4). The structures of the complexes were optimized at the MP2 computational level with the 6-311++G(2d,2p) and aug-cc-pVTZ basis sets...
December 7, 2017: Journal of Physical Chemistry. A
C González-Arciniegas, Nicolas Treps, P Nussenzveig
We investigate quantum properties of light in optical parametric oscillators (OPOs) based on four-wave mixing gain in media with third-order nonlinearities. In spite of other competing χ(3) effects such as phase modulation, bipartite and tripartite entanglement is predicted above threshold. These findings are relevant for recent implementations of complementary metal-oxide-semiconductor (CMOS)-compatible on-chip OPOs.
December 1, 2017: Optics Letters
Maureen Wilson-Genderson, K Laura Barker, Heather M Gardiner, Maghboeba Mosavel, Jeffrey Thomas, Laura A Siminoff
Tissues from deceased donors provide important data for genomic research and Organ Procurement Organizations (OPOs) play a significant role. To understand the decisions of families who donated for transplantation and made decisions about donation to the Genotype-Tissue Expression Project (GTEx), we examined donation decisions of family decision makers (FDMs). 413 families were interviewed by telephone. The OPO staff who made the transplant and research requests completed self-administered surveys; a total of 309 matching surveys from 99 OPO staff were obtained...
December 4, 2017: Human Genetics
Nicole Theodoropoulos, Marek J Nowicki, Claudia Chinchilla-Reyes, Sara Dionne, Andrés Jaramillo, Tom Mone, Richard Hasz, Martin D Jendrisak, Daniela P Ladner, Michael G Ison
BACKGROUND: Before the 2014 policy change pertaining to infectious disease screening, many organ procurement organizations (OPOs) were supplementing serologic screening of deceased organ donors with nucleic acid testing (NAT) for human immunodeficiency virus (HIV-1), hepatitis B virus (HBV), and hepatitis C virus (HCV). The number of seronegative, NAT-positive donors has not been directly measured. METHODS: HIV, HBV, and HCV screening results of 11 229 donor referrals evaluated from 2010 to 2013 were obtained from three OPO-affiliated laboratories, capturing 35% of all donors in the United States...
November 27, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Qitian Ru, Zachary E Loparo, XiaoSheng Zhang, Sean Crystal, Subith Vasu, Peter G Schunemann, Konstantin L Vodopyanov
We report an octave-wide mid-IR spectrum (2.3-4.8 μm) obtained from a subharmonic optical parametric oscillator (OPO) based on a newly developed nonlinear crystal, orientation-patterned gallium phosphide (OP-GaP), which was synchronously pumped by a femtosecond 1560 nm fiber laser. We proved that the octave-wide output is in the form of a single frequency comb. The observed f-to-2f frequency beats, originating directly from the OPO, can be used for self-referencing and phase locking of the pump laser comb with no need for supercontinuum generation...
November 15, 2017: Optics Letters
Linda Rolfö, Jörgen Eklund, Helena Jahncke
Many companies move from open-plan offices (OPO) to activity-based workplaces (ABWs). However, few studies examine the benefits and drawbacks following such a change. The aim of this study was to explore how physical conditions, office use, communication, privacy, territoriality, satisfaction and perceived performance change following a company's relocation from an OPO to an ABW. A mixed methods approach included pre- and post-relocation questionnaires and post-relocation focus groups, individual interviews and observations...
November 16, 2017: Ergonomics
Toshiharu Nagai, Keiko Ishikawa, Kazuaki Yoshinaga, Akihiko Yoshida, Fumiaki Beppu, Naohiro Gotoh
The composition of triacylglycerol (TAG) positional isomer (-PI) and enantiomer (-E) in immature chicken egg yolk, mature chicken yolk, and chicken meat was examined. POO (consisting of one palmitic acid (P) and two oleic acids (Os)), PPO (consisting of two Ps and one O), and PPL (consisting of two Ps and one linoleic acid (L)) were treated as representative TAG molecular species in all the analytical samples because P, O, and L were the major fatty acids comprising egg and chicken meat. sn-POO (binding P at sn-1 position) was predominant in egg yolks, while sn-OOP and sn-OPO were present in chicken meat...
November 13, 2017: Journal of Oleo Science
R R Wu, L A Hamlow, C C He, Y-W Nei, G Berden, J Oomens, M T Rodgers
The gas-phase conformations of the protonated forms of thymidine-5'-monophosphate and uridine-5'-monophosphate, [pdThd+H](+) and [pUrd+H](+), are investigated by infrared multiple photon dissociation (IRMPD) action spectroscopy and electronic structure calculations. The IRMPD action spectra of [pdThd+H](+) and [pUrd+H](+) are measured over the IR fingerprint and hydrogen-stretching regions using the FELIX free electron laser and an OPO/OPA laser system. Low-energy conformations of [pdThd+H](+) and [pUrd+H](+) and their relative stabilities are computed at the MP2(full)/6-311+G(2d,2p)//B3LYP/6-311+G(d,p) and B3LYP/6-311+G(2d,2p)//B3LYP/6-311+G(d,p) levels of theory...
November 22, 2017: Physical Chemistry Chemical Physics: PCCP
Mahbube Khabbaz, Mohammad Sabaeian, Hamid Nadgaran
In this paper, a model describing the thermal effects on the optical parametric oscillator (OPO) of Gaussian continuous waves in double-pass cavities is presented. Eight equations, including forward and backward nonlinear waves, heat, and thermally induced phase mismatching equations, were coupled and solved simultaneously to investigate the effect of heat generation on the OPO's efficiency. The model was applied for a periodically poled MgO:LiNbO3 crystal with an excellent agreement with experimental data...
August 10, 2017: Applied Optics
J C Casals, S Parsa, S Chaitanya Kumar, K Devi, P G Schunemann, M Ebrahim-Zadeh
We report the generation of tunable high-repetition-rate picosecond radiation in the mid-infrared using the new quasi-phase-matched nonlinear material of orientation-patterned gallium phosphide (OP-GaP). The source is realized by single-pass difference-frequency-generation (DFG) between the output signal of a picosecond optical parametric oscillator (OPO) tunable across 1609-1637 nm with input pump pulses at 1064 nm in OP-GaP, resulting in tunable radiation across 3040-3132 nm. Using a 40-mm-long crystal, we have generated up to 57 mW of DFG average power at ~80 MHz repetition rate for a pump power of 5 W and signal power of 0...
August 7, 2017: Optics Express
Shelby Resnick, Mark J Seamon, Daniel Holena, Jose Pascual, Patrick M Reilly, Niels D Martin
BACKGROUND: Aggressive management of patients prior to and after determination of death by neurologic criteria (DNC) is necessary to optimize organ recovery, transplantation, and increase the number of organs transplanted per donor (OTPD). The effects of time management are understudied but potentially pivotal component. The objective of this study was to analyze specific time points (time to DNC, time to procurement) and the time intervals between them to better characterize the optimal timeline of organ donation...
October 2017: Journal of Surgical Research
Arnaud G L'Huillier, Atul Humar, Clare Payne, Deepali Kumar
BACKGROUND: Donors with an increased risk of transmitting human immunodeficiency virus (HIV), hepatitis B virus (HBV), or hepatitis C virus (HCV) (increased risk donors [IRDs]) are a potential source of organs for transplant. Organs from IRDs can be utilized with appropriate recipient consent and post-transplant follow-up. We reviewed the characteristics and utilization of IRDs in our Organ Procurement Organization (OPO) over a 2-year period. METHODS: Donor information from April 1, 2013 to March 31, 2015 was obtained through the OPO database...
October 5, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Yongkyu Kim, Sonja Blasche, Kiran R Patil
We report here the genome sequences of three novel bacterial species strains-Bacillus kefirresidentii Opo, Rothia kefirresidentii KRP, and Streptococcus kefirresidentii YK-isolated from kefir grains collected in Germany. The draft genomes of these isolates were remarkably dissimilar (average nucleotide identities, 77.80%, 89.01%, and 92.10%, respectively) to those of the previously sequenced strains.
September 28, 2017: Genome Announcements
Kavita Devi, M Ebrahim-Zadeh
We report a high-power, single-frequency, green-pumped continuous-wave optical parametric oscillator (OPO) capable of providing rapid and continuous tuning across a wide spectral range in the near-infrared at room temperature. By exploiting the nonlinear crystal of MgO:sPPLT in a fan-out grating design pumped at 532 nm in the green, the OPO can be tuned continuously across 1097-2100 nm in the idler, with corresponding signal tuning over 712-1033 nm using simple mechanical translation of the crystal at fixed temperature...
July 1, 2017: Optics Letters
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