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https://www.readbyqxmd.com/read/29470473/liver-abscess-contemporary-presentation-and-management-in-a-western-population
#1
Kareem Osman, Sanket Srinivasa, Jonathan Koea
AIM: Historically, liver abscesses (LA) affected elderly, immunocompromised patients and were characterised by high morbidity and mortality, however there are no data pertaining to a New Zealand population with little information surrounding recent management trends. METHODS: A retrospective review of demographic characteristics, clinical management and microbiological data on patients presenting with liver abscess between 2005-2014 was conducted. RESULTS: Fifty-seven patients [37 males, median age 64 (range 15-87)] presented with LA and most patients were not comorbid...
February 23, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29466409/il-7-treatment-augments-and-prolongs-sepsis-induced-expansion-of-il-10-producing-b-lymphocytes-and-myeloid-derived-suppressor-cells
#2
Upasana Kulkarni, Christoph Herrmenau, Stephanie J Win, Michael Bauer, Thomas Kamradt
Immunological dysregulation in sepsis is associated with often lethal secondary infections. Loss of effector cells and an expansion of immunoregulatory cell populations both contribute to sepsis-induced immunosuppression. The extent and duration of this immunosuppression are unknown. Interleukin 7 (IL-7) is important for the maintenance of lymphocytes and can accelerate the reconstitution of effector lymphocytes in sepsis. How IL-7 influences immunosuppressive cell populations is unknown. We have used the mouse model of peritoneal contamination and infection (PCI) to investigate the expansion of immunoregulatory cells as long-term sequelae of sepsis with or without IL-7 treatment...
2018: PloS One
https://www.readbyqxmd.com/read/29465037/risk-factors-of-peritonitis-during-early-peritoneal-dialysis-in-patients-with-anca-associated-systemic-vasculitis
#3
Guangjian Liu, Jinhai Chen
This study investigated the risk factors of peritonitis during early peritoneal dialysis for renal failure in patients with antineutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis (AASV). This study enrolled hospitalized AASV patients with renal failure who underwent peritoneal dialysis at the Department of Nephrology of our hospital between 2008 and 2015. The primary aim of this study was to perform a retrospective analysis to characterize peritonitis during the early period (≤ 8 weeks) of dialysis, and to compare the differences in initial clinical manifestations, vasculitis activity, immunosuppressive therapies prior to the renal replacement therapy, and prognosis between patients with or without peritonitis...
February 21, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/29463977/a-ureteral-inguinoscrotal-hernia-from-a-pelvic-kidney
#4
Ayse V Dikmen, Cagri Guneri, Serdar Yalcin, Onur Acikgoz, Esat Ak, Sadettin Cetiner
A 74-year-old male patient with prostate cancer under remission was admitted with left inguinoscrotal swelling. He underwent scrotal ultrasound demonstrating a giant in-guinoscrotal hernia. Contrast-enhanced computerized tomography of the abdomen and pelvis demonstrated a left pelvic kidney associated with severe hydroureteronephrosis secondary to a ureteral inguinoscrotal hernia. Upon exploration with left inguinal incision, a paraperitoneal ureteral in-guinoscrotal hernia and a hypertrophic left spermatic cord were observed...
November 2017: Current Urology
https://www.readbyqxmd.com/read/29452186/lectin-obtained-from-the-red-seaweed-bryothamnion-triquetrum-secondary-structure-and-anti-inflammatory-activity-in-mice
#5
Thais Pontes Carvalho Fontenelle, Glauber Cruz Lima, Jacilane Ximenes Mesquita, José Luiz de Souza Lopes, Tarcísio Vieira de Brito, Francisco das Chagas Vieira Júnior, Adriano Bezerra Sales, Karoline Saboia Aragão, Marcellus Henrique Loiola Ponte Souza, André Luiz Dos Reis Barbosa, Ana Lúcia Ponte Freitas
Seaweeds are sources of biomolecules with biological activities and pharmacological potential - for example, lectins, a group of proteins that can bind reversibly to carbohydrates or compounds containing them. The aim of this study was to elucidate the structural properties of a lectin extracted from the red seaweed Bryothamnion triquetrum (BtL) and to investigate its anti-inflammatory activity in mice. The lectin was purified by precipitation with ammonium sulfate and ion-exchange chromatography. Its secondary structure and tryptophan (Trp) microenvironment were analyzed by circular dichroism spectroscopy and steady-state fluorescence spectroscopy, respectively...
February 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29437143/outcomes-of-acinetobacter-peritonitis-in-peritoneal-dialysis-patients-a-multicenter-registry-analysis
#6
Htay Htay, Yeoungjee Cho, Elaine M Pascoe, Carmel M Hawley, Philip A Clayton, Monique Borlace, Sunil V Badve, Kamal Sud, Neil C Boudville, Stephen P McDonald, David W Johnson
BACKGROUND: Acinetobacter is a rare but important cause of peritonitis in peritoneal dialysis (PD) patients. As the complication has not been comprehensively evaluated previously, the present study examined the outcomes of Acinetobacter peritonitis in a large, national cohort of PD patients. METHODS: The study included all episodes of peritonitis in Australia from January 2004 to December 2014 using Australia and New Zealand Dialysis and Transplant Registry (ANZDATA) data...
February 7, 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29437140/survival-analysis-and-associated-factors-in-thai-patients-on-peritoneal-dialysis-under-the-pd-first-policy
#7
Siribha Changsirikulchai, Suwannee Sriprach, Nintita S Thokanit, Jirayut Janma, Piyatida Chuengsaman, Dhavee Sirivongs
BACKGROUND: The peritoneal dialysis First (PD First) policy means that PD is the first modality of dialysis chosen for patients with end-stage renal disease (ESRD), as put forth by the Universal Health Coverage (UHC) scheme. It was initiated in Thailand in 2008. Our aim is to analyze patient survival, technique survival, and associated factors. METHODS: Data of PD patients from January 2008 to November 2016 were studied. We calculated patient and technique survival rates (censored for death and kidney transplantation)...
February 7, 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29431339/validation-of-diagnostic-methods-for-peritoneal-carcinomatosis-secondary-to-ovarian-cancer-ct-scan-pet-ct-or-laparoscopy-what-is-the-best
#8
Israel Manzanedo, Beatriz Losada, Beatriz Martínez-Torres, Fernando Pereira, Ángel Serrano, Ignacio Juez, Estíbalitz Pérez-Viejo, David Gutiérrez, Virginia Peiró, Carolina Aulló
No abstract text is available yet for this article.
February 9, 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/29424243/forward-i-a-phase-iii-study-of-mirvetuximab-soravtansine-versus-chemotherapy-in-platinum-resistant-ovarian-cancer
#9
Kathleen N Moore, Ignace Vergote, Ana Oaknin, Nicoletta Colombo, Susana Banerjee, Amit Oza, Patricia Pautier, Karim Malek, Michael J Birrer
Mirvetuximab soravtansine, an antibody-drug conjugate that binds with high affinity to folate receptor-α to provide tumor-directed delivery of the potent microtubule-disrupting agent DM4, has emerged as a promising investigational agent for the treatment of ovarian cancer, particularly in the setting of platinum-resistant disease. Here we describe the rationale and design of FORWARD I (NCT02631876), the first randomized, multicenter Phase III study to compare the safety and efficacy of mirvetuximab soravtansine versus investigator's choice of chemotherapy in women with folate receptor-α-positive, platinum-resistant epithelial ovarian, primary peritoneal or fallopian tube cancer...
February 9, 2018: Future Oncology
https://www.readbyqxmd.com/read/29419955/-predictive-factors-of-gangrenous-post-appendectomy-intra-abdominal-abscess-a-case-control-study
#10
J Serradilla, A Bueno, C De la Torre, E Domínguez, A Sánchez, B Nava, M Álvarez, M López Santamaría, L Martínez
BACKGROUND: Acute appendicitis is the most frequent surgical urgency in children. Frequently, it can be complicated with an intraabdominal abscess that will require a longer and expensive treatment. Our aim is to know if it is possible to predict this complication before its beginning. MATERIAL AND METHODS: Retrospective case-control study with patients treated between 2011 and 2016, paired according to their own characteristics (age, sex and weight), clinical aspects (symptoms, time of their onset, physical examination) and type of appendicitis (gangrenous)...
February 1, 2018: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/29413964/in-situ-generation-metabolism-and-immunomodulatory-signaling-actions-of-nitro-conjugated-linoleic-acid-in-a-murine-model-of-inflammation
#11
Luis Villacorta, Lucia Minarrieta, Sonia R Salvatore, Nicholas K Khoo, Oren Rom, Zhen Gao, Rebecca C Berman, Soma Jobbagy, Lihua Li, Steven R Woodcock, Y Eugene Chen, Bruce A Freeman, Ana M Ferreira, Francisco J Schopfer, Dario A Vitturi
Conjugated linoleic acid (CLA) is a prime substrate for intra-gastric nitration giving rise to the formation of nitro-conjugated linoleic acid (NO2-CLA). Herein, NO2-CLA generation is demonstrated within the context of acute inflammatory responses both in vitro and in vivo. Macrophage activation resulted in dose- and time-dependent CLA nitration and also in the production of secondary electrophilic and non-electrophilic derivatives. Both exogenous NO2-CLA as well as that generated in situ, attenuated NF-κB-dependent gene expression, decreased pro-inflammatory cytokine production and up-regulated Nrf2-regulated proteins...
January 12, 2018: Redox Biology
https://www.readbyqxmd.com/read/29402685/is-computed-tomography-tractography-reliable-in-patients-with-anterior-abdominal-stab-wounds
#12
İnanc Samil Sarici, Mustafa Uygar Kalayci
INTRODUCTION: The current literature and guidelines recommend that determination of peritoneal violation is done first in cases of anterior abdominal stab wounds. The primary endpoint of this study was to determine the reliability of computed tomographic (CT) tractography to assess peritoneal violation in anterior abdominal stab wounds. The secondary endpoint is to compare local wound exploration between conventional CT and CT tractography in the evaluation of peritoneal violation. MATERIAL AND METHODS: A total of 252 patients who were referred with anterior abdominal stab wounds were included in this prospective observational study...
February 2, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29394977/bladder-distension-as-a-cause-of-abdominal-compartment-syndrome
#13
Muhammad Yasir, Muhammad Qamarul Hoda, Tauseef Ahmed
Abdominal compartment syndrome (ACS) is increasingly identified in critically ill patient and its harmful effects are well documented. The disparity among the pressure, volume in abdominal cavity and its contents, results in ACS. The actual incidence of ACS is not known. However, it has been observed predominantly in patients with severe blunt and penetrating abdominal trauma, ruptured abdominal aortic aneurysms, retro- and intra-peritoneal hemorrhage, pneumoperitoneum, neoplasm, pancreatitis, ascites and multiple bone fracture...
February 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29393132/emergent-start-peritoneal-dialysis-for-end-stage-renal-disease-outcomes-and-advantages
#14
K Shivanand Nayak, Sreepada V Subhramanyam, Navva Pavankumar, Sinoj Antony, M A Sarfaraz Khan
BACKGROUND/AIMS: Initiating renal replacement therapy in late referred patients with central venous catheter (CVC) hemodialysis (HD) causes serious complications. In urgent start peritoneal dialysis, initiating peritoneal dialysis (PD) within 14 days of catheter insertion still needs HD with CVC. We initiated Emergent start PD (ESPD) with Automated PD (APD) at our center within 48 h from the time of presentation. METHODS: A prospective, case-controlled, intention-to-treat study with 56 patients was conducted between March 2016 and August 2017...
January 30, 2018: Blood Purification
https://www.readbyqxmd.com/read/29390906/comparison-of-the-symptoms-and-localisation-of-endometriosis-involvement-according-to-fertility-status-of-endometriosis-patients
#15
Fatemeh Aliani, Mahnaz Ashrafi, Arezoo Arabipoor, Ensieh Shahrokh-Tehraninejad, Shahideh Jahanian Sadatmahalleh, Mohammad Reza Akhond
This cross-sectional study aimed to assess the prevalence of endometriosis in women who were referred for Diagnostic Laparoscopy Unit due to infertility or pelvic pain between January 2012 and January 2013 and compare the symptoms and laparoscopic signs among the three groups according to the fertility status. Four hundred and thirteen women were evaluated; of these, 383 patients for infertility and 30 patients for pelvic pain and/or cyst. Endometriosis symptoms were compared between fertile and infertile women with primary and secondary infertility...
February 1, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29390363/ruptured-secondary-abdominal-pregnancy-after-primary-laparoscopic-treatment-for-tubal-pregnancy-a-case-report
#16
Duoduo Zhang, Anxia Chen, Yu Gu
INTRODUCTION: Most secondary abdominal pregnancies happen after spontaneous abortion of tubal pregnancy or ruptured intrauterine pregnancy. However, we presented a case of ruptured secondary abdominal pregnancy after primary laparoscopic treatment of tubal pregnancy. CASE REPORT: The ectopic pregnant lesion in the affected tube was thoroughly removed in the primary laparoscopy, and nothing abnormal was detected in abdomen or pelvis. Beta human chorionic gonadotropin levels dropped significantly after surgery, but the patient came back again for severe abdominal pain with beta human chorionic gonadotropin increasing, and free peritoneal fluid in the pouch of Douglas was detected at ultrasonography...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29379247/radiofrequency-ablation-of-surface-v-s-intraparenchymal-hepatocellular-carcinoma-in-cirrhotic-patients
#17
Yashwant Patidar, Praveen Singhal, Shailesh Gupta, Amar Mukund, Shiv K Sarin
Objective: To retrospectively evaluate the safety and technical efficacy of percutaneous radiofrequency ablation (RFA) of surface hepatocellular carcinoma (HCC) in comparison to intraparenchymal HCC in cirrhotic patients. Materials and Methods: Surface lesions were defined as tumours located or reaching within 1cm of liver capsule including exophytic lesions. Seventy-four surface HCC including 21 exophytic in 58 patients (surface group) and 60 intraparenchymal HCC in 54 patients (intraparenchymal group) measuring up to 4 cm in maximum extent underwent percutaneous [ultrasound (US) or computed tomography-guided (CT-guided)] RFA...
October 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29366313/laparoscopic-repair-of-perforated-peptic-ulcer-review
#18
Varcus Flore, Paun Ion, Duta Ciprian, Dobrescu Amadeus, Frandes Mirela, Tarta Cristi
BACKGROUND: Perforations of the peptic ulcers are the most common cause of emergency surgery among the complications of the gastroduodenal ulcers and the leading cause for morbidity and mortality due to secondary peritonitis and sepsis. PPU is a condition in which laparoscopic perforation repair (LPR) is an optimal solution. It makes possible the identification of the perforation's site and allows closure of the perforation and the subsequent peritoneal lavage, as in an open repair (OR) but without the large upper mid-abdominal incision...
January 23, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29364005/purulent-myositis-of-the-thigh-as-a-presentation-of-perforated-low-rectal-cancer
#19
V Jenkins, J Steinke, N Rajendran, D Kumar
Purulent myositis is an acute, intramuscular bacterial infection involving abscess formation most commonly affecting the quadriceps, hamstring and gluteal muscles. We present a case of extensive purulent myositis of the thigh and lower leg caused by bowel perforation below the peritoneal reflection secondary to rectal cancer. Cases of lower limb and perineal purulent myositis should raise suspicion of rectal perforation and should prompt investigations to exclude rectal malignancy.
January 24, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29361435/safety-and-effectiveness-of-sgm-101-a-fluorescent-antibody-targeting-carcinoembryonic-antigen-for-intraoperative-detection-of-colorectal-cancer-a-dose-escalation-pilot-study
#20
Leonora S F Boogerd, Charlotte E S Hoogstins, Dennis P Schaap, Miranda Kusters, Henricus J M Handgraaf, Maxime J M van der Valk, Denise E Hilling, Fabian A Holman, Koen C M J Peeters, J Sven D Mieog, Cornelis J H van de Velde, Arantza Farina-Sarasqueta, Ineke van Lijnschoten, Bérénice Framery, André Pèlegrin, Marian Gutowski, Simon W Nienhuijs, Ignace H J T de Hingh, Grard A P Nieuwenhuijzen, Harm J T Rutten, Francoise Cailler, Jacobus Burggraaf, Alexander L Vahrmeijer
BACKGROUND: Tumour-targeted fluorescence imaging has the potential to advance current practice of oncological surgery by selectively highlighting malignant tissue during surgery. Carcinoembryonic antigen (CEA) is overexpressed in 90% of colorectal cancers and is a promising target for colorectal cancer imaging. We aimed to assess the tolerability of SGM-101, a fluorescent anti-CEA monoclonal antibody, and to investigate the feasibility to detect colorectal cancer with intraoperative fluorescence imaging...
January 17, 2018: Lancet. Gastroenterology & Hepatology
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