keyword
https://read.qxmd.com/read/38531037/daptomycin-induced-eosinophilic-pneumonia
#1
JOURNAL ARTICLE
Michael R Hassett
Daptomycin-induced eosinophilic pneumonia (DIEP) is a rare complication of daptomycin use. Manifestations most commonly include fever, hypoxia, dyspnea, cough, eosinophilia, and lung changes on radiographs and CT. Patients typically have had recent daptomycin exposure and develop fever, dyspnea, infiltrates on chest radiograph, more than 25% eosinophils on bronchoalveolar lavage, and improvement of symptoms after withdrawal of daptomycin. Treatment includes discontinuation of daptomycin, corticosteroids, and supportive measures such as supplemental oxygen...
April 1, 2024: JAAPA: Official Journal of the American Academy of Physician Assistants
https://read.qxmd.com/read/38529671/pleural-fluid-characteristics-of-patients-with-covid-19-infection
#2
JOURNAL ARTICLE
Ryan A Denu, Victoria Forth, Majid Shafiq
INTRODUCTION: Pleural effusions are known to occur in many cases of COVID-19. Data on typical characteristics of COVID-19-associated pleural effusions are limited. The goal of this project was to characterize the pleural fluid from patients with COVID-19. METHODS: We retrospectively collected electronic medical record data from adults hospitalized at a large metropolitan hospital system with COVID-19 infection who had a pleural effusion and a thoracentesis performed...
March 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38515709/anaphylactic-deaths-a-retrospective-study-of-forensic-autopsy-cases-from-2009-to-2019-in-shanghai-china
#3
JOURNAL ARTICLE
Wen-Xin Li, Cheng-Hui Sun, Zheng-Dong Li, Jun-Yi Lin, Yu Shao, Long Chen, Li-Liang Li, Xing Ye, Yi-Wen Shen
Anaphylaxis is a rare but well-known cause of sudden unexpected death, although data from forensic autopsies in anaphylactic deaths are limited. Herein, a retrospective study of a series of allergic deaths from 2009 through 2019 in Shanghai, China, was conducted to investigate the demographic, medical, and forensic pathological characteristics of fatal anaphylaxis to improve medicolegal understanding on anaphylactic death. Sixty-two autopsy cases of anaphylactic death were registered in this study. Males dominated the cases (74...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38478043/bacterial-antigens-and-asthma-a-comparative-study-of-common-respiratory-pathogenic-bacteria
#4
JOURNAL ARTICLE
Jie Pang, Yifan Shi, Dan Peng, Lele Cui, Yingjie Xu, Wenjing Wang, Yue Hu, Yiran Yang, Jingjing Wang, Xiaofeng Qin, Yue Zhang, Hao Meng, Dan Wang, Ge Bai, Huihui Yuan, Jie Liu, Zhe Lv, Yan Li, Ye Cui, Wenjun Wang, Kewu Huang, Chris J Corrigan, Wei Wang, Yan Chen, Sun Ying
In a previous study we have shown that, in the presence of interleukin (IL)-33, repeated, per-nasal challenge of murine airways with Streptococcus pneumoniae ( S. pneumoniae ) organisms induces human asthma-like airways inflammation. It is not clear, however, whether this effect is unique or manifest in response to other common respiratory pathogens. To explore this, airways of BALB/c mice were repeatedly challenged per-nasally with formaldehyde-inactivated bacterial bodies in the presence or absence of murine recombinant IL-33...
March 13, 2024: Journal of Asthma
https://read.qxmd.com/read/38465762/hypereosinophilic-syndrome-associated-with-multiple-thromboses-requiring-icu-admission-a-case-report
#5
JOURNAL ARTICLE
Islem Ouanes, Sarra Toumi, Yasser Ben Cheikh, Oussama Ben Rejeb, Nadia Mama
Hypereosinophilic syndrome (HES) is a leucoproliferative disorder, characterized by marked blood eosinophilia and organ damage due to tissue eosinophilia. Pulmonary involvement may lead to life-threatening acute respiratory failure and intensive care unit (ICU) admission. Association between eosinophilia and thromboembolism has been previously described. However, simultaneous venous and arterial thromboses are less reported. We report a case of a 25-year-old man, admitted to the ICU and developed acute respiratory failure, laboratory tests revealed hyperleukocytosis (39,700 /µL) with high eosinophil count (27393 /µl), Computed tomographic (CT) pulmonary angiography on admission showed a right pulmonary embolism and foci of splenic infarctions...
October 5, 2023: La Tunisie Médicale
https://read.qxmd.com/read/38464832/impact-of-omicron-variant-infection-on-the-liver-kidney-and-coagulation-system-in-patients-undergoing-elective-surgery-a-retrospective-case-control-study
#6
JOURNAL ARTICLE
Xiaojuan Xiong, Rui Li, Haoyu Pei, Qingxiang Mao
Purpose: We aimed to investigate the impact of Omicron variant infection on the perioperative organ function in patients undergoing elective surgery. Methods: A total of 5029 patients who underwent elective surgery between October 2022 and January 2023 at our hospital were enrolled. Among them, the patients who underwent elective surgery between October 2022 and November 2022 composed Group 1 (not infected with the Omicron variant) the control group; those who underwent elective surgery between December 2022 and January 2023 composed Group 2 (one month after Omicron variant infection) the experimental group...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38457550/a-case-of-empty-sella-syndrome-with-adrenal-insufficiency-masked-by-prednisolone-after-administration-of-immune-checkpoint-inhibitors
#7
JOURNAL ARTICLE
Yuichiro Iwamoto, Fuminori Tatsumi, Mana Ohnishi, Yukino Katakura, Tomohiko Kimura, Masashi Shimoda, Shuhei Nakanishi, Tomoatsu Mune, Hideaki Kaneto
INTRODUCTION: The use of immune checkpoint inhibitors (ICIs) is gradually increasing; ICIs produce a variety of immune-related adverse events (irAEs), especially ICI-induced hypoadrenocorticism, which can be a lethal complication if treatment is delayed. PATIENT CONCERNS: A 63-year-old man received chemotherapy with pembrolizumab for nonsmall cell lung cancer. He developed drug-induced interstitial pneumonia 366 days after receiving pembrolizumab and was treated with prednisolone...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38456027/presumptive-pulmonary-toxocariasis-in-a-patient-affected-by-acute-myeloid-leukemia-and-hodgkin-lymphoma-case-report-and-review-of-the-literature-in-immunocompromised-hosts
#8
Tommaso Lupia, Elena Crisà, Valentina Sangiorgio, Roberta Bosio, Giacomo Stroffolini, Elena Staffilano, Vanesa Gregorc, Silvia Corcione, Francesco Giuseppe De Rosa
Toxocariasis is a zoonosis transmitted by the nematode Toxocara spp. Immunocompromised hosts are more susceptible than general population to bacterial, viral, fungal and parasitic infections. In this population toxocariasis may present as exacerbation or reactivation and could have severe or atypical manifestations being a diagnostic challenge for healthcare providers. We report a case of a presumptive pulmonary toxocariasis during chemotherapy in a patient affected by acute myeloid leukaemia (AML) and Hodgkin lymphoma and we summarize current evidence of pulmonary involvement in immunocompromised population with Toxocara spp infection in a narrative review...
2024: Le Infezioni in Medicina
https://read.qxmd.com/read/38455504/relapsing-eosinophilic-pneumonia-in-a-patient-with-recurrent-breast-cancer-receiving-abemaciclib-plus-endocrine-therapy
#9
Hiroaki Ogata, Chinami Koga, Toyoshi Yanagihara, Yuki Moriuchi, Aimi Enokizu-Ogawa, Akiko Ishimatsu, Junji Otsuka, Kazuhito Taguchi, Atsushi Moriwaki, Eriko Tokunaga, Makoto Yoshida
This report presents the case of a 42-year-old Japanese woman with recurrent hormone receptor-positive breast cancer who developed eosinophilic pneumonia (EP) during treatment with abemaciclib combined with endocrine therapy. Seven years after a radical surgery and definite diagnosis of Stage I breast cancer, her cancer recurred with metastases to multiple organs. Initially treated with abemaciclib plus letrozole and goserelin for 3 months, she developed EP, which improved after the discontinuation of anti-cancer treatment and the administration of prednisolone...
March 2024: Respirology Case Reports
https://read.qxmd.com/read/38446336/association-between-increased-risk-of-pneumonia-with-ics-in-copd-a-continuous-variable-analysis-of-patient-factors-from-the-impact-study
#10
JOURNAL ARTICLE
Bhumika Aggarwal, Paul Jones, Alejandro Casas, Mauro Gomes, Siwasak Juthong, Diego Litewka, Bernice Ong-Dela Cruz, Alejandra Ramirez-Venegas, Abdullah Sayiner, James van Hasselt, Chris Compton, Lee Tombs, Stephen Weng, Gur Levy
INTRODUCTION: Despite the proven benefits of inhaled corticosteroid (ICS)-containing triple therapy for chronic obstructive pulmonary disease (COPD), clinicians limit patient exposure to ICS due to the risk of pneumonia. However, there are multiple factors associated with the risk of pneumonia in patients with COPD. This post hoc analysis of IMPACT trial data aims to set the risks associated with ICS into a context of specific patient-related factors that contribute to the risk of pneumonia...
March 6, 2024: Pulmonary Therapy
https://read.qxmd.com/read/38444994/methylphenidate-causes-chronic-eosinophilic-pneumonia
#11
Dhafer Alghamdi, Hamdan Jahdali, Abdullah Alharbi, Ahmad Alshehri, Bandar Alfirm, Hanaa Bamefleh
A man who is 38 years old and diagnosed with attention-deficit hyperactivity disorder was prescribed methylphenidate. Three weeks later, he began experiencing progressive shortness of breath and coughing. Imaging of his chest showed patchy bilateral ground-glass opacities, and bronchoscopy revealed a 15% eosinophil count in his bronchoalveolar lavage. A transbronchial biopsy confirmed a diagnosis of eosinophilic pneumonia. The patient's condition improved when he was given steroids and stopped taking methylphenidate...
2024: Annals of Thoracic Medicine
https://read.qxmd.com/read/38414718/platelet-to-lymphocyte-ratio-plr-neutrophil-to-lymphocyte-ratio-nlr-monocyte-to-lymphocyte-ratio-mlr-and-eosinophil-to-lymphocyte-ratio-elr-as-biomarkers-in-patients-with-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-aecopd
#12
JOURNAL ARTICLE
Qian-Qian Liao, Yan-Ju Mo, Ke-Wei Zhu, Feng Gao, Bin Huang, Peng Chen, Feng-Tian Jing, Xuan Jiang, Hong-Zhen Xu, Yan-Feng Tang, Li-Wei Chu, Hai-Ling Huang, Wen-Li Wang, Fang-Ning Wei, Dan-Dan Huang, Bin-Jing Zhao, Jia Chen, Hao Zhang
PURPOSE: The study comprehensively evaluated the prognostic roles of the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), basophil-to-lymphocyte ratio (BLR), and eosinophil-to-lymphocyte ratio (ELR) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). PATIENTS AND METHODS: Six hundred and nineteen patients with AECOPD and 300 healthy volunteers were retrospectively included into the study...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38398122/machine-learning-based-classification-model-to-address-diagnostic-challenges-in-transbronchial-lung-biopsy
#13
JOURNAL ARTICLE
Hisao Sano, Ethan N Okoshi, Yuri Tachibana, Tomonori Tanaka, Kris Lami, Wataru Uegami, Yoshio Ohta, Luka Brcic, Andrey Bychkov, Junya Fukuoka
BACKGROUND: When obtaining specimens from pulmonary nodules in TBLB, distinguishing between benign samples and mis-sampling from a tumor presents a challenge. Our objective is to develop a machine-learning-based classifier for TBLB specimens. METHODS: Three pathologists assessed six pathological findings, including interface bronchitis/bronchiolitis (IB/B), plasma cell infiltration (PLC), eosinophil infiltration (Eo), lymphoid aggregation (Ly), fibroelastosis (FE), and organizing pneumonia (OP), as potential histologic markers to distinguish between benign and malignant conditions...
February 9, 2024: Cancers
https://read.qxmd.com/read/38397432/inhaled-corticosteroids-in-subjects-with-chronic-obstructive-pulmonary-disease-an-old-unfinished-history
#14
REVIEW
Andrea S Melani, Sara Croce, Gaia Fabbri, Maddalena Messina, Elena Bargagli
Chronic obstructive pulmonary disease (COPD) is one of the major causes of disability and death. Maintenance use of inhaled bronchodilator(s) is the cornerstone of COPD pharmacological therapy, but inhaled corticosteroids (ICSs) are also commonly used. This narrative paper reviews the role of ICSs as maintenance treatment in combination with bronchodilators, usually in a single inhaler, in stable COPD subjects. The guidelines strongly recommend the addition of an ICS in COPD subjects with a history of concomitant asthma or as a step-up on the top of dual bronchodilators in the presence of hospitalization for exacerbation or at least two moderate exacerbations per year plus high blood eosinophil counts (≥300/mcl)...
February 6, 2024: Biomolecules
https://read.qxmd.com/read/38395471/critical-deterioration-of-chronic-eosinophilic-pneumonia-during-pregnancy
#15
JOURNAL ARTICLE
Jake Vernon-Elliot, Jyotika Devi Prasad, Asha Bonney
Chronic eosinophilic pneumonia (CEP) is a rare, idiopathic interstitial lung disease characterised by the accumulation of eosinophils in the pulmonary interstitia and alveoli. Patients with CEP respond well to systemic corticosteroid therapy and infrequently progress to end-stage lung disease. We report a case of a woman in her 40s with previously stable, steroid-responsive CEP who experienced a critical deterioration of her CEP at 25 weeks of gestation during her third pregnancy. The patient was admitted to the intensive care unit due to respiratory failure requiring intubation and mechanical ventilation...
February 23, 2024: BMJ Case Reports
https://read.qxmd.com/read/38369876/inhaled-corticosteroids-may-not-affect-the-clinical-outcomes-of-pneumonia-in-patients-with-chronic-obstructive-pulmonary-disease
#16
JOURNAL ARTICLE
Min-Seok Chang, In-So Cho, Iseul Yu, Sunmin Park, Seok Jeong Lee, Suk Joong Yong, Won-Yeon Lee, Sang-Ha Kim, Ji-Ho Lee
BACKGROUND: Although inhaled corticosteroids (ICS) is reportedly associated with a higher risk of pneumonia in chronic obstructive pulmonary disease (COPD), the clinical implications of ICS have not been sufficiently verified to determine their effect on the prognosis of pneumonia. METHODS: The electronic health records of patients hospitalized for pneumonia with underlying COPD were retrospectively reviewed. Pneumonia was confirmed using chest radiography or computed tomography...
February 19, 2024: Tuberculosis and Respiratory Diseases
https://read.qxmd.com/read/38348233/emr-combined-with-crb-65-superior-to-curb-65-in-predicting-mortality-in-patients-with-community-acquired-pneumonia
#17
JOURNAL ARTICLE
Yi Sun, Hong Wang, Minghao Gu, Xingyu Zhang, Xiudi Han, Xuedong Liu
BACKGROUND: Data about eosinophil-to-lymphocyte ratio (ELR) and eosinophil-to-monocyte ratio (EMR) in patients with community-acquired pneumonia (CAP) are rare. We aimed to evaluate the role of EMR and ELR in predicting disease severity and mortality in patients with CAP. METHODS: A total of 454 patients (76 with severe CAP (SCAP), 378 with non-SCAP) were enrolled from November 18, 2020, and November 21, 2021. Laboratory examination on day 1 after admission was measured...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38344608/a-case-of-acute-eosinophilic-pneumonia-associated-with-non-steroidal-anti-inflammatory-drugs
#18
Rui Ribeiro, Andreia Teixeira, Tânia Lopes, Célia Cruz
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used and their gastric, cardiovascular, and renal adverse effects have been well documented. Although rare, NSAID-induced acute eosinophilic pneumonia (AEP) may occur. We report a case of AEP related to naproxen and celecoxib. The patient presented with dry cough and breathlessness two weeks after she started taking these drugs. The chest radiograph displayed bilateral opacities and she had peripheral eosinophilia. Bronchoalveolar lavage was performed at a time when blood eosinophilia was already decreasing and cell analysis revealed 63700 cells/mL with 9% eosinophil...
January 2024: Curēus
https://read.qxmd.com/read/38331769/monoclonal-antibodies-in-idiopathic-chronic-eosinophilic-pneumonia-a-scoping-review
#19
JOURNAL ARTICLE
Andrea Dionelly Murillo, Ana Isabel Castrillon, Carlos Daniel Serrano, Liliana Fernandez-Trujillo
BACKGROUND: Idiopathic chronic eosinophilic pneumonia (ICEP) is a rare disease characterized by pulmonary radiological alterations, peripheral eosinophilia, and demonstrated pulmonary eosinophilia. Oral steroids (OSs) are the standard management, but relapses occur in up to 50% of patients during the decrease or suspension of steroids, usually requiring reinitiation of treatment, exposing patients to secondary events derived from the management. Management with monoclonal antibodies has been proposed in these cases to control the disease and limit the secondary effects...
February 8, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38328630/bird-related-non-fibrotic-hypersensitivity-pneumonitis-with-bronchoalveolar-lavage-fluid-eosinophilia-that-developed-after-covid-19-vaccination-a-case-report
#20
Takuma Katano, Tomoyuki Ogisu, Akira Satou, Toshiyuki Yonezawa, Hiroyuki Tanaka, Satoru Ito
A 60-year-old man who had been keeping seven budgerigars and four cockatiels in his house for 2 years developed dyspnea and was admitted to our hospital the day after receiving the second dose of the messenger RNA coronavirus disease 2019 vaccination. Chest high resolution computed tomography (HRCT) showed bilateral ground glass opacities without nodules or mosaic attenuation. IgG specific for budgerigars was positive. Although his respiratory symptoms were resolved without corticosteroid therapy, he developed severe dyspnea soon after the discharge to his home...
February 2024: Respirology Case Reports
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