Jie Pang, Yifan Shi, Dan Peng, Lele Cui, Yingjie Xu, Wenjing Wang, Yue Hu, Yiran Yang, Jingjing Wang, Xiaofeng Qin, Yue Zhang, Hao Meng, Dan Wang, Ge Bai, Huihui Yuan, Jie Liu, Zhe Lv, Yan Li, Ye Cui, Wenjun Wang, Kewu Huang, Chris J Corrigan, Wei Wang, Yan Chen, Sun Ying
In a previous study we have shown that, in the presence of interleukin (IL)-33, repeated, per-nasal challenge of murine airways with Streptococcus pneumoniae ( S. pneumoniae ) organisms induces human asthma-like airways inflammation. It is not clear, however, whether this effect is unique or manifest in response to other common respiratory pathogens. To explore this, airways of BALB/c mice were repeatedly challenged per-nasally with formaldehyde-inactivated bacterial bodies in the presence or absence of murine recombinant IL-33...
March 13, 2024: Journal of Asthma