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https://www.readbyqxmd.com/read/27889221/the-swedish-infant-high-grade-reflux-trial-study-presentation-and-vesicoureteral-reflux-outcome
#1
Josefin Nordenström, Gundela Holmdahl, Per Brandström, Rune Sixt, Eira Stokland, Ulla Sillén, Sofia Sjöström
INTRODUCTION: High-grade vesicoureteral reflux (VUR) in infants is associated with congenital renal abnormalities, recurrent UTI, and bladder dysfunction. Endoscopic treatment (ET) is a well-established method in children with low to moderate reflux grades, but there is a lack of randomised controlled trials regarding the use of ET versus continuous antibiotic prophylaxis in infants with high-grade VUR. OBJECTIVE: This study aimed to determine whether high-grade VUR in infants can be treated with endoscopic injection and whether ET is superior to antibiotic prophylaxis in the treatment of VUR...
October 24, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27881403/irritable-bowel-syndrome-a-gut-microbiota-related-disorder
#2
Yogesh Bhattarai, David A Muniz Pedrogo, Purna C Kashyap
Irritable bowel syndrome (IBS) is one of the most common gastrointestinal (GI) disorders. Despite its prevalence, the pathophysiology of IBS is not well understood though multiple peripheral and central factors are implicated. Recent studies suggest a role for alterations in gut microbiota in IBS. Significant advances in next-generation sequencing technology and bioinformatics, and the declining cost has now allowed us to better investigate the role of gut microbiota in IBS. In the following review, we propose gut microbiota as a unifying factor in the pathophysiology of IBS...
November 23, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27868328/long-term-outcome-of-the-adjustable-transobturator-male-system-atoms-results-of-a-european-multicentre-study
#3
Alexander Friedl, Sandra Mühlstädt, Roman Zachoval, Alessandro Giammò, Danijel Kivaranovic, Maximilian Rom, Paolo Fornara, Clemens Brössner
OBJECTIVE: To evaluate the long-term effectiveness and safety of the adjustable transobturator male system (ATOMS(®) , Agency for Medical Innovations A.M.I., Feldkirch, Austria) in a European-wide multicentre setting. PATIENTS AND METHODS: In all, 287 men with stress urinary incontinence (SUI) were treated with the ATOMS device between June 2009 and March 2016. Continence parameters (daily pad test/pad use), urodynamics (maximum urinary flow rate, voiding volume, residual urine), and pain/quality of life (QoL) ratings (visual analogue scale/Leeds Assessment of Neuropathic Symptoms and Signs, International Consultation on Incontinence Questionnaire-Short Form [ICIQ-SF]/Patient Global Impression of Improvement [PGI-I]) were compared preoperatively and after intermediate (12 months) as well as after individual maximum follow-up...
November 21, 2016: BJU International
https://www.readbyqxmd.com/read/27862250/prenatal-myelomeningocele-repair-do-bladders-better
#4
Maya Horst, Luca Mazzone, Thomas Schraner, Christine Bodmer, Ueli Möhrlen, Martin Meuli, Rita Gobet
AIMS: Prenatal myelomeningocele (MMC) repair has been proven to significantly reduce the need for hydrocephalus shunting and improve lower-extremity motor outcomes. The aim of this study was to evaluate the effect of prenatal MMC repair on the urological outcome. METHODS: All patients who underwent fetal MMC repair at our institution are followed prospectively. Assessments include medical history, renal and bladder ultrasound, voiding cystourethrogram and urodynamic study, need for clean intermittent catheterization (CIC) and anticholinergics, and the occurrence of urinary tract infections (UTI)...
November 15, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27858974/report-and-research-agenda-of-the-american-geriatrics-society-and-national-institute-on-aging-bedside-to-bench-conference-on-sleep-circadian-rhythms-and-aging-new-avenues-for-improving-brain-health-physical-health-and-functioning
#5
Constance H Fung, Michael V Vitiello, Cathy A Alessi, George A Kuchel
The American Geriatrics Society, with support from the National Institute on Aging and other funders, held its eighth Bedside-to-Bench research conference, entitled "Sleep, Circadian Rhythms, and Aging: New Avenues for Improving Brain Health, Physical Health and Functioning," October 4 to 6, 2015, in Bethesda, Maryland. Part of a conference series addressing three common geriatric syndromes-delirium, sleep and circadian rhythm (SCR) disturbance, and voiding dysfunction-the series highlighted relationships and pertinent clinical and pathophysiological commonalities between these three geriatric syndromes...
November 14, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27845955/incidence-of-bladder-injury-during-retropubic-midurethral-sling-placement-after-prior-burch-colpopexy
#6
Laura Faye Gephart, Thomas J Kuehl, Michelle Reyes, Paul M Yandell, Wilma I Larsen
OBJECTIVES: To elucidate if prior Burch changes the risk of bladder injury or rates of voiding dysfunction and continence in the immediate postoperative period when undergoing retropubic midurethral sling (MUS) placement. METHODS: In this retrospective case control, charts were selected by Current Procedural Terminology codes for MUS placement. Women undergoing retropubic MUS placement with history of Burch urethropexy were considered. For every case, 2 age-matched and parity-matched controls without prior Burch were selected...
November 10, 2016: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/27842789/ketamine-a-cause-of-urinary-tract-dysfunction
#7
REVIEW
Frank Anthony Myers, Martin H Bluth, Wellman W Cheung
Drug addiction as a result of improper use of prescribed and illicit use has been on the increase globally. The effects of such use have implications in the urologic disease space. To this end, Ketamine has been reported to affect urologic function, causing a number of voiding symptoms. It may also confound the differential diagnosis of urologic diseases, such as interstitial cystitis, among others.
December 2016: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/27836867/reply-to-letter-to-the-editor-urothelial-barrier-dysfunction-cause-or-outcome-of-ketamine-induced-voiding-dysfunction
#8
Weiqun Yu
No abstract text is available yet for this article.
November 1, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27833061/long-term-functional-results-after-unilateral-mid-urethral-sling-transection-for-voiding-dysfunction
#9
F Baekelandt, P Van Oyen, C Ghysel, F Van der Aa, J Ampe
OBJECTIVE: To investigate the long-term outcomes of unilateral mid-urethral sling transection to treat voiding dysfunction after synthetic mid-urethral sling placement for stress urinary incontinence. STUDY DESIGN: Twenty-three patients who underwent an unilateral sling transection were analyzed retrospectively. Patient records were analyzed for subjective outcome, and pre- and postoperative flow patterns were used as objective outcome parameters. RESULTS: At the first postoperative follow-up, 77...
October 26, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27828991/loss-of-mecp2-causes-urological-dysfunction-and-contributes-to-death-by-kidney-failure-in-mouse-models-of-rett-syndrome
#10
Christopher S Ward, Teng-Wei Huang, José A Herrera, Rodney C Samaco, Meagan R Pitcher, Alan Herron, Steven A Skinner, Walter E Kaufmann, Daniel G Glaze, Alan K Percy, Jeffrey L Neul
Rett Syndrome (RTT) is a neurodevelopmental disorder characterized by loss of acquired skills during development, autonomic dysfunction, and an increased risk for premature lethality. Clinical experience identified a subset of individuals with RTT that present with urological dysfunction including individuals with frequent urinary tract infections, kidney stones, and urine retention requiring frequent catheterization for bladder voiding. To determine if urologic dysfunction is a feature of RTT, we queried the Rett Syndrome Natural History Study, a repository of clinical data from over 1000 individuals with RTT and found multiple instances of urological dysfunction...
2016: PloS One
https://www.readbyqxmd.com/read/27789288/bladder-overactivity-involves-overexpression-of-microrna-132-and-nerve-growth-factor
#11
Mahendra Kashyap, Subrata Pore, Michael Chancellor, Naoki Yoshimura, Pradeep Tyagi
AIM: Here, we assessed the expression of non-protein coding microRNAs (miRs), nerve growth factor and inflammatory molecules in the rat model of acetic acid induced bladder overactivity. MAIN METHODS: Under isoflurane anesthesia, adult female Sprague-Dawley rats were instilled for 30min with either saline or NGF antisense oligonucleotide complexed with liposomes. 24h later, treated rats were exposed to either intravesical infusion of saline or saline containing 0...
December 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/27781344/endoscopic-antireflux-surgery-leading-to-obstruction-in-pediatric-renal-transplant-patients
#12
Gina Cambareri, Christina Carpenter, Jeffrey Stock, Jane Lewis, Sarah Marietti
To describe a multicenter experience with management of ureteral obstruction after injection of Dx/HA for VUR in pediatric renal transplant patients. The records of all pediatric renal transplant patients who underwent Dx/HA injection for VUR and had subsequent obstruction were identified, and the management and outcomes were reviewed. Follow-up ranged from 1 to 10 years. There were four patients identified, all of whom had a history of rising creatinine, recurrent UTI, and increasing hydronephrosis which led to the diagnosis of high-grade VUR...
October 26, 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27778376/post-injury-bladder-management-strategy-influences-lower-urinary-tract-dysfunction-in-the-mouse-model-of-spinal-cord-injury
#13
Naoki Wada, Takahiro Shimizu, Shun Takai, Nobutaka Shimizu, Anthony J Kanai, Pradeep Tyagi, Hidehiro Kakizaki, Naoki Yoshimura
AIMS: To examine the effects of a different number of daily bladder squeezes on bladder dysfunction in mice with spinal cord injury (SCI). METHODS: Spinal cord was transected at the Th8/9 in female C57BL/6N mice. Their bladders were manually squeezed to eliminate urine inside every day for 4 weeks. The mice were divided into three groups depending on the number of bladder squeezes; A: once daily, B: twice daily, C: three times daily. Four weeks after transection, single-filling cystometry were performed under an awake condition...
October 24, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27752863/effects-of-daily-tadalafil-on-lower-urinary-tract-symptoms-in-young-men-with-multiple-sclerosis-and-erectile-dysfunction-a-pilot-study
#14
D Francomano, A Ilacqua, A Cortese, G Tartaglia, A Lenzi, M Inghilleri, A Aversa
PURPOSE: Men affected by multiple sclerosis often experience neurogenic overactive bladder (OAB), lower urinary tract symptoms and erectile dysfunction (ED). The aim of the study was to investigate modifications of urinary and sexual functions after administration of daily tadalafil (TAD) 5 mg. METHODS: Twenty men were enrolled in a single-blind, 4-week prospective study while 10 men without treatment served as controls. Primary outcomes were changes from baseline of International Prostate Symptom (IPSS), OAB questionnaire (OAB-q-short form) and International Index of Erectile Function (IIEF-5) scores...
October 17, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27752507/constipation-and-lower-urinary-tract-dysfunction-in-children-and-adolescents-a-population-based-study
#15
Clara Sampaio, Ariane Sampaio Sousa, Luis Gustavo A Fraga, Maria Luiza Veiga, José Murillo Bastos Netto, Ubirajara Barroso
OBJECTIVE: To evaluate the correlation between constipation and lower urinary tract dysfunction (LUTD) and nocturnal enuresis in a population-based study. MATERIAL AND METHODS: This is a cross-sectional study. The criteria for inclusion were children and adolescents of between 5 and 17 years and who agreed to sign the informed consent form. The study excluded students with neurological problems or who had documented abnormalities of the urinary tract. To identify the presence and severity of LUTD, we used the Voiding Dysfunction Symptom Score (DVSS)...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27751414/effect-of-umbilical-cord-blood-stem-cells-transplantation-on-bladder-dysfunction-induced-by-cerebral-ischemia-in-rats
#16
Ching-Chung Liang, Tsong-Hai Lee, Shuenn-Dhy Chang
OBJECTIVE: To demonstrate the effect of human umbilical cord blood-derived CD34(+) cells on bladder dysfunction induced by cerebral ischemia in rats. MATERIALS AND METHODS: Female rats were subjected to either 60 minute middle cerebral artery occlusion (MCAO) or a sham operation. Rats were divided into four groups: sham operation, MCAO without treatment, infusion with 1×10(6) CD34(+) cells 30 minutes before MCAO, and infusion with 1×10(6) CD34(+) cells 3 hours after MCAO...
October 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27750360/pharmacological-properties-of-propiverine-contribute-to-improving-lower-urinary-tract-dysfunctions-in-rats-with-spinal-cord-injuries
#17
F Sakakibara, K Takahama, M Nanri, E Sasaki
Patients with spinal cord injury (SCI) usually develop lower urinary tract dysfunctions, including detrusor overactivity which is also known to be a risk factor for upper urinary tract dysfunction. Antimuscarinic agents, such as propiverine, have been used clinically for the treatment of detrusor overactivity. Also, propiverine has been known to possess antagonistic activity against L-type Ca(2+) channels and transient receptor potential vanilloid subtype 1 (TRPV1), in addition to activity against muscarinic receptors...
September 2016: Drug Research
https://www.readbyqxmd.com/read/27746247/cowper-s-syringocele-a-rare-differential-diagnosis-of-infravesical-obstruction-in-boys-and-young-adults
#18
Felix Blasl, Wolfgang H Rösch, Mark Koen, Mircia-Aurel Ardelean, Anne-Karoline Ebert
OBJECTIVE AND INTRODUCTION: Cowper's syringocele is a cystic dilation of the bulbourethral gland duct, initially defined by Maizels et al. in 1983. Although obstructive and non-obstructive types of this rare anomaly are described, clinical symptoms are highly unspecific. Therefore, we report 12 cases of children and young adults diagnosed with Cowper's syringocele to further clarify clinical course, comorbidity and treatment strategies. STUDY DESIGN: We retrospectively collected clinical data of 12 children and young adults from birth to 18...
October 8, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27721639/role-of-urodynamics-in-stress-urinary-incontinence-a-critical-appraisal
#19
Shirish Dattatraya Yande, Omkar Vinay Joglekar, Maya Joshi
INTRODUCTION: Role of urodynamics prior to surgery of stress urinary incontinence (SUI) is under constant debate. Demonstration of the presence of detrusor overactivity is the only aspect that has been emphasized in the literature so far. We believe that there are number of other factors which may influence the evaluation and in turn the choice of surgical management and prediction of outcome of treatment. They are as follows: (1) Presence of voiding inefficiency, (2) asymptomatic detrusor overactivity, (3) and severity of SUI...
July 2016: Journal of Mid-life Health
https://www.readbyqxmd.com/read/27719863/urologic-symptoms-and-functional-neurologic-disorders
#20
I Hoeritzauer, V Phé, J N Panicker
The term functional urologic disorders covers a wide range of conditions related broadly to altered function rather than structure of the lower urinary tract, mainly of impaired urine voiding or storage. Confusingly, for a neurologic readership, these disorders of function may often be due to a urologic, gynecologic, or neurologic cause. However, there is a subset of functional urologic disorders where the cause remains uncertain and, in this chapter, we describe the clinical features of these disorders in turn: psychogenic urinary retention; Fowler's syndrome; paruresis (shy-bladder syndrome); dysfunctional voiding; idiopathic overactive bladder, and interstitial cystitis/bladder pain syndrome...
2017: Handbook of Clinical Neurology
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