Daisuke Gotoh, Kazumasa Torimoto, Kenta Onishi, Yosuke Morizawa, Shunta Hori, Yasushi Nakai, Makito Miyake, Kiyohide Fujimoto, Naoki Yoshimura
The study aimed to investigate the bladder and urethral activity, and nitric oxide-related molecular changes in aging rats. Rats were divided into two groups: Group Y (young rats; 12-weeks); and Group A (aging rats; 15-months). A 24 h voiding assay was performed, and the urodynamic parameters were evaluated using awake cystometry (CMG) and urethral perfusion pressure (UPP) recordings under urethane anesthesia. The mRNA expression levels of NO-, ischemia-, and inflammation-related markers in urethra and bladder tissues and cGMP levels in the urethra were assessed...
September 28, 2023: American Journal of Physiology. Renal Physiology