keyword
https://read.qxmd.com/read/37811396/stress-induced-symptom-exacerbation-stress-increases-voiding-frequency-somatic-sensitivity-and-urinary-bladder-ngf-and-bdnf-expression-in-mice-with-subthreshold-cyclophosphamide-cyp
#21
JOURNAL ARTICLE
Beatrice M Girard, Susan E Campbell, Margaret A Vizzard
Symptom exacerbation due to stress is prevalent in many disease states, including functional disorders of the urinary bladder (e.g., overactive bladder (OAB), interstitial cystitis/bladder pain syndrome (IC/BPS)); however, the mechanisms underlying the effects of stress on micturition reflex function are unclear. In this study we designed and evaluated a stress-induced symptom exacerbation (SISE) mouse model that demonstrates increased urinary frequency and somatic (pelvic and hindpaw) sensitivity. Cyclophosphamide (CYP) (35 mg/kg; i...
2023: Front Urol
https://read.qxmd.com/read/37767570/impaired-nitric-oxide-mechanisms-underlying-lower-urinary-tract-dysfunction-in-aging-rats
#22
JOURNAL ARTICLE
Daisuke Gotoh, Kazumasa Torimoto, Kenta Onishi, Yosuke Morizawa, Shunta Hori, Yasushi Nakai, Makito Miyake, Kiyohide Fujimoto, Naoki Yoshimura
The study aimed to investigate the bladder and urethral activity, and nitric oxide-related molecular changes in aging rats. Rats were divided into two groups: Group Y (young rats; 12-weeks); and Group A (aging rats; 15-months). A 24 h voiding assay was performed, and the urodynamic parameters were evaluated using awake cystometry (CMG) and urethral perfusion pressure (UPP) recordings under urethane anesthesia. The mRNA expression levels of NO-, ischemia-, and inflammation-related markers in urethra and bladder tissues and cGMP levels in the urethra were assessed...
September 28, 2023: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/37746884/effects-of-parental-holding-on-pain-response-in-young-children-during-cystometry-a-randomized-controlled-trial
#23
JOURNAL ARTICLE
Jieun Park, Hyejung Lee, Sang Won Han, Eun Kyoung Choi
INTRODUCTION: Cystometry is essential for evaluating bladder function. However, children may react negatively to the physical pain of urethral catheterization or anxiety and fear of an unfamiliar environment. These pain responses during the cystometry procedure may interfere with the cystometry procedure and make it difficult to interpret the cystometry result. In this regard, the International Children's Continence Society has advised performing cystometry while holding infants as an effective nonpharmacological pain management method, but there is insufficient evidence to support this...
September 25, 2023: Neurourology and Urodynamics
https://read.qxmd.com/read/37725275/vagal-afferent-responses-to-cystometry-in-rat-models-of-urinary-bladder-irritation-c-fos-immunohistochemistry-study
#24
JOURNAL ARTICLE
Ezidin G Kaddumi, AbdulFattah S Fararjeh, Manal Udwan
PURPOSE: Although recent literature provides increasing evidence concerning urinary bladder innervation by vagal afferents, the functional aspects and the conditions at which these afferents are recruited are still unclear. METHODS: In the present study, the neuronal responses of nodose ganglion following cystometry, under different models of rat's urinary bladder irritation, cyclophosphamide (CYP), cyclophosphamide with cervical vagotomy (Vx), chronic HCl, and acute HCl, were investigated using c-fos immunohistochemistry...
September 19, 2023: International Urology and Nephrology
https://read.qxmd.com/read/37692906/repeated-variate-stress-increased-voiding-frequency-and-altered-trpv1-and-trpv4-transcript-expression-in-lower-urinary-tract-lut-pathways-in-female-mice
#25
JOURNAL ARTICLE
Amanda B Sidwell, Celia McClintock, Katharine I Beča, Susan E Campbell, Beatrice M Girard, Margaret A Vizzard
Psychological stress is associated with urinary bladder dysfunction (e.g., increased voiding frequency, urgency and pelvic pain); however, the mechanisms underlying the effects of stress on urinary bladder function are unknown. Transient receptor potential (TRP) channels (vanilloid family) may be potential targets for intervention due to their distribution in the LUT and role in pain. Here, we examine a model of repeated variate stress (RVS) of 2 week (wk) or 4 wk duration in female mice and its effects on bladder function, anxiety-like behavior, and TRPV transcript expression in urinary bladder and lumbosacral spinal cord and associated dorsal root ganglia (DRG)...
2023: Front Urol
https://read.qxmd.com/read/37589552/-functional-vesico-sphincteric-disordes-in-children-clinical-urodynamic-and-evolutionary-profile
#26
JOURNAL ARTICLE
Maryem Ferjani, Yousra Hammi, Taha Sayari, Rym Baati, Naija Ouns, Tahar Gargah
BACKGROUND: Childhood vesico-sphincteric disorders are the cause of functional and psychological disability. They are also responsible for serious uronephrologic complications akin to neuro-bladder complications. In this study, we looked for the clinical manifestations linked to these disorders as well as the paraclinical and urodynamic anomalies and their therapeutic management. METHODS: We carried out a retrospective and descriptive study of patients with vesico-sphincteric disorders, followed in the pediatrics department of Charles Nicolle hospital in Tunis...
August 17, 2023: Néphrologie & Thérapeutique
https://read.qxmd.com/read/37583249/reflex-voiding-in-rat-occurs-at-consistent-bladder-volume-regardless-of-pressure-or-infusion-rate
#27
JOURNAL ARTICLE
Daniel J Jaskowak, Zachary C Danziger
AIMS: The central nervous system (CNS) regulates lower urinary tract reflexes using information from sensory afferents; however, the mechanisms of this process are not well known. Pressure and volume were measured at the onset of the guarding and micturition reflexes across a range of infusion rates to provide insight into what the CNS is gauging to activate reflexes. METHODS: Female Sprague Dawley rats were anesthetized with urethane for open outlet cystometry...
September 2023: Neurourology and Urodynamics
https://read.qxmd.com/read/37554988/ultrasound-assisted-intravesical-botulinum-toxin-a-delivery-attenuates-acetic-acid-induced-bladder-hyperactivity-in-rats
#28
JOURNAL ARTICLE
Qinggang Liu, Yi Gao, Huiling Cong, Limin Liao
Background: Intradetrusor injection of botulinum toxin A (BTX-A) is an effective treatment for overactive bladder (OAB). However, the occurrence of adverse events associated with BTX-A injection therapy hinders its acceptance among patients and its clinical promotion. Intravesical instillation of BTX-A offers a promising alternative to injection therapy for treating OAB. Nevertheless, due to the presence of the bladder permeability barrier (BPB) and the high molecular weight of BTX-A, direct instillation is unable to penetrate the bladder urothelium...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37508880/pressure-volume-loop-analysis-of-voiding-workload-an-application-in-trans-vaginal-mesh-repaired-pelvic-organ-prolapse-patients
#29
JOURNAL ARTICLE
Hui-Hsuan Lau, Cheng-Yuan Lai, Ming-Chun Hsieh, Hsien-Yu Peng, Dylan Chou, Tsung-Hsien Su, Jie-Jen Lee, Tzer-Bin Lin
Although trans-vaginal mesh (TVM) offers a successful anatomical reconstruction and can subjectively relieve symptoms/signs in pelvic organ prolapse (POP) patients, its objective benefits to the voiding function of the bladder have not been well established. In this study, we investigated the therapeutic advantage of TVM on bladder function by focusing on the thermodynamic workload of voiding. The histories of 31 POP patients who underwent TVM repair were retrospectively reviewed. Cystometry and pressure volume analysis (PVA) of the patients performed before and after the operation were analyzed...
July 19, 2023: Bioengineering
https://read.qxmd.com/read/37507456/mid-lumbar-l3-epidural-stimulation-effects-on-bladder-and-external-urethral-sphincter-in-non-injured-and-chronically-transected-urethane-anesthetized-rats
#30
JOURNAL ARTICLE
Daniel Medina-Aguiñaga, Robert F Hoey, Natasha L Wilkins, Beatrice Ugiliweneza, Jason Fell, Susan J Harkema, Charles H Hubscher
Recent pre-clinical and clinical spinal cord epidural stimulation (scES) experiments specifically targeting the thoracolumbar and lumbosacral circuitries mediating lower urinary tract (LUT) function have shown improvements in storage, detrusor pressure, and emptying. With the existence of a lumbar spinal coordinating center in rats that is involved with external urethral sphincter (EUS) functionality during micturition, the mid-lumbar spinal cord (specifically L3) was targeted in the current study with scES to determine if the EUS and thus the void pattern could be modulated, using both intact and chronic complete spinal cord injured female rats under urethane anesthesia...
July 28, 2023: Scientific Reports
https://read.qxmd.com/read/37492642/transdermal-tibial-nerve-optogenetic-stimulation-targeting-c-fibers
#31
JOURNAL ARTICLE
Zhonghan Zhou, Xuesheng Wang, Xunhua Li, Limin Liao
Purpose: To explore whether stimulation of C-fibers in tibial nerves can induce bladder inhibition by optogenetic transdermal illumination. Methods: Ten rats were injected with AAV2/6-hSyn-ChR2(H134R)-EYFP into the tibial nerves. Transurethral cystometry was performed 4 weeks after the virus injection. Illumination (473-nm blue light at 100 mW) was performed with the fiber positioned above the right hind paw near the ankle. The light transmission efficiency was examined with a laser power meter. The effects on cystometry were compared before and after illumination with the bladder infused with normal saline and acetic acid, respectively...
2023: Frontiers in Physiology
https://read.qxmd.com/read/37463319/hypoxanthine-induces-signs-of-bladder-aging-with-voiding-dysfunction-and-lower-urinary-tract-remodeling
#32
JOURNAL ARTICLE
Lori A Birder, Amanda S Wolf-Johnston, Irina Zabbarova, Youko Ikeda, Anne M Robertson, Ricardo Cardozo, Fatemeh Azari, Anthony J Kanai, George A Kuchel, Edwin K Jackson
BACKGROUND: Lower urinary tract syndrome (LUTS) is a group of urinary tract symptoms and signs which can include urinary incontinence. Advancing age is a major risk factors for LUTS; however the underlying biochemical mechanisms of age-related LUTS remain unknown. HX (hypoxanthine) is a purine metabolite associated with generation of tissue damaging reactive oxygen species (ROS). This study tested the hypothesis that exposure of the adult bladder to HX-ROS over time damages key LUT elements, mimicking qualitatively some of the changes observed with aging...
July 18, 2023: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/37455557/mettl3-dependent-m6a-modification-mediates-bladder-remodeling-after-partial-bladder-outlet-obstruction-through-ccn2-activation
#33
JOURNAL ARTICLE
Yafei Yang, Jun Long, Jin Yang, Hanxiong Zheng, Yongchang Lai, Chiheng Chen, Fucai Tang, Yibo Gao, Lin Chen, Zhaohui He
AIMS: N6-methyladenosine (m6A) modification is a critical posttranscriptional event in gene regulation. Thus, identifying methyltransferase, demethylase, or m6A binding protein-mediated m6A modifications in cancer or noncancer transcriptomes has become a promising novel strategy for disease therapy development. However, novel insights into m6A modification in partial bladder outlet obstruction (pBOO) and detailed information about the drivers of bladder remodeling remain to be elucidated...
July 16, 2023: Neurourology and Urodynamics
https://read.qxmd.com/read/37417411/-efficacy-of-fesoterodine-for-prevention-of-autonomic-dysreflexia-in-patients-with-neurogenic-dysfunction-of-the-bladder-after-spinal-cord-injury
#34
JOURNAL ARTICLE
R V Salyukov, A A Kamalov, D A Okhobotov, M E Chalyi, M V Frolova
AIM: to evaluate the effectiveness of fesoterodine for the prevention of autonomic dysreflexia (AD) in patients with neurogenic bladder dysfunction (NBD) after spinal cord injury (SCI). MATERIALS AND METHODS: a total of 53 patients with AD were included in the study. In the main group (n=33) patients received fesoterodine 4 mg per day for 12 weeks as a treatment for neurogenic bladder dysfunction and prevention of AD. In the control group (n=20), patients were monitored for 12 weeks without specific treatment...
July 2023: Urologii︠a︡
https://read.qxmd.com/read/37371634/assessing-neurogenic-lower-urinary-tract-dysfunction-after-spinal-cord-injury-animal-models-in-preclinical-neuro-urology-research
#35
REVIEW
Adam W Doelman, Femke Streijger, Steve J A Majerus, Margot S Damaser, Brian K Kwon
Neurogenic bladder dysfunction is a condition that affects both bladder storage and voiding function and remains one of the leading causes of morbidity after spinal cord injury (SCI). The vast majority of individuals with severe SCI develop neurogenic lower urinary tract dysfunction (NLUTD), with symptoms ranging from neurogenic detrusor overactivity, detrusor sphincter dyssynergia, or sphincter underactivity depending on the location and extent of the spinal lesion. Animal models are critical to our fundamental understanding of lower urinary tract function and its dysfunction after SCI, in addition to providing a platform for the assessment of potential therapies...
May 26, 2023: Biomedicines
https://read.qxmd.com/read/37353085/bladder-capacity-in-women-with-overactive-bladder-syndrome-a-cross-sectional-study
#36
JOURNAL ARTICLE
Luis López-Fando, Paola Calleja Hermosa, Clara Velasco Balanza, Miguel Jiménez Cidre, José Luis Gutiérrez Baños, Vanessa Viegas, Ana Sánchez Ramírez, Manuel Esteban Fuertes, Cristina Gutiérrez Ruiz, Peri Cusí Lluis, David Castro Díaz, Salvador Arlandis Guzmán
OBJECTIVE: To evaluate bladder capacity in women with idiopathic OAB through bladder diary, cystomanometry, and uroflowmetry and assess the concordance of the different measures of bladder capacity. A secondary objective is to describe the relationship between bladder capacity and urinary frequency in OAB patients. METHODS: An observational cross-sectional multicentric study was conducted, including female patients diagnosed with idiopathic OAB. All participants underwent a urodynamic study and completed a 3-day bladder diary (3dBD)...
June 21, 2023: Urology
https://read.qxmd.com/read/37318991/optogenetic-urothelial-cell-stimulation-induces-bladder-contractions-and-pelvic-nerve-afferent-firing
#37
JOURNAL ARTICLE
Gabreilla L Robilotto, Olivia J Yang, Firoj Alom, Richard D Johnson, Aaron D Mickle
Urothelial cells, which play an essential role in the barrier function, are also thought to play a sensory role in bladder physiology by releasing signaling molecules in response to sensory stimuli that act upon adjacent sensory neurons. However, it is challenging to study this communication due to the overlap in receptor expression and proximity of urothelial cells to sensory neurons. To overcome this challenge, we have developed a mouse model where we can directly stimulate urothelial cells using optogenetics...
June 15, 2023: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/37301318/possible-involvement-of-brain-hydrogen-sulphide-in-the-inhibition-of-the-rat-micturition-reflex-induced-by-activation-of-brain-alpha7-nicotinic-acetylcholine-receptors
#38
JOURNAL ARTICLE
Nobutaka Shimizu, Takahiro Shimizu, Youichirou Higashi, Suo Zou, Hideo Fukuhara, Takashi Karashima, Keiji Inoue, Motoaki Saito
We previously reported that brain α7 nicotinic acetylcholine receptors inhibited the rat micturition reflex. To elucidate the mechanisms underlying this inhibition, we focused on the relationship between α7 nicotinic acetylcholine receptors and hydrogen sulphide (H2 S) because we found that H2 S also inhibits the rat micturition reflex in the brain. Therefore, we investigated whether H2 S is involved in the inhibition of the micturition reflex induced by the activation of α7 nicotinic acetylcholine receptors in the brain...
June 8, 2023: European Journal of Pharmacology
https://read.qxmd.com/read/37293023/acute-ampakines-increase-voiding-function-and-coordination-in-a-rat-model-of-sci
#39
Sabhya Rana, Firoj Alom, Robert C Martinez, David D Fuller, Aaron D Mickle
UNLABELLED: Neurogenic bladder dysfunction causes urological complications and reduces the quality of life in persons with spinal cord injury (SCI). Glutamatergic signaling via AMPA receptors is fundamentally important to the neural circuits controlling bladder voiding. Ampakines are positive allosteric modulators of AMPA receptors that can enhance the function of glutamatergic neural circuits after SCI. We hypothesized that ampakines can acutely stimulate bladder voiding that has been impaired due to thoracic contusion SCI...
May 28, 2023: bioRxiv
https://read.qxmd.com/read/37283037/lack-of-expression-of-mir-29a-b1-impairs-bladder-function-in-male-mice
#40
JOURNAL ARTICLE
Zunyi Wang, Robert Spitz, Chad Vezina, Jianghui Hou, Dale E Bjorling
Lower urinary tract symptoms (LUTS) refer to various urological diseases, and incomplete bladder emptying is common among affected patients. The etiology of LUTS is largely unknown, and investigations of LUTS suggest that bladder fibrosis contributes to pathogenesis of LUTS. MicroRNAs (miRNAs) are short (∼22 nucleotides), non-coding RNAs that repress target gene expression by a combination of mRNA degradation and translation inhibition. The miR-29 family is best known for its anti-fibrotic role in various organs...
June 1, 2023: Disease Models & Mechanisms
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