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Alejandro Ropolo, Daniel Grasso, Romina Pardo, Maria L Sacchetti, Cendrine Archange, Andrea Lo Re, Mylene Seux, Jonathan Nowak, Claudio D Gonzalez, Juan L Iovanna, Maria I Vaccaro
Autophagy is a degradation process of cytoplasmic cellular constituents, which serves as a survival mechanism in starving cells, and it is characterized by sequestration of bulk cytoplasm and organelles in double-membrane vesicles called autophagosomes. Autophagy has been linked to a variety of pathological processes such as neurodegenerative diseases and tumorigenesis, which highlights its biological and medical importance. We have previously characterized the vacuole membrane protein 1 (VMP1) gene, which is highly activated in acute pancreatitis, a disease associated with morphological changes resembling autophagy...
December 21, 2007: Journal of Biological Chemistry
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