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https://www.readbyqxmd.com/read/28453710/prescription-of-antibiotics-to-pre-school-children-from-2005-to-2014-in-japan-a-retrospective-claims-database-study
#1
Satomi Yoshida, Masato Takeuchi, Koji Kawakami
Background: Antibiotics are the most frequently prescribed medications for children but inappropriate antibiotic prescribing is prevalent. The purpose of our study was to access the nationwide trend in antibiotic prescriptions, and to ascertain inappropriate prescribing for upper respiratory infections (URIs) in pre-school children in Japan. Methods: Data from the administrative claims database from 2005 January to 2014 September in Japan were examined. We identified outpatient antibiotic prescription claims and described prescription patterns of subjects who were followed from birth to 6 years of age...
April 27, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28447330/seawater-drowning-associated-pneumonia-a-10-year-descriptive-cohort-in-intensive-care-unit
#2
Alexandre Robert, Pierre-Éric Danin, Hervé Quintard, Nicolas Degand, Nihal Martis, Denis Doyen, Céline Pulcini, Raymond Ruimy, Carole Ichai, Gilles Bernardin, Jean Dellamonica
BACKGROUND: Pneumonia is one of the major complications of drowning, but the optimal empirical antibiotic treatment is not clearly defined. Multidrug-resistant (MDR) bacteria and fungi have been identified in a recent series of freshwater drowning-associated pneumonia. However, microbial data in seawater drowning are scarce. The objective of the study is to describe the microorganisms isolated in early respiratory specimens obtained from seawater drowning-associated pneumonia and to provide their antibiotic susceptibility pattern...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28443633/corrigendum-characterization-of-a-p1-like-bacteriophage-carrying-ctx-m-27-in-salmonella-spp-resistant-to-third-generation-cephalosporins-isolated-from-pork-in-china
#3
Ling Yang, Wan Li, Gui-Ze Jiang, Wen-Hui Zhang, Huan-Zhong Ding, Ya-Hong Liu, Zhen-Ling Zeng, Hong-Xia Jiang
No abstract text is available yet for this article.
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28443500/occurrence-of-tem-shv-and-ctx-m-%C3%AE-lactamases-in-clinical-isolates-of-proteus-species-in-a-tertiary-care-center
#4
Mohit Chaubey, Suchitra Shenoy
BACKGROUND: Extended spectrum beta lactamases (ESBL) are responsible for increased resistance to third generation cephalosporins. Proteus species is an important cause of both community acquired and nosocomial infections. The Proteus spp is usually susceptible to beta lactam drugs but there is progressive increase in beta lactam resistance and recently ESBLs are also fast spreading to this species. OBJECTIVE: This study was conducted to study ESBL production and occurrence of TEM, SHV and CTX M beta lactamases in clinical isolates of Proteus spp in a tertiary care centre...
April 25, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28438934/susceptibility-of-imipenem-susceptible-but-meropenem-resistant-enterobacteriaceae-carrying-blaimp-6-to-various-antibacterials-including-siderophore-cephalosporin-cefiderocol
#5
Sachi Kanazawa, Takafumi Sato, Naoki Kohira, Tsukasa Ito-Horiyama, Masakatsu Tsuji, Yoshinori Yamano
Carbapenemase-producing Enterobacteriaceae (CPE) have been spreading worldwide and are a great concern among healthcare settings (1).….
April 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28438590/antibiotic-prophylaxis-in-cataract-surgery-in-the-setting-of-penicillin-allergy-a-decision-making-algorithm
#6
REVIEW
Benjamin R LaHood, Nicholas Andrew, Michael Goggin
Cataract surgery is the most commonly performed surgical procedure in many developed countries. Post-operative endophthalmitis is a rare complication with potentially devastating visual outcomes. Currently, there is no global consensus regarding antibiotic prophylaxis in cataract surgery despite growing evidence of the benefits of prophylactic intracameral cefuroxime at the conclusion of surgery. The decision about which antibiotic regimen to use is further complicated in patients reporting penicillin allergy...
April 21, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28437695/fe-iii-promoted-transformation-of-%C3%AE-lactam-antibiotics-hydrolysis-vs-oxidation
#7
Jiabin Chen, Ying Wang, Yajie Qian, Tianyin Huang
The widely used β-lactam antibiotics are susceptible to oxidative and/or hydrolytic degradation promoted by some metal ions (e.g., Cu(II)). Ferric ions (Fe(III)) are among the most common metal ions, but their role in the environmental transformation and fate of β-lactam antibiotics is still unknown. This study elucidates that Fe(III) can promote degradation of β-lactam antibiotics under environmental aquatic conditions. Degradation rate constants of ampicillin (AMP) linearly increased with increasing Fe(III) concentration, but were independent of AMP concentration when AMP was higher than Fe(III) concentration...
April 6, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28435078/preformulation-studies-of-ceftriaxone-for-pediatric-non-parenteral-administration-as-an-alternative-to-existing-injectable-formulations
#8
Tina Kauss, Mathieu Marchivie, Thida Phoeung, Alexandra Gaubert, Amélie Désiré, Giovanni Tonelli, Chantal Boyer, Marie-Hélène Langlois, Anthony Cartwright, Melba Gomes, Nicholas White, Karen Gaudin
Ceftriaxone, a third generation cephalosporin, has a wide antibacterial spectrum that has good CNS penetration, which makes it potentially suitable for initial treatment of severe neonatal pediatric infections providing suitable formulation. We evaluated its physicochemical and technical characteristics to assess its potential for development as a non-parenteral dosage form. As ceftriaxone is marked only for injectable use, these data are not available. Using HPLC and Karl Fischer titration, sensitivity of ceftriaxone to water, feasibility and impact of pharmaceutical processes and compatibility with common pharmaceutical excipients were assessed...
April 20, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28435019/epidemiology-and-trends-in-the-antibiotic-susceptibilities-of-gram-negative-bacilli-isolated-from-patients-with-intra-abdominal-infections-in-the-asia-pacific-region-2010-2013
#9
Ya-Ting Chang, Geoffrey Coombs, Thomas Ling, V Balaji, Camilla Rodrigues, Hiroshige Mikamo, Min-Ja Kim, Datin Ganeswrie Rajasekaram, Myrna Mendoza, Thean Yen Tan, Pattarachai Kiratisin, Yuxing Ni, Weinman Barry, Yingchun Xu, Yen-Hsu Chen, Po-Ren Hsueh
This study was conducted to investigate the epidemiology and antimicrobial susceptibility patterns of Gram-negative bacilli (GNB) isolated from intra-abdominal infections (IAIs) in the Asia-Pacific region (APR) from 2010-2013. A total of 17 350 isolates were collected from 54 centres in 13 countries in the APR. The three most commonly isolated GNB were Escherichia coli (46.1%), Klebsiella pneumoniae (19.3%) and Pseudomonas aeruginosa (9.8%). Overall, the rates of extended-spectrum β-lactamase (ESBL)-producing E...
April 20, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28434898/bacteraemia-due-to-ampc-%C3%AE-lactamase-producing-escherichia-coli-in-hospitalized-cancer-patients-risk-factors-antibiotic-therapy-and-outcomes
#10
Qing Zhang, Wenfang Zhang, Zheng Li, Changsen Bai, Ding Li, Shan Zheng, Peng Zhang, Sihe Zhang
AmpC β-lactamase-producing Escherichia coli (AmpC-EC) is one of the main antimicrobial resistant pathogens in patients with cancer. A cohort study was performed to evaluate the risk factors, antibiotic therapy, and outcomes of AmpC-EC bacteraemia in hospitalized cancer patients from September 2012 through December 2015. Two hundred forty-eight cases of E. coli bacteraemia were documented in cancer patients, 51 (20.6%) were caused by AmpC-EC and 197 (79.4%) were caused with non-AmpC-EC. Prior exposure to cephalosporins (OR 2...
April 12, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28434558/resistance-profiles-and-risk-factors-of-resistant-microorganisms-in-bacteraemia-of-abdominal-origin
#11
J Martín Jaramago, R Armero Ibáñez, J J Camarena Miñana, M Morales Suárez-Varela
OBJECTIVE: The presence of resistant microorganisms is a major cause of failure in initial empirical antimicrobial therapy. The objectives of this study are to determine the resistance profile of microorganisms that cause bacteraemia of abdominal origin and to identify whether the previous use of antibiotics and the place of acquisition of bacteraemia are risk factors associated with the presence of resistant organisms. MATERIAL AND METHODS: A clinical, observational, epidemiological, retrospective cohort study was conducted with all the adult patients admitted to a university hospital from 2011-2013...
April 20, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28431478/successful-treatment-of-multidrug-resistant-acinetobacter-baumannii-meningitis-with-ampicillin-sulbactam-in-primary-hospital
#12
Leitao Sun, Xiaohong Wang, Zefu Li
INTRODUCTION: Acinetobacter baumannii nosocomial infections, especially those due to multi-drug resistant strains, are increasingly detected. We want to find the effective treatment measures about multi-resistant Acinetobacter baumannii infections through this research. METHODOLOGY: The clinical features and the outcomes of twelve cases of nosocomial Acinetobacter baumannii meningitis treated with ampicillin sulbactam and intrathecal use of amikacin are reported in primary hospital...
April 21, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28428532/ceftriaxone-induced-hemolytic-anemia-in-a-jehovah-s-witness
#13
James Tasch, Pedro Gonzalez-Zayaz
BACKGROUND Drug-induced immune hemolytic anemia (DIIHA) is a rare condition that may result from the administration of an antibiotic, most notably the cephalosporin class, commonly used in both the adult and pediatric populations. A delay in recognition by a provider may lead to continuation of the offending agent and possibly result in fatal outcomes. CASE REPORT We report the case of a 65-year-old woman on ceftriaxone infusions after being diagnosed with acute mitral valve endocarditis 3 weeks prior, which presented with severe anemia and bilateral transient vision loss...
April 21, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28423957/trends-in-culprit-drugs-and-clinical-entities-in-cutaneous-adverse-drug-reactions-a-retrospective-study
#14
Fang Wang, Yu-Kun Zhao, Minyi Li, Zhe Zhu, Xingqi Zhang
PURPOSE: Morbidity due to cutaneous adverse drug reactions (CADRs) is quite common. The specific culprit drugs change over time and clinicians must be kept informed with updated knowledge, thus preventing potential CADRs. This retrospective study is a survey of CADRs encountered in a hospital-based population in Southern China during three time intervals, from 1984 to 2015. MATERIALS AND METHODS: The clinical records were review of 306 patients with CADRs who were admitted to our hospital from 2011 to 2015...
April 19, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28421643/empiric-antibiotic-regimens-for-neonatal-sepsis-in-australian-and-new-zealand-neonatal-intensive-care-units
#15
Jeremy P Carr, David P Burgner, Rohan S Hardikar, Jim P Buttery
AIM: Neonatal sepsis remains an important cause of morbidity and mortality, and requires prompt empiric treatment. However, only a minority of babies who receive antibiotics for suspected sepsis have an infection. Antimicrobial exposure in infancy has important short- and long-term consequences. There is no consensus regarding empirical antimicrobial regimens. METHODS: The study included a survey of empiric antimicrobial regimens in all tertiary neonatal intensive care units in Australia and New Zealand in 2013-2014...
April 19, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28418308/chromosomal-16s-ribosomal-rna-methyltransferase-rmte1-in-escherichia-coli-sequence-type-448
#16
Bin Li, Marissa P Pacey, Yohei Doi
We identified rmtE1, an uncommon 16S ribosomal methyltransferase gene, in an aminoglycoside- and cephalosporin-resistant Escherichia coli sequence type 448 clinical strain co-harboring blaCMY-2. Long-read sequencing revealed insertion of a 101,257-bp fragment carrying both resistance genes to the chromosome. Our findings underscore E. coli sequence type 448 as a potential high-risk multidrug-resistant clone.
May 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28413497/antibiotic-de-escalation-principle-in-elderly-patients-with-chronic-obstructive-pulmonary-disease-complicated-with-severe-pneumonia
#17
Baohong Xiao, Mei Wang, Xiaoling Hu, Jinfeng Li, Fangfang Wang, Jiaxing Sun
The present study investigated the clinical effect of antibiotic de-escalation therapy in elderly patients with chronic obstructive pulmonary disease (COPD) complicated with severe pneumonia. According to the parity method of hospitalization number, 86 cases were selected and divided into the observation and control group with 43 cases each. Based on empirical antibiotic application, levofloxacin and cephalosporin antibiotics were used in the control group. After treatment for 3 days, the regimen was adjusted to antibiotics active against Gram-positive (G+) and Gram-negative (G-) bacteria such as the third or fourth generation cephalosporin antibiotics, combined with aminoglycoside, or macrolide antibiotics according to their effects...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28411217/transfer-potential-of-plasmids-encoding-extended-spectrum-cephalosporin-resistance-in-escherichia-coli-from-poultry
#18
Solveig Sølverød Mo, Marianne Sunde, Hanna Karin Ilag, Solveig Langsrud, Even Heir
Escherichia coli resistant to extended-spectrum cephalosporins (ESC) are widely distributed in Norwegian broiler production, and the majority harbour transferable IncK or IncI1 plasmids with blaCMY-2 Persistent occurrence in broiler farms may occur through survival of ESC-resistant E. coli in the farm environment, or by transfer and maintenance of resistance plasmids within a population of environmental bacteria with high survival abilities. The aim of this study was to determine the transferability of two successful blaCMY-2 carrying plasmids belonging to the incompatibility groups IncK and IncI1, into E...
April 14, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28410852/cefiderocol-mic-quality-control-ranges-in-iron-depleted-cation-adjusted-mueller-hinton-broth-using-a-clsi-m23-a4-multi-laboratory-study-design
#19
Michael D Huband, Akinobu Ito, Masakatsu Tsuji, Helio S Sader, Kelley A Fedler, Robert K Flamm
Cefiderocol (formerly S-649266) is a new catechol-substituted parenteral siderophore cephalosporin with potent in vitro antibacterial activity against Gram-negative isolates including multidrug-resistant strains. A recent study following CLSI M23-A4 quality control guidelines established cefiderocol MIC QC ranges against Escherichia coli ATCC 25922 (0.06-0.5 μg/mL) and Pseudomonas aeruginosa ATCC 27853 (0.06-0.5 μg/mL).
March 23, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28408060/bacterial-epidemiology-and-antimicrobial-resistance-profiles-of-urinary-specimens-of-the-elderly
#20
F Gravey, G Loggia, A de La Blanchardière, V Cattoir
OBJECTIVE: Although urinary tract infections are the second leading cause of infections among patients aged above 65 years, data on bacterial epidemiology of urinary specimens in these patients is scarce. Our aim was to describe the main bacterial species found at significant levels in urine specimens of the elderly and to determine their antimicrobial resistance profiles. METHODS: From October 2012 to October 2015, all urinary specimens (catheter-related or not) received at the laboratory of microbiology of the university hospital of Caen (France) were retrospectively studied...
April 10, 2017: Médecine et Maladies Infectieuses
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