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brachytherapy boost breast cancer

Jessica Schuster, Christopher Chipko, Michael Kasper, Sandra Sha, Douglas Ciuba, James Petrikas, Anand Kuruvilla, Ravichandra Sandrapaty, Coral Quiet, Cynthia Anderson, Rashmi Benda, David Wazer, Jaroslaw Hepel, Douglas Arthur
PURPOSE: To report updated feasibility and reproducibility results for high-dose-rate noninvasive breast brachytherapy (NIBB) for tumor bed boost with whole breast radiation therapy (WBRT) in the setting of expanded patient and treatment facility number. METHODS AND MATERIALS: Fifteen independent community-based and academic centers reported 518 early-stage breast cancer patients from July 2007 to February 2015 on a privacy-encrypted online data registry. All patients' treatment included lumpectomy followed by combination of WBRT and NIBB...
October 6, 2016: Brachytherapy
Martje Marie Terheyden, Corinna Melchert, György Kovács
PURPOSE: This study aims to compare the dosimetric data of local tumor's bed dose escalation (boost) with photon beams (external beam radiation therapy - EBRT) versus high-dose-rate interstitial brachytherapy (HDR-BT) after breast-conserving treatment in women with early-stage breast cancer. MATERIAL AND METHODS: We analyzed the treatment planning data of 136 irradiated patients, treated between 2006 and 2013, who underwent breast-conserving surgery and adjuvant whole breast irradiation (WBI; 50...
August 2016: Journal of Contemporary Brachytherapy
Laurent Quéro, Sophie Guillerm, Naila Taright, Sophie Michaud, Luis Teixeira, Laurence Cahen-Doidy, Edwige Bourstyn, Marc Espié, Christophe Hennequin
PURPOSE: Breast conserving treatment, consisting of lumpectomy followed by whole-breast irradiation, is considered the standard of care in early-stage breast cancer. Randomized studies have reported that delivering boost doses to tumor bed improves local control rates, particularly in young women. This study sought to evaluate local control and cosmetic results of delivering boost doses using a high-dose-rate (HDR) brachytherapy (HDRBT) in breast cancer conservative treatment. METHODS: We included 621 T1-T2, N0-N1 breast cancer patients who underwent lumpectomy, external irradiation (44Gy over 5weeks), and a boost dose of two fractions of 5Gy to the tumor bed by means of HDR iridium brachytherapy...
July 26, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Oliver J Ott, Vratislav Strnad, Guido Hildebrandt, Daniela Kauer-Dorner, Hellen Knauerhase, Tibor Major, Jaroslaw Łyczek, José Luis Guinot, Jürgen Dunst, Cristina Gutierrez Miguelez, Pavel Slampa, Michael Allgäuer, Kristina Lössl, Bülent Polat, György Kovács, Arnt-René Fischedick, Thomas G Wendt, Rainer Fietkau, Rolf-Dieter Kortmann, Alexandra Resch, Anna Kulik, Leo Arribas, Peter Niehoff, Ferran Guedea, Annika Schlamann, Richard Pötter, Christine Gall, Martina Malzer, Wolfgang Uter, Csaba Polgár
BACKGROUND AND PURPOSE: To compare early side effects and patient compliance of accelerated partial breast irradiation (APBI) with multicatheter brachytherapy to external beam whole breast irradiation (WBI) in a low-risk group of patients with breast cancer. MATERIAL AND METHODS: Between April 2004 and July 2009, 1328 patients with UICC stage 0-IIA breast cancer were randomized to receive WBI with 50Gy and a boost of 10Gy or APBI with either 32.0Gy/8 fractions, or 30...
July 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Alexandre M C Santos, Loredana G Marcu, Chia M Wong, Eva Bezak
AIMS: There is evidence towards the induction of second primary cancers (SPCs) after breast radiotherapy (RT). Organs, such as the lungs and the esophagus, have been identified as common sites for SPC formation. As a result, the current study investigated the risk of secondary carcinogenesis associated with particular RT techniques for breast cancer; including whole breast, segmented breast, partial breast and mammosite brachytherapy. METHODS: In this study, seven breast cancer patients had all major organs contoured on their planning computed tomography (CT) images...
July 5, 2016: Acta Oncologica
Tarcísio Passos Ribeiro de Campos, Carla Flavia de Lima, Ethel Mizrahy Cuperschmid
OBJECTIVE: To perform a comparative dosimetric analysis, based on computer simulations, of temporary balloon implants with (99m)Tc and balloon brachytherapy with high-dose-rate (HDR) (192)Ir, as boosts to radiotherapy. We hypothesized that the two techniques would produce equivalent doses under pre-established conditions of activity and exposure time. MATERIALS AND METHODS: Simulations of implants with (99m)Tc-filled and HDR (192)Ir-filled balloons were performed with the Siscodes/MCNP5, modeling in voxels a magnetic resonance imaging set related to a young female...
March 2016: Radiologia Brasileira
Mauricio Cambeiro, Fernando Martinez-Regueira, Natalia Rodriguez-Spiteri, Begoña Olartecoechea, Luis Pina Insausti, Arlette Elizalde, Miguel Idoate Gastearena, Jesús Sola Gallego, Marta Santisteban Eslava, Jose Manuel Aramendía, José Javier Aristu, Leire Arbea Moreno, Marta Moreno-Jiménez, German Valtueña, Rafael Martínez-Monge
PURPOSE: To assess the safety, feasibility, and efficacy of free-hand intraoperative multicatheter breast implant (FHIOMBI) and perioperative high-dose-rate brachytherapy (PHDRBT) in early breast cancer. METHODS AND MATERIALS: Patients with early breast cancer candidates for breast conservative surgery (BCS) were prospectively enrolled. Patients suitable for accelerated partial breast irradiation (APBI) (low or intermediate risk according GEC-ESTRO criteria) received PHDRBT (3...
July 2016: Brachytherapy
Matthew E Schutzer, Douglas W Arthur, Mitchell S Anscher
PURPOSE: Value in health care is defined as outcomes achieved per dollar spent, and understanding cost is critical to delivering high-value care. Traditional costing methods reflect charges rather than fundamental costs to provide a service. The more rigorous method of time-driven activity-based costing was used to compare cost between whole-breast radiotherapy (WBRT) and accelerated partial-breast irradiation (APBI) using balloon-based brachytherapy. MATERIALS AND METHODS: For WBRT (25 fractions with five-fraction boost) and APBI (10 fractions twice daily), process maps were created outlining each activity from consultation to post-treatment follow up...
May 2016: Journal of Oncology Practice
Judyta Wiercińska, Anna Wronczewska, Renata Kabacińska, Roman Makarewicz
PURPOSE: The purpose of this study is to evaluate our first experience with 3D image-guided breast brachytherapy and to compare dose distribution parameters between Paris dosimetry system (PDS) and image-based plans. MATERIAL AND METHODS: First 49 breast cancer patients treated with 3D high-dose-rate interstitial brachytherapy as a boost were selected for the study. Every patient underwent computed tomography, and the planning target volume (PTV) and organs at risk (OAR) were outlined...
December 2015: Journal of Contemporary Brachytherapy
Tibor Major, Cristina Gutiérrez, Benjamin Guix, Erik van Limbergen, Vratislav Strnad, Csaba Polgár
OBJECTIVE: To prepare guidelines for target definition and delineations after open cavity breast conserving surgery in accelerated partial breast irradiations or boost treatments using multicatheter interstitial brachytherapy based on the consensus of the Breast Working Group of GEC-ESTRO. METHOD: Following a study on interobserver variations of target volume delineation in multicatheter breast brachytherapy after open cavity surgery and a number of discussions in consensus meetings these guidelines were worked out by experts on the field...
January 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Alexander Gitt, Hugo Böse-Ribeiro, Carsten Nieder, Philipp Günther Kup, Horst Hermani, Helmut Bühler, Hasan Yavuz Ergönenç, Dorothee Drüppel, Irenäus Anton Adamietz, Khashayar Fakhrian
AIM: To report the initial outcomes of patients treated with the MammoSite brachytherapy device (MSBT) as a boost followed by external whole-breast irradiation (WBI). PATIENTS AND METHODS: From June 2011 to March 2014, 107 patients (typically with pT1-2, pN0-1, M0 disease) were treated with breast-conserving therapy and adjuvant radiotherapy with MSBT (15 Gy in 2.5-Gy fractions) followed by WBI (median=50.4 Gy). Toxicity was classified according to the Common Terminology Criteria for Adverse Events v3...
January 2016: Anticancer Research
Mourougan Sinnatamby, Vivekanandan Nagarajan, Sathyanarayana Reddy K, Gunaseelan Karunanidhi, Vivekanandam Singhavajala
PURPOSE: Radiotherapy for breast cancer includes different techniques and methods. The purpose of this study is to compare dosimetric calculations using TG-43 dose formalism and Varian Acuros™ BV (GBBS) dose calculation algorithm for interstitial implant of breast using metal catheters in high-dose-rate (HDR) brachytherapy, using (192)Ir. MATERIAL AND METHODS: Twenty patients who were considered for breast conservative surgery (BCS), underwent lumpectomy and axillary dissection...
August 2015: Journal of Contemporary Brachytherapy
Vratislav Strnad, Oliver J Ott, Guido Hildebrandt, Daniela Kauer-Dorner, Hellen Knauerhase, Tibor Major, Jaroslaw Lyczek, Jose Luis Guinot, Jürgen Dunst, Cristina Gutierrez Miguelez, Pavel Slampa, Michael Allgäuer, Kristina Lössl, Bülent Polat, György Kovács, Arnt-René Fischedick, Thomas G Wendt, Rainer Fietkau, Marion Hindemith, Alexandra Resch, Anna Kulik, Leo Arribas, Peter Niehoff, Fernando Guedea, Annika Schlamann, Richard Pötter, Christine Gall, Martina Malzer, Wolfgang Uter, Csaba Polgár
BACKGROUND: In a phase 3, randomised, non-inferiority trial, accelerated partial breast irradiation (APBI) for patients with stage 0, I, and IIA breast cancer who underwent breast-conserving treatment was compared with whole-breast irradiation. Here, we present 5-year follow-up results. METHODS: We did a phase 3, randomised, non-inferiority trial at 16 hospitals and medical centres in seven European countries. 1184 patients with low-risk invasive and ductal carcinoma in situ treated with breast-conserving surgery were centrally randomised to either whole-breast irradiation or APBI using multicatheter brachytherapy...
January 16, 2016: Lancet
Ramona K Charaghvandi, Mariska D den Hartogh, Anne-Mar L N van Ommen, Wilfred J H de Vries, Vincent Scholten, Marinus A Moerland, Mariëlle E P Philippens, Rogier I Schokker, Marco van Vulpen, Bram van Asselen, Desirée H J G van den Bongard
BACKGROUND AND PURPOSE: A radiosurgical treatment approach for early-stage breast cancer has the potential to minimize the patient's treatment burden. The dosimetric feasibility for single fraction ablative radiotherapy was evaluated by comparing volumetric modulated arc therapy (VMAT) with an interstitial multicatheter brachytherapy (IMB) approach. METHODS AND MATERIALS: The tumors of 20 patients with early-stage breast cancer were delineated on a preoperative contrast-enhanced planning CT-scan, co-registered with a contrast-enhanced magnetic resonance imaging (MRI), both in radiotherapy supine position...
December 2015: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Janusz Skowronek, Adam Chicheł
Breast conserving surgery (BCS) with following external beam radiation therapy (EBRT) of the conserved breast has become widely accepted in the last decades for the treatment of early invasive breast cancer. The standard technique of EBRT after BCS is to treat the whole breast up to a total dose of 42.5 to 50 Gy. An additional dose is given to treated volume as a boost to a portion of the breast. In the early stage of breast cancer, research has shown that the area requiring radiation treatment to prevent the cancer from local recurrence is the breast tissue that surrounds the area where the initial cancer was removed...
March 2014: Przeglad Menopauzalny, Menopause Review
Vratislav Strnad, Jean-Michel Hannoun-Levi, Jose-Luis Guinot, Kristina Lössl, Daniela Kauer-Dorner, Alexandra Resch, György Kovács, Tibor Major, Erik Van Limbergen
OBJECTIVE: The aim was to develop a delineation guideline for target definition for APBI or boost by consensus of the Breast Working Group of GEC-ESTRO. PROPOSED RECOMMENDATIONS: Appropriate delineation of CTV (PTV) with low inter- and intra-observer variability in clinical practice is complex and needs various steps as: (1) Detailed knowledge of primary surgical procedure, of all details of pathology, as well as of preoperative imaging. (2) Definition of tumour localization before breast conserving surgery inside the breast and translation of this information in the postoperative CT imaging data set...
June 2015: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Cristina Gutiérrez, Dina Najjari, Evelyn Martínez, Saray Botella, Arantxa Eraso, Francisco Pino, Ferran Moreno, Joan Pera, Ferran Guedea
PURPOSE: To demonstrate the utility of a boost with interstitial brachytherapy (BT) in breast-conserving therapy (BCT) by doing a thorough review of the literature and describing in detail our technique for delivering this boost. MATERIAL AND METHODS: Our department has been delivering the boost with interstitial BT since 1989, in most cases with rigid needles and a theoretical dosimetry. In the early years, we used low-dose-rate (LDR) with iridium-192 wires. The dose administered was 15 Gy if there were no risk factors for local relapse or 20-25 Gy in the presence of risk factors...
January 2015: Journal of Contemporary Brachytherapy
Karolien Verhoeven, Isabelle Kindts, Annouschka Laenen, Stéphanie Peeters, Hilde Janssen, Erik Van Limbergen, Caroline Weltens
PURPOSE: Compare different boost techniques after breast conserving therapy (BCT) in terms of local and loco-regional recurrences. MATERIALS AND METHODS: From 2000 to 2005, patients treated with BCT for invasive breast cancer (BC) were included. An electron boost (EB) was performed for a superficial boost-volume (less than 29 mm under the epidermis), in all other cases a brachytherapy boost (BTB) was proposed. When patients refused a BTB or it was not possible for technical reasons, a photon boost (PB) was given...
August 2015: Breast: Official Journal of the European Society of Mastology
Jose-Luis Guinot, Cristobal Baixauli-Perez, Pablo Soler, Maria Isabel Tortajada, Araceli Moreno, Miguel Angel Santos, Alejandro Mut, Francisco Gozalbo, Leoncio Arribas
PURPOSE: To evaluate the local control rate and complications of a single fraction of high-dose-rate brachytherapy (HDR BT) boost in women aged 45 yeas and younger after breast-conserving therapy. METHODS AND MATERIALS: Between 1999 and 2007, 167 patients between the ages of 26 and 45 years old (72 were 40 years old or younger), with stages T1 to T2 invasive breast cancer with disease-free margin status of at least 5 mm after breast-conserving surgery received 46 to 50 Gy whole-breast irradiation plus a 7-Gy HDR-BT boost ("fast boost")...
January 1, 2015: International Journal of Radiation Oncology, Biology, Physics
Jaroslaw T Hepel, Kara L Leonard, Jessica R Hiatt, Thomas A DiPetrillo, David E Wazer
PURPOSE: Noninvasive image-guided breast brachytherapy (NIBB) allows for accurate targeting of the tumor bed (TB) for breast boost by using breast immobilization and image guidance. However, not all patients are candidates for this technique. METHODS: Consecutive patients treated for breast cancer were evaluated. Patients with very small breast size (cup ≤ A) for whom immobilization could not be achieved were treated with electrons. All others underwent simulation for NIBB boost...
November 2014: Brachytherapy
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