Paul M Coen, Zhiguang Huo, Gregory J Tranah, Haley N Barnes, Xiping Zhang, Christopher A Wolff, Kevin Wu, Peggy M Cawthon, Russell T Hepple, Frederico G S Toledo, Daniel S Evans, Olaya Santiago-Fernández, Ana Maria Cuervo, Stephen B Kritchevsky, Anne B Newman, Steven R Cummings, Karyn A Esser
Autophagy is essential for proteostasis, energetic balance, and cell defense and is a key pathway in aging. Identifying associations between autophagy gene expression patterns in skeletal muscle and physical performance outcomes would further our knowledge of mechanisms related with proteostasis and healthy aging. Muscle biopsies were obtained from participants in the Study of Muscle, Mobility, and Aging (SOMMA). For 575 participants, RNA was sequenced and expression of 281 genes related to autophagy regulation, mitophagy, and mTOR/upstream pathways was determined...
April 16, 2024: Aging Cell