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Deep Oscilation Therapy

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https://www.readbyqxmd.com/read/27797341/neuronal-firing-patterns-outweigh-circuitry-oscillations-in-parkinsonian-motor-control
#1
Ming-Kai Pan, Sheng-Han Kuo, Chun-Hwei Tai, Jyun-You Liou, Ju-Chun Pei, Chia-Yuan Chang, Yi-Mei Wang, Wen-Chuan Liu, Tien-Rei Wang, Wen-Sung Lai, Chung-Chin Kuo
Neuronal oscillations at beta frequencies (20-50 Hz) in the cortico-basal ganglia circuits have long been the leading theory for bradykinesia, the slow movements that are cardinal symptoms in Parkinson's disease (PD). The beta oscillation theory helped to drive a frequency-based design in the development of deep brain stimulation therapy for PD. However, in contrast to this theory, here we have found that bradykinesia can be completely dissociated from beta oscillations in rodent models. Instead, we observed that bradykinesia is causatively regulated by the burst-firing pattern of the subthalamic nucleus (STN) in a feed-forward, or efferent-only, mechanism...
December 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27771287/subthalamic-stimulation-and-levodopa-modulate-cortical-reactivity-in-parkinson-s-patients
#2
Elias Paolo Casula, Mario Stampanoni Bassi, Maria Concetta Pellicciari, Viviana Ponzo, Domenica Veniero, Antonella Peppe, Livia Brusa, Paolo Stanzione, Carlo Caltagirone, Alessandro Stefani, Giacomo Koch
BACKGROUND: The effects of deep brain stimulation of the subthalamic nucleus (DBS-STN) and L-dopa (LD) on cortical activity in Parkinson's disease (PD) are poorly understood. OBJECTIVES: By combining transcranial magnetic stimulation (TMS) and electroencephalography (EEG) we explored the effects of STN-DBS, either alone or in combination with L-Dopa (LD), on TMS-evoked cortical activity in a sample of implanted PD patients. METHODS: PD patients were tested in three clinical conditions: i) LD therapy with STN-DBS turned on (ON/ON condition); ii) without LD therapy with STN-DBS turned on (OFF/ON condition); iii) without LD therapy with STN-DBS turned off (OFF/OFF condition)...
October 17, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27553876/subthalamic-beta-oscillations-are-attenuated-after-withdrawal-of-chronic-high-frequency-neurostimulation-in-parkinson-s-disease
#3
Megan H Trager, Mandy Miller Koop, Anca Velisar, Zack Blumenfeld, Judy Syrkin Nikolau, Emma J Quinn, Talora Martin, Helen Bronte-Stewart
Subthalamic nucleus (STN) local field potential (LFP) recordings demonstrate beta (13-30Hz) band oscillations in Parkinson's disease (PD) defined as elevations of spectral power. The amount of attenuation of beta band power on therapeutic levels of high frequency (HF) deep brain stimulation (DBS) and/or dopaminergic medication has been correlated with the degree of improvement in bradykinesia and rigidity from the therapy, which has led to the suggestion that elevated beta band power is a marker of PD motor disability...
August 21, 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/27548234/deep-brain-stimulation-frequency-a-divining-rod-for-new-and-novel-concepts-of-nervous-system-function-and-therapy
#4
REVIEW
Erwin B Montgomery, Huang He
The efficacy of Deep Brain Stimulation (DBS) for an expanding array of neurological and psychiatric disorders demonstrates directly that DBS affects the basic electroneurophysiological mechanisms of the brain. The increasing array of active electrode configurations, stimulation currents, pulse widths, frequencies, and pulse patterns provides valuable tools to probe electroneurophysiological mechanisms. The extension of basic electroneurophysiological and anatomical concepts using sophisticated computational modeling and simulation has provided relatively straightforward explanations of all the DBS parameters except frequency...
August 17, 2016: Brain Sciences
https://www.readbyqxmd.com/read/27524960/longitudinal-changes-in-depressive-circuitry-in-response-to-neuromodulation-therapy
#5
Yagna Pathak, Oludamilola Salami, Sylvain Baillet, Zhimin Li, Christopher R Butson
BACKGROUND: Major depressive disorder (MDD) is a public health problem worldwide. There is increasing interest in using non-invasive therapies such as repetitive transcranial magnetic stimulation (rTMS) to treat MDD. However, the changes induced by rTMS on neural circuits remain poorly characterized. The present study aims to test whether the brain regions previously targeted by deep brain stimulation (DBS) in the treatment of MDD respond to rTMS, and whether functional connectivity (FC) measures can predict clinical response...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27469471/viability-of-endothelial-cells-after-ultrasound-mediated-sonoporation-influence-of-targeting-oscillation-and-displacement-of-microbubbles
#6
Tom van Rooij, Ilya Skachkov, Inés Beekers, Kirby R Lattwein, Jason D Voorneveld, Tom J A Kokhuis, Deep Bera, Ying Luan, Antonius F W van der Steen, Nico de Jong, Klazina Kooiman
Microbubbles (MBs) have been shown to create transient or lethal pores in cell membranes under the influence of ultrasound, known as ultrasound-mediated sonoporation. Several studies have reported enhanced drug delivery or local cell death induced by MBs that are either targeted to a specific biomarker (targeted microbubbles, tMBs) or that are not targeted (non-targeted microbubbles, ntMBs). However, both the exact mechanism and the optimal acoustic settings for sonoporation are still unknown. In this study we used real-time uptake patterns of propidium iodide, a fluorescent cell impermeable model drug, as a measure for sonoporation...
September 28, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27382739/-influence-of-medication-on-the-oscillatory-and-dynamic-characteristics-of-subthalamic-local-field-potentials-in-patients-with-parkinson-s-disease
#7
Yanan Wang, Xinyi Geng, Yongzhi Huang, Shouyan Wang
The dysfunction of subthalamic nucleus is the main cause of Parkinson's disease. Local field potentials in human subthalamic nucleus contain rich physiological information. The present study aimed to quantify the oscillatory and dynamic characteristics of local field potentials of subthalamic nucleus, and their modulation by the medication therapy for Parkinson's disease. The subthalamic nucleus local field potentials were recorded from patients with Parkinson's disease at the states of on and off medication...
February 2016: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/27307233/gamma-oscillations-in-the-hyperkinetic-state-detected-with-chronic-human-brain-recordings-in-parkinson-s-disease
#8
Nicole C Swann, Coralie de Hemptinne, Svjetlana Miocinovic, Salman Qasim, Sarah S Wang, Nathan Ziman, Jill L Ostrem, Marta San Luciano, Nicholas B Galifianakis, Philip A Starr
UNLABELLED: Hyperkinetic states are common in human movement disorders, but their neural basis remains uncertain. One such condition is dyskinesia, a serious adverse effect of medical and surgical treatment for Parkinson's disease (PD). To study this, we used a novel, totally implanted, bidirectional neural interface to obtain multisite long-term recordings. We focus our analysis on two patients with PD who experienced frequent dyskinesia and studied them both at rest and during voluntary movement...
June 15, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27303288/a-compendium-of-preparation-and-application-of-stem-cells-in-parkinson-s-disease-current-status-and-future-prospects
#9
REVIEW
Yan Shen, Jinsha Huang, Ling Liu, Xiaoyun Xu, Chao Han, Guoxin Zhang, Haiyang Jiang, Jie Li, Zhicheng Lin, Nian Xiong, Tao Wang
Parkinson's Disease (PD) is a progressively neurodegenerative disorder, implicitly characterized by a stepwise loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) and explicitly marked by bradykinesia, rigidity, resting tremor and postural instability. Currently, therapeutic approaches available are mainly palliative strategies, including L-3,4-dihydroxy-phenylalanine (L-DOPA) replacement therapy, DA receptor agonist and deep brain stimulation (DBS) procedures. As the disease proceeds, however, the pharmacotherapeutic efficacy is inevitably worn off, worse still, implicated by side effects of motor response oscillations as well as L-DOPA induced dyskinesia (LID)...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27273305/deep-brain-stimulation-mechanisms-the-control-of-network-activity-via-neurochemistry-modulation
#10
Cameron C McIntyre, Ross W Anderson
Deep brain stimulation (DBS) has revolutionized the clinical care of late-stage Parkinson's disease and shows promise for improving the treatment of intractable neuropsychiatric disorders. However, after over 25 years of clinical experience, numerous questions still remain on the neurophysiological basis for the therapeutic mechanisms of action. At their fundamental core, the general purpose of electrical stimulation therapies in the nervous system are to use the applied electric field to manipulate the opening and closing of voltage-gated sodium channels on neurons, generate stimulation induced action potentials, and subsequently, control the release of neurotransmitters in targeted pathways...
June 8, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27046426/specialist-approaches-to-managing-lipoedema
#11
Amy Fetzer
While there is no proven cure for lipoedema, early detection is key as specialist treatments, complemented by self-management techniques, can improve symptoms and prevent progression. There is no universal approach as the correct treatment or treatments will depend on each patient's particular circumstances; however, when chosen early and appropriately, interventions can provide huge benefits. The most common treatments in the management of lipoedema include compression, manual lymphatic drainage (MLD), tumescent liposuction, intermittent pneumatic compression therapy (IPC), kinesio taping, deep oscillation therapy, and cognitive behavioural therapy (CBT)...
April 2016: British Journal of Community Nursing
https://www.readbyqxmd.com/read/26889477/towards-precision-medicine-in-epilepsy-surgery
#12
REVIEW
Pingping Jin, Dongyan Wu, Xiaoxuan Li, Liankun Ren, Yuping Wang
Up to a third of all patients with epilepsy are refractory to medical therapy even in the context of the introduction of new antiepileptic drugs (AEDs) with considerable advantages in safety and tolerability over the last two decades. It has been widely accepted that epilepsy surgery is a highly effective therapeutic option in a selected subset of patients with refractory focal seizure. There is no doubt that accurate localization of the epileptogenic zone (EZ) is crucial to the success of resection surgery for intractable epilepsy...
January 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/26608605/high-frequency-deep-brain-stimulation-and-neural-rhythms-in-parkinson-s-disease
#13
REVIEW
Zack Blumenfeld, Helen Brontë-Stewart
High frequency (HF) deep brain stimulation (DBS) is an established therapy for the treatment of Parkinson's disease (PD). It effectively treats the cardinal motor signs of PD, including tremor, bradykinesia, and rigidity. The most common neural target is the subthalamic nucleus, located within the basal ganglia, the region most acutely affected by PD pathology. Using chronically-implanted DBS electrodes, researchers have been able to record underlying neural rhythms from several nodes in the PD network as well as perturb it using DBS to measure the ensuing neural and behavioral effects, both acutely and over time...
December 2015: Neuropsychology Review
https://www.readbyqxmd.com/read/26541381/computational-neurostimulation-for-parkinson-s-disease
#14
REVIEW
Simon Little, Sven Bestmann
Deep brain stimulation (DBS) has had a remarkable success in treating a range of neurological and psychiatric conditions. However, efficacy remains suboptimal and patients can often develop side effects. The underlying causes of both the beneficial and detrimental effects of DBS remain incompletely understood which is delaying improvements to current DBS therapies and limiting developments of future treatments. Advancing this mechanistic understanding will require the design of appropriate models that can formalize the interaction between DBS and the cortico-basal-ganglia network...
2015: Progress in Brain Research
https://www.readbyqxmd.com/read/26459154/lethal-hypophosphatasia-successfully-treated-with-enzyme-replacement-from-day-1-after-birth
#15
Yoko Okazaki, Hiroyuki Kitajima, Narutaka Mochizuki, Taichi Kitaoka, Toshimi Michigami, Keiichi Ozono
UNLABELLED: Hypophosphatasia (HPP) is a rare metabolic bone disease caused by loss-of-function mutations in the gene ALPL encoding the tissue nonspecific alkaline phosphatase (TNSALP). There is a broad range of severity in the phenotype of HPP, and the most severe form exhibits perinatal lethality without mineralization of the skeleton. Here, we describe a female infant with perinatal lethal HPP diagnosed in utero. She was treated with a recombinant ALP (asfotase alfa) as an enzyme replacement therapy (ERT), which started from 1 day after birth...
March 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/26425697/astroglial-control-of-the-antidepressant-like-effects-of-prefrontal-cortex-deep-brain-stimulation
#16
A Etiévant, C Oosterhof, C Bétry, E Abrial, M Novo-Perez, R Rovera, H Scarna, C Devader, J Mazella, G Wegener, C Sánchez, O Dkhissi-Benyahya, C Gronfier, V Coizet, J M Beaulieu, P Blier, G Lucas, N Haddjeri
Although deep brain stimulation (DBS) shows promising efficacy as a therapy for intractable depression, the neurobiological bases underlying its therapeutic action remain largely unknown. The present study was aimed at characterizing the effects of infralimbic prefrontal cortex (IL-PFC) DBS on several pre-clinical markers of the antidepressant-like response and at investigating putative non-neuronal mechanism underlying DBS action. We found that DBS induced an antidepressant-like response that was prevented by IL-PFC neuronal lesion and by adenosine A1 receptor antagonists including caffeine...
August 2015: EBioMedicine
https://www.readbyqxmd.com/read/26355815/hippocampal-closed-loop-modeling-and-implications-for-seizure-stimulation-design
#17
Roman A Sandler, Dong Song, Robert E Hampson, Sam A Deadwyler, Theodore W Berger, Vasilis Z Marmarelis
OBJECTIVE: Traditional hippocampal modeling has focused on the series of feedforward synapses known as the trisynaptic pathway. However, feedback connections from CA1 back to the hippocampus through the entorhinal cortex (EC) actually make the hippocampus a closed-loop system. By constructing a functional closed-loop model of the hippocampus, one may learn how both physiological and epileptic oscillations emerge and design efficient neurostimulation patterns to abate such oscillations...
October 2015: Journal of Neural Engineering
https://www.readbyqxmd.com/read/26334006/cholinergic-mechanisms-of-high-frequency-stimulation-in-entopeduncular-nucleus
#18
Feng Luo, Zelma H T Kiss
Chronic, high-frequency (>100 Hz) electrical stimulation, known as deep brain stimulation (DBS), of the internal segment of the globus pallidus (GPi) is a highly effective therapy for Parkinson's disease (PD) and dystonia. Despite some understanding of how it works acutely in PD models, there remain questions about its mechanisms of action. Several hypotheses have been proposed, such as depolarization blockade, activation of inhibitory synapses, depletion of neurotransmitters, and/or disruption/alteration of network oscillations...
January 1, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/26096267/septohippocampal-neuromodulation-improves-cognition-after-traumatic-brain-injury
#19
Darrin J Lee, Gene G Gurkoff, Ali Izadi, Stacey E Seidl, Angela Echeverri, Mikhail Melnik, Robert F Berman, Arne D Ekstrom, J Paul Muizelaar, Bruce G Lyeth, Kiarash Shahlaie
Traumatic brain injury (TBI) often results in persistent attention and memory deficits that are associated with hippocampal dysfunction. Although deep brain stimulation (DBS) is used to treat neurological disorders related to motor dysfunction, the effectiveness of stimulation to treat cognition remains largely unknown. In this study, adult male Harlan Sprague-Dawley rats underwent a lateral fluid percussion or sham injury followed by implantation of bipolar electrodes in the medial septal nucleus (MSN) and ipsilateral hippocampus...
November 15, 2015: Journal of Neurotrauma
https://www.readbyqxmd.com/read/25830275/massage-therapy-improves-in-vitro-fertilization-outcome-in-patients-undergoing-blastocyst-transfer-in-a-cryo-cycle
#20
Jasmin Okhowat, Maximilian Murtinger, Maximilian Schuff, Johannes Wogatzky, Dietmar Spitzer, Pierre Vanderzwalmen, Barbara Wirleitner, Nicolas Herbert Zech
CONTEXT: Massage therapy is increasingly used to relieve physical and mental discomfort and is suggested as a safe therapeutic modality, without any significant risks or any known side effects. Although a multitude of complementary therapies, such as acupuncture, are applied in reproductive medicine, no information is available with regard to the application of massage as an adjuvant therapy in assisted-reproduction techniques (ARTs). OBJECTIVES: This study was intended to assess the effectiveness of a deep relaxation (andullation) therapy based on oscillating vibrations when used prior to embryo transfer (ET) in in vitro fertilization (IVF) cryo-cycles...
March 2015: Alternative Therapies in Health and Medicine
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