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Ngan Nguyen, Ronald Dean Franz, Omar Mohammed, Richard Huynh, Christine Kim Son, Rida Nusrat Khan, Bilawal Ahmed
BACKGROUND: Large cell neuroendocrine carcinoma (LCNEC) is a rare subtype of prostate cancer. The pathogenesis, clinical manifestation, treatment options, and prognosis are uncertain and underreported. MATERIALS AND METHODS: A systematic search was conducted in April 2022 through PubMed, Embase, and Cochrane. We reviewed cases of LCNEC developed either from de novo or transformation from prostate adenocarcinoma and summarized the relevant pathophysiological course, treatment options, and outcomes...
2024: Frontiers in Oncology
#2
REVIEW
Leonardo Franz, Gino Marioni, Antonio Mazzoni, Cosimo de Filippis, Elisabetta Zanoletti
During the last decades, neuro-otological surgery has progressively reduced functional morbidity, including facial nerve damage. However, the occurrence of this sequela may significantly impact on patients' quality of life. The aim of this narrative review is to provide an update on the patho-physiological and clinical issues related to facial nerve damage in oto-neurological and skull base surgery, in the light of a comprehensive therapeutic and rehabilitative approach to iatrogenic disfunctions. The narrative review is based on a search in the PubMed, Scopus, and Web of Science databases...
October 27, 2023: Journal of Clinical Medicine
#3
JOURNAL ARTICLE
Kira Tosefsky, Alexander D Rebchuk, Justin Z Wang, Yosef Ellenbogen, Richard Drexler, Franz L Ricklefs, Thomas Sauvigny, Ulrich Schüller, Christopher B Cutler, Brandon Lucke-Wold, Yusuf Mehkri, Sanju Lama, Garnette R Sutherland, Michael Karsy, Brian L Hoh, Manfred Westphal, Gelareh Zadeh, Stephen Yip, Serge Makarenko
OBJECTIVE: Grade 3 meningioma represents a rare meningioma subtype, for which limited natural history data are available. The objective of this study was to identify demographics and pathologic characteristics, clinical and functional status outcomes, and prognostic factors in an international cohort of grade 3 meningioma patients. METHODS: Clinical and histopathological data were collected for patients treated at 7 sites across North America and Europe between 1991 and 2022...
August 11, 2023: Journal of Neurosurgery
#4
JOURNAL ARTICLE
Krystian Kaczmarek, Henning Plage, Kira Furlano, Sebastian Hofbauer, Sarah Weinberger, Bernhard Ralla, Antonia Franz, Annika Fendler, Michela de Martino, Florian Roßner, Simon Schallenberg, Sefer Elezkurtaj, Martina Kluth, Maximilian Lennartz, Niclas C Blessin, Andreas H Marx, Henrik Samtleben, Margit Fisch, Michael Rink, Marcin Slojewski, Thorsten Ecke, Steffen Hallmann, Stefan Koch, Nico Adamini, Sarah Minner, Ronald Simon, Guido Sauter, Joachim Weischenfeldt, Tobias Klatte, Thorsten Schlomm, David Horst, Henrik Zecha
BACKGROUND: Uroplakin-1a (Upk1a) and uroplakin-1b (Upk1b) have recently been identified as diagnostic markers for the distinction of urothelial carcinomas from other solid tumor entities. Both proteins play an important role in the stabilization and strengthening of epithelial cells that line the bladder. METHODS: To evaluate the prognostic role of uroplakin expression in urothelial carcinomas, more than 2700 urothelial neoplasms were analyzed in a tissue microarray format by immunohistochemistry...
October 1, 2023: International Urology and Nephrology
#5
JOURNAL ARTICLE
Dimo Dietrich, Simone Weider, Luka de Vos, Timo Jakob Vogt, Moritz Färber, Romina Zarbl, Alina Hunecke, Ann-Kathrin Glosch, Jennis Gabrielpillai, Friedrich Bootz, Franz-Georg Bauernfeind, Franz-Josef Kramer, Glen Kristiansen, Peter Brossart, Sebastian Strieth, Alina Franzen
BACKGROUND: Tumorous SEPT9 (septin 9, SEPTIN9) circulating cell-free DNA (ccfDNA) methylation in blood plasma is a powerful biomarker for diagnosis, molecular staging, prognosis, and recurrence monitoring in head and neck squamous cell carcinoma (HNSCC) patients. The present study aimed to evaluate the clinical performance of SEPT9 ccfDNA methylation to detect post-surgical minimal residual disease (MRD) in patients with localized or locally advanced HNSCC treated with curative intent...
July 21, 2023: Clinical Chemistry
#6
JOURNAL ARTICLE
Markus Schweipert, Anuja Amurthavasan, Franz-Josef Meyer-Almes
AIM: Human histone deacetylase 8 (KDAC8) is a well-recognized pharmaceutical target in Cornelia de Lange syndrome and different types of cancer, particularly childhood neuroblastoma. Several classes of chemotypes have been identified, which interfere with the enzyme activity of KDAC8. These compounds have been identified under equilibrium or near equilibrium conditions for inhibitor binding to the target enzyme. This study aims for the classification of KDAC8 inhibitors according to the mode of action and identification of most promising lead compounds for drug development...
2023: Exploration of targeted anti-tumor therapy
#7
JOURNAL ARTICLE
Valentina Albanese, Sonia Missiroli, Mariasole Perrone, Martina Fabbri, Caterina Boncompagni, Salvatore Pacifico, Tiziano De Ventura, Antonella Ciancetta, Giulio Dondio, Franz Kricek, Paolo Pinton, Remo Guerrini, Delia Preti, Carlotta Giorgi
The NLRP3 inflammasome is a critical component of innate immunity that senses diverse pathogen- and host-derived molecules. However, its aberrant activation has been associated with the pathogenesis of multiple diseases, including cancer. In this study, we designed and synthesized a series of aryl sulfonamide derivatives (ASDs) to inhibit the NLRP3 inflammasome. Among these, compounds 6c , 7n , and 10 specifically inhibited NLRP3 activation at nanomolar concentrations without affecting the activation of the NLRC4 and AIM2 inflammasomes...
March 27, 2023: Journal of Medicinal Chemistry
#8
JOURNAL ARTICLE
Zakile A Mfumbilwa, Janneke A Wilschut, Martijn J H G Simons, Bram Ramaekers, Manuela Joore, Valesca Retèl, Christine M Cramer-van der Welle, Franz M N H Schramel, Ewoudt M W van de Garde, Veerle M H Coupé
Recent discoveries in molecular diagnostics and drug treatments have improved the treatment of patients with advanced (inoperable) non-squamous non-small cell lung cancer (NSCLC) from solely platinum-based chemotherapy to more personalized treatment, including targeted therapies and immunotherapies. However, these improvements come at considerable costs, highlighting the need to assess their cost-effectiveness in order to optimize lung cancer care. Traditionally, cost-effectiveness models for the evaluation of new lung cancer treatments were based on the findings of the randomized control trials (RCTs)...
February 9, 2023: Scientific Reports
#9
JOURNAL ARTICLE
Luana Roberta Michels, Flávia Nathiely Silveira Fachel, Roselena Silvestri Schuh, Juliana Hofstätter Azambuja, Priscila Oliveira de Souza, Nicolly Espindola Gelsleichter, Gabriela Spies Lenz, Fernanda Visioli, Elizandra Braganhol, Helder Ferreira Teixeira
Glioblastoma (GB) is the worst and most common primary brain tumor. Temozolomide (TMZ), an alkylating agent, is widely used for treating primary and recurrent high-grade gliomas. However, at least 50% of TMZ treated patients do not respond to TMZ and the development of chemoresistance is a major problem. Here, we designed a lipid nanoemulsion containing a thermoresponsive polymer (poloxamer 407) aiming to improve TMZ release into the brain via nasal delivery. Increasing amounts of poloxamer 407 were added to preformed nanoemulsions (250 nm-range) obtained by spontaneous emulsification...
January 30, 2023: Journal of Controlled Release
#10
JOURNAL ARTICLE
Lucélia Albarello Balestrin, Patrícia Inês Back, Magno da Silva Marques, Gabriela de Moraes Soares Araújo, Mariana Corrêa Falkembach Carrasco, Matheus Monteiro Batista, Tony Silveira, Jamile Lima Rodrigues, Flávia Nathiely Silveira Fachel, Leticia Scherer Koester, Valquiria Linck Bassani, Ana Paula Horn, Cristiana Lima Dora, Helder Ferreira Teixeira
Achyrocline satureioides (Lam.) DC extract-loaded nanoemulsions have demonstrated potential for wound healing, with promising effects on keratinocyte proliferation. We carried out the first in vivo investigation of the wound healing activity of a hydrogel containing A. satureioides extract-loaded nanoemulsions. We prepared hydrogels by adding the gelling agent (Carbopol® Ultrez) to extract-loaded nanoemulsions (~250 nm in diameter) obtained by spontaneous emulsification. The final flavonoid content in formulation was close to 1 mg/mL, as estimated by ultra-fast liquid chromatography...
December 6, 2022: Pharmaceutics
#11
JOURNAL ARTICLE
Katrin J Frank, Antonio Mulero-Sánchez, Alexandra Berninger, Laura Ruiz-Cañas, Astrid Bosma, Kıvanç Görgülü, Nan Wu, Kalliope N Diakopoulos, Ezgi Kaya-Aksoy, Dietrich A Ruess, Derya Kabacaoğlu, Fränze Schmidt, Larissa Kohlmann, Olaf van Tellingen, Bram Thijssen, Marieke van de Ven, Natalie Proost, Susanne Kossatz, Wolfgang A Weber, Bruno Sainz, Rene Bernards, Hana Algül, Marina Lesina, Sara Mainardi
Over 90% of pancreatic cancers present mutations in KRAS, one of the most common oncogenic drivers overall. Currently, most KRAS mutant isoforms cannot be targeted directly. Moreover, targeting single RAS downstream effectors induces adaptive resistance mechanisms. We report here on the combined inhibition of SHP2, upstream of KRAS, using the allosteric inhibitor RMC-4550 and of ERK, downstream of KRAS, using LY3214996. This combination shows synergistic anti-cancer activity in vitro, superior disruption of the MAPK pathway, and increased apoptosis induction compared with single-agent treatments...
November 15, 2022: Cell reports medicine
#12
JOURNAL ARTICLE
Francinne T Tostes, Parisina Fraga Dutra Cabral de Carvalho, Raphael L C Araújo, Rodrigo Chaves Ribeiro, Franz Robert Apodaca-Torrez, Edson José Lobo, Diogo Bugano Diniz Gomes, Donato Callegaro-Filho, Gustavo Schvartsman, Fernando Moura, Vladimir Schraibman, Alberto Goldenberg, Fernanda Teresa de Lima, Vanderlei Segatelli, Pedro Luiz Serrano Uson Junior
Frantz tumors or solid pseudopapillary pancreatic neoplasm (SPN) are rare exocrine neoplasms that carry a favorable prognosis; they represent up to 3% of all tumors located in the region of the pancreas and have specific age and gender predispositions. In recent years, the rising curve of diagnosis is entitled to the evolution and access of diagnostic imaging. In this paper, we have retrospectively reviewed and described the clinical course of 40 patients with SPN from three institutions in Brazil, who had their diagnosis between 2005 and 2020, and analyzed the clinicopathological, genetic, and surgical aspects of these individuals...
October 6, 2022: Genes
#13
REVIEW
Alexander Berndt, Nikolaus Gaßler, Marcus Franz
Invasion of the connective tissue by carcinoma cells is accompanied by disintegration and reorganization of the hemidesmosomes, which connect the basement membrane to the basal epithelial cells. In terms of mediating the basement membrane, i.e., basal cell interactions, the heterotrimeric laminin 332 is the most important bridging molecule. Due to this distinct function, laminin 332, especially its gamma 2 chain, came into the focus of cancer research. Specific de novo synthesis and deposition patterns of laminin 332 are evident upon development and progression of oral squamous cell carcinomas (OSCCs)...
October 7, 2022: Cancers
#14
JOURNAL ARTICLE
Maggie Banys-Paluchowski, Marc Thill, Thorsten Kühn, Nina Ditsch, Jörg Heil, Achim Wöckel, Eva Fallenberg, Michael Friedrich, Sherko Kümmel, Volkmar Müller, Wolfgang Janni, Ute-Susann Albert, Ingo Bauerfeind, Jens-Uwe Blohmer, Wilfried Budach, Peter Dall, Peter Fasching, Tanja Fehm, Oleg Gluz, Nadia Harbeck, Jens Huober, Christian Jackisch, Cornelia Kolberg-Liedtke, Hans H Kreipe, David Krug, Sibylle Loibl, Diana Lüftner, Michael Patrick Lux, Nicolai Maass, Christoph Mundhenke, Ulrike Nitz, Tjoung Won Park-Simon, Toralf Reimer, Kerstin Rhiem, Achim Rody, Marcus Schmidt, Andreas Schneeweiss, Florian Schütz, H Peter Sinn, Christine Solbach, Erich-Franz Solomayer, Elmar Stickeler, Christoph Thomssen, Michael Untch, Isabell Witzel, Bernd Gerber
The recommendations of the AGO Breast Committee on the surgical therapy of breast cancer were last updated in March 2022 (www.ago-online.de). Since surgical therapy is one of several partial steps in the treatment of breast cancer, extensive diagnostic and oncological expertise of a breast surgeon and good interdisciplinary cooperation with diagnostic radiologists is of great importance. The most important changes concern localization techniques, resection margins, axillary management in the neoadjuvant setting and the evaluation of the meshes in reconstructive surgery...
October 2022: Geburtshilfe und Frauenheilkunde
#15
REVIEW
Andrea Frosolini, Leonardo Franz, Antonio Daloiso, Andrea Lovato, Cosimo de Filippis, Gino Marioni
Background and Objectives : Sudden Sensorineural Hearing Loss (SSNHL) is a quite common clinical finding in otolaryngology. Most cases are classified as idiopathic and there is a dearth of information on factors able to predict the response to treatment and hearing recovery. The main aim of this systematic review and meta-analysis was to assess and critically discuss the role of circulating inflammatory biomarkers in SSNHL. Materials and Methods : A search was conducted of the English literature published between 1 January 2009 and 7 July 2022 on Pubmed, Scopus, Web of Science, ScienceDirect, and Cochrane following PRISMA guidelines...
July 20, 2022: Medicina
#16
JOURNAL ARTICLE
Dagmar-Christiane Fischer, Colette Smith, Francesca De Zan, Justine Bacchetta, Sevcan A Bakkaloglu, Ayse Agbas, Ali Anarat, Bilal Aoun, Varvara Askiti, Karolis Azukaitis, Aysun Bayazit, Ipek Kaplan Bulut, Nur Canpolat, Dagmara Borzych-Dużałka, Ali Duzova, Sandra Habbig, Saoussen Krid, Christoph Licht, Mieczyslaw Litwin, Lukasz Obrycki, Fabio Paglialonga, Anja Rahn, Bruno Ranchin, Charlotte Samaille, Mohan Shenoy, Manish D Sinha, Brankica Spasojevic, Constantinos J Stefanidis, Enrico Vidal, Alev Yilmaz, Michel Fischbach, Franz Schaefer, Claus Peter Schmitt, Rukshana Shroff
BACKGROUND: Patients on dialysis have a high burden of bone-related comorbidities, including fractures. We report a post hoc analysis of the prospective cohort study HDF, Hearts and Heights (3H) to determine the prevalence and risk factors for chronic kidney disease-related bone disease in children on hemodiafiltration (HDF) and conventional hemodialysis (HD). METHODS: The baseline cross-sectional analysis included 144 children, of which 103 (61 HD, 42 HDF) completed 12-month follow-up...
September 2021: KI Reports
#17
JOURNAL ARTICLE
Birgit Lohberger, Susanne Scheipl, Ellen Heitzer, Franz Quehenberger, Danielle de Jong, Karoly Szuhai, Bernadette Liegl-Atzwanger, Beate Rinner
Chordomas are rare slow growing, malignant bone tumors of the axial skeleton with no approved medical treatment. As the majority of chordomas express cMET and its ligand, HGF, and crosstalks between EGFR and MET-signaling exist, we aimed to explore cMET activity in chordoma cell lines and clinical samples. We investigated nine chordoma patients and four chordoma cell lines for cMET expression. Two clival and two sacral chordoma cell lines were tested for chromosomal abnormalities of the MET gene locus; we studied the influence of HGF on the autocrine secretion and migration behavior, as well as protein expression and phosphorylation...
June 14, 2021: Scientific Reports
#18
JOURNAL ARTICLE
Stephan Spahn, Daniel Roessler, Radu Pompilia, Gisela Gabernet, Beryl Primrose Gladstone, Marius Horger, Saskia Biskup, Magdalena Feldhahn, Sven Nahnsen, Franz J Hilke, Bernhard Scheiner, Jean-François Dufour, Enrico N De Toni, Matthias Pinter, Nisar P Malek, Michael Bitzer
Immune checkpoint inhibitors (ICIs) belong to the therapeutic armamentarium in advanced hepatocellular carcinoma (HCC). However, only a minority of patients benefit from immunotherapy. Therefore, we aimed to identify indicators of therapy response. This multicenter analysis included 99 HCC patients. Progression-free (PFS) and overall survival (OS) were studied by Kaplan-Meier analyses for clinical parameters using weighted log-rank testing. Next-generation sequencing (NGS) was performed in a subset of 15 patients...
December 18, 2020: Cancers
#19
JOURNAL ARTICLE
María Alejandra Alarcón, Wilda Olivares, Miguel Córdova-Delgado, Matías Muñoz-Medel, Tomas de Mayo, Gonzalo Carrasco-Aviño, Ignacio Wichmann, Natalia Landeros, Julio Amigo, Enrique Norero, Franz Villarroel-Espíndola, Arnoldo Riquelme, Marcelo Garrido, Gareth I Owen, Alejandro H Corvalán
Reprimo-like ( RPRML ) is an uncharacterized member of the Reprimo gene family. Here, we evaluated the role of RPRML and whether its regulation by DNA methylation is a potential non-invasive biomarker of gastric cancer. RPRML expression was evaluated by immunohistochemistry in 90 patients with gastric cancer and associated with clinicopathologic characteristics and outcomes. The role of RPRML in cancer biology was investigated in vitro, through RPRML ectopic overexpression. Functional experiments included colony formation, soft agar, MTS, and Ki67 immunofluorescence assays...
December 12, 2020: International Journal of Molecular Sciences
#20
REVIEW
Giovanni Vitale, Alessandra Dicitore, Luigi Barrea, Emilia Sbardella, Paola Razzore, Severo Campione, Antongiulio Faggiano, Annamaria Colao, Manuela Albertelli, Barbara Altieri, Filomena Bottiglieri, Federica De Cicco, Sergio Di Molfetta, Giuseppe Fanciulli, Tiziana Feola, Diego Ferone, Francesco Ferraù, Marco Gallo, Elisa Giannetta, Federica Grillo, Erika Grossrubatscher, Elia Guadagno, Valentina Guarnotta, Andrea M Isidori, Andrea Lania, Andrea Lenzi, Fabio Lo Calzo, Pasquale Malandrino, Erika Messina, Roberta Modica, Giovanna Muscogiuri, Luca Pes, Genoveffa Pizza, Riccardo Pofi, Giulia Puliani, Carmen Rainone, Laura Rizza, Manila Rubino, Rosa Maria Ruggieri, Franz Sesti, Mary Anna Venneri, Maria Chiara Zatelli
Gut microbiota is represented by different microorganisms that colonize the intestinal tract, mostly the large intestine, such as bacteria, fungi, archaea and viruses. The gut microbial balance has a key role in several functions. It modulates the host's metabolism, maintains the gut barrier integrity, participates in the xenobiotics and drug metabolism, and acts as protection against gastro-intestinal pathogens through the host's immune system modulation. The impaired gut microbiota, called dysbiosis, may be the result of an imbalance in this equilibrium and is linked with different diseases, including cancer...
September 15, 2020: Reviews in Endocrine & Metabolic Disorders
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