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https://www.readbyqxmd.com/read/27438034/solid-pseudopapillary-neoplasm-of-the-pancreas
#1
Jorge Roberto Marcante Carlotto, Franz Robert Apodaca Torrez, Adriano Miziara Gonzalez, Marcelo Moura Linhares, Tarcisio Triviño, Benedito Herani-Filho, Alberto Goldenberg, Gaspar de Jesus Lopes-Filho, Edson José Lobo
BACKGROUND: The solid pseudopapillary neoplasm is a rare tumor of the pancreas. However, it´s etiology still maintain discussions. AIM: To analyze it´s clinical data, diagnosis and treatment. METHODS: A retrospective study of medical records of all patients treated from January 1997 until July 2015. RESULTS: Were identified 17 cases. Most patients were women (94.11%) and the average age was 32.88 years. The main complaint was abdominal mass (47...
April 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27351628/long-term-use-of-everolimus-in-patients-with-tuberous-sclerosis-complex-final-results-from-the-exist-1-study
#2
David N Franz, Elena Belousova, Steven Sparagana, E Martina Bebin, Michael D Frost, Rachel Kuperman, Olaf Witt, Michael H Kohrman, J Robert Flamini, Joyce Y Wu, Paolo Curatolo, Petrus J de Vries, Noah Berkowitz, Julie Niolat, Sergiusz Jóźwiak
BACKGROUND: Everolimus, a mammalian target of rapamycin (mTOR) inhibitor, has demonstrated efficacy in treating subependymal giant cell astrocytomas (SEGAs) and other manifestations of tuberous sclerosis complex (TSC). However, long-term use of mTOR inhibitors might be necessary. This analysis explored long-term efficacy and safety of everolimus from the conclusion of the EXIST-1 study (NCT00789828). METHODS AND FINDINGS: EXIST-1 was an international, prospective, double-blind, placebo-controlled phase 3 trial examining everolimus in patients with new or growing TSC-related SEGA...
2016: PloS One
https://www.readbyqxmd.com/read/27274232/transportan-in-nanocarriers-improves-skin-localization-and-antitumor-activity-of-paclitaxel
#3
Dominique Pepe, Vanessa Fm Carvalho, Melissa McCall, Débora P de Lemos, Luciana B Lopes
In this study, the ability of nanocarriers containing protein transduction domains (PTDs) of various classes to improve cutaneous paclitaxel delivery and efficacy in skin tumor models was evaluated. Microemulsions (MEs) were prepared by mixing a surfactant blend (polyoxyethylene 10 oleoyl ether, ethanol and propylene glycol), monocaprylin, and water. The PTD transportan (ME-T), penetratin (ME-P), or TAT (ME-TAT) was added at a concentration of 1 mM to the plain ME. All MEs displayed nanometric size (32.3-40...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27221950/synthesis-characterization-and-antitumoral-activity-of-new-cobalt-ii-complexes-effect-of-the-ligand-isomerism-on-the-biological-activity-of-the-complexes
#4
Samila R Morcelli, Érika S Bull, Wagner S Terra, Rafaela O Moreira, Franz V Borges, Milton M Kanashiro, Adailton J Bortoluzzi, Leide L F Maciel, João Carlos de A Almeida, Adolfo Horn Júnior, Christiane Fernandes
The synthesis, physico-chemical characterization and cytotoxicity against five human tumoral cell lines (THP-1, U937, Molt-4, Colo205 and H460) of three new cobalt(II) coordination compounds are reported (i.e. Co(HL1)Cl (1), Co(HL2)Cl (2) and [Co(HL3)Cl]0.0.5 (CH3)2CHOH (3)). H2L2 (2-{[[2-hydroxy-3-(1-naphthyloxy)propyl](pyridin-2-ylmethyl)amino]methyl}phenol) and H2L3 (2-{[[2-hydroxy-3-(2-naphthyloxy)propyl](pyridin-2-ylmethyl)amino]methyl}phenol) present α and β-naphthyl groups respectively, which is absent in H2L1 (N-(2-hydroxybenzyl)-N-(2-pyridylmethyl)[(3-chloro)(2-hydroxy)]propylamine...
August 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/26365184/tnf-counterbalances-the-emergence-of-m2-tumor-macrophages
#5
Franz Kratochvill, Geoffrey Neale, Jessica M Haverkamp, Lee-Ann Van de Velde, Amber M Smith, Daisuke Kawauchi, Justina McEvoy, Martine F Roussel, Michael A Dyer, Joseph E Qualls, Peter J Murray
Cancer can involve non-resolving, persistent inflammation where varying numbers of tumor-associated macrophages (TAMs) infiltrate and adopt different activation states between anti-tumor M1 and pro-tumor M2 phenotypes. Here, we resolve a cascade causing differential macrophage phenotypes in the tumor microenvironment. Reduction in TNF mRNA production or loss of type I TNF receptor signaling resulted in a striking pattern of enhanced M2 mRNA expression. M2 gene expression was driven in part by IL-13 from eosinophils co-recruited with inflammatory monocytes, a pathway that was suppressed by TNF...
September 22, 2015: Cell Reports
https://www.readbyqxmd.com/read/26183929/tristetraprolin-limits-inflammatory-cytokine-production-in-tumor-associated-macrophages-in-an-mrna-decay-independent-manner
#6
Franz Kratochvill, Nina Gratz, Joseph E Qualls, Lee-Ann Van De Velde, Hongbo Chi, Pavel Kovarik, Peter J Murray
Tristetraprolin (TTP) is an inducible zinc finger AU-rich RNA-binding protein essential for enforcing degradation of mRNAs encoding inflammatory chemokines and cytokines. Most studies on TTP center on the connection between mRNA half-life and inflammatory output, because loss of TTP amplifies inflammation by increasing the stability of AU-rich mRNAs. Here, we focused on how TTP controls cytokine and chemokine production in the nonresolving inflammation of cancer using tissue-specific approaches. In contrast with model in vitro macrophage systems, we found constitutive TTP expression in late-stage tumor-associated macrophages (TAM)...
August 1, 2015: Cancer Research
https://www.readbyqxmd.com/read/26183213/a-calixpyrrole-derivative-acts-as-an-antagonist-to-gper-a-g-protein-coupled-receptor-mechanisms-and-models
#7
Rosamaria Lappano, Camillo Rosano, Assunta Pisano, Maria Francesca Santolla, Ernestina Marianna De Francesco, Paola De Marco, Vincenza Dolce, Marco Ponassi, Lamberto Felli, Grazia Cafeo, Franz Heinrich Kohnke, Sergio Abonante, Marcello Maggiolini
Estrogens regulate numerous pathophysiological processes, mainly by binding to and activating estrogen receptor (ER)α and ERβ. Increasing amounts of evidence have recently demonstrated that G-protein coupled receptor 30 (GPR30; also known as GPER) is also involved in diverse biological responses to estrogens both in normal and cancer cells. The classical ER and GPER share several features, including the ability to bind to identical compounds; nevertheless, some ligands exhibit opposed activity through these receptors...
October 1, 2015: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/25839161/interleukin-21-sustains-inflammatory-signals-that-contribute-to-sporadic-colon-tumorigenesis
#8
Veronica De Simone, Giulia Ronchetti, Eleonora Franzè, Alfredo Colantoni, Angela Ortenzi, Massimo C Fantini, Angelamaria Rizzo, Giuseppe S Sica, Pierpaolo Sileri, Piero Rossi, Thomas T MacDonald, Francesco Pallone, Giovanni Monteleone, Carmine Stolfi
Interleukin (IL)-21 triggers inflammatory signals that contribute to the growth of neoplastic cells in mouse models of colitis-associated colorectal cancer (CRC). Because most CRCs are sporadic and arise in the absence of overt inflammation we have investigated the role of IL-21 in these tumors in mouse and man. IL-21 was highly expressed in human sporadic CRC and produced mostly by IFN-γ-expressing T-bet/RORγt double-positive CD3+CD8- cells. Stimulation of human CRC cell lines with IL-21 did not directly activate the oncogenic transcription factors STAT3 and NF-kB and did not affect CRC cell proliferation and survival...
April 30, 2015: Oncotarget
https://www.readbyqxmd.com/read/25793577/tenascin-c-and-carcinoma-cell-invasion-in-oral-and-urinary-bladder-cancer
#9
REVIEW
Alexander Berndt, Petra Richter, Hartwig Kosmehl, Marcus Franz
Carcinoma invasion is a complex process regulated by genetic and epigenetic factors as well. A relevant supportive condition for cancer cell migration is the reorganization of the extracellular matrix (ECM), which is realized in an orchestrated multicellular manner including carcinoma cells and stromal fibroblasts. An important key player in the process of ECM reorganization is Tenascin-C (Tn-C). The molecule occurs as different isoforms generated by alternative splicing and de novo glycosylation. Large variants of Tn-C are abundantly re-expressed in the invasive front of many carcinoma types...
2015: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/25608569/panobinostat-reduces-hypoxia-induced-cisplatin-resistance-of-non-small-cell-lung-carcinoma-cells-via-hif-1%C3%AE-destabilization
#10
Carina Fischer, Katharina Leithner, Christoph Wohlkoenig, Franz Quehenberger, Alexandra Bertsch, Andrea Olschewski, Horst Olschewski, Andelko Hrzenjak
BACKGROUND: Lung cancer is one of the most frequent cancer types and the leading cause of cancer death worldwide. Cisplatin is a widely used chemotherapeutic for non-small cell lung carcinoma (NSCLC), however, its positive effects are diminished under hypoxia. We wanted to determine if co-treatment with cisplatin and histone deacetalyse (HDAC) inhibitor panobinostat can reduce hypoxia-induced cisplatin resistance in NSCLC cells, and to elucidate mechanism involved. METHODS: Expression status of different HDACS was determined in two cell lines and in tumor tissue from 20 patients...
January 21, 2015: Molecular Cancer
https://www.readbyqxmd.com/read/25496233/probenecid-as-a-sensitizer-of-bisphosphonate-mediated-effects-in-breast-cancer-cells
#11
Regina Ebert, Jutta Meissner-Weigl, Sabine Zeck, Jorma Määttä, Seppo Auriola, Sofia Coimbra de Sousa, Birgit Mentrup, Stephanie Graser, Tilman D Rachner, Lorenz C Hofbauer, Franz Jakob
BACKGROUND: Anti-resorptive bisphosphonates (BP) are used for the treatment of osteoporosis and bone metastases. Clinical studies indicated a benefit in survival and tumor relapse in subpopulations of breast cancer patients receiving zoledronic acid, thus stimulating the debate about its anti-tumor activity. Amino-bisphosphonates in nM concentrations inhibit farnesyl pyrophosphate synthase leading to accumulation of isopentenyl pyrophosphate (IPP) and the ATP/pyrophosphate adduct ApppI, which induces apoptosis in osteoclasts...
December 11, 2014: Molecular Cancer
https://www.readbyqxmd.com/read/25456370/everolimus-for-subependymal-giant-cell-astrocytoma-in-patients-with-tuberous-sclerosis-complex-2-year-open-label-extension-of-the-randomised-exist-1-study
#12
RANDOMIZED CONTROLLED TRIAL
David Neal Franz, Elena Belousova, Steven Sparagana, E Martina Bebin, Michael Frost, Rachel Kuperman, Olaf Witt, Michael H Kohrman, J Robert Flamini, Joyce Y Wu, Paolo Curatolo, Petrus J de Vries, Noah Berkowitz, Oezlem Anak, Julie Niolat, Sergiusz Jozwiak
BACKGROUND: In the EXIST-1 trial, initiated on Aug 10, 2009, more than 35% of patients with subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex had at least 50% reduction in SEGA volume after 9·6 months of treatment with everolimus. In this Article, we report interim data (up to Jan 11, 2013) to support longer-term tolerability and efficacy of everolimus from the continuing 4-year extension phase of EXIST-1. METHODS: We assessed data from a prospective, open-label extension of a multicentre, phase 3, randomised, double-blind, placebo-controlled study in patients with tuberous sclerosis complex who had SEGA that was growing and needed treatment...
December 2014: Lancet Oncology
https://www.readbyqxmd.com/read/25174402/th17-type-cytokines-il-6-and-tnf-%C3%AE-synergistically-activate-stat3-and-nf-kb-to-promote-colorectal-cancer-cell-growth
#13
V De Simone, E Franzè, G Ronchetti, A Colantoni, M C Fantini, D Di Fusco, G S Sica, P Sileri, T T MacDonald, F Pallone, G Monteleone, C Stolfi
Colorectal cancers (CRCs) often show a dense infiltrate of cytokine-producing immune/inflammatory cells. The exact contribution of each immune cell subset and cytokine in the activation of the intracellular pathways sustaining CRC cell growth is not understood. Herein, we isolate tumor-infiltrating leukocytes (TILs) and lamina propria mononuclear cells (LPMCs) from the tumor area and the macroscopically unaffected, adjacent, colonic mucosa of patients who underwent resection for sporadic CRC and show that the culture supernatants of TILs, but not of LPMCs, potently enhance the growth of human CRC cell lines through the activation of the oncogenic transcription factors signal transducer and activator of transcription 3 (STAT3) and nuclear factor-kappa B (NF-kB)...
July 2015: Oncogene
https://www.readbyqxmd.com/read/24785095/opg-and-pgr-show-similar-cohort-specific-effects-as-prognostic-factors-in-er-positive-breast-cancer
#14
Nicole Sänger, Eugen Ruckhäberle, Giampaolo Bianchini, Tomas Heinrich, Karin Milde-Langosch, Volkmar Müller, Achim Rody, Erich Franz Solomayer, Tanja Fehm, Uwe Holtrich, Sven Becker, Thomas Karn
The RANK/RANKL/OPG pathway is well known for bone destruction in skeletal metastases but has also been implicated in osteoclast-independent roles in tumorigenesis and de novo metastasis. Experimental data suggest contribution of progesterone to tumorigenesis may be mediated by RANKL. Importantly, modulation of this pathway became possible through the availability of denosumab, an artificial counterpart of OPG, but significant gaps remain in the translation of preclinical findings on the pathway. We analyzed gene expression of RANK, RANKL and OPG from 40 Affymetrix datasets encompassing 4467 primary breast cancers and focused on ER positive disease...
October 2014: Molecular Oncology
https://www.readbyqxmd.com/read/24732914/modulation-of-the-chromatin-phosphoproteome-by-the-haspin-protein-kinase
#15
Alessio Maiolica, Maria de Medina-Redondo, Erwin M Schoof, Apirat Chaikuad, Fabrizio Villa, Marco Gatti, Siva Jeganathan, Hua Jane Lou, Karel Novy, Simon Hauri, Umut H Toprak, Franz Herzog, Patrick Meraldi, Lorenza Penengo, Benjamin E Turk, Stefan Knapp, Rune Linding, Ruedi Aebersold
Recent discoveries have highlighted the importance of Haspin kinase activity for the correct positioning of the kinase Aurora B at the centromere. Haspin phosphorylates Thr(3) of the histone H3 (H3), which provides a signal for Aurora B to localize to the centromere of mitotic chromosomes. To date, histone H3 is the only confirmed Haspin substrate. We used a combination of biochemical, pharmacological, and mass spectrometric approaches to study the consequences of Haspin inhibition in mitotic cells. We quantified 3964 phosphorylation sites on chromatin-associated proteins and identified a Haspin protein-protein interaction network...
July 2014: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/24636208/clinical-validity-of-circulating-tumour-cells-in-patients-with-metastatic-breast-cancer-a-pooled-analysis-of-individual-patient-data
#16
MULTICENTER STUDY
François-Clément Bidard, Dieter J Peeters, Tanja Fehm, Franco Nolé, Rafael Gisbert-Criado, Dimitrios Mavroudis, Salvatore Grisanti, Daniele Generali, Jose A Garcia-Saenz, Justin Stebbing, Carlos Caldas, Paola Gazzaniga, Luis Manso, Rita Zamarchi, Angela Fernandez de Lascoiti, Leticia De Mattos-Arruda, Michail Ignatiadis, Ronald Lebofsky, Steven J van Laere, Franziska Meier-Stiegen, Maria-Teresa Sandri, Jose Vidal-Martinez, Eleni Politaki, Francesca Consoli, Alberto Bottini, Eduardo Diaz-Rubio, Jonathan Krell, Sarah-Jane Dawson, Cristina Raimondi, Annemie Rutten, Wolfgang Janni, Elisabetta Munzone, Vicente Carañana, Sofia Agelaki, Camillo Almici, Luc Dirix, Erich-Franz Solomayer, Laura Zorzino, Helene Johannes, Jorge S Reis-Filho, Klaus Pantel, Jean-Yves Pierga, Stefan Michiels
BACKGROUND: We aimed to assess the clinical validity of circulating tumour cell (CTC) quantification for prognostication of patients with metastatic breast cancer by undertaking a pooled analysis of individual patient data. METHODS: We contacted 51 European centres and asked them to provide reported and unreported anonymised data for individual patients with metastatic breast cancer who participated in studies between January, 2003, and July, 2012. Eligible studies had participants starting a new line of therapy, data for progression-free survival or overall survival, or both, and CTC quantification by the CellSearch method at baseline (before start of new treatment)...
April 2014: Lancet Oncology
https://www.readbyqxmd.com/read/24556688/a-functional-role-for-smad7-in-sustaining-colon-cancer-cell-growth-and-survival
#17
C Stolfi, V De Simone, A Colantoni, E Franzè, E Ribichini, M C Fantini, R Caruso, I Monteleone, G S Sica, P Sileri, T T MacDonald, F Pallone, G Monteleone
Initially identified as an inhibitor of transforming growth factor (TGF)-β mainly owing to its ability to bind TGF-β receptor type I and abrogate TGF-β-driven signaling, Smad7 can interact with additional intracellular proteins and regulate TGF-β-independent pathways, thus having a key role in the control of neoplastic processes in various organs. Genome-wide association studies have shown that common alleles of Smad7 influence the risk of colorectal cancer (CRC), even though the contribution of Smad7 in colon carcinogenesis is not fully understood...
February 20, 2014: Cell Death & Disease
https://www.readbyqxmd.com/read/23933562/highly-efficient-synthetic-iron-dependent-nucleases-activate-both-intrinsic-and-extrinsic-apoptotic-death-pathways-in-leukemia-cancer-cells
#18
Adolfo Horn, Christiane Fernandes, Gabrieli L Parrilha, Milton M Kanashiro, Franz V Borges, Edésio J T de Melo, Gerhard Schenk, Hernán Terenzi, Claus T Pich
The nuclease activity and the cytotoxicity toward human leukemia cancer cells of iron complexes, [Fe(HPClNOL)Cl2]NO3 (1), [Cl(HPClNOL)Fe(μ-O)Fe(HPClNOL)Cl]Cl2·2H2O (2), and [(SO4)(HPClNOL)Fe(μ-O)Fe(HPClNOL)(SO4)]·6H2O (3) (HPClNOL=1-(bis-pyridin-2-ylmethyl-amino)-3-chloropropan-2-ol), were investigated. Each complex was able to promote plasmid DNA cleavage and change the supercoiled form of the plasmid to circular and linear ones. Kinetic data revealed that (1), (2) and (3) increase the rate of DNA hydrolysis about 278, 192 and 339 million-fold, respectively...
November 2013: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/23922818/lesional-accumulation-of-cd163-expressing-cells-in-the-gut-of-patients-with-inflammatory-bowel-disease
#19
Eleonora Franzè, Roberta Caruso, Carmine Stolfi, Massimiliano Sarra, Maria Laura Cupi, Flavio Caprioli, Ivan Monteleone, Francesca Zorzi, Daniela De Nitto, Alfredo Colantoni, Livia Biancone, Francesco Pallone, Giovanni Monteleone
Monocytes/macrophages displaying different markers of activation/differentiation infiltrate the inflamed gut of patients with inflammatory bowel diseases (IBD), but the role that each monocyte/macrophage subpopulation plays in the pathogenesis of IBD is not fully understood. The hemoglobin scavenger receptor CD163, a specific marker of monocytes/macrophages, has been associated with either anti-inflammatory or inflammatory functions of macrophages in several pathologies. In this study we examined the tissue distribution and function of CD163-expressing monocytes/macrophages in IBD...
2013: PloS One
https://www.readbyqxmd.com/read/23689408/clinical-and-laboratorial-characterization-and-post-surgical-follow-up-of-87-patients-with-non-functioning-pituitary-macroadenomas
#20
Paulo Andrade de Mello, Luciana Ansaneli Naves, Aldo Pereira Neto, Eduardo Henrique Oliveira, Ivan Coelho Ferreira, Antônio Santos de Araújo Júnior, Franz Jooji Onishi, Luiz Augusto Casulari
OBJECTIVE: It was to assess the main characteristics of patients undergoing pituitary tumor surgery. METHOD: Eighty-seven patients (44 men; 44.8±13 years old) were included. RESULTS: The main symptoms were visual alterations (87.3%), headache (70.1%), diminished libido (34.4%), galactorrhea (22.9%) and hair loss (19.5%). The axes affected were gonadotropic (72.6%), thyrotropic (48.4%) and corticotropic (38.7%), without significant changes after surgery...
May 2013: Arquivos de Neuro-psiquiatria
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