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skin diseases in geriatric population

Hammad Ullah, Haroon Khan
Parkinson's disease (PD) involves aggregation of α-synuclein and progressive loss of dopaminergic neurons. Pathogenesis of PD may also be related to one's genetic background. PD is most common among geriatric population and approximately 1-2% of population suffers over age 65 years. Currently no successful therapies are in practice for the management of PD and available therapies tend to decrease the symptoms of PD only. Furthermore, these are associated with diverse range of adverse effects profile. The neuroprotective effects of polyphenols are widely studied and documented...
2018: Frontiers in Pharmacology
Laura Buford, Rebecca Kaiser, Vesna Petronic-Rosic
Aging results in both anatomic and physiologic changes in the skin's structure and vascular system. These vascular changes result in a wide array of dermatologic findings, ranging from the benign to the highly morbid. Herein, we review the impact of both intrinsic and common extrinsic factors of aging on cutaneous vasculature and highlight the manifestations of microvascular, venous, arterial, lymphatic, and neuropathic alterations in the geriatric population.
March 2018: Clinics in Dermatology
Alina Shevchenko, Rodrigo Valdes-Rodriguez, Gil Yosipovitch
Chronic itch is a common and debilitating health condition in the elderly. There are several common causes of itch in the mature population, such as skin xerosis, immunosenescence, and neuropathic changes. In addition, skin diseases, such as seborrheic dermatitis and stasis dermatitis, systemic conditions (end-stage renal disease and diabetes), or psychogenic derailments, such as depression, anxiety, and dementia, can all serve as triggers of pruritus. Polypharmacy, a common occurrence among the elderly population, may also serve as a cause of itch that may or may not be accompanied by dermatitis...
March 2018: Clinics in Dermatology
Elisabeth Hahnel, Ulrike Blume-Peytavi, Carina Trojahn, Jan Kottner
BACKGROUND: Geriatric patients are affected by a range of skin conditions and dermatological diseases, functional limitations and chronic diseases. Skin problems are highly prevalent in elderly populations. Aim of this study was to investigate possible associations between health, functional and cutaneous variables in aged long-term care residents. METHODS: This observational, cross-sectional, descriptive prevalence study was conducted in a random sample of 10 institutional long-term care facilities in Berlin...
November 13, 2017: BMC Geriatrics
Simone Garcovich, Giuseppe Colloca, Pietro Sollena, Bellieni Andrea, Lodovico Balducci, William C Cho, Roberto Bernabei, Ketty Peris
Skin cancer is a worldwide, emerging clinical need in the elderly white population, with a steady increase in incidence rates, morbidity and related medical costs. Skin cancer is a heterogeneous group of cancers comprising cutaneous melanoma and non-melanoma skin cancers (NMSC), which predominantly affect elderly patients, aged older than 65 years. Melanoma has distinct clinical presentations in the elderly patient and represents a challenging question in terms of clinical management. NMSC includes the basal cell carcinoma and cutaneous squamous cell carcinoma and presents a wide disease spectrum in the elderly population, ranging from low-risk to high-risk tumours, advanced and inoperable disease...
October 2017: Aging and Disease
José-Alcides de Arruda, Pedro Silva, Márcio-Bruno Amaral, Fernanda Cotta, Renata Avendanho, Ricardo Mesquita
Erythema multiforme is an uncommon acute inflammatory disorder caused by exposure to microbes or drugs. Erythema multiforme minor typically affects only one mucosa and can be associated with symmetrical target skin lesions on the extremities. The disease usually occurs in patients in their 3rd and 4th decade of life, but can also affect children and adolescents. Alendronate sodium has been approved for the prevention and treatment of osteoporosis in postmenopausal women, but is associated with adverse events...
July 2017: Journal of Clinical and Experimental Dentistry
Scharukh Jalisi, Samuel J Rubin, Kevin Y Wu, Diana N Kirke
OBJECTIVES/HYPOTHESIS: Evaluate the impact of case volume and other variables on cost and mortality after head and neck oncologic surgery in the geriatric population. STUDY DESIGN: Cross-sectional study. METHODS: The Vizient database was accessed for data on geriatric patients (age ≥65 years) who underwent surgery for head and neck cancers (excluding thyroid and skin cancer) at full member academic medical centers between 2009 and 2012. Multivariate, linear regression analyses, χ2 tests, and analysis of variance were applied to evaluate significant associations between hospital case volume and independent variables including cost, cost index, mortality, mortality index, length of stay, length of stay index, and readmission rates...
November 2017: Laryngoscope
E Makrantonaki, E Steinhagen-Thiessen, R Nieczaj, C C Zouboulis, R Eckardt
BACKGROUND: Improvement of quality of life in old age and prevention of age-associated diseases have become the main focus of research into aging; however, information regarding the skin health status of geriatric patients still remains sparse. GOAL: To investigate the extent of dermatological diseases in hospitalized geriatric patients, map the most prevalent ones, check for any gender differences and document any correlations with duration of hospitalization and results of geriatric assessments...
August 2017: Zeitschrift Für Gerontologie und Geriatrie
Rashmi Jindal, Akanksha Jain, Samarjit Roy, S D S Rawat, Nancy Bhardwaj
INTRODUCTION: Ageing results in decline of normal functioning in all organ systems including skin. This predisposes the elderly persons to develop various skin ailments. A thorough knowledge of different diseases prevalent in this population in different geographic regions help the health care providers in better health care policy making. AIM: This study was planned to know the common dermatological diseases prevalent in Uttarakhand region of India. MATERIALS AND METHODS: Hospital out patients records maintained in Department of Dermatology, Venereology & Leprosy were analysed and information regarding age, sex and diagnosis of patients were recorded...
March 2016: Journal of Clinical and Diagnostic Research: JCDR
Ryoji Tanei, Yasuko Hasegawa
Atopic dermatitis (AD) in older adults represents a newly defined subgroup of AD. The prevalence of elderly AD is approximately 1-3% among elderly populations in industrialized countries. Elderly patients with AD show some common clinical characteristics, such as a male predominance, a lower incidence of lichenified eczema at the elbow and knee folds, and particular patterns of onset and clinical course. Both immunoglobulin (Ig)E-allergic and non-IgE-allergic types are observed in elderly AD. Elderly patients with IgE-allergic AD show high rates of positivity for specific IgE antibodies against house dust mites, associations with IgE allergic and asthmatic complications, histopathological features with a predominance of IgE-mediated allergic inflammation in the lesional skin, and a significantly lower incidence of malignancy as compared with control subjects...
March 2016: Geriatrics & Gerontology International
Philippe Humbert, Brigitte Dréno, Jean Krutmann, Thomas Anton Luger, Raoul Triller, Sylvie Meaume, Sophie Seité
The increasingly aged population worldwide means more people are living with chronic diseases, reduced autonomy, and taking various medications. Health professionals should take these into consideration when managing dermatological problems in elderly patients. Accordingly, current research is investigating the dermatological problems associated with the loss of cutaneous function with age. As cell renewal slows, the physical and chemical barrier function declines, cutaneous permeability increases, and the skin becomes increasingly vulnerable to external factors...
2016: Clinical Interventions in Aging
Muhterem Polat, Mustafa N İlhan
The geriatric population is continuously growing, which leads to more aged patients being admitted to dermatology clinics. The aim of this study is to determine the dermatological complaints of the elderly attending a dermatology outpatient clinic. All of the patients aged 65 years and older admitted to our dermatology outpatient clinic over a 1-year period were included. Patients were divided into 2 groups according to their ages as group I (65-74 years) and group II (≥75 years). The patients were asked about their dermatologic complaints...
2015: Acta Dermatovenerologica Croatica: ADC
Pulak R Manna, Cloyce L Stetson, Andrzej T Slominski, Kevin Pruitt
Steroid hormones are an important class of regulatory molecules that are synthesized in steroidogenic cells of the adrenal, ovary, testis, placenta, brain, and skin, and influence a spectrum of developmental and physiological processes. The steroidogenic acute regulatory protein (STAR) predominantly mediates the rate-limiting step in steroid biosynthesis, i.e., the transport of the substrate of all steroid hormones, cholesterol, from the outer to the inner mitochondrial membrane. At the inner membrane, cytochrome P450 cholesterol side chain cleavage enzyme cleaves the cholesterol side chain to form the first steroid, pregnenolone, which is converted by a series of enzymes to various steroid hormones in specific tissues...
January 2016: Endocrine
Radomir Reszke, Dorota Pełka, Angela Walasek, Zbigniew Machaj, Adam Reich
BACKGROUND: Skin problems in the elderly population have rarely been the subject of scientific research. OBJECTIVES: The present study aimed to determine the prevalences of the most common dermatological conditions in elderly subjects and to investigate their associations with systemic diseases. METHODS: The study involved a group of 198 consecutive patients aged ≥ 65 years who were admitted to the Departments of Dermatology and Geriatrics at the study institution...
September 2015: International Journal of Dermatology
Amit S Chitnis, Katherine Robsky, Gisela F Schecter, Janice Westenhouse, Pennan M Barry
OBJECTIVES: To examine trends in tuberculosis (TB) incidence and to compare demographic and clinical characteristics of nursing home (NH) residents and community-dwelling older adults. DESIGN: Prospective TB surveillance. SETTING: TB cases reported in California from 2000 to 2009. PARTICIPANTS: TB patients aged 65 and older. MEASUREMENTS: Trends in TB incidence per 100,000 population were assessed using Poisson regression...
June 2015: Journal of the American Geriatrics Society
Franca Marangoni, Giovanni Corsello, Claudio Cricelli, Nicola Ferrara, Andrea Ghiselli, Lucio Lucchin, Andrea Poli
The relationship between the consumption of meat and health is multifaceted, and it needs to be analyzed in detail, with specific attention to the relevant differences that characterize the effects of the different meat types, as yet considered by only a limited literature. A variable but moderate energy content, highly digestible proteins (with low levels of collagen) of good nutritional quality, unsaturated lipids (mainly found in the skin and easily removed), B-group vitamins (mainly thiamin, vitamin B6, and pantothenic acid), and minerals (like iron, zinc, and copper) make poultry meat a valuable food...
2015: Food & Nutrition Research
Melissa J Danesh, Anne Lynn S Chang
The National Research Council of the National Academies defines elder mistreatment as: (1) intentional actions that cause harm or create serious risk of harm (whether or not harm is intended) to a vulnerable elder by a caregiver or other person who stands in a trust relationship to the elder; or (2) failure by a caregiver to satisfy the elder's basic needs or to protect the elder from harm. Estimates of the prevalence of elder abuse have ranged from 2.2% to 18.4%. Dermatologists are uniquely positioned to identify and manage suspected cases of elder abuse given their expertise in distinguishing skin lesions of abuse from organic medical disease and their patient populations with strong elderly representation...
August 2015: Journal of the American Academy of Dermatology
Pragya A Nair, Rita Vora
INTRODUCTION: Aging population is susceptible to many cutaneous and systemic diseases, simultaneously leading to impairment of quality of life in them. AIM: To know the association of dermatosis and systemic diseases in geriatric age group. MATERIALS AND METHODS: A retrospective study was carried on patients above 60 years of age who visited the Dermatology OPD at rural tertiary care centre from June 2009 to May 2010. Patients were assessed on a prescribed 30 point proforma...
January 2015: Journal of Family Medicine and Primary Care
J A Gerdin, S P McDonough, R Reisman, J Scarlett
The authors reviewed the case circumstances, population characteristics, gross, and histopathologic findings in 40 cases of emaciated dogs with a suspected diagnosis of starvation. The dogs' estimated age ranged from 3 months to geriatric. Nineteen breeds were represented, including small-breed (n = 11), large-breed (n = 13), and pit bull-type (n = 16) dogs. The median body condition score was 1 out of 9 (Purina scale). Various diseases were identified as the cause of death in 7 dogs, while the cause of death in the other 33 dogs was starvation due to exogenous causes (SEC)...
September 2016: Veterinary Pathology
David G Greenhalgh
Aging has significant effects on the healing ability of the geriatric population. When the elderly suffer injuries, they have a decreased metabolic reserve to handle the stress required to recover. Diseases of the elderly, such as malnutrition, diabetes mellitus, treatment of malignancies, and vascular disease, all impair tissue repair. The geriatric population is more prone to pressure ulcers, venous stasis ulcers, and other chronic wounds. This review discusses how changes in the elderly lead to impaired healing or chronic wounds...
February 2015: Surgical Clinics of North America
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