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https://www.readbyqxmd.com/read/28319001/impact-on-psychosocial-outcomes-of-a-nationally-available-weight-management-program-tailored-for-individuals-with-type-2-diabetes-results-of-a-randomized-controlled-trial
#1
Lauren Holland-Carter, Peter W Tuerk, Thomas A Wadden, Ken N Fujioka, Lynne E Becker, Karen Miller-Kovach, Priscilla L Hollander, W Timothy Garvey, Daniel Weiss, Domenica M Rubino, Robert F Kushner, Robert J Malcolm, William J Raum, Kathie L Hermayer, Jan L Veliko, Stephanie L Rost, Nicoleta D Sora, Jonny L Salyer, Patrick M O'Neil
AIMS: Type 2 diabetes mellitus (T2DM) can substantially decrease quality of life (QOL). This study examined the effects on QOL-relevant psychosocial measures of a widely available commercial weight loss program enhanced for individuals with T2DM. METHODS: A year-long multi-site randomized clinical trial compared the Weight Watchers (WW) approach, supplemented with phone and email counseling with a certified diabetes educator (CDE), to brief standard diabetes nutrition counseling and education (Standard Care; SC)...
February 16, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28318404/magnetization-transfer-imaging-of-treatment-resistant-depression
#2
Zhiyun Jia, Wei Peng, Ziqi Chen, Huaiqiang Sun, Huawei Zhang, Weihong Kuang, Xiaoqi Huang, Su Lui, Qiyong Gong
Purpose To detect biophysical abnormalities in patients with postmedication treatment-resistant depression (TRD) with magnetization transfer imaging. Materials and Methods This study was approved by the local ethics committee, and written informed consent was obtained from all participants. Participants included 69 patients with major depressive disorder (MDD) (30 with TRD; 39 with non-TRD) and 41 healthy control subjects. Age and sex were examined with one-way analysis of variance and χ(2) tests and were well matched among the three groups...
March 17, 2017: Radiology
https://www.readbyqxmd.com/read/28303261/long-lasting-visuo-vestibular-mismatch-in-freely-behaving-mice-reduces-the-vestibulo-ocular-reflex-and-leads-to-neural-changes-in-the-direct-vestibular-pathway
#3
Julie Carcaud, Filipa França de Barros, Erwin Idoux, Daniel Eugène, Lionel Reveret, Lee E Moore, Pierre-Paul Vidal, Mathieu Beraneck
Calibration of the vestibulo-ocular reflex (VOR) depends on the presence of visual feedback. However, the cellular mechanisms associated with VOR modifications at the level of the brainstem remain largely unknown. A new protocol was designed to expose freely behaving mice to a visuo-vestibular mismatch during a 2-week period. This protocol induced a 50% reduction of the VOR. In vivo pharmacological experiments demonstrated that the VOR reduction depends on changes located outside the flocculus/paraflocculus complex...
January 2017: ENeuro
https://www.readbyqxmd.com/read/28302152/myocardial-susceptibility-to-ischaemia-reperfusion-in-obesity-a-re-evaluation-of-the-effects-of-age
#4
I Webster, R Salie, E Marais, W-J Fan, G Maarman, B Huisamen, A Lochner
BACKGROUND: Reports on the effect of age and obesity on myocardial ischaemia/reperfusion (I/R) injury and ischaemic preconditioning are contradictory. The aim of this study was to re-evaluate the effects of age and diet-induced obesity (DIO) on myocardial I/R injury and preconditioning potential. METHODS: Four groups of Wistar male rats were used: age-matched controls (AMC) receiving standard rat chow for (i) 16 weeks and (ii) 16 months respectively; DIO rats receiving a sucrose-supplemented diet for (iii) 16 weeks and (iv) 16 months respectively...
March 17, 2017: BMC Physiology
https://www.readbyqxmd.com/read/28298787/caudal-levobupivacaine-supplemented-with-caudal-or-intravenous-clonidine-in-children-undergoing-infraumbilical-surgery-a-randomized-prospective-double-blind-study
#5
Laxmi Ramya Potti, Yatish Bevinaguddaiah, S Archana, Vinayak Seenappa Pujari, C Manjunath Abloodu
BACKGROUND: Caudal analgesia is the most popular regional anesthesia technique in pediatric population for intraoperative and postoperative analgesia. Clonidine, an α2 agonist, prolongs analgesia without causing significant respiratory depression after systemic or neuraxial administration. However, the most beneficial route of its administration is still controversial. Thus, we compared the effects of caudal and intravenous (i.v) clonidine on postoperative analgesia produced by caudal levobupivacaine in children undergoing infraumbilical surgery...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28294985/effects-of-a-diet-based-weight-reducing-program-with-probiotic-supplementation-on-satiety-efficiency-eating-behaviour-traits-and-psychosocial-behaviours-in-obese-individuals
#6
Marina Sanchez, Christian Darimont, Shirin Panahi, Vicky Drapeau, André Marette, Valerie H Taylor, Jean Doré, Angelo Tremblay
This study evaluated the impact of probiotic supplementation (Lactobacillus rhamnosus CGMCC1.3724 (LPR)) on appetite sensations and eating behaviors in the context of a weight-reducing program. Obese men (n = 45) and women (n = 60) participated in a double-blind, randomized, placebo-controlled trial that included a 12-week weight loss period (Phase 1) based on moderate energy restriction, followed by 12 weeks of weight maintenance (Phase 2). During the two phases of the program, each subject consumed two capsules per day of either a placebo or a LPR formulation (10 mg of LPR equivalent to 1...
March 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28294068/cognitive-impacts-of-estrogen-treatment-in-androgen-deprived-males-what-needs-to-be-resolved
#7
Erik Wibowo
BACKGROUND: Many prostate cancer (PCa) patients are on androgen deprivation therapy (ADT) as part of their cancer treatments but ADT may cause cognitive impairments. ADT depletes men of both androgen and estrogen. Whether estradiol supplementation can improve cognitive impairments in patients on ADT is understudied. OBJECTIVE: To summarize data on the effects of estradiol treatment on cognitive function of androgen-deprived genetic male populations (PCa patients and male-to-female transsexuals) and castrated male animals...
March 13, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28289280/biochemical-physiological-and-clinical-effects-of-l-methylfolate-in-schizophrenia-a-randomized-controlled-trial
#8
J L Roffman, L J Petruzzi, A S Tanner, H E Brown, H Eryilmaz, N F Ho, M Giegold, N J Silverstein, T Bottiglieri, D S Manoach, J W Smoller, D C Henderson, D C Goff
Folic acid supplementation confers modest benefit in schizophrenia, but its effectiveness is influenced by common genetic variants in the folate pathway that hinder conversion to its active form. We examined physiological and clinical effects of l-methylfolate, the fully reduced and bioactive form of folate, in schizophrenia. In this randomized, double-blind trial, outpatients with schizophrenia (n=55) received l-methylfolate 15 mg or placebo for 12 weeks. Patients were maintained on stable doses of antipsychotic medications...
March 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28289215/selective-dietary-supplementation-in-early-postpartum-is-associated-with-high-resilience-against-depressed-mood
#9
Yekta Dowlati, Arun V Ravindran, Zindel V Segal, Donna E Stewart, Meir Steiner, Jeffrey H Meyer
Medical research is moving toward prevention strategies during prodromal states. Postpartum blues (PPB) is often a prodromal state for postpartum depression (PPD), with severe PPB strongly associated with an elevated risk for PPD. The most common complication of childbearing, PPD has a prevalence of 13%, but there are no widespread prevention strategies, and no nutraceutical interventions have been developed. To counter the effects of the 40% increase in monoamine oxidase A (MAO-A) levels that occurs during PPB, a dietary supplement kit consisting of monoamine precursor amino acids and dietary antioxidants was created...
March 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28288438/epidemiology-of-pharmaceutically-treated-depression-and-treatment-resistant-depression-in-taiwan
#10
Daniel Fife, Yu Feng, Michael Yao-Hsien Wang, Chee-Jen Chang, Chia-Yih Liu, Hsiao-Ting Juang, Wesley Furnback, Jaskaran Singh, Bruce Wang
Epidemiologic data on treatment resistant depression (TRD) in Asia-Pacific countries are limited. We estimated the incidence of TRD in Taiwan using a cohort of 704,265 adults randomly sampled from Taiwan's National Health Insurance Research database for 2005. TRD was defined as a patient having pharmaceutically treated depression (PTD) not adequately responding to 2 antidepressant (AD) regimens, i.e., AD regimens that were followed by other AD regimens. Among 2751 PTD subjects, 576 (20.94%, 95% CI: 19.46, 22...
March 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28283824/prospective-association-between-adherence-to-the-mediterranean-diet-and-risk-of-depressive-symptoms-in-the-french-su-vi-max-cohort
#11
Moufidath Adjibade, Karen E Assmann, Valentina A Andreeva, Cédric Lemogne, Serge Hercberg, Pilar Galan, Emmanuelle Kesse-Guyot
PURPOSE: This study examines whether adherence to the Mediterranean Diet (MD) measured by several dietary indexes was associated with incident depressive symptoms in a large French cohort. METHODS: The study sample consisted of 3523 participants from the Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) cohort who had at least three dietary records at baseline during the first 2 years of follow-up (1994-1996), free of depression at the beginning of the study (1996-1997) and available Center for Epidemiologic Studies Depression Scale (CES-D) data at the end of follow-up (2007-2009)...
March 10, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28279394/validation-and-application-of-the-chinese-version-of-the-10-item-connor-davidson-resilience-scale-cd-risc-10-among-parents-of-children-with-cancer-diagnosis
#12
Zeng Jie Ye, Hong Zhong Qiu, Peng Fei Li, Peng Chen, Mu Zi Liang, Mei Ling Liu, Yuan Liang Yu, Shu Ni Wang, Xiao Ming Quan
PURPOSE: Parents of children diagnosed with cancer often experience considerable emotional distress for their children with negative emotions, such as disbelief, depression, anxiety, hope and shock. Resilience is defined as the psychological characteristics that promote positive adaptation in the face of stress and adversity, which has been demonstrated to relate to positive coping and less psychological distress. Thus, a quick screening tool to evaluate the levels of resilience of parents with cancer-diagnosed children is urgently required...
April 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/28278598/transactional-associations-among-maternal-depression-parent-child-coercion-and-child-conduct-problems-during-early-childhood
#13
Katherine A Hails, Julia D Reuben, Daniel S Shaw, Thomas J Dishion, Melvin N Wilson
Maternal depression is among the most consistent and well-replicated risk factors for negative child outcomes, particularly in early childhood. Although children of depressed mothers are at an increased risk of adjustment problems, conversely, children with emotional or behavioral problems also have been found to adversely compromise maternal functioning, including increasing maternal depression. The purpose of this investigation was to examine transactional associations among maternal depression, parent-child coercive interaction, and children's conduct and emotional problems in early childhood using a cross-lagged panel model...
February 26, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28277138/oral-carnitine-supplementation-influences-mental-health-parameters-and-biomarkers-of-oxidative-stress-in-women-with-polycystic-ovary-syndrome-a-randomized-double-blind-placebo-controlled-trial
#14
Hamidreza Jamilian, Mehri Jamilian, Mansooreh Samimi, Faraneh Afshar Ebrahimi, Maryam Rahimi, Fereshteh Bahmani, Sama Aghababayan, Mobina Kouhi, Sedighe Shahabbaspour, Zatollah Asemi
INTRODUCTION: Limited data are available assessing the effects of oral carnitine supplementation on mental health parameters and biomarkers of oxidative stress of women with polycystic ovary syndrome (PCOS).This study was designed to determine the effects of oral carnitine supplementation on mental health parameters and biomarkers of oxidative stress in women with PCOS. METHODS: In the current randomized, double-blind, placebo-controlled trial, 60 patients diagnosed with PCOS were randomized to take either 250 mg carnitine supplements (n = 30) or placebo (n = 30) for 12 weeks...
February 21, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28271656/biological-activity-and-toxicity-of-the-chinese-herb-magnolia-officinalis-rehder-e-wilson-houpo-and-its-constituents
#15
Mélanie Poivre, Pierre Duez
Traditional Chinese herbal drugs have been used for thousands of years in Chinese pharmacopoeia. The bark of Magnolia officinalis Rehder & E. Wilson, known under the pinyin name "Houpo", has been traditionally used in Chinese and Japanese medicines for the treatment of anxiety, asthma, depression, gastrointestinal disorders, headache, and more. Moreover, Magnolia bark extract is a major constituent of currently marketed dietary supplements and cosmetic products. Much pharmacological activity has been reported for this herb and its major compounds, notably antioxidant, anti-inflammatory, antibiotic and antispasmodic effects...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28270033/influence-of-serum-25-hydroxyvitamin-d-on-the-rate-of-pain-episodes-in-nigerian-children-with-sickle-cell-anaemia
#16
Samuel Ademola Adegoke, Oyeku Akibu Oyelami, Adekunle Adekile, Maria Stella Figueiredo
BACKGROUND: In sickle cell disease (SCD), symptoms of vitamin D deficiency (VDD) and chronic pain can overlap. AIM: To examine the relationship between serum vitamin D levels and the frequency of acute pain episodes. METHODS: In this cross-sectional study, serum 25-hydroxyvitamin D (25-OHD) was assayed by high-performance liquid chromatography, and its influence on the number of significant pain episodes was examined by bivariate and logistic regression analyses...
March 8, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28266612/microbiota-alteration-is-associated-with-the-development-of-stress-induced-despair-behavior
#17
Ioana A Marin, Jennifer E Goertz, Tiantian Ren, Stephen S Rich, Suna Onengut-Gumuscu, Emily Farber, Martin Wu, Christopher C Overall, Jonathan Kipnis, Alban Gaultier
Depressive disorders often run in families, which, in addition to the genetic component, may point to the microbiome as a causative agent. Here, we employed a combination of behavioral, molecular and computational techniques to test the role of the microbiota in mediating despair behavior. In chronically stressed mice displaying despair behavior, we found that the microbiota composition and the metabolic signature dramatically change. Specifically, we observed reduced Lactobacillus and increased circulating kynurenine levels as the most prominent changes in stressed mice...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28259401/replacing-alfalfa-silage-with-tannin-containing-birdsfoot-trefoil-silage-in-total-mixed-rations-for-lactating-dairy-cows
#18
G A Broderick, J H Grabber, R E Muck, U C Hymes-Fecht
Two lactation trials were conducted comparing the feeding value of silages made from birdsfoot trefoil (BFT, Lotus corniculatus L.) that had been selected for low (BFTL), medium (BFTM), and high (BFTH) levels of condensed tannins (CT) to an alfalfa silage (AS) when fed as the principal forage in total mixed rations. Diets also included corn silage, high-moisture shelled corn, soybean meal, soy hulls, and supplemental fat. In trial 1, 32 lactating Holstein cows were blocked by days in milk, assigned to treatment sequences in 8 balanced 4 × 4 Latin squares, and fed 50% dietary dry matter from AS or 1 of 3 BFT silages containing 0...
March 2, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28252882/effectiveness-of-supplementary-cognitive-behavioral-therapy-for-pharmacotherapy-resistant-depression-a-randomized-controlled-trial
#19
Atsuo Nakagawa, Dai Mitsuda, Mitsuhiro Sado, Takayuki Abe, Daisuke Fujisawa, Toshiaki Kikuchi, Satoru Iwashita, Masaru Mimura, Yutaka Ono
OBJECTIVE: Antidepressant medication is efficacious in the treatment of depression, but not all patients improve with antidepressant medication alone. Despite this treatment gap, limited evidence regarding the effectiveness of supplementing psychotherapy for pharmacotherapy-resistant depression is available. Therefore, we investigated the effectiveness of supplementing usual medication management (treatment as usual [TAU]) with cognitive-behavioral therapy (CBT) in patients with pharmacotherapy-resistant depression seeking psychiatric specialty care...
February 28, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28241991/effect-of-magnesium-supplementation-on-depression-status-in-depressed-patients-with-magnesium-deficiency-a-randomized-double-blind-placebo-controlled-trial
#20
Afsaneh Rajizadeh, Hassan Mozaffari-Khosravi, Mojtaba Yassini-Ardakani, Ali Dehghani
OBJECTIVES: The aim of this study was to determine the effect of magnesium supplementation on the depression status of depressed patients suffering from magnesium deficiency. METHODS: Sixty depressed people suffering from hypomagnesemia participated in this trial. The individuals were randomly categorized into two groups of 30 members; one receiving two 250-mg tablets of magnesium oxide (MG) daily and the other receiving placebo (PG) for 8 wk. The Beck Depression Inventory-II was conducted and the concentration of serum magnesium was measured...
March 2017: Nutrition
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