Penghong Liu, Zhifen Liu, Jizhi Wang, Junyan Wang, Mingxue Gao, Yanyan Zhang, Chunxia Yang, Aixia Zhang, Gaizhi Li, Xinrong Li, Sha Liu, Lixin Liu, Ning Sun, Kerang Zhang
Inflammatory depression is a treatment-resistant subtype of depression. A causal role of the gut microbiota as a source of low-grade inflammation remains unclear. Here, as part of an observational trial, we first analyze the gut microbiota composition in the stool, inflammatory factors and short-chain fatty acids (SCFAs) in plasma, and inflammatory and permeability markers in the intestinal mucosa of patients with inflammatory depression (ChiCTR1900025175). Gut microbiota of patients with inflammatory depression exhibits higher Bacteroides and lower Clostridium, with an increase in SCFA-producing species with abnormal butanoate metabolism...
April 8, 2024: Nature Communications