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https://www.readbyqxmd.com/read/28938155/nickel-accumulation-by-the-green-algae-like-euglena-gracilis
#1
J D García-García, K A Peña-Sanabria, R Sánchez-Thomas, R Moreno-Sánchez
Nickel accumulation and nickel effects on cellular growth, respiration, photosynthesis, ascorbate peroxidase (APX) activity, and levels of thiols, histidine and phosphate-molecules were determined in Euglena gracilis. Cells incubated with 0.5-1mM NiCl2 showed impairment of O2 consumption, photosynthesis, Chl a+b content and APX activity whereas cellular integrity and viability were unaltered. Nickel accumulation was depressed by Mg(2+) and Cu(2+), while Ca(2+), Co(2+), Mn(2+) and Zn(2+) were innocuous. The growth half-inhibitory concentrations for Ni(2+) in the culture medium supplemented with 2 or 0...
September 7, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28936936/-treatment-of-dementia
#2
K Blom, G A H van den Elsen, H L Koek, J B Sanders, H C Kruithof, J A H R Claassen
- Treatment options for patients with dementia are limited. This article provides an overview of possible interventions, both pharmaceutical and non-pharmaceutical, for Alzheimer's disease, vascular dementia and mixed dementia.- Pharmaceutical treatment options include cholinesterase inhibitors, memantine and experimental medication. Cholinesterase inhibitors are only recommended for Alzheimer's disease and mixed dementia, not for vascular dementia or mild cognitive impairment. There is no proof of effectiveness for the other pharmaceutical options...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28932258/the-effect-for-japanese-workers-of-a-self-help-computerized-cognitive-behaviour-therapy-program-with-a-supplement-soft-drink
#3
Kentaro Shirotsuki, Yuji Nonaka, Keiichi Abe, So-Ichiro Adachi, Shohei Adachi, Tomifusa Kuboki, Mutsuhiro Nakao
BACKGROUND: Computerized cognitive behaviour therapy (CCBT) programs can provide a useful self-help approach to the treatment of psychological problems. Previous studies have shown that CCBT has moderate effects on depression, insomnia, and anxiety. The present study investigated whether a supplement drink that includes L-carnosine enhances the effect of CCBT on psychological well-being. METHODS: Eighty-seven participants were randomly allocated to a control group, CCBT, or CCBT with supplement drink...
2017: BioPsychoSocial Medicine
https://www.readbyqxmd.com/read/28931777/antidepressant-like-effect-of-milk-derived-lactoferrin-in-the-repeated-forced-swim-stress-mouse-model
#4
Takashi Takeuchi, Kana Matsunaga, Akihiko Sugiyama
We investigated the antidepressant-like effect of lactoferrin (Lf) in a repeated forced-swim test (FST) stress mouse model. FST was performed on days 1, 2, 7 and 14. Bovine Lf (bLf) or bovine serum albumin (BSA) was supplemented at 1% to the commercial diet after the first FST throughout the experimental period. The FST-control and FST+BSA group showed a marked increase in immobility time on day 2, which remained increased up to the 14th day, while the FST+bLf group showed a significant lower immobility time...
September 21, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28930059/the-role-of-alcohol-on-antiretroviral-therapy-adherence-among-persons-living-with-hiv-in-urban-india
#5
Stephen L Schensul, Toan Ha, Jean J Schensul, Melita Vaz, Rajendra Singh, Joseph A Burleson, Kendall Bryant
OBJECTIVE: The purpose of this study was to estimate the prevalence of alcohol use among men living with HIV on antiretroviral therapy (ART) and examine the association of alcohol use and psychosocial variables on ART adherence. The study was a cross-sectional survey supplemented by medical records and qualitative narratives as a part of the initial formative stage of a multilevel, multicentric intervention and evaluation project. METHOD: A screening instrument was administered to men living with HIV (n = 3,088) at four ART Centers using the Alcohol Use Disorders Identification Test-consumption questions (AUDIT-C) to determine alcohol use for study eligibility...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28922729/lithium-induced-oxidative-damage-and-inflammation-in-the-rat-s-heart-protective-effect-of-grape-seed-and-skin-extract
#6
Ali Mezni, Hanène Aoua, Olfa Khazri, Ferid Limam, Ezzeddine Aouani
Lithium (Li) is a relevant mood stabilizer metal for the treatment of bipolar disorder (BD), as it protects from both depression and mania and reduces the risk of suicide. However, Lihas some clinical concerns as a narrow therapeutic index requiring routine monitoring of the serum level. The present study was designed to analyze the cardio-toxic side effect of Li and the ability of grape seed and skin extract (GSSE) to protect the heart against such toxicity. After 30days of exposure to Li (0, 2, 5 and 100mg/kg bw) and prevention with GSSE (4000mg/kg bw), rats were killed by decapitation and their heart processed for Li-induced oxidative stress...
September 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28921462/bifidobacterium-pseudocatenulatum-cect-7765-ameliorates-neuroendocrine-alterations-associated-with-an-exaggerated-stress-response-and-anhedonia-in-obese-mice
#7
Ana Agusti, A Moya-Pérez, I Campillo, S Montserrat-de la Paz, V Cerrudo, A Perez-Villalba, Yolanda Sanz
Obesity, besides being a problem of metabolic dysfunction, constitutes a risk factor for psychological disorders. Experimental models of diet-induced obesity have revealed that obese animals are prone to anxious and depressive-like behaviors. The present study aimed to evaluate whether Bifidobacterium pseudocatenulatum CECT 7765 could reverse the neurobehavioral consequences of obesity in a high-fat diet (HFD) fed mouse model via regulation of the gut-brain axis. Adult male wild-type C57BL-6 mice were fed a standard diet or HFD, supplemented with either placebo or the bifidobacterial strain for 13 weeks...
September 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28917487/glutamate-attenuates-lipopolysaccharide-induced-oxidative-damage-and-mrna-expression-changes-of-tight-junction-and-defensin-proteins-inflammatory-and-apoptosis-response-signaling-molecules-in-the-intestine-of-fish
#8
Jun Jiang, Long Yin, Jin-Yang Li, Qian Li, Dan Shi, Lin Feng, Yang Liu, Wei-Dan Jiang, Pei Wu, Ye Zhao, Xiao-Qiu Zhou
The present study explored the possible preventive effects of dietary glutamate (Glu) on LPS-induced oxidative damage, mRNA expression changes of tight junction (TJ) proteins and defensins, inflammatory and apoptosis response signaling molecules in fish intestine. Young Jian carp were fed five diets supplemental graded levels of Glu (0, 4, 8, 16 and 32 g kg(-1) diet) for 63 days. The results indicated that Glu supplementation depressed LPS induced the production of reactive oxygen species (ROS) and severe oxidative damage (lipid peroxidation and protein oxidation) in fish intestine, which was partially due to the increased glutathione (GSH) content and antioxidant enzyme activities including superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione-S-transferase (GST), and glutathione reductase (GR) (P < 0...
September 13, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28916954/discrimination-and-mental-health-in-a-representative-sample-of-african-american-and-afro-caribbean-youth
#9
Lee M Pachter, Cleopatra H Caldwell, James S Jackson, Bruce A Bernstein
BACKGROUND: Racism and discrimination are psychosocial stressors that affect the health of minority populations. While discrimination has been associated with poor mental health, little is known about the relationship between discrimination and mental health outcomes in youth nationally. Furthermore, mental and behavioral health consequences of discrimination may differ in different minority groups. OBJECTIVE: The goal of this study is to determine (1) how common perceptions of discrimination are in a nationally representative sample of African-American (AA) and Afro-Caribbean (AC) teens, (2) the relationship between discrimination and mental health conditions, and (3) whether discrimination has different associations with mental health in AA and AC youth...
September 15, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28914205/vitamin-d-and-depression-the-evidence-from-an-indirect-clue-to-treatment-strategy
#10
Sok Kuan Wong, Kok Yong Chin, Soelaiman Ima-Nirwana
Depression is a common psychiatric disorder that decreases the quality of life and increases the mortality of patients. It incurs significant healthcare costs if left untreated. Even though intervention with antidepressants can reduce depressive symptoms, side effects are often an issue and relapse is very common. Vitamin D, commonly known as the sunshine vitamin, is an essential fat-soluble vitamin for the absorption of calcium to prevent rickets (children) and osteomalacia (adults). Evidence on a possible relationship between vitamin D deficiency and depression is growing...
September 13, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28913617/fingolimod-induces-neuronal-specific-gene-expression-with-potential-neuroprotective-outcomes-in-maturing-neuronal-progenitor-cells-exposed-to-hiv
#11
Rebeca Geffin, Ricardo Martinez, Alicia de Las Pozas, Biju Issac, Micheline McCarthy
Fingolimod (FTY720), a structural analogue of sphingosine, targets sphingosine-1-phosphate receptor signaling and is currently an immunomodulatory therapy for multiple sclerosis. Fingolimod accesses the central nervous system (CNS) where its active metabolite, fingolimod phosphate (FTY720-P), has pleotropic neuroprotective effects in an inflammatory microenvironment. To investigate potential neuronal-specific mechanisms of fingolimod neuroprotection, we cultured the human neuronal progenitor cell line, hNP1, in differentiation medium supplemented with HIV- or Mock-infected supernatants, with or without FTY720-P...
September 14, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28905625/oral-ingestion-and-intraventricular-injection-of-curcumin-attenuates-the-effort-related-effects-of-the-vmat-2-inhibitor-tetrabenazine-implications-for-motivational-symptoms-of-depression
#12
Samantha E Yohn, Dea Gorka, Anisha Mistry, Samantha Collins, Emily Qian, Merce Correa, Arushi Manchanda, Robin H Bogner, John D Salamone
Effort-related choice tasks are used for studying depressive motivational symptoms such as anergia/fatigue. These studies investigated the ability of the dietary supplement curcumin to reverse the low-effort bias induced by the monoamine storage blocker tetrabenazine. Tetrabenazine shifted effort-related choice in rats, decreasing high-effort lever pressing but increasing chow intake. The effects of tetrabenazine were reversed by oral ingestion of curcumin (80.0-160.0 mg/kg) and infusions of curcumin into the cerebral ventricles (2...
September 14, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28900452/postpartum-home-care-and-its-effects-on-mothers-health-a-clinical-trial
#13
Hourieh Shamshiri Milani, Parastoo Amiri, Maryam Mohseny, Alireza Abadi, Seyyed Mohammadreza Vaziri, Marjan Vejdani
BACKGROUND: Postpartum home care plays an important role in prevention of postpartum complications. Regular visits of mothers during this period are imperative. This study aimed to provide postpartum home care for mothers to assess its effects on mothers' health in Iran. MATERIALS AND METHODS: This study was carried out in two phases. First, a comprehensive postpartum home care program was compiled by performing a comparative study, using the available guidelines in this regard in different countries and based on the opinions of the experts...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28899509/a-standardized-humulus-lupulus-l-ethanol-extract-partially-prevents-ovariectomy-induced-bone-loss-in-the-rat-without-induction-of-adverse-effects-in-the-uterus
#14
Annekathrin M Keiler, Janina Helle, Manuela I Bader, Tino Ehrhardt, Kristin Nestler, Georg Kretzschmar, Ricardo Bernhardt, Günter Vollmer, Dejan Nikolić, Judy L Bolton, Guido F Pauli, Shao-Nong Chen, Birgit M Dietz, Richard B van Breemen, Oliver Zierau
BACKGROUND: Hops (Humulus lupulus (L.)) dietary supplements are of interest as herbal remedies to alleviate menopausal symptoms, such as hot flushes, depression and anxiety. So far, the evidence regarding estrogenic and related properties of hops preparations has been considered insufficient for a market authorization for menopausal indications. PURPOSE: The study aims to investigate a chemically standardized hops extract regarding its safety in the uterus, as wells as its efficacy to prevent bone loss in the ovariectomized rat model...
October 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28892554/complementary-and-integrative-health-practices-for-depression
#15
Judy Haefner
The current article reviews selected complementary health approaches for the treatment of depressive symptoms. Complementary and integrative health (CIH) focuses on the whole person with the goal of optimal health-body, mind, and spirit. Patient use of integrative health practices and products is increasing; therefore, providers must understand these practices and products and be able to recommend or advise for or against their use based on research and guidelines. Difficulty with the current limitations of research on CIH practices is discussed, as these studies often may not have the same rigor or scientific weight as conventional treatment research...
September 11, 2017: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/28888611/comparison-of-mammary-lipid-metabolism-in-dairy-cows-and-goats-fed-diets-supplemented-with-starch-plant-oil-or-fish-oil
#16
L Bernard, P G Toral, Y Chilliard
A direct comparison of cow and goat performance and milk fatty acid (FA) responses to diets known to induce milk fat depression in the bovine has suggested interspecies differences in rumen and mammary lipid metabolism. Thus, this study was conducted to infer some potential mechanisms responsible for the differences in mammary lipogenesis due to diet and ruminant species. To meet this objective, 12 cows and 15 goats were fed a basal diet (control), a similar diet supplemented with 2.2% fish oil (FO), or a diet containing 5...
September 6, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28887315/inorganic-nitrate-in-angina-study-a-randomized-double-blind-placebo-controlled-trial
#17
Konstantin Schwarz, Satnam Singh, Satish K Parasuraman, Amelia Rudd, Lee Shepstone, Martin Feelisch, Magdalena Minnion, Shakil Ahmad, Melanie Madhani, John Horowitz, Dana K Dawson, Michael P Frenneaux
BACKGROUND: In this double-blind randomized placebo-controlled crossover trial, we investigated whether oral sodium nitrate, when added to existing background medication, reduces exertional ischemia in patients with angina. METHODS AND RESULTS: Seventy patients with stable angina, positive electrocardiogram treadmill test, and either angiographic or functional test evidence of significant ischemic heart disease were randomized to receive oral treatment with either placebo or sodium nitrate (600 mg; 7 mmol) for 7 to 10 days, followed by a 2-week washout period before crossing over to the other treatment (n=34 placebo-nitrate, n=36 nitrate-placebo)...
September 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28885270/association-between-internalized-hiv-related-stigma-and-hiv-care-visit-adherence
#18
Whitney S Rice, Kaylee Burnham, Michael J Mugavero, James L Raper, Ghislaine C Atkins, Bulent Turan
BACKGROUND: Internalized HIV-related stigma acts as a barrier to antiretroviral therapy (ART) adherence, but its effects on other HIV care continuum outcomes is unclear. METHODS: Among 196 HIV clinic patients in Birmingham, Alabama, we assessed internalized HIV-related stigma and depressive symptom severity using validated multi-item scales, and assessed ART adherence using a validated single-item measure. HIV visit adherence (attended out of total scheduled visits) was calculated using data from clinic records...
September 6, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28883733/fan-the-flame-trazodone-induced-mania-in-a-unipolar-depressed-patient-with-stable-sertraline-treatment
#19
Jianbo Hu, Jianbo Lai, Hanzhi Zheng, Shaohua Hu, Yi Xu
Depressed patients often complain of sleep disturbance. Routine antidepressive strategies sometimes fail to deal with this intractable issue. Indeed, the supplementation of sleep promoting antidepressants (eg, trazodone, mirtazapine, and agomelatine) is prevalent in clinical practice. However, the combination of different antidepressants may increase the affective lability. Herein, we document a patient with unipolar depression who was compliant with sertraline treatment and who dramatically switched to mania after adding trazodone as a sleeping aid...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28874913/brief-internet-based-cognitive-behavior-therapy-program-with-a-supplement-drink-improved-anxiety-and-somatic-symptoms-in-japanese-workers
#20
Kentaro Shirotsuki, Yuji Nonaka, Jiro Takano, Keiichi Abe, So-Ichiro Adachi, Shohei Adachi, Mutsuhiro Nakao
BACKGROUND: Self-help cognitive behavior therapy (CBT) is a useful approach for the treatment of psychological problems. Recent research on the effectiveness of self-help internet-based CBT (ICBT) indicates that the paradigm moderately improves psychological problems. Furthermore, previous studies have shown that food and drinks containing supplements improve various health conditions. We investigated the effect of a brief self-help ICBT administered with a supplement drink on psychological well-being and somatic symptoms...
2017: BioPsychoSocial Medicine
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