keyword
MENU ▼
Read by QxMD icon Read
search

Caramella

keyword
https://www.readbyqxmd.com/read/28522411/halloysite-and-chitosan-oligosaccharide-nanocomposite-for-wound-healing
#1
Giuseppina Sandri, Carola Aguzzi, Silvia Rossi, Maria Cristina Bonferoni, Giovanna Bruni, Cinzia Boselli, Antonia Icaro Cornaglia, Federica Riva, Cesar Viseras, Carla Caramella, Franca Ferrari
Halloysite is a natural nanotubular clay mineral (HNTs, Halloysite Nano Tubes) chemically identical to kaolinite and, due to its good biocompatibility, is an attractive nanomaterial for a vast range of biological applications. Chitosan oligosaccharides are homo- or heterooligomers of N-acetylglucosamine and D-glucosamine, that accelerate wound healing by enhancing the functions of inflammatory and repairing cells. The aim of the work was the development of a nanocomposite based on HNTs and chitosan oligosaccharides, to be used as pour powder to enhance healing in the treatment of chronic wounds...
May 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28522002/freeze-dried-cylinders-carrying-chitosan-nanoparticles-for-vaginal-peptide-delivery
#2
Marzia Marciello, Silvia Rossi, Carla Caramella, Carmen Remuñán-López
Recently nanoparticle-based vaginal drug delivery formulations have been acquiring great attention for the administration of peptide based-vaccines or microbicides to prevent or treat sexually transmitted diseases. In this work, a straightforward and efficient strategy for the vaginal application and release of peptide-loaded mucoadhesive nanoparticles was developed. This essentially consists of chitosan nanoparticles encapsulated in suitable hydrophilic freeze-dried cylinders. Chitosan nanoparticles are responsible for carrying the peptide drug and allowing adhesion to the vaginal mucosal epithelium...
August 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28479520/trepanation-to-treat-a-head-wound-a-case-of-neurosurgery-from-13-th-century-tuscany
#3
REVIEW
Giulia Riccomi, Gino Fornaciari, Angelica Vitiello, Anna Bini, Davide Caramella, Valentina Giuffra
During the archaeological excavations conducted in the 13(th) century cemetery of the Church of S. Agostino in Poggibonsi, Tuscany (Italy), a skull with evidences of neurosurgical intervention was brought to light. The skull, belonging to an adult male, shows two traumatic lesions produced by bladed instruments. The first lesion, located on the anterior part of the parietal bones, involved only the outer cranial table; bone remodeling indicates that the individual survived the injury for a long time. The second lesion, located on the frontal bone, involved all the thickness of the bone; the absence of reparative processes allows a diagnosis of peri mortem lesion...
May 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28445990/prognostic-value-of-tumor-mutations-in-radically-treated-locally-advanced-non-small-cell-lung-cancer-patients
#4
Angela Boros, Ludovic Lacroix, Benjamin Lacas, Julien Adam, Jean-Pierre Pignon, Caroline Caramella, David Planchard, Vincent de Montpreville, Eric Deutsch, Antonin Levy, Benjamin Besse, Cécile Le Pechoux
INTRODUCTION: Chemo-radiation is standard treatment in locally advanced non-small cell lung cancers (NSCLC). The prognostic value of mutations has been poorly explored in this population. RESULTS: Clinical data were collected from 190 patients and mutational profiles were obtained in 78 of them; 58 (74%) were males, 31 (40%) current smokers, 47/31 stage IIIA/IIIB and 40 (51%) adenocarcinoma. The following mutations were identified: EGFR 12% (9/78), KRAS 15% (12/78), BRAF 5% (3/65), PI3KCA 2% (1/57), NRAS 3% (1/32), and ALK+ (FISH) 4% (2/51)...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28378910/innovative-methods-and-applications-in-mucoadhesion-research
#5
REVIEW
Alan R Mackie, Francisco M Goycoolea, Bianca Menchicchi, Carla Marcella Caramella, Francesca Saporito, Seunghwan Lee, Karen Stephansen, Ioannis S Chronakis, Marianne Hiorth, Malgorzata Adamczak, Max Waldner, Hanne Mørck Nielsen, Luciano Marcelloni
The present review is aimed at elucidating relatively new aspects of mucoadhesion/mucus interaction and related phenomena that emerged from a Mucoadhesion workshop held in Munster on 2-3 September 2015 as a satellite event of the ICCC 13th-EUCHIS 12th. After a brief outline of the new issues, the focus is on mucus description, purification, and mucus/mucin characterization, all steps that are pivotal to the understanding of mucus related phenomena and the choice of the correct mucosal model for in vitro and ex vivo experiments, alternative bio/mucomimetic materials are also presented...
April 5, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28284321/matrix-metalloproteinases-and-airway-remodeling-and-function-in-primary-ciliary-dyskinesia
#6
Massimo Pifferi, Andrew Bush, Davide Caramella, Maria Rita Metelli, Maria Di Cicco, Martina Piras, Giulia Gherarducci, Carlo Capristo, Fabrizio Maggi, Diego Peroni, Attilio L Boner
BACKGROUND: The balance between matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) is important in the regulation of airway damage. OBJECTIVE: To evaluate whether they are important in the pathophysiology of primary and secondary ciliary dyskinesia (PCD, SCD). METHODS: We measured sputum bacteriology, lung CT changes, MMPs, TIMPs and lung function in 86 patients (51 PCD, 35 SCD) in a cross-sectional study; the 10 controls studied did not have HRCT or sputum cultures...
March 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28271869/irecist-guidelines-for-response-criteria-for-use-in-trials-testing-immunotherapeutics
#7
REVIEW
Lesley Seymour, Jan Bogaerts, Andrea Perrone, Robert Ford, Lawrence H Schwartz, Sumithra Mandrekar, Nancy U Lin, Saskia Litière, Janet Dancey, Alice Chen, F Stephen Hodi, Patrick Therasse, Otto S Hoekstra, Lalitha K Shankar, Jedd D Wolchok, Marcus Ballinger, Caroline Caramella, Elisabeth G E de Vries
Tumours respond differently to immunotherapies compared with chemotherapeutic drugs, raising questions about the assessment of changes in tumour burden-a mainstay of evaluation of cancer therapeutics that provides key information about objective response and disease progression. A consensus guideline-iRECIST-was developed by the RECIST working group for the use of modified Response Evaluation Criteria in Solid Tumours (RECIST version 1.1) in cancer immunotherapy trials, to ensure consistent design and data collection, facilitate the ongoing collection of trial data, and ultimate validation of the guideline...
March 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28242503/antitumour-activity-of-somatostatin-analogues-in-sporadic-progressive-metastatic-pulmonary-carcinoids
#8
Ivana Sullivan, Gwénaël Le Teuff, Joël Guigay, Caroline Caramella, Amandine Berdelou, Sophie Leboulleux, Désirée Déandréis, Julien Hadoux, Michel Ducreux, Pierre Duvillard, Julien Adam, Jean-Yves Scoazec, Eric Baudin, David Planchard
PURPOSE: Antiproliferative activity of somatostatin analogues (SSAs) has been demonstrated in digestive neuroendocrine tumours but few data have been published on pulmonary carcinoids (PC). The aim of this retrospective study was to report the antitumour activity of SSAs in patients with progressive, metastatic PC. METHODS: Patients with PC and treated with SSA monotherapy were reviewed. Disease was classified according to the tumour slope prior to SSA initiation as rapidly progressive (at least 20% increase in the sum of the longest diameter of target lesions or the appearance of one or more new lesions within 6 months) or slowly progressive (if progression occurred over 6 months)...
February 24, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28177097/-spontaneous-rupture-of-a-simple-renal-cyst-clinical-management
#9
Luca Estienne, Maria Valentina Domenech, Elena Caramella, Marta Calatroni, Alessandro Avella, Ilaria Massa, Stefania Bianzina, Nicoletta Serpieri, Pasquale Esposito
Spontaneous renal bleeding mainly occurs in patients with polycystic kidney diseases or cancer. Indeed, despite the high prevalence of simple cysts, their spontaneous atraumatic rupture is a rare event. Underlying mechanisms may involve the increase of intracystic pressure and/or the development of a haemorrhage into the cyst. Management of this condition includes surgery, interventional radiology or conservative strategies. Here, we report a case of spontaneous rupture of a simple renal cyst, successfully managed with conservative treatment...
January 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/28152462/a-novel-ionic-amphiphilic-chitosan-derivative-as-a-stabilizer-of-nanoemulsions-improvement-of-antimicrobial-activity-of-cymbopogon-citratus-essential-oil
#10
Maria Cristina Bonferoni, Giuseppina Sandri, Silvia Rossi, Donatella Usai, Ioannis Liakos, Alice Garzoni, Maura Fiamma, Stefania Zanetti, Athanassia Athanassiou, Carla Caramella, Franca Ferrari
Amphiphilic chitosans have been recently proposed to improve delivery of poorly soluble drugs. In the present paper a derivative obtained by ionic interaction between chitosan and oleic acid was for the first time studied to physically stabilize o/w nanoemulsions of an antimicrobial essential oil, Cymbopogon citratus (Lemongrass), in a low energy and mild conditions emulsification process. The novel combination of spontaneous emulsification process with chitosan oleate amphiphilic properties resulted in a stable dispersion of a few hundred nanometer droplets...
April 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28104619/osimertinib-benefit-in-egfr-mutant-nsclc-patients-with-t790m-mutation-detected-by-circulating-tumour-dna
#11
J Remon, C Caramella, C Jovelet, L Lacroix, A Lawson, S Smalley, K Howarth, D Gale, E Green, V Plagnol, N Rosenfeld, D Planchard, M V Bluthgen, A Gazzah, C Pannet, C Nicotra, E Auclin, J C Soria, B Besse
Background: Approximately 50% of epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC) patients treated with EGFR tyrosine kinase inhibitors (TKIs) will acquire resistance by the T790M mutation. Osimertinib is the standard of care in this situation. The present study assesses the efficacy of osimertinib when T790M status is determined in circulating cell-free tumour DNA (ctDNA) from blood samples in progressing advanced EGFR-mutant NSCLC patients. Material and methods: ctDNA T790M mutational status was assessed by Inivata InVision™ (eTAm-Seq™) assay in 48 EGFR-mutant advanced NSCLC patients with acquired resistance to EGFR TKIs without a tissue biopsy between April 2015 and April 2016...
April 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28088003/the-effect-of-the-antioxidant-on-the-properties-of-thiolated-poly-aspartic-acid-polymers-in-aqueous-ocular-formulations
#12
Mária Budai-Szűcs, Gabriella Horvát, Benjámin Gyarmati, Barnabás Áron Szilágyi, András Szilágyi, Szilvia Berkó, Rita Ambrus, Piroska Szabó-Révész, Giuseppina Sandri, Maria Cristina Bonferoni, Carla Caramella, Erzsébet Csányi
Thiolated polymers are a promising new group of excipients, but their stability against atmospheric oxidation has not been investigated in detail, and only a few efforts have been made to improve their stability. The oxidation of the thiol groups in solutions of thiolated polymers may result in a decrease of mucoadhesion and unpredictable in situ gelation. The aims of our work were to study the stability of aqueous solutions of thiolated polymers and the effects of stabilizing agents. We investigated thiolated poly(aspartic acid) polymers stabilized with dithiothreitol, glutathione or acetylcysteine...
April 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28027740/awareness-of-radiation-protection-and-dose-levels-of-imaging-procedures-among-medical-students-radiography-students-and-radiology-residents-at-an-academic-hospital-results-of-a-comprehensive-survey
#13
Lorenzo Faggioni, Fabio Paolicchi, Luca Bastiani, Davide Guido, Davide Caramella
PURPOSE: To evaluate the awareness of radiation protection issues and the knowledge of dose levels of imaging procedures among medical students, radiology residents, and radiography students at an academic hospital. MATERIAL AND METHODS: A total of 159 young doctors and students (including 60 radiology residents, 56 medical students, and 43 radiography students) were issued a questionnaire consisting of 16 multiple choice questions divided into three separated sections (i...
January 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/27989765/chitosan-coupled-solid-lipid-nanoparticles-tuning-nanostructure-and-mucoadhesion
#14
Giuseppina Sandri, Simona Motta, Maria Cristina Bonferoni, Paola Brocca, Silvia Rossi, Franca Ferrari, Valeria Rondelli, Laura Cantù, Carla Caramella, Elena Del Favero
Solid Lipid Nanoparticles (SLNs) composed of biodegradable physiological lipids have been widely proposed as efficient drug delivery systems, also for ophthalmic administration. Recently, chitosan-associated-SLNs have been developed to further improve the residence time of these colloidal systems in the precorneal area by means of mucoadhesive interaction. In the present study, a one-step preparation protocol was used aiming both at scale-up ease and at stronger coupling between chitosan and SLNs. The resulting particles were chitosan associated-SLNs (CS-SLNs)...
January 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27885272/driver-mutations-effect-in-secondary-myelofibrosis-an-international-multicenter-study-based-on-781-patients
#15
F Passamonti, B Mora, T Giorgino, P Guglielmelli, M Cazzola, M Maffioli, A Rambaldi, M Caramella, R Komrokji, J Gotlib, J J Kiladjian, F Cervantes, T Devos, F Palandri, V De Stefano, M Ruggeri, R Silver, G Benevolo, F Albano, D Caramazza, E Rumi, M Merli, D Pietra, R Casalone, T Barbui, L Pieri, A M Vannucchi
No abstract text is available yet for this article.
April 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27830869/atlas-occipitalization-associated-with-other-anomalies-in-a-16th-century-skeleton-from-sardinia-italy
#16
Valentina Giuffra, Andrea Montella, Marco Milanese, Eugenia Tognotti, Davide Caramella, Pasquale Bandiera
Archaeological excavations carried out in the plague cemetery of 16th century Alghero (Sardinia) brought to light the skeleton of a male aged 35-45 years, showing anomalies of the atlas. A macroscopic and radiological study has been carried out. The first cervical vertebra is fused with the skull base, resulting in an occipitalization of the atlas. Absence of the costal element of the left foramen trasversarium, resulting in an open anterior foramen trasversarium, and posterior arch defect are also observed...
November 10, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27789370/application-of-doe-approach-in-the-development-of-mini-capsules-based-on-biopolymers-and-manuka-honey-polar-fraction-as-powder-formulation-for-the-treatment-of-skin-ulcers
#17
Marika Tenci, Silvia Rossi, Maria Cristina Bonferoni, Giuseppina Sandri, Irene Mentori, Cinzia Boselli, Antonia Icaro Cornaglia, Maria Daglia, Anna Marchese, Carla Caramella, Franca Ferrari
The aim of the present work was the development of a powder formulation for the delivery of manuka honey (MH) bioactive components in the treatment of chronic skin ulcers. In particular pectin (PEC)/chitosan glutamate (CS)/hyaluronic acid (HA) mini-capsules were obtained by inverse ionotropic gelation in presence of calcium chloride and subsequently freeze-dried. Optimization of unloaded (blank) formulation was performed using DoE approach. In a screening phase, the following three factors were investigated at two levels: CS (0...
January 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27626634/from-cortical-and-subcortical-grey-matter-abnormalities-to-neurobehavioral-phenotype-of-angelman-syndrome-a-voxel-based-morphometry-study
#18
Gayane Aghakhanyan, Paolo Bonanni, Giovanna Randazzo, Sara Nappi, Federica Tessarotto, Lara De Martin, Francesca Frijia, Daniele De Marchi, Francesco De Masi, Beate Kuppers, Francesco Lombardo, Davide Caramella, Domenico Montanaro
Angelman syndrome (AS) is a rare neurogenetic disorder due to loss of expression of maternal ubiquitin-protein ligase E3A (UBE3A) gene. It is characterized by severe developmental delay, speech impairment, movement or balance disorder and typical behavioral uniqueness. Affected individuals show normal magnetic resonance imaging (MRI) findings, although mild dysmyelination may be observed. In this study, we adopted a quantitative MRI analysis with voxel-based morphometry (FSL-VBM) method to investigate disease-related changes in the cortical/subcortical grey matter (GM) structures...
2016: PloS One
https://www.readbyqxmd.com/read/27553112/robotic-pancreatoduodenectomy-with-vascular-resection
#19
REVIEW
Emanuele F Kauffmann, Niccolò Napoli, Francesca Menonna, Fabio Vistoli, Gabriella Amorese, Daniela Campani, Luca Emanuele Pollina, Niccola Funel, Carla Cappelli, Davide Caramella, Ugo Boggi
PURPOSE: This study aims to define the current status of robotic pancreatoduodenectomy (RPD) with resection and reconstruction of the superior mesenteric/portal vein (RPD-SMV/PV). METHODS: Our experience on RPD, including RPD-SMV/PV, is presented along with a description of the surgical technique and a systematic review of the literature on RPD-SMV/PV. RESULTS: We have performed 116 RPD and 14 RPD-SMV/PV. Seven additional cases of RPD-SMV/PV were identified in the literature...
December 2016: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/27544055/brain-radionecrosis-treated-with-bevacizumab-in-a-patient-with-resected-squamous-cell-carcinoma-of%C3%A2-the-lung
#20
Jordi Remon, Cécile Le Péchoux, Caroline Caramella, Frederic Dhermain, Guillame Louvel, Jean-Charles Soria, Benjamin Besse
No abstract text is available yet for this article.
January 2017: Journal of Thoracic Oncology
keyword
keyword
90787
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"