keyword
MENU ▼
Read by QxMD icon Read
search

Caramella

keyword
https://www.readbyqxmd.com/read/29166754/advances-in-oncological-treatment-limitations-of-recist-1-1-criteria
#1
Serena Grimaldi, Marie Terroir, Caroline Caramella
INTRODUCTION: RECIST 1.1 criteria are the standard for the response assessment of most solid tumors on computed tomography (CT). Nevertheless, the emergence of new classes of treatment in the lasts decades has brought new challenges in the response evaluation. EVIDENCE ACQUISITION: A PubMed online database literature search was performed in order to identify papers in English with full text available published up to September 2017. EVIDENCE SYNTHESIS: Some oncologic treatments, such as anti-angiogenic agents, immunotherapy and local treatments, have proven to be effective despite atypical patterns of responses...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29164573/role-of-perfusion-ct-in-the-evaluation-of-metastatic-nodal-tumor-response-after-radiochemotherapy-in-head-and-neck-cancer-preliminary-findings
#2
S Ursino, L Faggioni, F Fiorica, D Delishaj, V Seccia, F Pasqualetti, I Desideri, C Colosimo, R Morganti, F Paiar, D Caramella
OBJECTIVE: To assess changes of CT perfusion parameters (ΔPCTp) of cervical lymph node metastases from head and neck cancer (HNC) before and after radiochemotherapy (RT-CT) and their association with nodal tumor persistence. PATIENTS AND METHODS: Eligibility criteria included HNC (Stage III-IV) candidates for RT-CT. Patients underwent perfusion CT (PCT) at baseline 3 weeks and 3 months after RT-CT. Blood volume (BV), blood flow (BF), mean transit time (MTT) and permeability surface (PS) were calculated...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29155053/alpha-tocopherol-loaded-chitosan-oleate-nanoemulsions-for-wound-healing-evaluation-on-cell-lines-and-ex-vivo-human-biopsies-and-stabilization-in-spray-dried-trojan-microparticles
#3
M C Bonferoni, F Riva, A Invernizzi, E Dellera, G Sandri, S Rossi, G Marrubini, G Bruni, B Vigani, C Caramella, F Ferrari
An amphiphilic chitosan salt, chitosan oleate (CS-OA), was previously proposed for the physical stabilization of lemongrass antimicrobial nanoemulsions (NE) through a mild spontaneous emulsification process. As both chitosan and oleic acid are described in the literature for their positive effects in wound healing, in the present study CS-OA has been proposed to encapsulate alpha tocopherol (αTph) in NEs aimed to skin wounds. A NE formulation was developed showing about 220 nm dimensions, 36% drug loading, and αTph concentration up to 1 mg/ml...
November 15, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29119524/radiation-dose-exposure-in-patients-affected-by-lymphoma-undergoing-repeat-ct-examinations-how-to-manage-the-radiation-dose-variability
#4
Fabio Paolicchi, Luca Bastiani, Davide Guido, Antonio Dore, Giacomo Aringhieri, Davide Caramella
PURPOSE: To assess the variability of radiation dose exposure in patients affected by lymphoma undergoing repeat CT (computed tomography) examinations and to evaluate the influence of different scan parameters on the overall radiation dose. MATERIALS AND METHODS: A series of 34 patients (12 men and 22 women with a median age of 34.4 years) with lymphoma, after the initial staging CT underwent repeat follow-up CT examinations. For each patient and each repeat examination, age, sex, use of AEC system (Automated Exposure Control, i...
November 8, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28948476/feasibility-of-intraoral-ultrasonography-in-the-diagnosis-of-oral-soft-tissue-lesions-a-preclinical-assessment-on-an-ex-vivo-specimen
#5
Rossana Izzetti, Gualtiero Fantoni, Francesca Gelli, Lorenzo Faggioni, Saverio Vitali, Mario Gabriele, Davide Caramella
OBJECTIVES: The early detection of oral soft tissue lesions is an important prognostic factor, and the possibility of using ultrasonography (US) as a diagnostic tool may improve the diagnosis and characterization of tissue alterations at an early stage. This study aims to evaluate the feasibility of intraoral US by performing a preclinical assessment of an ex vivo specimen in which focal lesions were simulated. MATERIALS AND METHODS: Fourteen lesions were simulated on a freshly extracted calf tongue, by introducing in the tongue different materials mimicking the appearance of various focal lesions...
September 25, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28852434/a-new-natural-antioxidant-mixture-protects-against-oxidative-and-dna-damage-in-endothelial-cell-exposed-to-low-dose-irradiation
#6
T Cervelli, D Panetta, T Navarra, S Gadhiri, P Salvadori, A Galli, D Caramella, G Basta, E Picano, S Del Turco
Exposure to ionizing radiation during diagnostic procedures increases systemic oxidative stress and predisposes to higher risk of cancer and cardiovascular disease development. Many studies indicated that antioxidants protect against radiation-induced damage and have high efficacy and lack of toxicity in preventing radiation exposure damages. The purpose of this study was to investigate the in vitro protective effect of a new antioxidant mixture, named RiduROS, on oxidative stress generation and DNA double-strand breaks (DSBs) induced by low doses of X-rays in endothelial cells...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28844832/radiofrequency-ablation-in-the-treatment-of-benign-thyroid-nodules-an-efficient-and-safe-alternative-to-surgery
#7
Rosa Cervelli, Salvatore Mazzeo, Luigi De Napoli, Antonio Boccuzzi, Benedetta Pontillo-Contillo, Gabriele Materazzi, Paolo Miccoli, Roberto Cioni, Davide Caramella
PURPOSE: To evaluate the efficacy and safety of radiofrequency (RF) ablation in the treatment of benign thyroid nodules (BTNs) by applying a modification of the moving-shot technique. MATERIALS AND METHODS: Fifty-one BTNs in 46 patients for whom surgery was contraindicated or who refused surgery were treated with RF ablation: 31 had lesion volumes < 20 cm(3) (group A) and 20 had volumes ≥ 20 cm(3) (group B). The solid component percentage of each lesion was assessed, and any present fluid component was aspirated...
October 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28844707/are-we-reproducible-in-measurement-of-net-liver-metastasis
#8
Salma Moalla, Julia Arfi Rouche, Stéphanie Foulon, Caroline Caramella, Nils Ternes, David Planchard, Diane Goere, Michel Ducreux, Jean Yves Scoazec, Frederic Deschamps, Clarisse Dromain, Eric Baudin
Accurate measurement of well-differentiated neuroendocrine tumours (NET) liver metastases is critical to determine tumour slope and to assess treatment efficacy. Our objectives were to determine which CT or MRI sequence is the most reproducible to measure NET liver metastases and to assess the percentage of variability of measurements. Intra and inter-observer variability were studied on triphasic abdominal CT or liver MRI in 22 and 32 NET patients respectively. Patients were treatment-naïve or under somatostatin analogues...
June 28, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28748315/interferon-alpha-treatment-for-disease-control-in-metastatic-pheochromocytoma-paraganglioma-patients
#9
Julien Hadoux, Marie Terroir, Sophie Leboulleux, Frederic Deschamps, Abir Al Ghuzlan, Ségolène Hescot, Lambros Tselikas, Isabelle Borget, Caroline Caramella, Desirée Déandréis, Diane Goere, Thierry De Baere, Martin Schlumberger, Eric Baudin
Interferon-alpha (IFN-alpha) is recommended in neuroendocrine tumors (NET). Malignant pheochromocytoma and paragangliomas (MPPGLs) constitute a rare subgroup of NET with few treatment options. IFN-alpha efficacy in patients with MPPGLs was evaluated in a single-center retrospective study. Progression-free survival (PFS) was the primary endpoint according to RECIST 1.1 and/or PERCIST 1.0, and response rate, safety, and symptomatic efficacy were secondary endpoints. Fourteen patients received peginterferon alfa-2a (90 to 180 μg/week) or interferon alfa-2b (1...
December 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/28735992/global-performance-status-score-a-new-tool-to-assess-physical-performance-in-kidney-transplant-patients
#10
P Esposito, F Furini, M Gregorini, E F Pattonieri, V Corradetti, E La Porta, E Caramella, M Calatroni, L Petrucci, C Klersy, T Rampino
BACKGROUND: Information on physical performance in renal transplantation is limited because of the shortage of specifically designed evaluation instruments. Therefore, we elaborated and validated the Global Performance Status (GloPerSta) score to provide a new and comprehensive tool, exploring the different components of physical performance in kidney transplant patients. METHODS: We elaborated the GloPerSta score on the basis of the data obtained from a cross-sectional study, in which we evaluated the physical performance of a cohort of kidney transplant patients...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28729970/severe-cyclophosphamide-related-hyponatremia-in-a-patient-with-acute-glomerulonephritis
#11
Pasquale Esposito, Maria Valentina Domenech, Nicoletta Serpieri, Marta Calatroni, Ilaria Massa, Alessandro Avella, Edoardo La Porta, Luca Estienne, Elena Caramella, Teresa Rampino
Cyclophosphamide is frequently used to treat cancer, autoimmune and renal diseases, such as rapidly progressive glomerulonephritis. Its side effects are well-known, including bone marrow depression, infections, alopecia, sterility, bladder malignancy and hemorrhagic cystitis. Moreover, in some cases cyclophosphamide use has been related to the onset of hyponatremia, by development of a syndrome of inappropriate antidiuresis. Indeed, severe hyponatremia has been previously reported in patients treated with high-dose or moderate-dose of intravenous cyclophosphamide, while only few cases have been reported in patients treated with low dose...
July 6, 2017: World Journal of Nephrology
https://www.readbyqxmd.com/read/28700184/-report-for-the-world-kidney-days-in-italy-2015-2016
#12
Pasquale Esposito, Yuri Battaglia, Elena Caramella, Domenico Russo, Alessandro Balducci
World Kidney Day (WKD) is a global campaign, promoted by International Federation of Kidney Foundations (IFKF) and International Society of Nephrology (ISN) aimed at raising awareness among people on importance of our kidneys. This campaign includes many events across the globe. The main purpose of WKD is to create and spread awareness about preventive behaviours and risk factors for renal diseases. In Italy WKD is organized by the Italian Kidney Foundation (FIR) in collaboration with Italian Society of Nephrology (SIN) and the Red Cross of Italy...
June 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/28700180/-superior-cava-vein-stenosis-in-a-hemodialysis-patient-with-long-term-central-venous-catheter-and-vascular-graft-a-case-report
#13
Carlo Jovane, Piera Farfaglia, Anna Maria Ierardi, Laura Rimoldi, Elisabetta Sogni, Carmela Figliola, Daniela Pogliani, Matteo Tozzi, Elena Caramella, Pasquale Esposito, Alessandro Castiglioni
Recently, the use of central venous catheters (CVC) as a vascular access in patients undergoing hemodialysis is significantly increased, mainly because of the aging of this population and the presence of several comorbidities. However, the implantation and the long stay of CVC are associated with many complications. Among them, central venous stenosis represents one of the most common problems that, if not properly diagnosed, could lead to vascular thrombosis and consequent vascular access malfunction. Here, we report a case of a 38-year-old patient, who underwent hemodialysis firstly by a CVC long-term into right jugular vein and then by a prosthetic fistula in the ipsilateral limb...
June 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/28678209/nanofiber-scaffolds-as-drug-delivery-systems-to-bridge-spinal-cord-injury
#14
REVIEW
Angela Faccendini, Barbara Vigani, Silvia Rossi, Giuseppina Sandri, Maria Cristina Bonferoni, Carla Marcella Caramella, Franca Ferrari
The complex pathophysiology of spinal cord injury (SCI) may explain the current lack of an effective therapeutic approach for the regeneration of damaged neuronal cells and the recovery of motor functions. A primary mechanical injury in the spinal cord triggers a cascade of secondary events, which are involved in SCI instauration and progression. The aim of the present review is to provide an overview of the therapeutic neuro-protective and neuro-regenerative approaches, which involve the use of nanofibers as local drug delivery systems...
July 5, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28645742/gastrointestinal-stromal-tumors-gist-presenting-in-the-liver-diagnostic-prognostic-and-therapeutic-issues
#15
Natacha Joyon, Jérôme Dumortier, Aude Aline-Fardin, Caroline Caramella, Pierre-Jean Valette, Jean-Yves Blay, Jean-Yves Scoazec, Peggy Dartigues
CONTEXT: Extra-gastrointestinal stromal tumors (E-GIST) presenting in the liver are exceedingly rare and raise difficult diagnostic and therapeutic challenges. METHODS: We report on two cases of liver E-GIST with different clinical presentations. We describe their clinical and imaging features, their histopathological and molecular characteristics, their treatment and their course. RESULTS: The first case was that of a 56-year-old male presenting with a 10-cm liver mass; the initial diagnosis, made in 1986 from a biopsy sample, was leiomyosarcoma; liver transplantation was performed in 1987; no extra-hepatic tumor was found; the course was uneventful until 1999, when tumor recurrence was diagnosed along the initial biopsy route; after reevaluation of available material, the definitive pathological diagnosis was GIST; imatinib treatment resulted in major response; the patient died of end-stage kidney disease 22 years after the initial diagnosis and 9 years after tumor recurrence...
June 20, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28633480/a-prospective-examination-of-circulating-tumor-cell-profiles-in-non-small-cell-lung-cancer-molecular-subgroups
#16
C R Lindsay, V Faugeroux, S Michiels, E Pailler, F Facchinetti, D Ou, M V Bluthgen, C Pannet, M Ngo-Camus, G Bescher, C Caramella, F Billiot, J Remon, D Planchard, J-C Soria, B Besse, F Farace
Background: We report the first study examining the clinical, numerical and biological properties of circulating tumor cells according to molecular subtypes of non-small-cell lung cancer. Patients and methods: 125 patients with treatment-naïve stage IIIb-IV NSCLC were prospectively recruited for CellSearch analysis. Anti-vimentin antibody was included for examination of CTCs to assess their mesenchymal character. Associations of total CTCs and vimentin-positive (vim +) CTCs with clinical characteristics, tumor genotype, and survival were assessed...
July 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28629572/3t-diffusion-weighted-mri-in-the-response-assessment-of-colorectal-liver-metastases-after-chemotherapy-correlation-between-adc-value-and-histological-tumour-regression-grading
#17
Francescamaria Donati, Piero Boraschi, Federica Pacciardi, Rosa Cervelli, Maura Castagna, Lucio Urbani, Fabio Falaschi, Davide Caramella
PURPOSE: The purpose of the study was to correlate the apparent diffusion coefficient (ADC) values of diffusion-weighted MR imaging (DW-MRI) by 3T device with the histological tumour regression grading (TRG) analysis of colorectal liver metastases after preoperative chemotherapy. MATERIALS AND METHODS: Our study included thirty-five patients with colorectal liver metastases who had undergone MRI by 3T device (GE DISCOVERY MR750; GE Healthcare) after preoperative chemotherapy...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28625652/symptomatic-leptomeningeal-metastasis-improvement-with-nivolumab-in-advanced-non-small-cell-lung-cancer-patient
#18
Maria Gion, Jordi Remon, Caroline Caramella, Jean-Charles Soria, Benjamin Besse
Leptomeningeal metastasis (LM) is reported in 3.8% of non-small-cell lung cancer (NSCLC) patients, more frequently in adenocarcinoma, and it correlates with poor prognosis. Data regarding the activity of immune checkpoint inhibitors in LM is lacking. We present a case report about the efficacy of nivolumab in a patient with advanced NSCLC and symptomatic LM.
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28619454/carvacrol-clay-hybrids-loaded-into-in-situ-gelling-films
#19
M Tenci, S Rossi, C Aguzzi, E Carazo, G Sandri, M C Bonferoni, P Grisoli, C Viseras, C M Caramella, F Ferrari
The aim of the present work was the development of polymer films loaded with a carvacrol (CVR)/clay hybrid (HYBD) for the delivery of CRV in infected skin ulcer treatment. Different clays were considered: montmorrilonite, halloysite and palygorskite (PHC). CRV incorporation in PHC reduced its volatility. HYBD showed 20% w/w CRV loading capacity and was able to preserve CRV antioxidant properties. HYBD was characterized by improved antimicrobial properties against S. aureus and E. coli and cytocompatibility towards human fibroblasts with respect to pure CRV...
June 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28561069/a-clinical-molecular-prognostic-model-to-predict-survival-in-patients-with-post-polycythemia-vera-and-post-essential-thrombocythemia-myelofibrosis
#20
F Passamonti, T Giorgino, B Mora, P Guglielmelli, E Rumi, M Maffioli, A Rambaldi, M Caramella, R Komrokji, J Gotlib, J J Kiladjian, F Cervantes, T Devos, F Palandri, V De Stefano, M Ruggeri, R T Silver, G Benevolo, F Albano, D Caramazza, M Merli, D Pietra, R Casalone, G Rotunno, T Barbui, M Cazzola, A M Vannucchi
Polycythemia vera (PV) and essential thrombocythemia (ET) are myeloproliferative neoplasms with variable risk of evolution into post-PV and post-ET myelofibrosis, from now on referred to as secondary myelofibrosis (SMF). No specific tools have been defined for risk stratification in SMF. To develop a prognostic model for predicting survival, we studied 685 JAK2, CALR, and MPL annotated patients with SMF. Median survival of the whole cohort was 9.3 years (95% CI: 8-not reached-NR-). Through penalized Cox regressions we identified negative predictors of survival and according to beta risk coefficients we assigned 2 points to hemoglobin level <11 g/dl, to circulating blasts ⩾3%, and to CALR-unmutated genotype, 1 point to platelet count <150 × 10(9)/l and to constitutional symptoms, and 0...
May 31, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
keyword
keyword
90787
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"