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https://www.readbyqxmd.com/read/28104619/osimertinib-benefit-in-egfr-mutant-nsclc-patients-with-t790m-mutation-detected-by-circulating-tumour-dna
#1
J Remon, C Caramella, C Jovelet, L Lacroix, A Lawson, S Smalley, K Howarth, D Gale, E Green, V Plagnol, N Rosenfeld, D Planchard, M V Bluthgen, A Gazzah, C Pannet, C Nicotra, E Auclin, J C Soria, B Besse
BACKGROUND: Approximately 50% of Epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC) patients treated with EGFR tyrosine kinase inhibitors (TKIs) will acquire resistance by the T790M mutation. Osimertinib is the standard of care in this situation. The present study assesses the efficacy of osimertinib when T790M status is determined in circulating cell-free tumour DNA (ctDNA) from blood samples in progressing advanced EGFR-mutant NSCLC patients. MATERIAL AND METHODS: ctDNA T790M mutational status was assessed by Inivata InVision(TM) (eTAm-Seq(TM)) assay in 48 EGFR-mutant advanced NSCLC patients with acquired resistance to EGFR TKIs without a tissue biopsy between April 2015 and April 2016...
January 18, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28088003/the-effect-of-the-antioxidant-on-the-properties-of-thiolated-poly-aspartic-acid-polymers-in-aqueous-ocular-formulations
#2
Mária Budai-Szűcs, Gabriella Horvát, Benjámin Gyarmati, Barnabás Áron Szilágyi, András Szilágyi, Szilvia Berkó, Rita Ambrus, Piroska Szabó-Révész, Giuseppina Sandri, Maria Cristina Bonferoni, Carla Caramella, Erzsébet Csányi
Thiolated polymers are a promising new group of excipients, but their stability against atmospheric oxidation has not been investigated in detail, and only a few efforts have been made to improve their stability. The oxidation of the thiol groups in solutions of thiolated polymers may result in a decrease of mucoadhesion and unpredictable in situ gelation. The aims of our work were to study the stability of aqueous solutions of thiolated polymers and the effects of stabilizing agents. We investigated thiolated poly(aspartic acid) polymers stabilized with dithiothreitol, glutathione or acetylcysteine...
January 11, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28027740/awareness-of-radiation-protection-and-dose-levels-of-imaging-procedures-among-medical-students-radiography-students-and-radiology-residents-at-an-academic-hospital-results-of-a-comprehensive-survey
#3
Lorenzo Faggioni, Fabio Paolicchi, Luca Bastiani, Davide Guido, Davide Caramella
PURPOSE: To evaluate the awareness of radiation protection issues and the knowledge of dose levels of imaging procedures among medical students, radiology residents, and radiography students at an academic hospital. MATERIAL AND METHODS: A total of 159 young doctors and students (including 60 radiology residents, 56 medical students, and 43 radiography students) were issued a questionnaire consisting of 16 multiple choice questions divided into three separated sections (i...
January 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/27989765/chitosan-coupled-solid-lipid-nanoparticles-tuning-nanostructure-and-mucoadhesion
#4
Giuseppina Sandri, Simona Motta, Maria Cristina Bonferoni, Paola Brocca, Silvia Rossi, Franca Ferrari, Valeria Rondelli, Laura Cantù, Carla Caramella, Elena Del Favero
Solid Lipid Nanoparticles (SLNs) composed of biodegradable physiological lipids have been widely proposed as efficient drug delivery systems, also for ophthalmic administration. Recently, chitosan-associated-SLNs have been developed to further improve the residence time of these colloidal systems in the precorneal area by means of mucoadhesive interaction. In the present study, a one-step preparation protocol was used aiming both at scale-up ease and at stronger coupling between chitosan and SLNs. The resulting particles were chitosan associated-SLNs (CS-SLNs)...
January 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27885272/driver-mutations-effect-in-secondary-myelofibrosis-an-international-multicenter-study-based-on-781-patients
#5
F Passamonti, B Mora, T Giorgino, P Guglielmelli, M Cazzola, M Maffioli, A Rambaldi, M Caramella, R Komrokji, J Gotlib, J J Kiladjian, F Cervantes, T Devos, F Palandri, V De Stefano, M Ruggeri, R Silver, G Benevolo, F Albano, D Caramazza, E Rumi, M Merli, D Pietra, R Casalone, T Barbui, L Pieri, A M Vannucchi
No abstract text is available yet for this article.
January 3, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27830869/atlas-occipitalization-associated-with-other-anomalies-in-a-16th-century-skeleton-from-sardinia-italy
#6
Valentina Giuffra, Andrea Montella, Marco Milanese, Eugenia Tognotti, Davide Caramella, Pasquale Bandiera
Archaeological excavations carried out in the plague cemetery of 16th century Alghero (Sardinia) brought to light the skeleton of a male aged 35-45 years, showing anomalies of the atlas. A macroscopic and radiological study has been carried out. The first cervical vertebra is fused with the skull base, resulting in an occipitalization of the atlas. Absence of the costal element of the left foramen trasversarium, resulting in an open anterior foramen trasversarium, and posterior arch defect are also observed...
November 10, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27789370/application-of-doe-approach-in-the-development-of-mini-capsules-based-on-biopolymers-and-manuka-honey-polar-fraction-as-powder-formulation-for-the-treatment-of-skin-ulcers
#7
Marika Tenci, Silvia Rossi, Maria Cristina Bonferoni, Giuseppina Sandri, Irene Mentori, Cinzia Boselli, Antonia Icaro Cornaglia, Maria Daglia, Anna Marchese, Carla Caramella, Franca Ferrari
The aim of the present work was the development of a powder formulation for the delivery of manuka honey (MH) bioactive components in the treatment of chronic skin ulcers. In particular pectin (PEC)/chitosan glutamate (CS)/hyaluronic acid (HA) mini-capsules were obtained by inverse ionotropic gelation in presence of calcium chloride and subsequently freeze-dried. Optimization of unloaded (blank) formulation was performed using DoE approach. In a screening phase, the following three factors were investigated at two levels: CS (0...
January 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27626634/from-cortical-and-subcortical-grey-matter-abnormalities-to-neurobehavioral-phenotype-of-angelman-syndrome-a-voxel-based-morphometry-study
#8
Gayane Aghakhanyan, Paolo Bonanni, Giovanna Randazzo, Sara Nappi, Federica Tessarotto, Lara De Martin, Francesca Frijia, Daniele De Marchi, Francesco De Masi, Beate Kuppers, Francesco Lombardo, Davide Caramella, Domenico Montanaro
Angelman syndrome (AS) is a rare neurogenetic disorder due to loss of expression of maternal ubiquitin-protein ligase E3A (UBE3A) gene. It is characterized by severe developmental delay, speech impairment, movement or balance disorder and typical behavioral uniqueness. Affected individuals show normal magnetic resonance imaging (MRI) findings, although mild dysmyelination may be observed. In this study, we adopted a quantitative MRI analysis with voxel-based morphometry (FSL-VBM) method to investigate disease-related changes in the cortical/subcortical grey matter (GM) structures...
2016: PloS One
https://www.readbyqxmd.com/read/27553112/robotic-pancreatoduodenectomy-with-vascular-resection
#9
REVIEW
Emanuele F Kauffmann, Niccolò Napoli, Francesca Menonna, Fabio Vistoli, Gabriella Amorese, Daniela Campani, Luca Emanuele Pollina, Niccola Funel, Carla Cappelli, Davide Caramella, Ugo Boggi
PURPOSE: This study aims to define the current status of robotic pancreatoduodenectomy (RPD) with resection and reconstruction of the superior mesenteric/portal vein (RPD-SMV/PV). METHODS: Our experience on RPD, including RPD-SMV/PV, is presented along with a description of the surgical technique and a systematic review of the literature on RPD-SMV/PV. RESULTS: We have performed 116 RPD and 14 RPD-SMV/PV. Seven additional cases of RPD-SMV/PV were identified in the literature...
December 2016: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/27544055/brain-radionecrosis-treated-with-bevacizumab-in-a-patient-with-resected-squamous-cell-carcinoma-of%C3%A2-the-lung
#10
Jordi Remon, Cécile Le Péchoux, Caroline Caramella, Frederic Dhermain, Guillame Louvel, Jean-Charles Soria, Benjamin Besse
No abstract text is available yet for this article.
January 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27508212/thrombosis-of-kommerell-s-diverticulum-with-subclavian-steal-phenomenon-in-a-patient-with-non-small-cell-lung-carcinoma-under-chemotherapy
#11
Lorenzo Faggioni, Michela Gabelloni, Vinicio Napoli, Francesco Iorio, Antonio Chella, Davide Caramella
Kommerell's diverticulum (KD) is defined as a bulbous dilatation of the origin of an aberrant subclavian artery due to a remnant of the left fourth aortic arch. We report the case of an asymptomatic woman in whom progressive thrombosis of the KD extending to the prevertebral tract of an aberrant right subclavian artery was detected at multidetector computed tomography imaging for lung cancer staging performed before and after the beginning of chemotherapy. Reversed blood flow in the ipsilateral vertebral artery due to subclavian steal phenomenon was also observed by color Doppler ultrasound examination...
2016: European Journal of Radiology Open
https://www.readbyqxmd.com/read/27459366/computational-mechanistic-study-of-thionation-of-carbonyl-compounds-with-lawesson-s-reagent
#12
L Legnani, L Toma, P Caramella, M A Chiacchio, S Giofrè, I Delso, T Tejero, P Merino
The thionation reaction of carbonyl compounds with Lawesson's reagent (LR) has been studied using density functional theory methods and topological analyses. After dissociation of LR, the reaction takes place through a two-step mechanism involving (i) a concerted cycloaddition between one monomer and the carbonyl compound to form a four-membered intermediate and (ii) a cycloreversion leading to the thiocarbonyl derivative and phenyl(thioxo)phosphine oxide. Topological analyses confirmed the concertedness and asynchronicity of the process...
September 2, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27377172/role-of-perfusion-ct-in-the-evaluation-of-functional-primary-tumour-response-after-radiochemotherapy-in-head-and-neck-cancer-preliminary-findings
#13
Stefano Ursino, Lorenzo Faggioni, Federica Guidoccio, Patrizia Ferrazza, Veronica Seccia, Emanuele Neri, Luna N Cernusco, Durim Delishaj, Riccardo Morganti, Duccio Volterrani, Fabiola Paiar, Davide Caramella
OBJECTIVE: To report the initial results of a prospective study aimed at evaluating the CT perfusion parameter changes (∆PCTp) of the primary tumour after radiochemotherapy (RCT) in head and neck cancer (HNC) and to correlate with positron emission tomography (PET)/CT response. METHODS: Eligibility criteria included HNC (Stage III-IV) candidates for RCT. Patients underwent perfusion CT (PCT) at baseline and at 3 weeks and 3 months after treatment. Blood volume, blood flow, mean transit time (MTT) and permeability surface (PS) product were computed...
September 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27365292/middle-paleolithic-human-deciduous-incisor-from-grotta-del-cavallo-italy
#14
Pier Francesco Fabbri, Daniele Panetta, Lucia Sarti, Fabio Martini, Piero A Salvadori, Davide Caramella, Mariaelena Fedi, Stefano Benazzi
OBJECTIVES: In this contribution, we present a morphological description and comparative morphometric analysis of Cavallo D, a human tooth unearthed from the Mousterian FIII sublayer of Grotta del Cavallo (Apulia, Italy). MATERIALS AND METHODS: We used microCT data to provide a detailed morphological description and morphometric analysis of the Cavallo D human tooth based on traditional diameter measurements and 3D enamel thickness. Moreover, new AMS radiocarbon dating of charcoals from layers FII was carried out...
July 1, 2016: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/27313866/cationic-thiolated-poly-aspartamide-polymer-as-a-potential-excipient-for-artificial-tear-formulations
#15
Mária Budai-Szűcs, Gabriella Horvát, Barnabás Áron Szilágyi, Benjámin Gyarmati, András Szilágyi, Szilvia Berkó, Piroska Szabó-Révész, Giuseppina Sandri, Maria Cristina Bonferoni, Carla Caramella, Judit Soós, Andrea Facskó, Erzsébet Csányi
Dry eye disease is a relatively common ocular problem, which causes eye discomfort and visual disorders leading to a decrease in the quality of life. The aim of this study was to find a possible excipient for eye drop formulations, which is able to stabilize the tear film. A cationic thiolated polyaspartamide polymer, poly[(N-mercaptoethylaspartamide)-co-(N-(N',N'-dimethylaminoethyl)aspartamide)] (ThioPASP-DME), was used as a potential vehicle. Besides satisfying the basic requirements, the chemical structure of ThioPASP-DME is similar to those of ocular mucins as it is a protein-like polymer bearing a considerable number of thiol groups...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27301186/palmitoyl-glycol-chitosan-micelles-for-corneal-delivery-of-cyclosporine
#16
M C Bonferoni, G Sandri, E Dellera, S Rossi, F Ferrari, Y Zambito, C Caramella
Different substitution degrees of palmitoyl glycol chitosan (PGC), prepared according to the literature, were used to obtain polymeric micelles that have been assessed in comparison with Pluronic F127 micelles as possible carriers for poorly soluble drugs, such as cyclosporine A. Both PGC and Pluronic micelles were studied for their interactions with cell culture substrates. The least substituted and most hydrophilic derivative, PGC21 (approximately 5% substitution), showed a strong association with cyclosporine, more than tripling the colloidal concentration with respect to the saturated solution...
January 2016: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/27234702/platelet-lysate-and-chondroitin-sulfate-loaded-contact-lenses-to-heal-corneal-lesions
#17
Giuseppina Sandri, Maria Cristina Bonferoni, Silvia Rossi, Alessio Delfino, Federica Riva, Antonia Icaro Cornaglia, Giorgio Marrubini, Giorgio Musitelli, Claudia Del Fante, Cesare Perotti, Carla Caramella, Franca Ferrari
Hemoderivative tear substitutes contain various ephiteliotrophic factors, such as growth factors (GF), involved in ocular surface homeostasis without immunogenic properties. The aim of the present work was the loading of platelet lysate into contact lenses to improve the precorneal permanence of platelet lysate growth factors on the ocular surface to enhance the treatment of corneal lesions. To this purpose, chondroitin sulfate, a sulfated glycosaminoglycan, which is normally present in the extracellular matrix, was associated with platelet lysate...
July 25, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27215534/particulate-systems-based-on-pectin-chitosan-association-for-the-delivery-of-manuka-honey-components-and-platelet-lysate-in-chronic-skin-ulcers
#18
Marika Tenci, Silvia Rossi, Maria Cristina Bonferoni, Giuseppina Sandri, Cinzia Boselli, Arianna Di Lorenzo, Maria Daglia, Antonia Icaro Cornaglia, Luciana Gioglio, Cesare Perotti, Carla Caramella, Franca Ferrari
The aim of the present work was the development of a powder formulation for the delivery of manuka honey (MH) bioactive components and platelet lysate (PL) in chronic skin ulcers. In particular pectin (PEC)/chitosan (CS) particles were prepared by ionotropic gelation in the presence of calcium chloride and subsequently characterized for particle size, hydration properties and mechanical resistance. Different experimental conditions (calcium chloride and CS concentrations; rest time in the cationic solution) were considered in order to obtain particles characterized by optimal size, hydration properties and mechanical resistance...
July 25, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27197808/crizotinib-primary-resistance-overcome-by-ceritinib-in-a-patient-with-alk-rearranged-non-small-cell-lung-cancer
#19
Francesco Facchinetti, Caroline Caramella, Nathalie Auger, David Planchard, Julien Adam, Ludovic Lacroix, Jordi Remon, Christophe Massard, Jean-Charles Soria, Luc Friboulet, Benjamin Besse
We report on the case of a patient affected by advanced non-small cell lung cancer (NSCLC) harboring an anaplastic lymphoma kinase (ALK) gene rearrangement who did not respond to crizotinib but subsequently benefited from treatment with ceritinib (LDK378). Although second-generation ALK inhibitors have shown activity in patients pretreated with crizotinib who experienced secondary resistance, this is the first report to date describing their efficacy in a case of primary resistance. Of note, none of the previously described molecular mechanisms explaining resistance to crizotinib was detected on either the initial or post-crizotinib biopsies...
November 11, 2016: Tumori
https://www.readbyqxmd.com/read/27070541/how-does-radiotherapy-impact-swallowing-function-in-nasopharynx-and-oropharynx-cancer-short-term-results-of-a-prospective-study
#20
S Ursino, V Seccia, P Cocuzza, P Ferrazza, T Briganti, F Matteucci, L Fatigante, P Giusti, M Grosso, L Locantore, R Morganti, A Nacci, S Sellari Franceschini, F Paiar, D Caramella, B Fattori
The objective of this study is to report the initial results of a prospective trial assessing instrumental deglutition function in nasopharynx and oropharynx cancers after radio or chemoradiotherapy using intensity-modulated radiotherapy (IMRT). IMRT was delivered aiming to spare the swallowing organ at risk (SWOARs) for Stage II-IV naso- and oropharynx cancer. Objective instrumental assessment included videofluoroscopy (VFS), fiberoptic endoscopic evaluation of swallowing (FEES) and oro-pharyngeal-oesophageal scintigraphy (OPES) at baseline and at 1 month after radiotherapy...
June 2016: Acta Otorhinolaryngologica Italica
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