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https://www.readbyqxmd.com/read/27885272/driver-mutations-effect-in-secondary-myelofibrosis-an-international-multicenter-study-based-on-781-patients
#1
F Passamonti, B Mora, T Giorgino, P Guglielmelli, M Cazzola, M Maffioli, A Rambaldi, M Caramella, R Komrokji, J Gotlib, J J Kiladjian, F Cervantes, T Devos, F Palandri, V De Stefano, M Ruggeri, R Silver, G Benevolo, F Albano, D Caramazza, E Rumi, M Merli, D Pietra, R Casalone, T Barbui, L Pieri, A M Vannucchi
Leukemia accepted article preview online, 25 November 2016. doi:10.1038/leu.2016.351.
November 25, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27830869/atlas-occipitalization-associated-with-other-anomalies-in-a-16th-century-skeleton-from-sardinia-italy
#2
Valentina Giuffra, Andrea Montella, Marco Milanese, Eugenia Tognotti, Davide Caramella, Pasquale Bandiera
Archaeological excavations carried out in the plague cemetery of 16th century Alghero (Sardinia) brought to light the skeleton of a male aged 35-45 years, showing anomalies of the atlas. A macroscopic and radiological study has been carried out. The first cervical vertebra is fused with the skull base, resulting in an occipitalization of the atlas. Absence of the costal element of the left foramen trasversarium, resulting in an open anterior foramen trasversarium, and posterior arch defect are also observed...
November 10, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27789370/application-of-doe-approach-in-the-development-of-mini-capsules-based-on-biopolymers-and-manuka-honey-polar-fraction-as-powder-formulation-for-the-treatment-of-skin-ulcers
#3
Marika Tenci, Silvia Rossi, Maria Cristina Bonferoni, Giuseppina Sandri, Irene Mentori, Cinzia Boselli, Antonia Icaro Cornaglia, Maria Daglia, Anna Marchese, Carla Caramella, Franca Ferrari
The aim of the present work was the development of a powder formulation for the delivery of manuka honey (MH) bioactive components in the treatment of chronic skin ulcers. In particular pectin (PEC)/chitosan glutamate (CS)/hyaluronic acid (HA) mini-capsules were obtained by inverse ionotropic gelation in presence of calcium chloride and subsequently freeze-dried. Optimization of unloaded (blank) formulation was performed using DoE approach. In a screening phase, the following three factors were investigated at two levels: CS (0...
October 24, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27626634/from-cortical-and-subcortical-grey-matter-abnormalities-to-neurobehavioral-phenotype-of-angelman-syndrome-a-voxel-based-morphometry-study
#4
Gayane Aghakhanyan, Paolo Bonanni, Giovanna Randazzo, Sara Nappi, Federica Tessarotto, Lara De Martin, Francesca Frijia, Daniele De Marchi, Francesco De Masi, Beate Kuppers, Francesco Lombardo, Davide Caramella, Domenico Montanaro
Angelman syndrome (AS) is a rare neurogenetic disorder due to loss of expression of maternal ubiquitin-protein ligase E3A (UBE3A) gene. It is characterized by severe developmental delay, speech impairment, movement or balance disorder and typical behavioral uniqueness. Affected individuals show normal magnetic resonance imaging (MRI) findings, although mild dysmyelination may be observed. In this study, we adopted a quantitative MRI analysis with voxel-based morphometry (FSL-VBM) method to investigate disease-related changes in the cortical/subcortical grey matter (GM) structures...
2016: PloS One
https://www.readbyqxmd.com/read/27553112/robotic-pancreatoduodenectomy-with-vascular-resection
#5
Emanuele F Kauffmann, Niccolò Napoli, Francesca Menonna, Fabio Vistoli, Gabriella Amorese, Daniela Campani, Luca Emanuele Pollina, Niccola Funel, Carla Cappelli, Davide Caramella, Ugo Boggi
PURPOSE: This study aims to define the current status of robotic pancreatoduodenectomy (RPD) with resection and reconstruction of the superior mesenteric/portal vein (RPD-SMV/PV). METHODS: Our experience on RPD, including RPD-SMV/PV, is presented along with a description of the surgical technique and a systematic review of the literature on RPD-SMV/PV. RESULTS: We have performed 116 RPD and 14 RPD-SMV/PV. Seven additional cases of RPD-SMV/PV were identified in the literature...
August 24, 2016: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/27544055/brain-radionecrosis-treated-with-bevacizumab-in-a-patient-with-resected-squamous-cell-carcinoma-of-the-lung
#6
Jordi Remon, Cécile Le Péchoux, Caroline Caramella, Frederic Dhermain, Guillame Louvel, Jean-Charles Soria, Benjamin Besse
No abstract text is available yet for this article.
August 17, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27508212/thrombosis-of-kommerell-s-diverticulum-with-subclavian-steal-phenomenon-in-a-patient-with-non-small-cell-lung-carcinoma-under-chemotherapy
#7
Lorenzo Faggioni, Michela Gabelloni, Vinicio Napoli, Francesco Iorio, Antonio Chella, Davide Caramella
Kommerell's diverticulum (KD) is defined as a bulbous dilatation of the origin of an aberrant subclavian artery due to a remnant of the left fourth aortic arch. We report the case of an asymptomatic woman in whom progressive thrombosis of the KD extending to the prevertebral tract of an aberrant right subclavian artery was detected at multidetector computed tomography imaging for lung cancer staging performed before and after the beginning of chemotherapy. Reversed blood flow in the ipsilateral vertebral artery due to subclavian steal phenomenon was also observed by color Doppler ultrasound examination...
2016: European Journal of Radiology Open
https://www.readbyqxmd.com/read/27459366/computational-mechanistic-study-of-thionation-of-carbonyl-compounds-with-lawesson-s-reagent
#8
L Legnani, L Toma, P Caramella, M A Chiacchio, S Giofrè, I Delso, T Tejero, P Merino
The thionation reaction of carbonyl compounds with Lawesson's reagent (LR) has been studied using density functional theory methods and topological analyses. After dissociation of LR, the reaction takes place through a two-step mechanism involving (i) a concerted cycloaddition between one monomer and the carbonyl compound to form a four-membered intermediate and (ii) a cycloreversion leading to the thiocarbonyl derivative and phenyl(thioxo)phosphine oxide. Topological analyses confirmed the concertedness and asynchronicity of the process...
September 2, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27377172/role-of-perfusion-ct-in-the-evaluation-of-functional-primary-tumour-response-after-radiochemotherapy-in-head-and-neck-cancer-preliminary-findings
#9
Stefano Ursino, Lorenzo Faggioni, Federica Guidoccio, Patrizia Ferrazza, Veronica Seccia, Emanuele Neri, Luna N Cernusco, Durim Delishaj, Riccardo Morganti, Duccio Volterrani, Fabiola Paiar, Davide Caramella
OBJECTIVE: To report the initial results of a prospective study aimed at evaluating the CT perfusion parameter changes (∆PCTp) of the primary tumour after radiochemotherapy (RCT) in head and neck cancer (HNC) and to correlate with positron emission tomography (PET)/CT response. METHODS: Eligibility criteria included HNC (Stage III-IV) candidates for RCT. Patients underwent perfusion CT (PCT) at baseline and at 3 weeks and 3 months after treatment. Blood volume, blood flow, mean transit time (MTT) and permeability surface (PS) product were computed...
September 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27365292/middle-paleolithic-human-deciduous-incisor-from-grotta-del-cavallo-italy
#10
Pier Francesco Fabbri, Daniele Panetta, Lucia Sarti, Fabio Martini, Piero A Salvadori, Davide Caramella, Mariaelena Fedi, Stefano Benazzi
OBJECTIVES: In this contribution, we present a morphological description and comparative morphometric analysis of Cavallo D, a human tooth unearthed from the Mousterian FIII sublayer of Grotta del Cavallo (Apulia, Italy). MATERIALS AND METHODS: We used microCT data to provide a detailed morphological description and morphometric analysis of the Cavallo D human tooth based on traditional diameter measurements and 3D enamel thickness. Moreover, new AMS radiocarbon dating of charcoals from layers FII was carried out...
July 1, 2016: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/27313866/cationic-thiolated-poly-aspartamide-polymer-as-a-potential-excipient-for-artificial-tear-formulations
#11
Mária Budai-Szűcs, Gabriella Horvát, Barnabás Áron Szilágyi, Benjámin Gyarmati, András Szilágyi, Szilvia Berkó, Piroska Szabó-Révész, Giuseppina Sandri, Maria Cristina Bonferoni, Carla Caramella, Judit Soós, Andrea Facskó, Erzsébet Csányi
Dry eye disease is a relatively common ocular problem, which causes eye discomfort and visual disorders leading to a decrease in the quality of life. The aim of this study was to find a possible excipient for eye drop formulations, which is able to stabilize the tear film. A cationic thiolated polyaspartamide polymer, poly[(N-mercaptoethylaspartamide)-co-(N-(N',N'-dimethylaminoethyl)aspartamide)] (ThioPASP-DME), was used as a potential vehicle. Besides satisfying the basic requirements, the chemical structure of ThioPASP-DME is similar to those of ocular mucins as it is a protein-like polymer bearing a considerable number of thiol groups...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27301186/palmitoyl-glycol-chitosan-micelles-for-corneal-delivery-of-cyclosporine
#12
M C Bonferoni, G Sandri, E Dellera, S Rossi, F Ferrari, Y Zambito, C Caramella
Different substitution degrees of palmitoyl glycol chitosan (PGC), prepared according to the literature, were used to obtain polymeric micelles that have been assessed in comparison with Pluronic F127 micelles as possible carriers for poorly soluble drugs, such as cyclosporine A. Both PGC and Pluronic micelles were studied for their interactions with cell culture substrates. The least substituted and most hydrophilic derivative, PGC21 (approximately 5% substitution), showed a strong association with cyclosporine, more than tripling the colloidal concentration with respect to the saturated solution...
January 2016: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/27234702/platelet-lysate-and-chondroitin-sulfate-loaded-contact-lenses-to-heal-corneal-lesions
#13
Giuseppina Sandri, Maria Cristina Bonferoni, Silvia Rossi, Alessio Delfino, Federica Riva, Antonia Icaro Cornaglia, Giorgio Marrubini, Giorgio Musitelli, Claudia Del Fante, Cesare Perotti, Carla Caramella, Franca Ferrari
Hemoderivative tear substitutes contain various ephiteliotrophic factors, such as growth factors (GF), involved in ocular surface homeostasis without immunogenic properties. The aim of the present work was the loading of platelet lysate into contact lenses to improve the precorneal permanence of platelet lysate growth factors on the ocular surface to enhance the treatment of corneal lesions. To this purpose, chondroitin sulfate, a sulfated glycosaminoglycan, which is normally present in the extracellular matrix, was associated with platelet lysate...
July 25, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27215534/particulate-systems-based-on-pectin-chitosan-association-for-the-delivery-of-manuka-honey-components-and-platelet-lysate-in-chronic-skin-ulcers
#14
Marika Tenci, Silvia Rossi, Maria Cristina Bonferoni, Giuseppina Sandri, Cinzia Boselli, Arianna Di Lorenzo, Maria Daglia, Antonia Icaro Cornaglia, Luciana Gioglio, Cesare Perotti, Carla Caramella, Franca Ferrari
The aim of the present work was the development of a powder formulation for the delivery of manuka honey (MH) bioactive components and platelet lysate (PL) in chronic skin ulcers. In particular pectin (PEC)/chitosan (CS) particles were prepared by ionotropic gelation in the presence of calcium chloride and subsequently characterized for particle size, hydration properties and mechanical resistance. Different experimental conditions (calcium chloride and CS concentrations; rest time in the cationic solution) were considered in order to obtain particles characterized by optimal size, hydration properties and mechanical resistance...
July 25, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27197808/crizotinib-primary-resistance-overcome-by-ceritinib-in-a-patient-with-alk-rearranged-non-small-cell-lung-cancer
#15
Francesco Facchinetti, Caroline Caramella, Nathalie Auger, David Planchard, Julien Adam, Ludovic Lacroix, Jordi Remon, Christophe Massard, Jean-Charles Soria, Luc Friboulet, Benjamin Besse
We report on the case of a patient affected by advanced non-small cell lung cancer (NSCLC) harboring an anaplastic lymphoma kinase (ALK) gene rearrangement who did not respond to crizotinib but subsequently benefited from treatment with ceritinib (LDK378). Although second-generation ALK inhibitors have shown activity in patients pretreated with crizotinib who experienced secondary resistance, this is the first report to date describing their efficacy in a case of primary resistance. Of note, none of the previously described molecular mechanisms explaining resistance to crizotinib was detected on either the initial or post-crizotinib biopsies...
May 13, 2016: Tumori
https://www.readbyqxmd.com/read/27070541/how-does-radiotherapy-impact-swallowing-function-in-nasopharynx-and-oropharynx-cancer-short-term-results-of-a-prospective-study
#16
S Ursino, V Seccia, P Cocuzza, P Ferrazza, T Briganti, F Matteucci, L Fatigante, P Giusti, M Grosso, L Locantore, R Morganti, A Nacci, S Sellari Franceschini, F Paiar, D Caramella, B Fattori
The objective of this study is to report the initial results of a prospective trial assessing instrumental deglutition function in nasopharynx and oropharynx cancers after radio or chemoradiotherapy using intensity-modulated radiotherapy (IMRT). IMRT was delivered aiming to spare the swallowing organ at risk (SWOARs) for Stage II-IV naso- and oropharynx cancer. Objective instrumental assessment included videofluoroscopy (VFS), fiberoptic endoscopic evaluation of swallowing (FEES) and oro-pharyngeal-oesophageal scintigraphy (OPES) at baseline and at 1 month after radiotherapy...
June 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27029729/-analytical-performances-of-real-time-pcr-by-abbott-realtime-cmv-with-m2000-for-the-detection-of-cytomegalovirus-in-urine
#17
Anne De Monte, Isabelle Cannavo, Anne Caramella, Laurence Ollier, Valérie Giordanengo
Congenital cytomegalovirus (CMV) infection is the leading cause of sensoneurinal disability due to infectious congenital disease. The diagnosis of congenital CMV infection is based on the search of CMV in the urine within the first two weeks of life. Viral culture of urine is the gold standard. However, the PCR is highly sensitive and faster. It is becoming an alternative choice. The objective of this study is the validation of real-time PCR by Abbott RealTime CMV with m2000 for the detection of cytomegalovirus in urine...
March 2016: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/27010101/cardiophrenic-angle-lymph-node-is-an-indicator-of-metastatic-spread-but-not-specifically-peritoneal-carcinomatosis-in-colorectal-cancer-patients-results-of-a-prospective-validation-study-in-91-patients
#18
F Jeune, A Brouquet, C Caramella, M Gayet, S Abdalla, A-L Verin, A Thirot Bidault, C Penna, S Benoist
BACKGROUND: The presence of cardiophrenic angle lymph node (CPALN) has been associated with the risk of peritoneal carcinomatosis (PC) in high risk colon cancer patients. Its accuracy to predict PC and its prognostic value in non-selected CRC patients has not been validated prospectively. METHODS: From 2011 to 2013, all patients undergoing colectomy for colon cancer were included prospectively. Presence of CPALN was assessed on preoperative computed tomography scan by two radiologists...
June 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26913749/-deep-purple-urine-bag-syndrome-physiopathology-and-clinical-implications
#19
Maria Valentina Domenech, Marta Calatroni, Pasquale Esposito, Nicoletta Serpieri, Edoardo La Porta, Luca Estienne, Elena Caramella, Antonio Dal Canton, Teresa Rampino
Urinalysis is a key part of the clinical evaluation of patients with kidney disease. It can provide several useful information for the diagnosis and management of diseases of kidneys and urinary tract. In particular, urine color can be affected by the presence of blood, infection and endogenous metabolites, such as bilirubin, or exogenous, for instance those derived from drugs. Therefore, the analysis of urine color may be helpful in identifying different clinical conditions. Here we report a case of a patient who presented purple-colored urine, the so-called " Purple urine bag syndrome", discussing the predisposing factors and the pathogenesis of this condition...
January 2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/26886338/sponge-like-dressings-based-on-the-association-of-chitosan-and-sericin-for-the-treatment-of-chronic-skin-ulcers-i-design-of-experiments-assisted-development
#20
Michela Mori, Silvia Rossi, Franca Ferrari, Maria Cristina Bonferoni, Giuseppina Sandri, Theodora Chlapanidas, Maria Luisa Torre, Carla Caramella
The aim of the present work was the development of sponge-like dressings based on chitosan glutamate (high molecular weight) and sericin for the treatment of chronic skin ulcers. Dressings were prepared by freeze-drying and glycine was added as cryoprotectant agent. Dressing development was assisted by design of experiments, using a simplex centroid design. Mechanical resistance, hydration propensity, viscous, and viscoelasticity properties of dressings were considered as response variables. The superimposition of the contour plots, calculated by the best fit model for each response variable, permitted to individuate a region of the factor space where the dressing of optimized quantitative composition was chosen...
March 2016: Journal of Pharmaceutical Sciences
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