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https://www.readbyqxmd.com/read/29737491/computed-tomography-imaging-with-the-adaptive-statistical-iterative-reconstruction-asir-algorithm-dependence-of-image-quality-on-the-blending-level-of-reconstruction
#1
Patrizio Barca, Marco Giannelli, Maria Evelina Fantacci, Davide Caramella
Computed tomography (CT) is a useful and widely employed imaging technique, which represents the largest source of population exposure to ionizing radiation in industrialized countries. Adaptive Statistical Iterative Reconstruction (ASIR) is an iterative reconstruction algorithm with the potential to allow reduction of radiation exposure while preserving diagnostic information. The aim of this phantom study was to assess the performance of ASIR, in terms of a number of image quality indices, when different reconstruction blending levels are employed...
May 8, 2018: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/29729636/rheological-analysis-and-mucoadhesion-a-30-year-old-and-still-active-combination
#2
REVIEW
Silvia Rossi, Barbara Vigani, Maria Cristina Bonferoni, Giuseppina Sandri, Carla Caramella, Franca Ferrari
At the end of 80s and in the early 90s, an increasing interest in the development of mucoadhesive formulations occurred in the pharmaceutical field. Such formulations, prolonging the drug permanence on the mucosa of action/absorption, improve drug availability/bioavailability and therefore its therapeutic effectiveness. Among the various methods reported in the literature for the evaluation of the mucoadhesive properties of polymers, in the early 1990s, the study of the rheological variation of the polymer solutions after mixing with a mucin solution/dispersion has been proposed as an approach to measure the strength of the mucoadhesive joint...
April 25, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29687416/mrecist-criteria-to-assess-recurrent-thyroid-carcinoma-treatment-response-after-radiofrequency-ablation-a-prospective-study
#3
S Mazzeo, R Cervelli, R Elisei, G Tarantini, C Cappelli, E Molinaro, D Galleri, L De Napoli, C Comite, R Cioni, P Vitti, D Caramella
PURPOSE: Surgical removal is recommended for recurrent thyroid carcinomas (RTCs) unable to uptake radioiodine and/or not responsive to chemotherapy. However, repeated neck dissection is difficult for surgeons. Thus, radiofrequency ablation (RFA) was proposed for RTCs. The aim of this prospective study is to assess RTC treatment response after RFA, according to well-established criteria. METHODS: Sixteen lesions in 13 patients were treated by RFA. All patients refused/were excluded from repeated surgery or other conventional therapy...
April 23, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29622658/value-of-cytogenetic-abnormalities-in-post-polycythemia-vera-and-post-essential-thrombocythemia-myelofibrosis-a-study-of-the-mysec-project
#4
Barbara Mora, Toni Giorgino, Paola Guglielmelli, Elisa Rumi, Margherita Maffioli, Alessandro Rambaldi, Marianna Caramella, Rami Komrokji, Jason Gotlib, Jean-Jacques Kiladjian, Francisco Cervantes, Timothy Devos, Francesca Palandri, Valerio De Stefano, Marco Ruggeri, Richard T Silver, Giulia Benevolo, Francesco Albano, Chiara Cavalloni, Daniela Barraco, Michele Merli, Daniela Pietra, Rosario Casalone, Tiziano Barbui, Giada Rotunno, Mario Cazzola, Alessandro Maria Vannucchi, Francesco Passamonti
No abstract text is available yet for this article.
April 5, 2018: Haematologica
https://www.readbyqxmd.com/read/29616377/male-secretory-breast-cancer-case-in-a-6-year-old-boy-with-a-peculiar-gene-duplication-and-review-of-the-literature
#5
REVIEW
M Ghilli, M D Mariniello, C Scatena, L Dosa, G Traficante, A Tamburini, C Caporalini, A M Buccoliero, F Facchini, L Colizzi, A Quattrini Li, E Landucci, G Manca, A G Naccarato, D Caramella, C Favre, M Roncella
PURPOSE: Secretory breast cancer (SBC) is one of the rarest breast cancer (BC), representing the majority of BC in childhood. Nevertheless, it elicits a lot of interest both for the peculiar morphology and the characteristic genetic features. Currently, there is no consensus on optimal treatment strategy. Therefore, it is useful to report every case in order to establish treatment algorithms. METHODS: We describe the case of a 6-year-old boy diagnosed with a SBC, with peculiar genomic and immunohistochemical features...
April 3, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29574078/a-novel-dressing-for-the-combined-delivery-of-platelet-lysate-and-vancomycin-hydrochloride-to-chronic-skin-ulcers-hyaluronic-acid-particles-in-alginate-matrices
#6
S Rossi, M Mori, B Vigani, M C Bonferoni, G Sandri, F Riva, C Caramella, F Ferrari
The aim of the present work was to develop a medication allowing for the combined delivery of platelet lysate (PL) and an anti-infective model drug, vancomycin hydrochloride (VCM), to chronic skin ulcers. A simple method was set up for the preparation of hyaluronic acid (HA) core-shell particles, loaded with PL and coated with calcium alginate, embedded in a VCM containing alginate matrix. Two different CaCl2 concentrations were investigated to allow for HA/PL core-shell particle formation. The resulting dressings were characterized for mechanical and hydration properties and tested in vitro (on fibroblasts) and ex-vivo (on skin biopsies) for biological activity...
March 21, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29490941/olfactory-dysfunction-is-worse-in-primary-ciliary-dyskinesia-compared-with-other-causes-of-chronic-sinusitis-in-children
#7
Massimo Pifferi, Andrew Bush, Michele Rizzo, Alessandro Tonacci, Maria Di Cicco, Martina Piras, Fabrizio Maggi, Giulia Paiola, Angela Michelucci, Angela Cangiotti, Diego Peroni, Davide Caramella, Attilio L Boner
Cilia have multiple functions including olfaction. We hypothesised that olfactory function could be impaired in primary ciliary dyskinesia (PCD). Olfaction, nasal nitric oxide (nNO) and sinus CT were assessed in patients with PCD and non-PCD sinus disease, and healthy controls (no CT scan). PCD and non-PCD patients had similar severity of sinus disease. Despite this, defective olfaction was more common in patients with PCD (P<0.0001) and more severe in patients with PCD with major Transmission Electron Microscopy (TEM) abnormalities...
February 28, 2018: Thorax
https://www.readbyqxmd.com/read/29461958/gout-in-duke-federico-of-montefeltro-1422-1482-a-new-pearl-of-the-italian-renaissance
#8
Antonio Fornaciari, Valentina Giuffra, Emanuele Armocida, Davide Caramella, Frank J Rühli, Francesco Maria Galassi
The article examines the truthfulness of historical accounts claiming that Renaissance Duke Federico of Montefeltro (1422-1482) suffered from gout. By direct paleopathological assessment of the skeletal remains and by the philological investigation of historical and documental sources, primarily a 1461 handwritten letter by the Duke himself to his personal physician, a description of the symptoms and Renaissance therapy is offered and a final diagnosis of gout is formulated. The Duke's handwritten letter offers a rare testimony of ancient clinical self-diagnostics and Renaissance living-experience of gout...
January 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29443389/can-we-trust-the-calculation-of-texture-indices-of-ct-images-a-phantom-study
#9
Caroline Caramella, Adrien Allorant, Fanny Orlhac, Francois Bidault, Bernard Asselain, Samy Ammari, Patricia Jaranowski, Aurelie Moussier, Corinne Balleyguier, Nathalie Lassau, Stephanie Pitre-Champagnat
PURPOSE: Texture analysis is an emerging tool in the field of medical imaging analysis. However, many issues have been raised in terms of its use in assessing patient images and it is crucial to harmonize and standardize this new imaging measurement tool. This study was designed to evaluate the reliability of texture indices of CT images on a phantom including a reproducibility study, to assess the discriminatory capacity of indices potentially relevant in CT medical images and to determine their redundancy...
April 2018: Medical Physics
https://www.readbyqxmd.com/read/29425164/association-of-alpha-tocopherol-and-ag-sulfadiazine-chitosan-oleate-nanocarriers-in-bioactive-dressings-supporting-platelet-lysate-application-to-skin-wounds
#10
Maria Cristina Bonferoni, Giuseppina Sandri, Silvia Rossi, Eleonora Dellera, Alessandro Invernizzi, Cinzia Boselli, Antonia Icaro Cornaglia, Claudia Del Fante, Cesare Perotti, Barbara Vigani, Federica Riva, Carla Caramella, Franca Ferrari
Chitosan oleate was previously proposed to encapsulate in nanocarriers some poorly soluble molecules aimed to wound therapy, such as the anti-infective silver sulfadiazine, and the antioxidant α tocopherol. Because nanocarriers need a suitable formulation to be administered to wounds, in the present paper, these previously developed nanocarriers were loaded into freeze dried dressings based on chitosan glutamate. These were proposed as bioactive dressings aimed to support the application to wounds of platelet lysate, a hemoderivative rich in growth factors...
February 9, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29416740/prognostic-value-of-histogram-analysis-in-advanced-non-small-cell-lung-cancer-a-radiomic-study
#11
Bluthgen Maria Virginia, Faivre Laura, Rosellini Silvia, Ferrara Roberto, Facchinetti Francesco, Haspinger Eva, Ferte Charles, Ammari Samy, Michiels Stefan, Soria Jean-Charles, Caramella Caroline, Besse Benjamin
Introduction: Quantitative assessment of heterogeneity by histogram analysis (HA) of tumor images can potentially provide a non-invasive prognostic biomarker. We assessed the prognostic value of HA and evaluated a correlation with molecular signature. Results: CT scans performed between July 2009 and January 2015 from 692 patients were reviewed. HA was performed on scans from 313 patients in the training dataset and 108 in the validation dataset. Median follow-up were 33...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29359240/feasibility-of-percutaneous-intrahepatic-split-by-microwave-ablation-pisa-after-portal-vein-embolization-for-hypertrophy-of-future-liver-remnant-the-radiological-stage-1-alpps
#12
Alessandro Lunardi, Rosa Cervelli, Duccio Volterrani, Saverio Vitali, Carlo Lombardo, Giulia Lorenzoni, Laura Crocetti, Irene Bargellini, Daniela Campani, Luca Emanuele Pollina, Roberto Cioni, Davide Caramella, Ugo Boggi
PURPOSE: To assess the feasibility of radiological stage-1 ALPPS, associating liver partition and portal vein ligation for staged hepatectomy, by combining portal vein embolization (PVE) with percutaneous intrahepatic split by ablation (PISA). MATERIALS AND METHODS: Three patients (mean age 65.0 ± 7.3 years) underwent PVE and PISA. PISA was performed 21 days after PVE by microwave ablation to create a continuous intrahepatic cutting plane. Abdominal CT examinations were performed before and after PVE and PISA...
May 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29352936/freeze-dried-chitosan-acetate-dressings-with-glycosaminoglycans-and-traxenamic-acid
#13
Francesca Saporito, Giuseppina Sandri, Silvia Rossi, Maria Cristina Bonferoni, Federica Riva, Lorenzo Malavasi, Carla Caramella, Franca Ferrari
Bleeding control plays an important role to increase survival in the early phase after a traumatic event. The aim of present work was the development of hemostatic sponge-like dressings based on chitosan, in association with glycosaminoglycans (GAG) (chondroitin sulfate or hyaluronic acid) and the improvement of their hemostatic performance by loading tranexamic acid (TA). The dressings were prepared by lyophilizazion and were characterized for mechanical, hydration, bioadhesion properties and morphology. Moreover, FTIR analysis was performed to understand the interactions between the different polyelectrolytes present in the dressings...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352839/the-new-frontier-of-imaging-the-micron
#14
Giacomo Aringhieri, Saverio Vitali, Piercarlo Rossi, Davide Caramella
No abstract text is available yet for this article.
January 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29240045/pier-diego-siccardi-1880-1917-and-the-clinica-del-lavoro-in-the-trench-warfare
#15
Michele Augusto Riva, Michela Caramella, Massimo Turato, Giancarlo Cesana
BACKGROUND: The year 2017 marks the centenary of the death of the Italian scientist Pier Diego Siccardi (1880-1917), one of Luigi Devoto's assistants at the "Clinica del Lavoro" in Milan. OBJECTIVES: To commemorate Siccardi and to describe the activities of the physicians of the "Clinica del Lavoro" during World War I. METHODS: A comprehensive analysis was conducted on scientific papers written by Pier Diego Siccardi and by other physicians belonging to the Clinica del Lavoro, in the period 1915-1918...
December 14, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/29205793/duodenal-graft-complications-requiring-duodenectomy-after-pancreas-and-pancreas-kidney-transplantation
#16
Erica Pieroni, Niccolò Napoli, Carlo Lombardo, Piero Marchetti, Margherita Occhipinti, Carla Cappelli, Davide Caramella, Giovanni Consani, Gabriella Amorese, Maurizio De Maria, Fabio Vistoli, Ugo Boggi
Duodenal graft complications are poorly reported complications of pancreas transplantation that can result in graft loss. Excluding patients with early graft failure, after a median follow-up period of 126 months (range 23-198) duodenectomy was required in 14 of 312 pancreas transplants (4.5%). All patients were insulin-independent at the time of diagnosis. Reasons for duodenectomy included delayed duodenal graft perforation (n = 10, 71.5%) and refractory duodenal graft bleeding (n = 4, 28.5%). In patients with duodenal graft bleeding, a total duodenectomy was performed...
December 4, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29191581/prognostic-value-of-hla-a2-status-in-advanced-non-small-cell-lung-cancer-patients
#17
Laura Mezquita, Melinda Charrier, Laura Faivre, Louise Dupraz, Béranger Lueza, Jordi Remon, David Planchard, Maria Virginia Bluthgen, Francesco Facchinetti, Arslane Rahal, Valentina Polo, Anas Gazzah, Caroline Caramella, Julien Adam, Jean Pierre Pignon, Jean-Charles Soria, Nathalie Chaput, Benjamin Besse
INTRODUCTION: The class I human leucocyte antigen (HLA) molecules play a critical role as an escape mechanism of antitumoral immunity. HLA-A2 status has been evaluated as a prognostic factor in lung cancer, mostly in localized disease and with inconsistent findings. We evaluated the role of HLA-A2 status as a prognostic factor in a large and homogeneus cohort of advanced NSCLC patients. METHODS: Advanced NSCLC patients eligible for platinum-based chemotherapy were consecutively included in a single center between October 2009 and July 2015 in the prospective MSN study (NCT02105168)...
October 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29182990/patterns-of-responses-in-metastatic-nsclc-during-pd-1-or-pdl-1-inhibitor-therapy-comparison-of-recist-1-1-irrecist-and-irecist-criteria
#18
M Tazdait, L Mezquita, J Lahmar, R Ferrara, F Bidault, S Ammari, C Balleyguier, D Planchard, A Gazzah, J C Soria, A Marabelle, B Besse, C Caramella
BACKGROUND: Immune checkpoint inhibitors are an important tool in the therapeutic strategy against metastatic non-small cell lung cancer (NSCLC); however, radiological evaluation is challenging due to the emergence of atypical patterns of responses. Several evaluation criteria have been proposed, such as the Response Evaluation Criteria in Solid Tumours (RECIST), version 1.1, immune -related RECIST (irRECIST) and iRECIST, but have not been systematically compared in a homogeneous population...
January 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29166754/advances-in-oncological-treatment-limitations-of-recist-1-1-criteria
#19
Serena Grimaldi, Marie Terroir, Caroline Caramella
INTRODUCTION: RECIST 1.1 criteria are the standard for the response assessment of most solid tumors on computed tomography (CT). Nevertheless, the emergence of new classes of treatment in the lasts decades has brought new challenges in the response evaluation. EVIDENCE ACQUISITION: A PubMed online database literature search was performed in order to identify papers in English with full text available published up to September 2017. EVIDENCE SYNTHESIS: Some oncologic treatments, such as anti-angiogenic agents, immunotherapy and local treatments, have proven to be effective despite atypical patterns of responses...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29164573/role-of-perfusion-ct-in-the-evaluation-of-metastatic-nodal-tumor-response-after-radiochemotherapy-in-head-and-neck-cancer-preliminary-findings
#20
S Ursino, L Faggioni, F Fiorica, D Delishaj, V Seccia, F Pasqualetti, I Desideri, C Colosimo, R Morganti, F Paiar, D Caramella
OBJECTIVE: To assess changes of CT perfusion parameters (ΔPCTp) of cervical lymph node metastases from head and neck cancer (HNC) before and after radiochemotherapy (RT-CT) and their association with nodal tumor persistence. PATIENTS AND METHODS: Eligibility criteria included HNC (Stage III-IV) candidates for RT-CT. Patients underwent perfusion CT (PCT) at baseline 3 weeks and 3 months after RT-CT. Blood volume (BV), blood flow (BF), mean transit time (MTT) and permeability surface (PS) were calculated...
November 2017: European Review for Medical and Pharmacological Sciences
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