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https://www.readbyqxmd.com/read/28731399/expanding-the-endoscopic-transpterygoid-corridor-to-the-petroclival-region-anatomical-study-and-volumetric-comparative-analysis
#1
Jacob L Freeman, Raghuram Sampath, Steven Craig Quattlebaum, Michael A Casey, Zach A Folzenlogen, Vijay R Ramakrishnan, A Samy Youssef
OBJECTIVE The endoscopic endonasal transmaxillary transpterygoid (TMTP) approach has been the gateway for lateral skull base exposure. Removal of the cartilaginous eustachian tube (ET) and lateral mobilization of the internal carotid artery (ICA) are technically demanding adjunctive steps that are used to access the petroclival region. The gained expansion of the deep working corridor provided by these maneuvers has yet to be quantified. METHODS The TMTP approach with cartilaginous ET removal and ICA mobilization was performed in 5 adult cadaveric heads (10 sides)...
July 21, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28727952/time-resolved-laser-induced-fluorescence-spectroscopy-as-a-guidance-tool-for-laser-lithotripsy-of-gallbladder-stones
#2
Ali Shuaib, Jahja Kokaj, Yacoub Makdisi, Goran Pichler, Abdullah Husain, Sami Asfar
BACKGROUND AND OBJECTIVES: Although laser lithotripsy for fragmentation of gallbladder stones has been applied successfully in many clinical situations, this approach has two major limitations: (1) the potential to damage or perforate the bile duct and (2) the efficiency can be affected by the chemical composition of the gallstones. The present study evaluated the use of time-resolved laser-induced fluorescence spectroscopy to classify stone types and distinguish stone from tissue. MATERIALS AND METHODS: Ex vivo time-resolved laser-induced fluorescence analysis (excitation wavelength λex = 400 nm and emission wavelength = 450-700 nm) of 54 gallbladder stones and seven gallbladder tissue samples was conducted...
July 19, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28727797/prophylactic-supplementation-of-resveratrol-is-more-effective-than-its-therapeutic-use-against-doxorubicin-induced-cardiotoxicity
#3
Heba Samy Shoukry, Hania Ibrahim Ammar, Laila Ahmed Rashed, Maha Balegh Zikri, Ashraf Ali Shamaa, Sahar Gamal Abou Elfadl, Ejlal Abu-Al Rub, Sekaran Saravanan, Sanjiv Dhingra
Resveratrol (RSV), a polyphenolic compound and naturally occurring phytoalexin, has been reported to exert cardio-protective effects in several animal studies. However, the outcome of initial clinical trials with RSV was less effective compared to pre-clinical studies. Therefore, RSV treatment protocols need to be optimized. In this study we evaluated prophylactic versus therapeutic effect of resveratrol (RSV) in mitigating doxorubicin (Dox)-induced cardiac toxicity in rats. To investigate prophylactic effects, RSV was supplemented for 2 weeks along with Dox administration...
2017: PloS One
https://www.readbyqxmd.com/read/28725390/grazed-wet-meadows-are-sink-habitats-for-the-southern-dunlin-calidris-alpina-schinzii-due-to-nest-trampling-by-cattle
#4
Veli-Matti Pakanen, Sami Aikio, Aappo Luukkonen, Kari Koivula
The effect of habitat management is commonly evaluated by measuring population growth, which does not distinguish changes in reproductive success from changes in survival or the effects of immigration or emigration. Management has rarely been evaluated considering complete life cycle of the target organisms, including also possible negative impacts from management. We evaluated the effectiveness of cattle grazing in the restoration of coastal meadows as a breeding habitat for small and medium-sized ground-nesting birds by examining the size and demography of a southern dunlin (Calidris alpina schinzii) breeding population...
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28725139/hybrid-polymeric-matrices-for-oral-modified-release-of-desvenlafaxine-succinate-tablets
#5
Wael Samy, Ayman Elnoby, Hanan M El-Gowelli, Nazik Elgindy
Purpose: Desvenlafaxine succinate (DSV) is a water soluble anti-depressant drug, which is rapidly absorbed after oral administration exaggerating its side effects. The current work aimed to prepare controllable release DSV matrix to reduce DSV side effects related to its initial burst. Methods: Fifteen DSV matrix formulations were prepared using different polymers, polymer/drug ratios and matrix excipients and characterized using Differential Scanning Calorimetry (DSC), infrared (IR) spectroscopy, water uptake and in vitro DSV release...
July 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28724561/management-of-antithrombotic-agents-in-patients-undergoing-flexible-bronchoscopy
#6
REVIEW
Sami Abuqayyas, Shine Raju, John R Bartholomew, Roulan Abu Hweij, Atul C Mehta
Bleeding is one of the most feared complications of flexible bronchoscopy. Although infrequent, it can be catastrophic and result in fatal outcomes. Compared to other endoscopic procedures, the risk of morbidity and mortality from the bleeding is increased, as even a small amount of blood can fill the tracheobronchial tree and lead to respiratory failure. Patients using antithrombotic agents (ATAs) have higher bleeding risk. A thorough understanding of the different ATAs is critical to manage patients during the peri-procedural period...
September 30, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28722139/structure-based-release-analysis-of-the-jc-virus-agnoprotein-regions-a-role-for-the-hydrophilic-surface-of-the-major-alpha-helix-domain-in-release
#7
A Sami Saribas, Martyn K White, Mahmut Safak
Agnoprotein (Agno) is an important regulatory protein of JC virus (JCV), BK virus (BKV) and simian virus 40 (SV40) and these viruses are unable to replicate efficiently in the absence of this protein. Recent 3D-NMR structural data revealed that Agno contains two alpha-helices (a minor and a major) while the rest of the protein adopts an unstructured conformation (Coric et al., 2017, J Cell Biochem). Previously, release of the JCV Agno from the Agno-positive cells was reported. Here, we have further mapped the regions of Agno responsible for its release by a structure-based systematic mutagenesis approach...
July 19, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28719395/closing-the-gap-in-cochlear-implant-access-for-african-americans-a-story-of-outreach-and-collaboration-by-our-cochlear-implant-program
#8
Sheree Sims, Lisa Houston, Ivy Schweinzger, Ravi N Samy
PURPOSE OF REVIEW: Minorities often lag behind in hearing loss evaluation and treatment. Our cochlear implant program aimed to identify the socioeconomic and cultural barriers that prevented our African-American cochlear implant candidates from seeking help for their hearing loss, specifically cochlear implant surgery. RECENT FINDINGS: Our pilot study surveyed 11 African-Americans with cochlear implants and identified obstacles that included patient-physician mistrust, social stigma, financial cost, and lack of education about the devices and procedures...
July 14, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28719336/infant-nutritional-status-feeding-practices-enteropathogen-exposure-socioeconomic-status-and-illness-are-associated-with-gut-barrier-function-as-assessed-by-the-lactulose-mannitol-test-in-the-mal-ed-birth-cohort
#9
Gwenyth O Lee, Benjamin J J McCormick, Jessica C Seidman, Margaret N Kosek, Rashidul Haque, Maribel Paredes Olortegui, Aldo A M Lima, Zulfiqar A Bhutta, Gagandeep Kang, Amidou Samie, Caroline Amour, Carl J Mason, Tahmeed Ahmed, Pablo Peñataro Yori, Domingos B Oliveira, Didar Alam, Sudhir Babji, Pascal Bessong, Estomih Mduma, Sanjaya K Shrestha, Ramya Ambikapathi, Dennis R Lang, Michael Gottlieb, Richard L Guerrant, Laura E Caulfield, For The Mal-Ed Network Investigators
The lactulose mannitol (LM) dual sugar permeability test is the most commonly used test of environmental enteropathy in developing countries. However, there is a large but conflicting literature on its association with enteric infection and host nutritional status. We conducted a longitudinal cohort using a single field protocol and comparable laboratory procedures to examine intestinal permeability in multiple, geographically diverse pediatric populations. Using a previously published systematic review to guide the selection of factors potentially associated with LM test results, we examined the relationships between these factors and mucosal breach, represented by percent lactulose excretion; absorptive area, represented by percent mannitol excretion; and gut barrier function, represented by the L/M ratio...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28718080/a-comparison-of-live-birth-rates-and-perinatal-outcomes-between-cryopreserved-oocytes-and-cryopreserved-embryos
#10
Jacqueline R Ho, Irene Woo, Kristin Louie, Wael Salem, Sami I Jabara, Kristin A Bendikson, Richard J Paulson, Karine Chung
PURPOSE: Prior studies suggest that pregnancy outcomes after autologous oocyte cryopreservation are similar to fresh in vitro fertilization (IVF) cycles. It is unknown whether there are differences in pregnancy and perinatal outcomes between cryopreserved oocytes and cryopreserved embryos. METHODS: This is a retrospective cohort study comparing pregnancy and perinatal outcomes between oocyte and embryo cryopreservation at a university-based fertility center. We included 42 patients and 68 embryo transfers in patients who underwent embryo transfer after elective oocyte preservation (frozen oocyte-derived embryo transfer (FOET)) from 2005 to 2015...
July 17, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28717311/using-real-time-polymerase-chain-reaction-as-an-alternative-rapid-method-for-enumeration-of-colony-count-in-live-brucella-vaccines
#11
Waleed S Shell, Mahmoud L Sayed, A A Samy, Ghada Mohamed Al-Sadek, Gina Mohamed Mohamed Abd El-Hamid, Abdel Hakam M Ali
AIM: Brucellosis is a major bacterial zoonosis of global importance affecting a range of animal species and man worldwide. It has economic, public health, and bio-risk importance. Control and prevention of animal brucellosis mainly depend on accurate diagnostic tools and implementation of effective and safe animal vaccination program. There are three types of animal Brucella live vaccines - Brucella melitensis Rev-1 vaccine, Brucella abortus S19, and B. abortus RB51. Evaluation of these vaccines depends mainly on enumeration of Brucella viable count...
June 2017: Veterinary World
https://www.readbyqxmd.com/read/28716773/uncommon-cause-of-cervicobrachial-neuralgia-epidural-abscess-complicating-tuberculous-arthritis
#12
Sami Kouki, Manel Landolsi, Mehdi Ben Lassoued, Imen Gharsallah
No abstract text is available yet for this article.
July 17, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28716642/long-term-use-of-inhaled-corticosteroids-in-copd-and-the-risk-of-fracture
#13
Anne V Gonzalez, Janie Coulombe, Pierre Ernst, Samy Suissa
INTRODUCTION: It is uncertain whether long-term use of inhaled corticosteroids (ICS), widely used to treat COPD, increases the risk of fracture, particularly in women, in view of the post-menopausal risks. We assessed whether long-term ICS use in patients with COPD increases the risk of hip or upper extremity fractures, and examined sex-related differences. METHODS: The Quebec healthcare databases were used to form a cohort of patients with COPD over 1990-2005, followed until 2007 for the first hip or upper extremity fracture...
July 14, 2017: Chest
https://www.readbyqxmd.com/read/28711368/the-safety-and-feasibility-of-early-discharge-following-ileostomy-reversal-a-national-surgical-quality-improvement-program-analysis
#14
Arash Azin, Emily Le Souder, David Urbach, Allan Okrainec, Sami A Chadi, Fayez Quereshy, Timothy D Jackson, Ahmad Elnahas
BACKGROUND: This study aimed to compare 30-day clinical outcomes following routine ileostomy reversal between patients that underwent early discharge (<24 h) and standard discharge (postoperative day [POD] 2 or 3). METHODS: A retrospective cohort analysis was conducted between 2005 and 2014 using the American College of Surgeons National Surgical Quality Improvement Program data set. All patients undergoing ileostomy reversal who were discharged on POD 0 or 1 (early discharge group [EDG]) versus POD 2 or 3 (standard discharge group [SDG]) were identified...
July 12, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28710706/synchronous-and-metastatic-papillary-and-follicular-thyroid-carcinomas-with-unique-molecular-signatures
#15
Vincent Cracolici, Ibro Mujacic, Sabah Kadri, Mir Alikhan, Nifang Niu, Jeremy P Segal, Lauren E Rosen, David H Sarne, Adam Morgan, Samy Desouky, Nicole A Cipriani
Despite the relatively high prevalence of thyroid cancer, the occurrence of multiple synchronous, distinct subtypes of primary thyroid carcinoma is uncommon. The incidental finding of papillary thyroid microcarcinoma in a gland with a biologically relevant follicular or medullary carcinoma is more frequent than the synchronous occurrence of multiple clinically significant carcinomas. We report a case of synchronous papillary and follicular thyroid carcinomas metastatic to lymph node and bone, respectively. Next generation sequencing showed BRAF V600E mutation in the primary papillary carcinoma and NRAS Q61R mutation in the primary follicular carcinoma and bony metastasis...
July 14, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28708636/the-impact-of-hearing-loss-on-society-in-general-an-underappreciated-problem
#16
Ravi N Samy
No abstract text is available yet for this article.
July 13, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28708395/dynamic-nuclear-polarization-of-long-lived-nuclear-spin-states-in-methyl-groups
#17
Jean-Nicolas Dumez, Basile Vuichoud, Daniele Mammoli, Aurélien Bornet, Arthur C Pinon, Gabriele Stevanato, Benno Meier, Geoffrey Bodenhausen, Sami Jannin, Malcolm H Levitt
We have induced hyperpolarized long-lived states in compounds containing 13C-bearing methyl groups by dynamic nuclear polarization (DNP) at cryogenic temperatures, followed by dissolution with a warm solvent. The hyperpolarized methyl long-lived states give rise to enhanced antiphase 13C NMR signals in solution, which often persist for times much longer than the 13C and 1H spin-lattice relaxation times under the same conditions. The DNP-induced effects are similar to quantum-rotor-induced-polarization (QRIP), but are observed in a wider range of compounds, since they do not depend critically on the height of the rotational barrier...
July 14, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28706848/bipolar-bone-loss-of-the-shoulder-joint-due-to-recurrent-instability-use-of-fresh-osteochondral-distal-tibia-and-humeral-head-allografts
#18
Daniel B Haber, Anthony Sanchez, George Sanchez, Marcio B Ferrari, Sami Ferdousian, Matthew T Provencher
With increasing shoulder instability events, the likelihood of a bony lesion of the glenoid and/or humeral head rises. Although bone loss of either the glenoid or humeral head may result in recurrent instability, bipolar lesions have been shown, in particular, to result in a negative and additive effect on glenohumeral stability. In the case of a bipolar lesion comprising severe glenoid bone loss and an engaging, "off-track" Hill-Sachs lesion, the bony foundation of the glenohumeral joint is compromised and bony augmentation is necessary...
June 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28706802/medial-meniscus-posterior-root-tear-repair-using-a-2-simple-suture-pullout-technique
#19
Tarek Mohamed Samy, Wael A M Nassar, Zeiad Mohamed Zakaria, Ahmed Khaled Farrag Abdelaziz
Medial meniscus posterior root tear is one of the underestimated knee injuries in terms of incidence. Despite its grave sequelae, using simple but effective technique can maintain the native knee joint longevity. In the current note, a 2-simple-suture pullout technique was used to effectively reduce the meniscus posterior root to its anatomic position. The success of the technique depended on proper tool selection as well as tibial tunnel direction that allowed easier root suturing and better suture tensioning, without inducing any iatrogenic articular cartilage injury or meniscal tissue loss...
June 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28705199/the-m-phase-specific-hyperphosphorylation-of-staufen2-involved-the-cyclin-dependent-kinase-cdk1
#20
Rémy Beaujois, Elizabeth Ottoni, Xin Zhang, Christina Gagnon, Sami HSine, Stéphanie Mollet, Wildriss Viranaicken, Luc DesGroseillers
BACKGROUND: Staufen2 (STAU2) is an RNA-binding protein involved in the post-transcriptional regulation of gene expression. This protein was shown to be required for organ formation and cell differentiation. Although STAU2 functions have been reported in neuronal cells, its role in dividing cells remains deeply uncharacterized. Especially, its regulation during the cell cycle is completely unknown. RESULTS: In this study, we showed that STAU2 isoforms display a mitosis-specific slow migration pattern on SDS-gels in all tested transformed and untransformed cell lines...
July 14, 2017: BMC Cell Biology
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