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https://www.readbyqxmd.com/read/28815888/friction-and-wetting-transitions-of-magnetic-droplets-on-micropillared-superhydrophobic-surfaces
#1
Anas Al-Azawi, Mika Latikka, Ville Jokinen, Sami Franssila, Robin H A Ras
Reliable characterization of wetting properties is essential for the development and optimization of superhydrophobic surfaces. Here, the dynamics of superhydrophobicity is studied including droplet friction and wetting transitions by using droplet oscillations on micropillared surfaces. Analyzing droplet oscillations by high-speed camera makes it possible to obtain energy dissipation parameters such as contact angle hysteresis force and viscous damping coefficients, which indicate pinning and viscous losses, respectively...
August 16, 2017: Small
https://www.readbyqxmd.com/read/28814360/skin-rash-in-a-2-week-old-infant
#2
Marjan Nassiri, Sami L Bahna
We presented a case of a male infant with annular patchy rash on his torso since 2 weeks of age. This was initially diagnosed as tinea corporis but did not respond to oral antifungal treatment. Because of the appearance of the rash and a history of a certain disease in a maternal aunt, we suspected the most probable cause of the rash and the diagnosis was confirmed by laboratory testing. Furthermore, laboratory screening of the mother, who was asymptomatic, revealed that she was seropositive for the disease and was counseled on the importance of follow-up...
September 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28813122/morphological-alterations-in-the-jejunal-mucosa-of-aged-rats-and-the-possible-protective-role-of-green-tea
#3
Zeinab Abel-Rehim Hassan, Agata Zauszkiewicz-Pawlak, Shaimaa A Abdelrahman, Sami Algaidi, Maha Desouky, Sally M Shalaby
INTRODUCTION: Gastrointestinal disorders become more prevalent with ageing. This study is aimed to describe morphological changes that occur in the jejunal mucosa of male albino rats as a result of ageing and the protective effect of green tea supplements. MATERIAL AND METHODS: The experiment was performed on sixty rats: thirty young-adult (6-month old, body mass 200-220 g) and thirty old (24-month-old, body mass 220-260 g) animals. Each group was further divided into two subgroups (n = 15 each): control rats and green tea-treated rats that received 1...
August 16, 2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28812743/cross-realm-assessment-of-climate-change-impacts-on-species-abundance-trends
#4
Diana E Bowler, Christian Hof, Peter Haase, Ingrid Kröncke, Oliver Schweiger, Rita Adrian, Léon Baert, Hans-Günther Bauer, Theo Blick, Rob W Brooker, Wouter Dekoninck, Sami Domisch, Reiner Eckmann, Frederik Hendrickx, Thomas Hickler, Stefan Klotz, Alexandra Kraberg, Ingolf Kühn, Silvia Matesanz, Angelika Meschede, Hermann Neumann, Robert O'Hara, David J Russell, Anne F Sell, Moritz Sonnewald, Stefan Stoll, Andrea Sundermann, Oliver Tackenberg, Michael Türkay, Fernando Valladares, Kok van Herk, Roel van Klink, Rikjan Vermeulen, Karin Voigtländer, Rüdiger Wagner, Erik Welk, Martin Wiemers, Karen H Wiltshire, Katrin Böhning-Gaese
Climate change, land-use change, pollution and exploitation are among the main drivers of species' population trends; however, their relative importance is much debated. We used a unique collection of over 1,000 local population time series in 22 communities across terrestrial, freshwater and marine realms within central Europe to compare the impacts of long-term temperature change and other environmental drivers from 1980 onwards. To disentangle different drivers, we related species' population trends to species- and driver-specific attributes, such as temperature and habitat preference or pollution tolerance...
February 17, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28811809/peppered-and-rare-gastric-and-duodenal-pseudomelanosis-a-case-series
#5
Sami Samiullah, Hadi Bhurgri, Arooj Babar, Fatima Samad, Moaz M Choudhary, Michael Demyen
Upper Gastrointestinal (GI) pseudomelanosis is an uncommon entity characterized by endoscopic visualization of speckled dark mucosal pigmentation. While described in the rectum and colon, 'melanosis' or more aptly 'pseudomelanosis' is rare in the duodenum and exceedingly rare in the stomach. Five cases of pseudomelanosis were encountered at our department. Four females and one male were diagnosed, with a mean age of 70 years. All patients exhibited duodenal pseudomelanosis, with one demonstrating gastric antral pseudomelanosis as well...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28811325/ppar%C3%AE-ligand-induced-annexin-a1-expression-determines-chemotherapy-response-via-deubiquitination-of-death-domain-kinase-rip-in-triple-negative-breast-cancers
#6
Luxi Chen, Yi Yuan, Shreya Kar, Madhu M Kanchi, Suruchi Arora, Ji E Kim, Pei F Koh, Einas Yousef, Ramar P Samy, Muthu K Shanmugam, Tuan Z Tan, Sung W Shin, Frank Arfuso, Han M Shen, Henry Yang, Boon C Goh, Joo I Park, Louis Gaboury, Peter E Lobie, Gautam Sethi, Lina Hk Lim, Alan P Kumar
Metastatic breast cancer is still remain incurable so far, new specifically targeted and more effective therapies for triple negative breast cancer (TNBC) are required in the clinic. In this study, our clinical data has established that basal and claudin-low subtypes of breast cancer (TNBC types) express significantly higher levels of Annexin A1 (ANXA1) with poor survival outcomes. Using human cancer cell lines which model the TNBC subtype, we observed a strong positive correlation between expression of ANXA1 and Peroxisome Proliferator-Activated Receptor gamma (PPARγ)...
August 15, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28808585/spinal-cord-injury-during-the-second-trimester-of-pregnancy
#7
Ahmad Zaheer Qureshi, Sami Ullah, Anas Jehad AlSaleh, Rubina' Ullah
INTRODUCTION: Pregnancies in women with spinal cord injury (SCI) are at greater risk of morbidity and mortality. Although pregnancy after SCI is well elaborated in the literature, SCI occurring during pregnancy is rarely reported. Abrupt changes in the body physiology because of SCI and the resulting disability add a risk to maternal and fetal well-being. Not only is the burden of care increased but there is also a higher risk of developing pressure ulcers, urinary tract infections, autonomic instability, intrauterine growth retardation and venous thromboembolism...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28808340/kr%C3%A3-ppel-like-factor-6-is-a-transcriptional-activator-of-autophagy-in-acute-liver-injury
#8
Svenja Sydor, Paul Manka, Jan Best, Sami Jafoui, Jan-Peter Sowa, Miguel Eugenio Zoubek, Virginia Hernandez-Gea, Francisco Javier Cubero, Julia Kälsch, Diana Vetter, Maria Isabel Fiel, Yujin Hoshida, C Billie Bian, Leonard J Nelson, Han Moshage, Klaas Nico Faber, Andreas Paul, Hideo A Baba, Guido Gerken, Scott L Friedman, Ali Canbay, Lars P Bechmann
Krüppel-like factor 6 (KLF6) is a transcription factor and tumor suppressor. We previously identified KLF6 as mediator of hepatocyte glucose and lipid homeostasis. The loss or reduction of KLF6 is linked to the progression of hepatocellular carcinoma, but its contribution to liver regeneration and repair in acute liver injury are lacking so far. Here we explore the role of KLF6 in acute liver injury models in mice, and in patients with acute liver failure (ALF). KLF6 was induced in hepatocytes in ALF, and in both acetaminophen (APAP)- and carbon tetrachloride (CCl4)-treated mice...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28806062/exploring-strategies-for-labeling-viruses-with-gold-nanoclusters-through-non-equilibrium-molecular-dynamics-simulations
#9
Emmi Pohjolainen, Sami Malola, Gerrit Groenhof, Hannu Häkkinen
Bio-compatible gold nanoclusters can be utilized as contrast agents in virus imaging. The labeling of viruses can be achieved non-covalently but site-specifically by linking the cluster to the hydrophobic pocket of a virus via a lipid-like pocket factor. We have estimated the binding affinities of three different pocket factors of echovirus 1 (EV1) in molecular dynamics simulations combined with non-equilibrium free energy calculations. We have also studied the effects on binding affinities with a pocket factor linked to the Au102pMBA44 nanocluster in different protonation states...
August 14, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28803656/outcomes-of-transcatheter-versus-surgical-aortic-valve-implantation-for-aortic-stenosis-in-patients-with-hepatic-cirrhosis
#10
Fahad Alqahtani, Sami Aljohani, Anas Ghabra, Fares Alahdab, Akram Kawsara, David R Holmes, Mohamad Alkhouli
Current risk prediction tools for transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR) do not include variables associated with clinically significant hepatic disease. Accordingly, outcome data of TAVI or SAVR in patients with liver cirrhosis are limited. We sought to assess contemporary trends and outcomes of TAVI and SAVR in patients with liver cirrhosis using a national database. The Nationwide Inpatient Sample was used to identify patients with liver cirrhosis who underwent TAVI or SAVR between 2003 and 2014...
July 14, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28802173/fungicidal-activity-of-copper-sputtered-flexible-surfaces-under-dark-and-actinic-light-against-azole-resistant-candida-albicans-and-candida-glabrata
#11
Myriam K S Ballo, Sami Rtimi, John Kiwi, César Pulgarin, José M Entenza, Alain Bizzini
Candida spp. are able to survive on hospital surfaces and causes healthcare-associated infections (HCAIs). Since surface cleaning and disinfecting interventions are not totally effective to eliminate Candida spp., new approaches should be devised. Copper (Cu) has widely recognized antifungal activity and the use of Cu-sputtered surfaces has recently been proposed to curb the spread of HCAIs. Moreover, the activity of Cu under the action of actinic light remains underexplored. We investigated the antifungal activity of Cu-sputtered polyester surfaces (Cu-PES) against azole-resistant Candida albicans and Candida glabrata under dark and low intensity visible light irradiation (4...
July 29, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28801743/investigation-of-an-optimal-cell-lysis-method-for-the-study-of-the-zinc-metalloproteome-of-histoplasma-capsulatum
#12
Anna M Donnell, Stephanie Lewis, Sami Abraham, Kavitha Subramanian, Julio Landero Figueroa, George S Deepe, Anne P Vonderheide
This work sought to assess optimal extraction conditions in the study of the metalloproteome of the dimorphic fungus Histoplasma capsulatum. One of the body's responses to H. capsulatum infection is sequestration of zinc within host macrophage (MØ), as reported by Vignesh et al. (Immunity 39:697-710, 2013) and Vignesh et al. (PLOS Pathog 9:E1003815, 2013). Thus, metalloproteins containing zinc were of greatest interest as it plays a critical role in survival of the fungus. One challenge in metalloproteomics is the preservation of the native structure of proteins to retain non-covalently bound metals...
August 12, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28801575/limits-of-radiomic-based-entropy-as-a-surrogate-of-tumor-heterogeneity-roi-area-acquisition-protocol-and-tissue-site-exert-substantial-influence
#13
Laurent Dercle, Samy Ammari, Mathilde Bateson, Paul Blanc Durand, Eva Haspinger, Christophe Massard, Cyril Jaudet, Andrea Varga, Eric Deutsch, Jean-Charles Soria, Charles Ferté
Entropy is a promising quantitative imaging biomarker for characterizing cancer imaging phenotype. Entropy has been associated with tumor gene expression, tumor metabolism, tumor stage, patient prognosis, and treatment response. Our hypothesis states that tumor-specific biomarkers such as entropy should be correlated between synchronous metastases. Therefore, a significant proportion of the variance of entropy should be attributed to the malignant process. We analyzed 112 patients with matched/paired synchronous metastases (SM#1 and SM#2) prospectively enrolled in the MOSCATO-01 clinical trial...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28798256/metabolic-characterization-and-rna-profiling-reveal-glycolytic-dependence-of-pro-fibrotic-phenotype-of-alveolar-macrophages-in-lung-fibrosis
#14
Na Xie, Huachun Cui, Jing Ge, Sami Banerjee, Sijia Guo, Shubham Dubey, Edward Abraham, Rui-Ming Liu, Gang Liu
Metabolic reprogramming has been intrinsically linked to macrophage activation. Alveolar macrophages are known to play an important role in the pathogenesis of pulmonary fibrosis. However, systematic characterization of expression profile in these cells is still lacking. Furthermore, main metabolic programs and their regulation of cellular phenotype are completely unknown. In this study, we comprehensively analyzed the expression profile and main metabolic programs in alveolar macrophages from mice with or without experimental pulmonary fibrosis...
August 10, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28797665/functionalized-polymer-monoliths-with-carbamylated-amylose-for-the-enantioselective-reversed-phase-nano-liquid-chromatographic-separation-of-a-set-of-racemic-pharmaceuticals
#15
Ali Fouad, Adel A Marzouk, Samy M Ibrahim, Sobhy M El-Adl, Ashraf Ghanem
Here we report the first encapsulation of three carbamylated amylose namely R-, S- and R/S-amylose 2,3(3,5-dimethylphenylcarbamate)-6-ethylphenylcarbamate in organic polymer monolith in situ capillary columns. The columns were investigated for the enantioselective nano-liquid chromatographic separation of a set of racemic pharmaceuticals, namely, α- and β-blockers, anti-inflammatory drugs, antifungal drugs, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, antihistaminics, anticancer drugs, and antiarrhythmic drugs...
July 23, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28797382/precision-medicine-urgency-the-case-of-inhaled-corticosteroids-in-copd
#16
EDITORIAL
Samy Suissa, Pierre Ernst
No abstract text is available yet for this article.
August 2017: Chest
https://www.readbyqxmd.com/read/28795037/unusual-presentation-of-a-penetrating-aortic-arch-injury
#17
Fikret Sami Vural, Atul Kumar Patel, Kashif Mustafa
A 27-year-old man was admitted with a penetrating injury at the mid-manubrium. Computed tomographic (CT) angiography showed a filling defect in the aortic arch. This was evaluated as a sign of injury and the patient underwent an emergency operation. No active bleeding or clot was found in the mediastinum during the operation. The laceration point was between the innominate and the left carotid artery posteriorly. The injury was approached using hypothermic circulatory arrest. Aortotomy and exploration showed a 2-cm-long full-thickness aortic injury with an overlying clot...
August 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28791578/protective-role-of-antioxidants-capacity-of-hyrtios-aff-erectus-sponge-extract-against-mixture-of-persistent-organic-pollutants-pops-induced-hepatic-toxicity-in-mice-liver-biomarkers-and-ultrastructural-study
#18
Nehad M Abd El-Moneam, Mohamed A Shreadah, Samy A El-Assar, Asmaa Nabil-Adam
The current study investigates the hepatoprotective effect of Hyrtios aff. Erectus sponge extract against POPs intoxication on endogenous antioxidant enzymes and lipid peroxidation in mice liver tissue. In the present study, the mice BALB/C were assigned into four groups: group I: received saline subcutaneously for 7 days and served as negative control; group II: received subcutaneously for 7 days, 130.6 mg/100 g/b. w/day POPs mixture(mixture of PCB 28, PCB 52,, PCB 101, PCB 118, PCB 153, PCB 138 and PCB 180, alpha-Hexachlorocyclohexane, beta-Hexachloro-cyclohexane, gamma-hexachlorocyclohexane, Aldrin, O,P'-DDE, Dieldrin, P,p DDE, O,P DDD, Endrin, P,p DDD and P,pDDT were extracted from sediments collected from Lake Mariout), and served as induced group; group III: pretreated with Hyrtios aff...
August 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28790449/single-cell-analyses-identify-bioengineered-niches-for-enhanced-maintenance-of-hematopoietic-stem-cells
#19
Aline Roch, Sonja Giger, Mukul Girotra, Vasco Campos, Nicola Vannini, Olaia Naveiras, Samy Gobaa, Matthias P Lutolf
The in vitro expansion of long-term hematopoietic stem cells (HSCs) remains a substantial challenge, largely because of our limited understanding of the mechanisms that control HSC fate choices. Using single-cell multigene expression analysis and time-lapse microscopy, here we define gene expression signatures and cell cycle hallmarks of murine HSCs and the earliest multipotent progenitors (MPPs), and analyze systematically single HSC fate choices in culture. Our analysis revealed twelve differentially expressed genes marking the quiescent HSC state, including four genes encoding cell-cell interaction signals in the niche...
August 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28783427/molecular-epidemiology-of-carbapenem-resistant-acinetobacter-baumannii-in-a-tertiary-care-hospital-in-egypt-clonal-spread-of-blaoxa-23
#20
Afaf Mohamed Samy El Bannah, Nada Nabil Nawar, Reem Mostafa Mohamed Hassan, Sherifa Tarek Bassiouni Salem
Of great concern is the increased frequency of carbapenem-resistant Acinetobacter baumannii (CRAB) causing healthcare-associated infections. Different classes of β-lactamases are involved in this resistance through hydrolyzing carbapenems. Multilocus sequence typing (MLST) has been applied successfully for characterizing different varieties of bacterial pathogens epidemiologically. In the present study, we aimed to type and characterize the resistance profile of clinical isolates of CRAB causing healthcare-associated infections in patients admitted to Kasr Al-Aini hospital, using MLST, and compare with sequence types (STs) from other countries...
August 7, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
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