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https://www.readbyqxmd.com/read/28645722/circulating-bone-related-markers-and-ykl-40-versus-her2-and-topo2a-in-bone-metastatic-and-nonmetastatic-breast-cancer-diagnostic-implications
#1
Olfat Gamil Shaker, Hebatullah Samy Helmy
BACKGROUND: The bone represents one of the most common sites of metastases in breast cancer. The aim of the current study was to evaluate the diagnostic potential of several circulating markers to detect metastasis to bones in patients with breast cancer. PATIENTS AND METHODS: Receptor activator of Nuclear Factor-kappa β (NF-Kβ) ligand (RANKL), osteoprotegrin (OPG), vitamin D (VIT D), Chitinase-3-like protein 1; also known as YKL-40, topoisomerase IIα (TOPO2a), and human epidermal growth factor receptor 2 (HER2) were measured in blood samples obtained from 122 patients with breast cancer and 25 healthy controls...
June 7, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28644347/age-and-sex-normalization-of-intestinal-permeability-measures-for-the-improved-assessment-of-enteropathy-in-infancy-and-early-childhood-results-from-the-mal-ed-study
#2
Margaret N Kosek, Gwenyth O Lee, Richard L Guerrant, Rashidul Haque, Gagandeep Kang, Tahmeed Ahmed, Pascal Bessong, Asad Ali, Estomih Mduma, Pablo Peñataro Yori, William A Faubion, Aldo A M Lima, Maribel Paredes Olortegui, Carl Mason, Sudhir Babji, Ravinder Singh, Shahida Qureshi, Peter S Kosek, Amidou Samie, John Pascal, Sanjaya Shrestha, Benjamin J J McCormick, Jessica C Seidman, Dennis R Lang, Anita Zaidi, Laura E Caulfield, Michael Gottlieb
OBJECTIVES: The aim of the study was to describe changes in intestinal permeability in early childhood in diverse epidemiologic settings. METHODS: In a birth cohort study, the lactulose:mannitol (L:M) test was administered to 1980 children at 4 time points in the first 24 months of life in 8 countries. Data from the Brazil site with an incidence of diarrhea similar to that seen in the United States and no growth faltering was used as an internal study reference to derive age- and sex-specific z scores for mannitol and lactulose recoveries and the L:M ratio...
July 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28644201/insular-epilepsy-semiology-and-noninvasive-investigations
#3
Sami Obaid, Younes Zerouali, Dang Khoa Nguyen
In this review, authors discuss the semiology and noninvasive investigations of insular epilepsy, an underrecognized type of epilepsy, which may mimic other focal epilepsies. In line with the various functions of the insula and its widespread network of connections, insular epilepsy may feature a variety of early ictal manifestations from somatosensory, visceral, olfactory, gustatory, or vestibular manifestations. Depending on propagation pathways, insular seizures may also include altered consciousness, dystonic posturing, complex motor behaviors, and even autonomic features...
July 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28642311/run-in-bias-in-randomised-trials-the-case-of-copd-medications
#4
EDITORIAL
Samy Suissa
No abstract text is available yet for this article.
June 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28642056/can-stem-cells-ameliorate-the-pancreatic-damage-induced-by-streptozotocin-in-rats
#5
Amira Ragab El Barky, Amany Abdel Hamid Ezz, Abeer Abd-Elhameed Alm-Eldeen, Samy Ali Hussein, Yehia Ahmed Hafez, Tarek Mostafa Mohamed
BACKGROUND: Stem cell therapy holds great promise for the repair of injured tissues and organs, and it is one of the most promising therapies for diabetes mellitus. Therefore, the present study was undertaken to elucidate the antidiabetic effect of both mesenchymal stem cells (MSCs) and insulin-producing cells (IPCs) on streptozotocin (STZ)-induced diabetes in rats. MATERIALS AND METHODS: MSCs were derived from bone marrow of male albino rats. MSCs were characterized morphologically and by Cluster of differentiation (CD(-ve34)) and (CD(+ve105))...
June 19, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28641846/conduction-abnormalities-and-permanent%C3%A2-pacemaker-implantation-after-transcatheter-aortic-valve-replacement-using-the-repositionable-lotus-device-the-united-kingdom-experience
#6
Rajiv Rampat, M Zeeshan Khawaja, Roland Hilling-Smith, Jonathan Byrne, Philip MacCarthy, Daniel J Blackman, Arvindra Krishnamurthy, Ashan Gunarathne, Jan Kovac, Adrian Banning, Raj Kharbanda, Sami Firoozi, Stephen Brecker, Simon Redwood, Vinayak Bapat, Michael Mullen, Suneil Aggarwal, Ganesh Manoharan, Mark S Spence, Saib Khogali, Maureen Dooley, James Cockburn, Adam de Belder, Uday Trivedi, David Hildick-Smith
OBJECTIVES: The authors report the incidence of pacemaker implantation up to hospital discharge and the factors influencing pacing rate following implantation of the LOTUS bioprosthesis (Boston Scientific, Natick, Massachusetts) in the United Kingdom. BACKGROUND: Transcatheter aortic valve replacement (TAVR) is associated with a significant need for permanent pacemaker implantation. Pacing rates vary according to the device used. The REPRISE II (Repositionable Percutaneous Replacement of Stenotic Aortic Valve Through Implantation of Lotus Valve System) trial reported a pacing rate of 29% at 30 days after implantation of the LOTUS device...
June 26, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28639264/magnetic-resonance-spin-spin-relaxation-time-estimation-in-a-rat-model-of-fatty-liver-disease
#7
Sami Alghamdi, Benjamin Sinclair, Gary Cowin, Ian Brereton, Yasvir A Tesiram
PURPOSE: To compare mono- and bi-exponential relaxation model equations to discriminate between normal and fatty liver disease. MATERIALS AND METHODS: Six rats on a choline deficient amino acid modified (CDAA) diet and six on normal chow were studied. Multiple spin echo images with increasing echo times (TEs) were collected at 9.4T. Pixel-wise T2 maps were generated using mono-exponential decay function to calculate T2M , and a bi-exponential to calculate, short T2 component (T2S ), long T2 component (T2L ), and fractions of these components (ρS , ρL ), respectively...
June 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28639149/safety-feasibility-results-and-economic-impact-of-common-interventional-procedures-in-a-low-volume-region-of-the-united-states
#8
Aaron Clem, Sami Awadallah, Zahid Amin
The aim of the study was to evaluate the safety, feasibility, and economic benefit of a high-volume operator performing common interventional procedures in a rural region of the United States (U.S.). Rural areas of the U.S., even with well-equipped cardiac catheterization laboratories, may not have a full-time pediatric interventional cardiologist (PIC); this requires patients to travel out of state even for simple interventions. Since 2005, we have adopted a policy of performing cardiac catheterizations and common interventional procedures with a visiting PIC...
June 21, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28638745/obesity-cardiovascular-disease-and-sleep-disorders-insights-into-the-rising-epidemic
#9
Navneet Sharma, Justin Lee, Irini Youssef, Moro O Salifu, Samy I McFarlane
Cardiovascular disease (CVD) is the main cause of death among adult men and women in the USA and impacts millions around the globe. Traditional risk factors for CVD include obesity, diabetes, hypertension and dyslipidemia. The modern-day epidemic of obesity not only increased the rate of CVD but also ushered in an additional CVD risk factor to be added to the list; that is obstructive sleep apnea (OSA). In this review, we discuss the growing epidemic of obesity and OSA, highlighting the common pathogenic hypotheses linking these risk factors to CVD...
March 2017: Journal of Sleep Disorders & Therapy
https://www.readbyqxmd.com/read/28638735/maternal-microchimerism-is-prevalent-in-cord-blood-in-memory-t-cells-and-other-cell-subsets-and-persists-post-transplant
#10
Sami B Kanaan, Hilary S Gammill, Whitney E Harrington, Stephen C De Rosa, Philip A Stevenson, Alexandra M Forsyth, Judy Allen, Emma Cousin, Koen van Besien, Colleen S Delaney, J Lee Nelson
Among reported advantages of umbilical cord blood (CB) in transplantation is lower leukemia relapse probability. Underlying cellular mechanisms of graft-vs.-leukemia (GVL) are thought to include a prominent role for T cells. Cells of the CB's mother, maternal microchimerism (MMc), were recently strongly, but indirectly, implicated in this GVL benefit. We assayed MMc directly and hypothesized benefit accrues from CB maternal T cells. MMc was quantified in 51 CBs and, within memory T, naïve T, B, NK cells, and monocytes in 27 CBs...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28637546/impact-of-preinjury-anticoagulation-with-warfarin-on-outcomes-of-adult-trauma-patients-experience-of-a-level-1-trauma-center
#11
Sami Hossri, Sassine Ghanem, Samer Saouma, Krassimir Atanassov
No abstract text is available yet for this article.
June 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28633652/spontaneous-rupture-of-the-common-hepatic-duct-associated-with-acute-pancreatitis-a-case-report
#12
Makram Moussa, Wissem Triki, Omar Karray, Ines Marzouk, Bouchoucha Sami
BACKGROUND: Rupture of the common bile duct is a life-threatening condition, usually observed after a trauma or in association with choledocholithiasis or an obstructive tumor of the bile duct. However, a spontaneous rupture of the common bile duct is a rare entity. CASE PRESENTATION: We report a new observation of a spontaneous rupture of the common bile duct, associated with biliary peritonitis and pancreatitis, in a 15-year-old North African girl. Etiological aspects, specificities of clinical presentation, means of diagnosis, as well as surgical and perioperative management are discussed...
June 21, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28631482/carbohydrate-bis-acetal-based-substrates-as-tunable-fluorescence-quenched-probes-for-monitoring-exo-glycosidase-activity
#13
Samy Cecioni, David J Vocadlo
Tunable Förster resonance energy transfer (FRET)-quenched substrates are useful for monitoring the activity of various enzymes within their relevant physiological environments. Development of FRET-quenched substrates for exo-glycosidases, however, has been hindered by their constrained pocket-shaped active sites. Here we report the design of a new class of substrate that overcomes this problem. These Bis-Acetal-Based Substrates (BABS) bear a hemiacetal aglycon leaving group that tethers fluorochromes in close proximity, also positioning them distant from the active site pocket...
June 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28630686/fecal-carriage-of-extended-spectrum-%C3%AE-lactamase-and-carbapenemase-producing-enterobacteriaceae-in-egyptian-patients-with-community-onset-gastrointestinal-complaints-a-hospital-based-cross-sectional-study
#14
H M Abdallah, N Alnaiemi, E A Reuland, B B Wintermans, A Koek, A M Abdelwahab, A Samy, K W Abdelsalam, C M J E Vandenbroucke-Grauls
OBJECTIVES: The aim of this study was to determine the prevalence of extended-spectrum β-lactamase (ESBL) and carbapenemase production among Enterobacteriaceae isolated from ambulatory patients with gastrointestinal complaints admitted to El-Ahrar General Hospital, Zagazig, Egypt in the period between January 2013 and May 2013. METHODS: One hundred and thirteen Enterobacteriaceae isolates were recovered from 100 consecutive Egyptian patients with community-onset gastrointestinal complaints...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28630225/lipoma-of-right-pyriform-sinus
#15
Muhammad Sami Jabbr, Iyad Hamadi, Mouhannad Mahmoud Abdulber Fakoury, Gamal Yousef Youssef
We present a case of large mass arising from the right pyriform sinus extending inferiorly to the postcricoid area and superiorly to the right aryepiglottic fold causing a foreign body sensation and obstructive symptoms, its histological examination following the endoscopic surgical excision showed a lipoma. We are also describing the endoscopic, radiological and intraoperative findings with a brief literature review.
June 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28627455/gemcitabine-vitamin-e-conjugates-synthesis-characterization-entrapment-into-nanoemulsions-and-in-vitro-deamination-and-antitumor-activity
#16
Ahmed Abu-Fayyad, Sami Nazzal
Gemcitabine is the first line therapy for pancreatic cancer. It is, however, extensively metabolized to the inactive form by deamination enzymatic reaction. Conjugation of gemcitabine with fatty acids on its 4-amino group was found to protect it from deamination deactivation reaction. The objective of the present study was to test the in-vitro anticancer activity of gemcitabine conjugated to the γ-tocotrienol isomer of vitamin E against pancreatic tumor cells. This objective was based on reported studies in which it was demonstrated that free tocotrienol isomers of vitamin E can potentiate the anticancer activity of gemcitabine...
June 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28627454/synthesis-physiochemical-characterization-and-in-vitro-antitumor-activity-of-the-amide-and-ph-cleavable-hydrazone-conjugates-of-%C3%AE-tocotrienol-isomer-of-vitamin-e-with-methoxy-poly-ethylene-glycol
#17
Ahmed Abu-Fayyad, Sami Nazzal
The anticancer activity of water soluble methoxy polyethylene glycol (mPEG) derivatives of tocotrienol (T3) isomers of vitamin E was previously found to be reduced when compared to the parent free isomers. This could be due to the ester bond formation between the mPEG and the 6-OH group on the chroman moiety of the T3 isomer. To further investigate, the objectives of the current study were to (1) synthesize and characterize stable amide and cleavable hydrazone conjugates between mPEG and carbon-5 on the chroman moiety of T3, and (2) examine the cytotoxicity of the newly synthesized mPEG conjugates against breast (MCF-7 and MDA-MB-231) and pancreatic (BxPC-3 and PANC-1) cancer cells...
June 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28627263/association-of-interleukin-1a-insertion-deletion-gene-polymorphism-and-possible-high-risk-factors-with-non-alcoholic-fatty-liver-disease-in-egyptian-patients
#18
Asmaa R Abdel-Hamed, Maivel H Ghattas, Noha M Mesbah, Samy M Saleh, Dina M Abo-Elmatty
CONTEXT: Interleukin-1A (IL-1A) is a cytokine involved in inflammatory process. IL-1A (rs3783553) gene polymorphism is comprised in the regulation of IL-1A expression. OBJECTIVE: This study aims to evaluate association of IL-1A (I/D) gene polymorphism with NAFLD and its component traits among Egyptian populations. METHODS: The study included 75 healthy subjects and 75 patients with NAFLD. Different genotypes of IL-1A (I/D) gene polymorphism were determined by PCR-PAGE technique, serum IL-1A level and other biochemical parameters were measured...
June 18, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28626749/a-century-spent-combating-rabies-in-morocco-1911-2015-how-much-longer
#19
Sami Darkaoui, Florence Cliquet, Marine Wasniewski, Emmanuelle Robardet, Nadia Aboulfidaa, Mohammed Bouslikhane, Ouafaa Fassi-Fihri
Rabies has no known beginning in Morocco and to date, government control efforts and plans fail to eradicate the disease. A review and analysis of available epidemiological data are crucial to learn lessons from the past and to propose effective actions. Legally, animal rabies is a notifiable disease since 1913 and legislation has been updated periodically since. Dogs have always been considered as both the disease's vector and reservoir, while cattle, other herbivores, and humans are victims. Animal rabies cases evolution from 1942 to 2015 is characterized by ascending phase then decreasing one following structured rabies control plan implementation in 1980s...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28626581/carcinosarcoma-of-the-maxillary-sinus-a-rare-case-report
#20
Jawad Hasnaoui, Said Anajar, Mohammed Tatari, Reda Abada, Sami Rouadi, Mohammed Roubal, Mohammed Mahtar
INTRODUCTION: Carcinosarcoma is a highly malignant tumor characterized by dual malignant histologic differentiation of epithelial and mesenchymal components. The tumor is extremely rare in the sinonasal tract, with only 13 cases reported since 1957 in the literature. PRESENTATION OF CASE: We report a case of a 55-year-old man with right-sided face pain revealed a mass in the right maxillary sinus and nasal cavity. A large incisional biopsy from the nasal cavity concluded the diagnosis of carcinosarcoma...
July 2017: Annals of Medicine and Surgery
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