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https://www.readbyqxmd.com/read/28299396/no-correlation-between-mthfr-c-677-c%C3%A2-%C3%A2-t-mthfr-c-1298-a%C3%A2-%C3%A2-c-and-abcb1-c-3435-c%C3%A2-%C3%A2-t-polymorphisms-and-methotrexate-therapeutic-outcome-of-rheumatoid-arthritis-in-west-algerian-population
#1
Wefa Boughrara, Ahmed Benzaoui, Meriem Aberkane, Fatima Zohra Moghtit, Samia Dorgham, Aicha Sarah Lardjam-Hetraf, Hadjer Ouhaibi-Djellouli, Elisabeth Petit Teixeira, Abdallah Boudjema
CONTEXT: The c.677 C > T and c.1298 A > C polymorphisms of methylenetatrahydrofolate reductase (MTHFR) gene and c.3435 C > T polymorphism of ATP-Binding cassette B1 (ABCB1) gene are reported as pharmacogenetic markers, influencing the methotrexate (MTX) therapeutic outcome in rheumatoid arthritis (RA) patients. OBJECTIVES: The aims of this study were to determine the relationship between these polymorphisms and clinical response and/or adverse drug reaction (ADRs) to MTX treatment...
March 15, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28295690/azole-resistance-in-candida-albicans-from-animals-highlights-on-efflux-pump-activity-and-gene-overexpression
#2
Marcos Fábio Gadelha Rocha, Silviane Praciano Bandeira, Lucas Pereira de Alencar, Luciana Magalhães Melo, Jamille Alencar Sales, Manoel de Araújo Neto Paiva, Carlos Eduardo Cordeiro Teixeira, Débora de Souza Collares Maia Castelo-Branco, Waldemiro de Aquino Pereira-Neto, Rossana de Aguiar Cordeiro, José Júlio Costa Sidrim, Raimunda Sâmia Nogueira Brilhante
This study investigated potential mechanisms of azole resistance among Candida albicans from animals, including efflux pump activity, ergosterol content and gene expression. For this purpose, 30 azole-resistant C. albicans strains from animals were tested for their antifungal susceptibility, according to document M27-A3, efflux pump activity by rhodamine 6G test, ergosterol content and expression of the genes CDR1, CDR2, MDR1, ERG11 by RT-qPCR. These strains were resistant to at least one azole derivative...
March 10, 2017: Mycoses
https://www.readbyqxmd.com/read/28157763/effect-of-procedural-related-variables-on-melanocyte-keratinocyte-suspension-transplantation-in-nonsegmental-stable-vitiligo-a-clinical-and-immunocytochemical-study
#3
Bakr Mohamed El-Zawahry, Samia Esmat, Dalia Bassiouny, Naglaa Sameh Zaki, Rehab Sobhi, Marwah A Saleh, Dalia Abdel-Halim, Rehab Hegazy, Heba Gawdat, Nesrin Samir, Marwa El-Hawary, Zeinab El Maadawi, Heba Gouda, Mervat Khorshied
BACKGROUND: Melanocyte-keratinocyte suspension (M-K susp) is gaining popularity for vitiligo treatment. Few studies have addressed procedure-related variables. OBJECTIVE: To assess the effect of different M-K susp procedure-related variables on the clinical outcome in stable vitiligo. METHODS: This prospective multicenter comparative study included 40 cases with nonsegmental stable vitiligo. Donor site was either a skin graft in noncultured epidermal cell suspension (NCECS) or hair follicle units in outer root sheath hair follicle suspension (ORSHFS)...
February 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28125638/vaca-and-caga-status-as-biomarker-of-two-opposite-end-outcomes-of-helicobacter-pylori-infection-gastric-cancer-and-duodenal-ulcer-in-a-moroccan-population
#4
Mounia El Khadir, Samia Alaoui Boukhris, Dafr-Allah Benajah, Karima El Rhazi, Sidi Adil Ibrahimi, Mohamed El Abkari, Taoufiq Harmouch, Chakib Nejjari, Mustapha Mahmoud, Mohamed Benlemlih, Bahia Bennani
Helicobacter pylori (H. pylori) infection induces inflammation of the gastric mucosa, which may progress to precancerous lesions leading to gastric cancer. Pathological determinism is associated to some virulence genes of the bacterium, notably the vacA and cagA genes. The present study aimed to determine the H. pylori genotypes distribution and their association with sex, age and gastric diseases in a Moroccan population. Gastric biopsy was taken from 1079 consenting patients. The specimens were processed by PCR to identify H...
2017: PloS One
https://www.readbyqxmd.com/read/27994418/a-retrospective-cross-sectional-study-on-the-prevalence-of-hypodontia-in-a-target-population-of-al-jouf-province-saudi-arabia
#5
Arbaz Sajjad, Samia Subhani Sajjad, Nadeem Husain, Ahmed Maashi Al-Enezi
AIM: The purpose of this retrospective study was to determine the prevalence of hypodontia and to ascertain the need of interdisciplinary treatment for ensuing esthetic and functional problems in a target population of Al-Jouf Province, Saudi Arabia. SUBJECTS AND METHODS: Using a dental administration software tool, a total of 1267 patients who presented to the outpatient clinics of the Orthodontic and Prosthodontic Departments between March 2015 and January 2016 were identified...
October 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/27725884/agroindustrial-wastes-as-alternative-for-lipase-production-by-candida-viswanathii-under-solid-state-cultivation-purification-biochemical-properties-and-its-potential-for-poultry-fat-hydrolysis
#6
Alex Fernando de Almeida, Kleydiane Braga Dias, Ana Carolina Cerri da Silva, César Rafael Fanchini Terrasan, Sâmia Maria Tauk-Tornisielo, Eleonora Cano Carmona
The aims of this work were to establish improved conditions for lipase production by Candida viswanathii using agroindustrial wastes in solid-state cultivation and to purify and evaluate the application of this enzyme for poultry fat hydrolysis. Mixed wheat bran plus spent barley grain (1 : 1, w/w) supplemented with 25.0% (w/w) olive oil increased the lipase production to 322.4%, compared to the initial conditions. When olive oil was replaced by poultry fat, the highest lipase production found at 40% (w/w) was 31...
2016: Enzyme Research
https://www.readbyqxmd.com/read/27710986/the-epidemiology-of-pituitary-adenomas-in-a-community-based-hospital-a-retrospective-single-center-study-in-saudi-arabia
#7
Khalid S Aljabri, Samia A Bokhari, Faisal Y Assiri, Muneera A Alshareef, Patan M Khan
BACKGROUND: Data on pituitary adenoma (PA) prevalence in Saudi Arabia are scarce. OBJECTIVE: To estimate the epidemiology of PA in a well-defined population. DESIGN: Retrospective analysis. SETTING: Departments of Endocrinology and Radiology at King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia. PATIENTS AND METHODS: Radiological and hormonal data of patients with pituitary adenoma by MRI were reviewed for the period January 2008 to December 2015...
September 2016: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/27649085/white-matter-lesions-prevalence-and-clinical-phenotype-in-asymptomatic-individuals-aged-%C3%A2-50-years
#8
Jean-Philippe David, Emilie Ferrat, Juliette Parisot, Henri Naga, Samia Lakroun, Feriel Menasria, Sofiane Saddedine, Pierre-André Natella, Elena Paillaud, Isabelle Fromentin, Sylvie Bastuji-Garin
BACKGROUND: To assess the prevalence of early confluent/confluent white matter lesions (ec/cWMLs) in asymptomatic individuals aged ≥50 years and to identify associated clinical phenotypes. METHODS: Cross-sectional analysis of 141 asymptomatic individuals aged ≥50 years assessed at an outpatient department in France. Brain magnetic resonance imaging was rated using the Fazekas scale. Age-adjusted odds ratios (ORs) and 95% confidence intervals were estimated using logistic models to investigate factors associated with ec/cWMLs; independent risk factors were identified by multivariate analysis...
2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27642453/-valvular-calcifications-in-a-patient-on-hemodialysis-in-morocco
#9
Samia Ait Faqih, Béfa Noto-Kadou-Kaza, Lalla Meryam Abouamrane, Naoufal Mtiou, Selma El Khaya, Mohamed Zamd, Ghislaine Medkouri, Mohamed Gharbi Bengahanem, Benyounes Ramdani
INTRODUCTION: Valvular calcifications are one of the major cardiovascular complications of hemodialysis because of its prevalence and its predictive indices of morbidity and mortality. There are many risk factors associated with these calcifications. Our study aims to evaluate both the prevalence of valvular calcifications in our patients on hemodialysis and their risk factors. METHODS: This was a single-center cross-sectional descriptive and analytical study of 111 adult patients who were on hemodialysis for more than 6 months at the hemodialysis center CHU Ibn Rushd, Casablanca and who underwent ETT during the year 2013...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27520529/terpinen-4-ol-tyrosol-and-%C3%AE-lapachone-as-potential-antifungals-against-dimorphic-fungi
#10
Raimunda Sâmia Nogueira Brilhante, Érica Pacheco Caetano, Rita Amanda Chaves de Lima, Francisca Jakelyne de Farias Marques, Débora de Souza Collares Maia Castelo-Branco, Charlline Vládia Silva de Melo, Glaucia Morgana de Melo Guedes, Jonathas Sales de Oliveira, Zoilo Pires de Camargo, José Luciano Bezerra Moreira, André Jalles Monteiro, Tereza de Jesus Pinheiro Gomes Bandeira, Rossana de Aguiar Cordeiro, Marcos Fábio Gadelha Rocha, José Júlio Costa Sidrim
This study aimed to evaluate the in vitro antifungal activity of terpinen-4-ol, tyrosol, and β-lapachone against strains of Coccidioides posadasii in filamentous phase (n=22) and Histoplasma capsulatum in both filamentous (n=40) and yeast phases (n=13), using the broth dilution methods as described by the Clinical and Laboratory Standards Institute, to determine the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of these compounds. The mechanisms of action of these compounds were also investigated by analyzing their effect on cell membrane permeability and ergosterol synthesis...
October 2016: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/27506747/physical-exercise-alleviates-er-stress-in-obese-humans-through-reduction-in-the-expression-and-release-of-grp78-chaperone
#11
Abdelkrim Khadir, Sina Kavalakatt, Jehad Abubaker, Preethi Cherian, Dhanya Madhu, Irina Al-Khairi, Mohamed Abu-Farha, Samia Warsame, Naser Elkum, Mohammed Dehbi, Ali Tiss
BACKGROUND AND OBJECTIVES: Perturbation of the endoplasmic reticulum (ER) homeostasis has emerged as one of the prominent features of obesity and diabetes. This occurs when the adaptive unfolded protein response (UPR) fails to restore ER function in key metabolic tissues. We previously reported increased inflammation and impaired heat shock response (HSR) in obese human subjects that were restored by physical exercise. Here, we investigated the status of ER stress chaperone; glucose-regulated protein 78 (GRP78) and its downstream UPR pathways in human obese, and their modulation by a supervised 3-month physical exercise...
September 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27235445/fasting-is-not-routinely-required-for-determination-of-a-lipid-profile-clinical-and-laboratory-implications-including-flagging-at-desirable-concentration-cutpoints-a-joint-consensus-statement-from-the-european-atherosclerosis-society-and-european-federation
#12
Børge G Nordestgaard, Anne Langsted, Samia Mora, Genovefa Kolovou, Hannsjörg Baum, Eric Bruckert, Gerald F Watts, Grazyna Sypniewska, Olov Wiklund, Jan Borén, M John Chapman, Christa Cobbaert, Olivier S Descamps, Arnold von Eckardstein, Pia R Kamstrup, Kari Pulkki, Florian Kronenberg, Alan T Remaley, Nader Rifai, Emilio Ros, Michel Langlois
AIMS: To critically evaluate the clinical implications of the use of non-fasting rather than fasting lipid profiles and to provide guidance for the laboratory reporting of abnormal non-fasting or fasting lipid profiles. METHODS AND RESULTS: Extensive observational data, in which random non-fasting lipid profiles have been compared with those determined under fasting conditions, indicate that the maximal mean changes at 1-6 h after habitual meals are not clinically significant [+0...
July 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27146922/estimation-of-the-prevalence-of-inadequate-and-excessive-iodine-intakes-in-school-age-children-from-the-adjusted-distribution-of-urinary-iodine-concentrations-from-population-surveys
#13
Michael B Zimmermann, Izzeldin Hussein, Samia Al Ghannami, Salah El Badawi, Nawal M Al Hamad, Basima Abbas Hajj, Mohamed Al-Thani, Al Anoud Al-Thani, Pattanee Winichagoon, Tippawan Pongcharoen, Frits van der Haar, Jia Qing-Zhen, Susanne Dold, Maria Andersson, Alicia L Carriquiry
BACKGROUND: The urinary iodine concentration (UIC), a biomarker of iodine intake, is used to assess population iodine status by deriving the median UIC, but this does not quantify the percentage of individuals with habitually deficient or excess iodine intakes. Individuals with a UIC <100 μg/L or ≥300 μg/L are often incorrectly classified as having deficient or excess intakes, but this likely overestimates the true prevalence. OBJECTIVE: Our aim was to estimate the prevalence of inadequate and excess iodine intake in children (aged 4-14 y) with the distribution of spot UIC from iodine surveys...
June 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27122601/fasting-is-not-routinely-required-for-determination-of-a-lipid-profile-clinical-and-laboratory-implications-including-flagging-at-desirable-concentration-cut-points-a-joint-consensus-statement-from-the-european-atherosclerosis-society-and-european-federation
#14
REVIEW
Børge G Nordestgaard, Anne Langsted, Samia Mora, Genovefa Kolovou, Hannsjörg Baum, Eric Bruckert, Gerald F Watts, Grazyna Sypniewska, Olov Wiklund, Jan Borén, M John Chapman, Christa Cobbaert, Olivier S Descamps, Arnold von Eckardstein, Pia R Kamstrup, Kari Pulkki, Florian Kronenberg, Alan T Remaley, Nader Rifai, Emilio Ros, Michel Langlois
AIMS: To critically evaluate the clinical implications of the use of non-fasting rather than fasting lipid profiles and to provide guidance for the laboratory reporting of abnormal non-fasting or fasting lipid profiles. METHODS AND RESULTS: Extensive observational data, in which random non-fasting lipid profiles have been compared with those determined under fasting conditions, indicate that the maximal mean changes at 1-6 h after habitual meals are not clinically significant [+0...
July 1, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27041857/essential-oil-from-the-resin-of-protium-heptaphyllum-chemical-composition-cytotoxicity-antimicrobial-activity-and-antimutagenicity
#15
Ewelyne Miranda de Lima, Didley Sâmia Paiva Cazelli, Fernanda Endringer Pinto, Renata Alves Mazuco, Ieda Carneiro Kalil, Dominik Lenz, Rodrigo Scherer, Tadeu Uggere de Andrade, Denise Coutinho Endringer
BACKGROUND: Protium heptaphyllum (Aubl.) March is popularly used as an analgesic and anti-inflammatory agent. OBJECTIVE: This study aimed to evaluate the chemical composition of P. heptaphyllum essential oil, its cytotoxicity in a breast cancer cell line (MCF-7), antimicrobial activity, and its antimutagenicity in vivo. MATERIALS AND METHODS: The chemical composition of the essential oil collected in three 3 years was determined by gas chromatography-mass spectrometry...
January 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27038950/a-strain-of-meyerozyma-guilliermondii-isolated-from-sugarcane-juice-is-able-to-grow-and-ferment-pentoses-in-synthetic-and-bagasse-hydrolysate-media
#16
Cristina Martini, Sâmia Maria Tauk-Tornisielo, Carolina Brito Codato, Reinaldo Gaspar Bastos, Sandra Regina Ceccato-Antonini
The search for new microbial strains that are able to withstand inhibitors released from hemicellulosic hydrolysis and are also still able to convert sugars in ethanol/xylitol is highly desirable. A yeast strain isolated from sugarcane juice and identified as Meyerozyma guilliermondii was evaluated for the ability to grow and ferment pentoses in synthetic media and in sugarcane bagasse hydrolysate. The yeast grew in xylose, arabinose and glucose at the same rate at an initial medium pH of 5.5. At pH 4.5, the yeast grew more slowly in arabinose...
May 2016: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27030250/carglumic-acid-enhances-rapid-ammonia-detoxification-in-classical-organic-acidurias-with-a-favourable-risk-benefit-profile-a-retrospective-observational-study
#17
MULTICENTER STUDY
Vassili Valayannopoulos, Julien Baruteau, Maria Bueno Delgado, Aline Cano, Maria L Couce, Mireia Del Toro, Maria Alice Donati, Angeles Garcia-Cazorla, David Gil-Ortega, Pedro Gomez-de Quero, Nathalie Guffon, Floris C Hofstede, Sema Kalkan-Ucar, Mahmut Coker, Rosa Lama-More, Mercedes Martinez-Pardo Casanova, Agustin Molina, Samia Pichard, Francesco Papadia, Patricia Rosello, Celine Plisson, Jeannie Le Mouhaer, Anupam Chakrapani
BACKGROUND: Isovaleric aciduria (IVA), propionic aciduria (PA) and methylmalonic aciduria (MMA) are inherited organic acidurias (OAs) in which impaired organic acid metabolism induces hyperammonaemia arising partly from secondary deficiency of N-acetylglutamate (NAG) synthase. Rapid reduction in plasma ammonia is required to prevent neurological complications. This retrospective, multicentre, open-label, uncontrolled, phase IIIb study evaluated the efficacy and safety of carglumic acid, a synthetic structural analogue of NAG, for treating hyperammonaemia during OA decompensation...
March 31, 2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27029728/-the-link-between-trace-elements-and-metabolic-syndrome-oxidative-stress-in-essential-hypertension-with-or-without-type-2-diabetes
#18
Ines Gouaref, Zina Bellahsene, Samia Zekri, Barkahoum Alamir, Elhadj-Ahmed Koceir
The relationship between trace elements (TE) and essential hypertension (EH) is subtle and complex. This relationship is mediated by endothelial dysfunction, insulin resistance, oxidative stress (OS) and athero-inflammatory state. The aim of this study was to examine the TE impact; particularly selenium (Se), zinc (Zn), copper (Cu) and manganese (Mn) as predictive type 2 diabetes biomarkers in a hypertensive subject. The study was undertaken on 400 adult patients (40-60 years), who were divided in 4 groups: hypertensive (H), type 2 diabetes (T2D), hypertensive-diabetic (HD) and healthy group...
March 2016: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/26951635/circulating-n-linked-glycoprotein-acetyls-and-longitudinal-mortality-risk
#19
COMPARATIVE STUDY
Patrick R Lawler, Akintunde O Akinkuolie, Paulette D Chandler, M Vinayaga Moorthy, Martin J Vandenburgh, Debra A Schaumberg, I-Min Lee, Robert J Glynn, Paul M Ridker, Julie E Buring, Samia Mora
RATIONALE: Circulating glycoprotein N-acetyl glucosamine residues have recently been associated with incident cardiovascular disease and diabetes mellitus. OBJECTIVE: Using a plasma glycan biosignature (GlycA) to identify circulating N-acetyl glycan groups, we examined the longitudinal association between GlycA and mortality among initially healthy individuals. METHODS AND RESULTS: We quantified GlycA by 400 MHz (1)H nuclear magnetic resonance spectroscopy in 27,524 participants in the Women's Health Study (NCT00000479)...
April 1, 2016: Circulation Research
https://www.readbyqxmd.com/read/26844231/prevalence-of-urinary-tract-infection-and-antimicrobial-susceptibility-among-diabetic-patients-with-controlled-and-uncontrolled-glycemia-in-kuwait
#20
May Sewify, Shinu Nair, Samia Warsame, Mohamed Murad, Asma Alhubail, Kazem Behbehani, Faisal Al-Refaei, Ali Tiss
Diabetic patients have higher risk of urinary tract infection (UTI). In the present study, we investigated the impact of glycemic control in diabetic patients on UTI prevalence, type of strains, and their antimicrobial drugs susceptibility. This study was conducted on urine samples from 722 adult diabetic patients from which 252 (35%) samples were positive for uropathogens. Most UTI cases occurred in the uncontrolled glycemic group (197 patients) versus 55 patients with controlled glycemia. Higher glycemic levels were measured in uncontrolled glycemia group (HbA1c = 8...
2016: Journal of Diabetes Research
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