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https://www.readbyqxmd.com/read/29753282/efficient-hptlc-dual-wavelength-spectrodensitometric-method-for-simultaneous-determination-of-sofosbuvir-and-daclatasvir-biological-and-pharmaceutical-analysis
#1
Mohammad Nabil Abo-Zeid, Samia M El-Gizawy, Noha N Atia, Salwa R El-Shaboury
Sofosbuvir (SOF) and daclatasvir (DCS) are newly discovered anti-hepatitis C drugs that have direct antiviral activity. A novel and simple high-performance thin-layer chromatography (HPTLC) method was designed for simultaneous determination of SOF and DCS in miscellaneous matrices. The method adopts coupling HPTLC with dual wavelength spectrodensitometry. Consequently, this enabled sensitive, specific and cost-effective determination of the SOF-DCS mixture. The developed HPTLC procedure is based on a simple liquid-liquid extraction, enrichment of the analytes and subsequent chromatographic separation with UV detection...
May 1, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29678788/response-surface-methodology-for-production-characterization-and-application-of-solvent-salt-and-alkali-tolerant-alkaline-protease-from-isolated-fungal-strain-aspergillus-niger-wa-2017
#2
Walaa A Abdel Wahab, Samia A Ahmed
Isolated strain Aspergillus niger WA 2017 was selected as potential protease producer and was identified on the basis of 18S rDNA gene homology. Optimization of protease production conditions was performed using statistical methodology. The most significant factors were identified by Plackett-Burman design (PB) and were optimized by central composite design (CCD). The enzyme production was increased by 3.6-fold with statistically optimized medium when compared to the basal medium. Based on the protease activity, 25-50% ethanol fraction exhibited the highest specific activity...
April 17, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29625886/evaluation-of-staff-radiation-exposure-during-transthoracic-echocardiography-close-to-myocardial-perfusion-imaging
#3
Samia Massalha, Rachel Lugassi, Elyahu Raysberg, Amjad Koskosi, Gerson Lechtenberg, Ora Israel, John A Kennedy
BACKGROUND: Transthoracic echocardiography (TTE) and myocardial perfusion imaging (MPI) are used in cardiac patients. In this study the radiation exposure of sonographers performing TTE following MPI was evaluated. METHODS: Of 40 study patients, 30 underwent same-day 99m Tc sestamibi MPI and TTE, while another 10 underwent only TTE. Patients who underwent both studies were divided into three groups: right-handed TTE performed by an echocardiographer and right- and left-handed TTE performed by a cardiac sonographer...
April 3, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29523885/cost-effectiveness-analysis-of-haploidentical-vs-matched-unrelated-allogeneic-hematopoietic-stem-cells-transplantation-in-patients-older-than-55-years
#4
Mathias Debals-Gonthier, Carole Siani, Catherine Faucher, Rajae Touzani, Claude Lemarié-Basset, Christian Chabannon, Sabine Furst, Raynier Devillier, Samia Harbi, Luca Castagna, Laurence Caymaris, Didier Blaise, Anne-Gaëlle Le Corroller Soriano
Due to limited donor availability, high comorbidities, and cost issues, allogeneic hematopoietic stem cell transplant is not universally accessible. The aim of this study was to conduct a cost-effectiveness analysis of haploidentical vs matched unrelated transplant. This retrospective study included patients with hematological malignancies older than 55 years who underwent haploidentical or matched unrelated transplant between 2011 and 2013 in Marseille. The incremental cost-effectiveness ratio has been calculated using the mean overall survival and the mean transplant costs...
March 9, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29408004/enhancement-stability-and-catalytic-activity-of-immobilized-%C3%AE-amylase-using-bioactive-phospho-silicate-glass-as-a-novel-inorganic-support
#5
Samia A Ahmed, Faten A Mostafa, Mona A Ouis
α-Amylase enzyme was immobilized on bioactive phospho-silicate glass (PS-glass) as a novel inorganic support by physical adsorption and covalent binding methods using glutaraldehyde and poly glutaraldehyde as a spacer. Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) studies confirmed the glass-enzyme linkage. Dissolution of PS-glass in acidic and neutral pH is higher than that of alkaline pH. Some immobilization variables were optimized using statistical factorial design (Central Composite Design)...
June 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29121898/clinicopathologic-and-prognostic-features-of-breast-cancer-in-young-women-a-series-from-north-of-morocco
#6
Joaira Bakkach, Mohamed Mansouri, Touria Derkaoui, Ali Loudiyi, Mohamed Fihri, Samia Hassani, Amina Barakat, Naima Ghailani Nourouti, Mohcine Bennani Mechita
BACKGROUND: Literature data reported a higher frequency of breast cancer in young women (BCYW) in developing countries. BCYW is associated with delayed diagnosis, aggressive biology and poor prognosis. However, our knowledge of biological profile, treatment received and outcome of young patients is still limited in Morocco. We propose to analyze clinicopathologic, therapeutic and prognostic features of BCYW among a series of patients native and/or inhabitant of North of Morocco. METHODS: We carried out a retro-prospective study of 331 infiltrating breast cancer cases registered between January 2010 and December 2015...
November 9, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29097515/adiposity-and-genetic-factors-in-relation-to-triglycerides-and-triglyceride-rich-lipoproteins-in-the-women-s-genome-health-study
#7
Shafqat Ahmad, Samia Mora, Paul W Franks, Marju Orho-Melander, Paul M Ridker, Frank B Hu, Daniel I Chasman
BACKGROUND: Previous results from Scandinavian cohorts have shown that obesity accentuates the effects of common genetic susceptibility variants on increased triglycerides (TG). Whether such interactions are present in the US population and further selective for particular TG-rich lipoprotein subfractions is unknown. METHODS: We examined these questions using body mass index (BMI) and waist circumference (WC) among women of European ancestry from the Women's Genome Health Study (WGHS) (n = 21840 for BMI; n = 19313 for WC)...
January 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/28969710/molecular-detection-of-leishmania-infantum-and-leishmania-tropica-in-rodent-species-from-endemic-cutaneous-leishmaniasis-areas-in-morocco
#8
Mohamed Echchakery, Carmen Chicharro, Samia Boussaa, Javier Nieto, Eugenia Carrillo, Ortega Sheila, Javier Moreno, Ali Boumezzough
BACKGROUND: Leishmaniasis remains a major public health problem in African nations, including Morocco, where little is known about the vertebrate reservoirs involved in the causal parasites' transmission cycles. The present study investigates the role of rodent species as potential reservoirs of Leishmania spp. in central Morocco, where both L. tropica and L. infantum have been reported. METHODS: Rodents were caught from 22 sites in central Morocco, by using Sherman metal traps, and identified morphologically...
October 2, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28893746/demographic-profile-and-pregnancy-outcomes-of-adolescents-and-older-mothers-in-saudi-arabia-analysis-from-riyadh-mother-rahma-and-baby-cohort-study
#9
Amel A Fayed, Hayfaa Wahabi, Heba Mamdouh, Reham Kotb, Samia Esmaeil
OBJECTIVES: To investigate the impact of maternal age on pregnancy outcomes with special emphasis on adolescents and older mothers and to investigate the differences in demographic profile between adolescents and older mothers. METHODS: This study is a secondary analysis of pregnancy outcomes of women in Riyadh Mother and Baby cohort study according to maternal age. The study population was grouped according to maternal age into five subgroups; <20, 20-29, 30-34, 35-39 and 40+years...
September 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28892181/the-impact-of-obesity-and-timely-antiviral-administration-on-severe-influenza-outcomes-among-hospitalized-adults
#10
Hannah E Segaloff, Richard Evans, Samia Arshad, Marcus J Zervos, Carolyn Archer, Keith S Kaye, Emily T Martin
Obesity was identified as a risk factor for severe influenza during the 2009 influenza A(H1N1)pandemic, but evidence of this association has been mixed since. Post-pandemic antiviral treatment guidelines may have increased antiviral treatment among obese individuals. A prospective study of adults hospitalized with laboratory-confirmed influenza in Detroit, Michigan in 2011-2012 and 2012-2013 was conducted. Patient information was collected from interviews and medical chart abstraction. Obese (BMI ≥ 30) and non-obese (BMI < 30) participants were compared...
February 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/28783898/innovative-spe-lc-ms-ms-technique-for-the-assessment-of-63-pharmaceuticals-and-the-detection-of-antibiotic-resistant-bacteria-a-case-study-natural-water-sources-in-lebanon
#11
Samia Mokh, Mohammad El Khatib, Mohamad Koubar, Zeina Daher, Mohamad Al Iskandarani
A powerful analytical method for simultaneous determination of 63 pharmaceuticals and some metabolites in aqueous samples has been developed. The list of compounds amenable to the methods includes different therapeutic classes belonging to antibiotics, stimulants, antidepressants, mucolytics, and antiparasites. The method involves concentration and clean up by an offline solid phase extraction SPE followed by liquid chromatography coupled to tandem mass spectrometry (LC-ESI-MS/MS). The recovery of the target compounds from water samples was most efficient on Waters Oasis HLB SPE cartridge, while acetonitrile/water (60/40) was shown to be the most suitable solvent for desorbing the compounds from SPE...
December 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28759053/the-eukaryotic-gut-virome-in-hematopoietic-stem-cell-transplantation-new-clues-in-enteric-graft-versus-host-disease
#12
Jérôme Legoff, Matthieu Resche-Rigon, Jerome Bouquet, Marie Robin, Samia N Naccache, Séverine Mercier-Delarue, Scot Federman, Erik Samayoa, Clotilde Rousseau, Prescillia Piron, Nathalie Kapel, François Simon, Gérard Socié, Charles Y Chiu
Much attention has been focused on the role of the bacterial microbiome in human health, but the virome is understudied. Although previously investigated in individuals with inflammatory bowel diseases or solid-organ transplants, virome dynamics in allogeneic hematopoietic stem cell transplantation (HSCT) and enteric graft-versus-host disease (GVHD) remain unexplored. Here we characterize the longitudinal gut virome in 44 recipients of HSCT using metagenomics. A viral 'bloom' was identified, and significant increases were demonstrated in the overall proportion of vertebrate viral sequences following transplantation (P = 0...
September 2017: Nature Medicine
https://www.readbyqxmd.com/read/28692456/focal-necrotizing-myopathy-with-dropped-head-syndrome-induced-by-cobimetinib-in-metastatic-melanoma
#13
Marie-Léa Gauci, Pauline Laly, Sarah Leonard-Louis, Anthony Behin, Jérémy Gottlieb, Isabelle Madelaine-Chambrin, Barouyr Baroudjian, Laetitia Da-Meda, Samia Mourah, Maxime Battistella, Nicole Basset-Seguin, Martine Bagot, Cécile Pages, Laetitia Vercellino, Thierry Maisonobe, Céleste Lebbé
Therapeutic advances derived from targeted therapy and immune checkpoint inhibitors can improve melanoma prognosis. Since 2015, cobimetinib has been approved in combination with vemurafenib in the first-line treatment for BRAF-mutated melanoma. For NRAS-mutated melanomas, MEK inhibition seems to be a therapeutic target, and association with checkpoint inhibitor provides a further therapeutic perspective. Infraclinical creatine phosphokinase (CPK) elevation is an MEK inhibitor side effect. We describe a case of focal necrotizing myopathy with 'dropped-head syndrome' induced by cobimetinib, 1 month after its introduction...
October 2017: Melanoma Research
https://www.readbyqxmd.com/read/28386562/prevalence-and-complications-of-pregestational-and-gestational-diabetes-in-saudi-women-analysis-from-riyadh-mother-and-baby-cohort-study-rahma
#14
Hayfaa Wahabi, Amel Fayed, Samia Esmaeil, Heba Mamdouh, Reham Kotb
The objectives of this study were to estimate the burden of diabetes and to explore the adverse pregnancy outcomes associated with pregestational diabetes mellitus (pre-GDM) and gestational diabetes mellitus (GDM) among the Saudi pregnant population. In this subcohort, we compared the maternal and the neonatal outcomes of diabetic women with pre-GDM and GDM to the outcomes of nondiabetic mothers who delivered during the same period. From the total cohort, 9723 women participated in this study. Of the participants, 24...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28299396/no-correlation-between-mthfr-c-677-c-t-mthfr-c-1298-a-c-and-abcb1-c-3435-c-t-polymorphisms-and-methotrexate-therapeutic-outcome-of-rheumatoid-arthritis-in-west-algerian-population
#15
Wefa Boughrara, Ahmed Benzaoui, Meriem Aberkane, Fatima Zohra Moghtit, Samia Dorgham, Aicha Sarah Lardjam-Hetraf, Hadjer Ouhaibi-Djellouli, Elisabeth Petit Teixeira, Abdallah Boudjema
CONTEXT: The c.677 C > T and c.1298 A > C polymorphisms of methylenetatrahydrofolate reductase (MTHFR) gene and c.3435 C > T polymorphism of ATP-Binding cassette B1 (ABCB1) gene are reported as pharmacogenetic markers, influencing the methotrexate (MTX) therapeutic outcome in rheumatoid arthritis (RA) patients. OBJECTIVES: The aims of this study were to determine the relationship between these polymorphisms and clinical response and/or adverse drug reaction (ADRs) to MTX treatment...
June 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28295690/azole-resistance-in-candida-albicans-from-animals-highlights-on-efflux-pump-activity-and-gene-overexpression
#16
Marcos Fábio Gadelha Rocha, Silviane Praciano Bandeira, Lucas Pereira de Alencar, Luciana Magalhães Melo, Jamille Alencar Sales, Manoel de Araújo Neto Paiva, Carlos Eduardo Cordeiro Teixeira, Débora de Souza Collares Maia Castelo-Branco, Waldemiro de Aquino Pereira-Neto, Rossana de Aguiar Cordeiro, José Júlio Costa Sidrim, Raimunda Sâmia Nogueira Brilhante
This study investigated potential mechanisms of azole resistance among Candida albicans from animals, including efflux pump activity, ergosterol content and gene expression. For this purpose, 30 azole-resistant C. albicans strains from animals were tested for their antifungal susceptibility, according to document M27-A3, efflux pump activity by rhodamine 6G test, ergosterol content and expression of the genes CDR1, CDR2, MDR1, ERG11 by RT-qPCR. These strains were resistant to at least one azole derivative...
July 2017: Mycoses
https://www.readbyqxmd.com/read/28157763/effect-of-procedural-related-variables-on-melanocyte-keratinocyte-suspension-transplantation-in-nonsegmental-stable-vitiligo-a-clinical-and-immunocytochemical-study
#17
MULTICENTER STUDY
Bakr Mohamed El-Zawahry, Samia Esmat, Dalia Bassiouny, Naglaa Sameh Zaki, Rehab Sobhi, Marwah A Saleh, Dalia Abdel-Halim, Rehab Hegazy, Heba Gawdat, Nesrin Samir, Marwa El-Hawary, Zeinab El Maadawi, Heba Gouda, Mervat Khorshied
BACKGROUND: Melanocyte-keratinocyte suspension (M-K susp) is gaining popularity for vitiligo treatment. Few studies have addressed procedure-related variables. OBJECTIVE: To assess the effect of different M-K susp procedure-related variables on the clinical outcome in stable vitiligo. METHODS: This prospective multicenter comparative study included 40 cases with nonsegmental stable vitiligo. Donor site was either a skin graft in noncultured epidermal cell suspension (NCECS) or hair follicle units in outer root sheath hair follicle suspension (ORSHFS)...
February 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28125638/vaca-and-caga-status-as-biomarker-of-two-opposite-end-outcomes-of-helicobacter-pylori-infection-gastric-cancer-and-duodenal-ulcer-in-a-moroccan-population
#18
Mounia El Khadir, Samia Alaoui Boukhris, Dafr-Allah Benajah, Karima El Rhazi, Sidi Adil Ibrahimi, Mohamed El Abkari, Taoufiq Harmouch, Chakib Nejjari, Mustapha Mahmoud, Mohamed Benlemlih, Bahia Bennani
Helicobacter pylori (H. pylori) infection induces inflammation of the gastric mucosa, which may progress to precancerous lesions leading to gastric cancer. Pathological determinism is associated to some virulence genes of the bacterium, notably the vacA and cagA genes. The present study aimed to determine the H. pylori genotypes distribution and their association with sex, age and gastric diseases in a Moroccan population. Gastric biopsy was taken from 1079 consenting patients. The specimens were processed by PCR to identify H...
2017: PloS One
https://www.readbyqxmd.com/read/27994418/a-retrospective-cross-sectional-study-on-the-prevalence-of-hypodontia-in-a-target-population-of-al-jouf-province-saudi-arabia
#19
Arbaz Sajjad, Samia Subhani Sajjad, Nadeem Husain, Ahmed Maashi Al-Enezi
AIM: The purpose of this retrospective study was to determine the prevalence of hypodontia and to ascertain the need of interdisciplinary treatment for ensuing esthetic and functional problems in a target population of Al-Jouf Province, Saudi Arabia. SUBJECTS AND METHODS: Using a dental administration software tool, a total of 1267 patients who presented to the outpatient clinics of the Orthodontic and Prosthodontic Departments between March 2015 and January 2016 were identified...
October 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/27725884/agroindustrial-wastes-as-alternative-for-lipase-production-by-candida-viswanathii-under-solid-state-cultivation-purification-biochemical-properties-and-its-potential-for-poultry-fat-hydrolysis
#20
Alex Fernando de Almeida, Kleydiane Braga Dias, Ana Carolina Cerri da Silva, César Rafael Fanchini Terrasan, Sâmia Maria Tauk-Tornisielo, Eleonora Cano Carmona
The aims of this work were to establish improved conditions for lipase production by Candida viswanathii using agroindustrial wastes in solid-state cultivation and to purify and evaluate the application of this enzyme for poultry fat hydrolysis. Mixed wheat bran plus spent barley grain (1 : 1, w/w) supplemented with 25.0% (w/w) olive oil increased the lipase production to 322.4%, compared to the initial conditions. When olive oil was replaced by poultry fat, the highest lipase production found at 40% (w/w) was 31...
2016: Enzyme Research
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