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https://www.readbyqxmd.com/read/28729757/protein-protein-interfaces-are-vdw-dominant-with-selective-h-bonds-and-or-electrostatics-towards-broad-functional-specificity
#1
Christina Nilofer, Anshul Sukhwal, Arumugam Mohanapriya, Pandjassarame Kangueane
Several catalysis, cellular regulation, immune function, cell wall assembly, transport, signaling and inhibition occur through Protein- Protein Interactions (PPI). This is possible with the formation of specific yet stable protein-protein interfaces. Therefore, it is of interest to understand its molecular principles using structural data in relation to known function. Several interface features have been documented using known X-ray structures of protein complexes since 1975. This has improved our understanding of the interface using structural features such as interface area, binding energy, hydrophobicity, relative hydrophobicity, salt bridges and hydrogen bonds...
2017: Bioinformation
https://www.readbyqxmd.com/read/28727617/granulosa-cell-tumors-novel-predictors-of-recurrence-in-early-stage-patients
#2
Sharif Sakr, Eman Abdulfatah, Sumi Thomas, Zaid Al-Wahab, Rafic Beydoun, Robert Morris, Rouba Ali-Fehmi, Sudeshna Bandyopadhyay
Granulosa cell tumors (GCTs) comprise 2% to 5% of ovarian neoplasms, with unpredictable patterns of recurrence. The HER family, GATA4, and SMAD3 genes are reportedly involved in GCT proliferation and apoptosis and may serve as new predictors of recurrence. The aim of the study was to evaluate novel predictors of recurrence in GCT from a large single institution cohort. Patients diagnosed with GCTs (n=125) between 1975 and 2014 were identified. Clinicopathologic parameters were obtained and immunohistochemical evaluation was performed of calretinin, inhibin, HER2, CD56, SMAD3, and GATA4...
May 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28726462/allan-urho-paivio-1925-2016
#3
Albert Katz
Presents an obituary for Allan Urho Paivio, who passed away on June 19, 2016. One of his many accomplishments was the development of a dual-coding theory. Dual-coding theory, while very influential, has, unfortunately, been discussed all too often as a theory of mental imagery, and not within its larger context wherein mental imagery and verbal processes are separable but interconnected representational systems, an academic battle in clarification that Paivio waged much of his life. He published prodigiously, even in the decades after retirement...
July 2017: American Psychologist
https://www.readbyqxmd.com/read/28724844/a-review-of-the-active-treatments-for-toxic-epidermal-necrolysis
#4
Yuri Kinoshita, Hidehisa Saeki
Toxic epidermal necrolysis (TEN) is a severe adverse drug reaction associated with the separation of skin and mucous membranes at the dermal-epidermal junction. Although it is rare, many treatments have been trialed because of its high mortality rate. Active interventions performed to date include the use of systemic corticosteroids, intravenous immunoglobulins (IVIg), cyclosporine, plasmapheresis, anti-tumor necrosis factor drugs and N-acetylcysteine, but none has been established as the most effective therapy...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/28724142/the-aging-physician-and-the-medical-profession-a-review
#5
E Patchen Dellinger, Carlos A Pellegrini, Thomas H Gallagher
Importance: The issue of the aging physician and when to cease practice has been controversial for many years. There are reports of prominent physicians who practiced after becoming dangerous in old age, but the profession has not demonstrated the ability to prevent this. A mandatory retirement age could be discriminatory and take many competent physicians out of practice and risk a physician shortage. An increasing body of evidence regarding the relationship between physicians' age and performance has led organizations, such as the American College of Surgeons, to revisit this challenge...
July 19, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28724112/desert-vegetation-forty-years-after-an-oil-spill
#6
Mara Nothers, Nitzan Segev, Juergen Kreyling, Amgad Hjazin, Elli Groner
Deserts are the most frequent locations of terrestrial crude oil contaminations. Nevertheless, the long-term effects of petroleum hydrocarbons on desert ecosystems are still unknown, which makes risk assessment and decision making concerning remediation difficult. This study examined the long-term effects of petroleum hydrocarbons on perennial desert vegetation. The study site was a hyper-arid area in the south of Israel, which was contaminated by a crude oil spill in 1975. The contaminated area was compared to uncontaminated reference areas...
May 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28720108/early-pregnancy-sex-steroids-during-primiparous-pregnancies-and-maternal-breast-cancer-a-nested-case-control-study-in-the-northern-sweden-maternity-cohort
#7
Renée T Fortner, Eglé Tolockiene, Helena Schock, Husam Oda, Hans-Åke Lakso, Göran Hallmans, Rudolf Kaaks, Paolo Toniolo, Anne Zeleniuch-Jacquotte, Kjell Grankvist, Eva Lundin
BACKGROUND: Pregnancy and parity are associated with subsequent breast cancer risk. Experimental and epidemiologic data suggest a role for pregnancy sex steroid hormones. METHODS: We conducted a nested case-control study in the Northern Sweden Maternity Cohort (1975-2007). Eligible women had provided a blood sample in the first 20 weeks of gestation during a primiparous pregnancy leading to a term delivery. The current study includes 223 cases and 417 matched controls (matching factors: age at and date of blood collection)...
July 18, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28720022/good-work-ability-among-unemployed-individuals-association-of-sociodemographic-work-related-and-well-being-factors
#8
Marja Hult, Anna-Maija Pietilä, Päivikki Koponen, Terhi Saaranen
AIMS: The aims of this study were to describe the perceived work ability of unemployed individuals and to explore the association between perceived good work ability and sociodemographic, work-related and well-being factors. METHODS: The data were derived from the Finnish Regional Health and Well-being Study (ATH) collected by postal and Internet-based questionnaires in 2014-2015. The random sample was selected from the Finnish National Population Register. The present study includes data from unemployed or laid-off respondents ( n=1975) aged 20-65 years...
July 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28709661/left-sided-reoperations-after-arterial-switch-operation-a-european-multicenter-study
#9
Vladimiro L Vida, Lorenza Zanotto, Lucia Zanotto, Giovanni Stellin, Massimo Padalino, Georges Sarris, Eleftherios Protopapas, Carol Prospero, Christian Pizarro, Edward Woodford, Thomas Tlaskal, Hakan Berggren, Martin Kostolny, Ikenna Omeje, Boulos Asfour, Alexander Kadner, Thierry Carrel, Paul H Schoof, Matej Nosal, Josè Fragata, Michał Kozłowski, Bohdan Maruszewski, Luca A Vricella, Duke E Cameron, Vladimir Sojak, Mark Hazekamp, Jukka Salminen, Ilkka P Mattila, Julie Cleuziou, Patrick O Myers, Viktor Hraska
BACKGROUND: We sought to report the frequency, types, and outcomes of left-sided reoperations (LSRs) after an arterial switch operation (ASO) for patients with D-transposition of the great arteries (D-TGA) and double-outlet right ventricle (DORV) TGA-type. METHODS: Seventeen centers belonging to the European Congenital Heart Surgeons Association (ECHSA) contributed to data collection. We included 111 patients who underwent LSRs after 7,951 ASOs (1.4%) between January 1975 and December 2010...
July 11, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28709457/tubulointerstitial-nephritis-and-uveitis-tinu-syndrome-a-systematic-review-of-its-epidemiology-demographics-and-risk-factors
#10
REVIEW
Linda O Okafor, Peter Hewins, Philip I Murray, Alastair K Denniston
Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare oculorenal inflammatory condition that was first described in 1975. In 2001 a major review identified 133 cases in the world literature and proposed key diagnostic criteria for the condition. Although acknowledged as rare, the limited data available prevented reliable estimates of the prevalence of the condition, and hampered elucidation of the relationship between genetic and environmental factors that contribute to its pathogenesis.In this review we have performed a systematic search on the epidemiology, demographics and proposed risk factors for TINU...
July 14, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28708752/prevalence-of-burnout-in-health-professionals-working-in-palliative-care-a-systematic-review
#11
Vitor Parola, Adriana Coelho, Daniela Cardoso, Anna Sandgren, João Apóstolo
BACKGROUND: More than ever, the current increasing need for palliative care leads to health professionals providing this type of care which further leads to multiple challenges, and stressful and demanding situations. The multiple challenges of working in palliative care put health professionals working in this context at the risk of burnout. OBJECTIVES: To examine the evidence on the prevalence of burnout among health professionals working in palliative care. INCLUSION CRITERIA TYPES OF PARTICIPANTS: The current review included studies that encompass qualified health professionals working in palliative care, caring for patients 18 years of age or older...
July 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28705751/single-port-laparoscopy-versus-conventional-laparoscopy-in-benign-adnexal-diseases-a-systematic-review-and-meta-analysis
#12
REVIEW
Andy Schmitt, Patrice Crochet, Sophie Knight, Claire Tourette, Anderson Loundou, Aubert Agostini
Single port laparoscopy (SPL) was developed approximately thirty years ago in minimally invasive surgery. Literature comparing SPL to conventional laparoscopy (CL) for adnexal surgery (cystectomy, adnexectomy) is inconsistent. The objective of this systematic review and meta-analysis was to evaluate the advantage of SPL over CL for adnexal surgery. Pubmed, Embase and Medline were searched for publications in English and in French published between 1975 and November 2015 using the following key words: (((single port) or (single site) or (one port) or (single-port access laparoscopy) or (single-site laparoscopy) or (laparoscopic single site surgery)) and ((adnexal disease) or (ovarian cystectomy) or (ovariectomy) or (adnexectomy))) not (pregnancy)...
July 10, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28705355/growing-educational-differentials-in-the-retreat-from-marriage-among-korean-men
#13
Hyunjoon Park, Jae Kyung Lee
Applying discrete-time hazard models to person-year data constructed from 1% microdata sample of 2010 Korean Census, we explore how men's education affects their transition to first marriage, and how the relationship between education and marriage has changed across three 10-year birth cohorts of Korean men born from 1946 to 1975. Drawing on Oppenheimer's theory of marriage and review of changing educational and economic contexts of Korean men, we develop a hypothesis on growing educational differentials in marriage...
August 2017: Social Science Research
https://www.readbyqxmd.com/read/28696762/composite-dislocations-in-smectic-liquid-crystals
#14
Hillel Aharoni, Thomas Machon, Randall D Kamien
Smectic liquid crystals are characterized by layers that have a preferred uniform spacing and vanishing curvature in their ground state. Dislocations in smectics play an important role in phase nucleation, layer reorientation, and dynamics. Typically modeled as possessing one line singularity, the layer structure of a dislocation leads to a diverging compression strain as one approaches the defect center, suggesting a large, elastically determined melted core. However, it has been observed that for large charge dislocations, the defect breaks up into two disclinations [C...
June 23, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28688390/on-the-calculation-of-resonances-by-analytic-continuation-of-eigenvalues-from-the-stabilization-graph
#15
Idan Haritan, Nimrod Moiseyev
Resonances play a major role in a large variety of fields in physics and chemistry. Accordingly, there is a growing interest in methods designed to calculate them. Recently, Landau et al. proposed a new approach to analytically dilate a single eigenvalue from the stabilization graph into the complex plane. This approach, termed Resonances Via Padé (RVP), utilizes the Padé approximant and is based on a unique analysis of the stabilization graph. Yet, analytic continuation of eigenvalues from the stabilization graph into the complex plane is not a new idea...
July 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28688240/magnesium-status-and-magnesium-therapy-in-cardiac-surgery-a-systematic-review-and-meta-analysis-focusing-on-arrhythmia-prevention
#16
REVIEW
Jessica L Fairley, Ling Zhang, Neil J Glassford, Rinaldo Bellomo
PURPOSE: To investigate magnesium as prophylaxis or treatment of postoperative arrhythmias in cardiac surgery (CS) patients. To assess impact on biochemical and patient-centered outcomes. MATERIALS AND METHODS: We searched MEDLINE, CENTRAL and EMBASE electronic databases from 1975 to October 2015 using terms related to magnesium and CS. English-Language RCTs were included involving adults undergoing CS with parenterally administered magnesium to treat or prevent arrhythmias, compared to control or standard antiarrythmics...
June 21, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28688069/shoreline-change-assessment-using-multi-temporal-satellite-images-a-case-study-of-lake-sapanca-nw-turkey
#17
Umit Duru
The research summarized here determines historical shoreline changes along Lake Sapanca by using Remote Sensing (RS) and Geographical Information Systems (GIS). Six multi-temporal satellite images of Landsat Multispectral Scanner (L1-5 MMS), Enhanced Thematic Mapper Plus (L7 ETM+), and Operational Land Imager Sensors (L8 OLI), covering the period between 17 June 1975 and 15 July 2016, were used to monitor shoreline positions and estimate change rates along the coastal zone. After pre-possessing routines, the Normalized Difference Water Index (NDWI), Modified Normalized Difference Water Index (MNDWI), and supervised classification techniques were utilized to extract six different shorelines...
August 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28687986/insights-from-a-systematic-search-for-information-on-designs-costs-and-effectiveness-of-poliovirus-environmental-surveillance-systems
#18
REVIEW
Radboud J Duintjer Tebbens, Marita Zimmermann, Mark A Pallansch, Kimberly M Thompson
Poliovirus surveillance plays a critical role in achieving and certifying eradication and will play a key role in the polio endgame. Environmental surveillance can provide an opportunity to detect circulating polioviruses prior to the observation of any acute flaccid paralysis cases. We completed a systematic review of peer-reviewed publications on environmental surveillance for polio including the search terms "environmental surveillance" or "sewage," and "polio," "poliovirus," or "poliomyelitis," and compared characteristics of the resulting studies...
July 7, 2017: Food and Environmental Virology
https://www.readbyqxmd.com/read/28683055/two-outbreaks-of-trichinellosis-linked-to-consumption-of-walrus-meat-alaska-2016-2017
#19
Yuri P Springer, Shannon Casillas, Kathryn Helfrich, Deanna Mocan, Marscleite Smith, Gabriela Arriaga, Lyndsey Mixson, Louisa Castrodale, Joseph McLaughlin
During 1975-2012, CDC surveillance identified 1,680 trichinellosis cases in the United States with implicated food items; among these cases, 1,219 were attributed to consumption of raw or pork products, and 461 were attributed to nonpork products. Although trichinellosis in the United States has historically been associated with consumption of pork, multiple nonporcine species of wild game also are competent hosts for Trichinella spp. and have been collectively implicated in the majority of trichinellosis cases since the late 1990s (1-4) (Figure 1)...
July 7, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28682572/carmelo-giordano-1930-2016-a-giant-in-nephrology
#20
Natale De Santo, Carlo De Pascale, Ernesto Quarto, Malcolm E Phillips, Biagio Di Iorio
Carmelo Giordano (Carmine, Louis, Joseph Giordano) was born in Naples on August 23, 1930 in the house of Rafael and Anna Tirone He received the MD cum laude in 1954. He was Fellow and assistant to Professor Flaviano Magrassi and studied nephrology at the Peter Bent Brigham Hospital, University of Harvard in Boston, under the guidance of John P. Merrill (1958-1960). He was nominated Professor of Nephrology at the University Federico II, Naples in 1975 and Professor of Medicine at the Second University of Naples (1986-2002)...
April 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
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