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https://www.readbyqxmd.com/read/28330587/comparison-of-semi-automated-and-manual-methods-to-measure-the-volume-of-prostate-cancer-on-magnetic-resonance-imaging
#1
L Marin, M Ezziane, E Comperat, P Mozer, G Cancel-Tassin, J-F Coté, D Racoceanu, F Boudghene, O Lucidarme, O Cussenot, R Renard Penna
PURPOSE: The purpose of this study was to determine the accuracy of manual semi-automated and volumetric measurements to assess prostate cancer volume on multiparametric magnetic resonance imaging (MP-MRI) using whole-mount histopathology for validation. MATERIALS AND METHODS: We evaluated 30 consecutive men (median age, 65.7 years; interquartile range [IQR], 61.5-70.9 years) with a median prostatic specific antigen of 8.5ng/dL (IQR, 5.5-10.5ng/dL), who underwent MP-MRI before radical prostatectomy...
March 15, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28289941/development-and-validation-of-a-logistic-regression-model-to-distinguish-transition-zone-cancers-from-benign-prostatic-hyperplasia-on-multi-parametric-prostate-mri
#2
Yuji Iyama, Takeshi Nakaura, Kazuhiro Katahira, Ayumi Iyama, Yasunori Nagayama, Seitaro Oda, Daisuke Utsunomiya, Yasuyuki Yamashita
PURPOSE: To develop a prediction model to distinguish between transition zone (TZ) cancers and benign prostatic hyperplasia (BPH) on multi-parametric prostate magnetic resonance imaging (mp-MRI). MATERIALS AND METHODS: This retrospective study enrolled 60 patients with either BPH or TZ cancer, who had undergone 3 T-MRI. We generated ten parameters for T2-weighted images (T2WI), diffusion-weighted images (DWI) and dynamic MRI. Using a t-test and multivariate logistic regression (LR) analysis to evaluate the parameters' accuracy, we developed LR models...
March 13, 2017: European Radiology
https://www.readbyqxmd.com/read/28256901/diagnosis-of-typical-and-atypical-transitional-zone-prostate-cancer-and-its-mimics-at-multiparametric-prostate-mri
#3
Jinxing Yu, Ann S Fulcher, Sarah G Winks, Mary A Turner, Ryan D Clayton, Michael Brooks, Sean Li
Many of the current clinical screening methods for prostate cancer (PCa) such as prostate specific antigen (PSA) testing or trans-rectal ultrasound (TRUS)-guided prostate biopsy lack sensitivity and specificity for diagnosis of PCa of the transition zone (TZ). Recent technical advances in multiparametric-MRI (mp-MRI) have markedly improved detection of PCa of the TZ. However, there are many diagnostic challenges we still encounter in our daily practice that compromise the accuracy of the diagnosis. By performing both MRI-guided and US/MRI fusion-guided biopsies, we have gained extensive experience in the diagnosis of PCa of the TZ...
March 3, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28246496/1-5-tesla-multiparametric-magnetic-resonance-imaging-for-the-detection-of-clinically-significant-prostate-cancer
#4
Cristian Popita, Anca Raluca Popita, Adela Sitar-Taut, Bogdan Petrut, Bogdan Fetica, Ioan Coman
BACKGROUND AND AIM: Multiparametric-magnetic resonance imaging (mp-MRI) is the main imaging modality used for prostate cancer detection. The aim of this study is to evaluate the diagnostic performance of mp-MRI at 1.5-Tesla (1.5-T) for the detection of clinically significant prostate cancer. METHODS: In this ethical board approved prospective study, 39 patients with suspected prostate cancer were included. Patients with a history of positive prostate biopsy and patients treated for prostate cancer were excluded...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/28238033/clinical-and-multiparametric-mri-signatures-of-granulomatous-prostatitis
#5
Soroush Rais-Bahrami, Jeffrey W Nix, Baris Turkbey, Jason A Pietryga, Rupan Sanyal, John V Thomas, Jennifer B Gordetsky
PURPOSE: The purpose of the study is to differentiate granulomatous prostatitis (GP) from high-grade prostate cancer (PCa) based on clinical findings and imaging characteristics on multiparametric MRI (MP-MRI). METHODS: Pathology from patients undergoing MRI/US fusion-guided prostate biopsies between 2014 and 2015 was reviewed. Five patients with biopsy proven GP were identified as well as 15 patients with biopsy-proven Gleason score ≥4 + 3 = 7 PCa. Patients were matched for age, serum PSA level, and prebiopsy-assigned MP-MRI cancer suspicion scores...
February 25, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28237429/prostate-mri-for-brachytherapists-anatomy-and-technique
#6
A M Venkatesan, R J Stafford, C Duran, P D Soni, A Berlin, P W McLaughlin
PURPOSE: To present an overview of mp MRI techniques necessary for high-resolution imaging of prostate. METHODS: We summarize examples from our clinical experience and concepts from the current literature that illustrate normal prostate anatomy on multiparametric MRI (mp MRI). RESULTS: Our experience regarding optimal mp MRI image acquisition is provided, as well as a summary of prostate and periprostatic anatomy and anatomical variants that pose challenges for BT...
February 23, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28236452/multiparametric-magnetic-resonance-imaging-and-prostate-cancer-what-s-new
#7
V Catalá, J C Vilanova, J M Gaya, F Algaba, T Martí
Prostatic multi-parametric magnetic resonance imaging (MP-MRI) has recently had a wide development becoming a key tool in the diagnostic and therapeutic decisions in prostate cancer (Pca). The fast development both in technology and in reading (PIRADS V2) requires a continuous updating of knowledge within this area. The aim of this article is to present an updated revision of technical aspects, reading patterns and prostatic MP-MRI in Pca, with a multidisciplinary approach. Currently guidelines establish the use of the MP-MRI when there is a high PSA and a negative prostatic biopsy; tumor staging; evaluation in candidates to active surveillance; focal treatments plans and tumoral recurrence evaluation...
February 21, 2017: Radiología
https://www.readbyqxmd.com/read/28194505/adenomatous-dominant-benign-prostatic-hyperplasia-adbph-as-a-predictor-for-clinical-success-following-prostate-artery-embolization-an-age-matched-case-control-study
#8
M W Little, P Boardman, A C Macdonald, N Taylor, R Macpherson, J Crew, C R Tapping
PURPOSE: To investigate the clinical impact of performing prostate artery embolization (PAE) on patients with adenomatous-dominant benign prostatic hyperplasia (AdBPH). MATERIALS AND METHODS: Twelve patients from the ongoing proSTatic aRtery EmbolizAtion for the treatMent of benign prostatic hyperplasia (STREAM) trial were identified as having AdBPH; defined as two or more adenomas within the central gland of ≥1 cm diameter on multi-parametric MRI (MP-MRI). These patients were age-matched with patients from the STREAM cohort, without AdBPH...
February 13, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28182304/benign-prostatic-hyperplasia-after-prostatic-arterial-embolization-in-a-canine-model-a-3t-multiparametric-mri-and-whole-mount-step-section-pathology-correlated-longitudinal-study
#9
Basen Li, Anhui Xu, Nan Wang, Xiangde Min, Zhaoyan Feng, Ming Deng, Liang Li, Jie Cai, Zhen Kang, Kehua Jiang, Dong Kuang, Liang Wang
PURPOSE: To explore the morphological and functional characteristics of prostatic arterial embolization (PAE) in a canine model of benign prostatic hyperplasia (BPH) with 3T multiparametric magnetic resonance imaging (mp-MRI) and whole-mount step-section pathology correlation. MATERIALS AND METHODS: Eight adult male beagle dogs with hormone-induced BPH underwent 3T mp-MRI before and 1, 3, and 6 months after PAE, with subsequent whole-mount step-section pathologic assessment...
February 9, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28169303/prostate-cancer-improving-diagnosis-can-mp-mri-fulfil-its-promis
#10
David Killock
No abstract text is available yet for this article.
March 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28157066/multiparametric-mri-in-detection-and-staging-of-prostate-cancer
#11
REVIEW
Lars Boesen
BACKGROUND: Prostate cancer (PCa) is the second leading cause of cancer-related mortality and the most frequently diagnosed male malignant disease among men in the Nordic countries. The manifestation of PCa ranges from indolent to highly aggressive disease and due to this high variation in PCa progression, the diagnosis and subsequent treatment planning can be challenging. The current diagnostic approach with PSA testing and digital rectal examination followed by transrectal ultrasound biopsies (TRUS-bx) lack in both sensitivity and specificity in PCa detection and offers limited information about the aggressiveness and stage of the cancer...
February 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28144814/intravoxel-incoherent-motion-ivim-%C3%A2-diffusion-weighted-imaging-dwi-in-the-periferic-prostate-cancer-detection-and-stratification
#12
Filippo Pesapane, Francesca Patella, Enrico Maria Fumarola, Silvia Panella, Anna Maria Ierardi, Giovanni Guido Pompili, Giuseppe Franceschelli, Salvatore Alessio Angileri, Alberto Magenta Biasina, Gianpaolo Carrafiello
The aim of this study was to compare the Intravoxel Incoherent Motion (IVIM) parameters between healthy Peripheral Zone (PZ), Benign Prostatic Hyperplasia (BPH) and Prostate Cancer (PCa) and compare them to assess whether there was correlation with Gleason Score (GS) grading system. Thirty-one patients with suspect of PCa underwent 1.5T Multi-Parametric Magnetic Resonance Imaging (MP-MRI) with endorectal coil with a protocol including T2WI, DWI using 10 b values (0, 10, 20, 30, 50, 80, 100, 200, 400, 1000 s/mm(2)) and DCE...
March 2017: Medical Oncology
https://www.readbyqxmd.com/read/28143868/pre-biopsy-mp-mri-can-help-to-improve-the-predictive-performance-in-prostate-cancer-a-prospective-study-in-1478-consecutive-patients
#13
Rui Wang, Jing Wang, Ge Gao, Juan Hu, Yuanyuan Jiang, Zhenlong Zhao, Xiaodong Zhang, Yu-Dong Zhang, Xiaoying Wang
PURPOSE: To investigate whether pre-biopsy multi-parametric (mp) MRI can help to improve predictive performance in prostate cancer (PCa). EXPERIMENTAL DESIGN: Based on a support vector machine (SVM) analysis, we prospectively modeled clinical data (age, PSA, DRE, TRUS, PSA density and prostate volume) and mp-MRI findings (PI-RADS score and TNM stage) on 985 men to predict the risk of PCa. The new nomogram was validated on 493 patients treated at a same institution...
January 31, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28143433/developing-a-nomogram-based-on-multiparametric-magnetic-resonance-imaging-for-forecasting-high-grade-prostate-cancer-to-reduce-unnecessary-biopsies-within-the-prostate-specific-antigen-gray-zone
#14
Xiang-Ke Niu, Jun Li, Susant Kumar Das, Yan Xiong, Chao-Bing Yang, Tao Peng
BACKGROUND: Since 1980s the application of Prostate specific antigen (PSA) brought the revolution in prostate cancer diagnosis. However, it is important to underline that PSA is not the ideal screening tool due to its low specificity, which leads to the possible biopsy for the patient without High-grade prostate cancer (HGPCa). Therefore, the aim of this study was to establish a predictive nomogram for HGPCa in patients with PSA 4-10 ng/ml based on Prostate Imaging Reporting and Data System version 2 (PI-RADS v2), MRI-based prostate volume (PV), MRI-based PV-adjusted Prostate Specific Antigen Density (adjusted-PSAD) and other traditional classical parameters...
February 1, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28140460/factors-predicting-prostate-cancer-upgrading-on-magnetic-resonance-imaging-targeted-biopsy-in-an-active-surveillance-population
#15
Win Shun Lai, Jennifer B Gordetsky, John V Thomas, Jeffrey W Nix, Soroush Rais-Bahrami
BACKGROUND: The objective of this study was to create a nomogram model integrating clinical and multiparametric magnetic resonance imaging (MP-MRI)-based variables to predict prostate cancer upgrading in a population of active surveillance (AS) patients. METHODS: Prostate cancer patients on AS who underwent MP-MRI with magnetic resonance imaging (MRI)/ultrasound (US) fusion-guided biopsy were identified. Clinical and imaging variables, including the prostate-specific antigen density (PSAD), number of lesions, total lesion volume, total lesion density, Prostate Imaging Reporting and Data System magnetic resonance imaging suspicion score (MRI-SS), and duration between prereferral systematic and MRI/US fusion-guided biopsy sessions, were assessed...
January 31, 2017: Cancer
https://www.readbyqxmd.com/read/28139419/prostate-mri-for-brachytherapists-diagnosis-imaging-pitfalls-and-post-therapy-assessment
#16
REVIEW
A M Venkatesan, R J Stafford, C Duran, P D Soni, A Berlin, P W McLaughlin
Optimal integration of multiparametric MRI (mp MRI) into prostate brachytherapy practice necessitates an understanding of imaging findings pertinent to prostate cancer detection and staging. This review will summarize prostate cancer imaging findings and tumor staging on mp MRI, including an overview of the Prostate Imaging Reporting and Data System (PIRADS)-structured reporting schema, mp MRI findings observed in the post-therapy setting including cases of post-treatment recurrence, and MRI concepts integral to successful salvage brachytherapy...
January 27, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28111879/detection-of-prostate-cancer-using-magnetic-resonance-imaging-ultrasonography-image-fusion-targeted-biopsy-in-african-american-men
#17
Toshitaka Shin, Thomas B Smyth, Osamu Ukimura, Nariman Ahmadi, Andre Luis de Castro Abreu, Masakatsu Oishi, Hiromitsu Mimata, Inderbir S Gill
OBJECTIVE: To assess the diagnostic yield of targeted prostate biopsy in African-American (A-A) men using image fusion of multi-parametric magnetic resonance imaging (mpMRI) with real-time transrectal ultrasonography (US). PATIENTS AND METHODS: We retrospectively analysed 661 patients (117 A-A and 544 Caucasian) who had mpMRI before biopsy and then underwent MRI/US image-fusion targeted biopsy (FTB) between October 2012 and August 2015. The mpMRIs were reported on a 5-point Likert scale of suspicion...
January 23, 2017: BJU International
https://www.readbyqxmd.com/read/28110982/diagnostic-accuracy-of-multi-parametric-mri-and-trus-biopsy-in-prostate-cancer-promis-a-paired-validating-confirmatory-study
#18
Hashim U Ahmed, Ahmed El-Shater Bosaily, Louise C Brown, Rhian Gabe, Richard Kaplan, Mahesh K Parmar, Yolanda Collaco-Moraes, Katie Ward, Richard G Hindley, Alex Freeman, Alex P Kirkham, Robert Oldroyd, Chris Parker, Mark Emberton
BACKGROUND: Men with high serum prostate specific antigen usually undergo transrectal ultrasound-guided prostate biopsy (TRUS-biopsy). TRUS-biopsy can cause side-effects including bleeding, pain, and infection. Multi-parametric magnetic resonance imaging (MP-MRI) used as a triage test might allow men to avoid unnecessary TRUS-biopsy and improve diagnostic accuracy. METHODS: We did this multicentre, paired-cohort, confirmatory study to test diagnostic accuracy of MP-MRI and TRUS-biopsy against a reference test (template prostate mapping biopsy [TPM-biopsy])...
February 25, 2017: Lancet
https://www.readbyqxmd.com/read/28055249/volumetry-of-the-dominant-intraprostatic-tumour-lesion-intersequence-and-interobserver-differences-on-multiparametric-mri
#19
Hugh Harvey, Matthew R Orton, Veronica A Morgan, Chris Parker, David Dearnaley, Cyril Fisher, Nandita M deSouza
OBJECTIVES: To establish interobserver reproducibility of tumour volumetry on individual multiparametric(mp) prostate MRI sequences, validate measurements with histology and determine whether functional to morphological volume ratios reflect Gleason score. METHODS: Forty-one men with prostate cancer treated with prostatectomy (cohort 1) or radical radiotherapy (cohort 2) who had pre-treatment mp (T2-W, DW-, DCE-) MRI were studied retrospectively. Dominant intraprostatic lesions (DIPLs) were manually delineated on each sequence and volumes compared between observers (n=40 analysable) and with radical prostatectomy (n=20)...
January 5, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28048498/we-ab-202-12-voxel-wise-analysis-of-apparent-diffusion-coefficient-and-perfusion-maps-in-multi-parametric-mri-of-prostate-cancer
#20
K Engstroem, O Casares-Magaz, J Roervik, E Andersen, L Muren
PURPOSE: Multi-parametric MRI (mp-MRI) is being introduced in radiotherapy (RT) of prostate cancer, including for tumour delineation in focal boosting strategies. We recently developed an image-based tumour control probability model, based on cell density distributions derived from apparent diffusion coefficient (ADC) maps. Beyond tumour volume and cell densities, tumour hypoxia is also an important determinant of RT response. Since tissue perfusion from mp-MRI has been related to hypoxia we have explored the patterns of ADC and perfusion maps, and the relations between them, inside and outside prostate index lesions...
June 2016: Medical Physics
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