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https://www.readbyqxmd.com/read/28055249/volumetry-of-the-dominant-intraprostatic-tumour-lesion-intersequence-and-interobserver-differences-on-multiparametric-mri
#1
Hugh Harvey, Matthew R Orton, Veronica A Morgan, Chris Parker, David Dearnaley, Cyril Fisher, Nandita M deSouza
OBJECTIVES: To establish interobserver reproducibility of tumour volumetry on individual multiparametric(mp) prostate MRI sequences, validate measurements with histology and determine whether functional to morphological volume ratios reflect Gleason score. METHODS: Forty-one men with prostate cancer treated with prostatectomy (cohort 1) or radical radiotherapy (cohort 2) who had pre-treatment mp (T2-W, DW-, DCE-) MRI were studied retrospectively. Dominant intraprostatic lesions (DIPLs) were manually delineated on each sequence and volumes compared between observers (n=40 analysable) and with radical prostatectomy (n=20)...
January 5, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28048498/we-ab-202-12-voxel-wise-analysis-of-apparent-diffusion-coefficient-and-perfusion-maps-in-multi-parametric-mri-of-prostate-cancer
#2
K Engstroem, O Casares-Magaz, J Roervik, E Andersen, L Muren
PURPOSE: Multi-parametric MRI (mp-MRI) is being introduced in radiotherapy (RT) of prostate cancer, including for tumour delineation in focal boosting strategies. We recently developed an image-based tumour control probability model, based on cell density distributions derived from apparent diffusion coefficient (ADC) maps. Beyond tumour volume and cell densities, tumour hypoxia is also an important determinant of RT response. Since tissue perfusion from mp-MRI has been related to hypoxia we have explored the patterns of ADC and perfusion maps, and the relations between them, inside and outside prostate index lesions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047097/we-fg-206-09-association-of-prostate-volumes-with-restricted-diffusion-and-prostate-cancer-aggressiveness
#3
Y Tschudi
PURPOSE: To create an automatic workflow for evaluation of thresholds of restricted diffusion, based on Apparent Diffusion Coefficient (ADC) values in multiparametric (mp)MRI of the prostate. To investigate the association of these volumes with biopsy Gleason Score (GS). METHODS: Patients with prostate cancer, imaged on 3T Discovery MR750 (GE, Waukesha, WI) magnet were selected from departmental database based on the presence of mpMRI exam. All subsequent analyses were performed using Java plugins in MIM (MIM, Cleveland, Ohio)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046902/su-d-207a-03-potential-role-of-bold-mri-in-discrimination-of-aggressive-tumor-habitat-in-prostate-cancer
#4
J Ford, C Lopez, Y Tschudi, A Breto, K Padgett, A Pollack, R Stoyanova
PURPOSE: To determine whether blood oxygenation level dependent (BOLD) MRI signal measured in prostate cancer patients, in addition to quantitative diffusion and perfusion parameters from multiparametric (mp)MRI exams, can help discriminate aggressive and/or radioresistant lesions. METHODS: Several ongoing clinical trials in our institution require mpMRI exam to determine eligibility (presence of identifiable tumor lesion on mpMRI) and prostate volumes for dose escalation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039927/multi-center-validation-of-prostate-tumor-localization-using-multi-parametric-mri-and-prior-knowledge
#5
Cuong Viet Dinh, Peter Steenbergen, Ghazaleh Ghobadi, Henk van der Poel, Stijn W T P J Heijmink, Jeroen de Jong, Sofie Isebaert, Karin Haustermans, Evelyne Lerut, Raymond Oyen, Yangming Ou, Davatzikos Christos, Uulke A van der Heide
PURPOSE: Tumor localization provides crucial information for radiotherapy dose differentiation treatments, such as focal dose escalation and dose painting by numbers, which aim at achieving tumor control with minimal side effects. Multi-parametric (mp-)MRI is increasingly used for tumor detection and localization in prostate because of its ability to visualize tissue structure and to reveal tumor characteristics. However, it can be challenging to distinguish cancer, particularly in the transition zone...
December 31, 2016: Medical Physics
https://www.readbyqxmd.com/read/28008754/risk-factors-for-gleason-score-upgrading-following-radical-prostatectomy-a-review-of-the-current-literature
#6
David R Alchin, Declan Murphy, Nathan Lawrentschuk
INTRODUCTION: Gleason score discordance can confound optimal treatment allocation of patients diagnosed with prostate cancer and place these patients at risk of worse oncological outcomes. Its prevalence remains endemic; its exact causation remains unknown. The objective of this review was to examine the observational studies of patient cohorts who have undergone radical prostatectomy with the aim of identifying any preoperative variables that may be associated with an upgrade in final prostatectomy Gleason score...
December 22, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27842676/biparametric-3t-magentic-resonance-imaging-for-prostatic-cancer-detection-in-a-biopsy-na%C3%A3-ve-patient-population-a-further-improvement-of-pi-rads-v2
#7
COMPARATIVE STUDY
Arnaldo Stanzione, Massimo Imbriaco, Sirio Cocozza, Ferdinando Fusco, Giovanni Rusconi, Carmela Nappi, Vincenzo Mirone, Francesco Mangiapia, Arturo Brunetti, Alfonso Ragozzino, Nicola Longo
OBJECTIVES: To prospectively determine the diagnostic accuracy of a biparametric 3T magnetic resonance imaging protocol (BP-MRI) for prostatic cancer detection, compared to a multiparametric MRI protocol (MP-MRI), in a biopsy naïve patient population. METHODS: Eighty-two untreated patients (mean age 65±7.6years) with clinical suspicion of prostate cancer and/or altered prostate-specific antigen (PSA) levels underwent a MP-MRI, including T2-weighted imaging, diffusion-weighted imaging (with the correspondent apparent diffusion coefficient maps) and dynamic contrast enhanced sequence, followed by prostate biopsy...
December 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27800057/comparison-of-prostate-mri-3d-transrectal-ultrasound-fusion-biopsy-for-first-time-and-repeat-biopsy-patients-with-previous-atypical-small-acinar-proliferation
#8
Derek W Cool, Cesare Romagnoli, Jonathan I Izawa, Joseph Chin, Lori Gardi, David Tessier, Ashley Mercado, Jonathan Mandel, Aaron D Ward, Aaron Fenster
INTRODUCTION: This study evaluates the clinical benefit of magnetic resonance-transrectal ultrasound (MR-TRUS) fusion biopsy over systematic biopsy between first-time and repeat prostate biopsy patients with prior atypical small acinar proliferation (ASAP). MATERIALS: 100 patients were enrolled in a single-centre prospective cohort study: 50 for first biopsy, 50 for repeat biopsy with prior ASAP. Multiparameteric magnetic resonance imaging (MP-MRI) and standard 12-core ultrasound biopsy (Std-Bx) were performed on all patients...
September 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27769214/innovate-a-prospective-cohort-study-combining-serum-and-urinary-biomarkers-with-novel-diffusion-weighted-magnetic-resonance-imaging-for-the-prediction-and-characterization-of-prostate-cancer
#9
Edward Johnston, Hayley Pye, Elisenda Bonet-Carne, Eleftheria Panagiotaki, Dominic Patel, Myria Galazi, Susan Heavey, Lina Carmona, Alexander Freeman, Giorgia Trevisan, Clare Allen, Alexander Kirkham, Keith Burling, Nicola Stevens, David Hawkes, Mark Emberton, Caroline Moore, Hashim U Ahmed, David Atkinson, Manuel Rodriguez-Justo, Tony Ng, Daniel Alexander, Hayley Whitaker, Shonit Punwani
BACKGROUND: Whilst multi-parametric magnetic resonance imaging (mp-MRI) has been a significant advance in the diagnosis of prostate cancer, scanning all patients with elevated prostate specific antigen (PSA) levels is considered too costly for widespread National Health Service (NHS) use, as the predictive value of PSA levels for significant disease is poor. Despite the fact that novel blood and urine tests are available which may predict aggressive disease better than PSA, they are not routinely employed due to a lack of clinical validity studies...
October 21, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27766349/multi-parametric-mr-imaging-of-the-anterior-fibromuscular-stroma-and-its-differentiation-from-prostate-cancer
#10
Emily Ward, Michael Baad, Yahui Peng, Ambereen Yousuf, Shiyang Wang, Tatjana Antic, Aytekin Oto
PURPOSE: To describe MP-MRI features of the normal anterior fibromuscular stroma (AFMS) and identify MR imaging findings that can differentiate it from anterior prostate cancer. METHODS: We reviewed MP-MR images and histopathology of patients who underwent pre-operative MRI and prostatectomy between October 2012 and August 2014. Thirty-seven patients with anterior prostate cancer larger than 5 mm and 40 patients with no anterior cancer were included in this study...
October 21, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27760657/-application-evaluation-of-multi-parametric-mri-in-the-diagnosis-and-differential-diagnosis-of-early-prostate-cancer-and-prostatitis
#11
P Li, Y Huang, Y Li, L Cai, G H Ji, Y Zheng, Z Q Chen
Objective: To evaluate the value of multi-parametric MRI (Mp-MRI) in the diagnosis and differential diagnosis of early prostate cancer(PCa) in the peripheral zone(PZ) and low T2WI signal intensity of prostatitis. Methods: A total of 40 patients with PZ early PCa and 37 with prostatitis of hypointense T2WI signal in PZ were retrospectively analyzed, which were collected from the General Hospital of Ningxia Medical University from Janurary 2009 to June 2015, who underwent T2WI, DWI, and DCE-MRI examination and all patients were confirmed by pathology...
October 11, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27748338/prostate-cancer-detection-with-multiparametric-magnetic-resonance-imaging-prostate-imaging-reporting-and-data-system-version-1-versus-version-2
#12
Zhao-Yan Feng, Liang Wang, Xiang-De Min, Shao-Gang Wang, Guo-Ping Wang, Jie Cai
BACKGROUND: Prostate Imaging Reporting and Data System (PI-RADS) is a globally acceptable standardization for multiparametric magnetic resonance imaging (mp-MRI) in prostate cancer (PCa) diagnosis. The American College of Radiology revised the PI-RADS to address the limitations of version 1 in December 2014. This study aimed to determine whether the PI-RADS version 2 (PI-RADS v2) scoring system improves the diagnostic accuracy of mp-MRI of the prostate compared with PI-RADS v1. METHODS: This retrospective study was approved by the institutional review board...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27726850/dynamic-contrast-enhanced-imaging-has-limited-added-value-over-t2-weighted-imaging-and-diffusion-weighted-imaging-when-using-pi-radsv2-for-diagnosis-of-clinically-significant-prostate-cancer-in-patients-with-elevated-psa
#13
P De Visschere, N Lumen, P Ost, K Decaestecker, E Pattyn, G Villeirs
AIM: To determine the added value of dynamic contrast-enhanced imaging (DCE) over T2-weighted imaging (T2-WI) and diffusion-weighted imaging (DWI) for detection of clinically significant prostate cancer (csPC) in patients with elevated prostate-specific antigen (PSA). METHODS AND MATERIALS: Two hundred and forty-five patients with elevated PSA underwent multiparametric (mp) magnetic resonance imaging (MRI) of the prostate before biopsy. mpMRI was performed using a 3 T MRI system without an endorectal coil...
January 2017: Clinical Radiology
https://www.readbyqxmd.com/read/27613356/magnetic-resonance-imaging-transrectal-ultrasound-guided-fusion-biopsy-to-detect-progression-in-patients-with-existing-lesions-on-active-surveillance-for-low-and-intermediate-risk-prostate-cancer
#14
Thomas P Frye, Arvin K George, Amichai Kilchevsky, Mahir Maruf, M Minhaj Siddiqui, Michael Kongnyuy, Akhil Muthigi, Hui Han, Howard L Parnes, Maria Merino, Peter L Choyke, Baris Turkbey, Brad Wood, Peter A Pinto
PURPOSE: Active surveillance is an established option for men with low risk prostate cancer. Multiparametric magnetic resonance imaging with magnetic resonance imaging-transrectal ultrasound fusion guided biopsy may better identify patients for active surveillance compared to systematic 12-core biopsy due to improved risk stratification. To our knowledge the performance of multiparametric magnetic resonance imaging in following men on active surveillance with visible lesions is unknown...
September 6, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27583170/biparametric-versus-multiparametric-mri-in-the-diagnosis-of-prostate-cancer
#15
Karen Cecilie Duus Thestrup, Vibeke Logager, Ingerd Baslev, Jakob M Møller, Rasmus Hvass Hansen, Henrik S Thomsen
BACKGROUND: Since multiparametric magnetic resonance imaging (mp-MRI) of the prostate exceeds 30 min, minimizing the evaluation time of significant (Gleason scores > 6) prostate cancer (PCa) would be beneficial. A reduced protocol might be sufficient for the diagnosis. PURPOSE: To study whether a short unenhanced biparametric MRI (bp-MRI) matches mp-MRI in detecting significant PCa. MATERIAL AND METHODS: A total of 204 men (median age, 65 years; mean ± SD, 64...
August 2016: Acta Radiologica Open
https://www.readbyqxmd.com/read/27564265/development-and-comparison-of-a-chinese-nomogram-adding-multi-parametric-mri-information-for-predicting-extracapsular-extension-of-prostate-cancer
#16
Yuke Chen, Wei Yu, Yu Fan, Liqun Zhou, Yang Yang, Huihui Wang, Yuan Jiang, Xiaoying Wang, Shiliang Wu, Jie Jin
PURPOSE: To improve the performation of a nomogram for predicting side-specific extracapsular extension (SS-ECE). RESULTS: One hundred and ninety-six patients (55.5%) had ECE on final pathology. Bilateral and unilateral ECE rate was 13.9% (49/353) and 41.6% (147/353), respectively. The mean age was 65.9 years and the mean serum prostate specific antigen (PSA) was 15.0 ng/ml. Based on multivariate logistic regression analysis, clinical stage (cStage), PSA, Gleason sum, percentage of positive cores, and ECE risk score were significant predictors of ECE...
August 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27532112/prostate-cancer-detection-using-multiparametric-3-tesla-mri-and-fusion-biopsy-preliminary-results
#17
Thais Caldara Mussi, Rodrigo Gobbo Garcia, Marcos Roberto Gomes Queiroz, Gustavo Caserta Lemos, Ronaldo Hueb Baroni
OBJECTIVE: To evaluate the diagnostic efficacy of transrectal ultrasonography (US) bi¬opsy with imaging fusion using multiparametric (mp) magnetic resonance imaging (MRI) in patients with suspicion of prostate cancer (PCa), with an emphasis on clini¬cally significant tumors according to histological criteria. MATERIALS AND METHODS: A total of 189 consecutive US/MRI fusion biopsies were per¬formed obtaining systematic and guided samples of suspicious areas on mpMRI using a 3 Tesla magnet without endorectal coil...
September 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27530436/transperineal-versus-transrectal-mri-trus-fusion-targeted-biopsy-detection-rate-of-clinically-significant-prostate-cancer
#18
Pietro Pepe, Antonio Garufi, Giandomenico Priolo, Michele Pennisi
INTRODUCTION: To evaluate the detection rate for clinically significant prostate cancer (PCa) of transperineal (TP) versus transrectal (TR) multiparametric (mp) magnetic resonance imaging (MRI)/transrectal ultrasound-guided (TRUS) fusion targeted biopsy. PATIENTS AND METHODS: From January 2015 to January 2016, a total of 200 men (median age, 61 years) with negative digital rectal examination findings underwent repeat saturation TP prostate biopsy (SPBx; median 30 cores) for increasing or persistent elevated prostate-specific antigen values...
July 21, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27438142/association-of-multiparametric-mri-quantitative-imaging-features-with-prostate-cancer-gene-expression-in-mri-targeted-prostate-biopsies
#19
Radka Stoyanova, Alan Pollack, Mandeep Takhar, Charles Lynne, Nestor Parra, Lucia L C Lam, Mohammed Alshalalfa, Christine Buerki, Rosa Castillo, Merce Jorda, Hussam Al-Deen Ashab, Oleksandr N Kryvenko, Sanoj Punnen, Dipen J Parekh, Matthew C Abramowitz, Robert J Gillies, Elai Davicioni, Nicholas Erho, Adrian Ishkanian
Standard clinicopathological variables are inadequate for optimal management of prostate cancer patients. While genomic classifiers have improved patient risk classification, the multifocality and heterogeneity of prostate cancer can confound pre-treatment assessment. The objective was to investigate the association of multiparametric (mp)MRI quantitative features with prostate cancer risk gene expression profiles in mpMRI-guided biopsies tissues.Global gene expression profiles were generated from 17 mpMRI-directed diagnostic prostate biopsies using an Affimetrix platform...
August 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27383502/optimal-high-b-value-for-diffusion-weighted-mri-in-diagnosing-high-risk-prostate-cancers-in-the-peripheral-zone
#20
Harsh K Agarwal, Francesca V Mertan, Sandeep Sankineni, Marcelino Bernardo, Julien Senegas, Jochen Keupp, Dagane Daar, Maria Merino, Bradford J Wood, Peter A Pinto, Peter L Choyke, Baris Turkbey
PURPOSE: To retrospectively determine the optimal b-value(s) of diffusion-weighted imaging (DWI) associated with intermediate-high risk cancer in the peripheral zone (PZ) of the prostate. MATERIALS AND METHODS: Forty-two consecutive patients underwent multi b-value (16 evenly spaced b-values between 0 and 2000 s/mm(2) ) DWI along with multi-parametric MRI (MP-MRI) of the prostate at 3 Tesla followed by trans-rectal ultrasound/MRI fusion guided targeted biopsy of suspicious lesions detected at MP-MRI...
January 2017: Journal of Magnetic Resonance Imaging: JMRI
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