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mp MRI prostate

Arnaldo Stanzione, Massimo Imbriaco, Sirio Cocozza, Ferdinando Fusco, Giovanni Rusconi, Carmela Nappi, Vincenzo Mirone, Francesco Mangiapia, Arturo Brunetti, Alfonso Ragozzino, Nicola Longo
OBJECTIVES: To prospectively determine the diagnostic accuracy of a biparametric 3T magnetic resonance imaging protocol (BP-MRI) for prostatic cancer detection, compared to a multiparametric MRI protocol (MP-MRI), in a biopsy naïve patient population. METHODS: Eighty-two untreated patients (mean age 65±7.6years) with clinical suspicion of prostate cancer and/or altered prostate-specific antigen (PSA) levels underwent a MP-MRI, including T2-weighted imaging, diffusion-weighted imaging (with the correspondent apparent diffusion coefficient maps) and dynamic contrast enhanced sequence, followed by prostate biopsy...
December 2016: European Journal of Radiology
Derek W Cool, Cesare Romagnoli, Jonathan I Izawa, Joseph Chin, Lori Gardi, David Tessier, Ashley Mercado, Jonathan Mandel, Aaron D Ward, Aaron Fenster
INTRODUCTION: This study evaluates the clinical benefit of magnetic resonance-transrectal ultrasound (MR-TRUS) fusion biopsy over systematic biopsy between first-time and repeat prostate biopsy patients with prior atypical small acinar proliferation (ASAP). MATERIALS: 100 patients were enrolled in a single-centre prospective cohort study: 50 for first biopsy, 50 for repeat biopsy with prior ASAP. Multiparameteric magnetic resonance imaging (MP-MRI) and standard 12-core ultrasound biopsy (Std-Bx) were performed on all patients...
September 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Edward Johnston, Hayley Pye, Elisenda Bonet-Carne, Eleftheria Panagiotaki, Dominic Patel, Myria Galazi, Susan Heavey, Lina Carmona, Alexander Freeman, Giorgia Trevisan, Clare Allen, Alexander Kirkham, Keith Burling, Nicola Stevens, David Hawkes, Mark Emberton, Caroline Moore, Hashim U Ahmed, David Atkinson, Manuel Rodriguez-Justo, Tony Ng, Daniel Alexander, Hayley Whitaker, Shonit Punwani
BACKGROUND: Whilst multi-parametric magnetic resonance imaging (mp-MRI) has been a significant advance in the diagnosis of prostate cancer, scanning all patients with elevated prostate specific antigen (PSA) levels is considered too costly for widespread National Health Service (NHS) use, as the predictive value of PSA levels for significant disease is poor. Despite the fact that novel blood and urine tests are available which may predict aggressive disease better than PSA, they are not routinely employed due to a lack of clinical validity studies...
October 21, 2016: BMC Cancer
Emily Ward, Michael Baad, Yahui Peng, Ambereen Yousuf, Shiyang Wang, Tatjana Antic, Aytekin Oto
PURPOSE: To describe MP-MRI features of the normal anterior fibromuscular stroma (AFMS) and identify MR imaging findings that can differentiate it from anterior prostate cancer. METHODS: We reviewed MP-MR images and histopathology of patients who underwent pre-operative MRI and prostatectomy between October 2012 and August 2014. Thirty-seven patients with anterior prostate cancer larger than 5 mm and 40 patients with no anterior cancer were included in this study...
October 21, 2016: Abdominal Radiology
P Li, Y Huang, Y Li, L Cai, G H Ji, Y Zheng, Z Q Chen
Objective: To evaluate the value of multi-parametric MRI (Mp-MRI) in the diagnosis and differential diagnosis of early prostate cancer(PCa) in the peripheral zone(PZ) and low T2WI signal intensity of prostatitis. Methods: A total of 40 patients with PZ early PCa and 37 with prostatitis of hypointense T2WI signal in PZ were retrospectively analyzed, which were collected from the General Hospital of Ningxia Medical University from Janurary 2009 to June 2015, who underwent T2WI, DWI, and DCE-MRI examination and all patients were confirmed by pathology...
October 11, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Zhao-Yan Feng, Liang Wang, Xiang-De Min, Shao-Gang Wang, Guo-Ping Wang, Jie Cai
BACKGROUND: Prostate Imaging Reporting and Data System (PI-RADS) is a globally acceptable standardization for multiparametric magnetic resonance imaging (mp-MRI) in prostate cancer (PCa) diagnosis. The American College of Radiology revised the PI-RADS to address the limitations of version 1 in December 2014. This study aimed to determine whether the PI-RADS version 2 (PI-RADS v2) scoring system improves the diagnostic accuracy of mp-MRI of the prostate compared with PI-RADS v1. METHODS: This retrospective study was approved by the institutional review board...
2016: Chinese Medical Journal
P De Visschere, N Lumen, P Ost, K Decaestecker, E Pattyn, G Villeirs
AIM: To determine the added value of dynamic contrast-enhanced imaging (DCE) over T2-weighted imaging (T2-WI) and diffusion-weighted imaging (DWI) for detection of clinically significant prostate cancer (csPC) in patients with elevated prostate-specific antigen (PSA). METHODS AND MATERIALS: Two hundred and forty-five patients with elevated PSA underwent multiparametric (mp) magnetic resonance imaging (MRI) of the prostate before biopsy. mpMRI was performed using a 3 T MRI system without an endorectal coil...
October 7, 2016: Clinical Radiology
Thomas P Frye, Arvin K George, Amichai Kilchevsky, Mahir Maruf, M Minhaj Siddiqui, Michael Kongnyuy, Akhil Muthigi, Hui Han, Howard L Parnes, Maria Merino, Peter L Choyke, Baris Turkbey, Brad Wood, Peter A Pinto
PURPOSE: Active surveillance is an established option for men with low risk prostate cancer. Multiparametric magnetic resonance imaging with magnetic resonance imaging-transrectal ultrasound fusion guided biopsy may better identify patients for active surveillance compared to systematic 12-core biopsy due to improved risk stratification. To our knowledge the performance of multiparametric magnetic resonance imaging in following men on active surveillance with visible lesions is unknown...
September 6, 2016: Journal of Urology
Karen Cecilie Duus Thestrup, Vibeke Logager, Ingerd Baslev, Jakob M Møller, Rasmus Hvass Hansen, Henrik S Thomsen
BACKGROUND: Since multiparametric magnetic resonance imaging (mp-MRI) of the prostate exceeds 30 min, minimizing the evaluation time of significant (Gleason scores > 6) prostate cancer (PCa) would be beneficial. A reduced protocol might be sufficient for the diagnosis. PURPOSE: To study whether a short unenhanced biparametric MRI (bp-MRI) matches mp-MRI in detecting significant PCa. MATERIAL AND METHODS: A total of 204 men (median age, 65 years; mean ± SD, 64...
August 2016: Acta Radiologica Open
Yuke Chen, Wei Yu, Yu Fan, Liqun Zhou, Yang Yang, Huihui Wang, Yuan Jiang, Xiaoying Wang, Shiliang Wu, Jie Jin
PURPOSE: To improve the performation of a nomogram for predicting side-specific extracapsular extension (SS-ECE). RESULTS: One hundred and ninety-six patients (55.5%) had ECE on final pathology. Bilateral and unilateral ECE rate was 13.9% (49/353) and 41.6% (147/353), respectively. The mean age was 65.9 years and the mean serum prostate specific antigen (PSA) was 15.0 ng/ml. Based on multivariate logistic regression analysis, clinical stage (cStage), PSA, Gleason sum, percentage of positive cores, and ECE risk score were significant predictors of ECE...
August 23, 2016: Oncotarget
Thais Caldara Mussi, Rodrigo Gobbo Garcia, Marcos Roberto Gomes Queiroz, Gustavo Caserta Lemos, Ronaldo Hueb Baroni
OBJECTIVE: To evaluate the diagnostic efficacy of transrectal ultrasonography (US) bi¬opsy with imaging fusion using multiparametric (mp) magnetic resonance imaging (MRI) in patients with suspicion of prostate cancer (PCa), with an emphasis on clini¬cally significant tumors according to histological criteria. MATERIALS AND METHODS: A total of 189 consecutive US/MRI fusion biopsies were per¬formed obtaining systematic and guided samples of suspicious areas on mpMRI using a 3 Tesla magnet without endorectal coil...
September 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Pietro Pepe, Antonio Garufi, Giandomenico Priolo, Michele Pennisi
INTRODUCTION: To evaluate the detection rate for clinically significant prostate cancer (PCa) of transperineal (TP) versus transrectal (TR) multiparametric (mp) magnetic resonance imaging (MRI)/transrectal ultrasound-guided (TRUS) fusion targeted biopsy. PATIENTS AND METHODS: From January 2015 to January 2016, a total of 200 men (median age, 61 years) with negative digital rectal examination findings underwent repeat saturation TP prostate biopsy (SPBx; median 30 cores) for increasing or persistent elevated prostate-specific antigen values...
July 21, 2016: Clinical Genitourinary Cancer
Radka Stoyanova, Alan Pollack, Mandeep Takhar, Charles Lynne, Nestor Parra, Lucia L C Lam, Mohammed Alshalalfa, Christine Buerki, Rosa Castillo, Merce Jorda, Hussam Al-Deen Ashab, Oleksandr N Kryvenko, Sanoj Punnen, Dipen J Parekh, Matthew C Abramowitz, Robert J Gillies, Elai Davicioni, Nicholas Erho, Adrian Ishkanian
Standard clinicopathological variables are inadequate for optimal management of prostate cancer patients. While genomic classifiers have improved patient risk classification, the multifocality and heterogeneity of prostate cancer can confound pre-treatment assessment. The objective was to investigate the association of multiparametric (mp)MRI quantitative features with prostate cancer risk gene expression profiles in mpMRI-guided biopsies tissues.Global gene expression profiles were generated from 17 mpMRI-directed diagnostic prostate biopsies using an Affimetrix platform...
July 11, 2016: Oncotarget
Harsh K Agarwal, Francesca V Mertan, Sandeep Sankineni, Marcelino Bernardo, Julien Senegas, Jochen Keupp, Dagane Daar, Maria Merino, Bradford J Wood, Peter A Pinto, Peter L Choyke, Baris Turkbey
PURPOSE: To retrospectively determine the optimal b-value(s) of diffusion-weighted imaging (DWI) associated with intermediate-high risk cancer in the peripheral zone (PZ) of the prostate. MATERIALS AND METHODS: Forty-two consecutive patients underwent multi b-value (16 evenly spaced b-values between 0 and 2000 s/mm(2) ) DWI along with multi-parametric MRI (MP-MRI) of the prostate at 3 Tesla followed by trans-rectal ultrasound/MRI fusion guided targeted biopsy of suspicious lesions detected at MP-MRI...
July 7, 2016: Journal of Magnetic Resonance Imaging: JMRI
Richard Ho, Mohummad M Siddiqui, Arvin K George, Thomas Frye, Amichai Kilchevsky, Michele Fascelli, Nabeel A Shakir, Raju Chelluri, Steven F Abboud, Annerleim Walton-Diaz, Sandeep Sankineni, Maria J Merino, Baris Turkbey, Peter L Choyke, Bradford J Wood, Peter A Pinto
OBJECTIVES: To evaluate the utility of preoperative multiparametric magnetic resonance imaging (MP-MRI) in predicting biochemical recurrence (BCR) following radical prostatectomy (RP). MATERIALS/METHODS: From March 2007 to January 2015, 421 consecutive patients with prostate cancer (PCa) underwent preoperative MP-MRI and RP. BCR-free survival rates were estimated using the Kaplan-Meier method. Cox proportional hazards models were used to identify clinical and imaging variables predictive of BCR...
2016: PloS One
Ali-Reza Sharif-Afshar, Christopher Nguyen, Tom S Feng, Lucas Payor, Zhaoyang Fan, Rola Saouaf, Debiao Li, Hyung L Kim
OBJECTIVES: High-resolution prostate imaging may allow for detection of subtle changes in tumor size, decrease the reliance on biopsies, and help define tumor boundaries during ablation. This pilot clinical trial evaluates a novel high-resolution prostate MRI for detection of small, biopsy-proven prostate tumors. METHODS: Our team developed a software that can be loaded on any modern MRI to generate high resolution diffusion-weighted imaging sequences (HR-DWI), which were compared to standard diffusion-weighted imaging sequence (S-DWI) in a prospective pilot trial in active surveillance patients...
May 2016: EBioMedicine
Ana Fernandez Ots, Joseph Bucci, Yaw Sinn Chin, David Malouf, Andrew Howie, Komiti Ese Enari
BACKGROUND: The objective of focal brachytherapy (BT) is to provide effective prostate cancer control for low-risk disease but with reduced genitourinary, gastrointestinal and sexual side effects in a cost-effective way. OBJECTIVE: The aim of this study is to describe a phase II study examining technical and dosimetric feasibility and toxicity, quality of life changes, and local control with post-treatment biopsy outcomes in men with early stage low volume prostate cancer treated with focal iodine-125 seed BT...
June 13, 2016: JMIR Research Protocols
Brandon J Manley, John A Brockman, Valary T Raup, Kathryn J Fowler, Gerald L Andriole
INTRODUCTION: The use of multi-parametric (MP) MRI to diagnose prostate cancer has been the subject of intense research, with many studies showing positive results. The purpose of our study is to better understand the accessibility, role, and perceived accuracy of MP-MRI in practice by surveying practicing urologists. MATERIALS AND METHODS: Surveys were sent to 7,400 practicing American Urological Association member physicians with a current email address. The survey asked demographic information and addressed access, accuracy, cost, and role of prostate MRI in clinical practice...
May 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
R Faletti, G Battisti, A Discalzi, M L Grognardi, S Martinello, M Oderda, P Gontero, L Bergamasco, M C Cassinis, P Fonio
PURPOSE: To relate the multiparametric magnetic resonance imaging (mp-MRI) of patients with suspect peripheral prostate cancer (PCa) to the results of the subsequent biopsy: in particular to explore whether DWI and ADC can predict the biopsy outcome and to investigate the relation between ADC and Gleason score (GS). MATERIALS AND METHODS: 175 consecutive patients who underwent 1.5 T mp-MRI followed by prostate biopsy were retrospectively analyzed by two independent radiologists...
May 2016: Abdominal Radiology
Rachel Davis, Amirali Salmasi, Christopher Koprowski, Sinae Kim, Young Suk Kwon, Izak Faiena, Neal Patel, Sammy E Elsamra, Isaac Yi Kim
INTRODUCTION: The presence of extracapsular extension (ECE) in prostate cancer (PCa) can influence a surgeon's decision to perform a nerve-sparing approach during radical prostatectomy (RP). Preoperatively, multiparametric MRI (mp-MRI) is often used to stage PCa. More recently, the use of mp-MRI has gained wide acceptance in fusion biopsy of the prostate. In this framework, the reported accuracy of mp-MRI has been highly variable, with data often originating from large referral centers with experienced radiologists...
April 22, 2016: Clinical Genitourinary Cancer
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